Hub : Genes

Gdf11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Gdf11	0.11	0.08	7.5e-08	0.07	0.06	0.06	0.06	6.3e-08	8.9e-07	6.3e-07	1.3e-07
2	pVTA	gene expression	Gdf11	0.11	0.06	3.1e-06	0.06	0.06	0.07	0.07	8.2e-06	5.7e-06	4.0e-06	3.6e-06
3	NAcc	gene expression	Gdf11	0.08	0.04	1.6e-09	0.05	0.06	0.06	0.06	4.5e-08	1.6e-09	3.4e-09	5.0e-09
4	Brain	gene expression	Gdf11	0.07	0.05	1.1e-06	0.06	0.07	0.06	0.06	1.1e-06	7.9e-07	1.1e-06	1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.7	3.2	4.9	0.9	-1.8	-2.0	-2.2
Area under the delay curve	0.1	0.1	0.4	0.1	-0.6	-0.4	-0.0
BMI with tail	4.8	16.8	27.8	5.3	-4.6	-3.5	2.4
BMI without tail	0.7	3.9	6.2	2.5	-2.2	-1.6	1.3
Body weight	0.6	2.8	3.7	1.9	-1.8	-1.1	1.7
Weight adjusted by age	0.0	0.1	0.2	-0.4	0.4	0.4	0.2
Bone surface	2.9	5.6	12.8	0.8	-1.7	-2.5	-3.6
Bone volume	3.1	6.3	12.1	1.1	-2.1	-2.7	-3.5
Breakpoint value in progressive ratio session	0.6	1.0	1.9	-1.1	1.4	1.0	-0.2
Number of licking bursts	0.6	1.8	2.8	1.5	-1.3	-0.6	1.7
Context. condit. distance diff. score	0.1	0.2	0.3	0.6	-0.4	-0.3	0.3
Locomotion velocity, session 1	1.3	1.5	2.3	0.5	-1.3	-1.5	-1.2
Locomotion distance, session 1	1.0	1.3	3.2	0.1	-0.7	-1.2	-1.8
Locomotion velocity, session 2	1.3	1.6	5.3	-0.6	0.0	-0.7	-2.3
Locomotion distance, session 2	1.4	2.0	5.7	-1.5	0.3	-0.2	-2.4
Locomotion velocity, session 3	3.0	3.5	6.2	-2.5	2.1	1.6	-0.9
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.3	0.4	0.2
Stereotopy head waving bouts, day 3	3.1	3.7	6.1	-2.5	2.0	1.4	-1.6
Stereotopy head waving duration, day 3	2.2	2.7	3.7	-1.9	1.9	1.2	-1.4
Locomotion velocity, session 7	0.1	0.1	0.4	-0.0	-0.0	-0.3	-0.6
Locomotion distance, session 7	0.2	0.3	0.9	0.1	0.3	0.5	0.9
Stereotopy head waving bouts, day 7	0.7	0.8	2.5	-0.7	-0.1	-0.4	-1.6
Stereotopy head waving duration, day 7	0.9	1.1	3.4	-0.6	-0.3	-0.8	-1.8
Locomotion velocity, session 8	1.2	1.5	4.6	-0.8	-0.3	-0.8	-2.1
Locomotion distance, session 8	0.2	0.2	0.6	-0.6	0.1	-0.0	-0.8
Degree of sensitization distance	0.4	0.4	0.8	0.9	-0.7	-0.6	0.2
Degree of sensitization stereotypy	0.6	0.7	1.1	0.4	-1.0	-1.0	-0.8
Conditioned locomotion	0.8	0.9	3.1	0.4	-0.1	0.5	1.8
Cocaine response after cond. corrected	0.9	1.3	3.4	1.2	-0.6	0.0	1.8
Cocaine response after cond. not corrected	1.0	1.4	4.1	1.2	-0.4	0.2	2.0
Cocaine response before conditioning	0.3	0.3	0.5	-0.7	0.7	0.4	-0.5
Saline control response	0.3	0.4	1.2	0.5	-0.4	0.0	1.1
Bone: connectivity density	0.9	1.5	2.5	0.6	-1.1	-1.4	-1.6
Bone: cortical apparent density	0.7	1.1	2.2	1.5	-1.1	-0.9	0.3
Bone: cortical area	1.8	3.0	4.0	1.7	-1.8	-2.0	-1.3
