Hub : Genes

Focad

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative TSS XM_039111095.2 0.07 0.05 2.4e-05 0.03 0.04 0.05 0.03 1.1e-03 7.6e-04 3.5e-05 1.5e-03
2 pVTA isoform ratio XM_039111095.2 0.07 0.05 1.2e-05 0.04 0.04 0.05 0.03 3.8e-04 3.5e-04 8.5e-05 1.1e-03
3 OFC mRNA stability Focad 0.39 0.21 8.7e-05 0.06 0.1 0.09 0.08 1.6e-02 2.9e-03 3.1e-03 6.8e-03
4 Adipose gene expression Focad 0.07 0.05 7.2e-08 0.05 0.06 0.05 0.05 1.1e-06 9.3e-07 1.3e-06 1.2e-06
5 Brain isoform ratio XM_039111095.2 0.02 0.02 7.4e-03 0.01 0.02 0.01 0.01 6.8e-02 5.9e-03 7.2e-02 6.6e-02
6 Brain alternative TSS XM_039111095.2 0.03 0.02 2.4e-03 0.01 0.03 0.01 0.01 3.2e-02 1.6e-03 3.1e-02 2.0e-02
7 Adipose intron excision ratio chr5_107651848_107656190 0.04 0.03 3.1e-04 0.01 0.01 0.02 0.02 5.6e-02 6.9e-03 2.1e-03 4.6e-03
8 OFC gene expression Focad 0.23 0.14 1.0e-03 0.06 0.06 0.06 0.06 1.6e-02 1.8e-02 1.3e-02 2.0e-02
9 BLA gene expression Focad 0.33 0.14 4.8e-14 0.25 0.23 0.25 0.25 1.6e-13 1.0e-12 1.8e-13 1.4e-13
10 LHb gene expression Focad 0.57 0.19 8.2e-08 0.17 0.12 0.16 0.18 8.2e-05 7.2e-04 1.0e-04 4.6e-05
11 Adipose mRNA stability Focad 0.05 0.04 5.1e-05 0.04 0.02 0.03 0.03 6.4e-05 1.1e-03 6.9e-04 2.4e-04
12 pVTA gene expression Focad 0.41 0.1 0.0e+00 0.51 0.5 0.51 0.51 5.7e-47 2.2e-46 2.8e-47 5.3e-47
13 Adipose intron excision ratio chr5_107648816_107651774 0.03 0.03 3.4e-03 0.01 0 0 0.01 1.5e-02 8.0e-02 8.7e-02 7.1e-02
14 IC intron excision ratio chr5_107902906_107915371 0.06 0.05 8.6e-03 0.04 0.03 0.02 0.02 1.0e-02 3.1e-02 4.0e-02 3.3e-02
15 IL gene expression Focad 0.51 0.17 2.4e-09 0.25 0.22 0.21 0.21 8.3e-07 6.6e-06 1.0e-05 9.4e-06
16 Brain gene expression Focad 0.46 0.13 0.0e+00 0.53 0.55 0.54 0.54 7.4e-58 2.4e-61 4.9e-60 7.9e-60
17 RMTg gene expression Focad 0.21 0.14 1.2e-03 0.06 0.05 0.03 0.05 1.5e-02 1.9e-02 7.2e-02 2.0e-02
18 PL gene expression Focad 0.33 0.12 0.0e+00 0.37 0.37 0.37 0.37 5.9e-43 1.2e-42 1.0e-42 1.4e-42
19 NAcc gene expression Focad 0.28 0.1 0.0e+00 0.36 0.36 0.36 0.36 3.5e-58 4.1e-58 1.0e-57 5.1e-58
20 IC gene expression Focad 0.38 0.17 1.1e-15 0.32 0.31 0.31 0.31 3.3e-14 1.9e-13 1.1e-13 2.0e-13
21 PL intron excision ratio chr5_107902906_107915371 0.06 0.05 9.2e-03 0.02 0.01 0.01 0.02 1.0e-03 1.2e-02 1.9e-02 3.4e-03
22 Brain intron excision ratio chr5_107902906_107915371 0.04 0.03 4.8e-03 0.01 0.02 0.01 0.01 4.7e-02 8.6e-03 1.9e-02 2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.91.611.9-1.8-2.12.21.3-1.0-0.9-0.7-0.00.1-0.1-0.0-0.2-0.1-0.00.0-0.10.10.00.00.0-3.5-2.5
Area under the delay curve0.70.94.6-1.5-1.71.61.1-0.9-0.8-0.6-0.1-0.2-0.3-0.3-0.30.20.3-0.3-0.3-0.2-0.1-0.2-0.1-2.2-1.6
BMI with tail3.311.322.84.74.8-4.6-4.24.03.93.53.02.93.23.23.1-2.9-3.03.03.02.93.03.02.82.30.7
BMI without tail1.23.58.82.72.8-3.0-2.32.22.12.11.51.41.51.51.6-1.4-1.41.41.51.41.51.41.32.41.1
Body weight0.83.47.42.72.7-2.5-2.42.22.21.91.61.61.71.71.7-1.7-1.51.51.61.71.61.51.71.00.4
Weight adjusted by age0.10.10.2-0.4-0.30.20.3-0.3-0.3-0.2-0.5-0.3-0.3-0.3-0.20.20.5-0.5-0.3-0.3-0.3-0.3-0.30.20.2
Bone surface0.00.10.6-0.0-0.10.2-0.10.10.10.10.20.30.30.30.2-0.3-0.20.20.20.30.30.30.2-0.7-0.5
Bone volume0.10.22.0-0.4-0.60.60.2-0.2-0.1-0.10.10.20.20.20.1-0.3-0.20.20.10.30.20.20.2-1.4-1.0
Breakpoint value in progressive ratio session0.30.41.60.40.4-0.20.1-0.2-0.3-0.6-0.8-0.7-0.5-0.5-0.60.60.7-0.7-0.6-0.5-0.4-0.5-0.61.11.3
Number of licking bursts0.20.32.30.70.8-0.9-0.50.40.30.50.10.10.10.20.10.00.0-0.00.1-0.0-0.0-0.0-0.11.51.0
Context. condit. distance diff. score0.10.10.6-0.5-0.60.60.4-0.4-0.4-0.4-0.3-0.2-0.3-0.3-0.30.20.2-0.2-0.3-0.2-0.2-0.2-0.2-0.8-0.3
Locomotion velocity, session 10.00.00.4-0.1-0.20.20.00.00.0-0.00.10.10.20.20.1-0.1-0.10.10.10.10.10.10.1-0.7-0.4
Locomotion distance, session 10.50.62.30.30.0-0.0-0.50.50.60.50.90.80.91.00.8-0.8-0.80.80.80.80.80.80.8-1.5-1.3
Locomotion velocity, session 20.10.10.3-0.0-0.0-0.0-0.10.20.20.30.40.40.20.20.3-0.3-0.30.30.30.30.30.30.3-0.5-0.5
Locomotion distance, session 21.52.23.50.80.6-0.7-1.11.21.31.31.61.71.61.61.5-1.6-1.61.61.61.61.61.61.6-1.8-1.9
Locomotion velocity, session 30.70.81.1-0.7-0.80.80.9-0.9-0.9-1.0-1.0-1.0-0.9-0.9-0.90.90.9-0.9-0.9-0.9-0.9-0.9-0.90.10.6
Locomotion distance, session 30.20.20.60.80.7-0.6-0.60.50.50.40.30.30.40.30.3-0.3-0.30.30.30.30.30.30.30.30.2
Stereotopy head waving bouts, day 31.31.62.0-1.2-1.11.11.3-1.3-1.3-1.4-1.4-1.4-1.4-1.3-1.31.31.3-1.3-1.3-1.3-1.3-1.3-1.30.40.9
