Hub : Genes

Gad1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr3_55369816_55371254 0.05 0.04 1.1e-03 0.04 0.04 0.02 0.03 1.3e-04 2.9e-04 6.0e-03 6.2e-04
2 PL mRNA stability Gad1 0.02 0.01 8.5e-03 0.01 0.01 0.01 0.01 1.2e-02 7.2e-03 1.3e-02 1.1e-02
3 Brain mRNA stability Gad1 0.18 0.08 0.0e+00 0.2 0.24 0.23 0.23 5.6e-18 5.4e-22 4.4e-21 1.5e-21
4 NAcc mRNA stability Gad1 0.14 0.08 2.8e-16 0.15 0.12 0.14 0.14 1.2e-16 2.9e-14 1.4e-15 6.3e-16
5 LHb gene expression Gad1 0.31 0.14 1.5e-05 0.11 0.13 0.11 0.14 1.2e-03 5.1e-04 1.5e-03 4.2e-04
6 pVTA mRNA stability Gad1 0.13 0.09 1.2e-03 0.04 0.05 0.04 0.04 4.8e-03 2.4e-03 4.8e-03 9.3e-03
7 Brain gene expression Gad1 0.17 0.08 1.8e-08 0.08 0.09 0.1 0.1 1.3e-07 5.2e-09 8.6e-10 1.2e-09
8 OFC gene expression Gad1 0.38 0.18 6.2e-04 0.13 0.09 0.12 0.11 6.5e-04 3.9e-03 6.9e-04 1.5e-03
9 PL gene expression Gad1 0.45 0 1.8e-09 0.09 0.09 0.08 0.09 2.3e-10 5.9e-10 2.8e-09 3.6e-10
10 IL gene expression Gad1 0.4 0.16 1.5e-04 0.01 0.09 0.1 0.11 1.8e-01 3.0e-03 2.8e-03 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.00.30.6-0.1-0.2-0.0-0.1-0.10.10.10.10.0
Area under the delay curve2.22.34.0-2.01.82.0-1.71.90.5-0.6-1.3-1.31.3
BMI with tail0.41.22.7-1.51.71.4-1.11.21.40.70.10.1-0.6
BMI without tail0.10.20.4-0.60.60.6-0.60.60.4-0.0-0.2-0.20.1
Body weight1.14.68.8-2.52.92.9-3.02.82.20.7-0.8-0.8-0.4
Weight adjusted by age0.70.81.4-0.70.71.2-0.81.20.3-0.6-1.0-1.00.8
Bone surface0.40.61.80.60.70.9-1.31.10.90.70.20.2-0.6
Bone volume0.40.61.40.30.80.8-1.21.01.00.70.30.3-0.8
Breakpoint value in progressive ratio session0.70.71.7-1.20.90.3-0.20.40.51.31.21.2-0.1
Number of licking bursts0.20.20.4-0.6-0.2-0.0-0.3-0.1-0.5-0.5-0.5-0.50.7
Context. condit. distance diff. score4.25.18.62.0-2.2-2.92.3-2.7-1.01.72.82.8-1.2
Locomotion velocity, session 12.12.34.41.4-1.9-1.71.7-1.8-2.1-1.1-0.5-0.51.2
Locomotion distance, session 12.63.48.73.0-2.6-2.41.8-2.3-1.9-0.50.40.40.2
Locomotion velocity, session 20.10.10.30.2-0.2-0.10.5-0.4-0.2-0.5-0.5-0.50.2
Locomotion distance, session 20.10.11.11.0-0.2-0.1-0.1-0.10.20.1-0.0-0.0-0.4
Locomotion velocity, session 30.50.51.51.2-0.9-0.90.8-1.0-0.60.30.40.4-0.1
Locomotion distance, session 30.10.11.01.0-0.4-0.20.2-0.2-0.10.10.20.2-0.3
Stereotopy head waving bouts, day 30.70.81.30.1-0.9-0.80.8-1.0-1.1-1.0-0.9-0.91.0
Stereotopy head waving duration, day 30.10.10.3-0.6-0.1-0.30.2-0.4-0.2-0.3-0.4-0.40.2
Locomotion velocity, session 70.91.01.9-1.21.41.2-1.21.11.20.90.30.3-0.7
Locomotion distance, session 70.91.22.8-1.71.41.2-1.01.11.21.00.40.4-0.6
Stereotopy head waving bouts, day 70.10.20.40.6-0.30.00.4-0.20.1-0.6-0.5-0.5-0.3
Stereotopy head waving duration, day 70.30.30.70.10.40.8-0.30.50.5-0.7-0.8-0.8-0.2
Locomotion velocity, session 80.91.11.71.1-1.0-1.21.2-1.3-0.30.71.11.1-1.0
