Hub : Genes

Gal

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Gal 0.22 0.11 1.8e-06 0.12 0.12 0.07 0.07 1.0e-05 1.1e-05 5.7e-04 6.7e-04
2 PL gene expression Gal 0.04 0.03 1.2e-04 0.01 0.03 0.03 0.03 1.5e-02 1.0e-04 1.7e-04 9.0e-04
3 NAcc gene expression Gal 0.03 0.02 3.8e-05 0.04 0.03 0.03 0.03 3.2e-06 2.7e-05 9.0e-05 8.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.44.57.00.52.5-2.6
Area under the delay curve0.50.81.30.21.1-1.0
BMI with tail1.96.811.21.82.4-3.4
BMI without tail0.62.94.42.10.9-1.9
Body weight1.46.012.43.50.3-2.4
Weight adjusted by age0.20.51.01.0-0.6-0.2
Bone surface2.95.79.31.72.2-3.1
Bone volume1.83.75.80.72.1-2.4
Breakpoint value in progressive ratio session0.71.22.81.7-0.1-0.9
Number of licking bursts0.00.10.20.10.4-0.2
Context. condit. distance diff. score0.30.40.9-1.00.6-0.0
Locomotion velocity, session 10.00.00.0-0.10.2-0.1
Locomotion distance, session 11.41.92.90.31.6-1.7
Locomotion velocity, session 21.01.23.01.7-0.4-0.6
Locomotion distance, session 20.60.81.40.60.9-1.2
Locomotion velocity, session 31.51.72.7-0.11.6-1.5
Locomotion distance, session 30.10.10.20.00.4-0.4
Stereotopy head waving bouts, day 31.11.32.2-0.31.5-1.2
Stereotopy head waving duration, day 30.70.91.5-0.91.2-0.6
Locomotion velocity, session 70.80.81.50.31.0-1.2
Locomotion distance, session 70.30.40.70.90.2-0.7
Stereotopy head waving bouts, day 71.21.42.6-0.51.6-1.1
Stereotopy head waving duration, day 71.21.52.30.41.4-1.5
Locomotion velocity, session 80.70.92.21.5-0.2-0.7
Locomotion distance, session 80.40.50.8-0.70.9-0.5
Degree of sensitization distance0.40.50.70.70.4-0.9
Degree of sensitization stereotypy0.60.61.00.11.0-1.0
Conditioned locomotion1.82.23.71.4-1.90.9
Cocaine response after cond. corrected0.00.10.1-0.20.3-0.1
Cocaine response after cond. not corrected0.20.30.6-0.40.8-0.5
Cocaine response before conditioning0.10.20.4-0.10.6-0.4
Saline control response1.41.94.62.1-0.3-1.0
Bone: connectivity density3.55.59.11.52.3-3.0
Bone: cortical apparent density0.30.50.90.7-0.90.4
Bone: cortical area0.30.40.70.6-0.80.5
Bone: cortical porosity0.00.00.0-0.00.2-0.2
Bone: cortical porosity0.10.10.20.5-0.0-0.2
Bone: cortical thickness2.33.95.72.3-2.41.0
Bone: cortical thickness0.70.91.71.3-1.00.2
Bone: cortical tissue density0.40.61.00.9-1.00.4
Condit. Reinf. active minus inactive responses0.40.50.7-0.20.8-0.8
Condit. Reinf. active-inactive response ratio0.30.30.6-0.40.8-0.5
Condit. Reinf. active responses0.10.10.2-0.40.4-0.2
Condit. Reinf. inactive responses0.10.10.1-0.3-0.30.4
Incentive salience index mean0.30.30.5-0.20.7-0.7
Condit. Reinf. lever presses0.00.00.0-0.2-0.10.1
Condit. Reinf. active minus inactive responses1.11.62.6-1.21.6-1.0
Condit. Reinf. active-inactive response ratio1.21.93.9-2.01.3-0.3
Condit. Reinf. active responses1.21.72.8-0.31.7-1.5
Condit. Reinf. inactive responses1.01.52.21.20.8-1.5
Condit. Reinf. lever presses1.01.42.30.51.3-1.5
Condit. Reinf. lever reinforcers received1.31.92.8-0.11.7-1.7
