Fgd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Fgd2	0.06	0.04	2.5e-03	0.03	0.04	0.04	0.04	1.2e-02	4.2e-03	2.2e-03	3.0e-03
2	Liver	gene expression	Fgd2	0.04	0.04	5.3e-05	0.03	0.03	0.03	0.04	1.1e-04	2.0e-04	9.4e-05	8.9e-05
3	NAcc	gene expression	Fgd2	0.05	0.04	4.2e-07	0.06	0.06	0.04	0.06	4.2e-07	2.2e-07	3.1e-05	3.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.7	1.2	1.5	-1.2	-1.0	1.0
Area under the delay curve	1.9	2.0	2.8	1.4	1.7	-1.2
BMI with tail	2.8	9.0	10.2	3.1	3.2	-2.7
BMI without tail	1.8	3.7	4.1	2.0	2.0	-1.7
Body weight	7.3	30.7	33.2	5.8	5.6	-5.3
Weight adjusted by age	1.9	2.2	3.5	1.9	1.3	-1.2
Bone surface	0.0	0.0	0.0	0.1	0.2	0.0
Bone volume	0.0	0.0	0.0	0.0	0.2	-0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.4	-0.7	0.6
Number of licking bursts	0.7	0.8	1.0	-0.9	-1.0	0.9
Context. condit. distance diff. score	0.2	0.2	0.3	-0.4	-0.3	0.5
Locomotion velocity, session 1	0.6	0.7	0.8	-0.9	-0.7	0.9
Locomotion distance, session 1	3.4	4.3	4.6	-2.1	-2.0	2.1
Locomotion velocity, session 2	0.2	0.2	0.3	-0.4	-0.4	0.5
Locomotion distance, session 2	0.8	1.2	1.2	-1.1	-1.1	1.1
Locomotion velocity, session 3	0.1	0.2	0.4	0.1	0.3	-0.6
Locomotion distance, session 3	0.4	0.5	0.8	-0.9	-0.7	0.5
Stereotopy head waving bouts, day 3	1.7	2.0	2.3	1.3	1.4	-1.5
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.6	0.6	-0.4
Locomotion velocity, session 7	0.2	0.3	0.4	-0.6	-0.6	0.1
Locomotion distance, session 7	1.4	1.8	2.3	-1.5	-1.4	1.0
Stereotopy head waving bouts, day 7	0.3	0.4	0.5	0.5	0.6	-0.7
Stereotopy head waving duration, day 7	1.0	1.2	1.5	0.9	1.1	-1.2
Locomotion velocity, session 8	0.0	0.0	0.0	0.0	0.1	-0.0
Locomotion distance, session 8	0.7	1.0	1.1	-1.0	-0.9	1.0
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.1	0.0
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	-0.2	0.0
Conditioned locomotion	1.9	2.3	3.0	1.4	1.4	-1.7
Cocaine response after cond. corrected	1.6	1.8	2.4	1.6	1.3	-1.0
Cocaine response after cond. not corrected	1.6	1.7	2.4	1.5	1.4	-1.0
Cocaine response before conditioning	0.0	0.0	0.1	-0.2	-0.2	0.0
Saline control response	0.6	0.8	0.9	0.9	0.8	-0.9
Bone: connectivity density	0.5	0.8	0.9	-1.0	-0.8	0.9
Bone: cortical apparent density	0.0	0.0	0.1	-0.2	-0.0	0.0
Bone: cortical area	0.9	1.4	1.9	1.3	1.4	-0.8
Bone: cortical porosity	0.0	0.0	0.0	0.2	0.1	-0.0
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.1	0.0
Bone: cortical thickness	0.0	0.1	0.1	0.1	0.3	0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.1	-0.1	-0.2
Bone: cortical tissue density	0.0	0.0	0.0	-0.2	0.0	-0.1
Condit. Reinf. active minus inactive responses	0.9	1.0	1.1	-1.1	-0.9	1.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	-0.0	0.2
Condit. Reinf. active responses	0.3	0.4	0.6	-0.8	-0.6	0.6
Condit. Reinf. inactive responses	0.5	0.6	0.8	-0.9	-0.8	0.6
Incentive salience index mean	0.3	0.4	0.4	-0.6	-0.5	0.7
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	-0.0	0.2
Condit. Reinf. active minus inactive responses	0.8	1.0	1.1	-1.0	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.4	-0.6	0.7
Condit. Reinf. active responses	0.8	1.1	1.2	-1.1	-1.0	0.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	0.1	-0.3
Condit. Reinf. lever presses	4.0	5.4	6.3	-2.5	-2.3	2.2
