Flot2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Flot2	0.04	0.03	2.5e-06	0.02	0.03	0.02	0.03	1.6e-04	1.4e-05	1.4e-04	5.5e-05
2	Brain	mRNA stability	Flot2	0.08	0.07	2.4e-08	0.08	0.07	0.08	0.07	6.3e-08	1.9e-07	5.6e-08	1.8e-07
3	Adipose	gene expression	Flot2	0.07	0.07	6.3e-06	0.03	0.04	0.03	0.03	3.0e-04	8.6e-05	3.3e-04	2.9e-04
4	NAcc	gene expression	Flot2	0.01	0.01	8.4e-03	0.01	0.01	0.01	0.01	2.3e-02	2.1e-02	3.1e-02	3.8e-02
5	pVTA	mRNA stability	Flot2	0.03	0.03	2.9e-03	0.02	0.02	0.02	0.02	4.8e-03	8.8e-03	7.3e-03	7.5e-03
6	PL	mRNA stability	Flot2	0.04	0.03	2.2e-04	0.04	0.03	0.05	0.04	1.8e-05	5.6e-04	2.1e-06	3.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.9	3.6	4.0	-2.0	2.0	2.0	-2.0	2.0	1.3
Area under the delay curve	1.8	2.8	3.9	1.6	-1.6	-1.7	1.8	-2.0	-1.3
BMI with tail	1.5	5.3	6.3	-2.4	2.5	2.4	-2.4	2.5	1.5
BMI without tail	1.1	6.1	6.9	-2.6	2.6	2.6	-2.6	2.6	1.8
Body weight	2.2	9.4	11.6	-3.4	3.4	3.4	-3.3	3.2	0.7
Weight adjusted by age	0.3	0.8	4.0	-0.4	0.5	0.5	-0.5	0.2	2.0
Bone surface	1.5	3.0	3.0	-1.7	1.7	1.7	-1.7	1.7	1.7
Bone volume	1.2	2.4	2.6	-1.6	1.6	1.6	-1.6	1.6	1.2
Breakpoint value in progressive ratio session	0.7	1.2	3.4	-0.9	0.8	0.9	-1.0	0.8	1.9
Number of licking bursts	0.1	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.6	-0.0
Context. condit. distance diff. score	0.6	0.7	0.7	-0.8	0.8	0.8	-0.8	0.8	0.7
Locomotion velocity, session 1	1.8	2.0	2.4	-1.5	1.5	1.5	-1.5	1.5	0.6
Locomotion distance, session 1	0.2	0.3	0.4	-0.5	0.5	0.5	-0.5	0.3	-0.6
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	0.2	0.0
Locomotion distance, session 2	1.1	1.6	1.7	-1.3	1.3	1.3	-1.3	1.2	1.1
Locomotion velocity, session 3	2.6	3.0	3.8	1.9	-1.9	-1.9	1.9	-1.7	-0.6
Locomotion distance, session 3	0.4	0.5	0.6	0.7	-0.7	-0.7	0.7	-0.6	-0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.1	0.1	0.1	-0.2	0.2	0.6
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.7	-0.7	-0.6	0.6	-0.4	0.4
Locomotion velocity, session 7	0.4	0.4	0.6	-0.6	0.6	0.6	-0.7	0.8	0.5
Locomotion distance, session 7	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	0.9	0.4
Stereotopy head waving bouts, day 7	0.6	0.7	1.2	-0.8	0.8	0.8	-0.8	0.8	1.1
Stereotopy head waving duration, day 7	0.3	0.4	0.4	-0.6	0.6	0.6	-0.6	0.6	0.6
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.2	-0.0
Locomotion distance, session 8	0.7	1.1	1.2	-1.1	1.1	1.1	-1.1	1.0	0.8
Degree of sensitization distance	3.0	3.2	3.6	-1.9	1.9	1.9	-1.9	1.8	1.3
Degree of sensitization stereotypy	0.7	0.8	1.1	-0.8	0.9	0.8	-0.8	0.8	1.0
Conditioned locomotion	1.1	1.3	1.8	1.3	-1.3	-1.3	1.3	-1.0	0.2
