Hub : Genes

Gadd45b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Gadd45b	0.04	0.03	9.4e-06	0.05	0.05	0.05	0.05	2.9e-06	6.1e-06	6.0e-06	2.6e-06
2	Brain	gene expression	Gadd45b	0.07	0.05	3.1e-06	0.06	0.06	0.05	0.06	7.1e-06	6.9e-06	1.1e-05	6.8e-06
3	NAcc	gene expression	Gadd45b	0.06	0.05	7.9e-07	0.06	0.05	0.05	0.05	3.0e-07	6.1e-07	2.4e-06	7.1e-07
4	Liver	gene expression	Gadd45b	0.06	0.05	2.2e-03	0.01	0.01	0.02	0.01	1.1e-02	1.9e-02	4.8e-03	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.0	1.7	5.8	0.7	0.6	-0.6	-2.4
Area under the delay curve	1.8	1.9	2.9	1.7	1.4	-1.5	-0.6
BMI with tail	4.9	15.8	21.2	4.5	4.6	-4.6	-0.8
BMI without tail	1.6	3.3	4.3	1.9	2.0	-2.1	1.0
Body weight	0.9	3.8	5.3	2.1	2.3	-2.3	-0.2
Weight adjusted by age	0.4	0.4	1.4	0.3	0.4	-0.4	1.2
Bone surface	1.5	2.6	10.1	0.4	0.3	-0.2	-3.2
Bone volume	1.5	2.5	9.6	0.4	0.3	-0.3	-3.1
Breakpoint value in progressive ratio session	5.2	5.8	6.9	-2.6	-2.6	2.5	1.7
Number of licking bursts	0.3	0.4	1.4	-0.2	-0.2	0.2	1.2
Context. condit. distance diff. score	0.2	0.3	0.3	0.6	0.6	-0.6	0.2
Locomotion velocity, session 1	0.5	0.5	1.3	-0.4	-0.5	0.5	-1.1
Locomotion distance, session 1	1.2	1.5	6.1	0.2	0.1	-0.1	-2.5
Locomotion velocity, session 2	2.4	2.8	3.0	-1.6	-1.7	1.7	-1.7
Locomotion distance, session 2	1.5	2.1	5.5	-1.0	-1.0	1.0	-2.3
Locomotion velocity, session 3	5.4	6.3	8.2	-2.7	-2.9	2.9	1.2
Locomotion distance, session 3	0.1	0.1	0.2	0.0	-0.0	0.0	0.5
Stereotopy head waving bouts, day 3	3.3	3.9	5.3	-2.3	-2.3	2.3	-0.2
Stereotopy head waving duration, day 3	4.3	5.1	7.0	-2.6	-2.6	2.6	0.3
Locomotion velocity, session 7	0.5	0.6	0.7	-0.8	-0.7	0.7	0.7
Locomotion distance, session 7	0.3	0.4	1.5	0.1	0.2	-0.2	1.2
Stereotopy head waving bouts, day 7	0.4	0.4	1.6	0.3	0.2	-0.2	-1.3
Stereotopy head waving duration, day 7	0.4	0.5	1.8	-0.1	-0.2	0.2	-1.3
Locomotion velocity, session 8	0.8	0.9	3.3	-0.3	-0.4	0.4	-1.8
Locomotion distance, session 8	0.2	0.2	0.9	-0.2	-0.2	0.2	-0.9
Degree of sensitization distance	0.3	0.3	0.5	0.6	0.7	-0.7	-0.2
Degree of sensitization stereotypy	2.2	2.4	2.8	1.7	1.6	-1.6	-1.3
Conditioned locomotion	0.8	0.9	1.0	0.9	1.0	-0.9	1.0
Cocaine response after cond. corrected	3.1	3.5	4.3	2.0	2.1	-2.0	1.2
Cocaine response after cond. not corrected	3.3	3.6	4.4	2.1	2.1	-2.1	1.3
Cocaine response before conditioning	0.3	0.3	0.5	-0.7	-0.7	0.6	0.1
Saline control response	0.0	0.0	0.0	0.1	0.2	-0.2	0.1
Bone: connectivity density	1.0	1.6	3.8	1.0	0.9	-0.8	-1.9
Bone: cortical apparent density	0.6	0.8	1.0	1.0	1.0	-1.0	-0.3
Bone: cortical area	0.9	1.3	1.4	1.1	1.1	-1.1	-1.2
