Hub : Genes

Foxk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	isoform ratio	NM_001107075.1	0.29	0.13	7.1e-03	0.02	0.03	0.02	0.01	5.6e-02	1.3e-02	5.4e-02	8.6e-02
2	Brain	gene expression	Foxk2	0.07	0.04	3.1e-04	0.05	0.04	0.03	0.05	1.3e-05	1.7e-04	3.5e-04	3.9e-05
3	PL	gene expression	Foxk2	0.06	0.04	8.9e-03	0.03	0.01	0.02	0.03	5.9e-04	9.3e-03	3.8e-03	1.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.5	-0.7	0.3	-0.4
Area under the delay curve	0.1	0.2	0.3	0.2	-0.4	0.5
BMI with tail	1.5	4.8	9.0	-3.0	-1.7	1.5
BMI without tail	3.2	6.5	7.8	2.0	2.8	-2.8
Body weight	0.8	3.4	6.8	-2.6	-1.5	1.2
Weight adjusted by age	1.3	1.5	3.5	-1.9	-0.7	0.6
Bone surface	0.2	0.4	0.7	0.1	0.8	-0.8
Bone volume	0.2	0.3	0.5	-0.0	0.7	-0.7
Breakpoint value in progressive ratio session	1.1	1.2	1.3	1.1	-1.1	1.1
Number of licking bursts	0.4	0.5	0.9	0.3	0.8	-0.9
Context. condit. distance diff. score	2.1	2.5	3.4	0.9	1.8	-1.8
Locomotion velocity, session 1	2.0	2.2	3.0	-1.1	-1.5	1.7
Locomotion distance, session 1	0.6	0.8	2.2	-1.5	-0.2	0.3
Locomotion velocity, session 2	0.6	0.6	0.9	-0.5	-0.9	0.9
Locomotion distance, session 2	0.2	0.2	0.6	-0.8	0.1	-0.2
Locomotion velocity, session 3	1.3	1.6	2.0	-1.0	-1.3	1.4
Locomotion distance, session 3	0.8	0.9	1.1	-0.7	-1.0	1.1
Stereotopy head waving bouts, day 3	1.5	1.7	2.4	-1.5	-1.1	1.3
Stereotopy head waving duration, day 3	1.2	1.5	2.5	-1.6	-0.9	1.0
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	0.2	-0.1
Locomotion distance, session 7	0.6	0.7	0.9	0.9	0.8	-0.8
Stereotopy head waving bouts, day 7	0.8	0.8	1.6	-1.3	-0.7	0.7
Stereotopy head waving duration, day 7	0.5	0.7	1.4	-1.2	-0.5	0.6
Locomotion velocity, session 8	0.5	0.6	1.7	-1.3	-0.0	0.0
Locomotion distance, session 8	1.5	2.3	3.5	-0.2	1.8	-1.9
Degree of sensitization distance	2.9	2.9	3.1	1.6	1.7	-1.7
Degree of sensitization stereotypy	0.3	0.3	0.7	-0.8	-0.4	0.4
Conditioned locomotion	1.4	1.6	2.4	0.5	1.5	-1.6
Cocaine response after cond. corrected	0.5	0.6	0.9	0.3	-0.9	0.9
Cocaine response after cond. not corrected	0.4	0.5	0.7	0.4	-0.9	0.8
Cocaine response before conditioning	0.2	0.2	0.4	0.1	0.4	-0.6
Saline control response	0.6	0.8	1.1	0.9	0.8	-1.0
Bone: connectivity density	0.4	0.6	1.0	0.0	1.0	-1.0
Bone: cortical apparent density	0.4	0.5	0.8	-0.2	-0.8	0.9
Bone: cortical area	10.7	16.2	31.6	-5.6	-2.9	2.9
Bone: cortical porosity	2.6	2.8	4.2	-0.7	-2.1	1.9
Bone: cortical porosity	1.8	1.9	2.8	-0.8	-1.7	1.6
Bone: cortical thickness	17.9	29.5	48.5	-7.0	-4.4	4.5
Bone: cortical thickness	11.4	13.2	16.9	-4.1	-3.4	3.3
Bone: cortical tissue density	0.3	0.4	0.6	0.1	-0.7	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.2	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.3	-1.2	-0.4	0.4
Condit. Reinf. active responses	0.7	0.9	1.1	0.7	1.0	-1.0