Cocaine response after cond. corrected	1.4	2.1	2.8	-1.4	1.4	1.4	-1.4	1.5	1.7
Cocaine response after cond. not corrected	2.0	2.9	4.8	-1.6	1.6	1.6	-1.6	1.7	2.2
Cocaine response before conditioning	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	0.4	0.4
Saline control response	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.0	0.0	0.3
Bone: connectivity density	3.8	6.1	6.3	-2.5	2.5	2.5	-2.5	2.5	2.4
Bone: cortical apparent density	0.3	0.4	0.5	0.7	-0.7	-0.7	0.7	-0.5	-0.6
Bone: cortical area	1.6	2.6	4.1	1.5	-1.5	-1.5	1.5	-1.5	-2.0
Bone: cortical porosity	0.3	0.3	0.4	-0.6	0.5	0.5	-0.6	0.7	0.1
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4	0.4	0.0
Bone: cortical thickness	2.7	4.4	4.7	2.1	-2.1	-2.1	2.1	-2.0	-2.2
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2	0.0
Bone: cortical tissue density	0.1	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.3	-0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	0.9	-0.9	-0.9	0.8	-0.8	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	-0.4	-0.4	0.4	-0.4	-0.0
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.1	0.3
Condit. Reinf. inactive responses	0.3	0.4	0.4	-0.6	0.6	0.6	-0.6	0.6	0.7
Incentive salience index mean	0.2	0.3	0.3	0.6	-0.5	-0.6	0.6	-0.5	0.2
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.3	0.4	0.3	-0.3	0.4	0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	0.6	-0.5	-0.5	0.5	-0.4	0.5
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	0.8	-0.7	-0.8	0.7	-0.6	0.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.4	-0.4	0.3	-0.3	0.5
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.2	0.2	0.3	-0.3	0.2	0.3
Condit. Reinf. lever presses	2.1	3.0	3.5	1.9	-1.9	-1.9	1.8	-1.8	-1.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.5	0.7	-0.7	-0.7	0.6	-0.6	0.1
Conditioned reinforcement - actives	0.1	0.3	0.4	-0.6	0.6	0.5	-0.6	0.6	0.2
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.4	0.3	0.3	-0.3	0.2	-0.5
Conditioned locomotion	0.3	0.5	1.7	-0.5	0.5	0.4	-0.4	0.5	1.3
Patch foraging indifference point 0 sec	0.3	0.7	1.2	0.8	-0.8	-0.8	0.8	-0.9	-1.1
Patch foraging indifference point AUC	1.0	2.4	3.1	1.8	-1.7	-1.8	1.7	-1.4	-0.1
Delay disc. indifference point, 0s delay	1.5	1.7	4.1	1.0	-1.0	-1.0	1.1	-1.3	-2.0
Delay disc. indifference point, 16s delay	1.5	2.2	3.4	1.4	-1.3	-1.4	1.5	-1.8	-1.3
Delay disc. indifference point, 2s delay	2.9	3.3	4.3	1.8	-1.8	-1.8	1.8	-2.1	-1.6
Delay disc. indifference point, 24s delay	0.6	0.9	2.0	-0.8	0.8	0.8	-0.8	0.8	1.4
Delay disc. indifference point, 4s delay	0.7	0.7	2.6	0.5	-0.6	-0.5	0.6	-0.8	-1.6
Delay disc. indifference point, 8s delay	0.8	1.3	1.6	1.2	-1.1	-1.2	1.3	-1.3	0.6