Bone: cortical porosity	0.3	0.3	0.5	0.5	-0.3	-0.6	-0.7
Bone: cortical porosity	0.8	0.9	1.2	0.9	-0.7	-1.1	-1.1
Bone: cortical thickness	1.8	2.9	4.5	2.1	-1.9	-1.9	-0.5
Bone: cortical thickness	0.4	0.5	0.9	0.8	-0.5	-0.1	1.0
Bone: cortical tissue density	0.5	0.8	1.6	1.3	-1.0	-0.8	0.3
Condit. Reinf. active minus inactive responses	1.1	1.3	1.9	-1.4	1.3	0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	-0.6	1.0	0.8	0.2
Condit. Reinf. active responses	1.3	1.7	2.8	-1.5	1.1	0.6	-1.7
Condit. Reinf. inactive responses	0.8	1.0	3.1	-1.0	0.2	-0.2	-1.8
Incentive salience index mean	0.6	0.8	1.8	-1.0	0.5	0.1	-1.4
Condit. Reinf. lever presses	0.9	1.3	3.3	-0.2	-0.8	-1.1	-1.8
Condit. Reinf. active minus inactive responses	2.2	3.4	5.2	-2.0	2.3	2.0	0.2
Condit. Reinf. active-inactive response ratio	1.7	2.7	3.8	-1.4	1.8	2.0	1.3
Condit. Reinf. active responses	1.3	1.8	2.9	-1.6	1.7	1.3	-0.6
Condit. Reinf. inactive responses	0.2	0.3	1.1	-0.4	0.3	-0.1	-1.0
Condit. Reinf. lever presses	2.2	3.2	4.5	-2.1	2.1	1.9	-0.1
Condit. Reinf. lever reinforcers received	1.2	1.7	2.8	-1.5	1.7	1.4	-0.2
Conditioned reinforcement - actives	0.0	0.1	0.3	0.2	0.6	0.2	-0.1
Conditioned reinforcement - inactives	0.2	0.5	0.8	0.6	0.7	0.6	0.9
Conditioned locomotion	1.3	1.9	3.4	-1.2	1.8	0.9	-1.4
Patch foraging indifference point 0 sec	1.6	4.4	8.1	2.8	-2.3	-2.1	0.4
Patch foraging indifference point AUC	0.3	0.7	1.4	-1.2	0.9	0.9	-0.1
Delay disc. indifference point, 0s delay	3.7	4.1	6.6	1.7	-2.6	-2.4	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	0.1	-0.0	-0.3
Delay disc. indifference point, 2s delay	0.8	0.9	1.6	0.7	-1.3	-1.1	-0.4
Delay disc. indifference point, 24s delay	0.2	0.3	0.7	0.4	-0.8	-0.6	0.2
Delay disc. indifference point, 4s delay	0.4	0.5	1.2	-0.2	-0.5	-0.6	-1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.6	0.1	-0.2	0.2	0.8
Indifference point function ln k	0.0	0.1	0.2	0.5	0.1	-0.0	0.2
Indifference point function log k	0.0	0.1	0.2	0.5	0.1	-0.0	0.2
Patch foraging total patch changes 0 sec	1.3	3.8	7.1	2.7	-2.1	-1.9	0.4
Patch foraging total patch changes 12 sec	0.9	1.2	2.0	1.4	-1.1	-0.7	1.1
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	0.1	-0.4	-0.3	-0.1
Patch foraging total patch changes 24 sec	0.2	0.7	1.2	0.9	-1.1	-1.0	-0.1
Patch foraging total patch changes 6 sec	1.2	2.1	3.8	1.9	-1.5	-1.5	0.2
Patch foraging time to switch 0 sec	0.3	1.1	1.7	0.8	-1.3	-1.2	-0.7
Patch foraging water rate 0 sec	0.2	0.6	1.9	0.6	0.1	0.4	1.4
Patch foraging water rate 12 sec	0.2	0.7	2.1	0.8	0.1	0.3	1.5
Patch foraging water rate 18 sec	1.4	3.1	5.2	-0.6	1.7	2.0	2.3
Patch foraging water rate 24 sec	2.2	3.1	9.9	0.5	0.6	1.3	3.1