Locomotion distance, session 82.43.66.01.7-1.6-2.41.8-2.2-0.61.62.52.5-1.2
Degree of sensitization distance0.70.72.5-1.60.90.5-0.60.50.90.80.50.5-0.6
Degree of sensitization stereotypy0.20.20.90.50.20.40.30.10.70.20.10.1-0.9
Conditioned locomotion0.91.12.91.7-1.2-1.31.1-1.1-0.50.30.90.8-0.4
Cocaine response after cond. corrected1.31.53.7-0.71.20.7-0.50.51.61.71.11.1-1.9
Cocaine response after cond. not corrected1.41.64.2-0.51.30.9-0.50.71.71.71.11.0-2.1
Cocaine response before conditioning0.10.10.40.7-0.4-0.20.2-0.1-0.10.00.1-0.0-0.2
Saline control response1.31.73.6-1.91.40.7-0.60.71.21.91.61.5-0.5
Bone: connectivity density0.10.20.50.6-0.4-0.30.3-0.2-0.6-0.3-0.2-0.20.7
Bone: cortical apparent density0.30.41.00.9-0.8-0.50.7-0.3-1.0-0.5-0.1-0.10.6
Bone: cortical area1.62.54.2-1.01.91.9-2.02.02.01.30.50.5-1.4
Bone: cortical porosity0.00.00.3-0.1-0.1-0.1-0.1-0.10.20.20.20.2-0.5
Bone: cortical porosity0.20.20.90.2-0.1-0.1-0.2-0.00.40.50.50.5-0.9
Bone: cortical thickness0.81.31.9-0.51.31.2-1.41.41.41.30.70.7-1.3
Bone: cortical thickness1.01.13.2-0.30.50.1-0.20.30.91.81.71.7-1.2
Bone: cortical tissue density0.50.61.61.1-1.0-0.71.0-0.5-1.2-0.6-0.1-0.10.7
Condit. Reinf. active minus inactive responses0.50.61.3-0.00.51.0-0.70.90.3-0.7-1.2-1.20.1
Condit. Reinf. active-inactive response ratio1.01.02.1-0.61.01.4-1.01.30.4-0.7-1.3-1.30.4
Condit. Reinf. active responses0.10.20.60.8-0.5-0.40.4-0.4-0.1-0.10.00.0-0.3
Condit. Reinf. inactive responses2.83.46.11.9-1.9-2.51.9-2.3-0.81.12.12.1-1.0
Incentive salience index mean0.70.92.60.10.20.9-0.50.7-0.3-1.3-1.6-1.60.7
Condit. Reinf. lever presses0.20.20.60.1-0.3-0.10.2-0.2-0.6-0.8-0.6-0.60.6
Condit. Reinf. active minus inactive responses1.31.63.8-0.90.5-0.1-0.1-0.11.11.92.01.8-1.6
Condit. Reinf. active-inactive response ratio1.31.43.4-0.50.80.5-0.80.61.61.61.31.3-1.8
Condit. Reinf. active responses1.01.33.0-1.30.70.1-0.30.11.11.71.71.5-1.3
Condit. Reinf. inactive responses0.10.21.1-1.00.3-0.1-0.0-0.10.10.40.40.30.0
Condit. Reinf. lever presses0.40.61.8-0.4-0.0-0.50.4-0.40.41.11.31.2-0.7
Condit. Reinf. lever reinforcers received0.91.22.7-1.40.80.1-0.30.21.11.61.51.4-1.2
Conditioned reinforcement - actives0.10.10.20.3-0.2-0.10.3-0.10.1-0.5-0.3-0.3-0.3
Conditioned reinforcement - inactives1.01.23.2-0.50.10.4-0.00.2-0.6-1.7-1.7-1.81.3
Conditioned locomotion0.40.40.9-0.70.50.6-0.50.60.2-0.8-1.0-0.90.5
Patch foraging indifference point 0 sec0.40.61.70.20.00.4-0.40.4-0.5-1.2-1.3-1.31.0
Patch foraging indifference point AUC1.41.63.60.8-1.3-0.81.0-0.8-1.3-1.9-1.5-1.51.2
Delay disc. indifference point, 0s delay4.65.111.1-3.33.22.9-2.82.81.91.1-0.1-0.10.2
Delay disc. indifference point, 16s delay0.50.51.7-0.40.20.4-0.30.4-0.5-0.8-0.9-0.91.3
Delay disc. indifference point, 2s delay3.23.57.6-2.02.32.8-2.52.71.2-0.2-1.3-1.30.6
Delay disc. indifference point, 24s delay1.41.42.51.6-1.5-1.11.1-1.1-1.5-1.1-0.6-0.61.2
