Hub : Genes

Fam98a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fam98a 0.28 0.11 4.7e-07 0.07 0.06 0.08 0.05 6.9e-07 3.1e-06 1.3e-07 1.6e-05
2 Adipose mRNA stability Fam98a 0.28 0.12 3.8e-08 0.08 0.07 0.07 0.09 2.8e-09 7.4e-08 1.1e-08 7.1e-10
3 pVTA gene expression Fam98a 0.09 0.05 1.3e-03 0.08 0.08 0.08 0.08 2.3e-04 3.5e-04 1.7e-04 3.1e-04
4 LHb gene expression Fam98a 0.54 0.25 1.3e-04 0.01 0.13 0.15 0.18 1.4e-01 5.4e-04 1.9e-04 4.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.83.16.8-1.41.7-2.60.8
Area under the delay curve0.70.71.9-1.40.80.00.6
BMI with tail0.61.95.8-1.00.4-2.40.9
BMI without tail0.61.23.8-0.6-0.0-2.00.7
Body weight0.31.33.20.9-1.8-0.4-0.9
Weight adjusted by age0.40.50.70.8-0.4-0.5-0.8
Bone surface0.40.71.3-0.71.0-1.10.2
Bone volume0.50.92.0-0.80.9-1.40.1
Breakpoint value in progressive ratio session0.91.01.9-0.40.9-1.41.0
Number of licking bursts0.60.71.1-0.81.0-1.10.3
Context. condit. distance diff. score2.53.03.81.7-1.91.6-1.7
Locomotion velocity, session 10.80.82.3-0.80.5-1.50.3
Locomotion distance, session 12.93.75.8-2.41.9-1.71.5
Locomotion velocity, session 21.01.21.7-1.00.9-1.01.3
Locomotion distance, session 20.71.01.6-1.10.8-1.30.8
Locomotion velocity, session 31.21.42.4-1.41.0-1.50.5
Locomotion distance, session 32.62.85.0-1.61.2-2.21.5
Stereotopy head waving bouts, day 30.30.40.8-0.80.90.3-0.1
Stereotopy head waving duration, day 30.30.31.2-0.00.21.1-0.4
Locomotion velocity, session 72.62.95.9-1.61.3-2.41.1
Locomotion distance, session 70.50.72.4-0.50.1-1.60.1
Stereotopy head waving bouts, day 70.10.20.40.40.10.6-0.0
Stereotopy head waving duration, day 70.10.10.20.30.30.40.1
Locomotion velocity, session 80.70.92.4-0.90.5-1.50.3
Locomotion distance, session 80.50.71.50.4-1.10.2-1.2
Degree of sensitization distance1.21.22.01.2-1.00.6-1.4
Degree of sensitization stereotypy0.20.20.50.5-0.20.7-0.2
Conditioned locomotion1.61.92.9-1.71.6-1.20.8
Cocaine response after cond. corrected1.11.22.6-0.80.9-1.60.9
Cocaine response after cond. not corrected0.60.71.3-0.80.6-1.10.7
Cocaine response before conditioning0.60.72.30.0-0.61.5-0.4
Saline control response2.83.75.2-2.22.3-0.42.1
Bone: connectivity density2.23.56.7-1.62.0-2.61.0
Bone: cortical apparent density0.30.40.5-0.60.6-0.70.6
Bone: cortical area0.10.10.2-0.30.4-0.20.4
Bone: cortical porosity0.91.01.8-1.01.30.60.7
Bone: cortical porosity1.11.22.2-1.21.50.40.9
Bone: cortical thickness0.20.30.7-0.50.5-0.10.9
Bone: cortical thickness1.31.51.8-1.31.1-1.21.3
Bone: cortical tissue density0.20.30.5-0.40.5-0.70.5
Condit. Reinf. active minus inactive responses2.22.53.8-1.41.1-1.71.9
Condit. Reinf. active-inactive response ratio1.82.03.5-1.01.1-1.91.5
Condit. Reinf. active responses2.22.85.0-1.41.3-1.52.2
Condit. Reinf. inactive responses0.10.10.30.30.10.40.5
Incentive salience index mean1.51.82.2-1.51.0-1.41.4
Condit. Reinf. lever presses0.10.10.5-0.70.2-0.00.2
Condit. Reinf. active minus inactive responses0.70.91.8-1.30.9-0.20.9
Condit. Reinf. active-inactive response ratio0.30.30.5-0.60.50.70.5
Condit. Reinf. active responses0.50.71.3-1.20.60.00.9
Condit. Reinf. inactive responses0.20.30.6-0.80.2-0.40.5
Condit. Reinf. lever presses0.91.22.1-1.40.9-0.41.3