Indifference point function ln k	0.2	0.7	0.9	-1.0	0.9	1.0	-1.0	0.5	-0.8
Indifference point function log k	0.2	0.7	0.9	-1.0	0.9	1.0	-1.0	0.5	-0.8
Patch foraging total patch changes 0 sec	0.2	0.5	0.8	0.7	-0.7	-0.6	0.6	-0.8	-0.9
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	0.5	-0.5	-0.5	0.5	-0.6	-0.7
Patch foraging total patch changes 18 sec	0.8	1.9	2.3	1.5	-1.5	-1.5	1.4	-1.4	-0.9
Patch foraging total patch changes 24 sec	0.7	2.3	3.0	1.7	-1.7	-1.7	1.7	-1.5	-0.4
Patch foraging total patch changes 6 sec	2.8	4.7	5.3	2.3	-2.2	-2.3	2.3	-2.1	-1.7
Patch foraging time to switch 0 sec	0.6	2.2	2.7	-1.6	1.5	1.6	-1.5	1.6	1.1
Patch foraging water rate 0 sec	0.8	3.0	3.5	1.7	-1.7	-1.7	1.7	-1.9	-1.7
Patch foraging water rate 12 sec	0.1	0.5	1.2	-0.6	0.6	0.6	-0.6	0.3	-1.1
Patch foraging water rate 18 sec	0.2	0.5	0.8	-0.8	0.9	0.8	-0.8	0.6	-0.2
Patch foraging water rate 24 sec	0.4	0.5	1.6	0.5	-0.5	-0.5	0.5	-0.8	-1.3
Patch foraging water rate 6 sec	1.2	1.7	2.9	1.2	-1.2	-1.2	1.2	-1.4	-1.7
Seeking ratio, delayed vs. immediate footshock	1.5	2.1	2.7	1.6	-1.5	-1.6	1.6	-1.4	-0.9
Distance traveled before self-admin	2.7	5.9	13.6	2.2	-2.1	-2.2	2.2	-1.8	-3.7
Distance traveled after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3	0.4	-0.1	0.3
Extensor digitorum longus weight	0.7	2.8	3.1	-1.7	1.8	1.7	-1.7	1.6	1.5
Bone: elastic displacement	2.7	3.4	3.7	1.9	-1.9	-1.9	1.9	-1.9	-1.7
Bone: elastic work	8.6	11.2	12.2	3.3	-3.4	-3.3	3.3	-3.3	-3.5
Bone: endosteal estimation	0.1	0.1	0.6	0.1	-0.1	-0.2	0.2	-0.4	-0.8
Bone: endosteal perimeter	0.0	0.1	0.3	-0.1	0.1	0.0	0.0	-0.1	-0.6
Epididymis fat weight	4.5	22.8	27.8	-5.3	5.3	5.2	-5.1	4.9	2.0
Delta time in closed arm before/after self-admin	2.6	2.4	2.9	1.7	-1.7	-1.7	1.6	-1.7	-0.7
Delta time in open arm before/after self-admin	5.1	6.0	6.5	-2.4	2.5	2.4	-2.4	2.5	2.4
Diff in mean of infusions in LGA sessions	0.3	0.6	0.7	-0.8	0.8	0.8	-0.8	0.8	0.6
Delay discount exponential model param	1.3	1.8	2.6	-1.3	1.3	1.4	-1.4	1.6	0.9
Extinction: sum of active levers before priming	1.2	1.8	4.5	-1.1	1.1	1.1	-1.1	1.1	2.1
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.6	0.6	0.7	-0.7	0.6	0.3
Bone: final force	0.4	0.7	1.4	0.7	-0.7	-0.7	0.8	-0.8	-1.2
Bone: final moment	0.5	0.9	1.8	0.8	-0.8	-0.8	0.8	-0.9	-1.4
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.4	-0.4	-0.3	0.3	-0.6	-0.6
Glucose	1.2	1.9	2.4	1.6	-1.5	-1.6	1.5	-1.4	-0.3
Heart weight	1.5	2.4	3.0	-1.7	1.6	1.7	-1.7	1.4	1.0
Delay discount hyperbolic model param	1.8	2.4	3.3	-1.5	1.5	1.5	-1.6	1.8	1.2
