Hub : Genes

Foxa3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_039101386.2 0.45 0.16 6.9e-05 0.01 0 0.01 -0 7.1e-02 1.2e-01 2.3e-02 4.0e-01
2 IC gene expression Foxa3 0.11 0.1 4.1e-03 0.02 0.02 0 0.01 4.3e-02 6.5e-02 2.5e-01 7.7e-02
3 pVTA gene expression Foxa3 0.04 0.04 5.3e-03 0 -0 -0 -0 1.4e-01 5.3e-01 7.8e-01 4.8e-01
4 Brain gene expression Foxa3 0.09 0.09 3.6e-07 0.07 0.07 0.07 0.07 7.1e-07 7.1e-07 7.1e-07 6.8e-07
5 Liver mRNA stability Foxa3 0.12 0.09 2.4e-14 0.12 0.12 0.12 0.12 6.6e-13 4.4e-13 9.2e-13 9.2e-13
6 Liver isoform ratio NM_017077.2 0.47 0.15 2.8e-05 0 0 0.01 -0 2.7e-01 2.0e-01 1.2e-02 8.7e-01
7 NAcc gene expression Foxa3 0.03 0.02 2.4e-04 0.02 0.02 0.02 0.02 5.4e-04 8.5e-04 7.9e-04 1.0e-03
8 Adipose gene expression Foxa3 0.08 0.06 1.7e-08 0.07 0.07 0.08 0.07 2.6e-08 1.3e-08 2.1e-09 2.5e-08
9 PL gene expression Foxa3 0.39 0.21 2.0e-05 0.03 0.03 0.02 0.03 4.3e-04 1.4e-04 4.6e-03 5.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.1-0.2-0.1-0.1-0.10.00.10.10.20.3
Area under the delay curve1.41.63.10.81.31.31.4-1.3-0.81.41.11.7
BMI with tail0.82.65.6-2.4-1.6-1.6-1.41.62.3-1.3-1.20.2
BMI without tail1.13.27.8-2.8-1.6-1.6-1.31.72.7-1.3-1.30.6
Body weight1.46.212.0-3.5-2.5-2.5-2.22.53.4-2.2-2.0-0.1
Weight adjusted by age0.10.10.4-0.60.00.00.00.10.6-0.1-0.20.3
Bone surface0.20.40.8-0.9-0.6-0.6-0.70.70.8-0.6-0.50.1
Bone volume0.20.30.5-0.7-0.6-0.6-0.60.50.6-0.5-0.4-0.1
Breakpoint value in progressive ratio session2.63.16.52.41.51.51.7-1.7-2.61.61.50.8
Number of licking bursts2.23.64.4-1.6-2.1-2.1-1.92.01.4-2.1-1.9-1.9
Context. condit. distance diff. score0.10.10.6-0.0-0.2-0.2-0.40.30.0-0.3-0.3-0.8
Locomotion velocity, session 10.10.20.50.60.20.20.2-0.3-0.70.30.2-0.5
Locomotion distance, session 10.00.10.30.10.00.0-0.40.0-0.0-0.1-0.2-0.6
Locomotion velocity, session 21.31.62.3-1.5-1.2-1.2-1.11.31.5-1.3-1.2-0.7
Locomotion distance, session 20.20.30.7-0.7-0.4-0.4-0.70.50.8-0.5-0.6-0.2
Locomotion velocity, session 30.30.30.8-0.9-0.4-0.4-0.40.50.9-0.5-0.50.1
Locomotion distance, session 30.80.81.60.31.11.11.0-0.9-0.00.90.71.3
Stereotopy head waving bouts, day 30.91.01.4-0.8-1.2-1.2-0.91.10.6-1.1-1.0-1.1
Stereotopy head waving duration, day 30.91.12.2-0.5-1.1-1.1-1.11.10.4-1.2-1.0-1.5
Locomotion velocity, session 70.20.20.30.40.50.50.5-0.5-0.40.40.40.3
Locomotion distance, session 70.10.10.4-0.5-0.1-0.1-0.10.10.7-0.2-0.20.5
Stereotopy head waving bouts, day 70.91.12.7-0.4-1.2-1.2-1.01.10.0-1.0-0.8-1.6
Stereotopy head waving duration, day 70.70.91.9-0.5-1.1-1.1-0.91.00.2-1.0-0.8-1.4
Locomotion velocity, session 80.00.00.1-0.20.20.20.0-0.10.40.0-0.1-0.0
Locomotion distance, session 80.00.00.1-0.30.10.1-0.20.00.40.0-0.1-0.0