Patch foraging water rate 6 sec	2.0	2.9	4.4	-1.1	2.1	2.1	1.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	1.5	-1.0	0.9	0.4	-1.2
Distance traveled before self-admin	0.5	1.1	1.8	-1.3	1.2	0.9	-0.6
Distance traveled after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.0
Extensor digitorum longus weight	2.6	10.5	17.4	4.2	-3.2	-1.9	3.2
Bone: elastic displacement	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1
Bone: elastic work	1.1	1.4	2.1	1.3	-1.4	-1.3	-0.3
Bone: endosteal estimation	0.5	1.3	1.8	1.4	-1.2	-1.3	-0.5
Bone: endosteal perimeter	0.3	0.7	2.4	-0.3	0.0	-0.4	-1.5
Epididymis fat weight	0.2	1.1	1.4	-0.8	1.1	1.2	1.0
Delta time in closed arm before/after self-admin	1.9	1.7	5.2	0.6	0.6	1.0	2.3
Delta time in open arm before/after self-admin	0.6	0.7	1.3	0.7	-1.2	-0.7	0.6
Diff in mean of infusions in LGA sessions	1.0	1.8	2.8	-1.6	1.7	1.3	-0.5
Delay discount exponential model param	0.1	0.1	0.2	0.0	0.5	0.3	0.0
Extinction: sum of active levers before priming	1.5	2.2	3.2	-1.6	1.8	1.7	0.4
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.3	0.2	0.0	-0.5
Bone: final force	3.6	5.9	8.3	2.7	-2.9	-2.7	-0.8
Bone: final moment	3.6	5.8	8.2	2.6	-2.9	-2.7	-0.8
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.6	-0.7	-0.5	0.2
Glucose	0.9	1.4	2.1	1.4	-1.5	-1.0	0.9
Heart weight	0.5	0.8	1.2	-0.8	1.1	1.0	0.4
Delay discount hyperbolic model param	0.3	0.4	0.8	-0.4	0.9	0.7	0.2
Intermittent access intake day 1-15 change	0.3	1.7	3.7	-0.9	1.9	1.4	0.4
Intermittent access intake escalation	0.3	1.6	3.5	-0.8	1.9	1.4	0.5
Intermittent access intake escalation 2	0.7	1.2	2.5	-1.0	1.6	1.2	0.2
Intermitt. access day 1 inactive lever presses	0.2	2.4	3.3	-1.2	1.8	1.8	1.2
Intermitt. access day 15 inactive lever presses	0.2	1.2	1.9	-1.2	1.4	1.1	0.0
Intermitt. access escalation Index	0.2	0.8	1.1	0.6	-0.8	-1.0	-1.0
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.5	-0.0	-0.1	0.2
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.2	0.6	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	0.2	0.4	-0.1	-0.7
Intermittent access total infusions	0.1	0.1	0.3	0.6	0.1	-0.2	-0.2
Intermittent access day 1 locomotion	0.1	0.3	0.5	-0.1	0.5	0.5	0.7
Intermittent access day 15 total locomotion	0.3	1.1	2.6	-0.5	1.6	1.2	0.3
Intermittent access total locomotion	0.3	0.4	0.8	-0.4	0.9	0.7	0.2
Intermittent access standard deviation	0.2	0.8	1.8	-0.6	1.3	0.5	-1.0
Left kidney weight	0.0	0.1	0.2	-0.2	0.1	0.2	0.4
Right kidney weight	0.1	0.7	1.3	-1.1	0.8	0.9	0.3
Cocaine induced anxiety	0.4	1.0	3.1	-0.9	0.3	-0.1	-1.8
Post-drug Anxiety	1.1	1.2	4.0	-0.2	-0.3	-0.8	-2.0