Condit. Reinf. lever reinforcers received0.81.11.9-1.40.9-0.41.3
Conditioned reinforcement - actives0.40.41.2-0.30.4-0.51.1
Conditioned reinforcement - inactives1.11.32.2-1.51.1-0.31.2
Conditioned locomotion0.10.10.3-0.5-0.2-0.10.2
Patch foraging indifference point 0 sec0.81.33.4-1.20.5-1.80.5
Patch foraging indifference point AUC1.21.41.9-0.81.4-1.31.2
Delay disc. indifference point, 0s delay1.41.63.10.7-1.31.8-1.1
Delay disc. indifference point, 16s delay1.01.01.8-1.41.1-0.21.0
Delay disc. indifference point, 2s delay0.70.81.5-0.90.90.11.2
Delay disc. indifference point, 24s delay1.41.42.8-1.71.3-0.31.0
Delay disc. indifference point, 4s delay0.20.20.4-0.0-0.40.6-0.5
Delay disc. indifference point, 8s delay0.80.82.2-1.50.8-0.40.4
Indifference point function ln k0.60.81.11.0-1.00.6-0.9
Indifference point function log k0.60.81.11.0-1.00.6-0.9
Patch foraging total patch changes 0 sec0.91.53.5-1.30.6-1.90.6
Patch foraging total patch changes 12 sec0.40.51.7-0.2-0.2-1.3-0.3
Patch foraging total patch changes 18 sec2.43.15.0-1.71.6-2.21.5
Patch foraging total patch changes 24 sec0.20.20.6-0.30.5-0.00.8
Patch foraging total patch changes 6 sec0.30.51.4-0.40.6-1.20.3
Patch foraging time to switch 0 sec0.81.21.6-1.21.1-0.81.3
Patch foraging water rate 0 sec0.20.40.90.4-0.60.1-1.0
Patch foraging water rate 12 sec1.82.85.91.1-1.52.4-1.4
Patch foraging water rate 18 sec1.52.03.81.3-1.22.0-1.0
Patch foraging water rate 24 sec1.31.73.41.8-1.31.3-0.5
Patch foraging water rate 6 sec1.62.43.31.0-1.41.8-1.8
Seeking ratio, delayed vs. immediate footshock0.10.10.20.3-0.40.2-0.1
Distance traveled before self-admin1.41.42.31.1-1.50.3-1.5
Distance traveled after self-admin0.00.00.00.2-0.20.20.1
Extensor digitorum longus weight2.911.216.1-3.73.0-4.02.4
Bone: elastic displacement0.30.30.90.3-0.50.0-1.0
Bone: elastic work0.00.10.1-0.30.2-0.10.3
Bone: endosteal estimation0.10.30.70.4-0.5-0.2-0.9
Bone: endosteal perimeter0.40.81.10.9-0.90.8-1.0
Epididymis fat weight3.27.511.83.4-3.21.2-2.5
Delta time in closed arm before/after self-admin0.40.41.00.5-0.5-0.1-1.0
Delta time in open arm before/after self-admin1.81.73.1-1.11.2-1.01.8
Diff in mean of infusions in LGA sessions0.80.92.2-0.50.9-1.50.6
Delay discount exponential model param1.01.02.61.6-1.00.2-0.7
Extinction: sum of active levers before priming2.22.23.61.8-1.90.2-1.4
Active lever presses in extinction session 60.30.30.60.30.20.80.7
Bone: final force1.62.63.4-1.71.8-1.31.6
Bone: final moment1.22.02.5-1.41.6-1.21.4
Food consumed during 24 hour testing period0.10.10.30.4-0.00.4-0.5
Glucose0.00.10.20.50.2-0.10.0
Heart weight2.23.14.31.1-2.11.8-1.9
Delay discount hyperbolic model param0.91.02.31.5-1.00.2-0.7
Intermittent access intake day 1-15 change0.20.20.6-0.10.10.80.2
Intermittent access intake escalation0.40.40.70.6-0.60.8-0.3
Intermittent access intake escalation 20.30.30.60.6-0.20.70.0
Intermitt. access day 1 inactive lever presses0.40.41.3-0.2-0.61.2-0.0
Intermitt. access day 15 inactive lever presses0.30.30.7-0.10.30.70.9
Intermitt. access escalation Index2.62.33.11.8-1.61.5-1.2
Intermittent access day 1 total infusions1.21.42.1-1.41.1-1.30.6
Intermittent access day 15 total infusions0.00.10.1-0.30.1-0.3-0.1
