Hub : Genes

Fkbp2l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_213598266_213599054	0.1	0.06	2.0e-03	0.02	0.01	0.02	0.01	2.2e-02	5.0e-02	2.6e-02	1.2e-01
2	PL	gene expression	Fkbp2l1	0.04	0.03	2.4e-03	0.03	0.03	0.02	0.02	5.5e-04	7.6e-04	1.4e-03	1.2e-03
3	PL	intron excision ratio	chr1_213598302_213598436	0.05	0.04	1.6e-03	0.02	0.01	0.02	0.02	1.8e-03	1.3e-02	4.4e-03	6.4e-03
4	Liver	intron excision ratio	chr1_213597525_213597643	0.04	0.03	5.5e-03	-0	0	0	0	4.5e-01	1.9e-01	7.9e-02	1.6e-01
5	Brain	gene expression	Fkbp2l1	0.05	0.04	6.6e-03	0.01	0.01	0.02	0.02	2.7e-02	1.7e-02	3.0e-03	8.9e-03
6	LHb	intron excision ratio	chr1_213597525_213597643	0.3	0.16	7.0e-03	0.11	0.1	0.1	0.1	1.7e-03	3.0e-03	1.9e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.6	1.2	2.7	0.9	-1.0	-0.8	0.3	-1.6	-1.4
Area under the delay curve	0.2	0.4	0.7	-0.1	-0.4	-0.7	0.4	-0.8	-0.9
BMI with tail	2.3	8.0	17.1	2.4	-1.7	-1.9	1.5	-4.1	-4.1
BMI without tail	0.3	1.5	3.5	1.5	-0.2	-0.3	-0.1	-1.9	-1.8
Body weight	1.1	5.0	13.8	3.7	-0.0	-0.1	-0.4	-2.7	-2.9
Weight adjusted by age	0.3	1.0	2.3	1.5	1.3	1.1	-0.8	0.4	-0.4
Bone surface	1.4	2.7	9.7	3.1	-0.4	-0.1	-0.4	-1.9	-1.6
Bone volume	0.9	1.8	3.9	1.8	-1.0	-0.8	0.4	-2.0	-1.4
Breakpoint value in progressive ratio session	0.8	1.4	4.1	2.0	1.1	1.3	-1.1	0.3	-0.2
Number of licking bursts	0.1	0.2	0.4	0.6	0.3	0.4	-0.6	0.5	-0.1
Context. condit. distance diff. score	0.9	1.1	2.7	-1.6	-0.9	-1.1	1.3	-0.3	-0.5
Locomotion velocity, session 1	0.1	0.1	0.6	0.2	-0.2	-0.3	-0.0	-0.3	-0.8
Locomotion distance, session 1	1.0	1.2	3.3	0.8	-0.8	-0.8	0.5	-1.5	-1.8
Locomotion velocity, session 2	0.8	1.0	3.5	1.9	0.5	0.4	-0.2	-0.5	-1.4
Locomotion distance, session 2	0.3	0.4	1.1	1.0	-0.1	-0.1	-0.3	-0.7	-1.1
Locomotion velocity, session 3	3.7	4.2	6.4	-0.5	-2.1	-2.2	1.9	-2.5	-2.5
Locomotion distance, session 3	0.4	0.4	0.9	-0.2	-0.4	-0.5	0.7	-0.8	-1.0
Stereotopy head waving bouts, day 3	2.9	3.4	6.2	-0.8	-2.1	-2.0	1.5	-2.5	-1.7
Stereotopy head waving duration, day 3	1.1	1.3	2.0	-0.8	-1.4	-1.4	1.1	-1.4	-0.6
Locomotion velocity, session 7	2.2	2.4	4.4	-0.7	-1.7	-1.6	1.5	-2.1	-1.4
Locomotion distance, session 7	0.5	0.7	2.1	-0.2	-0.7	-0.6	0.4	-1.5	-0.9
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	-0.1	-0.9	-0.9	0.8	-0.4	-0.5
Stereotopy head waving duration, day 7	0.2	0.3	1.0	1.0	-0.1	-0.1	0.2	0.1	-0.7
Locomotion velocity, session 8	0.4	0.5	1.1	1.1	0.5	0.6	-0.9	0.4	-0.4
Locomotion distance, session 8	1.3	1.9	2.7	-0.5	-1.6	-1.6	1.2	-1.4	-1.4
Degree of sensitization distance	0.7	0.7	1.6	-0.0	-0.9	-0.9	0.5	-1.3	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.5	0.7	-0.3	-0.3	0.3	0.1	-0.5
