Hub : Genes

Foxa3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_039101386.2 0.45 0.16 6.9e-05 0.01 0 0.01 0 7.1e-02 1.2e-01 2.8e-02 3.2e-01
2 IC gene expression Foxa3 0.11 0.1 4.1e-03 0.02 0.02 0 0.01 4.3e-02 6.5e-02 2.5e-01 7.6e-02
3 pVTA gene expression Foxa3 0.04 0.04 5.3e-03 0 -0 -0 -0 1.4e-01 5.3e-01 7.8e-01 4.9e-01
4 Brain gene expression Foxa3 0.09 0.09 3.6e-07 0.07 0.07 0.07 0.07 7.1e-07 7.1e-07 7.1e-07 6.7e-07
5 Liver mRNA stability Foxa3 0.12 0.09 2.4e-14 0.12 0.12 0.12 0.12 6.6e-13 4.4e-13 9.2e-13 9.4e-13
6 Liver isoform ratio NM_017077.2 0.47 0.15 2.8e-05 0 0 0.01 -0 2.7e-01 2.0e-01 1.2e-02 9.0e-01
7 NAcc gene expression Foxa3 0.03 0.02 2.4e-04 0.02 0.02 0.02 0.02 5.4e-04 8.5e-04 7.9e-04 1.0e-03
8 Adipose gene expression Foxa3 0.08 0.06 1.7e-08 0.07 0.07 0.08 0.07 2.6e-08 1.3e-08 2.1e-09 2.5e-08
9 PL gene expression Foxa3 0.39 0.21 2.0e-05 0.03 0.03 0.02 0.03 4.3e-04 1.4e-04 4.6e-03 6.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.10.20.10.1-0.10.0-0.1-0.1-0.20.3
Area under the delay curve1.11.63.1-0.9-1.3-1.31.4-1.30.8-1.4-1.11.7
BMI with tail0.72.65.62.31.61.6-1.41.6-2.41.31.20.2
BMI without tail0.63.27.72.71.61.6-1.31.7-2.81.31.30.6
Body weight1.46.111.53.42.52.5-2.22.5-3.42.22.0-0.1
Weight adjusted by age0.00.10.40.5-0.0-0.00.00.1-0.60.10.20.3
Bone surface0.20.40.80.90.60.6-0.70.7-0.90.60.50.1
Bone volume0.10.30.40.70.60.6-0.60.5-0.60.50.4-0.1
Breakpoint value in progressive ratio session1.73.16.5-2.4-1.5-1.51.7-1.72.6-1.6-1.50.8
Number of licking bursts1.23.64.41.62.12.1-1.92.0-1.42.11.9-1.9
Context. condit. distance diff. score0.10.10.60.10.20.2-0.40.3-0.00.30.3-0.8
Locomotion velocity, session 10.10.20.5-0.6-0.2-0.20.2-0.30.7-0.3-0.2-0.5
Locomotion distance, session 10.00.10.3-0.1-0.0-0.0-0.40.00.00.10.2-0.6
Locomotion velocity, session 21.31.62.31.51.21.2-1.11.3-1.51.31.2-0.7
Locomotion distance, session 20.20.30.70.70.40.4-0.70.5-0.80.50.6-0.2
Locomotion velocity, session 30.30.30.90.90.40.4-0.40.5-0.90.50.50.1
Locomotion distance, session 30.70.81.6-0.3-1.1-1.11.0-0.90.0-0.9-0.81.3
Stereotopy head waving bouts, day 30.91.01.40.81.21.2-0.91.1-0.61.11.0-1.1
Stereotopy head waving duration, day 30.91.12.20.51.11.1-1.11.1-0.31.21.0-1.5
Locomotion velocity, session 70.20.20.3-0.5-0.5-0.50.5-0.50.3-0.4-0.40.3
Locomotion distance, session 70.10.10.40.50.10.1-0.10.1-0.60.20.20.5
Stereotopy head waving bouts, day 70.91.12.70.41.21.2-1.01.1-0.01.00.8-1.6
Stereotopy head waving duration, day 70.70.91.90.51.11.1-0.91.0-0.21.00.8-1.4
Locomotion velocity, session 80.00.00.10.2-0.2-0.20.0-0.1-0.4-0.00.1-0.0
Locomotion distance, session 80.00.00.10.3-0.1-0.1-0.20.0-0.4-0.00.1-0.0