Bone: cortical porosity	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.6
Bone: cortical porosity	0.4	0.5	1.9	0.1	0.2	-0.1	-1.4
Bone: cortical thickness	1.2	2.0	2.3	1.5	1.5	-1.5	-1.0
Bone: cortical thickness	0.4	0.5	1.6	-0.3	-0.2	0.2	1.3
Bone: cortical tissue density	0.4	0.5	0.7	0.8	0.8	-0.8	-0.2
Condit. Reinf. active minus inactive responses	3.3	3.7	5.0	-2.1	-2.2	2.2	0.6
Condit. Reinf. active-inactive response ratio	2.4	2.6	2.9	-1.6	-1.7	1.7	1.3
Condit. Reinf. active responses	2.4	2.9	3.9	-1.9	-2.0	2.0	-0.6
Condit. Reinf. inactive responses	0.8	1.0	2.5	-0.6	-0.7	0.7	-1.6
Incentive salience index mean	1.4	1.7	2.2	-1.4	-1.5	1.5	-0.5
Condit. Reinf. lever presses	1.1	1.5	5.5	0.4	0.3	-0.3	-2.3
Condit. Reinf. active minus inactive responses	2.7	3.3	3.6	-1.9	-1.9	1.9	1.6
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.8	-0.6	-0.6	0.7	1.3
Condit. Reinf. active responses	2.1	2.9	3.3	-1.8	-1.8	1.8	1.2
Condit. Reinf. inactive responses	0.8	1.0	1.2	-1.1	-1.1	1.1	0.6
Condit. Reinf. lever presses	2.6	3.5	4.0	-2.0	-1.9	1.9	1.6
Condit. Reinf. lever reinforcers received	1.9	2.6	2.8	-1.7	-1.7	1.7	1.5
Conditioned reinforcement - actives	1.5	1.5	2.6	-1.6	-1.2	1.3	0.5
Conditioned reinforcement - inactives	0.3	0.4	0.7	0.6	0.8	-0.7	0.3
Conditioned locomotion	5.6	6.8	9.1	-3.0	-2.9	2.9	1.0
Patch foraging indifference point 0 sec	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5
Patch foraging indifference point AUC	0.8	0.9	1.2	-1.1	-1.0	1.0	0.6
Delay disc. indifference point, 0s delay	8.7	9.5	9.6	3.1	3.1	-3.1	-3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.5	0.3	-0.4	-0.2
Delay disc. indifference point, 2s delay	5.1	5.6	7.3	2.7	2.5	-2.6	-1.4
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	0.9	0.8	-0.9	0.2
Delay disc. indifference point, 4s delay	1.1	1.1	1.8	1.3	0.9	-1.0	-0.9
Delay disc. indifference point, 8s delay	0.7	0.7	1.1	1.0	0.9	-0.9	0.2
Indifference point function ln k	0.2	0.2	0.3	0.6	0.5	-0.5	0.2
Indifference point function log k	0.2	0.2	0.3	0.6	0.5	-0.5	0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.3	0.4	-0.4	0.6
Patch foraging total patch changes 18 sec	1.0	1.2	1.6	-1.2	-1.3	1.3	0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1
Patch foraging total patch changes 6 sec	0.2	0.2	0.3	-0.6	-0.6	0.5	-0.1
Patch foraging time to switch 0 sec	2.5	3.8	6.3	1.7	1.7	-1.8	-2.5
Patch foraging water rate 0 sec	0.9	1.5	5.3	-0.4	-0.5	0.5	2.3
Patch foraging water rate 12 sec	0.8	1.2	3.1	0.8	0.8	-0.8	1.8
Patch foraging water rate 18 sec	2.5	3.4	10.9	-0.8	-0.9	1.0	3.3
Patch foraging water rate 24 sec	1.5	2.1	8.4	0.0	-0.1	0.1	2.9