Conditioned locomotion	0.9	1.1	3.5	1.4	0.6	0.6	-1.9	0.3	-0.5
Cocaine response after cond. corrected	0.6	0.9	1.9	-1.4	-0.9	-1.1	0.8	-0.8	-0.4
Cocaine response after cond. not corrected	0.6	0.8	1.4	-1.2	-0.9	-1.0	0.8	-1.0	-0.4
Cocaine response before conditioning	0.3	0.4	0.9	0.9	0.7	0.8	-0.5	-0.1	0.2
Saline control response	1.9	2.6	6.1	2.5	1.8	2.0	-1.4	0.2	-0.6
Bone: connectivity density	0.9	1.4	4.1	2.0	-0.3	-0.0	-0.2	-1.4	-1.5
Bone: cortical apparent density	0.8	1.2	2.0	0.3	1.3	1.4	-0.9	1.4	0.8
Bone: cortical area	0.3	0.5	1.5	1.1	0.1	0.2	0.3	-0.1	-1.2
Bone: cortical porosity	0.2	0.2	0.4	0.5	0.4	0.5	-0.6	0.2	0.3
Bone: cortical porosity	0.3	0.4	0.8	0.9	0.6	0.6	-0.8	0.1	-0.0
Bone: cortical thickness	2.7	4.5	7.8	2.3	2.6	2.8	-2.1	1.8	-0.1
Bone: cortical thickness	0.6	0.7	1.3	0.7	1.0	1.1	-1.1	0.4	0.1
Bone: cortical tissue density	0.9	1.5	2.3	0.5	1.4	1.5	-1.1	1.5	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	0.5	0.3	-0.0	0.3	0.0
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.2	0.2	0.9	0.7	-0.5	1.1	0.9
Condit. Reinf. active responses	0.1	0.2	0.4	0.1	-0.2	-0.4	0.6	-0.3	-0.6
Condit. Reinf. inactive responses	1.2	1.5	2.3	-0.4	-1.3	-1.3	1.2	-1.5	-1.4
Incentive salience index mean	0.2	0.2	0.6	0.6	0.1	-0.0	0.4	-0.4	-0.8
Condit. Reinf. lever presses	0.4	0.6	1.4	0.7	-0.5	-0.4	0.5	-1.0	-1.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.3	-0.8	-0.7	0.0	-0.5	0.2
Condit. Reinf. active-inactive response ratio	1.4	2.2	4.4	-0.9	-2.0	-2.1	1.2	-1.6	0.0
Condit. Reinf. active responses	0.0	0.1	0.2	0.3	-0.1	0.1	-0.4	0.2	-0.0
Condit. Reinf. inactive responses	0.9	1.3	2.6	0.8	1.2	1.6	-1.2	1.2	-0.1
Condit. Reinf. lever presses	0.5	0.7	2.6	1.6	-0.2	0.3	-0.3	-0.6	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	0.6	0.2	0.4	-0.6	0.3	0.0
Conditioned reinforcement - actives	0.0	0.2	0.6	0.1	-0.8	-0.4	0.5	-0.3	0.2
Conditioned reinforcement - inactives	1.1	3.1	9.2	-2.0	-1.7	-1.5	3.0	0.2	-0.6
Conditioned locomotion	2.7	4.1	11.0	-3.3	-2.1	-2.0	2.3	0.3	0.1
Patch foraging indifference point 0 sec	0.0	0.1	0.4	-0.0	0.1	0.1	0.7	-0.2	0.0
Patch foraging indifference point AUC	0.6	1.3	3.1	1.8	1.4	1.3	-0.9	0.6	-0.0
Delay disc. indifference point, 0s delay	1.1	1.2	1.8	-0.4	-1.3	-1.2	0.8	-1.3	-1.3
Delay disc. indifference point, 16s delay	0.5	0.7	1.8	-0.9	-0.7	-0.8	1.3	0.0	-0.7
Delay disc. indifference point, 2s delay	0.8	0.9	1.6	-0.3	-1.1	-1.3	0.8	-0.9	-0.9
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	-0.2	0.7	0.4	0.1	0.4	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	-0.2	-0.1	-0.4	0.3	-0.8	-0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.0	-0.2	-0.3	-0.3	-0.5	-0.2