Conditioned reinforcement - actives0.20.81.2-0.5-1.01.1
Conditioned reinforcement - inactives0.61.74.3-2.10.80.5
Conditioned locomotion4.05.913.0-3.60.12.1
Patch foraging indifference point 0 sec0.00.00.0-0.10.20.2
Patch foraging indifference point AUC0.30.71.10.8-1.00.5
Delay disc. indifference point, 0s delay1.41.53.2-0.11.8-1.2
Delay disc. indifference point, 16s delay0.40.51.1-1.00.70.1
Delay disc. indifference point, 2s delay0.50.51.1-0.51.0-0.5
Delay disc. indifference point, 24s delay0.20.40.50.6-0.70.5
Delay disc. indifference point, 4s delay0.40.40.60.10.8-0.8
Delay disc. indifference point, 8s delay0.20.40.60.50.6-0.8
Indifference point function ln k0.72.15.0-2.20.31.0
Indifference point function log k0.72.15.0-2.20.31.0
Patch foraging total patch changes 0 sec0.10.20.30.3-0.40.6
Patch foraging total patch changes 12 sec1.01.43.71.9-0.5-0.5
Patch foraging total patch changes 18 sec0.10.30.70.90.1-0.3
Patch foraging total patch changes 24 sec0.20.81.61.3-0.90.3
Patch foraging total patch changes 6 sec0.61.11.91.40.5-1.0
Patch foraging time to switch 0 sec1.03.86.41.31.8-2.5
Patch foraging water rate 0 sec1.76.410.7-2.2-1.93.3
Patch foraging water rate 12 sec2.18.311.6-3.3-1.63.4
Patch foraging water rate 18 sec0.61.42.7-1.6-0.41.2
Patch foraging water rate 24 sec2.73.96.2-1.6-1.72.5
Patch foraging water rate 6 sec2.13.25.3-1.2-1.72.3
Seeking ratio, delayed vs. immediate footshock0.60.91.40.11.1-1.2
Distance traveled before self-admin0.20.40.7-0.10.8-0.8
Distance traveled after self-admin0.00.10.10.00.3-0.3
Extensor digitorum longus weight3.012.230.45.5-2.2-1.2
Bone: elastic displacement2.12.64.1-0.1-2.01.9
Bone: elastic work1.31.72.41.5-1.60.5
Bone: endosteal estimation0.92.13.6-1.41.9-0.9
Bone: endosteal perimeter1.94.67.0-2.42.6-1.2
Epididymis fat weight1.36.817.0-4.10.81.7
Delta time in closed arm before/after self-admin0.70.71.31.1-0.80.0
Delta time in open arm before/after self-admin0.30.40.6-0.40.8-0.6
Diff in mean of infusions in LGA sessions0.20.30.70.8-0.5-0.0
Delay discount exponential model param0.40.60.8-0.2-0.90.9
Extinction: sum of active levers before priming0.91.42.01.30.6-1.4
Active lever presses in extinction session 60.60.61.41.2-0.7-0.1
Bone: final force0.61.02.01.40.2-1.0
Bone: final moment0.60.92.01.40.1-0.9
Food consumed during 24 hour testing period0.20.50.8-0.8-0.20.9
Glucose2.43.75.7-1.92.4-1.3
Heart weight1.21.93.5-0.41.9-1.4
Delay discount hyperbolic model param0.50.61.0-0.1-1.01.0
Intermittent access intake day 1-15 change0.42.25.2-2.30.11.2
Intermittent access intake escalation0.42.04.5-2.1-0.01.2
Intermittent access intake escalation 20.91.53.6-1.90.10.9
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1-0.20.1
Intermitt. access day 15 inactive lever presses0.21.22.0-1.41.2-0.4
Intermitt. access escalation Index0.72.13.6-1.9-0.41.6
Intermittent access day 1 total infusions1.03.15.5-1.32.3-1.5
Intermittent access day 15 total infusions1.43.58.4-2.91.40.3
Intermittent access terminal intake (last 3 days)1.83.16.2-2.51.8-0.2
