Fam83b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	Fam83b	0.34	0.16	4.8e-03	0.03	0.03	0.02	0	1.1e-01	1.2e-01	1.8e-01	2.6e-01
2	Adipose	gene expression	Fam83b	0.21	0.08	0.0e+00	0.12	0.16	0.14	0.16	7.5e-13	2.7e-17	1.2e-15	5.8e-17
3	NAcc	gene expression	Fam83b	0.05	0.03	1.4e-05	0.05	0.03	0.03	0.04	2.6e-06	4.0e-04	3.1e-04	3.3e-05
4	Brain	gene expression	Fam83b	0.02	0.01	9.9e-03	0.01	0	-0	0	6.4e-02	1.1e-01	3.8e-01	1.6e-01
5	BLA	gene expression	Fam83b	0.06	0.04	4.5e-03	0.02	0.03	0.02	0.02	3.1e-02	6.8e-03	3.7e-02	2.3e-02
6	PL	gene expression	Fam83b	0.04	0.02	2.1e-05	0.03	0.04	0.02	0.03	1.4e-04	7.6e-05	1.1e-03	3.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	0.8	-0.2	0.7	-0.9	-0.8	0.5	0.4
Area under the delay curve	0.7	0.8	1.5	-1.2	1.1	-0.7	-0.7	0.7	0.7
BMI with tail	3.3	10.6	14.6	-2.4	3.8	-3.8	-3.3	3.0	2.9
BMI without tail	1.5	3.2	5.5	-1.1	2.3	-1.2	-2.4	1.6	1.7
Body weight	1.9	8.1	14.2	-1.8	3.8	-3.0	-3.1	2.5	2.4
Weight adjusted by age	1.7	1.9	3.0	-1.6	1.7	-1.1	-1.3	1.2	1.2
Bone surface	2.7	4.7	6.9	-1.8	2.4	-2.6	-2.3	1.9	1.7
Bone volume	1.1	1.9	2.7	-1.1	1.6	-1.7	-1.5	1.1	0.9
Breakpoint value in progressive ratio session	2.3	2.5	5.2	-2.3	1.3	-1.1	-1.4	1.5	1.6
Number of licking bursts	2.6	3.1	3.6	-1.9	1.7	-1.7	-1.7	1.8	1.7
Context. condit. distance diff. score	0.1	0.1	0.4	-0.6	0.1	0.2	0.2	-0.3	-0.3
Locomotion velocity, session 1	0.1	0.1	0.6	-0.8	0.3	0.1	0.1	0.0	0.0
Locomotion distance, session 1	0.1	0.2	0.9	-0.1	0.0	0.9	-0.0	-0.2	-0.1
Locomotion velocity, session 2	0.4	0.4	2.0	-1.4	0.5	0.1	-0.2	0.3	0.3
Locomotion distance, session 2	0.3	0.4	0.9	-0.9	0.6	0.9	-0.5	0.3	0.4
Locomotion velocity, session 3	0.7	0.8	1.4	-0.9	1.0	-0.2	-1.2	0.9	0.9
Locomotion distance, session 3	0.1	0.1	0.3	0.1	-0.5	0.6	0.2	-0.2	-0.1
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.5	-0.7	-0.3	0.5	0.0	-0.1
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.2	-0.3
Locomotion velocity, session 7	0.1	0.2	0.4	-0.4	-0.0	0.1	-0.3	0.6	0.6
Locomotion distance, session 7	0.2	0.2	0.8	-0.9	0.0	0.8	0.2	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	-0.4	0.5	-0.8	-0.8	0.8	0.7
Stereotopy head waving duration, day 7	0.9	1.0	1.3	-0.7	1.0	-1.1	-1.1	1.1	1.0
Locomotion velocity, session 8	0.8	1.0	1.5	-1.2	1.1	-0.5	-1.1	0.9	0.9
Locomotion distance, session 8	0.4	0.6	2.0	-1.4	0.7	0.8	-0.5	0.4	0.4