Stereotopy head waving duration, day 31.62.03.3-1.8-1.81.81.7-1.6-1.6-1.6-1.4-1.4-1.4-1.3-1.41.31.3-1.3-1.3-1.3-1.3-1.3-1.3-0.80.0
Locomotion velocity, session 70.30.31.8-0.9-1.00.80.5-0.4-0.3-0.10.20.20.20.20.0-0.1-0.10.10.10.10.10.10.1-1.3-1.2
Locomotion distance, session 70.70.93.0-1.7-1.71.41.3-1.1-1.1-0.7-0.5-0.5-0.6-0.6-0.70.60.6-0.6-0.6-0.6-0.6-0.6-0.6-1.1-0.8
Stereotopy head waving bouts, day 70.30.31.70.70.8-0.5-0.30.10.1-0.2-0.5-0.4-0.5-0.4-0.30.30.3-0.3-0.3-0.3-0.3-0.3-0.31.31.3
Stereotopy head waving duration, day 70.10.20.90.50.6-0.4-0.20.10.1-0.2-0.4-0.3-0.4-0.3-0.20.30.3-0.3-0.3-0.3-0.3-0.3-0.30.91.0
Locomotion velocity, session 80.70.81.00.80.7-0.7-0.90.90.90.91.01.00.90.91.0-1.0-0.90.90.91.00.90.91.0-0.7-0.8
Locomotion distance, session 80.60.93.20.2-0.10.0-0.50.60.60.71.01.01.00.90.9-1.0-1.01.00.91.01.01.01.0-1.8-1.6
Degree of sensitization distance0.70.72.4-1.6-1.41.01.2-1.1-1.0-0.6-0.6-0.6-0.7-0.7-0.70.70.7-0.7-0.6-0.7-0.7-0.7-0.7-0.0-0.2
Degree of sensitization stereotypy0.40.42.60.91.1-0.9-0.50.40.30.1-0.4-0.3-0.3-0.3-0.10.20.2-0.2-0.2-0.2-0.2-0.2-0.21.61.5
Conditioned locomotion0.20.30.60.70.8-0.8-0.60.60.60.60.40.50.30.30.4-0.4-0.40.40.40.40.50.50.50.50.2
Cocaine response after cond. corrected1.11.42.91.71.7-1.6-1.51.41.41.11.01.01.11.21.1-1.0-1.01.01.01.01.01.01.00.70.3
Cocaine response after cond. not corrected3.44.05.62.42.3-2.1-2.32.22.22.02.02.02.12.12.0-1.9-2.02.02.01.92.02.02.0-0.0-0.7
Cocaine response before conditioning2.42.84.31.00.8-0.8-1.31.41.51.62.01.91.91.81.8-1.8-1.91.91.81.91.81.81.8-1.7-2.1
Saline control response4.35.710.93.23.3-3.2-2.92.82.72.82.32.32.02.02.3-2.1-2.12.12.22.12.12.12.11.50.3
Bone: connectivity density0.20.32.8-0.4-0.60.60.2-0.1-0.00.00.30.40.40.40.3-0.4-0.40.40.30.40.40.40.4-1.7-1.3
Bone: cortical apparent density0.00.00.1-0.3-0.20.10.2-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.20.20.1-0.1-0.1-0.2-0.1-0.1-0.20.30.1
Bone: cortical area6.39.711.72.92.8-2.9-3.13.23.23.43.43.43.33.43.3-3.3-3.33.33.33.33.33.33.2-0.7-2.0
Bone: cortical porosity2.22.43.41.11.0-1.2-1.31.41.41.71.91.81.71.71.6-1.6-1.71.71.71.61.71.71.6-0.7-1.4
Bone: cortical porosity4.34.76.31.91.8-2.1-2.12.22.22.52.52.42.32.32.3-2.2-2.32.32.32.22.32.32.2-0.3-1.4
Bone: cortical thickness8.013.216.72.92.7-2.8-3.43.53.63.84.14.14.04.03.9-3.9-3.93.93.93.93.93.93.9-2.0-3.3
Bone: cortical thickness6.17.19.12.32.1-2.1-2.62.62.72.73.02.92.92.92.8-2.9-2.92.92.82.92.82.82.8-1.5-2.3
Bone: cortical tissue density0.10.10.2-0.4-0.40.20.4-0.4-0.4-0.3-0.4-0.4-0.3-0.3-0.40.40.3-0.3-0.3-0.4-0.3-0.3-0.40.50.3
Condit. Reinf. active minus inactive responses0.10.20.7-0.8-0.80.70.5-0.4-0.4-0.2-0.0-0.10.00.1-0.10.00.1-0.1-0.1-0.0-0.1-0.1-0.0-0.9-0.8
Condit. Reinf. active-inactive response ratio0.10.10.2-0.5-0.40.40.4-0.4-0.3-0.4-0.3-0.3-0.1-0.1-0.30.30.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.1
Condit. Reinf. active responses0.20.21.2-0.8-0.90.80.6-0.5-0.4-0.3-0.1-0.1-0.1-0.1-0.20.10.1-0.1-0.2-0.1-0.1-0.1-0.1-1.1-0.8
Condit. Reinf. inactive responses0.10.10.6-0.5-0.60.60.4-0.3-0.3-0.2-0.1-0.1-0.2-0.2-0.20.10.1-0.1-0.1-0.1-0.1-0.1-0.1-0.8-0.5
Incentive salience index mean0.50.62.10.40.2-0.1-0.50.60.60.50.80.80.91.00.8-0.8-0.80.80.80.80.80.80.8-1.4-1.3
Condit. Reinf. lever presses1.52.23.11.61.3-0.8-1.51.51.51.01.41.41.61.81.4-1.5-1.51.51.41.51.51.51.5-1.7-1.4
Condit. Reinf. active minus inactive responses1.92.53.31.31.2-1.2-1.51.51.51.71.81.81.71.71.7-1.7-1.81.81.71.71.71.71.7-0.9-1.4
Condit. Reinf. active-inactive response ratio4.95.67.42.12.1-2.2-2.42.42.42.72.72.72.42.42.5-2.5-2.52.52.52.52.52.52.5-0.5-1.6
Condit. Reinf. active responses0.91.22.80.40.3-0.3-0.60.80.81.01.31.31.11.21.1-1.2-1.31.31.11.21.21.21.1-1.4-1.7
Condit. Reinf. inactive responses0.91.23.5-1.7-1.81.91.4-1.3-1.2-1.1-0.6-0.6-0.6-0.6-0.80.60.5-0.5-0.7-0.6-0.7-0.7-0.7-1.8-1.2
Condit. Reinf. lever presses4.36.07.22.72.6-2.5-2.72.72.72.72.62.62.52.52.5-2.5-2.62.62.52.52.52.52.4-0.1-1.1
Condit. Reinf. lever reinforcers received0.70.91.90.40.3-0.3-0.60.70.80.91.11.11.01.01.0-1.1-1.11.11.01.11.01.01.0-1.1-1.4
Conditioned reinforcement - actives1.72.93.71.81.7-1.4-1.71.81.81.61.71.81.81.81.7-1.8-1.91.91.71.81.91.91.7-0.8-1.1
Conditioned reinforcement - inactives0.91.43.20.40.3-0.3-0.70.90.90.91.21.31.31.31.2-1.3-1.21.21.21.31.41.21.2-1.8-1.8
Conditioned locomotion5.36.99.23.03.0-2.7-2.92.92.92.72.72.72.62.62.7-2.7-2.72.72.62.72.82.72.5-0.5-1.2
Patch foraging indifference point 0 sec2.13.910.83.03.2-3.3-2.52.32.22.31.31.51.21.11.6-1.4-1.31.31.51.41.31.21.33.01.6