Intermittent access total infusions1.82.23.3-1.81.7-0.6
Intermittent access day 1 locomotion0.71.22.2-0.91.5-0.8
Intermittent access day 15 total locomotion0.93.47.8-2.81.50.2
Intermittent access total locomotion3.84.69.7-3.12.0-0.0
Intermittent access standard deviation0.10.61.4-1.20.60.2
Left kidney weight0.32.56.3-2.50.80.7
Right kidney weight0.32.14.9-2.2-0.01.2
Cocaine induced anxiety0.00.10.2-0.20.5-0.3
Post-drug Anxiety0.20.30.50.70.1-0.5
Baseline Anxiety0.20.30.70.8-0.6-0.1
Tail length0.63.04.82.2-1.90.8
Length with tail1.25.312.03.5-2.0-0.1
Length without tail0.62.96.72.6-1.4-0.3
Times rat made contact with spout0.60.71.20.50.8-1.1
Lifetime Intake1.01.21.8-1.31.3-0.5
Liver weight, left0.40.81.3-0.5-0.91.1
Liver weight, right0.61.11.6-1.3-0.61.2
Locomotor activity0.71.21.9-1.4-0.31.2
Locomotor testing distance0.51.32.1-1.5-0.51.3
Locomotor testing rearing0.31.22.6-1.60.9-0.0
Locomotion in novel chamber2.43.27.6-2.81.30.6
Locomotion in novel chamber post-restriction0.72.25.4-2.30.70.9
Fecal boli incidents, locomotor time 10.00.10.2-0.40.10.1
Change in fecal boli incidents, locomotor task0.10.10.30.50.1-0.4
Time >=10cm from walls, locomotor time 11.61.93.5-1.11.9-1.0
Bouts of movement, locomotor time 11.01.31.71.3-1.30.7
Total resting periods, locomotor time 10.80.91.30.9-1.10.8
Rest time, locomotor task time 11.01.62.5-1.6-0.61.4
Distance moved, locomotor task time 10.41.32.10.21.3-1.5
Vertical activity count, locomotor time 10.10.71.1-0.91.0-0.5
Time >=10cm from walls, locomotor time 20.10.20.4-0.2-0.40.6
Bouts of movement, locomotor time 20.10.30.90.9-0.3-0.1
Total resting periods, locomotor time 20.00.10.40.6-0.0-0.2
Rest time, locomotor task time 21.01.73.2-1.81.3-0.1
Distance moved, locomotor task time 20.70.91.41.1-1.20.4
Vertical activity count, locomotor time 20.92.13.70.4-1.91.5
Light reinforcement 10.20.71.3-1.1-0.30.9
Light reinforcement 20.81.94.0-2.0-0.11.3
Bone: marrow area0.92.23.7-1.51.9-0.9
Bone: maximum diameter0.10.20.4-0.6-0.00.4
Bone: maximum force1.63.25.31.41.6-2.3
Bone: maximum moment1.52.84.51.41.4-2.1
Mean time between licks in bursts0.10.51.21.1-0.4-0.1
Mean num. licks in bursts0.00.10.30.10.3-0.5
Cd content in liver0.70.82.1-1.50.50.4
Co content in liver1.82.13.3-0.8-1.51.8
Cu content in liver0.00.00.0-0.0-0.20.1
Fe content in liver0.00.00.10.3-0.2-0.0
K content in liver0.40.40.70.40.6-0.9
Mg content in liver0.50.50.7-0.80.8-0.4
Mn content in liver0.80.92.41.6-0.2-0.6
Na content in liver0.50.61.0-0.1-0.91.0
Rb content in liver1.11.31.7-1.31.3-0.8
Se content in liver0.30.30.5-0.20.7-0.6
Sr content in liver1.31.22.11.5-1.10.5
Zn content in liver0.40.50.70.8-0.80.3
Bone: minimum diameter1.63.05.1-1.42.3-1.4
Time in familiar zone, hab. session 10.40.50.7-0.80.8-0.4
Time in novel zone, hab. session 10.10.10.20.4-0.40.3
Total zone transitions, hab. session 10.20.30.50.40.5-0.7
Total locomotion distance, hab. session 10.40.61.2-1.10.7-0.1
Locomotion velocity, hab. session 10.20.30.6-0.80.5-0.1