Condit. Reinf. inactive responses	1.8	2.1	3.0	1.7	1.3	-1.3
Incentive salience index mean	0.4	0.5	0.7	0.4	0.8	-0.8
Condit. Reinf. lever presses	1.2	1.5	1.9	1.4	1.2	-1.2
Condit. Reinf. active minus inactive responses	1.1	1.3	3.5	-1.9	-0.4	0.5
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.9	-1.7	-1.0	1.0
Condit. Reinf. active responses	0.3	0.4	1.3	-1.1	0.2	0.0
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.1	0.5	-0.2
Condit. Reinf. lever presses	0.3	0.4	0.7	0.4	0.8	-0.7
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.8	0.4	-0.2
Conditioned reinforcement - actives	0.3	0.3	0.3	0.6	0.6	-0.5
Conditioned reinforcement - inactives	0.8	0.9	2.5	1.6	-0.2	0.1
Conditioned locomotion	0.3	0.3	0.5	0.7	0.5	-0.5
Patch foraging indifference point 0 sec	0.2	0.4	0.5	0.7	0.5	-0.5
Patch foraging indifference point AUC	0.3	0.3	0.3	0.6	0.5	-0.5
Delay disc. indifference point, 0s delay	1.4	1.5	2.5	-1.6	-0.9	1.1
Delay disc. indifference point, 16s delay	0.5	0.5	0.9	1.0	0.7	-0.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	-0.3	-0.6	0.6
Delay disc. indifference point, 24s delay	0.9	0.8	1.2	-0.4	-1.1	1.0
Delay disc. indifference point, 4s delay	0.5	0.6	0.6	-0.7	-0.7	0.8
Delay disc. indifference point, 8s delay	0.6	0.6	0.9	-0.0	-0.9	1.0
Indifference point function ln k	0.8	1.1	2.5	-1.6	-0.6	0.7
Indifference point function log k	0.8	1.1	2.5	-1.6	-0.6	0.7
Patch foraging total patch changes 0 sec	0.2	0.3	0.4	0.7	0.5	-0.5
Patch foraging total patch changes 12 sec	0.4	0.6	1.5	1.2	0.3	-0.4
Patch foraging total patch changes 18 sec	0.7	0.9	1.2	0.6	1.0	-1.1
Patch foraging total patch changes 24 sec	0.2	0.2	0.3	0.5	0.5	-0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.6	0.2	-0.2
Patch foraging time to switch 0 sec	0.1	0.1	0.2	0.5	-0.2	0.1
Patch foraging water rate 0 sec	0.7	1.1	1.5	1.2	1.1	-0.9
Patch foraging water rate 12 sec	0.4	0.6	1.2	-1.1	-0.6	0.6
Patch foraging water rate 18 sec	0.3	0.3	0.9	-0.9	0.3	-0.2
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.7	0.6	-0.4
Patch foraging water rate 6 sec	0.9	1.3	1.5	-1.2	-1.0	1.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	0.2	-0.2
Distance traveled before self-admin	0.2	0.3	0.4	-0.2	-0.6	0.6
Distance traveled after self-admin	6.9	7.7	9.6	3.1	2.6	-2.6
Extensor digitorum longus weight	0.3	1.3	2.1	-0.2	1.3	-1.5
Bone: elastic displacement	1.0	1.1	1.7	-1.3	-0.9	0.9
Bone: elastic work	7.2	9.3	12.5	-3.5	-2.8	2.8
Bone: endosteal estimation	1.0	2.3	2.9	1.1	1.6	-1.7
Bone: endosteal perimeter	0.2	0.5	0.9	0.1	0.8	-0.9
Epididymis fat weight	0.2	0.5	0.7	0.7	0.5	-0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.2	0.3	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.5	0.1	-0.2
Diff in mean of infusions in LGA sessions	0.6	0.7	2.0	1.4	0.3	-0.2