Degree of sensitization distance0.50.50.80.60.90.9-0.80.8-0.50.80.7-0.5
Degree of sensitization stereotypy1.01.12.40.51.31.3-1.01.1-0.21.00.8-1.5
Conditioned locomotion0.00.00.1-0.2-0.2-0.20.2-0.20.1-0.2-0.20.1
Cocaine response after cond. corrected0.40.60.90.40.90.9-0.90.8-0.30.80.7-1.0
Cocaine response after cond. not corrected1.01.41.80.91.41.4-1.31.2-0.71.31.1-1.2
Cocaine response before conditioning1.41.72.21.31.51.5-1.31.4-1.11.31.2-1.1
Saline control response1.82.42.91.41.61.6-1.71.6-1.31.71.5-1.5
Bone: connectivity density0.10.10.60.2-0.2-0.20.0-0.2-0.2-0.3-0.20.8
Bone: cortical apparent density0.00.10.2-0.1-0.1-0.10.4-0.30.2-0.4-0.40.2
Bone: cortical area1.32.22.51.51.61.6-1.51.6-1.41.61.4-1.0
Bone: cortical porosity0.10.10.3-0.3-0.4-0.40.6-0.40.2-0.3-0.30.4
Bone: cortical porosity0.00.00.10.10.10.10.20.1-0.10.00.00.2
Bone: cortical thickness0.50.91.10.91.01.0-1.01.0-0.81.00.9-0.8
Bone: cortical thickness1.31.51.91.21.31.3-1.41.3-1.01.31.1-1.3
Bone: cortical tissue density0.10.10.3-0.2-0.2-0.20.5-0.40.3-0.5-0.60.3
Condit. Reinf. active minus inactive responses0.40.40.80.80.90.9-0.40.7-0.60.50.5-0.0
Condit. Reinf. active-inactive response ratio0.30.30.50.70.70.7-0.40.6-0.50.30.30.0
Condit. Reinf. active responses0.20.30.50.70.70.7-0.30.6-0.60.40.30.1
Condit. Reinf. inactive responses0.10.10.1-0.2-0.4-0.40.1-0.30.1-0.3-0.20.2
Incentive salience index mean0.30.40.80.90.80.8-0.20.7-0.70.40.40.3
Condit. Reinf. lever presses0.10.20.40.60.30.30.10.3-0.60.00.10.7
Condit. Reinf. active minus inactive responses0.00.10.20.10.20.2-0.30.3-0.10.30.2-0.5
Condit. Reinf. active-inactive response ratio0.20.31.00.10.40.4-0.80.5-0.10.60.5-1.0
Condit. Reinf. active responses0.10.10.1-0.3-0.3-0.30.3-0.30.3-0.3-0.30.1
Condit. Reinf. inactive responses0.50.71.0-0.7-0.8-0.81.0-0.90.7-1.0-0.90.7
Condit. Reinf. lever presses0.10.20.50.60.30.3-0.50.4-0.70.40.4-0.1
Condit. Reinf. lever reinforcers received0.10.10.1-0.4-0.4-0.40.3-0.30.3-0.3-0.30.1
Conditioned reinforcement - actives0.62.33.41.81.61.6-1.51.6-1.81.41.4-0.3
Conditioned reinforcement - inactives0.51.33.81.80.80.8-0.71.0-1.90.80.80.8
Conditioned locomotion1.72.54.01.11.71.7-1.81.6-0.81.71.5-2.0
Patch foraging indifference point 0 sec0.20.72.10.40.70.7-1.00.8-0.30.90.7-1.4
Patch foraging indifference point AUC2.04.76.32.52.22.2-2.12.3-2.52.22.0-1.0
Delay disc. indifference point, 0s delay1.11.33.4-0.7-1.0-1.01.2-1.00.7-1.2-0.91.9
Delay disc. indifference point, 16s delay0.81.12.8-0.2-1.1-1.11.1-1.0-0.0-1.1-1.01.7
Delay disc. indifference point, 2s delay2.73.06.0-0.7-1.9-1.92.0-1.80.4-1.9-1.62.5
Delay disc. indifference point, 24s delay0.00.10.20.20.10.1-0.30.1-0.10.20.1-0.5