Baseline Anxiety	0.0	0.0	0.0	0.2	-0.1	-0.1	0.0
Tail length	1.8	9.4	16.0	-4.0	3.4	3.0	-1.0
Length with tail	1.3	5.6	8.5	-2.9	2.7	2.5	-0.1
Length without tail	0.1	0.3	0.8	0.6	-0.3	-0.1	0.9
Times rat made contact with spout	0.5	0.6	1.2	0.9	-0.6	-0.3	1.1
Lifetime Intake	0.4	0.5	1.5	1.2	-0.2	-0.6	-0.2
Liver weight, left	0.2	0.4	0.5	0.7	-0.7	-0.5	0.5
Liver weight, right	0.2	0.3	0.5	-0.7	0.4	0.6	0.4
Locomotor activity	1.4	2.3	4.0	-2.0	1.3	0.7	-1.7
Locomotor testing distance	0.5	1.1	1.9	-1.3	0.9	0.4	-1.4
Locomotor testing rearing	0.0	0.1	0.1	-0.3	0.3	0.3	0.4
Locomotion in novel chamber	0.1	0.1	0.3	0.5	0.0	-0.2	-0.0
Locomotion in novel chamber post-restriction	1.1	3.3	5.7	-2.4	2.0	1.7	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.5	1.7	0.5	-0.4	0.0	1.3
Change in fecal boli incidents, locomotor task	0.7	0.7	2.5	-0.3	-0.2	-0.6	-1.6
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.2	1.0	-1.4	-1.5	-0.9
Bouts of movement, locomotor time 1	0.5	0.6	0.9	-0.9	1.0	0.8	-0.1
Total resting periods, locomotor time 1	0.9	1.0	1.7	-1.3	1.2	1.0	-0.4
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.7	0.2	0.0	-0.8
Distance moved, locomotor task time 1	0.6	1.7	2.6	1.3	-1.4	-1.6	-0.9
Vertical activity count, locomotor time 1	0.1	0.7	1.7	1.3	-0.6	-0.6	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.0	1.0	-0.5	-0.2	1.0
Bouts of movement, locomotor time 2	0.2	0.5	1.5	-0.1	-0.3	-0.7	-1.2
Total resting periods, locomotor time 2	0.2	0.7	2.0	0.0	-0.4	-0.8	-1.4
Rest time, locomotor task time 2	0.2	0.4	0.9	-0.0	-0.5	-0.6	-0.9
Distance moved, locomotor task time 2	0.2	0.3	0.6	-0.1	0.5	0.6	0.8
Vertical activity count, locomotor time 2	0.3	0.8	2.5	0.8	-0.1	0.2	1.6
Light reinforcement 1	0.8	3.8	5.5	-2.3	2.3	1.5	-1.5
Light reinforcement 2	0.4	0.9	1.4	-1.1	1.2	0.8	-0.6
Bone: marrow area	0.5	1.2	1.6	1.3	-1.2	-1.2	-0.5
Bone: maximum diameter	0.5	1.0	3.7	-0.2	-0.1	-0.6	-1.9
Bone: maximum force	2.8	5.5	8.0	2.7	-2.8	-2.6	-0.5
Bone: maximum moment	2.9	5.5	7.9	2.6	-2.8	-2.6	-0.5
Mean time between licks in bursts	0.1	0.9	1.6	-1.0	1.3	1.0	-0.3
Mean num. licks in bursts	0.1	0.4	0.6	-0.8	0.7	0.3	-0.7
Cd content in liver	0.2	0.2	0.4	-0.4	0.6	0.4	-0.4
Co content in liver	2.3	2.7	4.0	-1.9	2.0	1.8	-0.1
Cu content in liver	1.0	1.2	1.7	1.1	-0.9	-1.3	-1.0
Fe content in liver	0.1	0.1	0.3	0.4	0.0	0.1	0.5
K content in liver	0.5	0.5	1.5	-0.6	0.3	-0.1	-1.2
Mg content in liver	0.5	0.6	1.0	-1.0	0.6	0.3	-1.0
Mn content in liver	1.9	2.1	7.1	-0.6	-0.2	-1.0	-2.7
Na content in liver	0.4	0.4	0.7	0.4	-0.7	-0.9	-0.6
Rb content in liver	1.2	1.4	1.9	0.9	-1.0	-1.4	-1.3