Intermittent access intake day 1-15 change	0.1	0.4	2.2	-0.2	0.2	0.1	-0.2	0.3	1.5
Intermittent access intake escalation	0.1	0.5	2.3	-0.3	0.3	0.3	-0.3	0.5	1.5
Intermittent access intake escalation 2	0.2	0.4	1.5	0.4	-0.4	-0.5	0.4	-0.2	1.2
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	0.4	-0.4	-0.4	0.4	-0.5	0.6
Intermitt. access day 15 inactive lever presses	0.1	0.5	0.7	0.8	-0.8	-0.8	0.8	-0.8	-0.2
Intermitt. access escalation Index	0.2	0.7	1.1	-1.0	1.0	1.0	-0.9	0.7	0.0
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.3	0.3	0.3	-0.3	0.1	0.3
Intermittent access day 15 total infusions	0.6	1.4	3.7	-1.0	1.0	0.9	-0.9	0.9	1.9
Intermittent access terminal intake (last 3 days)	0.7	1.2	2.3	-1.0	1.0	1.0	-1.0	0.9	1.5
Intermittent access total infusions	0.4	0.5	1.6	-0.5	0.5	0.4	-0.4	0.5	1.3
Intermittent access day 1 locomotion	0.1	0.2	1.1	-0.0	0.1	0.0	0.0	0.0	1.1
Intermittent access day 15 total locomotion	0.2	0.7	2.5	-0.6	0.7	0.6	-0.6	0.7	1.6
Intermittent access total locomotion	0.7	0.8	2.4	-0.7	0.7	0.7	-0.7	0.8	1.6
Intermittent access standard deviation	0.0	0.0	0.2	0.1	-0.0	-0.1	0.1	-0.0	0.4
Left kidney weight	0.0	0.2	0.3	-0.5	0.5	0.5	-0.5	0.2	-0.4
Right kidney weight	0.1	0.5	0.8	-0.8	0.9	0.8	-0.8	0.5	-0.2
Cocaine induced anxiety	0.1	0.3	0.6	0.4	-0.5	-0.4	0.5	-0.7	-0.8
Post-drug Anxiety	0.2	0.3	0.4	-0.5	0.5	0.5	-0.5	0.6	0.6
Baseline Anxiety	0.5	0.8	1.8	-0.7	0.7	0.7	-0.8	1.1	1.3
Tail length	0.3	1.5	1.9	-1.4	1.3	1.4	-1.4	1.3	0.3
Length with tail	0.4	2.0	2.5	-1.6	1.5	1.6	-1.5	1.3	-0.6
Length without tail	0.1	0.8	1.0	-1.0	1.0	1.0	-0.9	0.7	-0.7
Times rat made contact with spout	0.0	0.0	0.1	0.1	-0.2	-0.1	0.0	-0.2	0.4
Lifetime Intake	0.3	0.4	0.5	-0.6	0.7	0.6	-0.5	0.7	0.5
Liver weight, left	4.3	7.4	8.3	-2.9	2.9	2.8	-2.8	2.8	2.1
Liver weight, right	3.6	6.3	7.0	-2.6	2.6	2.6	-2.6	2.5	1.9
Locomotor activity	0.0	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.4	0.2
Locomotor testing distance	0.0	0.1	0.1	0.4	-0.3	-0.4	0.4	-0.4	0.0
Locomotor testing rearing	0.1	0.2	1.0	0.2	-0.2	-0.2	0.2	-0.1	1.0
Locomotion in novel chamber	2.3	3.0	3.8	1.9	-1.8	-1.9	1.9	-1.9	-0.7
Locomotion in novel chamber post-restriction	0.1	0.4	2.2	-0.0	0.2	0.0	-0.0	0.6	1.5
Fecal boli incidents, locomotor time 1	0.9	2.4	2.7	-1.5	1.6	1.5	-1.6	1.6	1.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.5	-0.5	-0.5	0.6	-0.5	-0.8
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	0.1	0.3
Bouts of movement, locomotor time 1	0.5	0.6	1.1	0.7	-0.7	-0.7	0.7	-0.6	-1.0
Total resting periods, locomotor time 1	0.1	0.2	0.5	0.3	-0.3	-0.3	0.3	-0.3	-0.7
Rest time, locomotor task time 1	0.3	0.4	0.8	-0.5	0.5	0.6	-0.6	0.7	0.9
