Fmnl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Fmnl2	0.27	0.22	0.0e+00	0.22	0.23	0.23	0.22	3.9e-23	8.3e-25	2.4e-25	4.9e-24
2	PL	isoform ratio	XM_008761822.4	0.04	0.04	2.3e-04	0.04	0.03	0.04	0.04	1.6e-05	3.5e-04	3.3e-05	2.7e-05
3	pVTA	gene expression	Fmnl2	0.11	0.11	7.0e-06	0.05	0.03	0.04	0.05	6.1e-05	2.3e-03	3.9e-04	3.6e-05
4	Brain	mRNA stability	Fmnl2	0.04	0.04	1.0e-03	0.03	0.02	0.03	0.03	5.8e-04	3.3e-03	8.0e-04	9.7e-04
5	IC	gene expression	Fmnl2	0.32	0.17	1.9e-11	0.18	0.19	0.2	0.18	4.8e-08	2.5e-08	1.2e-08	3.4e-08
6	PL	isoform ratio	XM_039106789.2	0.03	0.03	1.4e-03	0.03	0.02	0.03	0.03	6.8e-04	1.4e-03	3.4e-04	5.6e-04
7	Brain	gene expression	Fmnl2	0.24	0.16	0.0e+00	0.2	0.22	0.22	0.22	7.9e-19	4.9e-20	7.5e-20	7.3e-20
8	BLA	gene expression	Fmnl2	0.31	0.2	7.2e-16	0.22	0.28	0.22	0.27	8.0e-12	3.8e-15	9.7e-12	1.0e-14
9	OFC	gene expression	Fmnl2	0.31	0.2	1.2e-04	0.09	0.1	0.1	0.09	4.4e-03	2.1e-03	3.0e-03	4.8e-03
10	NAcc	gene expression	Fmnl2	0.17	0.12	0.0e+00	0.17	0.19	0.18	0.18	1.1e-24	2.2e-27	1.9e-26	2.7e-26
11	IL	gene expression	Fmnl2	0.21	0.17	1.0e-03	0.11	0.11	0.11	0.1	1.2e-03	1.6e-03	1.5e-03	2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.6	1.1	1.4	1.2	-1.0	-1.0	-1.0	1.1	1.1	-1.0	-1.0	-1.0	-1.0	1.1
Area under the delay curve	2.5	3.9	5.1	1.7	-1.9	-2.3	-2.0	2.2	2.1	-1.9	-1.9	-1.9	-1.9	1.8
BMI with tail	0.0	0.1	0.5	-0.2	0.7	-0.2	0.2	0.0	-0.3	-0.3	-0.3	-0.3	-0.3	0.6
BMI without tail	0.1	0.4	0.6	-0.6	0.8	0.6	0.7	-0.7	-0.7	0.6	0.6	0.6	0.6	-0.5
Body weight	0.2	0.7	3.0	0.1	1.7	0.5	0.9	-1.2	-1.3	0.5	0.4	0.5	0.5	-0.4
Weight adjusted by age	0.1	0.4	1.0	0.3	-0.9	-1.0	-0.7	0.6	0.6	-0.4	-0.4	-0.4	-0.4	0.6
Bone surface	0.0	0.0	0.2	0.4	-0.2	-0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.2	-0.2	0.3
Bone volume	0.5	0.9	1.4	1.2	-0.9	-1.0	-0.9	0.9	0.9	-0.9	-0.9	-0.9	-0.9	1.0
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	-0.1	-0.0	0.2	0.2	0.2	0.2	-0.2
Number of licking bursts	0.6	1.8	3.4	1.9	-1.3	-1.3	-1.3	1.0	1.2	-1.3	-1.4	-1.3	-1.3	1.3
Context. condit. distance diff. score	0.1	0.1	0.2	0.1	-0.2	-0.0	-0.2	0.3	0.3	-0.3	-0.3	-0.3	-0.3	0.4
Locomotion velocity, session 1	0.0	0.0	0.1	0.2	0.2	-0.1	0.2	-0.2	-0.2	0.1	0.1	0.1	0.1	-0.1
Locomotion distance, session 1	0.4	0.4	0.7	-0.7	0.6	0.8	0.6	-0.6	-0.7	0.6	0.6	0.7	0.7	-0.7
Locomotion velocity, session 2	0.5	0.7	2.5	1.6	-0.7	-1.0	-0.7	0.5	0.5	-0.7	-0.7	-0.7	-0.7	0.7
Locomotion distance, session 2	0.6	0.9	2.3	-1.5	0.8	0.8	0.8	-0.7	-0.8	0.9	0.9	0.9	0.9	-1.0
Locomotion velocity, session 3	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.3	0.1	0.2	-0.3	-0.3	-0.3	-0.3	0.3
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.2	-0.2	0.2	0.2	0.2	0.2	-0.1
Stereotopy head waving bouts, day 3	1.1	1.3	2.3	-1.5	1.1	0.9	1.1	-1.0	-1.1	1.1	1.1	1.1	1.1	-1.1
Stereotopy head waving duration, day 3	2.1	2.6	3.8	-1.9	1.6	1.3	1.6	-1.6	-1.6	1.6	1.6	1.6	1.6	-1.6
Locomotion velocity, session 7	2.1	2.3	3.6	-1.9	1.4	1.7	1.5	-1.5	-1.4	1.5	1.5	1.5	1.5	-1.4
Locomotion distance, session 7	0.6	0.8	1.1	-0.2	0.9	1.1	0.9	-1.1	-0.9	0.9	0.8	0.9	0.9	-0.8
Stereotopy head waving bouts, day 7	0.2	0.3	2.7	-1.6	0.2	0.2	0.2	0.1	-0.1	0.2	0.2	0.2	0.2	-0.2
Stereotopy head waving duration, day 7	0.2	0.2	1.0	-1.0	-0.4	-0.2	-0.4	0.6	0.4	-0.3	-0.3	-0.3	-0.3	0.2
Locomotion velocity, session 8	0.1	0.1	0.5	-0.7	0.2	0.2	0.2	-0.1	-0.1	0.2	0.2	0.2	0.2	-0.2
Locomotion distance, session 8	0.3	0.4	1.0	-1.0	0.6	0.9	0.6	-0.5	-0.5	0.6	0.6	0.6	0.6	-0.5