Degree of sensitization distance	0.3	0.3	0.4	-0.6	-0.0	0.6	0.6	-0.6	-0.6
Degree of sensitization stereotypy	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.9	0.8	0.7
Conditioned locomotion	0.3	0.3	1.2	1.1	-0.6	0.4	0.3	0.2	0.4
Cocaine response after cond. corrected	0.4	0.5	1.2	-1.0	0.6	-1.1	-0.2	0.4	0.4
Cocaine response after cond. not corrected	0.4	0.5	1.7	-0.8	0.7	-1.3	-0.1	0.3	0.2
Cocaine response before conditioning	0.5	0.6	1.1	-0.7	1.1	-0.7	-0.9	0.7	0.6
Saline control response	0.5	0.7	0.9	0.9	-0.9	-0.6	1.0	-0.7	-0.8
Bone: connectivity density	0.4	0.6	1.2	-0.0	0.6	-0.7	-1.1	0.9	0.8
Bone: cortical apparent density	4.0	5.3	7.1	2.7	-2.5	2.4	2.3	-2.0	-1.9
Bone: cortical area	0.5	0.7	1.5	0.7	-0.6	-0.2	1.0	-1.1	-1.2
Bone: cortical porosity	0.2	0.2	0.7	0.0	-0.3	-0.8	-0.0	0.5	0.5
Bone: cortical porosity	0.2	0.2	0.4	0.1	-0.3	-0.6	-0.0	0.5	0.5
Bone: cortical thickness	3.6	5.9	7.6	2.8	-2.7	1.5	2.7	-2.4	-2.4
Bone: cortical thickness	1.3	1.5	2.3	1.2	-1.5	0.3	1.5	-1.2	-1.2
Bone: cortical tissue density	3.7	4.9	6.5	2.5	-2.4	2.3	2.2	-1.9	-1.8
Condit. Reinf. active minus inactive responses	1.4	1.6	2.8	-1.2	1.4	-0.3	-1.7	1.2	1.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	-0.2	0.4	-0.9	-0.3	0.1	0.1
Condit. Reinf. active responses	2.3	2.8	4.2	-1.8	1.8	-0.1	-2.1	1.6	1.8
Condit. Reinf. inactive responses	1.1	1.3	2.1	-1.5	1.1	1.0	-1.1	1.0	1.1
Incentive salience index mean	1.9	2.3	3.5	-1.8	1.8	-0.5	-1.9	1.3	1.4
Condit. Reinf. lever presses	1.3	1.7	3.5	-1.9	1.5	-0.5	-1.3	1.1	1.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.2	0.1	0.1	0.4	-0.8	-0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.6	-0.2	-0.8	0.2	-0.4	-0.5
Condit. Reinf. active responses	0.2	0.2	0.8	-0.9	0.7	0.0	-0.1	-0.3	-0.3
Condit. Reinf. inactive responses	0.3	0.3	1.0	-1.0	0.7	0.7	-0.1	-0.3	-0.2
Condit. Reinf. lever presses	0.4	0.6	1.5	-0.3	-0.1	-0.2	0.9	-1.0	-1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	-0.5	0.2	0.4	0.5	-0.9	-0.9
Conditioned reinforcement - actives	0.7	0.7	1.2	-0.7	0.5	-0.9	-0.6	1.1	1.0
Conditioned reinforcement - inactives	0.5	0.6	1.1	-0.3	0.6	-0.3	-0.9	1.0	1.0
Conditioned locomotion	0.2	0.2	0.5	0.6	-0.7	-0.1	0.5	-0.3	-0.3
Patch foraging indifference point 0 sec	0.6	1.0	1.4	1.2	-0.6	0.7	1.0	-1.1	-1.2
Patch foraging indifference point AUC	0.5	0.6	1.6	0.4	-0.2	1.3	0.5	-0.9	-0.8