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.0-0.00.00.00.20.00.20.3
Delay disc. indifference point, 8s delay1.11.82.5-1.6-1.2-1.21.4-1.31.6-1.4-1.11.2
Indifference point function ln k0.72.14.4-2.0-1.4-1.41.1-1.42.1-1.2-1.3-0.3
Indifference point function log k0.72.14.4-2.0-1.4-1.41.1-1.42.1-1.2-1.3-0.3
Patch foraging total patch changes 0 sec0.41.03.00.40.80.8-1.30.9-0.31.10.9-1.7
Patch foraging total patch changes 12 sec1.72.34.22.01.51.5-1.31.5-2.11.41.3-0.4
Patch foraging total patch changes 18 sec1.22.83.91.31.81.8-2.01.7-1.11.71.6-1.9
Patch foraging total patch changes 24 sec0.20.81.41.20.90.9-0.90.8-1.20.70.7-0.3
Patch foraging total patch changes 6 sec2.03.44.71.71.91.9-2.21.9-1.61.91.7-1.7
Patch foraging time to switch 0 sec1.14.46.2-1.8-2.0-2.02.5-2.11.7-2.3-1.92.4
Patch foraging water rate 0 sec1.35.07.01.92.22.2-2.62.4-1.72.42.1-2.5
Patch foraging water rate 12 sec0.10.20.40.50.40.4-0.60.4-0.50.40.4-0.6
Patch foraging water rate 18 sec0.10.20.40.60.10.1-0.70.3-0.70.40.4-0.3
Patch foraging water rate 24 sec0.50.82.40.20.80.8-1.10.70.00.90.7-1.6
Patch foraging water rate 6 sec0.50.81.31.00.70.7-1.10.9-1.00.90.8-0.8
Seeking ratio, delayed vs. immediate footshock1.52.12.5-1.5-1.5-1.51.6-1.61.5-1.6-1.50.8
Distance traveled before self-admin0.00.10.20.2-0.0-0.0-0.40.2-0.20.30.3-0.3
Distance traveled after self-admin0.10.20.5-0.3-0.7-0.70.4-0.50.0-0.4-0.40.2
Extensor digitorum longus weight1.76.68.02.62.82.8-2.72.7-2.32.72.5-1.7
Bone: elastic displacement0.81.01.4-1.0-0.7-0.71.2-1.01.2-1.2-1.10.8
Bone: elastic work0.10.10.10.40.40.4-0.10.2-0.20.10.10.3
Bone: endosteal estimation0.10.21.20.3-0.2-0.20.4-0.2-0.5-0.3-0.21.1
Bone: endosteal perimeter0.00.10.40.4-0.0-0.00.20.0-0.5-0.10.00.7
Epididymis fat weight0.10.61.6-0.2-0.6-0.60.9-0.70.1-0.9-0.71.3
Delta time in closed arm before/after self-admin0.20.20.4-0.6-0.4-0.40.3-0.50.6-0.4-0.4-0.6
Delta time in open arm before/after self-admin0.30.31.10.80.00.00.00.0-1.1-0.1-0.11.1
Diff in mean of infusions in LGA sessions1.12.04.6-2.0-1.1-1.11.3-1.32.2-1.3-1.20.3
Delay discount exponential model param0.81.12.00.81.21.2-1.11.1-0.71.10.9-1.4
Extinction: sum of active levers before priming0.10.10.5-0.50.10.10.3-0.20.7-0.2-0.10.4
Active lever presses in extinction session 60.20.20.5-0.40.40.4-0.20.40.70.20.30.5
Bone: final force0.40.71.11.10.90.9-0.80.8-1.00.80.8-0.2
Bone: final moment0.61.01.61.21.11.1-0.91.0-1.21.00.9-0.2
Food consumed during 24 hour testing period3.06.17.6-2.3-2.6-2.62.6-2.72.1-2.8-2.42.0
Glucose0.30.51.2-1.1-0.6-0.60.7-0.71.1-0.6-0.5-0.2
Heart weight1.72.73.61.31.71.7-1.81.8-1.11.91.6-1.8
Delay discount hyperbolic model param0.81.01.90.71.11.1-1.11.0-0.71.00.8-1.4
