Hub : Genes

Fzd5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Fzd5	0.18	0.15	3.0e-03	0.05	0.06	0.01	0.05	2.2e-02	1.4e-02	1.9e-01	2.4e-02
2	PL	gene expression	Fzd5	0.05	0.04	1.1e-06	0.03	0.05	0.03	0.04	1.2e-04	7.0e-06	1.4e-04	6.6e-05
3	NAcc	gene expression	Fzd5	0.03	0.02	6.3e-04	0.02	0.02	0.01	0.02	1.1e-03	1.5e-03	1.9e-03	1.0e-03
4	Liver	gene expression	Fzd5	0.04	0.04	1.4e-04	0.02	0.02	0.02	0.02	1.0e-03	2.1e-03	3.8e-03	2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.2	0.3	0.4	0.4	-0.4
Area under the delay curve	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.3
BMI with tail	8.2	28.1	30.8	-5.5	-5.4	-5.2	5.1
BMI without tail	3.0	9.1	9.6	-3.1	-3.1	-3.0	2.9
Body weight	0.2	0.8	1.0	-1.0	-0.9	-0.9	0.8
Weight adjusted by age	0.8	1.2	1.8	0.8	1.0	1.3	-1.3
Bone surface	0.4	0.7	0.9	0.6	0.7	0.9	-0.9
Bone volume	0.9	1.6	1.7	1.2	1.2	1.3	-1.3
Breakpoint value in progressive ratio session	2.5	3.0	3.4	1.6	1.6	1.9	-1.8
Number of licking bursts	0.2	0.3	0.5	-0.4	-0.5	-0.7	0.7
Context. condit. distance diff. score	1.1	1.3	1.6	-1.0	-1.1	-1.3	1.2
Locomotion velocity, session 1	1.3	1.4	1.7	1.3	1.3	1.2	-1.1
Locomotion distance, session 1	0.1	0.1	0.1	0.3	0.3	0.4	-0.2
Locomotion velocity, session 2	0.1	0.1	0.2	0.1	0.2	0.4	-0.3
Locomotion distance, session 2	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.3
Locomotion velocity, session 3	0.6	0.7	0.8	-0.9	-0.8	-0.8	0.9
Locomotion distance, session 3	1.6	1.7	1.8	1.3	1.3	1.3	-1.3
Stereotopy head waving bouts, day 3	2.2	2.6	2.8	-1.7	-1.7	-1.5	1.6
Stereotopy head waving duration, day 3	2.4	2.9	3.3	-1.8	-1.7	-1.6	1.6
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1
Locomotion distance, session 7	0.5	0.6	0.8	0.7	0.8	0.9	-0.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	-0.5	-0.5	-0.6	0.6
Stereotopy head waving duration, day 7	2.5	3.0	3.2	-1.7	-1.7	-1.7	1.8
Locomotion velocity, session 8	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4
Locomotion distance, session 8	0.3	0.4	0.6	-0.5	-0.6	-0.7	0.8
Degree of sensitization distance	0.3	0.3	0.4	-0.6	-0.6	-0.5	0.5
Degree of sensitization stereotypy	0.8	0.9	1.0	-0.9	-0.9	-1.0	1.0
Conditioned locomotion	1.3	1.5	1.7	1.2	1.2	1.2	-1.3
Cocaine response after cond. corrected	1.2	1.4	1.6	1.2	1.2	1.2	-1.3
Cocaine response after cond. not corrected	1.4	1.7	1.9	1.4	1.4	1.2	-1.3
Cocaine response before conditioning	0.1	0.1	0.2	0.1	-0.1	-0.3	0.4
Saline control response	0.2	0.3	0.5	-0.7	-0.7	-0.4	0.4
Bone: connectivity density	0.5	0.8	1.0	-1.0	-1.0	-0.8	0.8
Bone: cortical apparent density	1.3	1.8	2.3	-1.5	-1.4	-1.2	1.2
Bone: cortical area	0.8	1.2	1.3	1.0	1.0	1.2	-1.1
Bone: cortical porosity	7.7	8.3	9.5	3.1	3.0	2.7	-2.7
Bone: cortical porosity	9.1	9.9	11.3	3.4	3.3	3.0	-2.9
Bone: cortical thickness	0.2	0.4	0.5	0.5	0.6	0.7	-0.7
Bone: cortical thickness	1.4	1.7	1.9	1.2	1.3	1.4	-1.3
Bone: cortical tissue density	1.6	2.2	2.7	-1.6	-1.6	-1.3	1.3
Condit. Reinf. active minus inactive responses	1.1	1.3	1.4	1.2	1.2	1.1	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.3	0.2	-0.2
