Hub : Genes

Gal

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Gal 0.22 0.11 1.8e-06 0.12 0.12 0.07 0.07 1.0e-05 1.1e-05 5.8e-04 6.8e-04
2 PL gene expression Gal 0.04 0.03 1.2e-04 0.01 0.03 0.03 0.03 1.5e-02 1.0e-04 1.7e-04 8.5e-04
3 NAcc gene expression Gal 0.03 0.02 3.8e-05 0.04 0.03 0.03 0.03 3.2e-06 2.7e-05 9.0e-05 8.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.64.57.0-0.52.52.6
Area under the delay curve0.70.81.3-0.21.11.0
BMI with tail2.06.811.2-1.82.43.4
BMI without tail1.02.94.4-2.10.91.9
Body weight1.46.012.4-3.50.32.4
Weight adjusted by age0.30.51.0-1.0-0.60.2
Bone surface3.25.79.3-1.72.23.1
Bone volume2.03.75.8-0.72.12.4
Breakpoint value in progressive ratio session1.01.22.8-1.7-0.10.9
Number of licking bursts0.00.10.2-0.10.40.2
Context. condit. distance diff. score0.30.40.91.00.60.0
Locomotion velocity, session 10.00.00.00.10.20.1
Locomotion distance, session 11.51.92.9-0.31.61.7
Locomotion velocity, session 21.01.23.0-1.7-0.40.6
Locomotion distance, session 20.60.81.4-0.60.91.2
Locomotion velocity, session 31.51.72.70.11.61.5
Locomotion distance, session 30.10.10.2-0.00.40.4
Stereotopy head waving bouts, day 31.11.32.20.31.51.2
Stereotopy head waving duration, day 30.70.91.50.91.20.6
Locomotion velocity, session 70.80.81.5-0.31.01.2
Locomotion distance, session 70.40.40.7-0.90.20.7
Stereotopy head waving bouts, day 71.21.42.60.51.61.1
Stereotopy head waving duration, day 71.21.52.3-0.41.41.5
Locomotion velocity, session 80.80.92.2-1.5-0.20.7
Locomotion distance, session 80.40.50.80.70.90.5
Degree of sensitization distance0.40.50.7-0.70.40.9
Degree of sensitization stereotypy0.60.61.0-0.11.01.0
Conditioned locomotion1.92.23.7-1.4-1.9-0.9
Cocaine response after cond. corrected0.00.10.10.20.30.1
Cocaine response after cond. not corrected0.30.30.60.40.80.5
Cocaine response before conditioning0.10.20.40.10.60.4
Saline control response1.41.94.6-2.1-0.31.0
Bone: connectivity density3.55.59.1-1.52.33.0
Bone: cortical apparent density0.40.50.9-0.7-0.9-0.4
Bone: cortical area0.30.40.7-0.6-0.8-0.5
Bone: cortical porosity0.00.00.00.00.20.2
Bone: cortical porosity0.10.10.2-0.5-0.00.2
Bone: cortical thickness2.43.95.7-2.3-2.4-1.0
Bone: cortical thickness0.80.91.7-1.3-1.0-0.2
Bone: cortical tissue density0.50.61.0-0.9-1.0-0.4
Condit. Reinf. active minus inactive responses0.40.50.70.20.80.8
Condit. Reinf. active-inactive response ratio0.30.30.60.40.80.5
Condit. Reinf. active responses0.10.10.20.40.40.2
Condit. Reinf. inactive responses0.10.10.10.3-0.3-0.4
Incentive salience index mean0.30.30.50.20.70.7
Condit. Reinf. lever presses0.00.00.00.2-0.1-0.1
Condit. Reinf. active minus inactive responses1.31.62.61.21.61.0
Condit. Reinf. active-inactive response ratio1.61.93.92.01.30.3
Condit. Reinf. active responses1.21.72.80.31.71.5
Condit. Reinf. inactive responses1.11.52.2-1.20.81.5
Condit. Reinf. lever presses1.01.42.3-0.51.31.5
Condit. Reinf. lever reinforcers received1.31.92.80.11.71.7