Intermittent access terminal intake (last 3 days)0.30.40.6-0.80.7-0.30.5
Intermittent access total infusions0.50.61.3-1.10.8-0.60.3
Intermittent access day 1 locomotion2.02.14.0-2.01.4-1.11.0
Intermittent access day 15 total locomotion0.80.92.0-1.40.5-1.10.2
Intermittent access total locomotion0.91.02.4-1.50.8-0.90.5
Intermittent access standard deviation2.02.13.20.8-1.51.8-1.4
Left kidney weight1.13.24.21.7-1.72.0-1.7
Right kidney weight2.36.48.92.3-3.02.2-2.6
Cocaine induced anxiety0.20.20.40.5-0.4-0.60.0
Post-drug Anxiety0.60.71.71.3-0.90.0-0.5
Baseline Anxiety0.40.40.50.6-0.50.7-0.7
Tail length1.03.03.71.7-1.91.8-1.4
Length with tail1.24.35.51.9-2.32.1-1.8
Length without tail0.30.61.20.5-0.71.1-0.8
Times rat made contact with spout1.21.41.7-1.11.31.11.2
Lifetime Intake0.50.61.3-1.10.7-0.80.2
Liver weight, left1.22.03.61.3-1.90.7-1.4
Liver weight, right5.49.011.22.8-3.32.8-3.0
Locomotor activity0.30.51.3-0.80.2-1.20.1
Locomotor testing distance0.61.02.9-0.80.4-1.70.3
Locomotor testing rearing0.40.61.0-0.90.4-1.00.5
Locomotion in novel chamber0.30.40.80.3-0.80.90.0
Locomotion in novel chamber post-restriction0.60.71.50.10.21.21.2
Fecal boli incidents, locomotor time 10.00.00.1-0.10.30.0-0.0
Change in fecal boli incidents, locomotor task1.41.31.91.4-1.21.2-0.5
Time >=10cm from walls, locomotor time 11.01.02.10.7-1.10.3-1.5
Bouts of movement, locomotor time 10.40.40.8-0.3-0.20.9-0.8
Total resting periods, locomotor time 10.40.41.1-0.2-0.11.1-0.7
Rest time, locomotor task time 10.70.81.50.4-0.61.2-1.1
Distance moved, locomotor task time 10.40.51.01.0-0.7-0.5-0.4
Vertical activity count, locomotor time 10.10.10.30.3-0.1-0.10.6
Time >=10cm from walls, locomotor time 20.80.81.61.0-0.80.0-1.3
Bouts of movement, locomotor time 21.71.84.01.1-1.22.0-0.9
Total resting periods, locomotor time 21.41.53.01.0-1.11.7-0.9
Rest time, locomotor task time 20.60.71.8-1.30.7-0.40.5
Distance moved, locomotor task time 20.91.12.31.5-1.00.2-0.9
Vertical activity count, locomotor time 20.60.61.91.4-0.60.2-0.3
Light reinforcement 13.25.98.1-2.82.5-1.82.5
Light reinforcement 20.00.10.2-0.5-0.1-0.1-0.1
Bone: marrow area0.10.30.70.4-0.5-0.2-0.8
Bone: maximum diameter0.30.61.0-0.81.0-0.50.6
Bone: maximum force0.40.71.9-0.60.7-1.40.4
Bone: maximum moment0.20.41.3-0.20.3-1.10.1
Mean time between licks in bursts1.31.82.81.6-1.40.0-1.7
Mean num. licks in bursts0.70.83.00.1-0.11.70.5
Cd content in liver0.10.10.20.1-0.10.30.5
Co content in liver0.91.11.7-1.30.91.00.9
Cu content in liver0.00.00.1-0.1-0.20.0-0.3
Fe content in liver0.60.71.51.0-0.70.2-1.2
K content in liver0.70.71.10.2-0.90.9-1.0
Mg content in liver0.30.30.5-0.4-0.50.7-0.4
Mn content in liver0.10.10.2-0.4-0.30.5-0.1
Na content in liver0.20.20.40.3-0.20.7-0.4
Rb content in liver0.40.61.4-0.50.70.11.2
Se content in liver1.11.42.81.1-1.11.7-0.5
Sr content in liver0.70.61.7-0.60.70.21.3
Zn content in liver1.92.14.50.9-1.22.1-1.4
Bone: minimum diameter0.10.10.30.5-0.3-0.2-0.3
Time in familiar zone, hab. session 10.20.20.40.3-0.70.2-0.6
Time in novel zone, hab. session 10.10.10.3-0.00.2-0.50.1
Total zone transitions, hab. session 10.60.92.0-1.40.8-0.11.0
Total locomotion distance, hab. session 10.60.81.3-1.00.70.61.1
Locomotion velocity, hab. session 10.81.11.7-1.20.80.81.3