Patch foraging indifference point AUC0.20.30.90.90.9-0.8-0.70.70.60.30.20.10.60.60.4-0.2-0.20.20.40.20.30.30.40.60.5
Delay disc. indifference point, 0s delay1.21.311.2-0.8-1.01.20.3-0.10.0-0.10.80.60.91.00.6-0.6-0.50.50.60.60.80.70.8-3.3-2.6
Delay disc. indifference point, 16s delay0.70.82.6-1.4-1.61.51.2-1.0-1.0-0.9-0.5-0.5-0.6-0.5-0.60.50.6-0.6-0.6-0.5-0.5-0.5-0.5-1.4-0.9
Delay disc. indifference point, 2s delay0.91.02.8-1.6-1.71.61.3-1.2-1.1-0.9-0.6-0.7-0.8-0.8-0.80.70.8-0.8-0.7-0.7-0.6-0.6-0.6-1.3-0.8
Delay disc. indifference point, 24s delay1.01.12.5-1.6-1.61.61.4-1.3-1.2-1.0-0.9-0.7-1.1-1.1-0.90.70.9-0.9-0.9-0.7-0.8-0.9-0.8-1.1-0.5
Delay disc. indifference point, 4s delay0.50.52.6-1.2-1.31.20.8-0.7-0.6-0.5-0.0-0.1-0.2-0.1-0.30.20.2-0.2-0.2-0.2-0.1-0.0-0.1-1.6-1.2
Delay disc. indifference point, 8s delay0.50.64.8-0.7-0.90.90.3-0.1-0.00.10.60.60.30.40.4-0.5-0.50.50.40.50.60.60.6-2.2-1.9
Indifference point function ln k1.11.93.10.80.7-0.6-1.01.11.21.51.51.81.21.21.4-1.7-1.51.51.41.61.51.41.5-1.5-1.8
Indifference point function log k1.11.93.10.80.7-0.6-1.01.11.21.51.51.81.21.21.4-1.7-1.51.51.41.61.51.41.5-1.5-1.8
Patch foraging total patch changes 0 sec2.34.311.03.03.3-3.3-2.62.42.32.41.51.71.41.21.7-1.6-1.51.51.61.51.51.41.42.71.4
Patch foraging total patch changes 12 sec0.71.07.61.31.6-1.6-0.90.70.60.4-0.2-0.3-0.1-0.10.10.30.2-0.2-0.0-0.3-0.1-0.1-0.12.82.1
Patch foraging total patch changes 18 sec1.42.14.11.92.0-2.0-1.81.71.71.51.31.21.41.41.4-1.2-1.31.31.41.31.31.21.30.90.2
Patch foraging total patch changes 24 sec4.47.613.83.63.7-3.7-3.33.23.13.12.62.62.62.52.7-2.5-2.52.52.62.52.42.42.41.50.1
Patch foraging total patch changes 6 sec5.38.117.14.04.1-4.1-3.63.43.33.22.42.42.62.52.7-2.3-2.32.32.52.32.42.32.32.30.8
Patch foraging time to switch 0 sec3.36.910.2-3.2-3.12.93.1-3.0-3.0-2.7-2.5-2.7-2.7-2.6-2.72.72.4-2.4-2.6-2.7-2.6-2.4-2.70.20.9
Patch foraging water rate 0 sec2.75.712.83.53.6-3.3-3.12.92.82.52.02.12.11.92.2-2.0-2.02.02.12.02.01.92.01.60.6
Patch foraging water rate 12 sec2.04.29.12.93.0-2.8-2.62.42.42.21.71.91.71.61.9-1.9-1.81.81.81.91.71.71.81.30.4
Patch foraging water rate 18 sec5.17.810.63.23.1-2.8-3.23.13.12.92.92.92.72.72.9-2.9-2.92.92.82.92.72.72.7-0.6-1.3
Patch foraging water rate 24 sec1.62.24.22.02.0-1.7-1.81.81.71.71.41.61.10.91.4-1.5-1.41.41.41.51.31.31.40.1-0.2
Patch foraging water rate 6 sec2.53.66.32.42.4-2.5-2.32.22.22.31.81.91.61.51.9-1.8-1.91.91.81.81.71.71.80.9-0.0
Seeking ratio, delayed vs. immediate footshock4.15.06.82.62.5-1.9-2.52.52.52.22.32.32.52.42.3-2.4-2.02.02.22.42.42.12.4-1.2-1.4
Distance traveled before self-admin1.31.73.2-0.8-0.81.11.1-1.2-1.2-1.8-1.7-1.6-1.2-1.2-1.41.51.4-1.4-1.4-1.5-1.3-1.2-1.50.51.2
Distance traveled after self-admin4.25.19.2-1.9-1.92.32.2-2.3-2.3-3.0-2.7-2.7-2.0-2.2-2.52.52.2-2.2-2.5-2.5-2.3-2.0-2.50.21.4
Extensor digitorum longus weight1.24.68.3-2.9-2.82.52.6-2.5-2.5-2.1-2.0-2.0-2.2-2.2-2.12.02.0-2.0-2.1-2.0-2.0-2.0-2.0-0.40.3
Bone: elastic displacement0.70.82.6-1.5-1.61.41.2-1.1-1.0-0.7-0.4-0.5-0.6-0.6-0.60.50.5-0.5-0.6-0.5-0.5-0.5-0.5-1.2-0.9
Bone: elastic work1.41.84.30.40.2-0.4-0.81.01.01.41.71.61.51.51.4-1.5-1.41.41.41.51.41.41.5-1.8-2.1
Bone: endosteal estimation0.30.64.60.60.8-0.9-0.30.20.10.1-0.4-0.4-0.5-0.5-0.30.40.5-0.5-0.4-0.4-0.4-0.5-0.52.21.8
Bone: endosteal perimeter0.20.52.5-0.10.0-0.20.3-0.4-0.4-0.3-0.7-0.7-0.8-0.8-0.60.70.7-0.7-0.6-0.7-0.7-0.7-0.71.61.4
Epididymis fat weight0.20.84.01.61.7-1.6-1.21.00.90.60.20.20.40.30.4-0.30.0-0.00.30.30.30.00.32.01.5
Delta time in closed arm before/after self-admin0.00.00.10.10.1-0.2-0.10.10.10.20.30.0-0.10.00.10.1-0.20.20.1-0.10.10.20.00.40.1
Delta time in open arm before/after self-admin1.11.11.8-1.1-1.11.01.1-1.1-1.1-1.1-1.2-1.0-0.9-1.3-1.10.91.1-1.1-1.1-0.9-1.1-1.1-1.10.30.6
Diff in mean of infusions in LGA sessions0.60.73.31.41.6-1.4-0.90.80.70.50.40.20.40.40.3-0.3-0.40.40.30.30.50.40.11.81.2
Delay discount exponential model param0.80.94.01.61.8-1.7-1.21.00.90.70.30.30.50.40.5-0.3-0.40.40.40.30.30.30.32.01.5
Extinction: sum of active levers before priming2.12.34.52.12.1-1.8-1.81.71.71.31.41.31.71.71.4-1.4-1.51.51.41.41.61.61.30.5-0.1
Active lever presses in extinction session 62.02.05.12.22.3-2.0-1.91.71.71.31.11.01.31.31.3-1.0-1.01.01.21.11.11.21.11.20.6
Bone: final force2.54.05.52.32.3-2.3-2.32.22.22.12.02.02.12.12.0-1.9-2.02.02.01.92.02.01.90.4-0.5