Condit. Reinf. active responses	2.0	2.5	2.8	1.5	1.5	1.7	-1.5
Condit. Reinf. inactive responses	1.5	1.8	2.3	1.2	1.3	1.5	-1.4
Incentive salience index mean	1.6	1.9	2.2	1.3	1.4	1.5	-1.4
Condit. Reinf. lever presses	1.1	1.6	2.1	1.1	1.2	1.4	-1.3
Condit. Reinf. active minus inactive responses	8.1	10.4	10.6	3.2	3.2	3.2	-3.2
Condit. Reinf. active-inactive response ratio	6.5	7.5	8.0	2.8	2.8	2.7	-2.7
Condit. Reinf. active responses	5.7	7.9	8.2	2.7	2.8	2.8	-2.9
Condit. Reinf. inactive responses	0.3	0.5	0.6	0.6	0.6	0.7	-0.7
Condit. Reinf. lever presses	1.3	1.8	1.8	1.3	1.3	1.3	-1.4
Condit. Reinf. lever reinforcers received	5.8	8.1	8.3	2.8	2.9	2.9	-2.9
Conditioned reinforcement - actives	1.0	1.7	1.9	-1.4	-1.3	-1.2	1.2
Conditioned reinforcement - inactives	1.6	2.4	2.7	1.4	1.5	1.6	-1.6
Conditioned locomotion	4.9	6.4	8.3	-2.9	-2.7	-2.2	2.3
Patch foraging indifference point 0 sec	0.9	1.6	1.9	-1.2	-1.2	-1.4	1.3
Patch foraging indifference point AUC	1.4	2.0	2.6	1.1	1.2	1.6	-1.6
Delay disc. indifference point, 0s delay	1.5	1.6	1.9	-1.4	-1.4	-1.2	1.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 2s delay	1.7	1.9	2.0	-1.4	-1.4	-1.3	1.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.3
Delay disc. indifference point, 4s delay	1.3	1.4	1.6	-1.3	-1.2	-1.1	1.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.1	0.1	-0.2
Indifference point function ln k	2.2	3.8	4.6	-1.7	-1.8	-2.1	2.1
Indifference point function log k	2.2	3.8	4.6	-1.7	-1.8	-2.1	2.1
Patch foraging total patch changes 0 sec	0.8	1.5	1.8	-1.1	-1.1	-1.3	1.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	0.4	0.5	0.8	-0.7
Patch foraging total patch changes 18 sec	0.2	0.3	0.4	-0.7	-0.6	-0.6	0.5
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	0.2	0.3	0.5	-0.5
Patch foraging total patch changes 6 sec	0.6	1.0	1.3	-1.1	-1.1	-0.9	0.8
Patch foraging time to switch 0 sec	0.0	0.0	0.0	0.1	0.1	-0.0	0.0
Patch foraging water rate 0 sec	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.3
Patch foraging water rate 12 sec	0.4	0.9	1.3	-0.8	-0.8	-1.1	1.1
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.7	0.6	0.2	-0.2
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.1	-0.3	-0.9	0.8
Patch foraging water rate 6 sec	1.9	2.8	3.0	-1.6	-1.6	-1.7	1.7
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.4	0.9	1.0	1.2	-1.2
Distance traveled before self-admin	3.3	4.4	5.0	1.9	2.0	2.2	-2.2
Distance traveled after self-admin	0.1	0.1	0.2	0.1	0.2	0.4	-0.4
Extensor digitorum longus weight	1.9	7.6	8.7	-3.0	-2.9	-2.6	2.6
Bone: elastic displacement	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.2
Bone: elastic work	0.4	0.5	0.5	0.7	0.7	0.7	-0.7
Bone: endosteal estimation	1.8	3.9	4.1	1.9	1.9	2.0	-2.0
Bone: endosteal perimeter	0.3	0.7	0.9	1.0	0.9	0.8	-0.7
Epididymis fat weight	0.2	0.6	0.6	-0.7	-0.8	-0.7	0.7
Delta time in closed arm before/after self-admin	1.0	1.0	1.1	-1.0	-1.0	-1.0	0.9
Delta time in open arm before/after self-admin	5.8	5.7	5.8	2.4	2.4	2.4	-2.4