Delay discount exponential model param	0.3	0.3	0.5	-0.2	0.6	-0.7
Extinction: sum of active levers before priming	4.4	4.4	4.7	-2.2	-2.1	2.0
Active lever presses in extinction session 6	3.9	3.8	5.5	-0.6	-2.3	2.3
Bone: final force	8.1	13.0	21.7	-4.7	-3.0	2.9
Bone: final moment	8.2	13.3	22.9	-4.8	-3.0	2.9
Food consumed during 24 hour testing period	1.4	1.6	2.0	1.0	1.4	-1.4
Glucose	6.9	10.3	14.6	-1.6	-3.7	3.8
Heart weight	3.5	4.9	9.0	-3.0	-1.8	1.7
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.1	0.7	-0.7
Intermittent access intake day 1-15 change	4.5	4.5	8.7	2.9	1.5	-1.6
Intermittent access intake escalation	6.4	6.3	11.6	3.4	1.9	-1.9
Intermittent access intake escalation 2	2.0	1.9	5.3	2.3	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.7	1.3	-0.2	0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.3	0.6	0.5	-0.5
Intermitt. access escalation Index	2.1	1.9	2.4	1.0	1.5	-1.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.3	0.2
Intermittent access day 15 total infusions	1.7	1.9	3.6	1.9	1.0	-1.1
Intermittent access terminal intake (last 3 days)	2.1	2.2	4.7	2.2	1.0	-1.0
Intermittent access total infusions	0.7	0.8	1.5	1.2	0.6	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.5	-0.3	0.2
Intermittent access day 15 total locomotion	0.3	0.3	0.7	0.8	0.4	-0.3
Intermittent access total locomotion	0.2	0.3	0.8	0.9	0.0	-0.1
Intermittent access standard deviation	1.2	1.3	1.5	0.9	-1.2	1.2
Left kidney weight	3.4	9.6	17.2	-4.2	-2.5	2.3
Right kidney weight	3.2	9.0	16.0	-4.0	-2.5	2.2
Cocaine induced anxiety	2.6	3.0	4.5	-0.4	-2.1	2.1
Post-drug Anxiety	1.8	2.0	2.9	-0.3	-1.7	1.7
Baseline Anxiety	0.3	0.3	0.9	-0.9	0.1	-0.1
Tail length	4.2	12.6	14.5	3.8	3.4	-3.4
Length with tail	0.0	0.1	0.2	-0.2	-0.5	0.4
Length without tail	8.5	18.6	20.0	-4.1	-4.5	4.4
Times rat made contact with spout	1.9	2.2	3.6	1.9	1.2	-1.2
Lifetime Intake	0.5	0.6	1.3	1.2	0.4	-0.5
Liver weight, left	1.0	1.7	2.4	-0.6	-1.5	1.5
Liver weight, right	0.1	0.1	0.2	-0.4	-0.5	0.2
Locomotor activity	0.0	0.1	0.1	-0.0	-0.2	0.3
Locomotor testing distance	0.0	0.1	0.2	-0.4	0.2	-0.2
Locomotor testing rearing	1.7	2.6	3.1	1.8	1.5	-1.6
Locomotion in novel chamber	0.1	0.2	0.5	-0.7	0.1	-0.2
Locomotion in novel chamber post-restriction	1.3	1.6	1.7	1.2	1.3	-1.3
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	0.3	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.4	1.2	-0.4	0.4
Time >=10cm from walls, locomotor time 1	2.8	2.9	3.5	1.4	1.8	-1.9
Bouts of movement, locomotor time 1	0.8	0.8	1.6	-1.3	-0.7	0.7
Total resting periods, locomotor time 1	0.7	0.8	1.3	-1.1	-0.8	0.7
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.2	-0.2	0.3
Distance moved, locomotor task time 1	1.4	1.6	4.1	2.0	0.5	-0.6
Vertical activity count, locomotor time 1	0.6	0.6	1.0	1.0	0.7	-0.7