Bone: final moment2.03.34.92.22.2-2.2-2.12.12.02.01.81.81.91.91.8-1.7-1.81.81.81.71.71.71.70.6-0.3
Food consumed during 24 hour testing period2.33.25.91.00.7-0.7-1.31.51.61.21.91.92.12.11.9-2.1-2.02.01.92.11.81.81.8-2.1-2.4
Glucose0.10.20.40.40.4-0.6-0.50.50.50.70.50.50.40.40.4-0.4-0.40.40.40.40.40.40.40.4-0.0
Heart weight5.58.610.82.72.3-1.9-2.82.82.92.73.33.23.23.13.0-3.1-3.23.23.03.13.33.23.2-2.3-2.7
Delay discount hyperbolic model param0.91.03.11.61.7-1.7-1.31.11.00.90.40.50.60.60.6-0.5-0.60.60.60.50.40.40.41.81.2
Intermittent access intake day 1-15 change0.10.32.6-0.5-0.71.00.5-0.4-0.4-0.8-0.2-0.20.10.1-0.30.10.1-0.1-0.2-0.1-0.10.0-0.3-1.6-0.8
Intermittent access intake escalation0.20.42.3-0.6-0.81.10.6-0.5-0.5-0.9-0.4-0.4-0.0-0.0-0.40.30.2-0.2-0.3-0.3-0.2-0.1-0.4-1.5-0.7
Intermittent access intake escalation 20.10.10.80.40.30.1-0.30.30.3-0.30.20.10.50.50.2-0.2-0.30.30.20.20.30.40.1-0.9-0.4
Intermitt. access day 1 inactive lever presses0.00.10.30.50.5-0.5-0.50.40.40.40.30.20.20.20.3-0.1-0.50.50.30.10.20.40.30.40.2
Intermitt. access day 15 inactive lever presses0.40.91.21.11.1-1.1-1.01.01.01.10.81.10.80.81.0-1.1-0.70.70.91.11.00.81.00.1-0.3
Intermitt. access escalation Index1.01.42.7-1.7-1.61.51.5-1.4-1.4-1.1-1.1-1.0-1.3-1.3-1.11.11.0-1.0-1.1-1.1-1.1-1.0-1.0-0.5-0.0
Intermittent access day 1 total infusions0.00.00.1-0.4-0.3-0.00.1-0.1-0.10.20.10.10.10.10.1-0.1-0.00.00.10.10.00.0-0.00.1-0.3
Intermittent access day 15 total infusions0.10.21.1-0.5-0.60.70.4-0.4-0.4-0.6-0.3-0.30.10.1-0.30.20.1-0.1-0.2-0.2-0.30.0-0.4-1.1-0.5
Intermittent access terminal intake (last 3 days)0.30.31.6-0.7-0.81.00.7-0.6-0.6-0.8-0.4-0.4-0.0-0.0-0.40.30.2-0.2-0.4-0.3-0.4-0.1-0.5-1.3-0.6
Intermittent access total infusions0.60.72.00.1-0.00.0-0.40.50.50.40.80.81.11.10.7-0.8-0.90.90.80.80.71.00.6-1.4-1.4
Intermittent access day 1 locomotion0.10.10.20.30.4-0.4-0.30.30.30.30.20.20.20.20.2-0.2-0.30.30.20.20.20.30.10.40.2
Intermittent access day 15 total locomotion0.00.00.20.30.4-0.3-0.20.20.1-0.1-0.2-0.20.00.0-0.00.1-0.00.0-0.0-0.1-0.00.2-0.20.40.5
Intermittent access total locomotion0.10.10.20.40.5-0.4-0.40.40.40.40.20.30.30.30.3-0.4-0.30.30.30.40.30.40.2-0.1-0.1
Intermittent access standard deviation0.10.32.5-0.5-0.60.90.4-0.3-0.3-0.6-0.1-0.10.10.1-0.20.00.1-0.1-0.1-0.00.00.0-0.1-1.6-0.9
Left kidney weight4.420.724.34.94.6-4.4-4.94.94.94.94.94.94.74.74.7-4.7-4.64.64.74.74.64.64.8-0.9-2.5
Right kidney weight5.022.827.35.24.9-4.9-5.25.25.25.25.15.05.05.05.0-4.9-4.84.84.94.94.74.84.9-0.4-2.3
Cocaine induced anxiety0.81.12.9-1.7-1.71.51.4-1.3-1.2-0.7-0.7-0.6-1.3-1.3-0.90.71.0-1.0-0.8-0.7-0.7-1.0-0.7-1.0-0.5
Post-drug Anxiety1.31.43.0-1.3-1.21.11.2-1.2-1.2-0.7-1.1-0.9-1.7-1.7-1.11.01.4-1.4-1.1-1.0-1.1-1.5-0.90.10.5
Baseline Anxiety1.11.34.70.20.4-0.20.3-0.5-0.5-0.8-1.3-1.2-1.1-1.1-0.91.11.2-1.2-1.1-1.1-1.3-1.4-1.12.12.2
Tail length0.51.93.9-2.0-1.91.71.7-1.6-1.6-1.2-1.3-1.1-1.3-1.4-1.31.11.3-1.3-1.2-1.2-1.3-1.4-1.2-0.5-0.0
Length with tail0.52.03.2-1.8-1.81.81.6-1.6-1.5-1.4-1.4-1.2-1.4-1.5-1.31.21.5-1.5-1.4-1.3-1.4-1.5-1.2-0.70.1
Length without tail0.20.50.90.70.5-0.3-0.70.70.70.60.80.80.80.70.7-0.8-0.70.70.70.80.70.60.9-1.0-0.8
Times rat made contact with spout1.51.72.81.71.5-1.1-1.51.51.51.21.31.31.31.31.3-1.4-1.31.31.31.41.31.31.3-0.7-0.7
Lifetime Intake0.40.43.4-0.4-0.60.70.2-0.00.0-0.00.40.40.70.70.3-0.5-0.50.50.40.50.40.60.3-1.8-1.5
Liver weight, left0.30.54.9-0.9-1.11.20.6-0.5-0.4-0.50.00.00.20.3-0.1-0.10.1-0.1-0.00.00.1-0.10.0-2.2-1.5
Liver weight, right0.00.00.0-0.2-0.20.00.1-0.1-0.10.1-0.0-0.00.00.00.00.00.1-0.10.0-0.00.0-0.0-0.00.0-0.1
Locomotor activity0.10.20.40.70.6-0.5-0.60.60.50.50.50.50.40.40.5-0.5-0.60.60.40.50.40.50.4-0.0-0.1
Locomotor testing distance0.20.40.8-0.7-0.80.90.7-0.7-0.7-0.6-0.6-0.6-0.7-0.8-0.60.60.4-0.4-0.6-0.6-0.6-0.6-0.6-0.4-0.0
Locomotor testing rearing0.40.91.3-0.9-1.01.21.0-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.00.90.8-0.8-1.0-0.9-1.0-1.0-1.0-0.30.3
Locomotion in novel chamber0.20.20.7-0.4-0.30.10.4-0.4-0.4-0.4-0.4-0.6-0.4-0.4-0.50.60.4-0.4-0.4-0.6-0.6-0.4-0.60.80.7
Locomotion in novel chamber post-restriction0.40.73.1-0.6-0.4-0.10.6-0.6-0.6-0.4-0.7-0.9-0.8-0.7-0.70.90.8-0.8-0.7-0.8-0.8-0.8-0.71.81.2
Fecal boli incidents, locomotor time 10.00.00.1-0.3-0.30.20.1-0.1-0.10.1-0.00.1-0.3-0.2-0.0-0.10.1-0.1-0.00.10.0-0.10.1-0.2-0.3
Change in fecal boli incidents, locomotor task1.11.11.80.80.6-0.6-0.90.90.90.91.21.11.31.21.0-1.1-1.31.31.11.01.01.31.0-0.8-1.0