Indifference point function ln k	1.5	4.4	12.4	-3.5	-2.2	-1.9	2.2	-1.0	0.2
Indifference point function log k	1.5	4.4	12.4	-3.5	-2.2	-1.9	2.2	-1.0	0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.1	0.6	0.6	0.4	0.2	0.2
Patch foraging total patch changes 12 sec	1.9	2.5	6.4	2.5	1.7	1.9	-0.8	0.3	-1.1
Patch foraging total patch changes 18 sec	0.2	0.4	0.8	0.9	0.8	0.8	-0.0	-0.1	0.5
Patch foraging total patch changes 24 sec	0.6	1.9	3.3	1.8	1.7	1.5	0.2	0.8	-1.4
Patch foraging total patch changes 6 sec	0.3	0.6	1.7	1.3	0.7	0.7	0.1	-0.1	-0.8
Patch foraging time to switch 0 sec	0.5	1.7	3.3	1.6	-0.8	-0.9	-0.3	-1.8	-1.7
Patch foraging water rate 0 sec	0.7	2.5	7.9	-2.8	-0.0	0.2	1.7	1.7	1.3
Patch foraging water rate 12 sec	1.0	4.1	14.2	-3.8	-0.4	-0.6	2.2	1.9	1.4
Patch foraging water rate 18 sec	0.6	1.4	4.2	-2.1	-0.7	-0.5	1.8	-0.0	-0.0
Patch foraging water rate 24 sec	1.2	1.7	6.7	-2.6	-0.4	-0.6	1.4	0.4	1.0
Patch foraging water rate 6 sec	1.5	2.2	8.3	-2.9	-0.1	-0.3	1.9	0.8	0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	-0.5	-0.1	-0.3	0.8	0.0	-0.7
Distance traveled before self-admin	0.2	0.5	1.9	1.0	-0.3	-0.3	0.4	-0.1	-1.4
Distance traveled after self-admin	0.4	0.8	2.0	0.6	1.0	0.9	-0.6	1.4	0.3
Extensor digitorum longus weight	2.5	10.1	34.8	5.9	2.6	2.5	-2.4	-0.8	-2.7
Bone: elastic displacement	0.6	0.7	1.4	-1.0	0.8	0.6	-0.6	1.2	0.8
Bone: elastic work	0.9	1.2	2.0	1.1	1.4	1.4	-1.1	0.4	-0.9
Bone: endosteal estimation	3.1	7.5	12.6	-1.2	-3.2	-3.3	2.6	-3.6	-1.8
Bone: endosteal perimeter	3.7	9.0	14.0	-1.4	-3.7	-3.7	3.1	-3.4	-1.7
Epididymis fat weight	1.9	9.4	15.9	-3.5	-3.5	-3.6	4.0	-1.7	-0.8
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	0.4	0.4	0.5	-0.3	-0.9	-0.9
Delta time in open arm before/after self-admin	0.2	0.3	1.0	0.5	0.4	0.4	0.4	1.0	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.4	0.9	0.8	0.7	0.9	-0.4	0.1	-0.6
Delay discount exponential model param	0.2	0.2	0.5	-0.0	0.2	0.5	-0.2	0.7	0.7
Extinction: sum of active levers before priming	0.6	0.9	3.1	1.8	0.6	0.4	-0.5	-0.4	-1.0
Active lever presses in extinction session 6	1.0	1.0	4.0	2.0	0.6	0.7	-0.7	0.1	-0.8
Bone: final force	1.0	1.6	4.8	2.2	0.1	0.2	0.1	-1.1	-1.9
Bone: final moment	1.0	1.6	4.5	2.1	0.1	0.2	0.2	-1.0	-2.0
Food consumed during 24 hour testing period	0.2	0.5	1.5	0.2	0.6	0.6	0.1	1.2	0.9
Glucose	3.6	5.7	9.0	-2.1	-2.6	-2.7	3.0	-2.2	-1.4
Heart weight	2.4	3.8	6.5	-1.2	-2.0	-2.3	1.8	-2.5	-1.7
Delay discount hyperbolic model param	0.3	0.3	0.7	-0.0	0.4	0.7	-0.3	0.8	0.8
Intermittent access intake day 1-15 change	0.1	0.7	1.9	-1.4	-0.7	-0.2	0.8	0.4	1.0
Intermittent access intake escalation	0.1	0.6	1.5	-1.2	-0.7	-0.2	0.7	0.4	1.1