Diff in mean of infusions in LGA sessions	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.4	0.3	-0.2
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	-0.2	0.1	0.0
Active lever presses in extinction session 6	0.9	0.9	0.9	0.9	0.9	0.9	-0.9
Bone: final force	1.6	2.5	2.8	1.7	1.6	1.5	-1.5
Bone: final moment	1.0	1.6	1.9	1.4	1.3	1.2	-1.2
Food consumed during 24 hour testing period	0.7	0.9	1.0	0.9	0.9	1.0	-1.0
Glucose	0.7	1.1	1.1	-1.0	-1.0	-1.0	1.0
Heart weight	0.1	0.2	0.4	0.6	0.5	0.2	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	0.5	0.4	-0.4
Intermittent access intake day 1-15 change	0.2	0.5	0.5	-0.7	-0.7	-0.7	0.7
Intermittent access intake escalation	0.2	0.5	0.6	-0.5	-0.6	-0.8	0.8
Intermittent access intake escalation 2	0.3	0.3	0.4	-0.5	-0.6	-0.6	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	-0.4	-0.5	-0.7	0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.4	0.3	0.2	-0.2
Intermitt. access escalation Index	0.2	0.3	0.5	-0.7	-0.6	-0.3	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.2	0.3	0.5	-0.5
Intermittent access day 15 total infusions	0.5	0.7	0.8	-0.9	-0.8	-0.8	0.8
Intermittent access terminal intake (last 3 days)	1.3	1.8	1.8	-1.3	-1.3	-1.3	1.3
Intermittent access total infusions	0.2	0.3	0.5	-0.7	-0.6	-0.4	0.4
Intermittent access day 1 locomotion	0.0	0.1	0.2	-0.4	-0.3	0.0	0.0
Intermittent access day 15 total locomotion	0.6	1.0	1.5	-1.2	-1.1	-0.8	0.9
Intermittent access total locomotion	2.4	2.9	4.1	-2.0	-1.8	-1.4	1.4
Intermittent access standard deviation	0.0	0.0	0.1	0.3	0.2	0.1	-0.1
Left kidney weight	0.5	2.4	2.9	-1.7	-1.6	-1.5	1.3
Right kidney weight	0.8	3.4	3.5	-1.9	-1.8	-1.9	1.8
Cocaine induced anxiety	0.3	0.4	0.6	-0.5	-0.6	-0.8	0.7
Post-drug Anxiety	1.2	1.3	1.5	-1.1	-1.1	-1.2	1.2
Baseline Anxiety	0.2	0.3	0.3	-0.5	-0.5	-0.5	0.5
Tail length	3.4	13.4	14.0	3.7	3.7	3.5	-3.6
Length with tail	3.9	17.0	17.6	4.2	4.2	4.0	-4.1
Length without tail	0.7	2.3	2.4	1.6	1.6	1.5	-1.5
Times rat made contact with spout	0.8	1.0	1.0	1.0	1.0	1.0	-0.9
Lifetime Intake	0.5	0.7	0.8	-0.9	-0.8	-0.8	0.8
Liver weight, left	3.1	5.1	5.9	2.0	2.2	2.4	-2.4
Liver weight, right	0.2	0.3	0.4	-0.6	-0.6	-0.5	0.5
Locomotor activity	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.3
Locomotor testing distance	0.1	0.3	0.4	-0.2	-0.3	-0.7	0.7
Locomotor testing rearing	0.1	0.1	0.2	-0.0	-0.2	-0.5	0.5
Locomotion in novel chamber	0.5	0.7	1.2	-1.1	-1.0	-0.5	0.6
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1
Fecal boli incidents, locomotor time 1	1.0	1.5	1.6	1.3	1.3	1.2	-1.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	0.1	0.1	-0.1
Time >=10cm from walls, locomotor time 1	2.5	2.7	2.8	1.6	1.6	1.6	-1.7
Bouts of movement, locomotor time 1	1.8	2.1	2.1	1.4	1.4	1.4	-1.5
Total resting periods, locomotor time 1	1.2	1.4	1.4	1.2	1.2	1.1	-1.2
Rest time, locomotor task time 1	2.6	3.2	3.3	1.8	1.8	1.8	-1.8
Distance moved, locomotor task time 1	0.4	0.6	0.9	-0.9	-0.9	-0.7	0.7