Degree of sensitization distance	0.2	0.2	0.3	0.3	0.4	0.5	0.4	-0.6	-0.5	0.4	0.4	0.4	0.4	-0.4
Degree of sensitization stereotypy	0.3	0.3	0.5	-0.3	-0.6	-0.5	-0.6	0.7	0.6	-0.6	-0.6	-0.6	-0.6	0.6
Conditioned locomotion	0.1	0.1	0.9	-1.0	-0.1	-0.1	-0.1	0.6	0.4	-0.1	-0.0	-0.1	-0.1	0.0
Cocaine response after cond. corrected	0.2	0.3	0.5	0.1	-0.6	-0.6	-0.6	0.7	0.6	-0.6	-0.6	-0.6	-0.6	0.6
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.2	-0.2	0.2	0.2	0.2	0.2	-0.2
Cocaine response before conditioning	1.0	1.2	2.1	0.0	1.1	1.2	1.1	-1.5	-1.3	1.1	1.0	1.1	1.1	-1.1
Saline control response	0.0	0.0	0.1	0.2	0.2	0.3	0.2	-0.2	-0.2	0.2	0.2	0.2	0.2	-0.2
Bone: connectivity density	0.0	0.1	0.2	0.1	-0.2	-0.2	-0.2	0.4	0.3	-0.2	-0.2	-0.2	-0.2	0.3
Bone: cortical apparent density	0.0	0.0	0.1	0.0	-0.2	-0.3	-0.2	0.1	0.1	-0.2	-0.2	-0.2	-0.2	0.2
Bone: cortical area	1.3	2.1	2.5	-0.8	1.5	1.6	1.5	-1.6	-1.5	1.5	1.5	1.5	1.5	-1.4
Bone: cortical porosity	0.5	0.5	0.6	0.5	-0.8	-0.6	-0.8	0.7	0.8	-0.8	-0.8	-0.8	-0.8	0.7
Bone: cortical porosity	0.3	0.4	0.5	0.4	-0.7	-0.5	-0.7	0.6	0.6	-0.7	-0.7	-0.7	-0.7	0.6
Bone: cortical thickness	1.2	1.9	2.8	-0.7	1.4	1.4	1.4	-1.7	-1.6	1.4	1.4	1.4	1.4	-1.3
Bone: cortical thickness	1.1	1.4	2.4	-0.4	1.2	1.3	1.2	-1.5	-1.3	1.2	1.1	1.2	1.2	-1.0
Bone: cortical tissue density	0.1	0.1	0.2	0.2	-0.3	-0.5	-0.3	0.2	0.2	-0.3	-0.3	-0.3	-0.3	0.3
Condit. Reinf. active minus inactive responses	2.1	2.4	3.7	-1.9	1.5	1.5	1.5	-1.4	-1.5	1.5	1.6	1.5	1.5	-1.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.2	-1.5	1.0	1.3	1.1	-0.9	-1.0	1.1	1.1	1.1	1.1	-1.1
Condit. Reinf. active responses	1.8	2.4	3.7	-1.9	1.5	1.5	1.5	-1.4	-1.4	1.5	1.6	1.5	1.5	-1.5
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	0.4	0.2	0.4	-0.5	-0.5	0.4	0.4	0.4	0.4	-0.4
Incentive salience index mean	2.3	2.9	4.2	-2.0	1.7	1.7	1.7	-1.6	-1.6	1.7	1.7	1.7	1.7	-1.7
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.6	0.7	0.6	0.7	-0.6	-0.6	0.6	0.7	0.6	0.6	-0.6
Condit. Reinf. active minus inactive responses	4.2	6.5	8.3	-2.2	2.5	2.9	2.5	-2.6	-2.6	2.5	2.5	2.5	2.5	-2.5
Condit. Reinf. active-inactive response ratio	5.1	8.1	8.2	-2.8	2.9	2.8	2.9	-2.9	-2.9	2.9	2.8	2.9	2.8	-2.8
Condit. Reinf. active responses	2.5	3.6	5.3	-1.5	1.9	2.3	1.9	-2.1	-2.0	1.9	1.8	1.9	1.9	-1.8
Condit. Reinf. inactive responses	0.5	0.7	1.0	1.0	-0.9	-0.5	-0.9	0.7	0.8	-0.9	-0.9	-0.9	-0.9	0.9
Condit. Reinf. lever presses	0.6	0.9	1.4	-1.0	0.9	1.2	0.9	-0.7	-0.8	0.9	1.0	0.9	0.9	-0.9
Condit. Reinf. lever reinforcers received	2.9	4.1	5.9	-1.7	2.0	2.4	2.0	-2.1	-2.1	2.0	2.0	2.0	2.0	-2.0
Conditioned reinforcement - actives	0.1	0.6	0.9	-0.7	0.6	0.5	0.3	-0.8	-0.6	0.9	0.9	0.9	0.9	-0.9
Conditioned reinforcement - inactives	0.3	0.9	1.3	-0.9	1.1	0.7	0.4	-0.8	-0.9	1.0	1.0	1.0	1.0	-1.0
Conditioned locomotion	0.1	0.2	0.6	0.6	-0.3	-0.5	-0.7	0.3	0.4	-0.3	-0.3	-0.3	-0.3	0.2
Patch foraging indifference point 0 sec	0.1	0.3	0.6	0.8	-0.3	-0.3	-0.2	0.3	0.2	-0.7	-0.7	-0.7	-0.7	0.3
Patch foraging indifference point AUC	1.5	3.6	5.4	-2.3	1.8	2.2	1.6	-1.7	-1.7	1.9	1.9	1.9	1.9	-1.9
Delay disc. indifference point, 0s delay	3.3	3.7	4.3	1.9	-2.0	-2.0	-1.9	2.1	2.1	-1.9	-1.8	-1.9	-1.9	1.8
Delay disc. indifference point, 16s delay	2.2	3.1	4.2	1.7	-1.4	-2.1	-1.8	1.9	1.7	-1.8	-1.8	-1.8	-1.8	1.7
Delay disc. indifference point, 2s delay	4.8	5.3	6.1	1.9	-2.1	-2.4	-2.1	2.5	2.3	-2.4	-2.4	-2.4	-2.4	2.2
Delay disc. indifference point, 24s delay	0.9	1.5	2.0	1.1	-1.2	-1.4	-1.2	1.3	1.3	-1.1	-1.2	-1.1	-1.2	1.2