Delay disc. indifference point, 4s delay6.36.613.7-2.93.33.6-3.63.71.40.4-1.1-1.11.4
Delay disc. indifference point, 8s delay2.12.24.2-2.01.92.0-1.81.90.8-0.3-0.9-0.90.7
Indifference point function ln k0.20.30.80.10.30.2-0.40.20.30.90.80.7-0.3
Indifference point function log k0.20.30.80.10.30.2-0.40.20.30.90.80.7-0.3
Patch foraging total patch changes 0 sec0.30.51.10.4-0.4-0.10.0-0.1-0.7-1.1-1.0-1.00.9
Patch foraging total patch changes 12 sec1.21.64.00.3-1.0-0.60.8-0.8-1.4-2.0-1.6-1.61.3
Patch foraging total patch changes 18 sec1.31.64.20.6-1.2-0.70.7-0.8-1.3-2.1-1.7-1.61.2
Patch foraging total patch changes 24 sec0.30.31.60.5-0.0-0.1-0.10.00.70.60.40.5-1.3
Patch foraging total patch changes 6 sec0.91.33.4-0.4-0.10.3-0.20.2-0.8-1.8-1.8-1.71.5
Patch foraging time to switch 0 sec0.30.50.9-0.90.70.2-0.10.20.60.90.80.9-0.8
Patch foraging water rate 0 sec0.20.31.11.0-0.7-0.3-0.0-0.2-0.5-0.4-0.4-0.40.4
Patch foraging water rate 12 sec1.01.53.2-1.31.51.6-1.81.71.30.5-0.3-0.3-0.2
Patch foraging water rate 18 sec0.30.41.1-0.30.60.4-0.50.50.41.10.70.7-0.2
Patch foraging water rate 24 sec0.20.20.8-0.40.40.2-0.40.20.40.90.70.7-0.1
Patch foraging water rate 6 sec0.00.00.10.2-0.00.1-0.40.10.10.30.20.1-0.1
Seeking ratio, delayed vs. immediate footshock0.30.30.8-0.40.80.8-0.90.90.40.50.1-0.00.1
Distance traveled before self-admin1.61.73.1-1.51.71.8-1.51.71.60.5-0.3-0.1-0.7
Distance traveled after self-admin1.61.73.4-1.81.71.8-1.51.70.8-0.1-0.9-0.70.5
Extensor digitorum longus weight0.10.30.80.5-0.10.2-0.20.1-0.5-0.8-0.9-0.90.5
Bone: elastic displacement0.20.30.7-0.0-0.3-0.60.9-0.6-0.7-0.20.20.20.8
Bone: elastic work0.40.51.1-0.50.80.5-0.40.70.71.00.90.9-0.3
Bone: endosteal estimation0.81.64.2-1.11.61.4-1.31.32.11.00.40.4-1.4
Bone: endosteal perimeter0.51.12.9-1.01.31.0-0.91.01.70.90.50.5-1.3
Epididymis fat weight0.20.41.00.3-0.5-0.81.0-0.8-0.20.30.60.5-0.5
Delta time in closed arm before/after self-admin0.10.10.3-0.40.20.1-0.00.2-0.1-0.1-0.2-0.20.5
Delta time in open arm before/after self-admin0.50.41.0-0.60.70.8-1.00.90.4-0.2-0.6-0.60.3
Diff in mean of infusions in LGA sessions0.20.30.70.2-0.5-0.50.5-0.5-0.8-0.10.30.30.8
Delay discount exponential model param1.61.72.81.6-1.4-1.71.4-1.5-0.20.71.31.3-1.3
Extinction: sum of active levers before priming2.22.24.2-2.12.02.0-1.92.01.10.5-0.4-0.40.6
Active lever presses in extinction session 60.20.20.70.1-0.4-0.50.8-0.6-0.4-0.10.1-0.0-0.0
Bone: final force2.64.37.4-2.12.72.4-2.72.62.61.60.60.6-1.3
Bone: final moment2.84.57.6-2.22.72.5-2.72.62.71.60.60.6-1.4
Food consumed during 24 hour testing period0.10.10.7-0.1-0.10.0-0.10.1-0.5-0.3-0.0-0.20.8
Glucose0.20.30.6-0.30.60.6-0.70.60.1-0.4-0.8-0.80.6
Heart weight0.91.22.6-0.80.70.1-0.50.21.31.61.51.5-1.5
Delay discount hyperbolic model param2.62.75.22.1-2.0-2.32.0-2.1-0.70.51.31.3-1.2