Intermittent access intake escalation 2	0.4	0.6	1.3	-1.1	-0.7	-0.4	1.1	0.4	0.5
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.0	-0.4	-0.1	0.0	0.3	0.7	1.0
Intermitt. access day 15 inactive lever presses	0.8	4.3	11.4	-1.6	-2.3	-2.2	3.4	-0.4	-1.3
Intermitt. access escalation Index	0.3	1.0	4.1	-2.0	-0.7	-0.5	0.9	0.4	0.3
Intermittent access day 1 total infusions	3.1	9.3	16.2	-1.9	-4.0	-3.6	3.0	-2.8	-2.4
Intermittent access day 15 total infusions	2.9	7.1	14.0	-2.8	-3.7	-3.1	2.9	-1.6	-0.7
Intermittent access terminal intake (last 3 days)	5.4	9.4	17.2	-2.5	-4.1	-3.5	3.5	-2.2	-1.8
Intermittent access total infusions	7.4	8.7	15.9	-2.2	-4.0	-3.4	3.1	-2.6	-1.9
Intermittent access day 1 locomotion	2.9	5.3	8.9	-1.7	-3.0	-2.7	2.4	-2.0	-1.9
Intermittent access day 15 total locomotion	1.7	6.7	11.6	-2.5	-3.4	-2.8	3.3	-1.6	-1.1
Intermittent access total locomotion	10.3	12.4	20.1	-2.9	-4.5	-4.1	4.3	-2.4	-2.2
Intermittent access standard deviation	0.2	1.1	2.1	-1.4	-1.2	-0.8	1.5	-0.0	0.0
Left kidney weight	0.4	3.2	5.6	-1.6	-2.2	-2.4	1.8	-1.6	-0.6
Right kidney weight	0.2	1.7	2.7	-1.2	-1.4	-1.6	1.5	-1.4	-0.4
Cocaine induced anxiety	0.0	0.1	0.3	0.2	-0.2	-0.4	-0.2	-0.1	0.5
Post-drug Anxiety	0.2	0.2	0.8	0.9	-0.0	-0.0	-0.4	-0.3	-0.0
Baseline Anxiety	0.3	0.4	1.1	0.6	0.6	1.1	-0.4	0.2	-0.7
Tail length	0.6	3.2	5.4	1.4	2.1	2.3	-2.0	1.5	1.0
Length with tail	0.9	4.1	9.6	3.1	2.1	2.2	-2.3	0.5	0.0
Length without tail	0.5	2.5	7.4	2.7	1.6	1.6	-1.4	0.0	-0.7
Times rat made contact with spout	1.1	1.3	2.1	0.8	1.2	1.4	-1.5	0.9	1.0
Lifetime Intake	5.3	6.6	12.6	-1.9	-3.5	-2.9	2.4	-2.5	-1.7
Liver weight, left	0.5	0.9	1.6	-1.3	-1.1	-1.1	0.8	-0.7	0.0
Liver weight, right	1.4	2.5	4.1	-2.0	-1.5	-1.6	1.9	-1.1	-1.2
Locomotor activity	0.7	1.0	4.1	-2.0	-0.2	0.2	0.5	0.2	1.3
Locomotor testing distance	0.5	1.1	4.9	-2.2	-0.2	-0.0	1.1	0.2	0.9
Locomotor testing rearing	0.2	0.9	3.8	-2.0	-0.3	-0.6	1.0	0.0	0.4
Locomotion in novel chamber	3.1	4.1	7.0	-2.6	-2.4	-2.2	2.5	-0.7	-0.3
Locomotion in novel chamber post-restriction	0.7	2.2	4.7	-2.2	-1.9	-1.6	1.2	-0.5	1.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.2	-0.5	-0.5	0.5	-0.3	0.2
Change in fecal boli incidents, locomotor task	0.1	0.2	0.5	-0.1	-0.2	-0.3	-0.4	-0.7	-0.4
Time >=10cm from walls, locomotor time 1	2.8	3.5	7.0	-0.7	-2.4	-2.6	1.7	-2.0	-0.8
Bouts of movement, locomotor time 1	4.8	6.2	9.7	1.4	3.0	3.1	-2.3	2.4	2.4
Total resting periods, locomotor time 1	3.9	4.5	7.3	1.1	2.5	2.7	-1.8	2.2	2.2
Rest time, locomotor task time 1	0.5	0.8	2.2	-1.4	-0.2	-0.5	0.2	0.5	1.5
Distance moved, locomotor task time 1	0.2	0.7	2.3	0.3	-0.7	-0.6	0.7	-0.7	-1.5