Intermittent access intake day 1-15 change0.00.20.20.30.50.5-0.50.4-0.20.40.5-0.0
Intermittent access intake escalation0.00.30.30.50.60.6-0.50.5-0.50.50.60.1
Intermittent access intake escalation 20.10.20.7-0.70.00.0-0.1-0.00.90.10.2-0.5
Intermitt. access day 1 inactive lever presses0.00.20.80.80.10.1-0.00.2-0.90.10.20.7
Intermitt. access day 15 inactive lever presses0.00.10.30.50.00.0-0.00.1-0.60.00.10.2
Intermitt. access escalation Index0.10.20.4-0.4-0.4-0.40.6-0.50.3-0.6-0.60.1
Intermittent access day 1 total infusions0.92.64.42.11.61.6-1.61.7-2.01.51.5-0.2
Intermittent access day 15 total infusions0.51.31.81.31.31.3-1.11.2-1.21.11.0-0.3
Intermittent access terminal intake (last 3 days)0.81.52.21.11.51.5-1.31.3-0.91.21.2-0.8
Intermittent access total infusions2.52.94.11.72.02.0-1.81.8-1.51.71.6-1.1
Intermittent access day 1 locomotion0.30.61.61.20.60.6-0.60.7-1.30.60.60.1
Intermittent access day 15 total locomotion0.10.30.60.70.40.4-0.50.5-0.80.50.5-0.1
Intermittent access total locomotion1.61.92.61.61.41.4-1.51.5-1.61.41.3-0.8
Intermittent access standard deviation0.00.20.3-0.6-0.4-0.40.4-0.50.5-0.4-0.40.2
Left kidney weight2.923.628.45.35.05.0-5.25.2-5.15.04.5-3.0
Right kidney weight3.020.724.24.64.94.9-4.94.9-4.24.84.3-3.2
Cocaine induced anxiety0.10.31.00.2-0.4-0.40.6-0.3-0.2-0.5-0.41.0
Post-drug Anxiety0.00.00.1-0.1-0.1-0.10.3-0.10.2-0.1-0.20.1
Baseline Anxiety0.60.93.2-1.50.00.0-0.0-0.31.70.1-0.2-1.8
Tail length0.31.83.71.91.31.3-1.21.4-1.81.11.20.3
Length with tail0.41.73.21.81.31.3-1.31.4-1.71.11.10.1
Length without tail0.21.01.51.01.21.2-1.21.1-0.91.00.9-0.6
Times rat made contact with spout0.10.10.2-0.4-0.3-0.3-0.0-0.20.4-0.2-0.2-0.4
Lifetime Intake2.53.14.32.02.12.1-1.71.8-1.81.71.5-0.9
Liver weight, left1.93.34.01.91.91.9-1.92.0-1.71.91.7-1.2
Liver weight, right1.52.64.42.11.81.8-1.51.7-1.91.31.2-0.3
Locomotor activity1.82.83.91.21.71.7-1.81.8-0.92.01.7-1.9
Locomotor testing distance0.71.82.41.31.31.3-1.51.5-1.31.51.5-0.8
Locomotor testing rearing2.17.79.22.82.92.9-2.93.0-2.63.02.7-1.9
Locomotion in novel chamber0.40.61.8-1.3-0.5-0.50.4-0.61.3-0.3-0.5-0.8
Locomotion in novel chamber post-restriction0.51.41.7-1.3-1.3-1.31.1-1.21.1-1.3-1.01.1
Fecal boli incidents, locomotor time 10.00.00.1-0.00.10.1-0.20.30.20.20.30.3
Change in fecal boli incidents, locomotor task0.50.61.4-0.3-0.7-0.70.9-0.80.2-0.9-0.71.2
Time >=10cm from walls, locomotor time 10.00.00.1-0.2-0.1-0.1-0.1-0.00.3-0.1-0.10.3
Bouts of movement, locomotor time 11.72.22.8-1.2-1.6-1.61.6-1.71.0-1.7-1.51.1
Total resting periods, locomotor time 12.42.83.6-1.3-1.8-1.81.8-1.91.1-1.9-1.71.4
Rest time, locomotor task time 10.10.20.3-0.1-0.5-0.50.5-0.5-0.1-0.5-0.40.5