Degree of sensitization distance0.50.50.8-0.6-0.9-0.9-0.80.80.5-0.8-0.7-0.5
Degree of sensitization stereotypy1.01.12.4-0.5-1.3-1.3-1.01.10.2-1.0-0.8-1.5
Conditioned locomotion0.00.00.10.20.20.20.2-0.2-0.10.20.20.1
Cocaine response after cond. corrected0.50.60.9-0.4-0.9-0.9-0.90.80.3-0.8-0.7-1.0
Cocaine response after cond. not corrected1.21.41.8-0.9-1.4-1.4-1.31.20.7-1.3-1.1-1.2
Cocaine response before conditioning1.41.72.2-1.3-1.5-1.5-1.31.41.1-1.3-1.2-1.1
Saline control response1.82.42.9-1.4-1.6-1.6-1.71.61.4-1.7-1.5-1.5
Bone: connectivity density0.10.10.6-0.20.20.20.0-0.20.10.30.20.8
Bone: cortical apparent density0.10.10.20.10.10.10.4-0.3-0.20.40.50.2
Bone: cortical area1.42.22.5-1.5-1.6-1.6-1.51.61.4-1.6-1.4-1.0
Bone: cortical porosity0.10.10.30.30.40.40.6-0.4-0.20.30.30.4
Bone: cortical porosity0.00.00.1-0.1-0.1-0.10.20.10.1-0.0-0.00.2
Bone: cortical thickness0.50.91.1-0.9-1.0-1.0-1.01.00.8-1.0-0.9-0.8
Bone: cortical thickness1.31.51.9-1.2-1.3-1.3-1.41.31.1-1.3-1.1-1.3
Bone: cortical tissue density0.10.10.30.20.20.20.5-0.4-0.30.50.60.3
Condit. Reinf. active minus inactive responses0.40.40.8-0.8-0.9-0.9-0.40.70.6-0.5-0.5-0.0
Condit. Reinf. active-inactive response ratio0.30.30.6-0.8-0.7-0.7-0.40.60.5-0.3-0.30.0
Condit. Reinf. active responses0.20.30.6-0.8-0.7-0.7-0.30.60.6-0.4-0.30.1
Condit. Reinf. inactive responses0.10.10.10.20.40.40.1-0.3-0.10.30.20.2
Incentive salience index mean0.30.40.9-0.9-0.8-0.8-0.20.70.7-0.4-0.40.3
Condit. Reinf. lever presses0.10.20.5-0.7-0.3-0.30.10.30.6-0.0-0.10.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.1-0.2-0.2-0.30.30.1-0.3-0.2-0.5
Condit. Reinf. active-inactive response ratio0.30.31.0-0.1-0.4-0.4-0.80.50.1-0.6-0.5-1.0
Condit. Reinf. active responses0.10.10.10.30.30.30.3-0.3-0.30.30.30.1
Condit. Reinf. inactive responses0.50.71.00.70.80.81.0-0.9-0.71.00.90.7
Condit. Reinf. lever presses0.20.20.5-0.6-0.3-0.3-0.50.40.7-0.4-0.4-0.1
Condit. Reinf. lever reinforcers received0.10.10.10.40.40.40.3-0.3-0.30.30.30.1
Conditioned reinforcement - actives1.32.33.4-1.8-1.6-1.6-1.51.61.8-1.4-1.4-0.3
Conditioned reinforcement - inactives0.91.33.7-1.9-0.8-0.8-0.71.01.9-0.8-0.80.8
Conditioned locomotion2.02.54.0-1.0-1.7-1.7-1.81.60.9-1.7-1.5-2.0
Patch foraging indifference point 0 sec0.40.72.1-0.3-0.7-0.7-1.00.80.3-0.9-0.7-1.4
Patch foraging indifference point AUC3.24.76.5-2.5-2.2-2.2-2.12.32.5-2.2-2.0-1.0
Delay disc. indifference point, 0s delay1.11.33.40.71.01.01.2-1.0-0.71.20.91.9
Delay disc. indifference point, 16s delay1.01.12.80.11.11.11.1-1.00.01.11.01.7
Delay disc. indifference point, 2s delay2.73.06.00.71.91.91.9-1.8-0.41.91.52.5
Delay disc. indifference point, 24s delay0.00.10.2-0.1-0.1-0.1-0.30.10.1-0.2-0.1-0.5