Time in familiar zone, hab. session 20.10.10.30.4-0.10.6-0.1
Time in novel zone, hab. session 20.30.30.9-0.0-0.1-1.0-0.3
Total zone transitions, hab. session 21.01.31.9-1.41.3-0.61.2
Total locomotion distance, hab. session 20.70.91.5-1.01.00.01.2
Locomotion velocity, hab. session 20.60.81.5-1.00.9-0.11.2
Novel to familiar place preference ratio0.70.71.50.8-0.5-0.7-1.2
Novelty place preference0.90.91.91.1-0.6-0.5-1.4
Time in novel zone, NPP test0.80.81.70.9-0.5-0.6-1.3
Total zone transitions, NPP test1.42.03.5-1.91.4-1.11.1
Total locomotion distance, NPP test2.94.06.3-2.52.0-1.22.0
Locomotion velocity, NPP test2.33.24.7-2.21.8-1.02.0
Intraocular pressure0.70.92.1-0.80.5-1.40.8
Delta distance traveled before/after self-admin0.60.71.5-0.60.9-0.21.2
Delta ambulatory time before/after self-admin2.22.45.0-1.11.80.32.2
Parametrial fat weight1.22.24.12.0-2.00.5-0.9
Pavlov. Cond. lever latency0.40.51.71.3-0.5-0.1-0.4
Pavlov. Cond. magazine entry latency2.83.66.3-2.52.0-0.91.9
Pavlov. Cond. change in total contacts0.50.50.9-0.90.6-0.10.8
Pavlov. Cond. index score1.41.74.4-2.11.2-0.50.9
Pavlov. Cond. latency score1.21.64.1-2.01.2-0.40.8
Pavlov. Cond. lever contacts0.20.31.0-1.00.20.00.0
Pavlov. Cond. magazine entry number3.84.77.42.7-2.41.1-2.1
Pavlov. Cond. intertrial magazine entries0.20.20.80.9-0.30.1-0.2
Pavlov. Cond. lever-magazine prob. diff.1.51.94.5-2.11.3-0.61.0
Pavlov. Cond. response bias1.82.14.0-2.01.5-0.71.3
Pavlov. Cond. lever latency0.20.30.60.7-0.40.5-0.6
Pavlov. Cond. magazine entry latency0.60.60.8-0.70.8-0.90.7
Pavlov. Cond. change in total contacts0.10.10.3-0.50.20.20.0
Pavlov. Cond. index score0.70.91.4-1.21.0-0.60.9
Pavlov. Cond. latency score0.70.91.2-1.11.1-0.60.8
Pavlov. Cond. lever contacts0.20.30.6-0.70.3-0.00.6
Pavlov. Cond. magazine entry number0.30.40.80.5-0.60.9-0.2
Pavlov. Cond. intertrial magazine entries1.41.92.61.5-1.61.3-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.61.0-1.00.8-0.50.6
Pavlov. Cond. response bias0.60.81.3-1.10.7-0.60.9
Time in closed arm before self-admin0.10.10.20.1-0.50.0-0.1
Time in closed arm after self-admin0.60.61.00.6-1.00.6-0.8
Time in open arm before self-admin0.40.51.50.2-0.50.2-1.2
Time in open arm after self-admin0.80.91.7-0.80.9-1.30.5
Bone: periosteal estimation0.00.00.10.0-0.0-0.3-0.2
Bone: periosteal perimeter0.10.20.60.2-0.30.8-0.3
Bone: post-yield work0.50.71.7-0.90.6-1.30.4
Progressive ratio test 1 active lever presses0.91.01.8-1.31.0-0.90.3
Progressive ratio test 1 breakpoint0.60.71.5-1.20.9-0.50.2
Progressive ratio test 1 inactive lever presses0.80.91.5-1.21.20.10.7
Progressive ratio test 2 active lever presses0.80.92.1-1.50.9-0.60.4
Progressive ratio test 2 breakpoint1.21.32.6-1.61.3-0.70.8
Progressive ratio test 2 inactive lever presses0.70.81.4-1.20.90.10.9
Incentive Sensitization - Responses1.11.11.9-1.41.0-0.51.0
Incentive Sensitization - Breakpoint0.90.91.6-1.30.9-0.41.0
Sum of active levers in priming session hrs 5-60.60.61.00.8-0.8-0.2-1.0
Progressive ratio0.60.71.7-1.30.7-0.20.7
Food seeking constrained by brief footshock0.00.00.0-0.00.1-0.10.2
Seeking ratio, punishment vs. effort0.70.91.91.4-0.80.5-0.8
Retroperitoneal fat weight4.514.723.64.8-4.91.3-3.2