Intermittent access intake day 1-15 change0.30.30.7-0.20.10.20.00.1-0.4-0.8-0.8-0.90.6
Intermittent access intake escalation0.20.20.4-0.60.40.4-0.10.2-0.1-0.4-0.5-0.60.3
Intermittent access intake escalation 20.10.10.3-0.30.0-0.10.3-0.2-0.4-0.2-0.2-0.20.5
Intermitt. access day 1 inactive lever presses0.20.21.11.0-0.6-0.40.2-0.2-0.60.10.30.20.3
Intermitt. access day 15 inactive lever presses0.20.30.60.2-0.6-0.80.7-0.8-0.40.00.40.4-0.1
Intermitt. access escalation Index0.30.31.01.0-0.7-0.40.5-0.6-0.0-0.2-0.0-0.2-0.5
Intermittent access day 1 total infusions0.20.20.8-0.70.40.1-0.20.10.70.30.20.3-0.9
Intermittent access day 15 total infusions0.40.51.9-1.40.80.6-0.40.40.6-0.4-0.7-0.7-0.3
Intermittent access terminal intake (last 3 days)0.50.52.0-1.40.90.7-0.50.50.8-0.2-0.5-0.4-0.4
Intermittent access total infusions0.40.51.8-1.30.80.6-0.40.40.8-0.4-0.7-0.6-0.4
Intermittent access day 1 locomotion0.20.20.5-0.50.2-0.2-0.0-0.10.50.60.70.7-0.7
Intermittent access day 15 total locomotion0.30.30.7-0.70.3-0.20.2-0.20.10.70.90.8-0.1
Intermittent access total locomotion0.10.10.7-0.90.50.2-0.30.20.20.20.10.20.1
Intermittent access standard deviation1.31.44.8-2.21.71.3-1.11.11.30.0-0.5-0.5-0.5
Left kidney weight0.61.73.1-1.11.51.3-1.51.21.81.40.80.7-1.2
Right kidney weight0.30.92.3-0.91.21.2-1.51.31.10.80.20.1-0.3
Cocaine induced anxiety1.41.62.5-1.41.31.6-1.41.40.3-0.8-1.4-1.50.9
Post-drug Anxiety0.20.20.6-0.4-0.2-0.20.5-0.4-0.6-0.5-0.3-0.40.8
Baseline Anxiety2.32.45.01.7-1.9-2.12.2-2.0-1.40.11.01.20.3
Tail length0.20.71.70.1-0.20.3-0.60.3-0.6-1.1-1.3-1.31.0
Length with tail0.72.77.4-1.61.92.2-2.72.31.10.1-1.1-1.20.2
Length without tail0.71.63.5-1.51.61.6-1.91.61.40.6-0.3-0.3-0.6
Times rat made contact with spout0.10.20.7-0.8-0.1-0.2-0.2-0.2-0.5-0.10.0-0.10.7
Lifetime Intake0.40.51.4-1.20.70.6-0.30.30.7-0.6-0.8-0.8-0.4
Liver weight, left1.93.06.1-1.52.01.6-1.61.62.51.71.01.0-2.3
Liver weight, right0.30.51.7-1.30.90.7-0.50.60.60.80.50.5-0.4
Locomotor activity0.91.43.20.9-1.1-0.50.6-0.7-1.4-1.8-1.6-1.51.3
Locomotor testing distance0.30.61.00.7-0.9-0.70.7-0.8-1.0-0.8-0.6-0.50.7
Locomotor testing rearing0.10.10.30.10.20.1-0.20.10.30.60.40.5-0.2
Locomotion in novel chamber3.03.67.4-2.12.42.7-2.32.61.2-0.3-1.5-1.50.6
Locomotion in novel chamber post-restriction2.02.43.90.01.31.3-2.01.61.92.01.31.3-1.9
Fecal boli incidents, locomotor time 10.30.40.80.0-0.5-0.40.9-0.6-0.7-0.8-0.5-0.40.9
Change in fecal boli incidents, locomotor task0.40.41.51.2-0.8-0.50.6-0.6-0.1-0.4-0.3-0.3-0.7
Time >=10cm from walls, locomotor time 10.20.20.5-0.10.40.5-0.70.50.70.3-0.00.0-0.4
Bouts of movement, locomotor time 10.10.10.1-0.30.20.3-0.40.20.2-0.2-0.3-0.3-0.1
Total resting periods, locomotor time 10.10.10.20.1-0.3-0.30.3-0.5-0.3-0.3-0.1-0.10.1
Rest time, locomotor task time 11.51.62.71.5-1.6-1.41.3-1.5-1.4-1.4-0.7-0.60.6