Time >=10cm from walls, locomotor time 2	1.8	1.9	5.0	-2.2	-0.6	0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.3	-0.3	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	0.1	-0.1
Rest time, locomotor task time 2	1.6	1.8	2.0	1.4	1.3	-1.3
Distance moved, locomotor task time 2	1.0	1.2	1.5	-0.8	-1.2	1.2
Vertical activity count, locomotor time 2	1.1	1.2	1.7	-1.3	-0.9	1.0
Light reinforcement 1	0.9	1.7	2.5	0.6	1.6	-1.4
Light reinforcement 2	0.1	0.1	0.2	0.2	0.4	-0.4
Bone: marrow area	1.0	2.1	2.7	1.1	1.6	-1.6
Bone: maximum diameter	1.6	2.9	7.7	-2.8	-0.7	0.8
Bone: maximum force	6.9	11.9	21.1	-4.6	-2.8	2.6
Bone: maximum moment	6.9	11.9	21.8	-4.7	-2.7	2.6
Mean time between licks in bursts	0.0	0.0	0.1	0.2	-0.3	0.1
Mean num. licks in bursts	0.2	0.2	0.7	0.8	0.2	-0.0
Cd content in liver	0.4	0.4	0.4	-0.6	-0.6	0.6
Co content in liver	0.3	0.3	0.5	0.5	0.7	-0.6
Cu content in liver	0.3	0.4	0.6	-0.3	-0.7	0.8
Fe content in liver	0.7	0.8	0.9	0.9	0.8	-0.9
K content in liver	3.6	3.5	3.6	1.8	1.9	-1.9
Mg content in liver	5.2	5.4	5.6	2.4	2.3	-2.3
Mn content in liver	0.2	0.2	0.2	-0.3	-0.5	0.5
Na content in liver	0.2	0.2	0.5	0.7	0.3	-0.2
Rb content in liver	0.1	0.1	0.2	-0.2	0.3	-0.4
Se content in liver	1.8	2.2	3.5	1.9	1.3	-1.2
Sr content in liver	0.8	0.7	0.8	-0.7	-0.9	0.9
Zn content in liver	0.2	0.2	0.3	0.6	0.5	-0.4
Bone: minimum diameter	1.2	2.3	6.2	-2.5	-0.6	0.6
Time in familiar zone, hab. session 1	0.8	0.8	1.1	-0.4	-1.0	1.0
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.4	0.6	-0.6
Total zone transitions, hab. session 1	0.2	0.3	0.5	-0.7	-0.4	0.4
Total locomotion distance, hab. session 1	0.2	0.2	0.7	-0.8	0.0	-0.0
Locomotion velocity, hab. session 1	0.2	0.2	0.6	-0.7	0.2	-0.2
Time in familiar zone, hab. session 2	0.5	0.5	0.7	0.8	0.7	-0.7
Time in novel zone, hab. session 2	0.9	0.9	1.3	-1.1	-0.9	0.8
Total zone transitions, hab. session 2	0.5	0.6	1.0	-1.0	0.7	-0.7
Total locomotion distance, hab. session 2	0.8	1.1	1.6	-0.3	1.3	-1.3
Locomotion velocity, hab. session 2	0.7	1.0	1.4	-0.4	1.2	-1.2
Novel to familiar place preference ratio	1.3	1.3	1.4	-1.1	-1.2	1.2
Novelty place preference	1.4	1.5	1.5	-1.2	-1.2	1.2
Time in novel zone, NPP test	1.2	1.2	1.3	-1.1	-1.1	1.1
Total zone transitions, NPP test	1.1	1.6	2.4	0.2	1.5	-1.5
Total locomotion distance, NPP test	1.5	2.1	3.0	0.7	1.7	-1.7
Locomotion velocity, NPP test	1.1	1.6	2.3	0.6	1.5	-1.5
Intraocular pressure	1.4	2.0	2.7	1.0	1.6	-1.5
Delta distance traveled before/after self-admin	5.0	5.4	6.8	2.6	2.2	-2.2
Delta ambulatory time before/after self-admin	5.8	6.3	7.8	2.8	2.3	-2.4
Parametrial fat weight	0.5	0.9	2.4	1.6	0.4	-0.5
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.0	0.6	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. change in total contacts	0.8	0.9	1.3	-0.2	-1.1	1.2
