Hub : Genes

Fsip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS XM_039104542.2 0.03 0.02 2.6e-03 0 0 0.01 0.01 1.3e-01 1.1e-01 9.1e-03 4.1e-02
2 NAcc alternative TSS XM_039104543.2 0.03 0.02 1.2e-03 0 0.01 0.01 0.01 4.6e-02 1.4e-02 2.2e-03 1.0e-02
3 pVTA gene expression Fsip1 0.41 0.1 0.0e+00 0.31 0.34 0.36 0.37 3.8e-25 1.5e-28 1.3e-29 3.0e-31
4 Brain gene expression Fsip1 0.12 0.05 7.4e-11 0.11 0.12 0.12 0.11 3.5e-10 5.0e-11 1.7e-11 9.2e-11
5 Eye gene expression Fsip1 0.5 0.19 4.8e-03 0.05 0.06 0.02 0.06 5.8e-02 4.7e-02 1.6e-01 5.0e-02
6 PL gene expression Fsip1 0.16 0.06 0.0e+00 0.17 0.16 0.17 0.17 1.6e-18 9.6e-17 2.7e-18 5.3e-18
7 NAcc intron excision ratio chr3_125667103_125668848 0.04 0.02 1.1e-05 0.04 0.03 0.03 0.03 9.1e-07 9.9e-06 5.8e-06 5.0e-06
8 IL gene expression Fsip1 0.29 0.13 2.4e-04 0.13 0.17 0.14 0.14 5.9e-04 8.1e-05 3.7e-04 3.2e-04
9 NAcc gene expression Fsip1 0.44 0.11 0.0e+00 0.27 0.27 0.28 0.28 1.5e-41 1.1e-40 1.7e-42 5.2e-42
10 LHb gene expression Fsip1 0.21 0.13 7.4e-03 0.03 0.06 0.09 0.06 7.0e-02 1.3e-02 4.2e-03 1.9e-02
11 Adipose gene expression Fsip1 0.12 0.06 4.0e-12 0.07 0.08 0.08 0.08 3.3e-08 2.0e-09 5.2e-09 6.3e-09
12 Liver gene expression Fsip1 0.15 0.06 2.0e-15 0.12 0.11 0.11 0.11 9.6e-13 5.2e-12 4.3e-12 2.6e-12
13 NAcc intron excision ratio chr3_125667103_125670926 0.03 0.01 2.3e-03 0.02 0.01 0.01 0.02 1.9e-04 2.2e-03 3.2e-03 6.8e-04
14 pVTA alternative polyA NM_001013078.2 0.07 0.04 2.2e-04 0.02 0.03 0.02 0.02 8.1e-03 1.2e-03 1.7e-02 1.2e-02
15 NAcc alternative polyA XM_039104541.2 0.03 0.02 4.6e-03 0.01 0.01 0.01 0.02 1.8e-02 2.0e-03 3.7e-02 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.71.22.01.2-1.21.31.11.41.01.11.21.40.61.21.4-1.2-0.3-0.2
Area under the delay curve2.63.06.21.9-2.11.71.71.72.52.51.81.52.20.61.4-0.21.41.1
BMI with tail4.314.821.94.4-4.24.64.74.14.44.53.94.54.13.83.1-2.7-1.4-1.2
BMI without tail6.118.625.35.0-4.84.94.94.94.44.34.74.93.75.03.9-3.9-2.1-1.7
Body weight4.318.628.34.7-4.65.15.34.75.05.04.35.34.34.13.6-3.2-1.5-1.1
Weight adjusted by age0.71.12.61.6-1.61.01.20.81.41.30.91.01.40.50.60.10.30.3
Bone surface0.61.22.70.8-0.71.31.11.10.70.71.01.10.61.51.1-1.6-1.3-1.2
Bone volume0.91.73.21.1-1.01.61.41.41.11.11.11.31.01.51.3-1.8-1.2-1.2
Breakpoint value in progressive ratio session0.10.10.7-0.30.30.50.30.30.00.30.30.8-0.20.40.6-0.4-0.1-0.0
Number of licking bursts0.10.20.8-0.70.7-0.3-0.40.0-0.4-0.5-0.2-0.4-0.90.10.5-0.6-0.2-0.1
Context. condit. distance diff. score1.51.84.31.5-1.21.41.21.40.70.81.21.10.51.71.5-2.1-1.5-1.4
Locomotion velocity, session 13.84.06.2-2.21.9-2.3-2.3-1.9-1.7-1.6-1.8-2.1-2.0-2.5-1.12.22.22.1
Locomotion distance, session 11.92.43.9-1.31.1-2.0-1.9-1.4-1.5-1.5-1.2-1.8-1.9-1.6-0.81.71.71.6
Locomotion velocity, session 21.21.43.21.6-1.80.50.41.21.11.01.40.8-0.00.61.5-0.11.71.8
Locomotion distance, session 20.81.13.7-0.60.4-1.4-1.5-0.7-1.3-1.3-0.5-1.2-1.9-0.5-0.10.71.11.1
Locomotion velocity, session 30.50.61.30.7-0.90.50.40.71.11.11.00.10.50.30.8-0.21.10.8
Locomotion distance, session 30.91.02.61.1-1.00.80.51.10.50.51.30.6-0.11.51.4-1.6-0.4-0.5
Stereotopy head waving bouts, day 32.42.86.21.8-1.72.12.11.52.42.41.21.92.50.61.1-0.8-0.1-0.2
Stereotopy head waving duration, day 32.73.27.21.8-2.02.02.01.72.62.71.61.92.40.51.3-0.40.80.8
Locomotion velocity, session 70.70.81.51.1-1.00.90.81.10.70.81.00.80.31.11.2-1.2-0.4-0.4
Locomotion distance, session 70.30.41.30.10.10.1-0.00.2-0.6-0.50.10.0-0.70.90.4-1.1-1.1-1.1