Vertical activity count, locomotor time 1	0.5	1.2	1.4	-1.2	-1.2	-1.0	1.1
Time >=10cm from walls, locomotor time 2	0.6	0.9	0.9	1.0	1.0	0.9	-0.9
Bouts of movement, locomotor time 2	0.4	0.6	0.6	-0.8	-0.8	-0.8	0.8
Total resting periods, locomotor time 2	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3
Rest time, locomotor task time 2	1.6	2.1	2.2	1.5	1.5	1.4	-1.4
Distance moved, locomotor task time 2	0.8	1.0	1.2	-1.1	-1.1	-0.9	0.9
Vertical activity count, locomotor time 2	3.4	4.6	4.9	-2.2	-2.2	-2.1	2.1
Light reinforcement 1	1.2	2.9	3.1	-1.8	-1.7	-1.7	1.7
Light reinforcement 2	0.6	0.9	1.0	1.0	0.9	1.0	-1.0
Bone: marrow area	1.6	3.5	3.8	1.8	1.8	1.9	-1.9
Bone: maximum diameter	0.9	1.7	1.7	1.3	1.3	1.3	-1.3
Bone: maximum force	1.0	1.7	1.8	1.4	1.3	1.3	-1.3
Bone: maximum moment	0.4	0.8	0.9	1.0	0.9	0.8	-0.8
Mean time between licks in bursts	0.4	1.0	1.0	-1.0	-1.0	-1.0	1.0
Mean num. licks in bursts	0.4	0.7	0.8	0.7	0.7	0.9	-0.9
Cd content in liver	1.0	1.2	1.5	-0.9	-1.0	-1.2	1.2
Co content in liver	0.0	0.0	0.0	0.1	0.0	-0.1	0.1
Cu content in liver	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.4
Fe content in liver	0.2	0.2	0.3	0.6	0.5	0.3	-0.3
K content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.0	-0.0
Mg content in liver	0.2	0.2	0.4	-0.6	-0.5	-0.3	0.3
Mn content in liver	1.4	1.5	1.6	-1.3	-1.3	-1.2	1.2
Na content in liver	0.9	1.0	1.6	0.6	0.8	1.3	-1.2
Rb content in liver	0.2	0.2	0.2	-0.5	-0.5	-0.4	0.4
Se content in liver	0.3	0.3	0.5	-0.4	-0.5	-0.7	0.7
Sr content in liver	1.0	0.9	0.9	0.9	0.9	0.9	-1.0
Zn content in liver	0.2	0.3	0.3	-0.6	-0.5	-0.4	0.5
Bone: minimum diameter	1.6	2.8	2.9	1.7	1.7	1.7	-1.6
Time in familiar zone, hab. session 1	2.2	2.1	2.3	-1.5	-1.5	-1.5	1.3
Time in novel zone, hab. session 1	6.4	6.4	6.9	2.6	2.6	2.5	-2.4
Total zone transitions, hab. session 1	0.6	0.8	0.9	1.0	1.0	0.9	-0.8
Total locomotion distance, hab. session 1	1.9	2.8	3.0	1.7	1.7	1.6	-1.6
Locomotion velocity, hab. session 1	1.5	2.1	2.3	1.5	1.5	1.4	-1.4
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.5	-0.5	-0.3	0.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.3	0.2	-0.1	0.2
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.3	0.2	-0.0	0.2
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.3	0.3	0.0	0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.3	0.2	0.0	0.1
Novel to familiar place preference ratio	1.3	1.5	1.5	1.2	1.2	1.1	-1.2
Novelty place preference	1.8	1.9	2.2	1.3	1.4	1.4	-1.5
Time in novel zone, NPP test	2.0	2.2	2.4	1.4	1.5	1.4	-1.6
Total zone transitions, NPP test	0.2	0.3	0.3	0.5	0.6	0.6	-0.4
Total locomotion distance, NPP test	0.5	0.7	0.8	0.9	0.9	0.9	-0.7
Locomotion velocity, NPP test	0.2	0.3	0.3	0.5	0.6	0.6	-0.4
Intraocular pressure	3.4	4.9	5.3	-2.1	-2.2	-2.2	2.3
Delta distance traveled before/after self-admin	2.0	2.1	2.2	-1.5	-1.5	-1.4	1.5
Delta ambulatory time before/after self-admin	2.0	2.5	2.5	-1.6	-1.6	-1.5	1.6
Parametrial fat weight	0.1	0.1	0.4	-0.0	-0.2	-0.6	0.4
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.4	-0.4	-0.5	0.4