Condit. Reinf. lever reinforcers received	1.5	2.2	2.4	-1.6	-1.5	1.4
Conditioned reinforcement - actives	0.3	0.3	0.6	0.5	0.4	-0.8
Conditioned reinforcement - inactives	0.4	0.4	0.7	-0.8	-0.7	0.4
Conditioned locomotion	0.4	0.5	0.8	0.5	0.7	-0.9
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.3	-0.7
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.5	-0.3	0.1
Delay disc. indifference point, 0s delay	0.5	0.5	0.7	0.8	0.9	-0.5
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	0.6	1.1	-0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	0.1	0.2
Delay disc. indifference point, 24s delay	4.6	4.5	5.5	2.2	2.3	-1.7
Delay disc. indifference point, 4s delay	1.9	2.0	2.4	1.4	1.6	-1.3
Delay disc. indifference point, 8s delay	2.2	2.3	2.8	1.4	1.7	-1.5
Indifference point function ln k	0.1	0.1	0.1	-0.3	-0.3	0.4
Indifference point function log k	0.1	0.1	0.1	-0.3	-0.3	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.3	0.2	-0.6
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	-0.4	0.0
Patch foraging total patch changes 18 sec	0.4	0.5	0.9	0.4	0.6	-0.9
Patch foraging total patch changes 24 sec	0.5	0.6	0.8	-0.7	-0.9	0.6
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.1	0.0	-0.3
Patch foraging time to switch 0 sec	1.6	2.4	2.8	1.7	1.6	-1.4
Patch foraging water rate 0 sec	0.3	0.5	0.7	-0.8	-0.8	0.6
Patch foraging water rate 12 sec	0.1	0.2	0.2	-0.4	-0.4	0.4
Patch foraging water rate 18 sec	0.6	0.8	1.0	-1.0	-0.9	0.9
Patch foraging water rate 24 sec	0.3	0.4	0.4	-0.7	-0.6	0.6
Patch foraging water rate 6 sec	0.1	0.2	0.2	-0.4	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.0	0.2	0.1
Distance traveled before self-admin	0.6	0.6	0.8	0.8	0.7	-0.9
Distance traveled after self-admin	0.0	0.1	0.1	0.4	0.0	-0.1
Extensor digitorum longus weight	0.2	0.9	1.1	-1.0	-1.0	0.9
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.1	0.2
Bone: elastic work	0.1	0.2	0.3	0.5	0.4	-0.2
Bone: endosteal estimation	3.5	7.6	8.0	2.7	2.8	-2.8
Bone: endosteal perimeter	2.4	4.9	5.4	2.3	2.3	-2.1
Epididymis fat weight	2.2	5.2	6.2	2.5	2.3	-2.0
Delta time in closed arm before/after self-admin	1.9	1.9	2.3	1.5	1.3	-1.3
Delta time in open arm before/after self-admin	0.9	0.9	1.2	-1.1	-0.8	0.8
Diff in mean of infusions in LGA sessions	0.8	0.9	1.2	-0.7	-1.1	1.0
Delay discount exponential model param	1.6	1.6	2.4	-1.2	-1.5	1.0
Extinction: sum of active levers before priming	0.2	0.2	0.5	-0.1	-0.7	0.5
Active lever presses in extinction session 6	0.2	0.2	0.3	0.6	0.4	-0.2
Bone: final force	5.3	8.5	9.3	2.9	3.1	-2.8
Bone: final moment	4.6	7.5	8.2	2.7	2.9	-2.6
Food consumed during 24 hour testing period	0.6	0.8	1.2	1.1	0.7	-0.8
Glucose	0.2	0.3	0.7	0.8	0.5	-0.2
Heart weight	1.8	2.5	3.5	-1.3	-1.5	1.9
Delay discount hyperbolic model param	1.1	1.2	1.8	-1.0	-1.3	0.8
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.3	0.5	-0.8
Intermittent access intake escalation	0.7	0.7	1.1	0.5	0.8	-1.0
Intermittent access intake escalation 2	0.4	0.4	0.6	-0.8	-0.7	0.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.2	-0.4	0.2
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.1	0.8	0.9	-1.1
Intermitt. access escalation Index	0.2	0.2	0.4	-0.3	-0.3	0.6
Intermittent access day 1 total infusions	0.3	0.3	0.3	-0.5	-0.6	0.6