Distance moved, locomotor task time 10.20.50.70.40.80.8-0.70.8-0.20.80.7-0.7
Vertical activity count, locomotor time 10.00.10.60.40.10.10.10.1-0.4-0.0-0.00.8
Time >=10cm from walls, locomotor time 20.10.20.50.5-0.3-0.30.3-0.2-0.7-0.2-0.10.6
Bouts of movement, locomotor time 22.27.29.9-3.1-2.8-2.82.7-2.83.1-2.7-2.41.3
Total resting periods, locomotor time 21.66.610.0-3.2-2.6-2.62.5-2.73.1-2.5-2.31.0
Rest time, locomotor task time 20.10.10.3-0.5-0.2-0.20.1-0.30.5-0.3-0.4-0.5
Distance moved, locomotor task time 20.91.22.51.51.01.0-0.91.0-1.61.01.0-0.5
Vertical activity count, locomotor time 20.10.31.90.5-0.1-0.10.3-0.1-0.5-0.2-0.11.4
Light reinforcement 10.00.10.20.40.20.2-0.40.3-0.40.30.20.0
Light reinforcement 20.30.72.41.30.30.3-0.30.5-1.60.30.41.2
Bone: marrow area0.10.21.00.4-0.1-0.10.3-0.1-0.5-0.2-0.11.0
Bone: maximum diameter1.93.84.72.12.22.2-1.92.1-2.02.01.8-1.3
Bone: maximum force0.20.30.50.70.60.6-0.60.6-0.70.60.60.1
Bone: maximum moment0.30.50.80.90.70.7-0.70.7-0.90.70.70.2
Mean time between licks in bursts0.00.00.20.1-0.1-0.10.1-0.2-0.1-0.3-0.30.4
Mean num. licks in bursts1.54.05.2-1.9-2.3-2.31.9-2.21.7-2.2-2.01.5
Cd content in liver0.30.41.4-1.0-0.3-0.30.2-0.41.2-0.2-0.3-0.6
Co content in liver1.01.21.5-1.2-1.0-1.01.2-1.21.2-1.2-1.10.6
Cu content in liver0.40.40.60.60.80.8-0.70.7-0.50.60.6-0.5
Fe content in liver4.45.58.41.72.52.5-2.52.4-1.42.52.2-2.9
K content in liver0.50.51.51.10.40.4-0.40.5-1.20.40.50.6
Mg content in liver0.80.92.21.40.80.8-0.70.9-1.50.70.80.1
Mn content in liver1.11.22.31.51.11.1-1.01.1-1.51.00.9-0.2
Na content in liver0.20.21.00.00.30.3-0.50.40.10.70.4-1.0
Rb content in liver0.10.10.10.30.20.2-0.30.2-0.30.20.3-0.1
Se content in liver3.64.35.22.12.32.3-2.12.3-1.92.22.0-1.5
Sr content in liver0.10.00.10.20.20.2-0.20.2-0.20.30.2-0.1
Zn content in liver0.70.81.01.01.01.0-1.01.0-0.81.01.0-0.1
Bone: minimum diameter0.20.30.60.80.50.5-0.60.6-0.80.60.60.0
Time in familiar zone, hab. session 10.10.10.20.20.30.3-0.30.4-0.30.50.4-0.5
Time in novel zone, hab. session 10.50.60.80.70.90.9-0.80.8-0.50.80.7-0.6
Total zone transitions, hab. session 10.10.10.40.20.30.3-0.50.4-0.20.40.4-0.6
Total locomotion distance, hab. session 10.30.40.6-0.5-0.7-0.70.7-0.70.3-0.7-0.60.6
Locomotion velocity, hab. session 11.01.41.8-0.9-1.3-1.31.2-1.30.7-1.3-1.21.2
Time in familiar zone, hab. session 20.20.30.40.30.60.6-0.60.6-0.10.50.5-0.5
Time in novel zone, hab. session 20.10.20.3-0.6-0.5-0.50.2-0.40.5-0.2-0.2-0.3
Total zone transitions, hab. session 20.40.51.00.60.80.8-0.70.8-0.50.80.7-1.0
Total locomotion distance, hab. session 20.40.60.8-0.6-0.8-0.80.9-0.80.5-0.8-0.80.5