Delay disc. indifference point, 4s delay0.00.00.10.10.00.00.00.0-0.2-0.0-0.20.3
Delay disc. indifference point, 8s delay1.51.82.51.51.21.21.4-1.3-1.61.41.11.2
Indifference point function ln k1.22.14.42.11.41.41.1-1.4-2.11.21.3-0.3
Indifference point function log k1.22.14.42.11.41.41.1-1.4-2.11.21.3-0.3
Patch foraging total patch changes 0 sec0.51.03.0-0.3-0.8-0.8-1.30.90.3-1.1-0.9-1.7
Patch foraging total patch changes 12 sec1.82.34.2-2.1-1.5-1.5-1.31.52.1-1.4-1.3-0.4
Patch foraging total patch changes 18 sec1.82.83.9-1.2-1.8-1.8-2.01.71.1-1.7-1.6-1.9
Patch foraging total patch changes 24 sec0.50.81.5-1.2-0.9-0.9-0.90.81.2-0.7-0.7-0.3
Patch foraging total patch changes 6 sec2.23.44.6-1.7-1.9-1.9-2.21.91.6-1.9-1.7-1.7
Patch foraging time to switch 0 sec2.14.46.21.72.02.02.5-2.1-1.72.31.92.4
Patch foraging water rate 0 sec2.45.07.0-1.9-2.2-2.2-2.62.41.8-2.4-2.2-2.5
Patch foraging water rate 12 sec0.10.20.4-0.4-0.4-0.4-0.60.40.5-0.4-0.4-0.6
Patch foraging water rate 18 sec0.10.20.4-0.5-0.1-0.1-0.70.30.6-0.4-0.4-0.3
Patch foraging water rate 24 sec0.50.82.4-0.1-0.8-0.8-1.10.70.0-0.9-0.7-1.6
Patch foraging water rate 6 sec0.50.81.3-1.0-0.7-0.7-1.10.91.0-0.9-0.8-0.8
Seeking ratio, delayed vs. immediate footshock1.72.12.51.51.51.51.6-1.6-1.51.61.50.8
Distance traveled before self-admin0.10.10.2-0.20.00.0-0.40.20.2-0.3-0.3-0.3
Distance traveled after self-admin0.20.20.50.30.70.70.4-0.5-0.00.40.40.2
Extensor digitorum longus weight1.76.68.0-2.6-2.8-2.8-2.72.72.3-2.7-2.5-1.7
Bone: elastic displacement0.81.01.41.00.70.71.2-1.0-1.21.21.10.8
Bone: elastic work0.10.10.2-0.4-0.4-0.4-0.10.20.2-0.1-0.10.3
Bone: endosteal estimation0.10.21.2-0.40.20.20.4-0.20.50.30.21.1
Bone: endosteal perimeter0.00.10.4-0.40.00.00.20.00.50.1-0.00.7
Epididymis fat weight0.20.61.60.20.60.60.9-0.7-0.10.90.71.3
Delta time in closed arm before/after self-admin0.20.20.40.60.40.40.3-0.5-0.50.40.3-0.6
Delta time in open arm before/after self-admin0.30.31.1-0.9-0.0-0.00.00.01.00.10.11.1
Diff in mean of infusions in LGA sessions1.62.04.62.01.11.11.3-1.3-2.21.31.20.3
Delay discount exponential model param1.01.12.0-0.7-1.2-1.2-1.11.10.7-1.1-0.9-1.4
Extinction: sum of active levers before priming0.10.10.40.5-0.1-0.10.3-0.2-0.70.20.20.4
Active lever presses in extinction session 60.20.20.50.4-0.4-0.4-0.20.4-0.7-0.2-0.30.5
Bone: final force0.40.71.2-1.1-0.9-0.9-0.80.81.0-0.8-0.8-0.2
Bone: final moment0.61.01.6-1.3-1.1-1.1-0.91.01.2-1.0-0.9-0.2
Food consumed during 24 hour testing period4.46.17.62.32.62.62.6-2.7-2.12.82.42.0
Glucose0.40.61.31.20.60.60.7-0.7-1.10.60.5-0.2
Heart weight1.72.73.6-1.2-1.7-1.7-1.81.81.1-1.9-1.6-1.8
Delay discount hyperbolic model param0.91.01.9-0.7-1.1-1.1-1.11.00.7-1.0-0.8-1.4