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	0.1	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.3	0.2	-0.4
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.4	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.3	0.2	-0.4
Intermittent access day 15 total locomotion	3.4	3.7	4.6	1.7	1.9	-2.1
Intermittent access total locomotion	1.1	1.2	1.8	0.8	1.1	-1.3
Intermittent access standard deviation	0.5	0.5	0.8	0.7	0.5	-0.9
Left kidney weight	3.0	8.3	8.7	2.8	3.0	-2.9
Right kidney weight	3.7	10.4	10.9	3.2	3.2	-3.3
Cocaine induced anxiety	0.2	0.2	0.3	-0.6	-0.4	0.3
Post-drug Anxiety	0.4	0.4	0.4	-0.6	-0.7	0.7
Baseline Anxiety	0.1	0.1	0.2	0.2	-0.4	0.4
Tail length	0.9	2.9	3.3	1.7	1.5	-1.8
Length with tail	2.2	8.1	8.7	2.9	2.7	-3.0
Length without tail	1.9	4.1	4.3	2.1	2.0	-2.0
Times rat made contact with spout	3.9	4.6	5.5	-2.3	-2.1	1.9
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.0	-0.2
Liver weight, left	4.1	6.6	8.6	2.1	2.6	-2.9
Liver weight, right	1.8	2.9	4.2	1.5	1.5	-2.0
Locomotor activity	0.1	0.1	0.2	0.3	0.2	-0.4
Locomotor testing distance	0.0	0.0	0.0	0.2	0.1	-0.1
Locomotor testing rearing	1.0	1.5	1.6	1.2	1.2	-1.3
Locomotion in novel chamber	0.2	0.3	0.4	-0.6	-0.3	0.6
Locomotion in novel chamber post-restriction	1.7	2.0	2.5	1.1	1.5	-1.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.0	0.3	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	1.0	1.0	0.4	-0.5
Time >=10cm from walls, locomotor time 1	1.7	1.7	1.8	1.4	1.3	-1.3
Bouts of movement, locomotor time 1	0.2	0.3	0.4	-0.6	-0.4	0.5
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.1	0.2
Rest time, locomotor task time 1	0.2	0.2	0.2	0.4	0.5	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.2	0.3	-0.3
Vertical activity count, locomotor time 1	0.6	0.6	0.7	0.7	0.8	-0.8
Time >=10cm from walls, locomotor time 2	7.2	7.6	9.7	3.1	2.4	-2.7
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.0	0.4	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.3	-0.0	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.2	0.3	-0.0
Distance moved, locomotor task time 2	1.7	1.9	2.5	1.4	1.2	-1.6
Vertical activity count, locomotor time 2	1.0	1.1	1.3	1.1	0.9	-1.1
Light reinforcement 1	1.8	3.2	3.8	1.8	1.6	-1.9
Light reinforcement 2	2.6	3.4	3.7	1.9	1.7	-1.9
Bone: marrow area	3.6	7.9	8.2	2.8	2.8	-2.9
Bone: maximum diameter	1.0	1.8	2.3	1.4	1.5	-1.0
Bone: maximum force	2.1	3.7	4.2	1.9	2.1	-1.8
Bone: maximum moment	1.7	2.9	3.4	1.7	1.8	-1.6
Mean time between licks in bursts	0.5	0.7	0.9	-0.7	-0.9	0.9
Mean num. licks in bursts	0.3	0.3	0.6	-0.7	-0.5	0.5
Cd content in liver	0.7	0.8	1.1	0.8	0.7	-1.1
Co content in liver	2.2	2.6	2.8	1.6	1.5	-1.7
Cu content in liver	3.6	4.4	4.6	-2.1	-2.1	2.1
Fe content in liver	3.8	4.6	5.1	2.0	2.1	-2.3
K content in liver	1.3	1.3	1.4	-1.1	-1.2	1.1
Mg content in liver	2.2	2.3	2.7	-1.4	-1.5	1.6
Mn content in liver	0.0	0.1	0.1	-0.2	-0.2	0.3
Na content in liver	0.3	0.3	0.5	-0.6	-0.7	0.4
Rb content in liver	0.2	0.2	0.2	0.5	0.5	-0.4
Se content in liver	2.6	3.2	3.7	-1.7	-1.8	1.9
Sr content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Zn content in liver	2.0	2.3	2.9	1.7	1.6	-1.2
Bone: minimum diameter	2.4	4.5	5.5	2.3	2.2	-1.7
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.0	0.0
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.6	0.5	-0.6