Time in familiar zone, hab. session 20.50.60.90.8-1.00.5
Time in novel zone, hab. session 20.80.91.4-0.21.2-1.1
Total zone transitions, hab. session 23.54.57.50.92.3-2.7
Total locomotion distance, hab. session 21.31.72.7-0.31.6-1.5
Locomotion velocity, hab. session 21.21.62.8-0.61.7-1.3
Novel to familiar place preference ratio0.30.40.70.50.6-0.9
Novelty place preference0.30.40.60.20.7-0.8
Time in novel zone, NPP test0.40.40.70.20.8-0.8
Total zone transitions, NPP test1.01.52.30.91.1-1.5
Total locomotion distance, NPP test0.40.50.9-0.30.9-0.7
Locomotion velocity, NPP test0.20.30.6-0.30.8-0.5
Intraocular pressure0.91.52.2-1.0-1.11.5
Delta distance traveled before/after self-admin0.10.10.20.2-0.40.4
Delta ambulatory time before/after self-admin0.10.20.40.3-0.60.4
Parametrial fat weight1.33.17.3-2.71.40.3
Pavlov. Cond. lever latency0.20.20.3-0.6-0.30.5
Pavlov. Cond. magazine entry latency0.60.81.4-0.11.2-1.0
Pavlov. Cond. change in total contacts0.50.50.8-0.70.9-0.4
Pavlov. Cond. index score0.10.10.1-0.30.3-0.0
Pavlov. Cond. latency score0.10.10.2-0.10.5-0.3
Pavlov. Cond. lever contacts0.10.10.10.10.4-0.3
Pavlov. Cond. magazine entry number0.00.00.00.2-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.0-0.5-0.81.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.30.4-0.1
Pavlov. Cond. response bias0.00.00.1-0.20.10.2
Pavlov. Cond. lever latency0.00.00.10.3-0.2-0.1
Pavlov. Cond. magazine entry latency2.13.04.81.71.1-2.2
Pavlov. Cond. change in total contacts0.40.91.30.31.1-1.1
Pavlov. Cond. index score0.61.01.60.70.9-1.3
Pavlov. Cond. latency score0.40.71.10.60.8-1.1
Pavlov. Cond. lever contacts0.00.10.1-0.20.3-0.1
Pavlov. Cond. magazine entry number2.73.55.3-2.0-1.12.3
Pavlov. Cond. intertrial magazine entries0.30.71.1-1.0-0.51.0
Pavlov. Cond. lever-magazine prob. diff.0.71.11.80.90.9-1.4
Pavlov. Cond. response bias0.71.01.70.60.9-1.3
Time in closed arm before self-admin0.40.71.1-1.01.0-0.4
Time in closed arm after self-admin0.00.10.1-0.2-0.20.3
Time in open arm before self-admin0.70.81.30.9-1.10.5
Time in open arm after self-admin0.30.30.50.70.1-0.6
Bone: periosteal estimation0.10.20.3-0.50.6-0.1
Bone: periosteal perimeter0.30.71.2-0.41.1-0.8
Bone: post-yield work5.69.716.1-0.54.0-3.6
Progressive ratio test 1 active lever presses0.00.10.1-0.1-0.30.3
Progressive ratio test 1 breakpoint0.00.10.1-0.0-0.30.3
Progressive ratio test 1 inactive lever presses0.00.00.0-0.1-0.10.1
Progressive ratio test 2 active lever presses0.60.82.0-1.40.60.2
Progressive ratio test 2 breakpoint0.60.81.9-1.40.50.2
Progressive ratio test 2 inactive lever presses1.23.99.8-3.11.30.6
Incentive Sensitization - Responses0.20.71.10.00.9-1.0
Incentive Sensitization - Breakpoint0.30.60.9-0.21.0-0.9
Sum of active levers in priming session hrs 5-63.02.94.3-0.1-2.12.1
Progressive ratio1.64.77.51.22.3-2.7
Food seeking constrained by brief footshock0.10.20.30.50.2-0.4
Seeking ratio, punishment vs. effort1.22.74.5-1.1-1.62.1
Retroperitoneal fat weight3.515.739.4-6.31.62.3