Distance moved, locomotor task time 13.53.86.1-2.22.52.1-2.42.32.22.11.00.9-0.9
Vertical activity count, locomotor time 13.43.56.9-2.62.62.3-2.42.32.01.30.20.1-0.6
Time >=10cm from walls, locomotor time 22.22.35.8-2.42.11.8-1.41.61.90.80.10.0-0.8
Bouts of movement, locomotor time 23.33.66.22.1-2.3-1.71.9-1.7-2.5-1.9-1.1-1.12.1
Total resting periods, locomotor time 24.54.88.22.5-2.7-2.22.3-2.2-2.9-2.1-1.1-1.12.1
Rest time, locomotor task time 22.83.24.92.2-2.2-1.71.8-1.9-2.2-2.0-1.2-1.11.2
Distance moved, locomotor task time 27.28.313.7-3.53.73.0-3.33.23.42.91.61.5-1.6
Vertical activity count, locomotor time 25.56.010.9-3.13.33.0-3.13.12.51.90.80.6-0.5
Light reinforcement 10.30.62.1-1.41.01.0-0.60.70.9-0.0-0.4-0.3-0.4
Light reinforcement 21.11.53.4-1.91.71.7-1.31.51.10.0-0.7-0.6-0.0
Bone: marrow area0.71.63.9-1.11.61.5-1.31.42.00.80.20.2-1.3
Bone: maximum diameter0.50.91.9-0.21.11.3-1.11.31.40.50.10.1-1.1
Bone: maximum force2.03.46.6-1.21.91.5-1.91.72.62.01.41.4-2.3
Bone: maximum moment2.13.67.1-1.32.01.6-1.91.82.72.11.41.4-2.3
Mean time between licks in bursts0.10.20.30.20.20.5-0.40.50.6-0.3-0.4-0.3-0.4
Mean num. licks in bursts0.10.10.30.5-0.2-0.30.5-0.3-0.10.10.30.30.1
Cd content in liver0.70.82.4-0.00.40.3-0.80.51.21.10.90.9-1.6
Co content in liver2.42.86.6-1.02.12.4-2.42.61.70.3-0.8-0.8-0.3
Cu content in liver0.40.51.91.4-0.9-0.70.9-0.7-0.4-0.30.10.1-0.4
Fe content in liver0.50.61.20.5-1.1-1.01.1-1.0-0.8-0.40.20.20.4
K content in liver0.30.31.1-0.40.3-0.00.4-0.20.80.60.50.5-1.0
Mg content in liver0.60.61.60.3-0.8-1.01.2-1.3-0.20.10.40.4-0.9
Mn content in liver0.40.40.80.6-0.6-0.40.6-0.5-0.7-0.9-0.8-0.80.4
Na content in liver0.30.31.10.2-0.6-0.61.1-0.9-0.5-0.20.20.2-0.0
Rb content in liver0.40.51.3-0.50.60.3-0.20.20.90.90.70.7-1.2
Se content in liver0.20.30.60.7-0.7-0.60.8-0.5-0.20.10.40.4-0.3
Sr content in liver0.40.30.9-0.60.30.4-0.10.3-0.5-0.6-0.7-0.71.0
Zn content in liver0.40.52.4-0.20.0-0.2-0.0-0.30.80.70.80.8-1.5
Bone: minimum diameter1.01.93.6-1.51.71.5-1.51.51.91.10.50.5-1.2
Time in familiar zone, hab. session 10.10.10.3-0.30.30.5-0.20.60.50.10.10.1-0.5
Time in novel zone, hab. session 10.10.10.20.00.1-0.20.1-0.2-0.20.30.30.30.4
Total zone transitions, hab. session 10.71.02.70.70.3-0.1-0.0-0.11.11.41.31.3-1.6
Total locomotion distance, hab. session 10.10.10.80.9-0.4-0.40.2-0.3-0.1-0.00.20.2-0.2
Locomotion velocity, hab. session 10.10.20.50.7-0.4-0.50.3-0.50.10.10.30.3-0.5
Time in familiar zone, hab. session 21.91.94.4-0.90.90.1-0.40.11.42.12.02.0-1.8
Time in novel zone, hab. session 20.80.81.80.3-0.10.5-0.40.6-0.4-1.2-1.4-1.41.1
Total zone transitions, hab. session 21.11.55.72.4-1.3-1.31.0-1.1-0.40.71.11.1-0.8
Total locomotion distance, hab. session 20.91.25.32.3-1.5-1.10.6-0.8-1.3-0.6-0.2-0.20.6