Pavlov. Cond. magazine entry latency	0.9	1.2	1.3	1.1	1.1	1.1	-1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.1
Pavlov. Cond. index score	0.6	0.8	1.0	0.8	0.8	1.0	-0.9
Pavlov. Cond. latency score	0.6	0.7	0.9	0.8	0.8	0.9	-0.8
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.3	0.4	0.6	-0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.0	0.0	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	0.8	0.8	1.0	-0.9
Pavlov. Cond. response bias	0.6	0.7	0.8	0.9	0.9	0.9	-0.8
Pavlov. Cond. lever latency	1.3	1.8	2.1	-1.4	-1.4	-1.3	1.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.4	0.5	0.5	0.6	-0.6
Pavlov. Cond. change in total contacts	1.5	2.3	2.4	1.6	1.5	1.5	-1.5
Pavlov. Cond. index score	1.9	2.6	2.6	1.6	1.6	1.6	-1.6
Pavlov. Cond. latency score	1.7	2.2	2.3	1.5	1.5	1.5	-1.5
Pavlov. Cond. lever contacts	2.2	3.0	3.3	1.8	1.8	1.7	-1.7
Pavlov. Cond. magazine entry number	0.9	1.1	1.3	-0.9	-1.0	-1.1	1.1
Pavlov. Cond. intertrial magazine entries	1.9	2.8	2.9	-1.7	-1.7	-1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.4	2.4	1.5	1.5	1.5	-1.5
Pavlov. Cond. response bias	2.3	3.1	3.2	1.8	1.8	1.7	-1.7
Time in closed arm before self-admin	1.4	1.8	1.9	1.4	1.3	1.3	-1.2
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.1	-0.0	0.1
Time in open arm before self-admin	2.6	2.8	3.0	-1.7	-1.7	-1.7	1.6
Time in open arm after self-admin	2.6	2.9	3.3	1.5	1.6	1.8	-1.8
Bone: periosteal estimation	1.7	3.6	3.7	1.9	1.9	1.9	-1.9
Bone: periosteal perimeter	1.1	1.9	2.0	1.4	1.4	1.4	-1.3
Bone: post-yield work	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.2
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.0
Progressive ratio test 1 inactive lever presses	1.3	1.8	1.9	-1.4	-1.4	-1.3	1.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.0	0.1	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.7	-0.8	-0.6	-0.2	0.2
Incentive Sensitization - Responses	0.1	0.2	0.3	0.2	0.3	0.6	-0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.1	0.2	0.4	-0.5
Sum of active levers in priming session hrs 5-6	2.2	2.1	2.6	1.2	1.3	1.6	-1.5
Progressive ratio	0.0	0.0	0.1	0.3	0.2	0.1	-0.2
Food seeking constrained by brief footshock	1.5	1.9	2.4	-1.6	-1.5	-1.2	1.3
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	-1.1	-1.0	-0.7	0.8
Retroperitoneal fat weight	0.8	3.3	3.7	-1.8	-1.8	-1.9	1.7
Reaction time number correct	0.4	0.9	1.2	-0.7	-0.8	-1.1	1.1
Reaction time mean minus median	0.0	0.0	0.1	-0.0	0.1	0.3	-0.3
Reaction time mean minus median AUC	0.1	0.2	0.3	0.4	0.4	0.5	-0.6
Reaction time num false alarms	3.9	5.5	5.5	-2.3	-2.3	-2.3	2.3
Reaction time num false alarms AUC	3.3	5.1	5.3	-2.2	-2.2	-2.3	2.3
Reaction time trials correct on left	0.4	0.9	1.2	-0.7	-0.8	-1.1	1.1
Reaction time trials on left	0.5	0.9	1.2	-0.7	-0.8	-1.1	1.1
Reaction time mean	3.5	5.5	5.8	2.3	2.3	2.4	-2.4
Reaction time mean AUC	2.6	4.2	4.5	2.0	2.0	2.1	-2.1
Median of all reaction times	5.5	7.8	8.0	2.8	2.8	2.8	-2.8
Reaction time omissions	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4