Stereotopy head waving bouts, day 70.10.20.6-0.40.40.10.1-0.30.30.4-0.5-0.10.7-0.8-0.60.30.0-0.1
Stereotopy head waving duration, day 70.20.31.4-0.10.20.30.5-0.30.60.6-0.40.11.2-0.7-0.70.2-0.3-0.4
Locomotion velocity, session 81.61.94.42.0-2.11.21.01.61.51.51.71.00.71.11.7-0.80.80.7
Locomotion distance, session 80.40.61.70.9-0.80.20.10.8-0.1-0.10.80.2-0.81.21.3-1.2-0.4-0.4
Degree of sensitization distance1.21.22.5-1.31.5-0.9-0.7-1.3-1.3-1.3-1.6-0.8-0.4-1.0-1.50.6-0.9-0.8
Degree of sensitization stereotypy0.40.41.0-0.81.0-0.2-0.1-0.7-0.4-0.3-0.9-0.40.3-0.6-1.00.1-0.9-1.0
Conditioned locomotion1.31.53.21.8-1.51.41.21.41.00.90.91.30.71.11.4-1.6-0.9-0.8
Cocaine response after cond. corrected0.30.30.9-0.30.2-0.6-0.9-0.0-0.2-0.30.2-0.9-0.9-0.20.3-0.20.90.7
Cocaine response after cond. not corrected0.60.71.9-0.60.4-1.0-1.3-0.3-0.5-0.6-0.0-1.1-1.3-0.50.20.31.41.3
Cocaine response before conditioning0.50.61.7-0.50.3-0.9-0.7-0.7-0.6-0.6-0.5-0.5-0.7-0.7-0.51.31.01.2
Saline control response0.81.04.30.5-0.31.31.60.41.21.2-0.11.02.1-0.1-0.2-0.3-1.1-1.1
Bone: connectivity density0.10.10.40.3-0.20.50.60.10.40.4-0.10.70.6-0.1-0.20.1-0.3-0.3
Bone: cortical apparent density0.91.33.1-1.41.7-0.6-0.6-1.0-1.4-1.3-1.2-0.7-0.6-0.3-0.9-0.5-1.8-1.7
Bone: cortical area1.62.53.31.7-1.71.81.81.71.81.71.81.61.51.81.6-1.4-0.5-0.5
Bone: cortical porosity1.31.47.10.3-0.7-0.8-1.10.3-0.1-0.10.7-0.4-1.5-0.20.80.82.62.7
Bone: cortical porosity0.91.04.50.8-1.2-0.0-0.20.80.70.61.10.3-0.50.31.10.42.12.1
Bone: cortical thickness1.21.92.91.6-1.71.41.41.61.61.61.71.61.11.41.5-0.80.30.3
Bone: cortical thickness0.20.21.10.3-0.10.30.10.60.20.20.50.1-0.30.50.9-1.1-0.1-0.2
Bone: cortical tissue density0.91.22.9-1.41.7-0.5-0.5-1.0-1.3-1.2-1.2-0.7-0.5-0.4-0.9-0.5-1.6-1.6
Condit. Reinf. active minus inactive responses1.21.43.3-1.51.6-0.6-0.2-1.5-1.0-1.0-1.8-0.60.2-1.3-1.60.7-1.3-1.2
Condit. Reinf. active-inactive response ratio0.40.41.60.10.10.70.90.00.50.5-0.20.61.30.0-0.4-0.1-1.0-1.0
Condit. Reinf. active responses3.03.78.3-2.42.7-1.3-0.9-2.3-2.0-2.0-2.9-1.3-0.4-2.0-2.41.1-1.7-1.5
Condit. Reinf. inactive responses2.53.15.7-2.12.3-1.5-1.4-2.0-2.2-2.2-2.4-1.6-1.3-1.5-1.80.7-1.3-1.1
Incentive salience index mean2.83.46.8-2.42.5-1.6-1.1-2.3-2.0-2.0-2.6-1.3-0.6-2.0-2.31.6-0.8-0.6
Condit. Reinf. lever presses3.14.37.7-2.82.7-2.0-1.6-2.5-2.2-2.3-2.7-1.7-1.1-2.2-2.52.0-0.3-0.1
Condit. Reinf. active minus inactive responses0.60.84.4-0.20.50.50.8-0.3-0.2-0.1-0.80.50.90.0-0.6-0.6-2.1-1.9
Condit. Reinf. active-inactive response ratio0.50.63.00.20.00.60.80.0-0.00.0-0.20.60.80.5-0.3-0.6-1.7-1.6
Condit. Reinf. active responses0.91.26.3-0.00.40.91.2-0.10.10.2-0.70.71.40.2-0.5-0.9-2.5-2.3
Condit. Reinf. inactive responses0.50.62.2-0.10.30.71.1-0.10.50.5-0.60.41.5-0.3-0.5-0.3-1.5-1.4
Condit. Reinf. lever presses0.81.14.9-0.00.21.01.5-0.20.90.9-0.80.62.2-0.7-0.80.0-1.6-1.6
Condit. Reinf. lever reinforcers received0.91.25.9-0.40.70.71.1-0.5-0.00.0-1.10.51.4-0.3-0.9-0.4-2.4-2.2
Conditioned reinforcement - actives0.20.41.9-0.1-0.1-0.4-0.5-0.3-0.20.1-0.1-0.2-0.1-0.7-0.21.01.41.1
Conditioned reinforcement - inactives0.30.41.11.0-0.80.70.40.70.20.40.50.4-0.00.51.0-1.0-0.2-0.4
Conditioned locomotion0.60.83.1-0.30.0-0.1-0.0-0.50.50.7-0.3-0.20.8-1.3-0.71.81.61.3
Patch foraging indifference point 0 sec1.32.310.01.2-1.41.62.00.82.32.10.81.83.20.1-0.10.80.20.2
Patch foraging indifference point AUC1.21.73.0-1.31.2-1.4-1.5-1.5-1.4-1.1-1.4-1.1-1.2-1.7-1.01.41.11.1
Delay disc. indifference point, 0s delay0.50.52.30.3-0.50.30.5-0.10.90.90.10.51.5-0.6-0.51.00.90.7