Delay disc. indifference point, 4s delay	3.7	3.9	4.7	1.9	-2.1	-2.0	-2.2	2.1	2.1	-1.9	-1.9	-1.9	-1.9	1.8
Delay disc. indifference point, 8s delay	1.0	1.6	2.6	1.0	-1.3	-1.6	-1.2	1.3	1.3	-1.2	-1.2	-1.2	-1.2	1.2
Indifference point function ln k	0.2	0.5	0.7	0.7	-0.8	-0.7	-0.7	0.8	0.8	-0.7	-0.7	-0.7	-0.7	0.7
Indifference point function log k	0.2	0.5	0.7	0.7	-0.8	-0.7	-0.7	0.8	0.8	-0.7	-0.7	-0.7	-0.7	0.7
Patch foraging total patch changes 0 sec	0.2	0.4	0.9	0.9	-0.5	-0.5	-0.4	0.5	0.4	-0.8	-0.8	-0.8	-0.8	0.5
Patch foraging total patch changes 12 sec	0.6	0.9	1.7	-1.1	1.2	0.7	1.2	-1.0	-1.3	0.6	0.6	0.6	0.6	-0.9
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.0	-0.2	0.0	-0.1	0.3	0.2	-0.3	-0.3	-0.3	-0.3	0.0
Patch foraging total patch changes 24 sec	0.3	1.1	2.4	-1.2	0.9	1.5	0.8	-1.0	-1.0	0.9	0.9	0.9	1.0	-1.2
Patch foraging total patch changes 6 sec	0.2	0.4	1.1	0.7	-0.7	-0.2	-1.0	0.7	0.7	-0.5	-0.5	-0.5	-0.5	0.1
Patch foraging time to switch 0 sec	0.8	2.9	3.9	1.7	-1.6	-2.0	-1.4	1.7	1.6	-1.7	-1.7	-1.7	-1.7	1.7
Patch foraging water rate 0 sec	0.4	1.4	2.5	-1.2	1.0	1.6	0.7	-1.1	-1.0	1.2	1.2	1.2	1.2	-1.3
Patch foraging water rate 12 sec	0.6	2.5	3.8	-1.7	1.1	2.0	0.8	-1.3	-1.0	1.8	1.8	1.8	1.8	-1.9
Patch foraging water rate 18 sec	0.4	0.8	1.1	-0.6	0.8	1.1	0.5	-0.9	-0.8	1.0	1.0	1.0	1.0	-1.0
Patch foraging water rate 24 sec	0.4	0.6	0.9	-0.4	0.5	1.0	-0.0	-0.7	-0.5	0.9	0.9	0.9	0.9	-0.8
Patch foraging water rate 6 sec	1.1	1.6	2.4	-1.3	1.2	1.6	1.4	-1.2	-1.1	1.2	1.2	1.2	1.2	-1.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.3	0.2	0.3	-0.3	-0.3	-0.3	-0.3	0.4
Distance traveled before self-admin	0.1	0.2	0.4	-0.6	0.1	0.1	0.2	-0.4	-0.3	0.6	0.6	0.6	0.6	-0.7
Distance traveled after self-admin	0.1	0.2	0.5	-0.7	-0.4	0.2	-0.1	-0.2	0.1	0.6	0.6	0.6	0.6	-0.5
Extensor digitorum longus weight	0.7	2.7	3.0	-1.4	1.7	1.7	1.7	-1.7	-1.7	1.6	1.6	1.6	1.6	-1.4
Bone: elastic displacement	1.2	1.5	1.9	-1.3	1.2	1.4	1.2	-1.1	-1.1	1.2	1.2	1.2	1.2	-1.2
Bone: elastic work	3.0	4.0	5.1	-1.9	2.0	2.2	2.0	-1.9	-1.9	2.0	2.0	2.0	2.0	-1.9
Bone: endosteal estimation	0.0	0.1	0.3	-0.4	0.2	0.5	0.2	0.1	-0.0	0.3	0.3	0.3	0.3	-0.3
Bone: endosteal perimeter	0.2	0.6	1.3	-0.5	0.7	1.1	0.7	-0.6	-0.6	0.8	0.8	0.8	0.8	-0.7
Epididymis fat weight	0.1	0.5	1.2	-0.5	1.1	0.5	1.1	-0.9	-1.0	0.5	0.4	0.5	0.5	-0.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.0	0.2	0.2	-0.2	-0.2	-0.2	-0.2	0.2
Delta time in open arm before/after self-admin	0.4	0.5	0.8	-0.6	0.3	0.9	0.4	-0.6	-0.4	0.8	0.8	0.8	0.8	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.3	0.1	0.1	-0.2	-0.2	-0.2	-0.2	0.2
Delay discount exponential model param	2.4	3.3	4.4	-1.5	1.7	2.1	1.8	-2.0	-1.9	1.8	1.7	1.8	1.8	-1.7
Extinction: sum of active levers before priming	0.3	0.4	1.1	0.6	-1.0	-0.9	-1.0	0.6	0.8	-0.3	-0.3	-0.3	-0.3	0.3
Active lever presses in extinction session 6	0.1	0.1	0.2	0.0	-0.4	-0.4	-0.4	0.2	0.2	-0.1	-0.1	-0.1	-0.1	0.1
Bone: final force	2.2	3.6	4.0	-1.3	2.0	1.9	2.0	-1.9	-1.9	2.0	1.9	2.0	2.0	-1.9
Bone: final moment	1.8	2.8	3.4	-1.0	1.7	1.8	1.7	-1.7	-1.7	1.7	1.7	1.7	1.7	-1.7
Food consumed during 24 hour testing period	0.0	0.1	0.2	-0.3	0.3	0.4	0.3	-0.3	-0.2	0.3	0.3	0.3	0.3	-0.3
Glucose	0.1	0.2	0.4	-0.1	-0.6	0.5	-0.2	-0.1	0.2	0.5	0.4	0.5	0.5	-0.4
Heart weight	2.7	4.3	5.7	2.3	-1.7	-2.4	-1.5	1.6	1.5	-2.3	-2.4	-2.3	-2.3	2.1
Delay discount hyperbolic model param	2.9	3.8	4.8	-1.7	1.9	2.2	2.0	-2.1	-2.0	1.9	1.9	1.9	1.9	-1.8
Intermittent access intake day 1-15 change	0.1	0.7	1.7	0.9	-1.1	-0.3	-1.3	0.9	1.1	-0.7	-0.7	-0.7	-0.7	0.7