Conditioned reinforcement - actives0.50.81.20.5-1.0-1.1
Conditioned reinforcement - inactives1.21.74.32.10.8-0.5
Conditioned locomotion4.55.913.03.60.1-2.1
Patch foraging indifference point 0 sec0.00.00.00.10.2-0.2
Patch foraging indifference point AUC0.50.71.1-0.8-1.0-0.5
Delay disc. indifference point, 0s delay1.41.53.20.11.81.2
Delay disc. indifference point, 16s delay0.50.51.11.00.7-0.1
Delay disc. indifference point, 2s delay0.50.51.10.51.00.5
Delay disc. indifference point, 24s delay0.30.40.5-0.6-0.7-0.5
Delay disc. indifference point, 4s delay0.40.40.6-0.10.80.8
Delay disc. indifference point, 8s delay0.30.40.6-0.50.60.8
Indifference point function ln k1.22.15.02.20.3-1.0
Indifference point function log k1.22.15.02.20.3-1.0
Patch foraging total patch changes 0 sec0.10.20.3-0.3-0.4-0.6
Patch foraging total patch changes 12 sec1.11.43.7-1.9-0.50.5
Patch foraging total patch changes 18 sec0.20.30.7-0.90.10.3
Patch foraging total patch changes 24 sec0.50.81.6-1.3-0.9-0.3
Patch foraging total patch changes 6 sec0.71.11.9-1.40.51.0
Patch foraging time to switch 0 sec1.93.86.4-1.31.82.5
Patch foraging water rate 0 sec3.06.410.72.2-1.9-3.3
Patch foraging water rate 12 sec4.08.311.63.3-1.6-3.4
Patch foraging water rate 18 sec0.91.42.71.6-0.4-1.2
Patch foraging water rate 24 sec2.83.96.21.6-1.7-2.5
Patch foraging water rate 6 sec2.23.25.31.2-1.7-2.3
Seeking ratio, delayed vs. immediate footshock0.70.91.4-0.11.11.2
Distance traveled before self-admin0.30.40.70.10.80.8
Distance traveled after self-admin0.10.10.1-0.00.30.3
Extensor digitorum longus weight3.112.230.4-5.5-2.21.2
Bone: elastic displacement2.32.64.10.1-2.0-1.9
Bone: elastic work1.31.72.4-1.5-1.6-0.5
Bone: endosteal estimation1.02.13.61.41.90.9
Bone: endosteal perimeter2.24.67.02.42.61.2
Epididymis fat weight2.06.817.04.10.8-1.7
Delta time in closed arm before/after self-admin0.70.71.3-1.1-0.8-0.0
Delta time in open arm before/after self-admin0.40.40.60.40.80.6
Diff in mean of infusions in LGA sessions0.30.30.7-0.8-0.50.0
Delay discount exponential model param0.50.60.80.2-0.9-0.9
Extinction: sum of active levers before priming1.31.42.0-1.30.61.4
Active lever presses in extinction session 60.60.61.4-1.2-0.70.1
Bone: final force0.61.02.0-1.40.21.0
Bone: final moment0.60.92.0-1.40.10.9
Food consumed during 24 hour testing period0.30.50.80.8-0.2-0.9
Glucose2.43.75.71.92.41.3
Heart weight1.21.93.50.41.91.4
Delay discount hyperbolic model param0.60.61.00.1-1.0-1.0
Intermittent access intake day 1-15 change1.12.25.22.30.1-1.2
Intermittent access intake escalation1.02.04.52.1-0.0-1.2
Intermittent access intake escalation 21.31.53.61.90.1-0.9
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.2-0.1
Intermitt. access day 15 inactive lever presses0.61.22.01.41.20.4
Intermitt. access escalation Index1.52.13.61.9-0.4-1.6
Intermittent access day 1 total infusions1.93.15.51.32.31.5
Intermittent access day 15 total infusions2.33.58.42.91.4-0.3
Intermittent access terminal intake (last 3 days)2.43.16.22.51.80.2