Distance moved, locomotor task time 1	0.3	0.8	1.6	0.7	-0.7	-0.8	0.8	-1.0	-1.3
Vertical activity count, locomotor time 1	0.0	0.3	0.4	0.5	-0.4	-0.5	0.6	-0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.0	-1.0	1.0	0.9	-0.9	0.6	0.8
Bouts of movement, locomotor time 2	0.2	0.5	0.8	0.6	-0.7	-0.6	0.6	-0.7	-0.9
Total resting periods, locomotor time 2	0.0	0.1	0.5	0.3	-0.3	-0.2	0.2	-0.3	-0.7
Rest time, locomotor task time 2	0.2	0.4	1.8	-0.2	0.2	0.2	-0.3	0.6	1.3
Distance moved, locomotor task time 2	0.5	0.6	0.9	0.7	-0.7	-0.8	0.9	-1.0	-0.7
Vertical activity count, locomotor time 2	0.5	1.1	1.7	0.9	-0.8	-1.0	1.1	-1.3	-1.2
Light reinforcement 1	0.0	0.0	0.0	0.2	-0.1	-0.2	0.2	-0.2	0.0
Light reinforcement 2	0.2	0.5	0.7	0.8	-0.8	-0.8	0.8	-0.8	-0.1
Bone: marrow area	0.1	0.1	0.6	0.1	-0.2	-0.2	0.2	-0.4	-0.8
Bone: maximum diameter	0.5	1.0	2.3	0.8	-0.8	-0.9	0.9	-0.9	-1.5
Bone: maximum force	0.6	1.1	1.5	1.0	-1.0	-1.0	1.0	-1.0	-1.2
Bone: maximum moment	0.7	1.4	1.9	1.1	-1.1	-1.1	1.1	-1.2	-1.4
Mean time between licks in bursts	0.1	0.8	0.9	-0.9	0.9	0.9	-0.9	0.9	0.7
Mean num. licks in bursts	0.1	0.4	0.5	-0.7	0.6	0.7	-0.7	0.6	0.3
Cd content in liver	0.8	0.9	1.2	1.0	-1.0	-1.0	1.0	-1.1	-0.7
Co content in liver	0.3	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.6	0.4
Cu content in liver	1.3	1.6	1.9	1.3	-1.4	-1.3	1.3	-1.2	-0.9
Fe content in liver	2.1	2.6	3.1	-1.6	1.6	1.6	-1.6	1.5	1.8
K content in liver	0.2	0.2	0.5	-0.3	0.3	0.3	-0.3	0.3	0.7
Mg content in liver	0.5	0.5	0.6	0.8	-0.8	-0.8	0.7	-0.8	-0.1
Mn content in liver	0.2	0.2	0.2	0.5	-0.5	-0.4	0.4	-0.4	0.2
Na content in liver	0.0	0.1	0.3	-0.1	0.2	0.0	0.0	0.2	0.5
Rb content in liver	0.1	0.1	0.3	-0.3	0.3	0.2	-0.2	0.2	0.6
Se content in liver	0.5	0.6	0.7	0.8	-0.8	-0.8	0.8	-0.8	-0.4
Sr content in liver	0.4	0.4	0.4	-0.7	0.7	0.7	-0.7	0.6	0.1
Zn content in liver	0.3	0.3	0.4	-0.7	0.6	0.7	-0.7	0.6	-0.1
Bone: minimum diameter	0.1	0.2	0.5	0.4	-0.3	-0.4	0.4	-0.4	-0.7
Time in familiar zone, hab. session 1	0.4	0.4	0.6	0.6	-0.6	-0.6	0.6	-0.5	-0.8
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.4	0.4	0.4	-0.5	0.4	0.7
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.4	-0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.3	-0.3	-0.3	0.3	-0.5	-0.5
Locomotion velocity, hab. session 1	0.4	0.5	0.8	0.7	-0.7	-0.7	0.7	-0.9	-0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	-0.4	-0.3	0.3	-0.3	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	-0.4	-0.4	0.5	-0.5	-0.6
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.6	0.6	0.6	-0.6	0.5	0.4
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.4	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.3	-0.3	-0.3	0.3	-0.4	0.1