Intermittent access intake day 1-15 change0.10.20.2-0.3-0.5-0.5-0.50.40.2-0.4-0.5-0.0
Intermittent access intake escalation0.10.30.3-0.5-0.6-0.6-0.50.50.5-0.5-0.60.1
Intermittent access intake escalation 20.20.20.70.8-0.0-0.0-0.1-0.0-0.8-0.1-0.2-0.5
Intermitt. access day 1 inactive lever presses0.10.20.8-0.8-0.1-0.1-0.00.20.9-0.1-0.20.7
Intermitt. access day 15 inactive lever presses0.00.10.3-0.5-0.0-0.0-0.00.10.6-0.0-0.10.2
Intermitt. access escalation Index0.10.20.40.40.40.40.6-0.5-0.30.60.60.1
Intermittent access day 1 total infusions1.62.64.5-2.1-1.6-1.6-1.61.72.0-1.5-1.5-0.2
Intermittent access day 15 total infusions0.91.31.8-1.3-1.3-1.3-1.11.21.2-1.1-1.0-0.3
Intermittent access terminal intake (last 3 days)1.11.52.2-1.1-1.5-1.5-1.31.30.9-1.2-1.2-0.8
Intermittent access total infusions2.52.94.1-1.7-2.0-2.0-1.81.81.5-1.7-1.6-1.1
Intermittent access day 1 locomotion0.50.61.5-1.2-0.6-0.6-0.60.71.2-0.6-0.60.1
Intermittent access day 15 total locomotion0.10.30.6-0.7-0.4-0.4-0.50.50.8-0.5-0.5-0.1
Intermittent access total locomotion1.61.92.7-1.6-1.4-1.4-1.51.51.6-1.4-1.3-0.8
Intermittent access standard deviation0.10.20.30.60.40.40.4-0.5-0.50.40.40.2
Left kidney weight5.123.728.5-5.3-5.0-5.0-5.25.25.1-5.0-4.5-3.0
Right kidney weight4.620.724.2-4.6-4.9-4.9-4.94.94.2-4.8-4.3-3.2
Cocaine induced anxiety0.20.31.0-0.20.40.40.5-0.30.20.50.41.0
Post-drug Anxiety0.00.00.10.10.10.10.3-0.1-0.20.10.20.1
Baseline Anxiety0.80.93.21.5-0.0-0.0-0.0-0.3-1.7-0.10.2-1.8
Tail length0.51.83.8-2.0-1.3-1.3-1.21.41.8-1.1-1.20.3
Length with tail0.41.73.3-1.8-1.3-1.3-1.31.41.7-1.1-1.10.1
Length without tail0.31.11.5-1.0-1.2-1.2-1.21.10.9-1.0-0.9-0.6
Times rat made contact with spout0.10.10.20.40.30.3-0.0-0.2-0.40.20.2-0.4
Lifetime Intake2.63.24.3-2.0-2.1-2.1-1.71.81.8-1.7-1.5-0.9
Liver weight, left2.03.24.0-1.9-1.9-1.9-1.92.01.7-1.9-1.7-1.2
Liver weight, right1.52.64.7-2.2-1.8-1.8-1.51.71.9-1.3-1.2-0.3
Locomotor activity1.82.83.9-1.1-1.7-1.7-1.81.81.0-2.0-1.7-1.9
Locomotor testing distance1.01.82.4-1.3-1.3-1.3-1.51.51.3-1.5-1.5-0.8
Locomotor testing rearing3.87.79.2-2.8-2.9-2.9-2.93.02.6-3.0-2.7-1.9
Locomotion in novel chamber0.50.61.81.30.50.50.4-0.6-1.30.30.5-0.8
Locomotion in novel chamber post-restriction0.91.41.81.31.31.31.1-1.2-1.11.31.01.1
Fecal boli incidents, locomotor time 10.00.00.10.1-0.1-0.1-0.20.3-0.2-0.2-0.30.3
Change in fecal boli incidents, locomotor task0.60.61.40.30.70.70.9-0.8-0.20.90.71.2
Time >=10cm from walls, locomotor time 10.00.00.10.20.10.1-0.1-0.0-0.20.10.10.3
Bouts of movement, locomotor time 11.92.22.81.21.61.61.6-1.7-1.01.71.51.1
Total resting periods, locomotor time 12.52.73.61.31.81.81.8-1.9-1.11.91.71.4
Rest time, locomotor task time 10.10.20.30.10.50.50.5-0.50.10.50.40.5