Reaction time number correct0.10.40.70.4-0.90.6
Reaction time mean minus median0.21.01.61.10.4-1.3
Reaction time mean minus median AUC0.10.40.80.9-0.1-0.6
Reaction time num false alarms0.61.01.50.2-1.21.2
Reaction time num false alarms AUC0.40.91.40.9-1.20.7
Reaction time trials correct on left0.10.40.70.4-0.90.6
Reaction time trials on left0.10.50.90.5-0.90.6
Reaction time mean0.20.40.6-0.10.8-0.8
Reaction time mean AUC0.20.50.8-0.20.9-0.8
Median of all reaction times0.40.61.0-0.41.0-0.8
Reaction time omissions0.61.02.31.5-0.2-0.7
Reaction time false alarm rate0.30.40.70.5-0.80.6
Reaction time premature initiation rate1.21.84.62.1-0.5-0.8
Reaction time premature initiations0.82.45.62.4-1.2-0.3
Std. dev. reaction times0.10.40.80.60.4-0.9
Reaction time trials completed0.10.50.90.5-0.90.6
Reaction time trials AUC0.10.40.70.4-0.80.5
Run reversals in cocaine runway, females1.01.11.70.90.9-1.3
Run reversals in cocaine runway, males0.50.61.00.1-1.00.9
Latency to leave start box in cocaine runway0.81.12.0-0.41.4-1.1
Latency to leave start box in cocaine runway, F0.70.91.6-0.21.3-1.1
Latency to leave start box in cocaine runway, M0.00.00.10.10.2-0.2
Std. dev. time between licks in bursts0.81.62.70.9-1.71.1
Total sessions with >9 infusions0.10.20.30.40.3-0.6
Short access day 1 total inactive lever presses0.40.92.2-1.50.40.5
Short access day 10 total inactive lever presses0.00.00.0-0.00.1-0.2
Short access day 1 total infusions0.20.41.0-1.00.6-0.1
Short access day 10 total infusions1.01.72.7-0.11.6-1.5
Short access total infusions0.40.50.8-0.00.9-0.9
Short access day 1 locomotion0.30.51.1-1.00.70.0
Short access day 10 total locomotion0.20.71.2-0.81.1-0.4
Short access total locomotion0.40.60.9-1.00.9-0.2
One hour access (0.3 mA shock)2.02.45.8-2.41.10.5
Compulsive drug intake1.52.24.02.0-1.50.3
One hour access (shock baseline)1.54.010.0-3.21.20.7
Social response proportion0.40.50.90.50.5-0.9
Social responses0.10.10.20.5-0.50.1
Social time0.10.20.40.6-0.1-0.5
Soleus weight2.16.110.7-3.3-0.82.6
Bone: stiffness1.52.84.50.91.7-2.1
Tibialis anterior weight4.114.128.55.3-3.70.6
Time to tail flick, vehicle, before self-admin1.11.42.30.41.3-1.5
Time to tail flick, vehicle, after self-admin1.02.13.51.21.2-1.9
Time to tail flick, test, before self-admin1.61.93.4-0.81.8-1.3
Time to tail flick, test, after self-admin0.10.10.10.2-0.30.2
Delta time to tail flick, vehicle, before/after SA0.40.50.80.90.3-0.7
Delta time to tail flick, test, before/after SA3.13.86.81.1-2.61.9
Tibia length0.51.52.40.3-1.61.4
Ambulatory time before self-admin0.20.71.2-0.11.1-1.0
Ambulatory time after self-admin0.61.01.6-0.91.3-0.7
Bone: tissue strength0.50.50.7-0.80.9-0.4
Total heroin consumption1.92.25.52.4-0.7-0.8
Bone: trabecular number2.14.06.30.62.3-2.5
Bone: trabecular spacing0.71.01.5-0.2-1.21.2
Bone: trabecular thickness1.41.93.4-0.71.8-1.4
Bone: trabecular tissue density3.05.28.3-2.9-0.82.6
Water consumed over 24 hours0.50.91.31.10.6-1.1
Number of responses in last shaping day0.10.10.20.3-0.50.2