Time >=10cm from walls, locomotor time 10.40.50.9-0.2-0.20.50.5-0.5-0.6-0.9-0.9-0.8-0.6-0.5-0.70.70.8-0.8-0.8-0.7-0.7-0.8-0.70.30.8
Bouts of movement, locomotor time 10.20.20.5-0.3-0.20.20.4-0.4-0.4-0.4-0.6-0.4-0.7-0.7-0.50.40.4-0.4-0.5-0.4-0.3-0.5-0.40.60.6
Total resting periods, locomotor time 10.10.10.4-0.00.0-0.10.1-0.2-0.2-0.1-0.4-0.2-0.6-0.5-0.30.30.2-0.2-0.3-0.2-0.1-0.3-0.20.60.5
Rest time, locomotor task time 10.81.01.6-1.3-1.10.71.1-1.1-1.1-0.6-0.9-0.9-1.2-1.3-0.91.00.9-0.9-0.9-1.0-1.0-1.0-1.00.90.6
Distance moved, locomotor task time 10.20.31.1-0.3-0.40.80.5-0.5-0.5-1.0-0.6-0.7-0.3-0.3-0.60.70.6-0.6-0.6-0.7-0.5-0.5-0.6-0.70.1
Vertical activity count, locomotor time 10.00.00.10.40.3-0.1-0.10.10.1-0.3-0.1-0.20.10.2-0.10.10.1-0.1-0.1-0.2-0.1-0.1-0.10.20.4
Time >=10cm from walls, locomotor time 20.00.00.2-0.1-0.10.20.1-0.0-0.00.1-0.10.1-0.1-0.10.0-0.1-0.00.0-0.00.10.1-0.00.1-0.5-0.3
Bouts of movement, locomotor time 20.00.10.30.50.5-0.5-0.40.30.30.20.00.10.10.20.1-0.2-0.10.10.10.10.10.10.10.50.4
Total resting periods, locomotor time 20.00.10.20.30.4-0.4-0.30.20.20.20.10.10.10.20.1-0.2-0.10.10.10.20.10.10.10.50.3
Rest time, locomotor task time 21.41.82.2-1.4-1.30.91.4-1.4-1.4-1.1-1.3-1.4-1.4-1.5-1.41.41.4-1.4-1.3-1.3-1.5-1.4-1.41.11.1
Distance moved, locomotor task time 20.40.51.80.40.20.0-0.50.50.60.40.80.70.70.70.7-0.6-0.70.70.70.60.80.70.7-1.3-1.1
Vertical activity count, locomotor time 20.10.20.4-0.6-0.70.60.5-0.5-0.5-0.4-0.3-0.2-0.4-0.3-0.30.30.2-0.2-0.3-0.3-0.2-0.3-0.3-0.5-0.3
Light reinforcement 10.81.95.9-2.3-2.42.31.7-1.6-1.5-1.2-0.8-0.7-1.0-0.9-0.90.80.9-0.9-0.9-0.8-0.8-0.9-0.8-2.3-1.4
Light reinforcement 22.74.15.7-2.4-2.32.12.3-2.3-2.2-2.2-2.1-2.1-2.0-1.8-2.12.12.1-2.1-2.0-2.1-2.0-1.9-2.00.10.8
Bone: marrow area0.20.54.40.60.8-0.9-0.30.20.10.1-0.4-0.4-0.5-0.5-0.30.40.5-0.5-0.3-0.4-0.4-0.4-0.42.11.7
Bone: maximum diameter1.01.94.51.92.0-2.1-1.71.61.61.61.21.21.21.21.3-1.2-1.11.11.21.21.11.11.11.50.5
Bone: maximum force4.88.510.33.02.9-3.0-3.13.13.13.23.13.13.13.13.0-3.0-3.03.03.03.03.03.02.9-0.0-1.4
Bone: maximum moment4.27.49.42.82.8-2.9-2.92.92.93.12.92.92.82.82.9-2.8-2.82.82.82.82.82.82.70.2-1.2
Mean time between licks in bursts1.22.98.2-2.4-2.62.92.2-2.1-2.0-1.3-0.9-1.0-1.3-1.3-1.61.41.3-1.3-1.5-1.4-1.3-1.3-1.4-2.3-1.0
Mean num. licks in bursts0.71.13.00.70.5-0.2-0.80.90.90.40.91.01.00.91.1-1.1-1.11.11.01.11.21.21.2-1.7-1.5
Cd content in liver3.94.47.4-1.2-1.00.81.6-1.8-1.8-1.7-2.3-2.3-2.4-2.5-2.12.22.2-2.2-2.2-2.3-2.2-2.2-2.22.52.7
Co content in liver0.10.20.91.00.9-0.5-0.60.50.50.00.10.10.30.20.2-0.2-0.20.20.10.20.20.20.20.10.4
Cu content in liver2.73.24.12.02.0-1.8-2.02.01.91.91.91.81.81.81.8-1.8-1.81.81.81.81.81.81.8-0.1-0.7
Fe content in liver0.00.00.20.20.20.1-0.10.10.1-0.10.10.1-0.0-0.10.1-0.1-0.10.10.00.10.10.10.1-0.4-0.1
K content in liver10.610.212.22.92.6-2.5-3.13.23.33.23.43.53.43.53.4-3.4-3.43.43.33.43.43.43.4-1.9-2.7
Mg content in liver6.87.08.02.72.6-2.5-2.82.82.82.82.82.82.82.72.8-2.7-2.72.72.72.82.72.72.7-0.8-1.6
Mn content in liver0.10.10.30.20.1-0.1-0.20.30.30.20.30.30.30.40.3-0.3-0.30.30.30.30.30.30.3-0.5-0.4
Na content in liver5.96.48.12.01.8-1.7-2.32.42.42.52.82.92.62.72.6-2.8-2.82.82.72.82.82.82.8-1.9-2.5
Rb content in liver0.60.71.3-1.0-1.01.11.0-1.0-0.9-1.0-0.8-0.8-0.7-0.7-0.80.70.7-0.7-0.8-0.7-0.7-0.7-0.7-0.5-0.0
Se content in liver0.00.00.50.10.10.2-0.10.10.1-0.2-0.00.0-0.00.20.1-0.1-0.10.10.00.10.10.10.1-0.7-0.3
Sr content in liver0.60.50.60.70.6-0.4-0.70.70.70.60.70.70.70.70.7-0.7-0.70.70.70.70.70.70.7-0.7-0.7
Zn content in liver3.03.36.12.52.4-2.2-2.22.12.11.81.71.71.71.71.8-1.7-1.71.71.71.71.71.71.70.5-0.1
Bone: minimum diameter1.93.56.22.22.3-2.5-2.22.12.12.21.81.81.71.81.9-1.7-1.71.71.81.71.71.71.71.1-0.0
Time in familiar zone, hab. session 11.41.42.00.90.9-0.9-1.11.11.21.31.41.41.21.11.2-1.3-1.31.31.31.31.31.31.3-0.7-1.0
Time in novel zone, hab. session 10.40.40.7-0.8-0.80.80.8-0.8-0.7-0.8-0.7-0.7-0.6-0.6-0.70.70.6-0.6-0.6-0.7-0.6-0.6-0.7-0.10.1
Total zone transitions, hab. session 10.40.51.30.40.3-0.2-0.60.60.60.50.70.70.80.80.7-0.8-0.80.80.70.80.80.80.8-1.1-1.0
Total locomotion distance, hab. session 10.40.50.90.50.4-0.5-0.60.70.70.70.90.80.90.90.8-0.8-0.80.80.80.80.80.80.8-0.7-0.8
Locomotion velocity, hab. session 10.20.30.50.40.3-0.3-0.50.50.50.40.60.50.70.70.5-0.5-0.50.50.60.50.50.50.5-0.4-0.5
Time in familiar zone, hab. session 20.00.00.1-0.2-0.10.10.1-0.0-0.00.10.10.10.10.10.1-0.0-0.10.10.10.00.10.10.0-0.2-0.2