Locomotion velocity, hab. session 20.30.40.5-0.2-0.7-0.70.7-0.60.1-0.7-0.60.6
Novel to familiar place preference ratio0.30.40.80.70.50.5-0.90.6-0.80.70.7-0.4
Novelty place preference0.30.40.70.60.40.4-0.80.6-0.80.70.7-0.4
Time in novel zone, NPP test0.40.50.80.60.50.5-0.90.7-0.70.80.8-0.6
Total zone transitions, NPP test0.10.20.20.40.30.3-0.40.3-0.40.40.4-0.4
Total locomotion distance, NPP test0.10.10.50.10.30.3-0.40.3-0.10.40.3-0.7
Locomotion velocity, NPP test0.10.10.20.20.20.2-0.30.2-0.20.30.3-0.5
Intraocular pressure0.30.41.6-1.10.00.00.1-0.21.3-0.0-0.1-1.1
Delta distance traveled before/after self-admin1.51.74.8-0.2-1.3-1.31.5-1.2-0.1-1.4-1.22.2
Delta ambulatory time before/after self-admin0.30.51.30.2-0.7-0.70.7-0.6-0.4-0.7-0.61.1
Parametrial fat weight0.10.20.50.70.40.4-0.30.4-0.70.50.30.0
Pavlov. Cond. lever latency0.40.50.7-0.7-0.8-0.80.6-0.80.5-0.7-0.60.6
Pavlov. Cond. magazine entry latency0.10.10.20.50.40.4-0.20.4-0.30.20.1-0.0
Pavlov. Cond. change in total contacts0.60.60.9-0.8-0.7-0.70.9-0.80.8-0.9-0.80.7
Pavlov. Cond. index score0.20.20.40.50.60.6-0.40.6-0.30.50.4-0.4
Pavlov. Cond. latency score0.00.00.10.30.30.3-0.00.3-0.10.20.1-0.2
Pavlov. Cond. lever contacts0.30.30.50.60.70.7-0.50.7-0.50.50.4-0.4
Pavlov. Cond. magazine entry number0.00.00.1-0.2-0.3-0.3-0.0-0.20.00.00.00.0
Pavlov. Cond. intertrial magazine entries0.10.10.20.00.40.4-0.30.2-0.10.30.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.50.60.6-0.40.6-0.30.50.4-0.5
Pavlov. Cond. response bias0.70.91.21.11.11.1-0.91.1-0.80.90.8-0.6
Pavlov. Cond. lever latency0.00.00.0-0.2-0.2-0.20.2-0.10.2-0.2-0.2-0.1
Pavlov. Cond. magazine entry latency0.00.00.10.20.10.1-0.10.1-0.20.00.00.1
Pavlov. Cond. change in total contacts0.10.30.5-0.7-0.7-0.70.3-0.60.6-0.5-0.50.1
Pavlov. Cond. index score0.00.00.10.0-0.2-0.20.0-0.2-0.1-0.2-0.10.4
Pavlov. Cond. latency score0.00.10.2-0.1-0.3-0.30.1-0.3-0.0-0.3-0.20.5
Pavlov. Cond. lever contacts0.10.10.20.40.30.3-0.30.3-0.50.30.30.1
Pavlov. Cond. magazine entry number0.30.30.60.50.60.6-0.60.6-0.30.70.5-0.8
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.30.00.0-0.20.00.40.10.1-0.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.00.0-0.20.0-0.3-0.00.00.2
Pavlov. Cond. response bias0.00.00.10.1-0.0-0.00.0-0.0-0.1-0.1-0.10.3
Time in closed arm before self-admin0.40.81.40.10.90.9-1.21.00.11.01.0-1.0
Time in closed arm after self-admin1.11.22.8-1.6-1.1-1.10.9-1.11.7-0.9-0.9-0.1
Time in open arm before self-admin0.60.81.5-0.5-0.9-0.91.2-0.90.4-0.9-0.91.0
Time in open arm after self-admin0.40.41.60.7-0.1-0.10.5-0.2-1.0-0.3-0.21.3
Bone: periosteal estimation0.30.61.41.10.80.8-0.60.8-1.20.70.70.2