Intermittent access intake escalation	0.2	1.2	2.3	1.2	-1.3	-0.6	-1.5	1.2	1.3	-1.0	-1.0	-1.0	-1.0	1.0
Intermittent access intake escalation 2	0.2	0.3	0.7	0.6	-0.5	-0.2	-0.8	0.6	0.6	-0.4	-0.4	-0.4	-0.4	0.5
Intermitt. access day 1 inactive lever presses	0.1	1.8	2.6	-1.4	1.6	0.9	1.6	-1.3	-1.4	1.3	1.3	1.3	1.3	-1.2
Intermitt. access day 15 inactive lever presses	1.5	7.9	8.7	-2.9	2.8	2.5	2.5	-2.8	-2.7	2.9	3.0	2.9	2.9	-2.9
Intermitt. access escalation Index	0.1	0.5	0.9	0.6	-0.0	-0.9	-0.3	0.6	0.3	-0.8	-0.8	-0.8	-0.8	0.8
Intermittent access day 1 total infusions	0.4	1.2	1.6	-1.1	1.3	0.7	1.0	-1.2	-1.2	1.1	1.1	1.1	1.1	-1.1
Intermittent access day 15 total infusions	0.0	0.0	0.2	0.2	0.1	0.0	-0.4	0.1	0.1	0.1	0.1	0.1	0.1	-0.0
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.6	-0.5	0.5	0.8	0.2	-0.5	-0.4	0.8	0.8	0.8	0.8	-0.7
Intermittent access total infusions	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1	-0.2	-0.1	0.3	0.3	0.3	0.3	-0.2
Intermittent access day 1 locomotion	0.2	0.3	0.6	-0.6	0.6	0.3	0.4	-0.6	-0.5	0.6	0.7	0.6	0.6	-0.7
Intermittent access day 15 total locomotion	0.1	0.3	0.5	-0.6	0.2	0.6	0.3	-0.5	-0.3	0.7	0.7	0.7	0.7	-0.7
Intermittent access total locomotion	0.1	0.2	0.3	-0.4	0.1	0.5	0.1	-0.4	-0.2	0.5	0.5	0.5	0.5	-0.5
Intermittent access standard deviation	0.1	0.4	1.3	-0.5	0.6	1.1	0.1	-0.5	-0.4	0.7	0.7	0.7	0.7	-0.7
Left kidney weight	0.2	1.4	2.6	-0.7	1.6	1.3	1.0	-1.3	-1.2	1.2	1.2	1.2	1.2	-1.0
Right kidney weight	0.1	0.4	0.7	-0.0	0.8	0.8	0.2	-0.7	-0.6	0.7	0.7	0.7	0.7	-0.6
Cocaine induced anxiety	1.4	3.7	4.6	-1.7	2.1	2.2	2.1	-2.0	-2.0	1.9	1.8	1.8	1.8	-1.7
Post-drug Anxiety	1.9	2.2	3.7	-1.4	1.9	1.1	1.7	-1.6	-1.7	1.4	1.4	1.4	1.4	-1.3
Baseline Anxiety	2.6	4.3	8.1	1.8	-1.7	-2.8	-1.9	2.1	1.9	-2.1	-2.1	-2.1	-2.1	2.0
Tail length	0.2	1.2	1.8	-0.6	0.7	1.2	0.9	-1.3	-1.0	1.2	1.2	1.2	1.2	-1.3
Length with tail	0.5	2.1	5.5	-0.4	2.3	1.0	1.7	-1.9	-2.1	1.1	1.0	1.0	1.0	-1.3
Length without tail	0.3	1.7	4.8	-0.7	2.2	1.1	1.4	-1.5	-1.8	1.1	1.0	1.1	1.0	-1.1
Times rat made contact with spout	0.3	0.4	0.5	-0.5	0.6	0.5	0.6	-0.7	-0.6	0.6	0.6	0.6	0.6	-0.6
Lifetime Intake	0.0	0.0	0.1	0.1	0.0	0.0	-0.3	0.1	0.1	0.0	0.0	0.0	0.0	-0.0
Liver weight, left	1.4	2.4	4.5	-2.1	1.6	1.5	1.2	-1.4	-1.4	1.5	1.5	1.5	1.5	-1.6
Liver weight, right	0.3	0.4	1.4	0.3	1.2	-0.3	0.9	-0.8	-1.1	-0.3	-0.4	-0.3	-0.3	0.3
Locomotor activity	1.1	1.7	3.1	-1.2	1.0	1.5	0.5	-1.2	-1.0	1.5	1.5	1.5	1.5	-1.8
Locomotor testing distance	1.3	3.1	4.0	-1.4	1.7	2.0	1.7	-2.0	-1.8	1.7	1.7	1.7	1.7	-1.9
Locomotor testing rearing	2.9	10.5	12.3	-3.1	3.3	3.3	3.5	-3.4	-3.4	3.1	3.1	3.1	3.1	-3.3
Locomotion in novel chamber	0.0	0.0	0.1	0.3	-0.3	-0.1	0.1	0.1	0.2	-0.1	-0.2	-0.2	-0.2	0.1
Locomotion in novel chamber post-restriction	0.7	2.2	3.5	1.4	-1.3	-1.6	-1.9	1.6	1.5	-1.4	-1.4	-1.4	-1.4	1.5
Fecal boli incidents, locomotor time 1	0.3	0.7	2.5	-0.8	1.6	0.8	0.7	-0.8	-1.0	0.7	0.6	0.7	0.7	-0.4
Change in fecal boli incidents, locomotor task	1.4	1.5	2.4	1.1	-1.5	-1.3	-0.7	1.1	1.1	-1.3	-1.3	-1.3	-1.3	0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	0.0	-0.2	0.1	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1	0.2
Bouts of movement, locomotor time 1	0.6	0.7	1.7	1.3	-0.6	-0.3	-1.1	0.9	0.9	-0.8	-0.8	-0.8	-0.8	0.9
Total resting periods, locomotor time 1	1.0	1.2	2.5	1.6	-0.7	-0.5	-1.3	1.1	1.0	-1.0	-1.1	-1.1	-1.0	1.1
Rest time, locomotor task time 1	1.3	2.1	3.5	1.9	-0.8	-1.4	-1.0	1.2	0.9	-1.6	-1.7	-1.7	-1.7	1.6