Time in novel zone, hab. session 20.00.10.10.00.0-0.0-0.10.10.20.20.20.30.10.20.2-0.3-0.20.20.20.30.20.20.3-0.4-0.4
Total zone transitions, hab. session 22.43.19.31.00.7-0.3-1.31.41.51.11.81.82.02.01.7-1.9-1.81.81.71.91.81.81.9-3.0-2.6
Total locomotion distance, hab. session 21.92.55.50.90.6-0.4-1.11.31.31.21.81.71.82.01.6-1.7-1.61.61.61.71.61.61.7-2.3-2.2
Locomotion velocity, hab. session 21.62.23.81.00.7-0.6-1.21.31.31.11.71.61.71.91.5-1.6-1.51.51.51.61.51.51.6-1.9-1.9
Novel to familiar place preference ratio1.01.02.01.31.4-1.4-1.21.21.21.00.90.91.01.01.0-0.9-0.90.91.00.90.90.90.90.70.1
Novelty place preference1.61.72.81.61.7-1.6-1.51.51.51.41.21.31.31.31.3-1.2-1.31.31.31.21.31.31.20.5-0.2
Time in novel zone, NPP test2.62.83.21.71.8-1.8-1.81.81.81.81.71.71.81.71.7-1.7-1.71.71.71.71.71.71.70.2-0.7
Total zone transitions, NPP test4.76.713.51.10.8-0.8-1.82.02.12.32.92.92.82.82.6-2.8-2.82.82.72.82.82.82.8-3.5-3.7
Total locomotion distance, NPP test1.92.64.80.80.6-0.6-1.21.31.41.51.91.81.71.81.7-1.8-1.71.71.71.81.71.71.8-2.1-2.2
Locomotion velocity, NPP test1.01.43.50.30.2-0.2-0.70.90.91.01.41.31.31.41.2-1.3-1.21.21.21.31.21.21.3-1.9-1.8
Intraocular pressure1.01.52.20.90.8-0.6-1.11.11.11.01.41.31.51.41.2-1.3-1.41.41.21.21.31.31.2-1.4-1.4
Delta distance traveled before/after self-admin1.51.63.0-1.7-1.71.71.5-1.5-1.4-1.6-1.2-1.3-0.9-1.0-1.21.21.1-1.1-1.2-1.2-1.3-1.1-1.1-0.7-0.1
Delta ambulatory time before/after self-admin1.51.93.6-1.9-1.81.81.7-1.6-1.6-1.5-1.3-1.4-1.1-1.2-1.31.41.2-1.2-1.3-1.3-1.4-1.2-1.2-0.50.0
Parametrial fat weight0.30.77.60.40.6-1.1-0.20.10.00.0-0.3-0.60.00.0-0.20.60.2-0.2-0.3-0.6-0.6-0.4-0.52.71.8
Pavlov. Cond. lever latency2.02.64.0-1.3-1.11.01.4-1.5-1.6-1.4-1.8-1.7-2.0-2.0-1.71.71.7-1.7-1.7-1.7-1.7-1.7-1.71.41.6
Pavlov. Cond. magazine entry latency1.31.72.8-1.6-1.61.71.5-1.5-1.4-1.6-1.3-1.3-1.1-1.0-1.31.21.2-1.2-1.3-1.2-1.2-1.2-1.2-0.60.1
Pavlov. Cond. change in total contacts0.50.51.1-0.8-0.91.10.8-0.8-0.8-1.0-0.7-0.7-0.4-0.3-0.70.60.7-0.7-0.7-0.6-0.7-0.7-0.6-0.7-0.2
Pavlov. Cond. index score0.20.21.8-0.5-0.60.70.3-0.2-0.2-0.30.20.10.40.40.1-0.1-0.10.10.10.10.10.10.1-1.3-1.0
Pavlov. Cond. latency score0.20.21.00.0-0.10.2-0.10.20.20.10.50.30.60.70.3-0.4-0.30.30.40.40.30.30.4-1.0-0.8
Pavlov. Cond. lever contacts1.61.93.40.90.6-0.5-1.11.11.21.01.51.41.71.81.4-1.4-1.41.41.41.41.41.41.4-1.8-1.8
Pavlov. Cond. magazine entry number1.31.63.11.61.7-1.8-1.51.51.41.61.21.21.00.91.2-1.2-1.11.11.21.21.11.11.20.90.2
Pavlov. Cond. intertrial magazine entries1.31.54.5-2.1-2.12.01.7-1.5-1.4-1.1-0.8-0.7-1.0-1.0-1.00.80.8-0.8-0.9-0.8-0.8-0.8-0.8-1.6-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.22.0-0.5-0.60.60.2-0.1-0.1-0.20.30.20.50.50.2-0.2-0.20.20.20.20.20.20.2-1.4-1.1
Pavlov. Cond. response bias0.30.43.4-0.8-1.01.10.6-0.5-0.4-0.6-0.1-0.10.20.2-0.20.10.1-0.1-0.1-0.1-0.1-0.1-0.1-1.8-1.2
Pavlov. Cond. lever latency4.56.18.8-3.0-3.03.02.8-2.8-2.7-2.8-2.5-2.5-2.4-2.4-2.52.42.4-2.4-2.4-2.3-2.4-2.4-2.4-0.80.5
Pavlov. Cond. magazine entry latency0.70.81.20.90.8-0.6-0.90.90.90.81.00.91.11.00.9-0.9-1.01.00.90.91.01.01.0-0.7-0.8
Pavlov. Cond. change in total contacts4.16.57.92.72.7-2.6-2.82.82.82.82.72.72.62.52.7-2.6-2.62.62.62.62.72.72.7-0.2-1.3
Pavlov. Cond. index score4.25.66.82.62.6-2.5-2.62.62.62.52.52.42.42.42.4-2.4-2.42.42.42.42.42.42.4-0.1-1.0
Pavlov. Cond. latency score3.95.16.62.62.5-2.4-2.52.52.52.42.42.32.32.32.3-2.3-2.32.32.32.22.32.32.3-0.0-0.9
Pavlov. Cond. lever contacts5.57.610.73.23.3-3.3-3.13.13.03.12.82.82.72.72.8-2.6-2.72.72.72.62.72.72.70.9-0.6
Pavlov. Cond. magazine entry number0.60.71.0-0.8-0.70.50.8-0.8-0.8-0.7-0.9-0.9-1.0-0.9-0.80.90.9-0.9-0.8-0.9-0.9-0.9-0.90.70.8
Pavlov. Cond. intertrial magazine entries0.71.06.3-1.7-1.91.71.1-0.9-0.8-0.6-0.0-0.0-0.00.0-0.20.00.1-0.1-0.1-0.0-0.1-0.1-0.0-2.5-2.0
Pavlov. Cond. lever-magazine prob. diff.4.15.46.42.52.5-2.4-2.52.52.52.52.52.42.52.42.4-2.3-2.42.42.42.32.42.42.4-0.2-1.1
Pavlov. Cond. response bias4.05.56.72.62.6-2.6-2.62.62.52.62.42.42.42.42.4-2.3-2.42.42.42.32.42.42.40.2-0.9
Time in closed arm before self-admin0.20.30.6-0.5-0.30.40.5-0.5-0.5-0.6-0.8-0.5-0.3-0.5-0.50.40.6-0.6-0.5-0.3-0.6-0.7-0.50.40.4
Time in closed arm after self-admin0.70.71.5-1.2-1.10.91.1-1.0-1.0-1.0-0.8-0.9-0.7-0.6-0.90.90.5-0.5-0.8-0.9-0.9-0.7-0.90.10.2
Time in open arm before self-admin1.01.11.81.10.9-0.7-1.01.11.11.11.31.10.81.21.1-1.0-1.01.01.10.91.21.11.0-0.8-0.9
Time in open arm after self-admin0.20.20.50.70.7-0.6-0.60.60.50.50.40.40.40.30.4-0.4-0.20.20.40.40.40.40.40.20.1