Patch foraging water rate 6 sec	1.6	2.3	5.9	-1.0	-1.0	1.0	2.4
Seeking ratio, delayed vs. immediate footshock	2.9	3.4	4.6	-2.1	-2.1	2.1	0.2
Distance traveled before self-admin	0.8	0.8	1.0	0.8	1.0	-0.9	-0.9
Distance traveled after self-admin	0.3	0.3	0.6	-0.8	-0.6	0.6	-0.1
Extensor digitorum longus weight	3.2	12.6	17.0	4.1	4.1	-4.1	0.2
Bone: elastic displacement	0.1	0.2	0.2	-0.5	-0.5	0.4	-0.1
Bone: elastic work	0.3	0.3	0.4	0.6	0.6	-0.6	-0.4
Bone: endosteal estimation	0.2	0.5	0.6	0.8	0.7	-0.7	-0.6
Bone: endosteal perimeter	0.1	0.2	0.3	-0.4	-0.5	0.5	-0.5
Epididymis fat weight	0.3	0.8	0.9	-0.8	-1.0	1.0	0.7
Delta time in closed arm before/after self-admin	1.1	1.0	3.7	0.3	0.4	-0.4	1.9
Delta time in open arm before/after self-admin	1.2	1.1	1.5	1.2	1.0	-1.1	-0.9
Diff in mean of infusions in LGA sessions	1.6	1.8	2.5	-1.4	-1.6	1.5	0.6
Delay discount exponential model param	1.6	1.7	2.6	-1.6	-1.3	1.4	0.5
Extinction: sum of active levers before priming	1.7	1.7	2.3	-1.4	-1.2	1.1	1.5
Active lever presses in extinction session 6	1.9	1.8	2.8	-1.7	-1.5	1.4	0.3
Bone: final force	1.4	2.2	2.7	1.6	1.6	-1.5	-1.1
Bone: final moment	1.1	1.8	2.1	1.4	1.5	-1.4	-1.0
Food consumed during 24 hour testing period	0.4	0.4	0.7	0.8	0.7	-0.7	0.2
Glucose	1.0	1.5	2.1	1.4	1.4	-1.4	-0.1
Heart weight	0.6	0.8	1.2	-0.8	-0.8	0.8	1.1
Delay discount hyperbolic model param	2.3	2.4	3.6	-1.9	-1.6	1.7	0.7
Intermittent access intake day 1-15 change	5.6	5.5	7.6	-2.7	-2.5	2.5	1.3
Intermittent access intake escalation	6.6	6.5	8.1	-2.8	-2.6	2.6	2.1
Intermittent access intake escalation 2	8.3	8.2	9.9	-3.2	-3.0	2.9	2.4
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.2	-0.6	-0.4	0.4	1.1
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.7	-0.8	-0.8	0.8	0.5
Intermitt. access escalation Index	0.9	0.8	1.7	0.7	0.7	-0.8	-1.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.2	-0.1	-0.2
Intermittent access day 15 total infusions	2.0	2.3	3.0	-1.7	-1.6	1.6	1.1
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.6	-1.3	-1.1	1.0	0.7
Intermittent access total infusions	0.2	0.3	0.4	-0.6	-0.5	0.5	0.4
Intermittent access day 1 locomotion	0.4	0.4	0.5	-0.7	-0.6	0.7	0.3
Intermittent access day 15 total locomotion	2.8	3.0	4.3	-2.1	-1.9	1.9	0.7
Intermittent access total locomotion	0.6	0.7	1.2	-1.1	-0.9	0.9	0.1
Intermittent access standard deviation	2.7	2.9	4.0	-2.0	-1.7	1.7	1.2
Left kidney weight	0.1	0.2	0.6	-0.1	0.0	-0.1	-0.8
Right kidney weight	1.0	2.7	3.9	-2.0	-1.8	1.8	0.4
Cocaine induced anxiety	0.4	0.5	1.3	-0.6	-0.4	0.4	-1.1