Distance moved, locomotor task time 1	0.7	2.1	3.3	-1.6	0.8	1.5	1.0	-1.2	-1.0	1.6	1.6	1.6	1.6	-1.8
Vertical activity count, locomotor time 1	0.1	0.9	1.4	-1.2	1.0	0.6	0.9	-0.9	-0.9	0.9	0.9	0.9	0.9	-1.0
Time >=10cm from walls, locomotor time 2	0.6	1.8	2.4	-1.2	1.5	1.0	1.2	-1.5	-1.5	1.3	1.4	1.3	1.3	-1.4
Bouts of movement, locomotor time 2	2.0	6.7	7.8	2.7	-2.7	-2.4	-2.6	2.5	2.6	-2.5	-2.5	-2.5	-2.5	2.8
Total resting periods, locomotor time 2	1.4	5.8	7.4	2.6	-2.4	-2.3	-2.3	2.2	2.3	-2.4	-2.4	-2.4	-2.4	2.7
Rest time, locomotor task time 2	1.4	2.3	3.0	1.5	-1.5	-1.4	-1.5	1.4	1.4	-1.5	-1.6	-1.5	-1.5	1.7
Distance moved, locomotor task time 2	3.6	4.8	6.1	-2.3	1.7	2.4	1.8	-2.0	-1.8	2.3	2.4	2.3	2.3	-2.5
Vertical activity count, locomotor time 2	0.2	0.5	0.8	-0.7	0.9	0.6	0.7	-0.8	-0.7	0.7	0.7	0.7	0.7	-0.7
Light reinforcement 1	0.1	0.6	1.1	-0.3	0.9	0.8	0.9	-1.1	-1.0	0.6	0.6	0.6	0.6	-0.8
Light reinforcement 2	0.1	0.3	0.7	-0.3	0.3	0.8	-0.1	-0.4	-0.3	0.7	0.7	0.7	0.7	-0.9
Bone: marrow area	0.0	0.1	0.3	-0.5	0.2	0.5	0.2	0.0	-0.0	0.3	0.3	0.3	0.3	-0.3
Bone: maximum diameter	0.2	0.4	0.6	-0.7	0.6	0.7	0.6	-0.4	-0.5	0.6	0.6	0.6	0.6	-0.6
Bone: maximum force	1.3	2.6	2.9	-1.1	1.7	1.7	1.7	-1.6	-1.6	1.7	1.6	1.7	1.6	-1.6
Bone: maximum moment	0.9	1.8	2.5	-0.8	1.4	1.6	1.4	-1.4	-1.3	1.4	1.3	1.4	1.3	-1.3
Mean time between licks in bursts	0.1	0.5	1.4	-1.2	0.6	1.0	0.6	-0.4	-0.5	0.6	0.7	0.6	0.6	-0.6
Mean num. licks in bursts	1.2	3.1	4.3	-2.1	1.8	1.7	1.8	-1.5	-1.6	1.8	1.8	1.8	1.8	-1.8
Cd content in liver	0.1	0.1	0.5	0.7	-0.0	0.2	0.0	-0.4	-0.2	0.0	-0.0	0.0	0.0	-0.0
Co content in liver	0.1	0.1	0.3	0.6	-0.5	-0.1	-0.5	0.3	0.4	-0.4	-0.4	-0.4	-0.4	0.2
Cu content in liver	0.3	0.4	1.7	1.3	-0.5	-0.6	-0.5	-0.1	0.2	-0.5	-0.5	-0.5	-0.5	0.4
Fe content in liver	1.3	1.6	2.2	1.3	-1.5	-0.9	-1.5	1.1	1.3	-1.3	-1.3	-1.3	-1.3	1.0
K content in liver	0.3	0.3	0.4	0.6	-0.6	-0.6	-0.6	0.5	0.6	-0.6	-0.6	-0.6	-0.6	0.5
Mg content in liver	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.4	0.3	0.4	-0.3	-0.3	-0.3	-0.3	0.1
Mn content in liver	0.3	0.3	0.5	-0.7	0.5	0.7	0.5	-0.4	-0.5	0.5	0.5	0.5	0.5	-0.4
Na content in liver	1.9	2.2	2.9	-1.7	1.4	1.3	1.4	-1.4	-1.4	1.5	1.5	1.5	1.5	-1.7
Rb content in liver	0.2	0.2	0.2	0.4	-0.5	-0.4	-0.5	0.4	0.5	-0.4	-0.4	-0.4	-0.4	0.3
Se content in liver	0.8	0.9	2.5	1.6	-0.9	-0.9	-0.9	0.5	0.7	-0.9	-1.0	-0.9	-1.0	0.9
Sr content in liver	0.9	0.8	1.3	1.1	-0.8	-0.9	-0.8	0.8	0.8	-0.8	-0.8	-0.8	-0.8	0.8
Zn content in liver	0.8	0.9	2.2	1.5	-1.0	-1.0	-1.0	0.6	0.8	-1.0	-1.0	-0.9	-0.9	0.7
Bone: minimum diameter	0.0	0.0	0.2	0.0	0.1	0.4	0.1	0.1	0.0	0.1	0.1	0.1	0.1	-0.1
Time in familiar zone, hab. session 1	0.5	0.6	2.5	-1.6	0.6	0.5	0.6	-0.4	-0.5	0.6	0.7	0.6	0.7	-0.7
Time in novel zone, hab. session 1	1.0	1.1	4.2	2.0	-1.0	-0.9	-1.0	0.6	0.7	-1.0	-1.0	-1.0	-1.0	1.0
Total zone transitions, hab. session 1	0.3	0.5	0.9	-0.9	0.6	0.8	0.6	-0.6	-0.7	0.7	0.7	0.7	0.7	-0.6
Total locomotion distance, hab. session 1	0.8	1.1	1.7	-1.3	1.0	1.1	1.0	-0.9	-1.0	1.0	1.0	1.0	1.0	-1.0
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.8	0.7	0.8	0.7	-0.6	-0.6	0.7	0.6	0.6	0.6	-0.6
Time in familiar zone, hab. session 2	0.5	0.5	0.7	0.6	-0.8	-0.7	-0.8	0.8	0.8	-0.8	-0.7	-0.8	-0.7	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.2	0.4	0.0	0.1	0.0	-0.2	-0.1	0.0	0.0	0.0	0.0	-0.0
Total zone transitions, hab. session 2	2.8	3.6	4.5	-2.1	1.8	2.1	1.8	-1.8	-1.8	1.8	1.9	1.8	1.9	-1.9
Total locomotion distance, hab. session 2	0.2	0.3	0.6	-0.6	0.5	0.8	0.5	-0.6	-0.5	0.5	0.6	0.5	0.6	-0.6