Vertical activity count, locomotor time 1	0.2	1.1	2.0	-1.2	-1.4	-1.2	1.0	-0.7	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.4	0.1	-0.1	-0.2	0.7	0.6
Bouts of movement, locomotor time 2	0.2	0.6	1.3	0.7	1.2	1.0	-0.2	0.7	0.1
Total resting periods, locomotor time 2	0.1	0.2	0.5	0.4	0.7	0.5	-0.1	0.5	0.3
Rest time, locomotor task time 2	1.0	1.7	3.1	-1.7	-1.5	-1.6	1.0	-1.2	0.4
Distance moved, locomotor task time 2	1.0	1.4	1.8	1.3	1.3	1.3	-1.3	1.1	0.4
Vertical activity count, locomotor time 2	0.3	0.7	1.1	-0.1	0.8	1.0	-1.0	0.9	0.8
Light reinforcement 1	0.1	0.4	1.1	-0.2	0.5	0.7	-0.1	0.8	1.1
Light reinforcement 2	0.8	1.8	5.1	-0.9	-1.6	-1.3	2.3	-0.8	-0.4
Bone: marrow area	3.1	7.5	12.6	-1.3	-3.2	-3.3	2.5	-3.5	-1.8
Bone: maximum diameter	0.4	0.9	1.1	0.6	-1.0	-1.0	0.9	-1.0	-0.9
Bone: maximum force	1.9	3.8	8.7	2.5	-0.8	-0.7	0.7	-2.5	-2.9
Bone: maximum moment	1.9	3.7	9.2	2.4	-0.7	-0.6	0.8	-2.3	-3.0
Mean time between licks in bursts	0.1	0.8	1.5	0.5	1.2	1.2	-1.0	0.4	-0.6
Mean num. licks in bursts	0.1	0.2	0.8	-0.5	0.3	0.4	-0.2	0.3	0.9
Cd content in liver	0.8	0.9	1.6	-1.2	-0.8	-1.3	1.1	-0.0	0.5
Co content in liver	2.1	2.5	5.1	-1.2	1.4	1.1	-1.1	2.3	2.0
Cu content in liver	0.2	0.3	0.9	-0.1	0.4	0.1	-0.4	0.7	0.9
Fe content in liver	0.1	0.1	0.3	0.4	-0.4	-0.4	0.2	-0.6	-0.1
K content in liver	0.3	0.3	0.8	0.6	-0.1	-0.1	-0.4	-0.9	-0.6
Mg content in liver	0.3	0.3	0.5	-0.7	-0.4	-0.6	0.6	-0.4	-0.7
Mn content in liver	1.0	1.2	3.9	2.0	0.8	0.9	0.1	-0.0	-1.3
Na content in liver	0.2	0.2	0.6	0.8	0.5	0.5	-0.1	0.2	-0.4
Rb content in liver	0.8	1.0	2.9	-1.7	-0.9	-1.1	0.4	-0.5	0.5
Se content in liver	0.3	0.4	1.1	-0.4	-0.6	-0.7	1.1	0.1	0.3
Sr content in liver	1.8	1.5	3.0	1.7	1.4	1.5	-1.1	1.0	-0.0
Zn content in liver	0.5	0.5	1.2	0.7	1.1	0.6	-0.6	0.9	0.0
Bone: minimum diameter	2.9	5.7	7.5	-1.1	-2.7	-2.7	2.6	-2.5	-2.2
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.6	-0.6	-0.3	0.5	-0.8	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.4	0.2	-0.1	-0.0	0.6	0.0
Total zone transitions, hab. session 1	0.2	0.3	1.0	1.0	0.3	0.2	-0.6	0.3	-0.0
Total locomotion distance, hab. session 1	0.8	1.2	2.0	-0.6	-1.4	-1.4	1.0	-1.1	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.6	-0.1	-0.8	-0.8	0.4	-0.6	-0.4
Time in familiar zone, hab. session 2	0.4	0.5	1.0	-0.1	0.8	1.0	-1.0	0.3	0.4
Time in novel zone, hab. session 2	0.4	0.4	1.0	0.3	-0.4	-0.7	1.0	-0.1	-0.9
Total zone transitions, hab. session 2	0.9	1.2	3.2	1.4	-0.4	-0.3	-0.1	-1.3	-1.8
Total locomotion distance, hab. session 2	1.0	1.3	2.4	0.0	-1.2	-1.1	0.7	-1.6	-1.4
Locomotion velocity, hab. session 2	1.2	1.7	3.2	-0.2	-1.5	-1.3	0.9	-1.8	-1.3
Novel to familiar place preference ratio	0.2	0.3	1.4	1.2	0.1	0.1	-0.0	-0.6	-0.2