Novel to familiar place preference ratio	0.6	0.7	0.9	-0.9	0.9	0.9	-0.9	0.8	0.3
Novelty place preference	0.8	1.0	1.2	-1.1	1.1	1.1	-1.1	1.0	0.4
Time in novel zone, NPP test	0.9	1.0	1.3	-1.1	1.1	1.1	-1.1	1.0	0.5
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.0	0.1
Total locomotion distance, NPP test	0.8	1.1	1.6	1.1	-1.1	-1.1	1.0	-1.3	-0.5
Locomotion velocity, NPP test	0.9	1.3	1.9	1.2	-1.2	-1.2	1.2	-1.4	-0.7
Intraocular pressure	0.9	1.5	1.7	1.3	-1.3	-1.3	1.2	-1.2	-0.9
Delta distance traveled before/after self-admin	4.0	4.4	10.3	-1.8	1.8	1.8	-1.8	1.6	3.2
Delta ambulatory time before/after self-admin	2.9	5.1	17.7	-1.6	1.6	1.6	-1.6	1.4	4.2
Parametrial fat weight	5.7	13.4	15.4	-3.9	3.9	3.9	-3.9	3.8	2.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.1	0.2	-0.2	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.1	0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.5	0.3
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.2	0.3
Pavlov. Cond. latency score	0.0	0.0	0.2	0.1	-0.0	-0.1	0.1	-0.0	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.1	-0.1	-0.1	0.2	-0.1	0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.4	0.4	0.5	-0.5	0.4	-0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.5	-0.5	-0.5	0.5	-0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	0.3
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.1	-0.1	0.2	-0.1	0.3
Pavlov. Cond. lever latency	2.5	3.5	3.7	-1.9	1.9	1.9	-1.9	1.9	1.8
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	-0.6	-0.5	0.5	-0.5	-0.2
Pavlov. Cond. change in total contacts	0.9	2.2	2.4	1.5	-1.5	-1.5	1.5	-1.5	-1.4
Pavlov. Cond. index score	1.8	2.9	3.2	1.8	-1.8	-1.8	1.7	-1.8	-1.2
Pavlov. Cond. latency score	2.1	3.3	3.8	1.9	-1.9	-1.9	1.9	-1.9	-1.3
Pavlov. Cond. lever contacts	1.3	1.9	2.0	1.4	-1.4	-1.4	1.3	-1.4	-1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.6	0.7	-0.8	0.9	0.8	-0.8	0.8	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.1	2.5	1.5	-1.6	-1.6	1.5	-1.5	-1.0
Pavlov. Cond. response bias	1.2	1.7	1.8	1.3	-1.3	-1.3	1.3	-1.3	-1.3
Time in closed arm before self-admin	0.8	1.4	2.2	-1.2	1.3	1.2	-1.1	1.5	-0.2
Time in closed arm after self-admin	1.5	1.7	4.5	1.1	-1.0	-1.1	1.2	-0.9	-2.1
Time in open arm before self-admin	1.2	1.4	2.1	1.3	-1.4	-1.2	1.2	-1.4	-0.4
Time in open arm after self-admin	1.3	1.4	2.3	-1.1	1.1	1.1	-1.1	1.1	1.5
Bone: periosteal estimation	0.5	1.2	2.6	0.9	-0.9	-0.9	1.0	-1.1	-1.6
Bone: periosteal perimeter	0.5	0.9	2.3	0.8	-0.7	-0.8	0.8	-0.9	-1.5
Bone: post-yield work	0.2	0.4	1.0	-0.5	0.6	0.5	-0.5	0.6	1.0