Delay disc. indifference point, 16s delay1.11.23.00.8-1.10.70.71.01.61.61.20.61.00.01.00.21.71.5
Delay disc. indifference point, 2s delay1.21.43.01.7-1.61.41.30.91.11.10.70.91.70.90.6-0.8-1.0-1.2
Delay disc. indifference point, 24s delay1.01.12.4-1.41.1-1.0-0.9-1.1-0.5-0.5-1.0-1.2-0.3-1.6-1.01.51.30.8
Delay disc. indifference point, 4s delay0.90.92.21.4-1.50.80.80.81.31.30.70.71.2-0.00.8-0.00.90.7
Delay disc. indifference point, 8s delay5.05.812.12.5-2.82.72.72.53.53.42.62.43.01.32.0-0.71.10.8
Indifference point function ln k2.74.89.22.6-2.52.22.12.62.01.82.72.11.43.02.3-2.4-1.2-1.1
Indifference point function log k2.74.89.22.6-2.52.22.12.62.01.82.72.11.43.02.3-2.4-1.2-1.1
Patch foraging total patch changes 0 sec1.12.19.11.1-1.31.51.90.72.22.00.81.73.00.0-0.10.70.20.1
Patch foraging total patch changes 12 sec0.30.42.1-0.40.3-0.4-0.1-0.7-0.10.1-0.50.10.6-0.9-1.01.40.70.8
Patch foraging total patch changes 18 sec0.40.72.1-0.30.3-0.8-0.7-1.0-0.5-0.4-0.9-0.60.2-1.3-1.01.50.80.9
Patch foraging total patch changes 24 sec0.61.02.60.6-0.80.91.20.71.51.60.71.21.6-0.20.40.50.91.0
Patch foraging total patch changes 6 sec0.20.31.1-0.1-0.00.10.3-0.40.30.3-0.40.41.0-0.7-0.71.00.30.4
Patch foraging time to switch 0 sec0.61.33.9-1.01.1-0.9-0.6-1.6-0.7-0.8-1.5-0.90.3-1.5-2.01.6-0.2-0.1
Patch foraging water rate 0 sec0.81.63.80.9-0.71.41.41.41.00.91.01.00.81.41.4-2.0-1.4-1.6
Patch foraging water rate 12 sec0.51.04.30.8-0.70.70.31.10.0-0.00.90.2-0.71.51.7-2.1-0.9-0.9
Patch foraging water rate 18 sec1.01.63.31.0-1.21.31.11.71.21.01.71.20.31.71.8-1.7-0.1-0.2
Patch foraging water rate 24 sec1.62.37.11.0-0.71.51.31.20.50.40.91.20.41.91.2-2.7-2.5-2.5
Patch foraging water rate 6 sec0.60.82.2-0.70.8-0.3-0.6-0.1-1.1-1.1-0.4-0.7-1.50.40.6-1.4-1.1-1.2
Seeking ratio, delayed vs. immediate footshock0.30.41.40.4-0.10.40.30.3-0.2-0.40.10.5-0.20.70.5-1.1-1.2-0.9
Distance traveled before self-admin0.60.81.41.0-1.10.91.01.01.21.10.90.70.90.70.9-0.40.20.1
Distance traveled after self-admin0.10.20.60.1-0.20.50.60.40.40.40.50.80.50.50.3-0.3-0.20.0
Extensor digitorum longus weight0.52.03.41.6-1.71.51.21.61.61.71.81.61.21.51.3-0.90.30.2
Bone: elastic displacement0.10.10.40.2-0.30.10.20.10.50.50.30.20.4-0.1-0.10.50.60.5
Bone: elastic work0.71.02.70.9-0.91.31.30.81.31.40.71.11.60.60.3-0.3-0.4-0.5
Bone: endosteal estimation0.20.31.70.2-0.10.40.20.60.1-0.00.5-0.1-0.30.80.8-1.3-0.7-0.8
Bone: endosteal perimeter0.10.10.50.1-0.10.10.10.3-0.0-0.10.4-0.1-0.20.70.4-0.7-0.5-0.5
Epididymis fat weight0.51.93.81.6-1.91.01.01.61.51.42.01.40.31.41.5-0.41.11.2
Delta time in closed arm before/after self-admin0.50.52.4-0.00.30.20.20.0-0.6-0.50.0-0.3-0.50.70.4-1.1-1.3-1.5
Delta time in open arm before/after self-admin1.41.43.51.2-0.91.41.01.51.01.00.91.50.31.21.4-1.9-1.1-0.8
Diff in mean of infusions in LGA sessions0.60.72.3-1.01.1-0.00.1-0.9-0.4-0.4-1.2-0.20.4-0.8-1.20.4-1.2-1.5
Delay discount exponential model param2.02.24.6-1.71.9-1.4-1.4-1.5-2.1-2.1-1.5-1.2-1.9-0.5-1.30.2-1.3-1.0
Extinction: sum of active levers before priming0.30.40.9-0.60.5-0.6-0.6-0.7-0.5-0.3-0.5-0.6-0.5-0.9-0.40.90.80.5
Active lever presses in extinction session 60.50.52.70.2-0.4-0.2-0.3-0.10.10.40.10.1-0.1-0.60.21.11.61.5
Bone: final force1.32.13.51.6-1.41.61.51.40.80.91.21.50.91.91.2-1.8-1.7-1.6
Bone: final moment1.32.13.61.6-1.41.61.51.40.90.91.31.41.01.91.2-1.9-1.6-1.6
Food consumed during 24 hour testing period0.10.21.0-0.40.3-0.2-0.40.1-0.5-0.5-0.0-0.0-1.00.10.4-0.20.20.4