Distance moved, locomotor task time 10.30.50.7-0.4-0.8-0.8-0.70.80.3-0.8-0.7-0.7
Vertical activity count, locomotor time 10.00.10.6-0.5-0.1-0.10.10.10.40.00.00.8
Time >=10cm from walls, locomotor time 20.10.20.5-0.50.30.30.3-0.20.70.20.10.6
Bouts of movement, locomotor time 24.57.29.93.12.82.82.7-2.8-3.12.72.41.3
Total resting periods, locomotor time 23.86.610.03.22.62.62.5-2.7-3.12.52.31.0
Rest time, locomotor task time 20.10.10.30.60.20.20.1-0.3-0.50.30.4-0.5
Distance moved, locomotor task time 21.01.22.5-1.5-1.0-1.0-0.91.01.6-1.0-1.0-0.5
Vertical activity count, locomotor time 20.20.31.9-0.50.10.10.3-0.10.50.20.11.4
Light reinforcement 10.00.10.2-0.4-0.2-0.2-0.40.30.4-0.3-0.20.0
Light reinforcement 20.50.72.3-1.4-0.3-0.3-0.30.51.5-0.3-0.41.2
Bone: marrow area0.10.21.0-0.40.10.10.3-0.10.50.20.11.0
Bone: maximum diameter2.13.84.7-2.1-2.2-2.2-1.92.12.0-2.0-1.8-1.3
Bone: maximum force0.20.30.6-0.8-0.6-0.6-0.60.60.7-0.6-0.60.1
Bone: maximum moment0.30.50.8-0.9-0.7-0.7-0.70.70.9-0.7-0.70.2
Mean time between licks in bursts0.00.00.2-0.10.10.10.1-0.20.10.30.30.4
Mean num. licks in bursts2.64.05.21.92.32.31.9-2.2-1.72.22.01.5
Cd content in liver0.30.41.41.10.30.30.2-0.4-1.20.20.3-0.6
Co content in liver1.11.21.51.21.01.01.2-1.2-1.21.21.10.6
Cu content in liver0.40.40.6-0.6-0.8-0.8-0.70.70.5-0.6-0.6-0.5
Fe content in liver4.55.48.4-1.6-2.5-2.5-2.52.41.5-2.5-2.2-2.9
K content in liver0.50.51.4-1.2-0.4-0.4-0.40.51.2-0.4-0.50.6
Mg content in liver0.90.92.2-1.4-0.8-0.8-0.70.91.5-0.7-0.80.1
Mn content in liver1.11.22.3-1.5-1.1-1.1-1.01.11.5-1.0-0.9-0.2
Na content in liver0.20.21.00.0-0.3-0.3-0.50.4-0.1-0.7-0.4-1.0
Rb content in liver0.10.10.1-0.3-0.2-0.2-0.30.20.3-0.2-0.3-0.1
Se content in liver3.64.35.2-2.0-2.3-2.3-2.12.31.9-2.2-2.0-1.5
Sr content in liver0.10.00.1-0.2-0.2-0.2-0.20.20.2-0.3-0.2-0.1
Zn content in liver0.80.81.0-1.0-1.0-1.0-1.01.00.9-1.0-1.0-0.1
Bone: minimum diameter0.20.30.6-0.8-0.5-0.5-0.60.60.8-0.6-0.60.0
Time in familiar zone, hab. session 10.10.10.2-0.2-0.3-0.3-0.30.40.3-0.5-0.4-0.5
Time in novel zone, hab. session 10.60.60.8-0.7-0.9-0.9-0.80.80.5-0.8-0.7-0.6
Total zone transitions, hab. session 10.10.10.4-0.2-0.3-0.3-0.50.40.2-0.4-0.4-0.6
Total locomotion distance, hab. session 10.30.40.60.50.70.70.7-0.7-0.40.70.60.6
Locomotion velocity, hab. session 11.01.41.80.91.31.31.2-1.3-0.71.31.21.2
Time in familiar zone, hab. session 20.30.30.4-0.3-0.6-0.6-0.60.60.1-0.5-0.5-0.5
Time in novel zone, hab. session 20.20.20.40.60.50.50.2-0.4-0.50.20.2-0.3
Total zone transitions, hab. session 20.40.51.0-0.5-0.8-0.8-0.70.80.5-0.8-0.7-1.0
Total locomotion distance, hab. session 20.40.60.80.60.80.80.9-0.8-0.50.80.80.5