Progressive ratio test 1 active lever presses	0.3	0.6	0.8	0.8	-0.8	-0.9	0.9	-0.7	-0.4
Progressive ratio test 1 breakpoint	0.4	0.7	0.9	0.9	-0.8	-0.9	1.0	-0.7	-0.5
Progressive ratio test 1 inactive lever presses	1.0	2.7	3.0	1.6	-1.6	-1.7	1.7	-1.7	-1.6
Progressive ratio test 2 active lever presses	0.2	0.3	0.4	0.6	-0.6	-0.7	0.6	-0.5	-0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.5	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.4	-0.5
Incentive Sensitization - Responses	0.0	0.0	0.2	-0.1	0.1	0.1	-0.2	0.0	0.4
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	-0.2	0.1	0.2	-0.3	0.1	0.6
Sum of active levers in priming session hrs 5-6	2.2	2.1	3.9	-1.3	1.3	1.3	-1.3	1.3	2.0
Progressive ratio	0.0	0.1	0.2	-0.3	0.3	0.4	-0.4	0.2	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.3	0.4	-0.3	0.5	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.4	-0.4	-0.5	0.5	-0.2	-0.3
Retroperitoneal fat weight	0.4	1.7	2.2	-1.4	1.5	1.4	-1.4	1.4	-0.4
Reaction time number correct	0.3	1.1	1.3	-1.2	1.1	1.2	-1.1	1.0	-0.3
Reaction time mean minus median	0.1	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	0.7
Reaction time mean minus median AUC	0.3	2.3	2.9	-1.5	1.5	1.5	-1.5	1.7	1.3
Reaction time num false alarms	4.3	7.3	8.4	2.8	-2.8	-2.8	2.8	-2.9	-1.9
Reaction time num false alarms AUC	3.3	7.5	8.6	2.8	-2.8	-2.8	2.8	-2.9	-2.1
Reaction time trials correct on left	0.3	1.1	1.3	-1.2	1.1	1.2	-1.1	1.0	-0.3
Reaction time trials on left	0.3	1.1	1.4	-1.2	1.1	1.2	-1.1	1.1	-0.3
Reaction time mean	0.5	1.0	1.3	-1.1	1.0	1.1	-1.1	1.1	0.6
Reaction time mean AUC	0.3	0.8	1.0	-0.9	0.9	0.9	-0.9	1.0	0.6
Median of all reaction times	0.4	0.7	0.8	-0.9	0.9	0.9	-0.9	0.9	0.4
Reaction time omissions	1.0	1.7	1.8	-1.3	1.3	1.3	-1.3	1.3	1.2
Reaction time false alarm rate	5.3	7.4	8.8	2.9	-2.9	-2.9	2.9	-3.0	-1.5
Reaction time premature initiation rate	0.1	0.2	0.3	-0.4	0.5	0.4	-0.4	0.5	0.1
Reaction time premature initiations	0.2	0.5	0.6	-0.7	0.8	0.7	-0.7	0.8	-0.1
Std. dev. reaction times	0.4	1.3	1.5	-1.1	1.1	1.1	-1.1	1.2	1.2
Reaction time trials completed	0.3	1.1	1.4	-1.2	1.1	1.2	-1.1	1.1	-0.3
Reaction time trials AUC	0.3	0.9	1.1	-1.1	1.0	1.1	-1.0	1.0	-0.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.3	0.2	0.3	-0.2	-0.1	-0.6
Run reversals in cocaine runway, males	0.4	0.4	2.1	-0.2	0.3	0.2	-0.1	0.2	1.5
Latency to leave start box in cocaine runway	0.1	0.2	0.3	0.4	-0.5	-0.3	0.2	-0.6	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.8	-0.0	-0.1	0.0	-0.1	-0.1	0.9
Latency to leave start box in cocaine runway, M	0.7	0.7	3.6	0.3	-0.4	-0.2	0.2	-0.4	-1.9