Se content in liver	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Sr content in liver	0.6	0.5	0.9	-0.4	1.0	0.9	0.4
Zn content in liver	4.3	5.0	7.2	-2.2	2.7	2.7	0.9
Bone: minimum diameter	0.7	1.3	1.6	1.0	-1.1	-1.3	-1.1
Time in familiar zone, hab. session 1	3.4	3.7	6.1	-2.5	2.2	2.0	-0.2
Time in novel zone, hab. session 1	3.7	4.2	5.6	2.3	-2.3	-2.4	-0.6
Total zone transitions, hab. session 1	0.7	0.9	2.7	-0.3	-0.5	-0.8	-1.7
Total locomotion distance, hab. session 1	1.5	2.2	7.2	-0.9	-0.2	-0.8	-2.7
Locomotion velocity, hab. session 1	1.2	1.6	5.2	-1.1	0.2	-0.4	-2.3
Time in familiar zone, hab. session 2	4.6	5.2	7.6	-2.6	2.7	2.5	0.1
Time in novel zone, hab. session 2	5.4	5.9	8.3	2.8	-2.9	-2.7	-0.3
Total zone transitions, hab. session 2	2.3	3.0	4.6	1.3	-1.9	-2.1	-1.6
Total locomotion distance, hab. session 2	0.5	0.7	2.0	-0.3	-0.4	-0.7	-1.4
Locomotion velocity, hab. session 2	0.8	1.1	3.0	-0.3	-0.6	-1.0	-1.7
Novel to familiar place preference ratio	3.1	4.1	5.8	2.1	-2.4	-2.4	-0.7
Novelty place preference	2.3	3.0	4.2	1.8	-2.0	-2.0	-0.8
Time in novel zone, NPP test	2.7	3.3	4.5	2.0	-2.1	-2.1	-0.6
Total zone transitions, NPP test	0.9	1.4	2.2	0.9	-1.5	-1.4	-0.7
Total locomotion distance, NPP test	0.8	1.1	1.6	0.5	-1.1	-1.2	-1.1
Locomotion velocity, NPP test	0.5	0.8	1.4	0.1	-0.8	-1.0	-1.2
Intraocular pressure	1.1	1.7	2.5	-1.0	1.2	1.6	1.4
Delta distance traveled before/after self-admin	0.4	0.4	0.7	0.7	-0.8	-0.5	0.5
Delta ambulatory time before/after self-admin	0.5	0.8	1.5	0.9	-1.2	-1.0	-0.1
Parametrial fat weight	0.3	0.8	1.2	1.1	-1.1	-1.0	0.0
Pavlov. Cond. lever latency	0.8	1.0	2.2	-0.2	0.8	1.1	1.5
Pavlov. Cond. magazine entry latency	0.9	1.1	1.8	-1.4	1.2	1.0	-0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.6	-0.4	-0.3	-0.0
Pavlov. Cond. index score	0.2	0.3	0.9	-0.5	0.1	-0.1	-1.0
Pavlov. Cond. latency score	0.4	0.5	1.8	-0.4	-0.1	-0.4	-1.3
Pavlov. Cond. lever contacts	0.8	1.0	1.6	0.4	-1.0	-1.1	-1.3
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	0.9	-0.8	-0.8	0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	-0.4	0.9	0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.9	-0.6	0.2	0.0	-0.9
Pavlov. Cond. response bias	0.3	0.3	0.6	-0.8	0.6	0.5	-0.3
Pavlov. Cond. lever latency	0.9	1.3	2.4	1.5	-1.2	-1.1	0.6
Pavlov. Cond. magazine entry latency	1.1	1.6	2.8	-1.7	1.3	1.1	-0.8
Pavlov. Cond. change in total contacts	0.4	0.9	1.3	-1.1	1.1	1.0	-0.2
Pavlov. Cond. index score	1.1	1.7	2.8	-1.7	1.5	1.3	-0.5
Pavlov. Cond. latency score	1.0	1.6	2.9	-1.7	1.3	1.1	-0.8
Pavlov. Cond. lever contacts	1.0	1.5	2.4	-1.6	1.3	1.3	-0.3