Glucose2.23.56.62.3-2.21.91.72.11.61.42.31.80.92.62.1-2.1-0.9-0.8
Heart weight2.64.06.32.5-2.42.22.22.22.12.12.12.21.82.12.0-1.5-0.6-0.6
Delay discount hyperbolic model param1.92.24.4-1.81.9-1.5-1.5-1.4-2.1-2.1-1.4-1.2-1.9-0.5-1.30.3-0.9-0.7
Intermittent access intake day 1-15 change1.12.36.42.1-1.91.20.61.90.71.01.81.3-0.51.82.5-2.00.20.6
Intermittent access intake escalation1.32.66.02.2-2.01.50.92.01.01.32.01.7-0.21.92.4-1.90.20.7
Intermittent access intake escalation 21.61.85.91.5-1.40.5-0.21.70.30.51.60.9-1.41.32.4-1.61.11.7
Intermitt. access day 1 inactive lever presses0.20.71.90.0-0.00.91.20.60.60.60.50.90.91.00.1-0.8-1.3-1.4
Intermitt. access day 15 inactive lever presses0.40.72.01.1-0.90.80.60.90.30.30.90.60.01.40.8-1.2-0.9-1.0
Intermitt. access escalation Index0.60.84.50.10.20.71.0-0.00.40.2-0.2-0.11.10.5-0.6-0.7-1.9-2.1
Intermittent access day 1 total infusions0.10.21.1-0.40.3-0.00.0-0.40.20.3-0.4-0.30.4-0.8-0.61.00.60.1
Intermittent access day 15 total infusions0.60.91.71.3-1.11.20.91.10.81.11.01.00.30.81.2-0.8-0.0-0.1
Intermittent access terminal intake (last 3 days)0.91.23.11.3-1.21.10.71.40.70.91.40.9-0.21.31.8-1.40.20.1
Intermittent access total infusions0.20.20.60.8-0.70.60.40.60.50.60.50.40.10.30.6-0.20.30.0
Intermittent access day 1 locomotion0.50.71.70.2-0.50.70.80.41.21.30.70.81.3-0.1-0.10.91.00.7
Intermittent access day 15 total locomotion0.61.02.51.1-1.01.20.91.40.91.11.11.00.21.01.6-1.20.10.1
Intermittent access total locomotion0.30.41.00.2-0.30.60.40.60.81.00.60.60.20.00.60.31.00.9
Intermittent access standard deviation0.71.43.91.9-1.70.3-0.21.30.30.31.40.3-1.11.22.0-1.20.81.0
Left kidney weight1.88.516.13.9-4.03.03.03.53.33.23.33.02.32.82.9-1.60.30.6
Right kidney weight3.114.227.05.0-5.23.83.84.34.34.44.34.33.23.33.6-1.51.01.5
Cocaine induced anxiety0.20.30.80.8-0.90.10.30.10.60.60.6-0.10.80.4-0.40.60.30.0
Post-drug Anxiety0.30.41.11.1-1.00.40.50.40.30.40.70.10.41.00.1-0.4-0.5-0.9
Baseline Anxiety0.20.21.0-0.10.30.20.10.1-0.4-0.3-0.20.1-0.30.30.3-1.0-0.9-0.9
Tail length1.76.811.72.9-2.82.82.63.12.22.23.03.01.23.42.9-3.0-1.3-0.9
Length with tail1.04.47.92.2-2.22.42.52.42.22.22.22.81.52.22.2-2.0-0.7-0.4
Length without tail0.61.93.51.3-1.41.71.71.51.61.71.31.91.21.01.7-1.1-0.00.2
Times rat made contact with spout0.10.10.3-0.40.30.20.2-0.10.30.4-0.20.20.5-0.5-0.30.50.20.3
Lifetime Intake0.20.20.40.5-0.50.50.30.40.60.60.50.40.30.10.50.10.60.4
Liver weight, left3.35.510.02.2-2.13.03.12.52.52.41.93.22.42.22.2-2.1-1.5-1.2
Liver weight, right2.23.97.12.1-2.02.42.52.02.72.51.72.32.41.41.6-1.3-0.5-0.4
Locomotor activity0.40.72.1-1.41.2-1.0-0.8-0.7-0.7-0.9-0.5-0.7-0.8-0.5-0.70.80.50.8
Locomotor testing distance0.30.61.4-1.20.9-1.1-0.8-0.8-0.8-1.0-0.5-0.8-0.7-0.4-0.80.80.30.5
Locomotor testing rearing1.42.85.3-1.91.8-2.0-1.9-1.8-2.1-2.3-1.6-1.7-1.8-1.0-1.61.1-0.10.1
Locomotion in novel chamber0.70.91.91.4-1.30.90.90.70.70.81.10.90.91.30.4-0.6-0.5-1.0
Locomotion in novel chamber post-restriction1.01.62.71.5-1.41.41.21.71.11.31.51.40.91.61.3-1.2-0.3-0.4
Fecal boli incidents, locomotor time 10.20.41.60.4-0.4-0.4-0.8-0.3-0.30.20.1-0.4-0.3-0.4-0.50.71.31.1
Change in fecal boli incidents, locomotor task2.12.14.21.3-1.41.81.51.61.11.11.62.10.92.01.5-1.6-0.9-0.6
Time >=10cm from walls, locomotor time 10.20.20.9-0.10.50.3-0.00.1-0.4-0.1-0.30.1-0.40.10.3-0.7-0.7-0.9
Bouts of movement, locomotor time 14.75.48.4-2.62.4-2.7-2.7-2.3-2.2-2.1-2.1-2.9-2.1-2.6-2.02.31.71.6
Total resting periods, locomotor time 14.95.59.0-2.52.5-2.7-2.7-2.5-2.5-2.2-2.3-3.0-2.0-2.6-2.22.21.31.1