Bone: periosteal estimation1.32.75.12.02.1-2.3-1.91.91.82.01.61.61.51.51.6-1.5-1.51.51.61.51.51.51.51.10.1
Bone: periosteal perimeter0.50.81.30.90.9-1.1-0.91.00.91.10.90.90.90.90.9-0.9-0.90.90.90.90.90.90.90.5-0.2
Bone: post-yield work1.31.93.61.81.9-1.9-1.71.61.61.61.31.31.21.21.3-1.2-1.31.31.31.21.21.21.21.00.2
Progressive ratio test 1 active lever presses0.60.71.9-1.3-1.41.21.2-1.1-1.0-1.0-0.8-0.7-0.5-0.5-0.80.70.6-0.6-0.7-0.7-0.8-0.7-0.8-0.7-0.4
Progressive ratio test 1 breakpoint0.60.81.8-1.3-1.31.21.2-1.1-1.0-1.0-0.8-0.8-0.5-0.5-0.80.70.7-0.7-0.8-0.7-0.8-0.7-0.9-0.6-0.2
Progressive ratio test 1 inactive lever presses0.40.51.1-0.4-0.30.20.5-0.6-0.6-0.5-0.8-0.8-0.9-0.9-0.70.80.7-0.7-0.7-0.8-0.9-0.7-0.81.01.0
Progressive ratio test 2 active lever presses0.10.10.5-0.3-0.30.20.1-0.00.00.10.20.20.40.40.2-0.3-0.20.20.20.30.20.30.1-0.7-0.7
Progressive ratio test 2 breakpoint0.10.10.4-0.2-0.20.10.00.00.10.10.30.20.40.40.2-0.3-0.20.20.30.30.20.40.1-0.6-0.6
Progressive ratio test 2 inactive lever presses0.30.50.70.50.5-0.5-0.60.70.70.80.80.80.80.80.8-0.8-0.70.70.80.80.80.80.7-0.5-0.7
Incentive Sensitization - Responses0.00.00.3-0.6-0.50.30.3-0.3-0.2-0.0-0.1-0.0-0.1-0.1-0.10.00.2-0.2-0.0-0.0-0.1-0.0-0.2-0.2-0.3
Incentive Sensitization - Breakpoint0.00.10.3-0.5-0.50.30.3-0.2-0.20.00.00.10.00.00.0-0.10.1-0.10.00.1-0.00.0-0.1-0.4-0.5
Sum of active levers in priming session hrs 5-60.20.20.40.0-0.00.10.2-0.2-0.3-0.6-0.5-0.6-0.2-0.1-0.40.60.4-0.4-0.4-0.5-0.5-0.2-0.40.50.7
Progressive ratio1.21.92.9-1.5-1.51.71.6-1.6-1.5-1.6-1.5-1.4-1.4-1.4-1.41.41.3-1.3-1.4-1.3-1.3-1.4-1.3-0.60.3
Food seeking constrained by brief footshock3.44.111.6-3.0-3.23.42.5-2.3-2.2-2.3-1.5-1.4-1.3-1.3-1.61.31.3-1.3-1.5-1.4-1.4-1.2-1.3-3.3-1.7
Seeking ratio, punishment vs. effort0.40.61.70.2-0.00.0-0.40.50.50.50.90.80.80.90.7-0.8-0.90.90.70.70.70.90.7-1.3-1.3
Retroperitoneal fat weight0.62.723.72.02.4-2.4-1.20.90.70.3-0.7-0.7-0.2-0.3-0.20.60.6-0.6-0.3-0.6-0.4-0.4-0.54.93.7
Reaction time number correct0.40.71.90.30.1-0.1-0.50.60.60.60.91.00.90.90.8-1.0-1.01.00.81.00.90.90.9-1.4-1.3
Reaction time mean minus median0.00.00.4-0.1-0.0-0.3-0.0-0.0-0.00.30.00.0-0.2-0.2-0.10.10.2-0.2-0.0-0.1-0.3-0.2-0.20.60.4
Reaction time mean minus median AUC0.20.51.0-1.0-1.00.60.8-0.8-0.8-0.4-0.6-0.6-0.9-0.8-0.70.70.8-0.8-0.7-0.7-0.9-0.8-0.80.40.3
Reaction time num false alarms0.40.63.20.70.8-0.4-0.1-0.0-0.1-0.4-0.8-0.8-0.7-0.9-0.60.70.7-0.7-0.7-0.7-0.7-0.6-0.71.61.8
Reaction time num false alarms AUC0.30.52.60.60.7-0.4-0.1-0.0-0.1-0.3-0.7-0.7-0.7-1.0-0.50.60.6-0.6-0.6-0.6-0.6-0.6-0.61.41.6
Reaction time trials correct on left0.40.71.90.30.1-0.1-0.50.60.60.60.91.00.90.90.8-1.0-1.01.00.81.00.90.90.9-1.4-1.3
Reaction time trials on left0.40.71.90.30.2-0.1-0.50.60.60.60.91.00.90.90.8-1.0-1.01.00.81.00.90.90.9-1.4-1.3
Reaction time mean1.32.03.2-1.1-0.90.81.3-1.3-1.4-1.1-1.5-1.4-1.8-1.8-1.51.41.6-1.6-1.5-1.4-1.5-1.6-1.51.11.5
Reaction time mean AUC1.42.23.4-1.1-1.00.91.3-1.4-1.4-1.2-1.6-1.5-1.9-1.8-1.61.51.7-1.7-1.6-1.5-1.6-1.6-1.61.21.6
Median of all reaction times2.23.14.6-1.3-1.21.11.6-1.7-1.7-1.5-1.9-1.8-2.1-2.1-1.91.82.0-2.0-1.9-1.8-1.8-1.9-1.91.31.8
Reaction time omissions0.20.20.40.40.4-0.4-0.40.50.50.60.60.60.40.50.5-0.6-0.50.50.50.60.50.50.4-0.1-0.4
Reaction time false alarm rate0.81.15.30.60.8-0.6-0.1-0.1-0.2-0.4-0.9-1.0-0.9-1.2-0.71.00.9-0.9-0.9-1.0-0.9-0.9-0.92.32.3
Reaction time premature initiation rate4.56.27.62.72.5-2.3-2.72.72.72.52.62.62.72.82.6-2.5-2.52.52.62.52.52.52.5-0.8-1.5
Reaction time premature initiations3.76.58.32.32.1-1.9-2.52.62.62.42.72.82.82.92.7-2.7-2.72.72.72.72.72.62.7-1.7-2.3
Std. dev. reaction times0.30.61.0-0.5-0.50.40.6-0.7-0.7-0.5-0.8-0.8-1.0-1.0-0.80.80.8-0.8-0.8-0.8-0.9-0.9-0.90.80.9
Reaction time trials completed0.40.71.90.30.2-0.1-0.50.60.60.60.91.00.90.90.8-1.0-1.01.00.81.00.90.90.9-1.4-1.3
Reaction time trials AUC0.40.71.70.30.2-0.1-0.50.60.60.60.91.00.90.90.8-1.0-1.01.00.81.00.90.90.9-1.3-1.3
Run reversals in cocaine runway, females0.40.40.90.70.8-1.0-0.70.70.70.80.70.70.50.50.6-0.6-0.70.70.60.40.60.70.40.60.1
Run reversals in cocaine runway, males0.10.11.0-0.10.1-0.20.1-0.1-0.1-0.1-0.4-0.2-0.3-0.3-0.20.20.4-0.4-0.2-0.2-0.2-0.3-0.21.00.6
Latency to leave start box in cocaine runway0.10.21.20.20.3-0.3-0.0-0.0-0.1-0.2-0.2-0.5-0.2-0.2-0.30.40.1-0.1-0.3-0.5-0.4-0.1-0.51.10.9
Latency to leave start box in cocaine runway, F0.10.10.50.70.7-0.6-0.40.40.30.10.1-0.10.10.10.1-0.0-0.10.10.1-0.1-0.00.2-0.10.70.7