Locomotion velocity, hab. session 20.30.40.50.30.70.70.7-0.6-0.10.70.60.6
Novel to familiar place preference ratio0.40.40.8-0.7-0.5-0.5-0.90.60.8-0.7-0.7-0.4
Novelty place preference0.40.40.7-0.6-0.4-0.4-0.80.60.8-0.7-0.7-0.4
Time in novel zone, NPP test0.40.50.8-0.6-0.5-0.5-0.90.70.7-0.8-0.8-0.6
Total zone transitions, NPP test0.10.10.2-0.4-0.3-0.3-0.40.30.4-0.4-0.4-0.4
Total locomotion distance, NPP test0.10.10.5-0.0-0.3-0.3-0.40.30.1-0.4-0.3-0.7
Locomotion velocity, NPP test0.10.10.2-0.1-0.2-0.2-0.30.20.2-0.3-0.3-0.5
Intraocular pressure0.30.51.61.1-0.0-0.00.1-0.2-1.20.00.1-1.1
Delta distance traveled before/after self-admin1.61.74.80.21.31.31.5-1.20.11.41.22.2
Delta ambulatory time before/after self-admin0.40.51.3-0.20.70.70.7-0.60.40.70.61.1
Parametrial fat weight0.10.20.5-0.7-0.4-0.4-0.30.40.7-0.5-0.20.0
Pavlov. Cond. lever latency0.40.50.70.70.80.80.6-0.8-0.50.70.60.6
Pavlov. Cond. magazine entry latency0.10.10.2-0.5-0.4-0.4-0.20.40.3-0.2-0.1-0.0
Pavlov. Cond. change in total contacts0.60.60.90.80.70.70.9-0.8-0.80.90.80.7
Pavlov. Cond. index score0.20.20.4-0.5-0.6-0.6-0.40.60.3-0.5-0.4-0.4
Pavlov. Cond. latency score0.00.00.1-0.3-0.3-0.3-0.10.30.1-0.2-0.1-0.2
Pavlov. Cond. lever contacts0.30.30.5-0.6-0.7-0.7-0.50.70.5-0.5-0.4-0.4
Pavlov. Cond. magazine entry number0.00.00.10.20.30.3-0.0-0.2-0.0-0.0-0.10.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.0-0.4-0.4-0.30.20.1-0.3-0.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.5-0.6-0.6-0.40.60.3-0.5-0.4-0.5
Pavlov. Cond. response bias0.70.91.2-1.1-1.1-1.1-0.91.10.8-0.9-0.8-0.6
Pavlov. Cond. lever latency0.00.00.00.20.20.20.2-0.1-0.20.20.2-0.1
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.1-0.1-0.10.10.2-0.0-0.00.1
Pavlov. Cond. change in total contacts0.20.30.50.70.70.70.3-0.6-0.60.50.50.1
Pavlov. Cond. index score0.00.00.1-0.00.20.20.0-0.20.10.20.10.4
Pavlov. Cond. latency score0.10.10.20.10.30.30.1-0.30.00.30.20.5
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3-0.3-0.30.30.5-0.3-0.30.1
Pavlov. Cond. magazine entry number0.30.30.6-0.4-0.6-0.6-0.60.60.3-0.7-0.5-0.8
Pavlov. Cond. intertrial magazine entries0.00.10.30.3-0.0-0.0-0.20.0-0.4-0.1-0.1-0.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.2-0.0-0.0-0.20.00.30.0-0.00.2
Pavlov. Cond. response bias0.00.00.1-0.10.00.00.0-0.00.10.10.10.3
Time in closed arm before self-admin0.60.81.4-0.1-0.9-0.9-1.21.0-0.1-1.0-1.0-1.0
Time in closed arm after self-admin1.21.22.71.61.11.10.9-1.1-1.70.90.9-0.1
Time in open arm before self-admin0.70.81.50.50.90.91.2-0.9-0.50.90.91.0
Time in open arm after self-admin0.40.41.6-0.80.10.10.4-0.21.00.30.31.3
Bone: periosteal estimation0.30.61.4-1.1-0.8-0.8-0.60.81.2-0.7-0.70.2
Bone: periosteal perimeter0.40.61.6-1.2-0.7-0.7-0.50.81.2-0.6-0.70.2