Locomotion velocity, hab. session 2	0.6	0.8	1.1	-1.1	0.8	1.1	0.8	-0.8	-0.8	0.9	0.9	0.9	0.9	-0.9
Novel to familiar place preference ratio	0.1	0.1	0.7	-0.8	0.3	0.0	0.2	-0.1	-0.1	0.2	0.3	0.2	0.2	-0.3
Novelty place preference	0.1	0.1	0.7	-0.8	0.2	-0.1	0.2	-0.0	-0.1	0.2	0.2	0.2	0.2	-0.2
Time in novel zone, NPP test	0.0	0.0	0.3	-0.5	-0.0	-0.3	-0.0	0.2	0.1	-0.0	0.0	-0.0	-0.0	-0.0
Total zone transitions, NPP test	0.1	0.1	0.3	0.2	0.3	0.6	0.3	-0.5	-0.5	0.3	0.3	0.3	0.3	-0.3
Total locomotion distance, NPP test	0.1	0.2	0.5	0.2	0.4	0.7	0.4	-0.6	-0.5	0.4	0.4	0.4	0.4	-0.3
Locomotion velocity, NPP test	0.2	0.3	0.6	-0.1	0.6	0.8	0.6	-0.7	-0.6	0.6	0.5	0.5	0.5	-0.5
Intraocular pressure	1.7	2.8	3.3	-1.7	1.7	1.7	1.8	-1.8	-1.7	1.6	1.5	1.6	1.6	-1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.1	0.2	0.2	-0.1	-0.1	-0.1	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.1	0.1	0.2	0.2	-0.0	-0.1	0.0	0.0	0.0	0.0	0.0
Parametrial fat weight	0.1	0.3	0.8	-0.4	0.9	0.6	0.2	-0.6	-0.6	0.6	0.6	0.6	0.6	-0.6
Pavlov. Cond. lever latency	0.7	0.8	2.3	1.5	-0.8	-0.9	-0.8	0.6	0.6	-0.9	-0.9	-0.9	-0.9	0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.4	0.6	-0.1	-0.1	-0.1	-0.2	-0.0	-0.0	-0.0	-0.0	-0.0	-0.0
Pavlov. Cond. change in total contacts	3.4	3.6	5.1	-2.3	1.9	1.9	1.9	-1.8	-1.8	1.9	1.9	1.9	1.9	-1.9
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.5	-0.4	0.5	0.5	0.5	0.5	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.9	0.6	0.6	0.6	-0.5	-0.5	0.6	0.6	0.6	0.6	-0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.9	-1.0	0.4	0.6	0.4	-0.2	-0.2	0.4	0.4	0.4	0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.3	-0.2	-0.1	-0.2	0.4	0.3	-0.2	-0.2	-0.2	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.2	-0.4	-0.0	0.2	-0.0	0.2	0.1	-0.0	0.0	-0.0	0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.8	0.7	0.7	0.7	-0.7	-0.6	0.7	0.7	0.7	0.7	-0.8
Pavlov. Cond. response bias	0.3	0.3	0.5	-0.1	0.6	0.5	0.6	-0.7	-0.6	0.6	0.6	0.6	0.6	-0.7
Pavlov. Cond. lever latency	0.8	1.1	1.6	1.2	-1.0	-1.3	-1.0	0.7	0.9	-1.0	-1.1	-1.0	-1.0	1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.1	-0.4	-0.2	-0.3	0.7	0.5	-0.3	-0.3	-0.3	-0.3	0.3
Pavlov. Cond. change in total contacts	0.6	1.6	2.2	-0.9	1.3	1.5	1.3	-1.2	-1.2	1.3	1.3	1.3	1.3	-1.3
Pavlov. Cond. index score	0.2	0.3	0.6	-0.7	0.5	0.8	0.5	-0.2	-0.4	0.6	0.6	0.6	0.6	-0.6
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.0	0.3	0.0	0.2	0.1	0.1	0.1	0.1	0.1	-0.1
Pavlov. Cond. lever contacts	1.1	1.6	2.3	-1.5	1.2	1.4	1.2	-0.9	-1.1	1.3	1.3	1.3	1.3	-1.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	0.5	-0.5	-0.8	-0.5	0.2	0.3	-0.6	-0.6	-0.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.5	0.7	-0.7	0.7	0.6	0.7	-0.8	-0.8	0.7	0.7	0.7	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	-0.6	0.5	0.7	0.5	-0.2	-0.4	0.5	0.6	0.5	0.6	-0.6
Pavlov. Cond. response bias	1.3	1.8	3.0	-1.7	1.3	1.6	1.3	-0.9	-1.1	1.3	1.4	1.3	1.4	-1.4
Time in closed arm before self-admin	0.5	1.0	1.4	1.2	-0.5	-0.7	-1.0	1.0	0.9	-1.1	-1.1	-1.1	-1.1	1.0
Time in closed arm after self-admin	2.0	2.3	2.8	1.5	-0.9	-1.5	-1.4	1.6	1.4	-1.7	-1.6	-1.7	-1.7	1.6
Time in open arm before self-admin	1.5	1.8	2.5	-1.6	0.9	0.5	1.3	-1.4	-1.3	1.4	1.5	1.5	1.4	-1.5
Time in open arm after self-admin	1.7	1.9	2.6	-1.5	0.6	1.3	1.1	-1.4	-1.1	1.6	1.6	1.6	1.6	-1.5
Bone: periosteal estimation	0.5	1.3	1.8	-0.9	1.2	1.4	1.2	-1.0	-1.0	1.2	1.2	1.2	1.2	-1.1