Std. dev. time between licks in bursts	0.0	0.0	0.2	-0.1	0.0	0.1	-0.1	0.0	0.5
Total sessions with >9 infusions	0.2	0.2	0.5	-0.4	0.5	0.4	-0.3	0.4	-0.7
Short access day 1 total inactive lever presses	1.7	3.3	3.9	-2.0	2.0	1.9	-1.8	2.0	1.3
Short access day 10 total inactive lever presses	0.0	0.0	0.2	0.1	-0.1	-0.2	0.2	0.0	0.4
Short access day 1 total infusions	0.2	0.4	0.6	-0.6	0.7	0.6	-0.5	0.8	-0.4
Short access day 10 total infusions	0.1	0.1	0.2	-0.4	0.5	0.4	-0.3	0.4	-0.1
Short access total infusions	0.0	0.1	0.2	-0.2	0.2	0.1	-0.0	0.3	-0.5
Short access day 1 locomotion	0.0	0.1	0.2	0.2	-0.2	-0.2	0.3	-0.2	-0.4
Short access day 10 total locomotion	0.2	0.7	0.9	0.9	-0.8	-0.9	0.9	-1.0	0.1
Short access total locomotion	0.4	0.6	0.9	0.8	-0.8	-0.9	0.9	-0.9	0.1
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	-0.3	-0.4	0.4	-0.1	0.4
Compulsive drug intake	0.7	1.0	1.6	-1.0	1.1	1.0	-1.0	1.3	0.3
One hour access (shock baseline)	0.1	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.5	0.5
Social response proportion	1.6	2.0	2.5	-1.6	1.5	1.5	-1.5	1.4	0.9
Social responses	1.5	2.0	2.5	-1.6	1.6	1.5	-1.5	1.4	0.6
Social time	1.2	1.9	2.3	-1.3	1.3	1.3	-1.2	1.5	1.5
Soleus weight	2.1	6.2	6.9	-2.6	2.6	2.6	-2.6	2.6	1.9
Bone: stiffness	1.4	2.6	3.0	-1.7	1.7	1.7	-1.7	1.6	1.1
Tibialis anterior weight	2.5	8.8	9.7	-3.1	3.1	3.1	-3.1	3.1	2.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.8	-0.1	0.2	0.1	-0.1	0.1	-1.4
Time to tail flick, vehicle, after self-admin	0.3	0.5	0.6	0.7	-0.7	-0.8	0.8	-0.6	-0.8
Time to tail flick, test, before self-admin	0.1	0.1	0.6	-0.1	0.1	0.1	-0.1	0.2	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.5	-0.3	0.2	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.2	0.5	-0.5	-0.5	0.4	-0.5	1.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.6	-0.7	-0.6	0.6	-0.6	0.2
Tibia length	0.0	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	-0.1
Ambulatory time before self-admin	1.6	4.9	16.4	1.6	-1.5	-1.6	1.7	-1.5	-4.0
Ambulatory time after self-admin	0.0	0.0	0.2	0.0	0.0	-0.0	0.0	-0.0	0.4
Bone: tissue strength	1.6	1.7	1.9	1.3	-1.3	-1.3	1.4	-1.3	-1.2
Total heroin consumption	4.5	5.3	7.7	-2.2	2.1	2.3	-2.4	2.0	2.8
Bone: trabecular number	2.6	4.8	5.3	-2.3	2.3	2.3	-2.3	2.3	1.7
Bone: trabecular spacing	0.2	0.3	0.4	0.6	-0.6	-0.6	0.7	-0.6	-0.2
Bone: trabecular thickness	0.0	0.1	0.3	0.1	-0.1	-0.0	0.1	-0.2	-0.6
Bone: trabecular tissue density	1.1	1.9	2.0	1.4	-1.4	-1.4	1.4	-1.3	-1.3
Water consumed over 24 hours	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1	-0.4	-0.2
Number of responses in last shaping day	1.0	1.3	2.0	1.2	-1.1	-1.1	1.2	-0.7	-1.4