Locomotion velocity, hab. session 21.01.35.42.3-1.6-1.20.8-0.9-1.3-0.6-0.2-0.20.5
Novel to familiar place preference ratio0.30.40.7-0.80.80.8-0.60.70.6-0.1-0.4-0.40.2
Novelty place preference0.80.81.6-1.21.31.3-1.01.20.90.1-0.4-0.40.1
Time in novel zone, NPP test0.70.71.4-1.11.21.2-0.91.10.80.1-0.4-0.40.2
Total zone transitions, NPP test0.60.81.51.0-0.5-0.80.6-0.80.31.11.21.2-1.2
Total locomotion distance, NPP test0.71.02.21.5-1.4-1.41.1-1.4-0.9-0.20.20.2-0.2
Locomotion velocity, NPP test0.60.81.91.1-1.2-1.31.0-1.4-0.7-0.10.30.3-0.4
Intraocular pressure2.94.08.1-2.82.72.6-2.42.42.20.4-0.7-0.8-0.7
Delta distance traveled before/after self-admin0.91.03.4-0.0-0.30.00.1-0.0-1.3-1.3-1.3-1.21.8
Delta ambulatory time before/after self-admin0.80.92.90.1-0.5-0.30.3-0.3-1.4-1.2-1.1-0.91.7
Parametrial fat weight0.20.30.7-0.80.5-0.10.1-0.40.40.80.80.8-0.7
Pavlov. Cond. lever latency0.30.40.80.1-0.3-0.80.9-0.7-0.20.50.90.90.1
Pavlov. Cond. magazine entry latency0.50.61.40.8-0.6-0.20.1-0.1-1.0-1.2-1.0-1.00.9
Pavlov. Cond. change in total contacts0.40.40.80.80.10.7-0.50.70.2-0.7-0.9-0.9-0.4
Pavlov. Cond. index score0.60.82.10.7-0.30.4-0.40.3-0.6-1.3-1.4-1.40.7
Pavlov. Cond. latency score0.60.82.00.6-0.30.4-0.40.4-0.6-1.3-1.4-1.40.8
Pavlov. Cond. lever contacts0.40.51.00.10.40.9-0.90.90.2-0.7-1.0-1.00.2
Pavlov. Cond. magazine entry number2.63.27.0-1.61.40.4-0.70.52.12.62.32.3-2.1
Pavlov. Cond. intertrial magazine entries1.41.73.3-1.71.40.7-0.70.61.81.51.21.2-1.6
Pavlov. Cond. lever-magazine prob. diff.0.60.72.00.6-0.20.5-0.40.4-0.5-1.3-1.4-1.40.6
Pavlov. Cond. response bias1.92.35.40.9-0.70.30.10.2-1.4-2.3-2.3-2.31.7
Pavlov. Cond. lever latency0.10.20.80.9-0.3-0.2-0.40.1-0.00.40.40.6-0.3
Pavlov. Cond. magazine entry latency1.31.52.90.5-1.5-1.61.6-1.7-1.7-0.8-0.0-0.11.1
Pavlov. Cond. change in total contacts0.40.61.3-0.80.20.30.20.1-0.5-1.1-1.0-1.11.1
Pavlov. Cond. index score0.50.71.5-0.1-0.8-1.01.2-1.1-1.0-0.7-0.1-0.20.8
Pavlov. Cond. latency score0.91.12.10.2-1.2-1.21.4-1.4-1.4-0.9-0.3-0.41.1
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.1-0.20.6-0.3-0.2-0.2-0.0-0.20.1
Pavlov. Cond. magazine entry number0.50.61.40.10.80.8-0.91.01.20.80.30.4-1.0
Pavlov. Cond. intertrial magazine entries1.11.42.5-1.01.41.4-1.61.51.60.90.20.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.70.91.80.2-1.0-1.01.3-1.2-1.3-1.0-0.4-0.51.1
Pavlov. Cond. response bias0.10.10.5-0.6-0.1-0.30.7-0.5-0.1-0.00.20.1-0.1
Time in closed arm before self-admin0.10.10.30.3-0.4-0.30.1-0.3-0.3-0.5-0.4-0.40.3
Time in closed arm after self-admin0.50.51.30.4-0.7-0.70.6-0.6-1.0-0.8-0.6-0.51.2
Time in open arm before self-admin1.51.62.41.5-1.3-1.51.4-1.4-0.70.81.51.5-0.5
Time in open arm after self-admin0.20.20.7-0.40.30.1-0.30.30.40.80.70.8-0.2
Bone: periosteal estimation1.43.06.2-1.42.22.2-2.02.12.51.10.20.2-1.6