Rest time, locomotor task time 10.10.20.5-0.10.2-0.3-0.5-0.6-0.7-0.4-0.5-0.10.0-0.3-0.70.6-0.00.1
Distance moved, locomotor task time 10.20.31.0-1.01.0-0.20.2-0.40.4-0.2-0.6-0.60.2-0.6-0.2-0.1-0.5-0.6
Vertical activity count, locomotor time 10.10.20.9-0.60.60.20.50.30.4-0.20.10.30.10.40.3-0.8-1.0-0.6
Time >=10cm from walls, locomotor time 23.65.410.12.1-1.83.03.12.32.73.01.83.22.91.81.5-1.5-1.4-1.2
Bouts of movement, locomotor time 20.30.51.7-0.20.40.90.80.00.40.7-0.30.41.0-0.00.0-0.6-1.2-1.3
Total resting periods, locomotor time 20.20.31.3-0.20.30.70.70.00.30.5-0.20.30.90.0-0.1-0.5-1.0-1.1
Rest time, locomotor task time 23.24.07.3-1.91.6-2.5-2.7-2.0-2.5-2.3-1.6-2.3-2.1-1.7-1.61.91.41.4
Distance moved, locomotor task time 21.21.53.50.8-0.61.51.91.01.81.30.61.41.70.70.7-0.9-1.1-1.0
Vertical activity count, locomotor time 22.63.56.51.3-0.92.32.61.62.01.61.22.42.11.81.2-1.9-2.3-2.0
Light reinforcement 10.61.55.0-0.50.70.41.1-1.20.50.4-1.50.42.2-1.4-2.01.4-1.4-1.3
Light reinforcement 21.01.62.7-1.31.3-1.2-1.2-1.6-1.3-1.2-1.7-1.2-0.8-1.5-1.51.30.10.2
Bone: marrow area0.10.31.50.2-0.10.40.20.60.10.10.5-0.0-0.20.80.8-1.2-0.7-0.7
Bone: maximum diameter0.81.42.31.0-1.01.41.41.21.11.11.21.11.21.50.9-1.3-1.0-1.1
Bone: maximum force1.62.84.21.9-1.82.02.01.71.51.61.62.01.61.91.4-1.5-1.2-1.1
Bone: maximum moment1.52.63.61.9-1.81.91.91.61.51.51.61.81.51.81.4-1.5-1.1-1.0
Mean time between licks in bursts0.20.62.4-0.1-0.1-0.7-1.0-0.2-0.6-0.5-0.1-0.3-1.2-0.50.20.71.51.6
Mean num. licks in bursts0.20.31.40.4-0.40.50.6-0.00.60.70.00.51.2-0.1-0.60.6-0.1-0.2
Cd content in liver0.50.61.20.9-0.80.90.80.70.70.80.71.01.10.70.4-0.7-0.4-0.5
Co content in liver0.60.71.51.1-1.20.30.10.80.90.91.20.50.20.60.7-0.01.21.2
Cu content in liver0.40.51.9-0.60.7-0.7-0.9-0.2-1.2-1.1-0.2-0.5-1.40.20.2-0.5-0.10.1
Fe content in liver2.73.37.6-2.52.7-1.2-1.0-1.9-2.1-2.1-2.2-1.3-0.9-1.1-1.90.1-2.0-2.1
K content in liver0.30.30.70.8-0.60.30.20.60.20.10.50.2-0.20.70.7-0.8-0.4-0.3
Mg content in liver1.61.64.41.4-1.21.31.01.50.90.81.40.90.51.81.5-2.1-1.0-0.9
Mn content in liver1.41.63.01.2-1.11.61.71.31.71.61.01.31.70.80.9-0.9-0.7-0.6
Na content in liver0.91.02.6-0.70.8-1.2-1.3-0.9-1.6-1.6-1.0-1.1-1.6-0.5-0.40.2-0.10.0
Rb content in liver4.24.86.92.6-2.62.32.12.62.42.52.62.51.82.32.3-1.8-0.10.1
Se content in liver0.20.20.80.20.00.60.50.30.20.2-0.10.50.50.10.2-0.8-0.9-0.7
Sr content in liver0.10.10.7-0.1-0.1-0.2-0.2-0.00.10.10.10.1-0.3-0.20.20.40.90.9
Zn content in liver0.80.92.5-0.91.0-0.8-1.0-0.5-1.5-1.6-0.5-0.6-1.50.4-0.2-0.7-1.0-0.8
Bone: minimum diameter1.32.44.91.7-1.81.51.61.72.22.11.91.21.51.21.5-0.60.70.6
Time in familiar zone, hab. session 11.11.12.1-1.11.0-1.3-1.4-1.0-1.3-1.2-0.9-1.1-1.4-0.9-0.60.80.70.5
Time in novel zone, hab. session 12.42.43.91.7-1.41.82.01.41.61.71.21.82.01.41.0-1.3-1.2-1.1
Total zone transitions, hab. session 11.01.42.3-1.10.8-1.5-1.4-1.1-1.1-1.0-0.8-1.0-1.3-1.2-0.61.51.51.5
Total locomotion distance, hab. session 11.01.42.6-1.10.9-1.5-1.3-1.2-1.0-1.0-0.9-1.2-1.1-1.3-0.91.61.31.3
Locomotion velocity, hab. session 11.72.44.4-1.61.3-1.9-1.7-1.5-1.3-1.3-1.2-1.5-1.4-1.7-1.22.11.71.6
Time in familiar zone, hab. session 20.20.20.9-0.40.50.20.2-0.10.20.2-0.2-0.30.6-0.1-0.3-0.4-0.7-0.9
Time in novel zone, hab. session 20.80.92.21.4-1.50.80.80.90.90.91.01.20.60.70.9-0.20.40.7
Total zone transitions, hab. session 20.40.61.8-0.1-0.1-0.8-0.9-0.2-0.6-0.7-0.1-0.5-1.3-0.30.30.71.31.3