Intermittent access total infusions1.82.23.31.81.70.6
Intermittent access day 1 locomotion1.01.22.20.91.50.8
Intermittent access day 15 total locomotion1.93.47.82.81.5-0.2
Intermittent access total locomotion3.84.69.73.12.00.0
Intermittent access standard deviation0.30.61.41.20.6-0.2
Left kidney weight0.52.56.32.50.8-0.7
Right kidney weight0.52.14.92.2-0.0-1.2
Cocaine induced anxiety0.10.10.20.20.50.3
Post-drug Anxiety0.20.30.5-0.70.10.5
Baseline Anxiety0.30.30.7-0.8-0.60.1
Tail length0.83.04.8-2.2-1.9-0.8
Length with tail1.25.312.0-3.5-2.00.1
Length without tail0.92.96.7-2.6-1.40.3
Times rat made contact with spout0.60.71.2-0.50.81.1
Lifetime Intake1.01.21.81.31.30.5
Liver weight, left0.50.81.30.5-0.9-1.1
Liver weight, right0.61.11.61.3-0.6-1.2
Locomotor activity0.71.21.91.4-0.3-1.2
Locomotor testing distance0.71.32.11.5-0.5-1.3
Locomotor testing rearing0.61.22.61.60.90.0
Locomotion in novel chamber2.53.27.62.81.3-0.6
Locomotion in novel chamber post-restriction1.42.25.42.30.7-0.9
Fecal boli incidents, locomotor time 10.00.10.20.40.1-0.1
Change in fecal boli incidents, locomotor task0.10.10.3-0.50.10.4
Time >=10cm from walls, locomotor time 11.81.93.51.11.91.0
Bouts of movement, locomotor time 11.21.31.7-1.3-1.3-0.7
Total resting periods, locomotor time 10.80.91.3-0.9-1.1-0.8
Rest time, locomotor task time 11.31.62.51.6-0.6-1.4
Distance moved, locomotor task time 10.81.32.1-0.21.31.5
Vertical activity count, locomotor time 10.30.71.10.91.00.5
Time >=10cm from walls, locomotor time 20.10.20.40.2-0.4-0.6
Bouts of movement, locomotor time 20.20.30.9-0.9-0.30.1
Total resting periods, locomotor time 20.10.10.4-0.6-0.00.2
Rest time, locomotor task time 21.31.73.21.81.30.1
Distance moved, locomotor task time 20.80.91.4-1.1-1.2-0.4
Vertical activity count, locomotor time 21.52.13.7-0.4-1.9-1.5
Light reinforcement 10.30.71.31.1-0.3-0.9
Light reinforcement 21.21.94.02.0-0.1-1.3
Bone: marrow area1.02.23.71.51.90.9
Bone: maximum diameter0.10.20.40.6-0.0-0.4
Bone: maximum force1.83.25.3-1.41.62.3
Bone: maximum moment1.62.84.5-1.41.42.1
Mean time between licks in bursts0.20.51.2-1.1-0.40.1
Mean num. licks in bursts0.10.10.3-0.10.30.5
Cd content in liver0.70.82.11.50.5-0.4
Co content in liver1.82.13.30.8-1.5-1.8
Cu content in liver0.00.00.00.0-0.2-0.1
Fe content in liver0.00.00.1-0.3-0.20.0
K content in liver0.40.40.7-0.40.60.9
Mg content in liver0.50.50.70.80.80.4
Mn content in liver0.80.92.4-1.6-0.20.6
Na content in liver0.60.61.00.1-0.9-1.0
Rb content in liver1.11.31.71.31.30.8
Se content in liver0.30.30.50.20.70.6
Sr content in liver1.31.22.1-1.5-1.1-0.5
Zn content in liver0.40.50.7-0.8-0.8-0.3
Bone: minimum diameter1.73.05.11.42.31.4
Time in familiar zone, hab. session 10.50.50.70.80.80.4
Time in novel zone, hab. session 10.10.10.2-0.4-0.4-0.3
Total zone transitions, hab. session 10.20.30.5-0.40.50.7
Total locomotion distance, hab. session 10.40.61.21.10.70.1
Locomotion velocity, hab. session 10.20.30.60.80.50.1