Bone: periosteal perimeter	0.5	1.0	1.7	-0.3	1.0	1.3	1.0	-0.9	-0.9	1.1	1.0	1.1	1.0	-1.0
Bone: post-yield work	0.3	0.6	1.8	1.4	-0.8	-0.4	-0.7	0.4	0.6	-0.7	-0.8	-0.7	-0.7	0.8
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	-0.7	1.0	0.4	0.7	-0.6	-0.7	0.6	0.6	0.6	0.6	-0.5
Progressive ratio test 1 breakpoint	0.3	0.5	1.1	-0.7	1.0	0.5	0.7	-0.6	-0.8	0.6	0.6	0.6	0.6	-0.5
Progressive ratio test 1 inactive lever presses	1.7	4.5	6.4	-2.3	2.5	1.8	2.2	-2.0	-2.2	2.0	2.1	2.0	2.0	-2.1
Progressive ratio test 2 active lever presses	0.9	1.3	1.6	-1.1	0.8	1.2	0.9	-1.1	-0.9	1.3	1.3	1.3	1.3	-1.3
Progressive ratio test 2 breakpoint	1.1	1.4	1.8	-1.2	0.9	1.3	0.9	-1.2	-1.0	1.3	1.3	1.3	1.3	-1.3
Progressive ratio test 2 inactive lever presses	0.3	1.1	1.3	-1.0	0.9	1.2	0.7	-0.9	-0.8	1.1	1.1	1.1	1.1	-1.1
Incentive Sensitization - Responses	0.5	1.2	2.1	-1.1	0.7	1.5	0.8	-1.0	-0.8	1.2	1.2	1.2	1.2	-1.3
Incentive Sensitization - Breakpoint	0.6	1.3	2.3	-1.1	0.6	1.5	0.8	-1.1	-0.9	1.3	1.3	1.3	1.3	-1.3
Sum of active levers in priming session hrs 5-6	1.3	1.2	2.9	1.0	-1.7	-1.1	-1.7	1.1	1.5	-0.6	-0.6	-0.6	-0.7	0.6
Progressive ratio	0.3	0.7	1.1	-0.8	1.1	0.9	0.5	-0.9	-0.9	0.9	0.9	0.9	0.9	-0.7
Food seeking constrained by brief footshock	11.0	13.8	17.4	-4.2	3.3	2.7	3.6	-3.7	-3.6	3.9	3.9	3.9	3.9	-4.0
Seeking ratio, punishment vs. effort	0.2	0.5	1.2	-0.9	0.3	0.2	1.1	-0.7	-0.6	0.6	0.6	0.6	0.6	-0.9
Retroperitoneal fat weight	0.2	1.0	1.7	-0.7	1.3	1.0	1.0	-1.1	-1.2	1.0	0.9	1.0	1.0	-1.0
Reaction time number correct	0.6	2.2	2.3	-1.5	1.5	1.5	1.5	-1.5	-1.5	1.5	1.5	1.5	1.5	-1.3
Reaction time mean minus median	0.1	0.6	1.3	1.1	-0.8	-0.9	-1.1	0.5	0.6	-0.5	-0.6	-0.5	-0.5	0.7
Reaction time mean minus median AUC	0.0	0.0	0.2	0.4	-0.0	-0.2	-0.2	-0.1	-0.1	-0.0	-0.1	-0.0	-0.0	0.1
Reaction time num false alarms	1.7	2.9	3.3	-1.5	1.6	1.7	1.2	-1.8	-1.7	1.8	1.8	1.8	1.8	-1.6
Reaction time num false alarms AUC	1.5	3.5	4.1	-1.7	1.8	1.8	1.5	-2.0	-1.9	2.0	2.0	2.0	2.0	-1.8
Reaction time trials correct on left	0.6	2.2	2.3	-1.5	1.5	1.5	1.5	-1.5	-1.5	1.5	1.5	1.5	1.5	-1.3
Reaction time trials on left	0.7	2.5	2.7	-1.6	1.6	1.6	1.5	-1.6	-1.6	1.6	1.6	1.6	1.6	-1.4
Reaction time mean	1.9	4.2	8.2	1.9	-2.4	-2.0	-2.9	2.2	2.4	-1.7	-1.6	-1.7	-1.7	1.6
Reaction time mean AUC	1.7	4.1	8.1	2.0	-2.4	-2.0	-2.8	2.2	2.3	-1.7	-1.6	-1.7	-1.7	1.6
Median of all reaction times	3.5	5.5	9.8	2.1	-2.7	-2.2	-3.1	2.6	2.7	-2.0	-2.0	-2.0	-2.0	1.9
Reaction time omissions	0.9	1.4	2.1	-1.5	1.3	0.8	1.1	-1.1	-1.3	1.2	1.2	1.2	1.2	-1.2
Reaction time false alarm rate	0.2	0.3	0.5	-0.4	0.4	0.5	0.1	-0.6	-0.5	0.7	0.7	0.7	0.7	-0.6
Reaction time premature initiation rate	0.3	0.4	0.9	1.0	-0.6	-0.3	-0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.7
Reaction time premature initiations	0.0	0.1	0.4	-0.0	0.3	0.6	0.5	-0.5	-0.4	0.3	0.2	0.3	0.3	-0.1
Std. dev. reaction times	0.3	1.0	1.9	1.1	-1.1	-1.1	-1.4	1.0	1.1	-0.8	-0.8	-0.8	-0.8	0.8
Reaction time trials completed	0.7	2.5	2.7	-1.6	1.6	1.6	1.5	-1.6	-1.6	1.6	1.6	1.6	1.6	-1.4
Reaction time trials AUC	0.8	2.6	2.9	-1.7	1.6	1.6	1.5	-1.6	-1.5	1.7	1.7	1.7	1.7	-1.5
Run reversals in cocaine runway, females	0.1	0.2	0.5	-0.1	0.7	0.4	0.4	-0.5	-0.7	0.2	0.1	0.2	0.2	0.0
Run reversals in cocaine runway, males	1.0	1.1	2.8	-0.7	1.7	0.7	1.4	-1.1	-1.3	0.7	0.7	0.7	0.7	-1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.2	0.1	0.2	0.5	-0.3	0.0	-0.0	0.0	0.0	0.0	0.0	-0.2
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	-0.6	0.5	0.6	0.4	-0.5	-0.5	0.6	0.6	0.6	0.6	-0.8