Latency to leave start box in cocaine runway, M0.40.40.7-0.6-0.60.40.7-0.6-0.7-0.8-0.5-0.9-0.5-0.4-0.70.80.5-0.5-0.6-0.8-0.8-0.5-0.80.70.6
Std. dev. time between licks in bursts2.02.73.61.21.0-0.9-1.41.51.51.61.91.91.81.81.7-1.8-1.81.81.71.81.81.81.7-1.4-1.8
Total sessions with >9 infusions0.20.30.7-0.7-0.80.80.7-0.6-0.6-0.8-0.5-0.4-0.1-0.1-0.40.30.3-0.3-0.4-0.3-0.3-0.3-0.5-0.7-0.4
Short access day 1 total inactive lever presses0.00.00.1-0.3-0.40.10.1-0.1-0.1-0.1-0.1-0.10.10.10.00.10.1-0.10.0-0.1-0.1-0.1-0.1-0.2-0.2
Short access day 10 total inactive lever presses0.51.12.21.41.4-1.5-1.31.31.21.21.00.91.01.01.1-0.9-0.90.91.00.91.00.81.00.70.1
Short access day 1 total infusions0.50.71.7-1.1-1.21.31.0-1.0-0.9-1.1-0.7-0.8-0.4-0.4-0.70.70.7-0.7-0.7-0.7-0.7-0.6-0.8-1.0-0.4
Short access day 10 total infusions0.10.10.4-0.6-0.60.60.4-0.4-0.4-0.3-0.2-0.2-0.1-0.1-0.20.20.2-0.2-0.2-0.2-0.3-0.2-0.3-0.6-0.4
Short access total infusions0.20.21.2-0.7-0.80.90.6-0.5-0.5-0.6-0.2-0.3-0.0-0.0-0.30.20.1-0.1-0.3-0.2-0.2-0.1-0.3-1.1-0.7
Short access day 1 locomotion0.00.00.1-0.0-0.10.10.1-0.1-0.1-0.3-0.1-0.20.10.1-0.10.2-0.10.1-0.1-0.2-0.10.1-0.3-0.00.0
Short access day 10 total locomotion0.30.53.61.11.3-1.1-0.70.50.50.2-0.3-0.2-0.1-0.10.00.10.1-0.1-0.1-0.1-0.2-0.2-0.11.91.6
Short access total locomotion0.00.00.10.20.10.0-0.0-0.0-0.0-0.3-0.1-0.20.10.1-0.10.2-0.20.2-0.1-0.2-0.10.2-0.30.10.2
One hour access (0.3 mA shock)0.50.63.5-0.2-0.40.3-0.20.30.40.40.70.80.80.80.7-0.8-0.60.60.70.80.80.70.6-1.9-1.7
Compulsive drug intake0.40.54.40.20.4-0.7-0.1-0.0-0.10.1-0.6-0.4-0.8-0.8-0.30.40.7-0.7-0.4-0.4-0.4-0.7-0.42.11.5
One hour access (shock baseline)0.40.76.4-0.9-1.21.30.6-0.4-0.4-0.40.20.20.40.40.0-0.2-0.20.20.10.20.10.30.0-2.5-1.8
Social response proportion0.70.82.1-1.4-1.30.61.1-1.0-1.0-0.4-0.8-0.7-1.2-1.1-0.80.70.9-0.9-0.8-0.7-0.8-0.9-0.80.90.5
Social responses1.51.93.9-2.0-1.91.71.7-1.6-1.6-1.2-1.2-1.1-1.6-1.5-1.31.21.3-1.3-1.2-1.2-1.2-1.3-1.2-0.5-0.1
Social time1.01.43.1-1.8-1.71.41.5-1.4-1.4-0.9-1.1-0.9-1.3-1.3-1.10.91.2-1.2-1.0-0.9-1.1-1.3-0.9-0.3-0.1
Soleus weight0.41.22.01.41.3-1.0-1.31.21.21.01.11.11.01.01.0-1.1-1.01.01.01.11.11.11.1-0.5-0.5
Bone: stiffness8.013.116.63.33.2-3.5-3.63.73.74.14.04.03.93.93.8-3.8-3.83.83.83.83.83.83.8-0.5-2.3
Tibialis anterior weight1.24.012.82.62.9-3.4-2.42.22.12.61.51.51.10.91.6-1.3-1.41.41.51.31.41.41.43.61.6
Time to tail flick, vehicle, before self-admin0.20.20.4-0.4-0.50.60.5-0.5-0.5-0.7-0.4-0.5-0.4-0.3-0.40.50.3-0.3-0.5-0.5-0.5-0.4-0.5-0.5-0.0
Time to tail flick, vehicle, after self-admin1.11.42.0-1.3-1.31.31.3-1.3-1.3-1.2-1.2-1.1-1.3-1.3-1.21.01.4-1.4-1.2-1.0-1.1-1.3-1.1-0.00.4
Time to tail flick, test, before self-admin5.75.98.0-2.8-2.72.42.7-2.7-2.6-2.5-2.6-2.5-2.4-2.2-2.42.52.6-2.6-2.4-2.5-2.5-2.6-2.40.41.0
Time to tail flick, test, after self-admin0.20.20.5-0.0-0.0-0.1-0.20.30.30.50.50.40.50.60.5-0.4-0.30.30.50.40.30.30.5-0.5-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.2-0.1-0.10.00.00.00.30.10.30.10.00.1-0.30.1-0.10.20.30.2-0.10.20.2-0.2
Delta time to tail flick, test, before/after SA2.72.83.71.71.7-1.8-1.81.81.81.91.81.81.71.61.7-1.7-1.71.71.71.71.71.71.7-0.0-0.8
Tibia length3.49.411.82.62.3-2.1-2.93.03.03.13.43.43.33.43.2-3.3-3.23.23.23.33.23.23.3-2.2-2.8
Ambulatory time before self-admin0.20.31.1-0.0-0.10.50.4-0.5-0.5-1.0-0.9-0.8-0.4-0.4-0.70.60.5-0.5-0.7-0.7-0.5-0.4-0.70.20.7
Ambulatory time after self-admin1.61.93.7-1.1-1.11.51.4-1.4-1.4-1.9-1.7-1.7-1.1-1.4-1.51.51.3-1.3-1.5-1.5-1.3-1.1-1.50.00.8
Bone: tissue strength1.51.52.01.31.4-1.4-1.31.31.31.41.31.31.21.21.3-1.2-1.31.31.31.21.31.31.20.2-0.5
Total heroin consumption0.20.31.21.11.0-0.7-0.60.50.5-0.0-0.1-0.00.40.40.1-0.10.0-0.00.10.10.30.10.00.90.9
Bone: trabecular number0.81.311.7-1.1-1.41.60.6-0.4-0.3-0.30.50.50.40.40.2-0.5-0.50.50.30.50.50.50.5-3.4-2.6
Bone: trabecular spacing0.70.92.61.51.6-1.5-1.21.11.10.90.70.60.80.80.8-0.6-0.60.60.70.60.60.60.61.30.7
Bone: trabecular thickness0.20.20.7-0.8-0.80.80.6-0.5-0.5-0.3-0.2-0.2-0.3-0.2-0.30.20.2-0.2-0.2-0.2-0.2-0.2-0.2-0.8-0.6
Bone: trabecular tissue density0.60.91.7-1.3-1.31.11.2-1.1-1.1-1.0-1.0-0.9-0.8-0.8-0.90.90.9-0.9-0.9-0.9-0.9-0.9-0.9-0.10.1
Water consumed over 24 hours1.92.63.61.61.4-1.3-1.61.61.61.91.91.91.61.71.6-1.6-1.61.61.61.61.71.71.7-0.9-1.2
Number of responses in last shaping day0.00.00.10.0-0.00.1-0.0-0.0-0.00.0-0.0-0.1-0.1-0.10.00.10.1-0.1-0.1-0.1-0.3-0.00.0-0.2-0.0