Post-drug Anxiety	0.4	0.5	1.3	-0.5	-0.5	0.5	-1.1
Baseline Anxiety	0.5	0.5	1.1	-0.4	-0.6	0.6	1.1
Tail length	2.8	8.4	10.6	-3.3	-3.1	3.1	1.8
Length with tail	1.3	4.7	6.7	-2.6	-2.4	2.4	0.4
Length without tail	0.2	0.4	1.8	-0.0	0.0	0.0	-1.3
Times rat made contact with spout	0.1	0.2	0.5	0.3	0.3	-0.3	0.7
Lifetime Intake	0.1	0.1	0.2	-0.4	-0.2	0.3	0.1
Liver weight, left	1.6	2.5	3.5	1.9	1.8	-1.8	-0.2
Liver weight, right	1.6	2.6	3.2	1.7	1.8	-1.8	-1.0
Locomotor activity	1.9	3.1	4.3	-2.1	-2.0	1.9	-0.6
Locomotor testing distance	1.3	2.1	3.0	-1.7	-1.7	1.7	-0.1
Locomotor testing rearing	0.2	0.3	0.9	-0.4	-0.3	0.3	1.0
Locomotion in novel chamber	0.3	0.4	0.5	-0.7	-0.6	0.5	0.6
Locomotion in novel chamber post-restriction	1.0	1.2	1.4	-1.1	-1.2	1.2	1.0
Fecal boli incidents, locomotor time 1	1.5	1.7	2.7	1.1	1.6	-1.7	-0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.4	-0.1	0.1	-0.0
Time >=10cm from walls, locomotor time 1	1.3	1.3	1.9	0.7	1.2	-1.2	-1.4
Bouts of movement, locomotor time 1	0.2	0.2	0.2	-0.5	-0.3	0.4	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.5	-0.3	0.4	0.3
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.2
Distance moved, locomotor task time 1	1.0	1.1	1.4	0.9	0.9	-1.1	-1.2
Vertical activity count, locomotor time 1	0.2	0.2	0.6	0.1	0.2	-0.3	0.8
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.6	1.0	1.3	-1.2	0.2
Bouts of movement, locomotor time 2	0.5	0.5	1.1	-0.3	-0.6	0.7	-1.0
Total resting periods, locomotor time 2	0.5	0.5	1.2	-0.2	-0.6	0.7	-1.1
Rest time, locomotor task time 2	0.3	0.4	0.5	-0.6	-0.7	0.7	-0.5
Distance moved, locomotor task time 2	0.4	0.5	0.7	0.8	0.8	-0.8	0.2
Vertical activity count, locomotor time 2	0.4	0.5	0.7	0.5	0.7	-0.7	0.9
Light reinforcement 1	4.1	7.4	10.1	-3.1	-3.2	3.1	0.2
Light reinforcement 2	1.3	1.8	2.4	-1.5	-1.6	1.5	-0.1
Bone: marrow area	0.2	0.5	0.6	0.8	0.7	-0.7	-0.6
Bone: maximum diameter	0.4	0.7	0.7	-0.8	-0.8	0.8	-0.8
Bone: maximum force	1.2	2.0	2.6	1.6	1.6	-1.5	-0.8
Bone: maximum moment	0.9	1.6	2.1	1.4	1.4	-1.4	-0.7
Mean time between licks in bursts	3.8	5.4	6.7	-2.6	-2.6	2.6	1.3
Mean num. licks in bursts	0.1	0.1	0.2	0.3	0.3	-0.4	-0.4
Cd content in liver	0.2	0.2	0.2	0.5	0.5	-0.5	-0.4
Co content in liver	0.5	0.6	0.8	-0.9	-0.9	0.9	0.5
Cu content in liver	0.5	0.7	1.7	0.6	0.6	-0.6	-1.3
Fe content in liver	0.1	0.1	0.3	-0.3	-0.3	0.3	0.6
K content in liver	0.6	0.6	2.1	0.3	0.3	-0.3	-1.4
Mg content in liver	0.6	0.7	2.2	0.4	0.4	-0.4	-1.5
Mn content in liver	0.9	1.1	3.7	-0.4	-0.5	0.5	-1.9
Na content in liver	1.8	1.9	2.8	1.3	1.2	-1.2	-1.7
Rb content in liver	1.1	1.3	2.6	0.9	0.9	-0.9	-1.6