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.5	-0.6	-0.3	-0.9	0.7	0.7	-0.5	-0.5	-0.5	-0.5	0.5
Std. dev. time between licks in bursts	0.2	0.4	0.5	0.6	-0.7	-0.3	-0.7	0.6	0.6	-0.7	-0.7	-0.7	-0.7	0.7
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	0.1	0.1	-0.0	-0.0	-0.0	-0.0	0.0
Short access day 1 total inactive lever presses	0.4	0.9	1.2	-1.0	1.1	1.0	0.6	-0.8	-0.8	1.0	1.0	1.0	1.0	-0.9
Short access day 10 total inactive lever presses	0.3	1.8	2.6	-1.5	1.1	1.1	1.0	-1.2	-1.0	1.5	1.5	1.5	1.5	-1.6
Short access day 1 total infusions	0.7	1.4	1.7	-1.3	1.3	0.9	1.0	-1.2	-1.1	1.3	1.3	1.3	1.3	-1.3
Short access day 10 total infusions	0.1	0.2	0.3	0.6	-0.2	0.0	-0.5	0.4	0.4	-0.4	-0.4	-0.4	-0.4	0.5
Short access total infusions	0.0	0.0	0.1	0.2	0.1	-0.3	-0.3	0.2	0.1	-0.2	-0.1	-0.1	-0.2	0.1
Short access day 1 locomotion	0.6	1.0	1.7	-0.8	1.3	1.0	0.8	-1.1	-1.1	0.9	0.9	0.9	0.9	-1.0
Short access day 10 total locomotion	0.1	0.3	0.6	0.5	-0.8	-0.2	-0.5	0.5	0.6	-0.6	-0.5	-0.5	-0.5	0.3
Short access total locomotion	0.2	0.3	0.5	0.6	-0.3	-0.5	-0.7	0.5	0.5	-0.6	-0.6	-0.6	-0.6	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.4	0.1	0.5	0.2	-0.4	-0.2	0.5	0.5	0.5	0.5	-0.6
Compulsive drug intake	0.1	0.1	0.3	-0.5	0.1	-0.3	0.5	-0.3	-0.4	0.2	0.3	0.2	0.2	-0.4
One hour access (shock baseline)	0.1	0.2	0.5	0.6	-0.3	-0.0	-0.7	0.5	0.5	-0.4	-0.4	-0.4	-0.4	0.5
Social response proportion	0.2	0.2	0.8	-0.5	0.7	-0.2	0.9	-0.5	-0.8	-0.1	-0.1	-0.1	-0.1	0.1
Social responses	0.2	0.3	1.6	-0.5	0.8	0.1	1.3	-0.5	-0.8	-0.1	-0.1	-0.1	-0.1	0.1
Social time	6.9	10.8	14.9	-3.1	3.5	3.1	3.9	-3.4	-3.5	3.1	3.1	3.1	3.1	-3.0
Soleus weight	1.6	4.8	5.3	-1.8	2.3	2.3	2.3	-2.3	-2.3	2.2	2.2	2.2	2.2	-2.0
Bone: stiffness	0.9	1.6	1.8	-0.9	1.3	1.2	1.3	-1.2	-1.2	1.3	1.3	1.3	1.3	-1.3
Tibialis anterior weight	1.2	4.3	4.6	-1.9	2.2	2.2	2.2	-2.1	-2.1	2.1	2.1	2.1	2.1	-1.9
Time to tail flick, vehicle, before self-admin	3.0	3.7	4.6	-2.1	2.2	1.2	1.8	-1.9	-2.0	1.9	1.9	1.9	1.9	-2.0
Time to tail flick, vehicle, after self-admin	1.2	2.5	3.7	-1.6	1.7	1.3	1.9	-1.7	-1.8	1.5	1.4	1.5	1.5	-1.4
Time to tail flick, test, before self-admin	1.4	1.6	3.8	-1.5	1.9	0.6	1.7	-1.2	-1.5	1.0	1.0	1.0	1.0	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	0.7	0.6	-0.2	-0.8	-0.3	0.4	0.3	-0.6	-0.6	-0.6	-0.6	0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.5	-0.1	0.2	0.0	0.7	-0.3	-0.4	-0.2	-0.3	-0.2	-0.2	0.3
Delta time to tail flick, test, before/after SA	2.1	2.6	4.0	1.8	-2.0	-1.4	-1.7	1.4	1.7	-1.5	-1.5	-1.5	-1.5	1.6
Tibia length	1.1	3.2	3.5	-1.9	1.8	1.8	1.8	-1.7	-1.7	1.8	1.8	1.8	1.8	-1.8
Ambulatory time before self-admin	0.0	0.0	0.2	-0.2	-0.4	-0.0	-0.3	0.1	0.2	0.1	0.2	0.1	0.1	-0.2
Ambulatory time after self-admin	0.2	0.3	0.6	-0.8	0.2	0.6	0.3	-0.4	-0.3	0.7	0.7	0.7	0.7	-0.7
Bone: tissue strength	0.1	0.1	0.1	0.2	0.2	0.4	0.2	-0.3	-0.2	0.2	0.2	0.2	0.2	-0.3
Total heroin consumption	0.1	0.1	0.1	0.4	-0.2	-0.4	-0.4	0.2	0.1	-0.3	-0.3	-0.3	-0.3	0.3
Bone: trabecular number	0.0	0.1	0.2	0.5	-0.2	-0.4	-0.2	0.4	0.3	-0.2	-0.2	-0.2	-0.2	0.3
Bone: trabecular spacing	0.0	0.0	0.2	-0.3	0.2	0.4	0.2	-0.1	-0.2	0.2	0.2	0.2	0.2	-0.2
Bone: trabecular thickness	0.1	0.1	0.2	0.0	-0.3	-0.3	-0.3	0.5	0.4	-0.3	-0.3	-0.3	-0.3	0.3
Bone: trabecular tissue density	0.6	1.1	1.2	-1.1	1.1	0.8	1.1	-1.1	-1.0	1.1	1.1	1.1	1.1	-1.1
Water consumed over 24 hours	0.2	0.4	1.7	1.3	-0.6	-0.4	-0.6	0.4	0.5	-0.6	-0.6	-0.6	-0.6	0.6
Number of responses in last shaping day	0.2	0.2	0.8	-0.3	0.9	-0.0	0.3	-0.5	-0.6	0.5	0.4	0.5	0.4	-0.3