Reaction time number correct0.20.30.6-0.60.80.30.0
Reaction time mean minus median0.70.92.10.51.0-0.51.5
Reaction time mean minus median AUC0.81.02.20.31.3-0.51.5
Reaction time num false alarms0.10.20.30.30.6-0.20.5
Reaction time num false alarms AUC0.10.20.50.10.5-0.10.7
Reaction time trials correct on left0.20.30.6-0.60.80.30.0
Reaction time trials on left0.20.30.7-0.70.90.20.1
Reaction time mean0.30.41.11.0-0.6-0.3-0.3
Reaction time mean AUC0.50.61.51.2-0.80.0-0.5
Median of all reaction times0.40.60.80.8-0.9-0.4-0.8
Reaction time omissions0.91.31.6-1.01.1-1.11.3
Reaction time false alarm rate0.10.10.30.5-0.1-0.10.5
Reaction time premature initiation rate0.60.81.0-1.00.51.00.9
Reaction time premature initiations0.71.01.7-1.31.00.80.9
Std. dev. reaction times0.20.30.50.70.4-0.40.7
Reaction time trials completed0.20.30.7-0.70.90.20.1
Reaction time trials AUC0.30.40.9-0.81.00.10.2
Run reversals in cocaine runway, females0.10.10.1-0.30.30.1-0.0
Run reversals in cocaine runway, males1.01.01.7-1.01.3-0.11.1
Latency to leave start box in cocaine runway1.11.21.5-1.01.1-1.20.9
Latency to leave start box in cocaine runway, F0.40.51.0-0.70.6-1.00.3
Latency to leave start box in cocaine runway, M0.20.20.2-0.50.4-0.50.2
Std. dev. time between licks in bursts0.40.40.7-0.60.6-0.80.5
Total sessions with >9 infusions0.50.61.4-1.20.8-0.50.0
Short access day 1 total inactive lever presses0.10.20.3-0.30.30.50.5
Short access day 10 total inactive lever presses0.40.41.00.6-0.61.00.4
Short access day 1 total infusions0.30.30.8-0.50.1-0.9-0.5
Short access day 10 total infusions1.21.42.6-1.31.0-1.60.3
Short access total infusions0.40.50.8-0.90.7-0.70.1
Short access day 1 locomotion2.83.05.2-2.32.0-0.81.4
Short access day 10 total locomotion1.51.72.6-1.61.1-1.21.3
Short access total locomotion2.02.14.0-2.01.5-0.81.3
One hour access (0.3 mA shock)0.20.20.3-0.50.6-0.60.2
Compulsive drug intake4.95.06.32.5-2.51.5-2.3
One hour access (shock baseline)1.92.22.8-1.61.7-1.01.5
Social response proportion0.60.71.6-0.4-0.8-1.3-0.4
Social responses0.20.20.3-0.4-0.6-0.4-0.4
Social time0.10.10.1-0.4-0.1-0.3-0.1
Soleus weight1.44.18.1-2.92.0-1.61.2
Bone: stiffness0.10.20.60.3-0.1-0.8-0.1
Tibialis anterior weight5.819.829.2-4.74.1-5.43.4
Time to tail flick, vehicle, before self-admin2.42.43.21.7-1.81.1-1.6
Time to tail flick, vehicle, after self-admin1.82.02.61.5-1.51.6-0.9
Time to tail flick, test, before self-admin1.11.11.4-1.20.81.11.0
Time to tail flick, test, after self-admin2.72.87.01.0-1.52.7-1.0
Delta time to tail flick, vehicle, before/after SA0.20.20.50.10.10.70.6
Delta time to tail flick, test, before/after SA1.61.42.01.3-1.40.9-1.1
Tibia length1.33.67.51.6-2.02.7-0.6
Ambulatory time before self-admin0.90.91.50.9-1.2-0.0-1.1
Ambulatory time after self-admin0.10.10.40.20.20.30.7
Bone: tissue strength0.10.10.30.1-0.3-0.5-0.3
Total heroin consumption0.40.51.4-0.40.5-1.20.6
Bone: trabecular number1.21.83.8-1.21.3-1.90.5
Bone: trabecular spacing0.91.22.90.9-1.01.7-0.5
Bone: trabecular thickness0.80.93.3-0.30.1-1.8-0.4
Bone: trabecular tissue density0.71.01.9-1.21.4-0.50.6
Water consumed over 24 hours2.63.14.5-1.82.1-0.91.9
Number of responses in last shaping day0.40.40.8-0.70.50.90.2