Se content in liver	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.2
Sr content in liver	0.4	0.4	1.3	-0.2	-0.3	0.3	1.1
Zn content in liver	3.3	3.6	5.1	-1.7	-1.8	1.8	2.3
Bone: minimum diameter	0.1	0.1	0.4	0.3	0.3	-0.2	-0.6
Time in familiar zone, hab. session 1	2.7	2.5	2.8	-1.6	-1.7	1.7	1.4
Time in novel zone, hab. session 1	1.8	1.7	2.0	1.3	1.3	-1.3	-1.4
Total zone transitions, hab. session 1	0.8	1.1	2.6	-0.8	-0.8	0.8	-1.6
Total locomotion distance, hab. session 1	1.1	1.6	4.8	-0.7	-0.7	0.7	-2.2
Locomotion velocity, hab. session 1	1.2	1.8	3.8	-1.0	-1.0	1.0	-2.0
Time in familiar zone, hab. session 2	6.7	6.9	7.8	-2.8	-2.8	2.8	2.1
Time in novel zone, hab. session 2	5.2	5.1	5.8	2.4	2.4	-2.4	-1.8
Total zone transitions, hab. session 2	2.0	2.6	8.7	0.8	0.7	-0.7	-2.9
Total locomotion distance, hab. session 2	1.0	1.3	3.1	-0.8	-0.8	0.8	-1.8
Locomotion velocity, hab. session 2	1.2	1.7	5.1	-0.7	-0.7	0.7	-2.3
Novel to familiar place preference ratio	5.4	5.5	5.9	2.4	2.4	-2.4	-2.1
Novelty place preference	3.6	3.6	3.7	1.9	1.9	-1.9	-1.9
Time in novel zone, NPP test	3.7	3.9	4.2	2.0	2.0	-2.0	-1.8
Total zone transitions, NPP test	0.8	1.1	4.3	0.2	0.2	-0.2	-2.1
Total locomotion distance, NPP test	0.9	1.2	4.4	0.4	0.4	-0.4	-2.1
Locomotion velocity, NPP test	0.7	1.0	4.1	0.1	0.1	-0.1	-2.0
Intraocular pressure	0.8	1.1	3.8	-0.5	-0.5	0.5	1.9
Delta distance traveled before/after self-admin	1.4	1.5	2.1	-1.4	-1.5	1.3	0.5
Delta ambulatory time before/after self-admin	1.3	1.5	2.0	-1.4	-1.4	1.4	0.2
Parametrial fat weight	0.4	0.9	1.1	-1.0	-0.9	0.8	0.9
Pavlov. Cond. lever latency	0.5	0.6	2.1	-0.3	-0.3	0.3	1.4
Pavlov. Cond. magazine entry latency	2.6	3.3	4.3	-2.0	-2.1	2.1	0.8
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3
Pavlov. Cond. index score	0.3	0.4	0.5	-0.5	-0.6	0.6	-0.7
Pavlov. Cond. latency score	0.4	0.4	1.2	-0.4	-0.5	0.5	-1.1
Pavlov. Cond. lever contacts	0.6	0.7	2.6	0.2	0.1	-0.1	-1.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	0.9	1.0	-1.0	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-0.6	-0.6	0.6	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.8	-0.9	0.9	-0.5
Pavlov. Cond. response bias	0.9	1.1	1.5	-1.1	-1.2	1.2	0.1
Pavlov. Cond. lever latency	0.7	0.9	1.2	1.1	1.0	-1.0	-0.8
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.7	-0.6	0.6	0.4
Pavlov. Cond. change in total contacts	0.8	1.1	1.2	-1.1	-1.1	1.1	0.9
Pavlov. Cond. index score	0.8	1.1	1.3	-1.2	-1.0	1.0	0.9
Pavlov. Cond. latency score	0.6	0.8	1.1	-1.1	-0.9	0.9	0.6
Pavlov. Cond. lever contacts	0.9	1.2	1.4	-1.2	-1.0	1.0	1.2