Bone: periosteal perimeter0.30.61.61.20.70.7-0.50.8-1.30.60.70.2
Bone: post-yield work0.61.02.8-0.4-1.1-1.10.9-1.00.2-1.1-0.81.7
Progressive ratio test 1 active lever presses2.03.55.32.32.02.0-1.82.0-2.31.81.7-0.5
Progressive ratio test 1 breakpoint2.03.45.72.41.91.9-1.71.9-2.41.71.6-0.2
Progressive ratio test 1 inactive lever presses0.71.93.31.81.11.1-1.41.5-1.81.41.4-0.1
Progressive ratio test 2 active lever presses2.12.94.01.92.02.0-1.61.8-1.81.71.5-0.6
Progressive ratio test 2 breakpoint2.53.24.42.02.12.1-1.71.9-1.91.71.6-0.7
Progressive ratio test 2 inactive lever presses0.31.02.81.60.70.7-0.40.7-1.70.50.61.2
Incentive Sensitization - Responses0.61.72.51.41.61.6-1.21.4-1.21.31.1-0.6
Incentive Sensitization - Breakpoint0.71.52.21.31.51.5-1.11.3-1.11.21.1-0.6
Sum of active levers in priming session hrs 5-60.90.93.8-1.6-0.2-0.20.6-0.51.9-0.5-0.5-0.3
Progressive ratio0.41.32.0-1.0-1.1-1.11.4-1.20.8-1.4-1.20.8
Food seeking constrained by brief footshock5.46.89.1-3.0-2.6-2.62.5-2.63.0-2.5-2.32.2
Seeking ratio, punishment vs. effort0.51.11.6-1.2-1.1-1.10.8-0.91.2-0.8-0.71.3
Retroperitoneal fat weight0.00.10.20.50.40.4-0.20.4-0.40.40.3-0.1
Reaction time number correct1.86.310.91.62.62.6-3.02.6-1.22.82.3-3.3
Reaction time mean minus median0.11.02.9-1.6-0.5-0.50.4-0.71.7-0.3-0.4-1.3
Reaction time mean minus median AUC0.10.73.4-1.00.30.3-0.30.11.20.40.2-1.8
Reaction time num false alarms3.86.49.33.02.72.7-2.52.6-2.92.42.2-1.3
Reaction time num false alarms AUC2.55.78.93.02.52.5-2.32.5-2.92.32.0-1.0
Reaction time trials correct on left1.86.310.91.62.62.6-3.02.6-1.22.82.3-3.3
Reaction time trials on left1.86.310.41.62.62.6-3.02.6-1.22.82.3-3.2
Reaction time mean0.92.03.2-1.8-1.3-1.31.5-1.51.7-1.4-1.30.7
Reaction time mean AUC0.71.62.8-1.7-1.1-1.11.3-1.31.6-1.2-1.10.5
Median of all reaction times1.42.12.7-1.5-1.3-1.31.7-1.51.4-1.6-1.41.4
Reaction time omissions0.00.00.30.10.20.20.00.10.0-0.10.10.5
Reaction time false alarm rate0.50.72.51.50.70.7-0.30.6-1.60.30.40.8
Reaction time premature initiation rate0.50.71.9-0.1-1.0-1.00.9-0.7-0.1-0.9-0.81.4
Reaction time premature initiations0.10.30.50.50.30.3-0.70.5-0.50.60.5-0.5
Std. dev. reaction times0.20.82.2-1.4-0.6-0.60.6-0.81.5-0.5-0.6-0.7
Reaction time trials completed1.86.310.41.62.62.6-3.02.6-1.22.82.3-3.2
Reaction time trials AUC2.27.611.81.82.82.8-3.32.9-1.43.12.6-3.4
Run reversals in cocaine runway, females0.30.30.50.1-0.7-0.70.5-0.5-0.4-0.5-0.50.6
Run reversals in cocaine runway, males0.40.40.50.50.70.7-0.70.7-0.40.70.6-0.7
Latency to leave start box in cocaine runway0.10.10.7-0.4-0.1-0.1-0.4-0.00.30.10.2-0.8
Latency to leave start box in cocaine runway, F0.50.62.3-0.10.50.5-1.00.60.10.80.8-1.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.3-0.5-0.50.3-0.40.2-0.4-0.40.3