Time in familiar zone, hab. session 20.50.60.9-0.8-1.0-0.5
Time in novel zone, hab. session 20.80.91.40.21.21.1
Total zone transitions, hab. session 23.54.57.5-0.92.32.7
Total locomotion distance, hab. session 21.31.72.70.31.61.5
Locomotion velocity, hab. session 21.21.62.80.61.71.3
Novel to familiar place preference ratio0.40.40.7-0.50.60.9
Novelty place preference0.40.40.6-0.20.70.8
Time in novel zone, NPP test0.40.40.7-0.20.80.8
Total zone transitions, NPP test1.01.52.3-0.91.11.5
Total locomotion distance, NPP test0.40.50.90.30.90.7
Locomotion velocity, NPP test0.20.30.60.30.80.5
Intraocular pressure1.01.52.21.0-1.1-1.5
Delta distance traveled before/after self-admin0.10.10.2-0.2-0.4-0.4
Delta ambulatory time before/after self-admin0.20.20.4-0.3-0.6-0.4
Parametrial fat weight1.33.17.32.71.4-0.3
Pavlov. Cond. lever latency0.20.20.30.6-0.3-0.5
Pavlov. Cond. magazine entry latency0.60.81.40.11.21.0
Pavlov. Cond. change in total contacts0.50.50.80.70.90.4
Pavlov. Cond. index score0.10.10.10.30.30.0
Pavlov. Cond. latency score0.10.10.20.10.50.3
Pavlov. Cond. lever contacts0.10.10.1-0.10.40.3
Pavlov. Cond. magazine entry number0.00.00.0-0.2-0.10.1
Pavlov. Cond. intertrial magazine entries0.50.61.00.5-0.8-1.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.30.40.1
Pavlov. Cond. response bias0.00.00.10.20.1-0.2
Pavlov. Cond. lever latency0.00.00.1-0.3-0.20.1
Pavlov. Cond. magazine entry latency2.53.04.8-1.71.12.2
Pavlov. Cond. change in total contacts0.50.91.3-0.31.11.1
Pavlov. Cond. index score0.71.01.6-0.70.91.3
Pavlov. Cond. latency score0.50.71.1-0.60.81.1
Pavlov. Cond. lever contacts0.00.10.10.20.30.1
Pavlov. Cond. magazine entry number2.83.55.32.0-1.1-2.3
Pavlov. Cond. intertrial magazine entries0.50.71.11.0-0.5-1.0
Pavlov. Cond. lever-magazine prob. diff.0.91.11.8-0.90.91.4
Pavlov. Cond. response bias0.71.01.7-0.60.91.3
Time in closed arm before self-admin0.60.71.11.01.00.4
Time in closed arm after self-admin0.00.10.10.2-0.2-0.3
Time in open arm before self-admin0.70.81.3-0.9-1.1-0.5
Time in open arm after self-admin0.30.30.5-0.70.10.6
Bone: periosteal estimation0.10.20.30.50.60.1
Bone: periosteal perimeter0.40.71.20.41.10.8
Bone: post-yield work6.69.716.10.54.03.6
Progressive ratio test 1 active lever presses0.00.10.10.1-0.3-0.3
Progressive ratio test 1 breakpoint0.00.10.10.0-0.3-0.3
Progressive ratio test 1 inactive lever presses0.00.00.00.1-0.1-0.1
Progressive ratio test 2 active lever presses0.70.82.01.40.6-0.2
Progressive ratio test 2 breakpoint0.70.81.91.40.5-0.2
Progressive ratio test 2 inactive lever presses2.43.99.83.11.3-0.6
Incentive Sensitization - Responses0.50.71.1-0.00.91.0
Incentive Sensitization - Breakpoint0.50.60.90.21.00.9
Sum of active levers in priming session hrs 5-63.12.94.30.1-2.1-2.1
Progressive ratio3.04.77.5-1.22.32.7
Food seeking constrained by brief footshock0.10.20.3-0.50.20.4
Seeking ratio, punishment vs. effort1.92.74.51.1-1.6-2.1
Retroperitoneal fat weight3.715.739.46.31.6-2.3