Total zone transitions, hab. session 1	3.3	4.6	5.0	-2.2	-2.1	2.0
Total locomotion distance, hab. session 1	2.0	2.8	3.0	-1.7	-1.6	1.7
Locomotion velocity, hab. session 1	1.8	2.6	2.8	-1.7	-1.5	1.7
Time in familiar zone, hab. session 2	1.2	1.2	1.4	-1.2	-1.0	1.1
Time in novel zone, hab. session 2	1.2	1.2	1.5	1.0	1.0	-1.2
Total zone transitions, hab. session 2	0.5	0.6	0.7	-0.9	-0.8	0.7
Total locomotion distance, hab. session 2	2.5	3.3	3.8	-1.9	-1.8	1.7
Locomotion velocity, hab. session 2	3.1	4.2	4.7	-2.2	-2.0	2.0
Novel to familiar place preference ratio	0.5	0.6	0.8	0.9	0.7	-0.6
Novelty place preference	0.4	0.4	0.6	0.8	0.6	-0.5
Time in novel zone, NPP test	0.5	0.5	0.7	0.8	0.7	-0.6
Total zone transitions, NPP test	1.6	2.3	2.5	-1.6	-1.5	1.5
Total locomotion distance, NPP test	1.3	1.8	2.0	-1.4	-1.3	1.3
Locomotion velocity, NPP test	2.0	2.9	3.0	-1.7	-1.7	1.7
Intraocular pressure	1.3	1.9	2.5	1.0	1.6	-1.4
Delta distance traveled before/after self-admin	0.5	0.5	0.7	-0.6	-0.8	0.8
Delta ambulatory time before/after self-admin	0.8	0.8	1.0	-0.7	-1.0	1.0
Parametrial fat weight	1.3	2.6	3.8	1.4	1.5	-1.9
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.4	0.5	-0.7
Pavlov. Cond. magazine entry latency	0.3	0.3	0.4	-0.6	-0.6	0.6
Pavlov. Cond. change in total contacts	0.6	0.6	0.7	0.8	0.9	-0.8
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	0.0	0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.3	-0.4	0.5
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.8	0.8	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	-0.0	0.2
Pavlov. Cond. response bias	0.7	0.9	1.1	-0.9	-0.9	1.0
Pavlov. Cond. lever latency	2.4	3.3	4.1	2.0	1.8	-1.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	0.4	-0.4
Pavlov. Cond. change in total contacts	1.7	2.3	3.1	-1.8	-1.4	1.3
Pavlov. Cond. index score	0.7	0.9	1.4	-1.2	-0.9	0.7
Pavlov. Cond. latency score	0.5	0.6	0.8	-0.9	-0.7	0.6
Pavlov. Cond. lever contacts	2.0	2.7	3.9	-2.0	-1.6	1.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.1	-1.0	-1.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	-0.9	-0.7	0.5
Pavlov. Cond. response bias	1.2	1.7	2.7	-1.7	-1.2	0.9
Time in closed arm before self-admin	0.4	0.4	0.5	-0.6	-0.7	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.3	-0.3
Time in open arm before self-admin	0.4	0.5	0.5	-0.7	-0.7	0.6
Time in open arm after self-admin	2.4	2.6	3.1	-1.8	-1.6	1.5
Bone: periosteal estimation	2.9	6.0	6.5	2.5	2.6	-2.3
Bone: periosteal perimeter	1.6	2.6	3.0	1.7	1.7	-1.3
Bone: post-yield work	0.2	0.3	0.4	0.5	0.6	-0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.0	-0.2	0.1
Progressive ratio test 1 inactive lever presses	0.5	0.6	0.8	0.6	0.7	-0.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.3	-0.3	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	-0.4	0.1
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.2	-1.1	-1.1	0.6
Incentive Sensitization - Responses	1.3	1.4	1.6	-1.3	-1.2	1.0
Incentive Sensitization - Breakpoint	0.8	0.8	1.1	-1.0	-0.9	0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.2	-0.8	0.8
Progressive ratio	2.3	2.7	3.6	1.2	1.7	-1.9
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.1	0.4	0.2
Seeking ratio, punishment vs. effort	1.0	1.3	2.3	-0.7	-1.0	1.5
Retroperitoneal fat weight	1.5	5.0	5.5	2.4	2.2	-2.2