Novelty place preference	0.1	0.1	0.6	0.8	0.0	-0.1	0.3	-0.4	-0.1
Time in novel zone, NPP test	0.1	0.1	0.4	0.6	-0.0	-0.2	0.4	-0.5	-0.2
Total zone transitions, NPP test	0.6	0.9	3.9	2.0	0.1	0.2	-0.7	-0.6	-0.9
Total locomotion distance, NPP test	0.5	0.7	1.4	0.3	-1.0	-0.9	0.3	-1.2	-0.9
Locomotion velocity, NPP test	0.2	0.3	0.7	0.4	-0.7	-0.6	-0.0	-0.8	-0.4
Intraocular pressure	0.9	1.4	3.8	-1.3	0.7	0.3	0.4	1.5	2.0
Delta distance traveled before/after self-admin	0.9	0.9	1.4	-0.5	1.1	1.1	-0.7	1.2	1.1
Delta ambulatory time before/after self-admin	0.6	1.0	2.2	-0.2	1.0	0.8	-0.8	1.5	1.1
Parametrial fat weight	3.3	7.8	11.9	-3.0	-3.3	-3.5	3.3	-2.0	-0.6
Pavlov. Cond. lever latency	0.2	0.3	1.3	-0.5	0.0	-0.2	-0.3	0.4	1.1
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	0.6	-0.4	-0.2	0.4	-0.6	-1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.3	-0.4	-0.3	0.7	-0.2	-0.6
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	0.3	0.5	0.0	0.4	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.5	0.4	0.0	0.3	0.2	0.0	-0.7
Pavlov. Cond. lever contacts	0.3	0.3	1.3	0.2	-0.2	-0.0	0.4	-0.5	-1.2
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	-0.7	-0.5	-0.7	0.3	-0.8	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.6	-0.9	0.4	0.3	0.2	1.0	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.7	0.2	0.5	0.0	0.3	-0.7
Pavlov. Cond. response bias	0.1	0.1	0.3	0.5	0.3	0.5	-0.0	0.3	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.9	0.3	-0.1	-0.4	0.5	0.9
Pavlov. Cond. magazine entry latency	1.3	1.8	6.3	2.5	1.0	1.3	-1.0	-0.3	-0.9
Pavlov. Cond. change in total contacts	0.3	0.6	2.5	1.6	0.0	0.1	0.1	-0.1	-1.1
Pavlov. Cond. index score	0.6	1.0	3.8	2.0	0.3	0.5	-0.1	-0.7	-1.1
Pavlov. Cond. latency score	0.5	0.9	3.2	1.8	-0.0	0.2	0.1	-0.8	-1.1
Pavlov. Cond. lever contacts	0.2	0.3	0.9	0.9	-0.1	0.3	0.1	-0.5	-0.6
Pavlov. Cond. magazine entry number	2.2	2.8	10.4	-3.2	-1.3	-1.5	0.9	0.1	1.4
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.7	-1.3	-0.6	-0.6	-0.0	0.4	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.2	4.6	2.1	0.5	0.7	-0.2	-0.5	-1.2
Pavlov. Cond. response bias	0.7	0.9	3.3	1.8	0.3	0.7	-0.2	-0.5	-1.2
Time in closed arm before self-admin	0.4	0.6	1.2	-0.6	-1.1	-1.0	1.1	-0.1	-0.4
Time in closed arm after self-admin	0.3	0.3	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.3
Time in open arm before self-admin	0.4	0.5	1.3	-0.4	0.8	0.8	-1.1	0.1	0.4
Time in open arm after self-admin	0.6	0.7	1.3	0.3	1.1	1.1	-0.7	0.9	0.4
Bone: periosteal estimation	1.5	3.6	6.0	0.0	-2.1	-2.0	1.9	-2.5	-1.9
Bone: periosteal perimeter	0.9	1.8	2.8	0.4	-1.4	-1.4	1.3	-1.7	-1.5