Reaction time false alarm rate	1.6	2.2	2.3	-1.5	-1.5	-1.5	1.5
Reaction time premature initiation rate	0.2	0.3	0.3	0.5	0.5	0.5	-0.5
Reaction time premature initiations	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1
Std. dev. reaction times	0.5	1.0	1.2	0.9	0.9	1.1	-1.1
Reaction time trials completed	0.5	0.9	1.2	-0.7	-0.8	-1.1	1.1
Reaction time trials AUC	0.3	0.6	0.9	-0.6	-0.7	-0.9	0.9
Run reversals in cocaine runway, females	0.5	0.5	0.8	-0.6	-0.6	-0.9	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.6	0.5	0.3	-0.3
Latency to leave start box in cocaine runway	2.8	3.2	3.3	-1.8	-1.8	-1.8	1.7
Latency to leave start box in cocaine runway, F	2.6	2.9	3.2	-1.6	-1.7	-1.8	1.7
Latency to leave start box in cocaine runway, M	0.6	0.6	0.8	-0.9	-0.8	-0.6	0.6
Std. dev. time between licks in bursts	2.9	4.0	4.2	-2.0	-1.9	-2.0	2.0
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.1
Short access day 1 total inactive lever presses	0.5	0.7	1.0	-1.0	-0.9	-0.7	0.7
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.5	0.4	0.1	-0.1
Short access day 1 total infusions	0.3	0.3	0.4	-0.5	-0.5	-0.7	0.6
Short access day 10 total infusions	0.2	0.2	0.3	-0.6	-0.5	-0.4	0.4
Short access total infusions	1.0	1.3	1.5	-1.0	-1.1	-1.2	1.2
Short access day 1 locomotion	0.3	0.4	0.4	0.6	0.6	0.6	-0.6
Short access day 10 total locomotion	0.3	0.5	0.5	-0.7	-0.7	-0.7	0.7
Short access total locomotion	0.9	1.1	1.4	-1.2	-1.1	-0.9	1.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.5	-0.3	-0.0	0.1
Compulsive drug intake	0.2	0.2	0.4	-0.2	-0.3	-0.6	0.6
One hour access (shock baseline)	0.1	0.1	0.2	-0.5	-0.4	-0.2	0.3
Social response proportion	0.4	0.4	0.5	0.6	0.6	0.7	-0.7
Social responses	0.7	0.9	1.0	0.9	0.9	1.0	-1.0
Social time	0.3	0.4	0.5	0.6	0.6	0.7	-0.7
Soleus weight	0.0	0.1	0.2	-0.4	-0.3	0.0	-0.1
Bone: stiffness	0.8	1.3	1.4	1.2	1.2	1.1	-1.1
Tibialis anterior weight	0.4	1.2	1.6	-1.3	-1.2	-0.9	0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	0.3	0.4	0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.4	0.6	0.9	1.0	0.8	0.5	-0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.6	0.5	0.2	-0.2
Time to tail flick, test, after self-admin	2.6	2.7	3.2	-1.8	-1.7	-1.5	1.5
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.0	-0.2	-0.4	0.4
Delta time to tail flick, test, before/after SA	1.8	1.8	2.7	-1.6	-1.5	-1.1	1.1
Tibia length	1.5	4.1	4.3	2.1	2.0	2.0	-2.0
Ambulatory time before self-admin	1.9	2.9	3.5	1.4	1.6	1.9	-1.8
Ambulatory time after self-admin	0.2	0.3	0.6	-0.7	-0.6	-0.3	0.3
Bone: tissue strength	0.6	0.6	0.8	-0.6	-0.7	-0.9	0.8
Total heroin consumption	0.8	0.9	1.0	1.0	1.0	1.0	-0.9
Bone: trabecular number	0.1	0.2	0.3	-0.5	-0.5	-0.4	0.4
Bone: trabecular spacing	0.4	0.5	0.6	0.8	0.7	0.6	-0.7
Bone: trabecular thickness	0.5	0.7	0.7	0.8	0.8	0.8	-0.8
Bone: trabecular tissue density	0.9	1.4	1.6	1.3	1.2	1.1	-1.1
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0
Number of responses in last shaping day	0.5	0.5	0.6	0.8	0.8	0.7	-0.7