Reaction time number correct	0.2	0.4	0.8	0.3	0.4	-0.9
Reaction time mean minus median	0.1	0.1	0.2	-0.0	0.5	-0.3
Reaction time mean minus median AUC	0.2	0.3	0.6	0.2	0.8	-0.4
Reaction time num false alarms	0.4	0.6	0.8	-0.8	-0.9	0.5
Reaction time num false alarms AUC	1.2	1.6	2.3	-1.2	-1.5	1.0
Reaction time trials correct on left	0.2	0.4	0.8	0.3	0.4	-0.9
Reaction time trials on left	0.2	0.3	0.8	0.3	0.4	-0.9
Reaction time mean	0.3	0.5	0.7	0.6	0.9	-0.6
Reaction time mean AUC	0.7	0.9	1.3	0.8	1.1	-0.9
Median of all reaction times	0.5	0.6	0.8	0.8	0.9	-0.7
Reaction time omissions	0.0	0.0	0.0	-0.1	0.2	-0.0
Reaction time false alarm rate	1.4	2.0	2.4	-1.2	-1.5	1.5
Reaction time premature initiation rate	0.2	0.2	0.3	-0.4	-0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	-0.1	-0.1	-0.2
Std. dev. reaction times	0.1	0.1	0.2	0.1	0.4	-0.1
Reaction time trials completed	0.2	0.3	0.8	0.3	0.4	-0.9
Reaction time trials AUC	0.2	0.3	0.8	0.3	0.5	-0.9
Run reversals in cocaine runway, females	0.2	0.2	0.3	0.2	0.5	-0.5
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.6	0.1	-0.1
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.0	-0.5	0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.0	-0.4	0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.0	0.1
Std. dev. time between licks in bursts	1.0	1.2	2.2	1.5	1.0	-0.6
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	0.0	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.4	0.4
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	-0.0	-0.0
Short access day 1 total infusions	1.2	1.2	1.5	-1.1	-1.2	1.0
Short access day 10 total infusions	0.1	0.1	0.1	-0.3	-0.4	0.2
Short access total infusions	0.0	0.0	0.0	-0.1	-0.2	-0.1
Short access day 1 locomotion	0.0	0.0	0.0	0.1	-0.2	0.2
Short access day 10 total locomotion	0.6	0.7	1.3	-0.6	-1.1	0.7
Short access total locomotion	0.0	0.0	0.1	0.2	-0.2	-0.0
One hour access (0.3 mA shock)	1.3	1.6	2.0	-1.4	-1.3	1.0
Compulsive drug intake	2.3	2.4	2.9	-1.3	-1.6	1.7
One hour access (shock baseline)	0.1	0.1	0.2	-0.0	0.3	-0.4
Social response proportion	0.1	0.1	0.2	0.5	0.2	-0.1
Social responses	0.0	0.0	0.0	0.1	-0.1	0.2
Social time	0.2	0.3	0.4	-0.6	-0.5	0.5
Soleus weight	0.6	1.7	2.5	1.6	1.3	-1.0
Bone: stiffness	1.5	2.4	2.8	1.4	1.7	-1.6
Tibialis anterior weight	0.8	2.6	2.9	-1.5	-1.7	1.7
Time to tail flick, vehicle, before self-admin	1.8	1.8	2.1	1.1	1.5	-1.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.0	-0.3	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.4	-0.4	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.5	0.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	-0.6	-0.9	1.0
Delta time to tail flick, test, before/after SA	1.3	1.2	1.4	0.8	1.2	-1.2
Tibia length	2.3	6.4	7.2	2.4	2.5	-2.7
Ambulatory time before self-admin	0.3	0.3	0.4	0.5	0.5	-0.6
Ambulatory time after self-admin	0.2	0.2	0.3	-0.3	-0.6	0.6
Bone: tissue strength	0.0	0.0	0.0	-0.1	-0.0	0.0
Total heroin consumption	1.2	1.4	2.0	-1.1	-1.4	1.0
Bone: trabecular number	1.2	1.9	2.3	-1.5	-1.3	1.3
Bone: trabecular spacing	2.0	2.5	2.6	1.6	1.6	-1.6
Bone: trabecular thickness	0.2	0.2	0.4	0.2	0.4	-0.6
Bone: trabecular tissue density	0.0	0.1	0.1	-0.4	-0.0	-0.1
Water consumed over 24 hours	0.9	1.1	1.6	-0.7	-1.1	1.3
Number of responses in last shaping day	0.6	0.7	1.1	-0.2	-1.0	0.9