Bone: periosteal perimeter1.62.74.8-1.82.22.1-1.82.02.20.90.10.1-1.2
Bone: post-yield work0.91.34.80.20.40.2-0.20.21.51.41.31.3-2.2
Progressive ratio test 1 active lever presses0.40.41.0-0.40.40.7-0.60.70.3-0.8-1.0-1.00.1
Progressive ratio test 1 breakpoint0.60.61.0-0.70.81.0-0.91.00.6-0.6-0.9-0.9-0.0
Progressive ratio test 1 inactive lever presses0.30.30.4-0.40.60.4-0.60.60.60.60.50.4-0.3
Progressive ratio test 2 active lever presses0.10.10.2-0.30.40.4-0.30.30.4-0.2-0.3-0.2-0.2
Progressive ratio test 2 breakpoint0.10.20.4-0.30.40.4-0.30.40.4-0.4-0.6-0.5-0.1
Progressive ratio test 2 inactive lever presses0.40.51.2-0.70.30.4-0.00.2-0.2-1.1-1.1-1.10.8
Incentive Sensitization - Responses0.20.20.8-0.50.40.1-0.1-0.10.70.50.40.5-0.9
Incentive Sensitization - Breakpoint0.40.41.3-0.40.40.0-0.0-0.10.90.70.70.7-1.1
Sum of active levers in priming session hrs 5-61.41.43.60.7-0.6-1.00.9-0.90.21.51.91.8-0.9
Progressive ratio1.41.62.6-1.11.11.6-1.41.60.4-1.0-1.6-1.50.8
Food seeking constrained by brief footshock2.32.95.0-2.21.92.2-1.71.91.0-0.9-1.8-1.80.7
Seeking ratio, punishment vs. effort0.40.50.90.3-0.4-0.80.9-0.8-0.10.70.90.9-0.4
Retroperitoneal fat weight0.62.04.6-1.41.00.00.2-0.11.42.12.01.9-1.6
Reaction time number correct0.30.51.5-0.50.50.3-0.80.60.01.21.01.00.5
Reaction time mean minus median0.71.02.21.0-0.9-0.50.9-0.6-1.0-1.5-1.2-1.20.8
Reaction time mean minus median AUC0.50.71.31.1-1.0-0.70.9-0.6-1.0-0.9-0.5-0.60.5
Reaction time num false alarms0.81.12.51.6-1.1-0.60.6-0.4-1.2-1.3-1.0-0.91.3
Reaction time num false alarms AUC1.21.73.71.9-1.3-0.60.6-0.5-1.5-1.6-1.3-1.31.6
Reaction time trials correct on left0.30.51.5-0.50.50.3-0.80.60.01.21.01.00.5
Reaction time trials on left0.30.51.5-0.30.50.2-0.70.50.01.21.01.00.4
Reaction time mean0.30.51.10.9-0.8-0.50.7-0.6-0.4-1.0-0.7-0.8-0.1
Reaction time mean AUC0.30.51.00.9-0.8-0.40.7-0.5-0.5-1.0-0.7-0.80.0
Median of all reaction times0.20.20.50.6-0.6-0.40.5-0.5-0.2-0.7-0.4-0.5-0.3
Reaction time omissions0.30.42.61.6-0.5-0.30.4-0.20.2-0.10.0-0.0-0.9
Reaction time false alarm rate1.52.14.32.1-1.6-1.01.2-1.0-1.4-1.9-1.4-1.41.0
Reaction time premature initiation rate1.72.36.0-0.50.7-0.1-0.20.01.62.42.32.2-1.9
Reaction time premature initiations2.43.39.8-0.71.00.1-0.60.41.73.12.82.8-1.7
Std. dev. reaction times1.11.53.11.6-1.4-0.81.0-0.8-1.2-1.8-1.3-1.40.7
Reaction time trials completed0.30.51.5-0.30.50.2-0.70.50.01.21.01.00.4
Reaction time trials AUC0.30.41.2-0.30.40.1-0.60.4-0.01.10.90.90.5
Run reversals in cocaine runway, females1.61.63.9-2.01.61.1-1.21.11.21.30.91.0-0.7
Run reversals in cocaine runway, males0.10.10.20.10.00.3-0.30.3-0.2-0.3-0.4-0.40.4
Latency to leave start box in cocaine runway1.11.21.71.3-1.0-1.31.0-1.2-0.10.81.31.2-1.1
Latency to leave start box in cocaine runway, F0.40.40.70.7-0.7-0.90.7-0.8-0.10.50.80.6-0.7