Delay disc. indifference point, 0s delay	0.3	0.4	0.9	-0.2	0.7	0.8	-0.9	0.3	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.2	-0.5	0.1	0.5	-0.3	-0.3
Delay disc. indifference point, 2s delay	0.9	1.1	1.6	-0.6	1.3	-1.2	-1.0	1.0	0.9
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.6	0.3	-0.7	-0.1	0.7	0.7
Delay disc. indifference point, 4s delay	1.1	1.1	2.2	-1.1	1.5	-1.0	-1.0	0.8	0.7
Delay disc. indifference point, 8s delay	0.9	0.9	2.4	-1.6	1.4	-0.3	-0.8	0.4	0.4
Indifference point function ln k	0.1	0.1	0.3	-0.4	0.3	-0.6	-0.2	0.3	0.1
Indifference point function log k	0.1	0.1	0.3	-0.4	0.3	-0.6	-0.2	0.3	0.1
Patch foraging total patch changes 0 sec	0.8	1.3	1.8	1.3	-0.8	0.9	1.2	-1.3	-1.3
Patch foraging total patch changes 12 sec	2.8	3.6	4.7	2.1	-1.4	1.8	1.7	-2.2	-2.1
Patch foraging total patch changes 18 sec	1.0	1.3	2.1	1.4	-0.9	0.6	1.1	-1.3	-1.3
Patch foraging total patch changes 24 sec	0.4	0.5	2.2	0.5	-0.2	1.5	0.3	-0.5	-0.3
Patch foraging total patch changes 6 sec	0.5	0.7	2.0	0.6	-0.6	1.4	0.6	-0.8	-0.6
Patch foraging time to switch 0 sec	0.7	1.2	2.3	0.1	0.0	-1.4	-0.7	1.5	1.5
Patch foraging water rate 0 sec	0.3	0.4	1.1	-0.1	0.3	0.5	0.4	-1.0	-1.0
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.4	0.6	0.7	-0.1	-0.7	-0.7
Patch foraging water rate 18 sec	0.2	0.3	1.1	1.1	-0.1	0.7	-0.0	-0.5	-0.4
Patch foraging water rate 24 sec	0.3	0.4	0.7	0.6	-0.4	0.5	0.3	-0.8	-0.8
Patch foraging water rate 6 sec	1.0	1.5	2.5	-1.6	1.6	-1.0	-1.3	0.8	0.8
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	5.3	-2.3	1.5	-0.4	-0.3	0.6	0.5
Distance traveled before self-admin	0.6	0.6	1.2	-0.9	1.1	-0.7	-0.7	0.6	0.4
Distance traveled after self-admin	3.1	3.4	5.8	-2.4	2.0	-1.9	-1.3	1.7	1.6
Extensor digitorum longus weight	1.1	4.1	7.6	-2.4	2.7	-1.0	-2.3	1.6	1.7
Bone: elastic displacement	0.1	0.1	0.4	0.7	-0.1	0.2	0.1	-0.4	-0.4
Bone: elastic work	0.3	0.3	0.7	0.7	-0.3	0.1	0.4	-0.8	-0.9
Bone: endosteal estimation	4.3	9.4	13.7	-3.7	3.4	-3.1	-2.9	2.6	2.5
Bone: endosteal perimeter	2.4	4.9	6.3	-2.3	2.5	-2.2	-2.2	2.0	1.9
Epididymis fat weight	2.2	5.2	7.9	2.8	-2.3	2.7	1.9	-2.0	-1.7
Delta time in closed arm before/after self-admin	0.8	0.8	1.7	1.3	-1.0	0.6	0.7	-0.8	-0.7
Delta time in open arm before/after self-admin	1.2	1.1	2.0	0.7	-1.4	1.1	1.0	-1.0	-1.0
Diff in mean of infusions in LGA sessions	3.2	3.5	4.9	-2.2	1.8	-2.1	-1.6	1.8	1.7