Pavlov. Cond. index score	0.0	0.0	0.0	0.2	-0.1	0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	-0.2	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.0	-0.0
Pavlov. Cond. magazine entry number	0.4	0.6	0.8	0.1	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	0.5	1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	-0.3	0.2
Pavlov. Cond. response bias	0.3	0.3	0.5	0.1	-0.7	0.7
Pavlov. Cond. lever latency	0.8	1.1	1.4	-0.6	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.3	1.5	2.2	1.5	1.0	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. index score	0.9	1.2	1.7	1.3	0.9	-1.0
Pavlov. Cond. latency score	1.0	1.2	1.3	1.2	1.0	-1.1
Pavlov. Cond. lever contacts	1.4	2.0	2.6	0.9	1.6	-1.6
Pavlov. Cond. magazine entry number	1.5	1.9	3.5	-1.9	-0.9	1.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.7	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.1	1.4	1.0	-1.1
Pavlov. Cond. response bias	1.1	1.5	1.7	1.3	1.1	-1.2
Time in closed arm before self-admin	0.8	0.9	1.3	-0.6	-1.1	1.1
Time in closed arm after self-admin	1.3	1.3	2.0	0.3	-1.4	1.4
Time in open arm before self-admin	0.6	0.7	1.7	-1.3	0.3	-0.4
Time in open arm after self-admin	0.3	0.4	1.0	-1.0	0.1	-0.2
Bone: periosteal estimation	1.4	2.9	7.7	-2.8	-0.7	0.7
Bone: periosteal perimeter	3.3	5.4	10.0	-3.2	-1.8	1.7
Bone: post-yield work	0.1	0.1	0.4	-0.6	0.1	-0.1
Progressive ratio test 1 active lever presses	1.6	1.6	2.2	1.5	1.1	-1.2
Progressive ratio test 1 breakpoint	1.4	1.5	1.7	1.3	1.1	-1.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.9	0.9	0.4	-0.5
Progressive ratio test 2 active lever presses	0.6	0.7	1.2	1.1	0.6	-0.6
Progressive ratio test 2 breakpoint	0.9	1.0	1.4	1.2	0.9	-0.9
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	-0.4	0.3
Incentive Sensitization - Responses	0.5	0.5	0.5	0.7	0.7	-0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.6	0.6	-0.6
Sum of active levers in priming session hrs 5-6	1.2	1.1	1.7	1.3	-0.9	0.9
Progressive ratio	0.2	0.2	0.3	-0.3	-0.5	0.5
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.3	-0.1	0.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	0.3	0.6	-0.6
Retroperitoneal fat weight	1.1	3.6	4.1	1.8	1.8	-2.0
Reaction time number correct	2.1	3.1	4.8	0.2	2.1	-2.2
Reaction time mean minus median	0.3	0.4	1.2	1.1	0.2	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.3	0.5	0.2	-0.3
Reaction time num false alarms	0.2	0.2	0.4	-0.6	0.5	-0.3
Reaction time num false alarms AUC	0.2	0.2	0.3	-0.5	0.6	-0.4
Reaction time trials correct on left	2.1	3.1	4.8	0.2	2.1	-2.2
Reaction time trials on left	2.3	3.3	5.1	0.2	2.2	-2.3
Reaction time mean	0.2	0.3	0.4	0.4	0.6	-0.7
Reaction time mean AUC	0.4	0.6	0.9	0.2	0.9	-0.9
Median of all reaction times	0.1	0.2	0.3	-0.1	0.5	-0.5