Total locomotion distance, hab. session 20.10.10.4-0.20.1-0.4-0.3-0.4-0.4-0.4-0.5-0.4-0.4-0.5-0.30.60.30.2
Locomotion velocity, hab. session 20.30.40.8-0.60.5-0.8-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.50.90.40.4
Novel to familiar place preference ratio0.80.82.50.7-0.51.21.40.61.11.10.40.91.60.40.1-0.5-1.0-1.0
Novelty place preference0.80.82.50.7-0.61.21.30.61.21.10.40.81.60.50.1-0.5-0.8-0.9
Time in novel zone, NPP test0.80.82.60.7-0.51.21.30.61.21.10.30.81.60.40.0-0.5-1.0-1.0
Total zone transitions, NPP test1.31.85.5-0.60.4-1.7-1.9-0.7-1.4-1.4-0.5-1.4-2.4-0.80.10.91.81.8
Total locomotion distance, NPP test0.70.93.1-0.2-0.1-1.1-1.2-0.3-0.6-0.7-0.1-0.9-1.5-0.50.20.91.81.8
Locomotion velocity, NPP test0.81.14.1-0.1-0.2-1.2-1.3-0.3-0.7-0.70.0-0.7-1.6-0.50.21.02.02.0
Intraocular pressure0.30.51.2-0.90.6-0.6-0.5-0.90.0-0.2-0.5-0.60.1-0.9-1.11.10.80.4
Delta distance traveled before/after self-admin0.30.30.9-0.90.8-0.5-0.4-0.6-0.5-0.6-0.6-0.1-0.1-0.5-0.70.5-0.10.2
Delta ambulatory time before/after self-admin0.81.01.8-1.31.3-0.9-0.8-1.2-0.9-0.9-1.1-0.7-0.2-1.1-1.41.20.00.2
Parametrial fat weight0.10.21.20.2-0.4-0.4-0.1-0.5-0.3-0.2-0.2-0.20.2-0.3-0.91.10.50.4
Pavlov. Cond. lever latency1.72.23.61.9-1.61.71.51.41.41.51.31.31.51.51.1-1.8-1.1-1.4
Pavlov. Cond. magazine entry latency0.60.82.6-0.90.9-0.5-0.0-1.2-0.7-0.7-1.3-0.30.4-0.9-1.61.4-0.7-0.5
Pavlov. Cond. change in total contacts0.60.62.0-0.90.8-0.9-0.8-0.5-1.3-1.3-0.6-0.3-1.4-0.0-0.20.4-0.20.3
Pavlov. Cond. index score1.51.93.8-1.71.5-1.5-1.1-1.6-1.4-1.4-1.5-1.0-0.8-1.4-1.72.00.50.7
Pavlov. Cond. latency score1.62.04.5-1.81.5-1.5-1.1-1.6-1.3-1.3-1.5-1.1-0.7-1.6-1.72.10.71.0
Pavlov. Cond. lever contacts2.12.54.0-2.01.7-1.8-1.5-1.6-1.6-1.6-1.6-1.4-1.5-1.6-1.52.01.01.2
Pavlov. Cond. magazine entry number0.30.31.10.5-0.40.3-0.20.70.40.40.8-0.1-0.40.51.1-1.10.50.2
Pavlov. Cond. intertrial magazine entries0.30.42.00.3-0.00.50.20.40.00.10.3-0.1-0.00.60.6-1.4-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.1.61.93.6-1.71.4-1.6-1.2-1.5-1.4-1.5-1.4-1.1-1.1-1.4-1.51.90.70.9
Pavlov. Cond. response bias1.21.52.4-1.51.4-1.3-1.0-1.4-1.6-1.6-1.5-0.9-1.0-1.0-1.41.3-0.20.1
Pavlov. Cond. lever latency1.52.17.1-1.00.8-1.8-2.2-0.7-1.6-1.5-0.1-1.3-2.7-0.4-0.00.71.91.8
Pavlov. Cond. magazine entry latency1.01.25.5-0.30.60.81.1-0.40.20.2-1.00.41.5-0.3-0.8-0.3-2.3-2.3
Pavlov. Cond. change in total contacts0.50.94.9-0.20.40.71.0-0.20.00.0-0.60.51.10.2-0.5-0.5-2.2-2.0
Pavlov. Cond. index score1.31.77.40.30.11.31.70.10.60.6-0.50.91.90.3-0.4-0.9-2.7-2.6
Pavlov. Cond. latency score1.01.46.00.30.01.21.50.10.50.5-0.40.81.60.4-0.3-0.9-2.5-2.4
Pavlov. Cond. lever contacts1.72.38.40.8-0.51.82.30.61.61.5-0.11.32.90.2-0.2-0.7-2.1-2.0
Pavlov. Cond. magazine entry number0.91.15.80.1-0.5-0.9-1.20.2-0.2-0.20.8-0.5-1.4-0.00.50.62.42.4
Pavlov. Cond. intertrial magazine entries0.40.62.50.4-0.60.30.20.71.00.90.80.50.1-0.00.80.11.51.6
Pavlov. Cond. lever-magazine prob. diff.1.11.56.90.10.21.21.5-0.00.50.5-0.60.71.80.2-0.5-0.8-2.6-2.6
Pavlov. Cond. response bias2.02.78.40.6-0.21.92.40.41.31.3-0.41.42.90.3-0.4-1.0-2.9-2.7
Time in closed arm before self-admin2.33.07.8-2.82.6-1.7-1.5-1.9-1.6-1.7-2.0-1.4-1.1-1.7-1.81.4-0.10.0
Time in closed arm after self-admin2.02.24.3-1.92.1-1.1-0.9-1.7-1.9-1.7-1.8-1.4-0.8-1.0-1.50.4-1.3-1.5
Time in open arm before self-admin0.50.51.31.2-1.10.70.80.61.10.80.70.21.20.40.4-0.20.2-0.1
Time in open arm after self-admin3.33.65.62.4-2.22.11.72.32.01.92.02.10.91.92.4-2.1-0.4-0.1