Bone: post-yield work	4.5	7.7	14.6	0.8	-3.1	-2.9	2.1	-3.8	-3.0
Progressive ratio test 1 active lever presses	0.5	0.8	2.0	-0.6	-1.4	-1.2	0.4	-0.9	-0.5
Progressive ratio test 1 breakpoint	0.5	0.8	2.0	-0.5	-1.4	-1.1	0.4	-0.9	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.3	1.3	-0.3	-0.3	0.1	1.1	0.2	-0.8
Progressive ratio test 2 active lever presses	2.5	3.5	5.9	-1.8	-2.4	-2.0	2.4	-1.1	-0.9
Progressive ratio test 2 breakpoint	2.7	3.5	6.0	-1.8	-2.4	-2.0	2.4	-1.0	-1.0
Progressive ratio test 2 inactive lever presses	2.3	7.4	15.8	-3.3	-3.1	-2.7	4.0	-0.6	-0.7
Incentive Sensitization - Responses	0.8	2.2	6.0	-0.2	-1.3	-1.1	2.4	-1.2	-1.6
Incentive Sensitization - Breakpoint	1.1	2.4	6.8	-0.4	-1.4	-1.2	2.6	-1.2	-1.6
Sum of active levers in priming session hrs 5-6	1.3	1.2	1.9	1.1	1.4	1.3	-0.8	1.2	0.8
Progressive ratio	0.6	1.6	4.3	1.2	-0.9	-0.9	0.8	-1.4	-2.1
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	0.2	0.2	-0.1	0.1	-0.2
Seeking ratio, punishment vs. effort	0.4	1.0	2.1	-1.5	0.7	0.7	-0.3	1.0	1.3
Retroperitoneal fat weight	4.5	20.3	45.2	-6.7	-4.7	-4.9	5.0	-2.2	0.2
Reaction time number correct	0.1	0.5	1.1	0.6	0.8	1.0	-0.5	0.7	0.1
Reaction time mean minus median	0.3	1.8	5.8	2.4	0.7	0.8	-1.8	-0.8	-0.3
Reaction time mean minus median AUC	0.2	1.5	3.7	1.7	1.0	1.1	-1.9	-0.0	0.2
Reaction time num false alarms	0.2	0.3	0.6	-0.7	0.6	0.8	-0.3	0.1	0.7
Reaction time num false alarms AUC	0.3	0.6	1.5	-0.1	1.0	1.2	-0.8	0.2	0.6
Reaction time trials correct on left	0.1	0.5	1.1	0.6	0.8	1.0	-0.5	0.7	0.1
Reaction time trials on left	0.2	0.6	1.3	0.7	0.9	1.1	-0.6	0.7	0.2
Reaction time mean	0.0	0.1	0.5	0.3	-0.2	-0.2	-0.7	0.0	-0.0
Reaction time mean AUC	0.0	0.1	0.5	0.2	-0.3	-0.3	-0.7	-0.0	-0.0
Median of all reaction times	0.1	0.1	0.4	-0.3	-0.5	-0.6	-0.1	0.2	-0.2
Reaction time omissions	1.1	1.7	4.9	1.7	0.9	1.3	-2.2	0.1	0.2
Reaction time false alarm rate	0.1	0.1	0.4	-0.6	0.2	0.2	-0.0	-0.3	0.2
Reaction time premature initiation rate	1.3	2.0	3.9	2.0	1.7	1.7	-0.4	0.5	-1.2
Reaction time premature initiations	1.3	3.9	7.3	2.5	2.6	2.7	-1.1	1.3	-0.7
Std. dev. reaction times	0.3	0.9	2.8	1.3	0.5	0.5	-1.7	-0.3	0.4
Reaction time trials completed	0.2	0.6	1.3	0.7	0.9	1.1	-0.6	0.7	0.2
Reaction time trials AUC	0.1	0.3	0.9	0.5	0.7	1.0	-0.3	0.5	0.0
Run reversals in cocaine runway, females	0.7	0.8	2.3	0.5	-0.5	-0.3	0.2	-1.4	-1.5
Run reversals in cocaine runway, males	0.2	0.2	0.6	-0.6	-0.0	-0.0	0.0	0.8	0.5
Latency to leave start box in cocaine runway	0.8	1.1	1.8	-0.4	-1.2	-1.3	0.8	-1.2	-0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.1	-0.4	-0.6	0.3	-0.5	-0.5