Delay discount exponential model param	1.1	1.1	2.0	1.4	-1.3	1.0	0.8	-0.9	-0.8
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.2	-0.6	0.1	0.3	-0.2	-0.2
Active lever presses in extinction session 6	0.4	0.4	2.0	-1.4	0.1	-0.0	0.2	0.4	0.4
Bone: final force	0.1	0.2	0.3	-0.1	-0.0	0.4	0.5	-0.5	-0.6
Bone: final moment	0.2	0.3	0.5	0.3	-0.4	0.4	0.7	-0.7	-0.7
Food consumed during 24 hour testing period	1.0	1.2	3.4	-1.4	1.3	-1.8	-0.3	0.4	0.2
Glucose	0.1	0.2	0.3	0.5	-0.4	-0.2	0.1	0.5	0.5
Heart weight	0.2	0.3	0.5	0.7	0.0	0.7	0.2	-0.6	-0.5
Delay discount hyperbolic model param	1.0	1.0	1.7	1.3	-1.3	1.0	0.8	-0.8	-0.8
Intermittent access intake day 1-15 change	0.3	0.3	1.1	-1.1	0.5	0.1	0.0	0.4	0.5
Intermittent access intake escalation	0.9	0.8	2.6	-1.6	1.0	-0.4	-0.3	0.8	0.8
Intermittent access intake escalation 2	1.3	1.3	4.1	-2.0	1.3	-0.5	-0.7	0.8	0.9
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.6	-0.0	-0.4	0.9	0.8	-1.2	-1.3
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.6	-0.3	0.3	-0.1	-0.7	0.5	0.6
Intermitt. access escalation Index	2.2	1.9	4.3	-0.9	1.2	-2.1	-1.0	1.4	1.4
Intermittent access day 1 total infusions	0.8	0.9	2.4	1.6	-1.3	-0.3	1.0	-0.5	-0.6
Intermittent access day 15 total infusions	0.4	0.4	1.1	-0.2	0.2	-1.0	-0.2	0.8	0.7
Intermittent access terminal intake (last 3 days)	1.2	1.3	3.0	-0.7	0.8	-1.7	-0.7	1.3	1.2
Intermittent access total infusions	0.3	0.3	1.0	0.5	-0.5	-1.0	0.5	0.1	-0.1
Intermittent access day 1 locomotion	1.3	1.3	2.9	1.7	-1.4	0.0	1.3	-0.8	-0.8
Intermittent access day 15 total locomotion	0.2	0.2	0.6	0.4	-0.7	-0.1	0.8	-0.3	-0.4
Intermittent access total locomotion	0.4	0.5	1.3	0.0	-0.7	-0.2	1.1	-0.6	-0.8
Intermittent access standard deviation	0.2	0.2	0.5	-0.6	0.7	-0.4	-0.3	0.4	0.4
Left kidney weight	0.1	0.3	0.6	0.5	0.7	0.5	0.0	-0.6	-0.7
Right kidney weight	0.3	0.8	2.8	-0.1	1.7	-0.6	-1.0	0.6	0.5
Cocaine induced anxiety	1.9	2.2	3.2	-0.9	1.1	-1.3	-1.8	1.8	1.8
Post-drug Anxiety	0.4	0.4	1.1	0.4	0.1	0.3	-1.1	0.7	0.8
Baseline Anxiety	5.2	5.5	6.7	2.4	-2.0	2.6	2.1	-2.5	-2.4
Tail length	0.1	0.4	1.4	-0.0	0.6	1.2	-0.6	-0.1	0.0
Length with tail	0.1	0.4	1.5	-0.4	1.2	0.1	-0.7	0.3	0.3
Length without tail	0.4	1.0	3.3	-0.6	1.2	-1.8	-0.4	0.5	0.3
Times rat made contact with spout	0.3	0.3	0.6	-0.6	0.3	-0.4	0.5	-0.6	-0.8
Lifetime Intake	0.4	0.5	1.1	1.0	-0.7	-1.0	0.4	0.3	0.2