Latency to leave start box in cocaine runway, M0.40.40.70.9-0.6-0.70.7-0.7-0.20.30.60.6-0.5
Std. dev. time between licks in bursts0.50.61.8-0.20.61.0-1.31.30.6-0.3-0.7-0.6-0.0
Total sessions with >9 infusions0.30.30.7-0.2-0.4-0.50.7-0.5-0.6-0.8-0.6-0.60.6
Short access day 1 total inactive lever presses0.60.71.7-1.00.20.20.10.0-0.5-1.2-1.2-1.31.1
Short access day 10 total inactive lever presses0.20.20.50.7-0.5-0.50.5-0.4-0.50.20.40.20.3
Short access day 1 total infusions0.40.41.1-0.4-0.4-0.50.8-0.8-0.4-1.1-0.7-0.70.1
Short access day 10 total infusions0.60.61.0-1.00.80.9-0.70.71.0-0.5-0.8-0.8-0.6
Short access total infusions0.40.41.2-0.80.20.30.10.00.2-1.0-1.1-1.1-0.0
Short access day 1 locomotion0.91.02.6-0.90.20.4-0.00.2-0.3-1.6-1.6-1.60.9
Short access day 10 total locomotion0.50.51.9-0.2-0.3-0.20.4-0.5-0.4-1.4-1.1-1.20.3
Short access total locomotion0.70.72.4-0.4-0.4-0.40.6-0.6-0.5-1.6-1.3-1.30.5
One hour access (0.3 mA shock)0.40.50.8-0.90.70.8-0.50.50.7-0.6-0.8-0.8-0.3
Compulsive drug intake0.50.51.10.6-0.9-1.10.9-1.0-0.70.20.60.60.2
One hour access (shock baseline)1.51.73.2-1.81.71.7-1.41.51.3-0.4-1.1-1.0-0.2
Social response proportion1.92.15.80.7-0.8-0.20.5-0.2-1.8-2.0-1.8-1.82.4
Social responses2.02.66.50.0-0.20.7-0.40.5-1.2-2.3-2.5-2.52.3
Social time1.72.34.71.3-1.5-1.01.5-1.1-1.7-2.2-1.6-1.61.4
Soleus weight0.30.92.60.9-0.5-0.80.8-0.90.50.91.11.1-1.6
Bone: stiffness1.62.44.8-1.21.71.6-2.11.72.21.20.50.5-1.9
Tibialis anterior weight0.20.61.80.50.10.6-0.80.6-0.3-1.0-1.3-1.30.5
Time to tail flick, vehicle, before self-admin0.91.02.11.2-1.2-1.41.5-1.4-0.7-0.10.30.3-0.2
Time to tail flick, vehicle, after self-admin0.20.20.4-0.60.1-0.00.3-0.2-0.5-0.6-0.5-0.50.7
Time to tail flick, test, before self-admin1.91.85.9-2.41.91.8-1.51.50.60.0-0.6-0.50.8
Time to tail flick, test, after self-admin1.11.11.91.2-1.0-1.11.2-1.2-0.60.71.41.3-0.5
Delta time to tail flick, vehicle, before/after SA0.90.92.0-0.50.30.7-0.50.6-0.6-1.3-1.4-1.41.3
Delta time to tail flick, test, before/after SA3.12.87.22.7-2.1-2.01.8-1.8-0.90.51.31.3-1.0
Tibia length5.615.927.8-4.34.94.7-5.04.75.32.70.60.6-3.3
Ambulatory time before self-admin2.52.64.7-1.72.12.2-2.02.12.00.5-0.4-0.4-0.9
Ambulatory time after self-admin1.71.93.9-2.01.91.9-1.71.80.80.1-0.8-0.50.5
Bone: tissue strength0.40.40.8-0.60.70.6-0.60.60.90.50.20.2-0.7
Total heroin consumption0.40.51.4-0.30.40.2-0.20.40.61.21.11.0-0.5
Bone: trabecular number0.00.10.20.4-0.2-0.10.1-0.0-0.3-0.3-0.3-0.30.4
Bone: trabecular spacing0.10.21.4-1.20.0-0.10.5-0.30.1-0.2-0.1-0.1-0.2
Bone: trabecular thickness0.70.81.60.11.00.9-1.31.11.01.20.70.7-0.4
Bone: trabecular tissue density0.50.84.22.0-0.8-0.60.0-0.20.10.40.60.6-1.2
Water consumed over 24 hours0.50.61.3-1.10.60.9-1.00.9-0.1-0.1-0.4-0.50.8
Number of responses in last shaping day1.71.83.60.9-1.4-1.11.5-1.2-1.3-1.9-1.3-1.41.0