Bone: periosteal estimation0.61.32.01.1-1.11.31.21.31.21.11.30.90.81.41.3-1.4-0.6-0.6
Bone: periosteal perimeter0.91.62.61.5-1.61.31.31.41.51.41.61.21.11.41.3-0.80.1-0.0
Bone: post-yield work0.30.42.10.2-0.3-0.5-0.70.2-0.6-0.70.4-0.3-1.50.50.7-0.20.60.8
Progressive ratio test 1 active lever presses0.10.20.6-0.50.50.10.0-0.4-0.1-0.1-0.5-0.40.2-0.4-0.40.3-0.4-0.8
Progressive ratio test 1 breakpoint0.10.20.5-0.40.50.0-0.1-0.4-0.2-0.2-0.6-0.40.1-0.5-0.40.3-0.3-0.7
Progressive ratio test 1 inactive lever presses0.20.31.4-0.30.5-0.2-0.1-0.4-0.5-0.5-0.4-0.5-0.30.0-0.5-0.1-0.8-1.2
Progressive ratio test 2 active lever presses0.20.21.20.00.20.70.6-0.00.10.4-0.30.40.5-0.0-0.1-0.2-0.9-1.1
Progressive ratio test 2 breakpoint0.30.31.20.20.00.90.70.10.30.5-0.10.60.60.10.0-0.3-0.9-1.1
Progressive ratio test 2 inactive lever presses0.10.20.60.4-0.30.70.60.40.30.50.30.20.20.50.4-0.4-0.6-0.8
Incentive Sensitization - Responses0.20.20.50.5-0.40.70.60.40.50.70.40.60.40.30.4-0.2-0.1-0.2
Incentive Sensitization - Breakpoint0.10.20.50.5-0.40.70.60.40.50.70.30.60.50.20.3-0.1-0.2-0.3
Sum of active levers in priming session hrs 5-60.30.20.90.6-0.4-0.2-0.50.1-0.6-0.20.00.3-1.00.10.7-0.20.40.7
Progressive ratio0.10.20.6-0.70.8-0.10.2-0.4-0.3-0.5-0.60.1-0.0-0.3-0.2-0.2-0.7-0.6
Food seeking constrained by brief footshock0.00.00.1-0.00.10.10.20.00.10.1-0.20.00.2-0.2-0.00.0-0.2-0.4
Seeking ratio, punishment vs. effort0.00.00.20.5-0.40.0-0.10.00.10.20.0-0.30.2-0.1-0.10.20.2-0.0
Retroperitoneal fat weight2.08.316.63.2-3.03.54.12.33.23.12.13.24.02.41.1-1.5-2.3-2.5
Reaction time number correct2.14.07.32.2-2.12.21.72.51.51.42.22.10.82.62.6-2.7-1.0-0.7
Reaction time mean minus median0.20.61.20.8-0.60.91.00.70.91.00.51.11.00.40.5-0.5-0.3-0.3
Reaction time mean minus median AUC0.92.33.71.8-1.51.81.91.61.81.81.41.81.71.31.2-1.2-0.7-0.7
Reaction time num false alarms0.10.10.6-0.80.7-0.2-0.1-0.1-0.0-0.1-0.2-0.3-0.2-0.2-0.20.40.10.1
Reaction time num false alarms AUC0.20.31.3-1.11.1-0.4-0.3-0.4-0.4-0.5-0.4-0.5-0.3-0.2-0.60.4-0.3-0.3
Reaction time trials correct on left2.14.07.32.2-2.12.21.72.51.51.42.22.10.82.62.6-2.7-1.0-0.7
Reaction time trials on left2.13.97.22.2-2.02.21.72.51.51.42.22.00.82.62.5-2.7-1.1-0.8
Reaction time mean0.60.92.2-1.31.5-0.4-0.4-1.0-0.9-0.9-1.3-0.5-0.0-0.7-1.1-0.0-1.2-1.3
Reaction time mean AUC0.30.51.5-0.81.1-0.1-0.0-0.6-0.5-0.5-0.8-0.20.2-0.4-0.8-0.2-1.2-1.2
Median of all reaction times1.52.14.7-2.02.2-1.1-1.1-1.7-1.5-1.7-1.9-1.1-0.6-1.2-1.70.4-1.2-1.3
Reaction time omissions0.20.31.3-0.00.20.20.5-0.20.60.5-0.6-0.31.1-0.8-0.70.5-0.2-0.4
Reaction time false alarm rate1.11.53.6-1.91.8-1.2-1.0-1.4-0.9-0.9-1.3-1.3-0.5-1.3-1.71.50.30.0
Reaction time premature initiation rate2.02.86.9-1.71.8-1.4-1.1-2.3-1.7-1.5-2.2-1.6-0.5-1.6-2.61.5-1.0-1.2
Reaction time premature initiations0.40.73.0-0.50.7-0.1-0.1-0.8-0.8-0.7-0.9-0.4-0.1-0.1-1.1-0.2-1.7-1.7
Std. dev. reaction times0.50.92.80.6-0.41.11.30.61.11.10.41.11.70.40.2-0.6-0.9-1.0
Reaction time trials completed2.13.97.22.2-2.02.21.72.51.51.42.22.00.82.62.5-2.7-1.1-0.8
Reaction time trials AUC2.03.87.82.1-1.92.21.72.31.31.22.02.00.82.62.4-2.8-1.4-1.2
Run reversals in cocaine runway, females0.50.51.50.6-0.6-0.1-0.40.7-0.2-0.30.8-0.5-1.01.11.2-0.90.1-0.0
Run reversals in cocaine runway, males0.30.30.4-0.50.5-0.6-0.7-0.5-0.6-0.6-0.5-0.6-0.6-0.5-0.30.20.10.3
Latency to leave start box in cocaine runway0.40.51.8-0.70.9-0.1-0.2-0.5-0.3-0.7-0.7-0.80.3-0.1-1.0-0.2-1.2-1.4
Latency to leave start box in cocaine runway, F0.30.30.9-0.40.5-0.7-0.7-0.6-0.3-0.8-0.5-0.9-0.2-0.5-0.80.30.10.2