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	0.9	0.9	-0.9	-0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.4	0.4	-0.4	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.3	-1.1	-1.0	1.0	0.7
Pavlov. Cond. response bias	1.9	2.6	3.0	-1.7	-1.6	1.6	1.5
Time in closed arm before self-admin	1.7	1.9	3.7	1.2	1.2	-1.1	-1.9
Time in closed arm after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3
Time in open arm before self-admin	0.7	0.8	1.0	-1.0	-0.8	0.9	0.9
Time in open arm after self-admin	0.5	0.6	0.9	1.0	0.9	-0.8	-0.2
Bone: periosteal estimation	0.6	1.2	1.6	1.1	1.0	-1.0	-1.3
Bone: periosteal perimeter	0.1	0.2	0.8	0.0	0.0	0.1	-0.9
Bone: post-yield work	0.3	0.5	0.7	0.8	0.8	-0.7	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.1	0.1	-0.1	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.3	0.2	-0.2	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.2
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.6	-0.3	0.4	0.8
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.6	-0.3	0.4	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.3	0.0	0.0	-0.3
Incentive Sensitization - Responses	0.3	0.3	0.9	-0.6	-0.2	0.2	1.0
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	-0.6	-0.3	0.3	0.9
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2
Progressive ratio	0.1	0.1	0.1	0.4	0.4	-0.3	-0.0
Food seeking constrained by brief footshock	0.1	0.2	0.2	-0.4	-0.3	0.4	-0.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.4	-0.4	0.4	-0.4
Retroperitoneal fat weight	0.2	0.5	0.8	0.9	0.8	-0.8	0.0
Reaction time number correct	0.6	0.8	2.5	0.6	0.5	-0.4	1.6
Reaction time mean minus median	0.7	1.0	1.1	-1.0	-1.0	1.0	0.8
Reaction time mean minus median AUC	0.1	0.2	0.6	0.2	0.2	-0.1	-0.8
Reaction time num false alarms	0.4	0.5	2.0	0.1	0.1	-0.1	1.4
Reaction time num false alarms AUC	0.5	0.6	2.5	0.2	0.1	-0.1	1.6
Reaction time trials correct on left	0.6	0.8	2.5	0.6	0.5	-0.4	1.6
Reaction time trials on left	0.5	0.8	2.2	0.6	0.5	-0.5	1.5
Reaction time mean	0.1	0.1	0.2	0.2	0.2	-0.2	-0.5
Reaction time mean AUC	0.1	0.1	0.3	0.3	0.3	-0.3	-0.5
Median of all reaction times	0.4	0.6	0.7	0.7	0.7	-0.7	-0.8
Reaction time omissions	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.4
Reaction time false alarm rate	0.0	0.0	0.1	0.1	0.1	-0.1	0.3
Reaction time premature initiation rate	1.4	1.9	2.1	-1.4	-1.4	1.4	1.2
Reaction time premature initiations	1.7	2.4	4.6	-1.2	-1.3	1.3	2.1
Std. dev. reaction times	0.1	0.2	0.2	-0.5	-0.5	0.5	0.2
Reaction time trials completed	0.5	0.8	2.2	0.6	0.5	-0.5	1.5
Reaction time trials AUC	0.6	0.9	3.1	0.5	0.4	-0.4	1.8