Reaction time omissions	1.8	2.5	2.9	1.4	1.6	-1.7
Reaction time false alarm rate	0.3	0.4	0.5	-0.5	-0.6	0.7
Reaction time premature initiation rate	0.1	0.1	0.2	0.2	0.4	-0.1
Reaction time premature initiations	1.0	1.4	2.3	0.4	1.5	-1.3
Std. dev. reaction times	0.3	0.5	0.6	0.6	0.7	-0.8
Reaction time trials completed	2.3	3.3	5.1	0.2	2.2	-2.3
Reaction time trials AUC	2.2	3.1	4.8	0.1	2.1	-2.2
Run reversals in cocaine runway, females	0.4	0.4	0.7	-0.0	0.7	-0.8
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.6	-0.3	0.2
Latency to leave start box in cocaine runway	0.4	0.4	0.5	0.6	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.8	0.8	1.3	-0.2	1.1	-1.1
Latency to leave start box in cocaine runway, M	1.2	1.1	3.2	1.8	0.2	-0.2
Std. dev. time between licks in bursts	1.5	1.8	2.8	0.6	1.5	-1.7
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	-0.1	0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.3	0.6	-0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.7	0.8	-0.3	0.3
Short access day 1 total infusions	0.4	0.4	0.6	-0.4	-0.8	0.7
Short access day 10 total infusions	0.8	0.9	2.2	1.5	0.4	-0.5
Short access total infusions	0.1	0.2	0.5	0.7	0.1	-0.2
Short access day 1 locomotion	1.7	1.8	2.0	-1.4	-1.3	1.3
Short access day 10 total locomotion	0.9	1.0	1.6	-0.0	-1.2	1.2
Short access total locomotion	1.0	1.1	1.4	-0.8	-1.1	1.2
One hour access (0.3 mA shock)	0.9	1.0	1.6	1.3	0.8	-0.9
Compulsive drug intake	0.2	0.2	0.5	-0.7	-0.3	0.4
One hour access (shock baseline)	1.1	1.3	1.4	1.1	1.2	-1.2
Social response proportion	0.1	0.1	0.3	-0.1	-0.6	0.3
Social responses	0.2	0.3	0.6	-0.8	-0.4	0.2
Social time	0.9	1.2	2.6	-1.6	-0.8	0.7
Soleus weight	0.3	1.0	1.7	0.1	1.2	-1.3
Bone: stiffness	4.8	7.6	11.0	-3.3	-2.4	2.4
Tibialis anterior weight	0.5	1.6	2.2	0.6	1.5	-1.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.2	0.6	-0.5
Time to tail flick, vehicle, after self-admin	1.7	1.8	3.0	-1.7	-1.0	1.1
Time to tail flick, test, before self-admin	2.7	2.6	6.7	2.6	0.7	-0.7
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.7	-0.4	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.3	0.2	-0.2
Delta time to tail flick, test, before/after SA	4.2	3.8	4.3	-2.1	-1.9	1.9
Tibia length	6.8	19.3	32.0	-5.7	-3.8	3.4
Ambulatory time before self-admin	0.6	0.6	0.7	-0.6	-0.8	0.8
Ambulatory time after self-admin	2.4	2.7	3.5	1.9	1.5	-1.5
Bone: tissue strength	0.9	0.9	2.7	-1.6	0.1	-0.2
Total heroin consumption	5.9	6.9	8.0	-2.2	-2.8	2.8
Bone: trabecular number	0.1	0.1	0.3	-0.0	0.3	-0.5
Bone: trabecular spacing	1.2	1.6	2.0	0.9	1.4	-1.4
Bone: trabecular thickness	1.6	1.9	2.3	-1.0	-1.5	1.5
Bone: trabecular tissue density	0.1	0.2	0.3	0.2	-0.4	0.6
Water consumed over 24 hours	0.0	0.0	0.1	0.1	0.2	-0.2
Number of responses in last shaping day	0.5	0.5	0.8	-0.9	-0.7	0.6