Bone: post-yield work0.71.02.80.31.11.10.9-1.0-0.21.10.81.7
Progressive ratio test 1 active lever presses2.93.65.5-2.3-2.0-2.0-1.82.02.2-1.8-1.7-0.5
Progressive ratio test 1 breakpoint2.83.46.0-2.4-1.9-1.9-1.71.92.3-1.7-1.6-0.2
Progressive ratio test 1 inactive lever presses1.31.93.2-1.8-1.1-1.1-1.41.51.8-1.4-1.4-0.1
Progressive ratio test 2 active lever presses2.52.94.0-2.0-2.0-2.0-1.61.81.8-1.7-1.5-0.6
Progressive ratio test 2 breakpoint2.83.24.4-2.0-2.1-2.1-1.71.91.9-1.7-1.6-0.7
Progressive ratio test 2 inactive lever presses0.61.02.8-1.6-0.7-0.7-0.40.71.7-0.5-0.61.2
Incentive Sensitization - Responses1.21.72.5-1.4-1.6-1.6-1.21.41.2-1.3-1.1-0.6
Incentive Sensitization - Breakpoint1.11.52.2-1.3-1.5-1.5-1.11.31.1-1.2-1.1-0.6
Sum of active levers in priming session hrs 5-60.90.93.71.60.20.20.6-0.5-1.90.50.5-0.3
Progressive ratio0.81.32.01.01.11.11.4-1.2-0.91.41.20.8
Food seeking constrained by brief footshock5.66.89.23.02.62.62.5-2.6-3.02.52.32.2
Seeking ratio, punishment vs. effort0.71.11.61.21.11.10.8-0.9-1.20.80.71.3
Retroperitoneal fat weight0.00.10.2-0.5-0.4-0.4-0.20.40.4-0.4-0.3-0.1
Reaction time number correct3.36.310.9-1.5-2.6-2.6-3.02.61.2-2.8-2.3-3.3
Reaction time mean minus median0.41.02.91.70.50.50.4-0.7-1.70.30.4-1.3
Reaction time mean minus median AUC0.30.73.41.1-0.3-0.3-0.30.1-1.1-0.4-0.2-1.8
Reaction time num false alarms4.66.49.6-3.1-2.7-2.7-2.52.62.9-2.4-2.2-1.3
Reaction time num false alarms AUC3.75.89.2-3.0-2.5-2.5-2.32.52.9-2.3-2.0-1.0
Reaction time trials correct on left3.36.310.9-1.5-2.6-2.6-3.02.61.2-2.8-2.3-3.3
Reaction time trials on left3.36.210.4-1.5-2.6-2.6-3.02.61.3-2.8-2.3-3.2
Reaction time mean1.32.03.11.81.31.31.5-1.5-1.71.41.30.7
Reaction time mean AUC1.01.62.71.71.11.11.3-1.3-1.61.21.10.5
Median of all reaction times1.52.12.71.41.31.31.7-1.5-1.41.61.41.4
Reaction time omissions0.00.00.3-0.1-0.2-0.20.00.1-0.00.1-0.10.5
Reaction time false alarm rate0.60.82.4-1.5-0.7-0.7-0.30.61.5-0.3-0.40.8
Reaction time premature initiation rate0.50.71.90.11.01.00.9-0.70.10.90.81.4
Reaction time premature initiations0.10.30.5-0.5-0.3-0.3-0.70.50.5-0.6-0.5-0.5
Std. dev. reaction times0.40.82.21.50.60.60.6-0.8-1.50.50.6-0.7
Reaction time trials completed3.36.210.4-1.5-2.6-2.6-3.02.61.3-2.8-2.3-3.2
Reaction time trials AUC4.07.611.8-1.8-2.8-2.8-3.32.91.5-3.1-2.6-3.4
Run reversals in cocaine runway, females0.30.30.5-0.10.70.70.5-0.50.30.50.50.6
Run reversals in cocaine runway, males0.40.40.5-0.5-0.7-0.7-0.70.70.4-0.7-0.6-0.7
Latency to leave start box in cocaine runway0.10.10.70.40.10.1-0.4-0.0-0.3-0.1-0.2-0.8
Latency to leave start box in cocaine runway, F0.50.62.30.1-0.5-0.5-1.00.6-0.1-0.8-0.8-1.5