Latency to leave start box in cocaine runway, M	0.7	0.7	1.6	-0.1	-1.1	-1.1	0.4	-1.3	-0.4
Std. dev. time between licks in bursts	0.2	0.3	0.7	-0.2	0.7	0.8	-0.5	0.4	-0.5
Total sessions with >9 infusions	1.1	1.4	3.6	-0.1	-1.7	-1.3	0.0	-1.9	-0.5
Short access day 1 total inactive lever presses	1.3	2.5	3.8	-2.0	-1.9	-1.8	1.9	-0.8	-0.4
Short access day 10 total inactive lever presses	0.0	0.3	0.8	-0.9	0.1	-0.1	0.1	0.6	0.8
Short access day 1 total infusions	1.5	2.9	6.0	-1.5	-2.4	-1.9	1.2	-2.0	-0.5
Short access day 10 total infusions	3.2	5.3	10.2	-0.8	-3.2	-2.7	1.7	-2.8	-1.7
Short access total infusions	2.8	4.0	8.1	-0.8	-2.8	-2.3	1.1	-2.7	-1.4
Short access day 1 locomotion	1.2	2.0	3.4	-1.5	-1.8	-1.3	1.5	-1.4	-0.7
Short access day 10 total locomotion	0.7	2.6	4.0	-1.2	-2.0	-1.8	2.0	-1.0	-1.5
Short access total locomotion	2.1	3.1	5.6	-1.4	-2.4	-2.0	1.8	-1.5	-1.3
One hour access (0.3 mA shock)	5.2	6.2	12.4	-3.0	-2.8	-2.4	3.5	-1.0	-1.2
Compulsive drug intake	2.7	4.0	8.7	1.5	3.0	2.7	-1.6	1.7	0.6
One hour access (shock baseline)	2.9	7.6	13.2	-3.2	-3.6	-3.1	3.2	-1.3	-0.7
Social response proportion	0.2	0.3	1.0	1.0	0.1	0.4	-0.7	0.4	-0.0
Social responses	0.6	0.8	1.4	0.6	0.9	1.2	-0.9	0.8	0.8
Social time	0.4	0.6	1.3	0.7	0.9	0.8	-1.1	0.4	0.3
Soleus weight	1.4	4.2	13.8	-3.7	-2.0	-1.9	1.8	0.0	0.7
Bone: stiffness	0.8	1.5	4.7	2.2	-0.5	-0.3	-0.1	-1.7	-1.1
Tibialis anterior weight	3.9	13.4	40.4	6.4	3.6	3.6	-3.4	0.7	-1.4
Time to tail flick, vehicle, before self-admin	1.4	1.7	3.3	0.6	-1.0	-1.2	1.6	-1.3	-1.8
Time to tail flick, vehicle, after self-admin	0.7	1.4	3.8	0.8	-0.6	-0.6	0.0	-1.7	-2.0
Time to tail flick, test, before self-admin	3.0	3.4	4.6	-1.6	-1.7	-1.9	2.2	-1.8	-1.9
Time to tail flick, test, after self-admin	0.2	0.3	1.0	0.2	0.0	0.1	-0.2	-1.0	0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	1.1	0.5	0.4	0.4	-1.1	-0.6	-0.3
Delta time to tail flick, test, before/after SA	3.3	4.0	5.1	1.5	2.2	2.3	-2.2	1.5	2.2
Tibia length	0.2	0.6	2.9	1.7	0.4	0.4	-0.0	0.2	-0.5
Ambulatory time before self-admin	0.1	0.3	0.8	0.8	-0.4	-0.4	0.4	-0.4	-0.9
Ambulatory time after self-admin	0.2	0.3	1.1	-0.4	-0.2	-0.3	0.6	1.0	0.1
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.1	-0.0	-0.3
Total heroin consumption	3.1	3.7	6.8	2.6	2.2	2.2	-2.2	0.8	0.5
Bone: trabecular number	0.6	1.2	2.6	1.1	-0.8	-0.7	0.7	-1.3	-1.6
Bone: trabecular spacing	0.4	0.6	1.2	-0.8	0.8	0.7	-0.7	0.4	1.1
Bone: trabecular thickness	0.5	0.7	1.4	-0.7	-1.2	-1.2	0.6	-0.6	-0.4
Bone: trabecular tissue density	1.2	2.1	6.8	-2.6	-1.0	-0.7	0.5	0.5	1.9
Water consumed over 24 hours	1.1	2.1	3.4	1.3	1.8	1.8	-1.3	1.4	0.8
Number of responses in last shaping day	0.2	0.3	0.8	-0.1	0.6	0.9	-0.6	0.2	0.1