Liver weight, left	0.1	0.1	0.2	-0.3	-0.1	0.3	0.3	-0.4	-0.5
Liver weight, right	0.0	0.1	0.3	0.1	0.6	0.1	-0.4	0.0	0.1
Locomotor activity	0.1	0.2	0.5	0.7	0.0	-0.4	0.1	-0.4	-0.4
Locomotor testing distance	0.1	0.2	0.5	0.7	0.1	-0.5	-0.2	-0.3	-0.2
Locomotor testing rearing	0.2	0.3	1.1	0.4	0.3	-1.1	-0.4	0.0	0.0
Locomotion in novel chamber	0.9	1.1	2.1	0.4	-1.2	1.0	1.4	-0.9	-1.0
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	0.2	0.3	-0.7	-0.3	0.5	0.5
Fecal boli incidents, locomotor time 1	2.9	3.2	3.8	-1.3	1.8	-1.8	-1.9	1.9	1.9
Change in fecal boli incidents, locomotor task	2.2	2.1	3.9	0.6	-1.1	1.4	1.4	-1.8	-2.0
Time >=10cm from walls, locomotor time 1	2.1	2.1	2.5	-1.0	1.5	-1.6	-1.5	1.6	1.6
Bouts of movement, locomotor time 1	0.4	0.4	0.6	0.0	-0.4	0.7	0.8	-0.7	-0.7
Total resting periods, locomotor time 1	0.4	0.5	0.8	0.3	-0.4	0.7	0.8	-0.9	-0.9
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.1	-0.3	-0.5	0.6	-0.5	-0.5
Distance moved, locomotor task time 1	0.2	0.3	1.3	0.2	-0.2	1.2	-0.1	0.2	0.3
Vertical activity count, locomotor time 1	0.1	0.2	0.8	0.0	-0.3	0.9	-0.1	0.0	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	0.1	0.1	-0.8	0.0	0.5	0.4
Bouts of movement, locomotor time 2	0.5	0.5	1.8	0.3	-0.6	1.4	0.6	-0.6	-0.5
Total resting periods, locomotor time 2	0.6	0.7	1.9	0.3	-0.6	1.4	0.8	-0.7	-0.6
Rest time, locomotor task time 2	2.0	2.3	3.5	1.4	-1.9	1.0	1.8	-1.5	-1.4
Distance moved, locomotor task time 2	0.3	0.3	1.0	-0.8	0.5	1.0	-0.2	0.2	0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.4	-0.6	0.4	0.2	-0.4	0.5	0.6
Light reinforcement 1	1.0	1.7	2.5	-1.1	1.6	-0.8	-1.3	1.4	1.5
Light reinforcement 2	0.7	1.0	1.3	1.0	-1.0	0.2	1.1	-1.0	-1.1
Bone: marrow area	4.1	8.9	12.9	-3.6	3.3	-3.1	-2.8	2.5	2.4
Bone: maximum diameter	2.3	4.3	6.7	-2.6	2.6	-2.6	-1.8	1.2	1.0
Bone: maximum force	0.1	0.1	0.4	-0.6	0.5	-0.1	-0.0	-0.1	-0.2
Bone: maximum moment	0.0	0.1	0.1	-0.2	0.1	-0.2	0.2	-0.3	-0.4
Mean time between licks in bursts	0.4	0.5	0.9	0.5	-0.7	0.7	0.9	-0.7	-0.6
Mean num. licks in bursts	2.2	2.6	3.6	1.5	-1.4	1.1	1.7	-1.9	-1.9
Cd content in liver	0.4	0.5	1.4	-1.2	0.4	0.4	-0.3	0.6	0.8
Co content in liver	0.6	0.6	1.2	0.8	-0.6	1.1	0.7	-0.8	-0.7
Cu content in liver	0.3	0.4	1.2	1.1	-0.4	0.7	0.3	-0.3	-0.3
Fe content in liver	0.2	0.2	0.5	-0.7	-0.1	0.6	0.3	-0.4	-0.5
K content in liver	0.1	0.1	0.3	-0.2	0.5	0.2	-0.4	-0.0	-0.1