Pavlov. Cond. magazine entry number	1.2	1.6	2.7	1.6	-1.3	-1.1	0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.0	1.0	-0.5	-0.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.8	2.8	-1.7	1.5	1.2	-0.8
Pavlov. Cond. response bias	1.7	2.4	3.7	-1.9	1.8	1.6	-0.3
Time in closed arm before self-admin	0.5	0.8	1.1	0.6	-0.9	-1.0	-0.9
Time in closed arm after self-admin	0.2	0.2	0.8	0.9	0.1	-0.0	0.4
Time in open arm before self-admin	0.1	0.1	0.2	0.1	0.5	0.3	-0.0
Time in open arm after self-admin	0.9	1.0	1.4	1.1	-1.2	-0.6	1.1
Bone: periosteal estimation	1.5	3.5	4.7	1.9	-2.0	-2.2	-1.3
Bone: periosteal perimeter	0.7	1.3	2.8	0.6	-0.8	-1.2	-1.7
Bone: post-yield work	0.3	0.5	0.8	0.9	-0.8	-0.7	0.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	0.7	-0.3	-0.3	0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	0.7	-0.2	-0.3	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.9	-0.3	1.0	0.5	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.1	0.6	0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.2	0.6	0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.4	0.6	-0.1	-0.6	-0.6
Incentive Sensitization - Responses	0.1	0.4	0.6	-0.8	0.8	0.6	-0.1
Incentive Sensitization - Breakpoint	0.2	0.4	0.7	-0.8	0.8	0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.4	0.5	0.5	0.1
Progressive ratio	0.2	0.7	1.5	1.2	-0.4	-0.3	1.0
Food seeking constrained by brief footshock	1.0	1.3	3.0	-1.7	1.0	1.1	-0.3
Seeking ratio, punishment vs. effort	0.8	1.8	4.2	-2.1	1.1	1.1	-0.7
Retroperitoneal fat weight	0.9	4.2	7.3	2.5	-1.5	-0.7	2.7
Reaction time number correct	0.2	0.7	2.3	0.7	-0.3	0.1	1.5
Reaction time mean minus median	0.1	0.8	1.6	-1.3	0.9	0.7	-0.8
Reaction time mean minus median AUC	0.2	1.3	4.0	-1.0	0.0	-0.4	-2.0
Reaction time num false alarms	0.3	0.5	0.8	0.9	-0.7	-0.4	0.6
Reaction time num false alarms AUC	0.2	0.4	0.7	0.8	-0.5	-0.2	0.9
Reaction time trials correct on left	0.2	0.7	2.3	0.7	-0.3	0.1	1.5
Reaction time trials on left	0.2	0.7	2.0	0.7	-0.3	0.1	1.4
Reaction time mean	0.4	0.9	2.3	-1.0	0.2	-0.1	-1.5
Reaction time mean AUC	0.2	0.6	1.8	-0.6	-0.1	-0.4	-1.3
Median of all reaction times	0.4	0.6	1.9	-0.7	-0.0	-0.3	-1.4
Reaction time omissions	0.2	0.3	0.8	0.3	-0.4	-0.6	-0.9
Reaction time false alarm rate	0.2	0.2	0.4	0.5	-0.6	-0.5	-0.1
Reaction time premature initiation rate	1.5	2.4	3.4	-1.7	1.8	1.7	0.5
Reaction time premature initiations	0.8	2.5	3.2	-1.4	1.7	1.8	1.4
Std. dev. reaction times	0.2	0.5	1.4	-0.8	0.3	0.0	-1.2
Reaction time trials completed	0.2	0.7	2.0	0.7	-0.3	0.1	1.4
Reaction time trials AUC	0.2	0.9	2.8	0.7	-0.3	0.2	1.7
Run reversals in cocaine runway, females	1.2	1.3	2.4	-1.5	0.7	0.4	-1.5