Std. dev. time between licks in bursts0.10.10.30.60.30.3-0.20.2-0.6-0.00.00.5
Total sessions with >9 infusions3.54.45.62.02.42.4-2.22.2-1.82.11.9-1.8
Short access day 1 total inactive lever presses1.32.68.62.71.11.1-0.81.1-2.90.80.91.3
Short access day 10 total inactive lever presses0.21.11.6-0.8-1.1-1.11.2-1.10.7-1.1-1.01.1
Short access day 1 total infusions1.42.93.81.91.91.9-1.61.7-1.81.61.3-1.2
Short access day 10 total infusions2.84.75.92.42.42.4-2.22.3-2.32.11.9-1.3
Short access total infusions2.23.14.22.12.02.0-1.71.8-2.01.71.5-0.9
Short access day 1 locomotion2.54.26.02.52.22.2-2.12.2-2.32.01.8-1.0
Short access day 10 total locomotion0.00.00.3-0.1-0.0-0.0-0.1-0.00.10.0-0.0-0.5
Short access total locomotion0.71.01.71.31.01.0-1.01.0-1.30.90.8-0.5
One hour access (0.3 mA shock)0.10.10.20.40.40.4-0.20.2-0.40.20.20.2
Compulsive drug intake0.20.21.00.20.30.3-0.60.3-0.20.50.4-1.0
One hour access (shock baseline)0.61.42.01.31.41.4-1.21.3-1.21.11.1-0.4
Social response proportion0.60.81.60.50.80.8-1.10.9-0.41.00.8-1.2
Social responses0.70.91.11.00.90.9-1.01.0-1.01.00.9-0.8
Social time2.74.36.2-1.4-2.4-2.42.1-2.11.1-2.1-1.92.5
Soleus weight0.10.30.50.70.60.6-0.60.6-0.60.60.5-0.3
Bone: stiffness0.71.21.61.21.01.0-1.21.1-1.21.31.2-0.5
Tibialis anterior weight2.910.111.53.43.33.3-3.43.4-3.13.33.1-1.9
Time to tail flick, vehicle, before self-admin2.12.63.21.41.71.7-1.71.7-1.21.81.4-1.8
Time to tail flick, vehicle, after self-admin0.10.21.4-0.6-0.1-0.1-0.1-0.10.60.2-0.0-1.2
Time to tail flick, test, before self-admin0.30.40.6-0.7-0.2-0.20.7-0.60.8-0.7-0.60.5
Time to tail flick, test, after self-admin0.20.20.90.3-0.4-0.40.5-0.3-0.4-0.4-0.51.0
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.6-0.4-0.40.3-0.50.6-0.3-0.3-0.3
Delta time to tail flick, test, before/after SA0.70.91.91.20.60.6-1.00.9-1.41.00.8-0.4
Tibia length0.30.92.11.40.90.9-0.70.9-1.50.60.70.2
Ambulatory time before self-admin0.00.00.1-0.3-0.2-0.2-0.0-0.10.3-0.0-0.1-0.1
Ambulatory time after self-admin0.30.50.9-0.7-1.0-1.00.7-0.80.5-0.7-0.70.2
Bone: tissue strength0.80.80.9-0.9-1.0-1.00.9-0.90.8-0.9-0.80.9
Total heroin consumption0.00.10.3-0.20.00.00.10.00.3-0.1-0.00.6
Bone: trabecular number0.00.10.2-0.0-0.1-0.10.2-0.20.1-0.3-0.40.4
Bone: trabecular spacing0.00.10.2-0.20.10.1-0.20.20.30.30.3-0.5
Bone: trabecular thickness1.21.72.21.31.51.5-1.41.3-1.21.31.1-1.1
Bone: trabecular tissue density0.20.40.70.60.60.6-0.60.7-0.50.60.5-0.8
Water consumed over 24 hours0.10.20.3-0.6-0.4-0.40.3-0.50.6-0.5-0.5-0.1
Number of responses in last shaping day2.53.35.11.12.32.3-1.91.8-0.81.81.5-2.3