Latency to leave start box in cocaine runway, M0.10.10.20.30.50.50.3-0.4-0.20.40.40.3
Std. dev. time between licks in bursts0.10.10.4-0.6-0.3-0.3-0.20.20.60.0-0.00.5
Total sessions with >9 infusions3.64.45.6-2.0-2.4-2.4-2.22.21.8-2.1-1.9-1.8
Short access day 1 total inactive lever presses2.02.68.4-2.8-1.1-1.1-0.81.12.9-0.8-0.81.3
Short access day 10 total inactive lever presses0.51.11.60.81.11.11.2-1.1-0.71.11.01.1
Short access day 1 total infusions2.22.93.8-1.9-1.9-1.9-1.61.71.8-1.6-1.3-1.2
Short access day 10 total infusions3.74.75.9-2.4-2.4-2.4-2.22.32.2-2.1-1.9-1.3
Short access total infusions2.53.24.4-2.1-2.0-2.0-1.71.82.0-1.7-1.5-0.9
Short access day 1 locomotion3.44.26.3-2.5-2.2-2.2-2.12.22.3-2.0-1.8-1.0
Short access day 10 total locomotion0.00.00.30.10.00.0-0.1-0.0-0.1-0.00.0-0.5
Short access total locomotion0.91.01.8-1.3-1.0-1.0-1.01.01.3-0.9-0.8-0.5
One hour access (0.3 mA shock)0.10.10.2-0.4-0.4-0.4-0.20.20.4-0.2-0.20.2
Compulsive drug intake0.20.21.0-0.2-0.3-0.3-0.60.30.3-0.5-0.4-1.0
One hour access (shock baseline)1.01.52.0-1.4-1.4-1.4-1.21.31.2-1.1-1.1-0.4
Social response proportion0.70.81.6-0.5-0.8-0.8-1.10.90.4-1.0-0.8-1.2
Social responses0.70.91.1-1.0-0.9-0.9-1.01.01.0-1.0-0.9-0.8
Social time3.14.36.21.42.42.42.1-2.1-1.12.11.92.5
Soleus weight0.10.30.5-0.7-0.6-0.6-0.60.60.6-0.6-0.5-0.3
Bone: stiffness0.71.21.6-1.2-1.0-1.0-1.21.11.2-1.3-1.2-0.5
Tibialis anterior weight3.010.111.5-3.4-3.3-3.3-3.43.43.1-3.3-3.1-1.9
Time to tail flick, vehicle, before self-admin2.52.63.2-1.3-1.7-1.7-1.71.71.2-1.8-1.4-1.8
Time to tail flick, vehicle, after self-admin0.20.21.40.60.10.1-0.1-0.1-0.6-0.20.0-1.2
Time to tail flick, test, before self-admin0.30.30.60.60.20.20.7-0.6-0.80.70.60.5
Time to tail flick, test, after self-admin0.20.20.9-0.30.40.40.5-0.30.30.40.51.0
Delta time to tail flick, vehicle, before/after SA0.20.20.40.60.40.40.3-0.5-0.60.30.3-0.3
Delta time to tail flick, test, before/after SA0.80.81.9-1.2-0.6-0.6-1.00.91.4-1.0-0.8-0.4
Tibia length0.30.92.1-1.4-0.9-0.9-0.70.91.4-0.6-0.70.2
Ambulatory time before self-admin0.00.00.10.30.20.2-0.0-0.1-0.30.00.0-0.1
Ambulatory time after self-admin0.50.50.90.71.01.00.7-0.8-0.50.70.70.2
Bone: tissue strength0.80.80.90.91.01.00.9-0.9-0.80.90.80.9
Total heroin consumption0.00.10.30.2-0.0-0.00.10.0-0.30.10.00.6
Bone: trabecular number0.00.10.20.00.10.10.2-0.2-0.10.30.40.4
Bone: trabecular spacing0.00.10.20.3-0.1-0.1-0.20.2-0.3-0.3-0.3-0.5
Bone: trabecular thickness1.41.72.2-1.3-1.5-1.5-1.41.31.2-1.3-1.1-1.1
Bone: trabecular tissue density0.30.40.7-0.5-0.6-0.6-0.60.70.5-0.6-0.6-0.8
Water consumed over 24 hours0.20.20.30.60.40.40.3-0.5-0.60.50.5-0.1
Number of responses in last shaping day3.03.35.1-1.2-2.3-2.3-1.91.80.8-1.8-1.5-2.3