Latency to leave start box in cocaine runway, M1.51.49.3-0.40.70.80.7-0.1-0.2-0.2-0.5-0.00.60.7-0.5-1.0-2.7-3.0
Std. dev. time between licks in bursts1.11.52.91.1-1.31.21.31.31.71.71.31.41.40.71.1-0.30.80.9
Total sessions with >9 infusions0.30.31.2-0.40.20.10.1-0.30.40.5-0.10.10.7-0.8-0.41.11.00.6
Short access day 1 total inactive lever presses1.01.32.91.6-1.70.40.61.31.21.11.60.50.41.01.2-0.21.31.3
Short access day 10 total inactive lever presses0.20.62.20.8-0.60.30.10.7-0.3-0.20.70.0-0.51.50.6-1.2-1.1-1.1
Short access day 1 total infusions0.20.21.4-0.40.2-0.2-0.1-0.10.20.2-0.0-0.20.2-0.60.00.71.20.8
Short access day 10 total infusions0.20.31.4-0.30.3-0.4-0.3-0.7-0.0-0.1-0.5-0.40.3-0.9-0.81.20.60.3
Short access total infusions0.10.20.8-0.1-0.00.10.1-0.10.40.40.10.10.4-0.5-0.10.70.90.6
Short access day 1 locomotion0.30.41.3-0.80.6-0.3-0.3-0.9-0.4-0.1-0.7-0.10.2-1.0-0.81.10.60.2
Short access day 10 total locomotion1.22.36.01.2-1.60.80.71.52.01.91.91.20.60.61.50.42.42.4
Short access total locomotion0.70.92.50.4-0.80.40.50.31.31.30.70.71.1-0.2-0.01.31.61.4
One hour access (0.3 mA shock)0.50.62.20.7-0.40.5-0.00.9-0.0-0.10.6-0.1-0.91.01.4-1.5-0.7-0.5
Compulsive drug intake0.30.41.11.0-0.8-0.2-0.40.6-0.0-0.20.8-0.2-0.81.00.9-0.7-0.00.4
One hour access (shock baseline)0.10.10.3-0.20.40.20.1-0.3-0.10.1-0.5-0.30.3-0.6-0.30.3-0.3-0.6
Social response proportion2.32.69.3-1.31.9-0.5-0.2-1.4-1.3-1.6-2.1-1.1-0.0-0.7-1.7-0.4-3.1-3.0
Social responses2.73.57.3-2.02.4-1.4-1.1-2.2-2.0-2.2-2.7-1.4-0.6-1.5-2.20.6-2.2-2.0
Social time0.30.52.8-0.40.50.20.2-0.1-0.1-0.4-0.20.00.30.5-0.4-0.9-1.7-1.5
Soleus weight0.10.41.3-0.91.0-0.1-0.2-0.6-0.5-0.5-0.6-0.50.1-0.2-0.8-0.2-1.1-1.1
Bone: stiffness0.71.11.81.3-1.21.21.31.10.70.80.91.30.81.31.0-1.0-1.0-0.9
Tibialis anterior weight0.31.15.8-0.10.60.80.7-0.00.00.0-0.40.31.00.4-0.5-1.3-2.3-2.4
Time to tail flick, vehicle, before self-admin0.60.71.90.8-1.00.80.80.70.70.80.91.41.00.80.8-0.40.20.4
Time to tail flick, vehicle, after self-admin1.21.63.01.2-1.51.31.11.51.21.01.61.40.71.71.4-1.6-0.4-0.4
Time to tail flick, test, before self-admin0.10.10.3-0.40.30.20.2-0.3-0.10.2-0.30.10.6-0.3-0.30.4-0.2-0.3
Time to tail flick, test, after self-admin1.01.12.91.1-1.31.31.20.81.01.40.81.71.40.50.8-0.30.00.1
Delta time to tail flick, vehicle, before/after SA1.51.52.91.4-1.31.31.11.51.11.01.31.00.41.51.4-1.7-0.7-0.7
Delta time to tail flick, test, before/after SA0.40.41.20.6-0.70.60.70.50.70.70.61.10.60.40.4-0.20.20.3
Tibia length0.41.22.31.0-1.50.81.20.81.31.31.11.41.20.50.50.91.11.2
Ambulatory time before self-admin0.81.22.21.2-1.31.21.41.11.51.41.11.11.30.70.9-0.40.30.1
Ambulatory time after self-admin0.10.10.3-0.60.40.30.3-0.1-0.10.0-0.10.50.20.2-0.1-0.2-0.5-0.5
Bone: tissue strength0.30.30.70.7-0.80.40.30.60.40.50.70.40.00.50.6-0.00.60.6
Total heroin consumption0.20.21.1-0.30.1-0.1-0.5-0.1-0.30.1-0.20.2-0.4-0.60.20.41.00.9
Bone: trabecular number1.42.34.31.8-1.51.81.41.81.01.11.41.80.61.81.8-2.1-1.2-1.0
Bone: trabecular spacing1.21.64.5-1.51.4-0.8-0.4-1.6-0.1-0.1-1.4-1.01.0-2.0-2.12.00.60.4
Bone: trabecular thickness0.30.30.8-0.30.4-0.2-0.5-0.1-0.9-0.8-0.2-0.4-0.90.40.2-0.8-0.8-0.7
Bone: trabecular tissue density1.92.912.6-1.21.0-2.1-2.4-0.7-2.5-2.4-0.4-1.6-3.60.10.5-0.01.01.3
Water consumed over 24 hours0.50.62.0-1.31.4-0.3-0.3-0.8-0.8-0.7-1.1-0.5-0.3-0.7-0.70.1-0.8-0.8
Number of responses in last shaping day0.91.02.5-1.11.1-0.9-0.8-1.2-0.5-0.5-1.2-1.0-0.2-1.6-1.11.50.80.7