Run reversals in cocaine runway, males	1.0	1.1	1.9	-1.2	0.8	0.5	-1.4
Latency to leave start box in cocaine runway	1.1	1.5	2.2	0.4	-1.3	-1.5	-1.3
Latency to leave start box in cocaine runway, F	2.0	2.6	3.7	0.5	-1.8	-1.9	-1.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	0.3	0.3	0.4
Std. dev. time between licks in bursts	0.4	0.8	2.6	-0.5	0.1	-0.4	-1.6
Total sessions with >9 infusions	0.4	0.5	1.4	1.2	0.0	-0.5	-0.3
Short access day 1 total inactive lever presses	0.4	0.8	1.5	-0.8	1.2	1.0	0.3
Short access day 10 total inactive lever presses	0.3	2.1	2.9	-0.8	1.7	1.7	1.4
Short access day 1 total infusions	0.2	0.4	1.4	1.2	0.2	-0.5	-0.3
Short access day 10 total infusions	0.1	0.1	0.4	0.6	0.1	-0.2	0.0
Short access total infusions	0.5	0.7	2.1	1.5	-0.2	-0.8	-0.3
Short access day 1 locomotion	0.5	0.7	1.8	-0.6	1.4	0.9	-0.2
Short access day 10 total locomotion	1.1	4.5	8.7	-1.8	3.0	2.4	0.6
Short access total locomotion	0.6	0.8	2.1	-0.6	1.4	1.0	0.1
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.3	0.3	0.2	0.6
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.2	-0.0	-0.2
One hour access (shock baseline)	0.1	0.2	0.6	-0.2	0.8	0.4	0.1
Social response proportion	0.4	0.5	1.1	-1.1	0.3	0.1	-0.8
Social responses	4.4	5.8	11.4	-3.4	2.2	1.5	-2.2
Social time	0.5	0.8	1.1	1.0	-0.8	-0.5	1.0
Soleus weight	3.8	11.1	17.6	4.2	-3.9	-2.9	1.8
Bone: stiffness	3.2	5.8	8.4	2.9	-2.8	-2.6	-0.2
Tibialis anterior weight	0.9	3.0	4.6	2.1	-2.0	-1.5	1.0
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.4	-0.7	0.6	0.2	-1.2
Time to tail flick, vehicle, after self-admin	0.7	1.3	1.9	-1.1	1.1	1.4	1.0
Time to tail flick, test, before self-admin	0.6	0.7	2.5	-0.3	-0.1	-0.5	-1.6
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.3	-0.3	-0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.9	1.0	3.4	0.4	-0.4	0.3	1.8
Delta time to tail flick, test, before/after SA	0.7	0.8	1.8	-0.3	0.7	1.0	1.3
Tibia length	0.7	1.9	3.4	-1.8	1.4	1.4	-0.2
Ambulatory time before self-admin	0.1	0.4	0.6	-0.7	0.8	0.6	-0.2
Ambulatory time after self-admin	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.0
Bone: tissue strength	4.0	4.2	7.0	2.6	-2.3	-2.1	0.3
Total heroin consumption	1.1	1.3	2.4	-1.6	1.0	0.7	-1.1
Bone: trabecular number	0.5	1.0	3.0	-0.3	-0.6	-0.8	-1.7
Bone: trabecular spacing	1.8	2.6	5.7	-0.3	1.4	1.7	2.4
Bone: trabecular thickness	4.5	6.3	9.6	1.3	-2.3	-2.9	-3.1
Bone: trabecular tissue density	1.9	3.4	6.3	2.5	-1.7	-1.2	1.7
Water consumed over 24 hours	0.7	1.3	1.9	1.2	-1.3	-1.4	-0.5
Number of responses in last shaping day	2.3	2.9	6.2	-1.5	2.5	1.8	-0.2