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.1
Run reversals in cocaine runway, males	1.1	1.0	1.5	-1.1	-1.2	1.2	-0.2
Latency to leave start box in cocaine runway	0.5	0.6	1.2	-0.7	-0.6	0.5	-1.1
Latency to leave start box in cocaine runway, F	1.2	1.3	4.3	0.3	0.6	-0.7	-2.1
Latency to leave start box in cocaine runway, M	3.3	3.2	3.5	-1.8	-1.8	1.9	1.7
Std. dev. time between licks in bursts	0.4	0.5	0.6	-0.8	-0.8	0.8	-0.0
Total sessions with >9 infusions	0.1	0.1	0.3	0.1	0.4	-0.3	-0.5
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.2	-0.1	0.2	-0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.2	-0.2	0.2	0.5
Short access day 1 total infusions	0.2	0.2	0.7	-0.2	-0.1	0.1	-0.9
Short access day 10 total infusions	0.1	0.1	0.1	-0.2	-0.2	0.3	0.4
Short access total infusions	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.3
Short access day 1 locomotion	0.5	0.5	0.9	-0.9	-0.7	0.8	-0.4
Short access day 10 total locomotion	3.2	3.6	5.1	-2.3	-2.0	2.1	1.1
Short access total locomotion	0.5	0.5	1.0	-1.0	-0.7	0.8	0.1
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.4	0.5	-0.3	-0.2
Compulsive drug intake	1.5	1.5	1.9	1.2	1.4	-1.3	-1.0
One hour access (shock baseline)	0.2	0.3	0.5	-0.5	-0.4	0.5	0.7
Social response proportion	0.5	0.6	0.6	-0.7	-0.7	0.7	-0.8
Social responses	4.6	5.9	8.2	-2.9	-2.8	2.8	0.2
Social time	0.5	0.7	0.8	0.8	0.9	-0.9	-0.7
Soleus weight	7.1	20.7	27.3	5.2	5.2	-5.2	-1.1
Bone: stiffness	2.7	4.2	5.4	2.3	2.3	-2.3	-1.0
Tibialis anterior weight	1.0	3.4	4.5	2.1	2.1	-2.1	-0.4
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.0	-0.4	-0.5	0.5	-1.0
Time to tail flick, vehicle, after self-admin	0.9	0.9	2.3	-0.5	-0.8	0.7	1.5
Time to tail flick, test, before self-admin	0.3	0.3	1.1	-0.2	-0.1	0.2	-1.0
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.3	-0.7	0.7	-0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	2.6	0.2	0.2	-0.2	1.6
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.5	-0.7	0.6	0.9
Tibia length	0.8	2.3	3.0	-1.7	-1.7	1.7	0.7
Ambulatory time before self-admin	0.6	0.6	0.7	0.7	0.9	-0.8	-0.7
Ambulatory time after self-admin	0.1	0.2	0.3	-0.6	-0.4	0.4	-0.3
Bone: tissue strength	1.6	1.6	1.9	1.3	1.4	-1.4	-0.9
Total heroin consumption	1.5	1.8	2.4	-1.5	-1.5	1.5	0.5
Bone: trabecular number	0.4	0.6	1.5	-0.5	-0.6	0.6	-1.2
Bone: trabecular spacing	1.0	1.3	5.3	0.1	0.1	-0.1	2.3
Bone: trabecular thickness	2.5	3.0	10.3	0.7	0.7	-0.7	-3.2
Bone: trabecular tissue density	0.9	1.3	1.9	1.3	1.4	-1.3	-0.0
Water consumed over 24 hours	0.8	1.0	1.1	1.0	1.0	-1.0	-1.0
Number of responses in last shaping day	0.1	0.1	0.2	-0.5	-0.1	0.2	0.1