Reaction time number correct0.20.40.7-0.4-0.9-0.6
Reaction time mean minus median0.41.01.6-1.10.41.3
Reaction time mean minus median AUC0.20.40.8-0.9-0.10.6
Reaction time num false alarms0.71.01.5-0.2-1.2-1.2
Reaction time num false alarms AUC0.60.91.4-0.9-1.2-0.7
Reaction time trials correct on left0.20.40.7-0.4-0.9-0.6
Reaction time trials on left0.30.50.9-0.5-0.9-0.6
Reaction time mean0.20.40.60.10.80.8
Reaction time mean AUC0.30.50.80.20.90.8
Median of all reaction times0.40.61.00.41.00.8
Reaction time omissions0.71.02.3-1.5-0.20.7
Reaction time false alarm rate0.30.40.7-0.5-0.8-0.6
Reaction time premature initiation rate1.31.84.6-2.1-0.50.8
Reaction time premature initiations1.32.45.6-2.4-1.20.3
Std. dev. reaction times0.20.40.8-0.60.40.9
Reaction time trials completed0.30.50.9-0.5-0.9-0.6
Reaction time trials AUC0.20.40.7-0.4-0.8-0.5
Run reversals in cocaine runway, females1.11.11.7-0.90.91.3
Run reversals in cocaine runway, males0.60.61.0-0.1-1.0-0.9
Latency to leave start box in cocaine runway1.01.12.00.41.41.1
Latency to leave start box in cocaine runway, F0.80.91.60.21.31.1
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.20.2
Std. dev. time between licks in bursts1.11.62.7-0.9-1.7-1.1
Total sessions with >9 infusions0.20.20.3-0.40.30.6
Short access day 1 total inactive lever presses0.70.92.21.50.4-0.5
Short access day 10 total inactive lever presses0.00.00.00.00.10.2
Short access day 1 total infusions0.30.41.01.00.60.1
Short access day 10 total infusions1.31.72.70.11.61.5
Short access total infusions0.40.50.80.00.90.9
Short access day 1 locomotion0.40.51.11.00.7-0.0
Short access day 10 total locomotion0.40.71.20.81.10.4
Short access total locomotion0.50.60.91.00.90.2
One hour access (0.3 mA shock)2.12.45.82.41.1-0.5
Compulsive drug intake1.82.24.0-2.0-1.5-0.3
One hour access (shock baseline)2.64.010.03.21.2-0.7
Social response proportion0.40.50.9-0.50.50.9
Social responses0.10.10.2-0.5-0.5-0.1
Social time0.10.20.4-0.6-0.10.5
Soleus weight2.16.110.73.3-0.8-2.6
Bone: stiffness1.72.84.5-0.91.72.1
Tibialis anterior weight4.214.128.5-5.3-3.7-0.6
Time to tail flick, vehicle, before self-admin1.41.42.3-0.41.31.5
Time to tail flick, vehicle, after self-admin1.62.13.5-1.21.21.9
Time to tail flick, test, before self-admin1.81.93.40.81.81.3
Time to tail flick, test, after self-admin0.10.10.1-0.2-0.3-0.2
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.90.30.7
Delta time to tail flick, test, before/after SA3.73.86.8-1.1-2.6-1.9
Tibia length0.51.52.4-0.3-1.6-1.4
Ambulatory time before self-admin0.50.71.20.11.11.0
Ambulatory time after self-admin0.81.01.60.91.30.7
Bone: tissue strength0.50.50.70.80.90.4
Total heroin consumption1.92.25.5-2.4-0.70.8
Bone: trabecular number2.44.06.3-0.62.32.5
Bone: trabecular spacing0.81.01.50.2-1.2-1.2
Bone: trabecular thickness1.51.93.40.71.81.4
Bone: trabecular tissue density3.55.28.32.9-0.8-2.6
Water consumed over 24 hours0.70.91.3-1.10.61.1
Number of responses in last shaping day0.10.10.2-0.3-0.5-0.2