Mg content in liver	0.3	0.3	0.6	-0.8	0.7	0.4	-0.2	-0.4	-0.5
Mn content in liver	0.4	0.5	1.0	0.7	-0.5	0.2	0.7	-0.8	-1.0
Na content in liver	0.6	0.7	0.8	-0.9	0.9	-0.8	-0.9	0.8	0.6
Rb content in liver	0.3	0.4	1.6	-1.3	0.3	0.7	0.0	-0.3	-0.2
Se content in liver	0.5	0.6	1.7	1.3	-0.9	0.5	0.7	-0.3	-0.4
Sr content in liver	0.4	0.3	1.0	-1.0	0.4	-0.4	-0.3	0.5	0.6
Zn content in liver	0.3	0.4	0.5	0.7	0.2	-0.7	-0.7	0.6	0.6
Bone: minimum diameter	0.1	0.2	0.4	-0.3	-0.1	-0.6	0.4	-0.3	-0.4
Time in familiar zone, hab. session 1	0.4	0.4	1.5	-1.2	0.5	-0.3	-0.1	0.3	0.3
Time in novel zone, hab. session 1	0.3	0.3	1.4	1.2	-0.6	0.0	0.1	-0.2	-0.1
Total zone transitions, hab. session 1	0.5	0.8	3.5	0.2	-0.8	1.9	0.5	-0.4	-0.2
Total locomotion distance, hab. session 1	1.1	1.6	7.0	0.6	-1.2	2.6	0.7	-0.6	-0.4
Locomotion velocity, hab. session 1	0.9	1.3	5.5	0.5	-1.1	2.3	0.7	-0.7	-0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.1	-0.1	0.2	0.3	-0.4	-0.5
Time in novel zone, hab. session 2	0.3	0.3	1.0	0.2	0.1	-1.0	-0.3	0.6	0.6
Total zone transitions, hab. session 2	0.9	1.2	6.0	-0.3	-0.2	2.4	0.3	-0.8	-0.6
Total locomotion distance, hab. session 2	0.9	1.2	6.2	-0.4	-0.6	2.5	0.4	-0.4	-0.2
Locomotion velocity, hab. session 2	1.0	1.3	6.1	-0.1	-0.8	2.5	0.7	-0.6	-0.4
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.6	0.4	0.0	-0.2	0.3	0.3
Novelty place preference	0.5	0.5	0.7	-0.9	0.8	-0.5	-0.6	0.7	0.7
Time in novel zone, NPP test	0.7	0.7	1.0	-1.0	0.9	-0.9	-0.6	0.8	0.8
Total zone transitions, NPP test	0.4	0.5	2.3	-0.7	-0.1	1.5	0.3	-0.5	-0.3
Total locomotion distance, NPP test	0.4	0.5	1.9	-0.9	0.0	1.4	-0.2	0.3	0.5
Locomotion velocity, NPP test	0.4	0.6	3.1	-0.6	-0.2	1.8	0.0	0.0	0.2
Intraocular pressure	0.4	0.6	0.9	0.9	-0.4	0.5	0.8	-0.9	-0.8
Delta distance traveled before/after self-admin	1.0	1.1	2.0	-1.4	0.9	-1.1	-0.6	1.1	1.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.4	-1.1	0.6	-1.2	-0.4	0.9	0.9
Parametrial fat weight	0.7	1.4	2.2	-0.1	1.1	-1.2	-1.3	1.5	1.4
Pavlov. Cond. lever latency	3.1	3.9	5.6	2.4	-2.2	1.3	2.0	-1.9	-1.9
Pavlov. Cond. magazine entry latency	0.7	0.9	1.6	-0.8	0.7	-0.5	-1.0	1.2	1.3
Pavlov. Cond. change in total contacts	1.6	1.7	2.1	-1.2	1.3	-1.1	-1.4	1.4	1.4
Pavlov. Cond. index score	2.2	2.7	3.4	-1.6	1.6	-1.0	-1.8	1.9	1.8
Pavlov. Cond. latency score	1.9	2.4	2.9	-1.6	1.6	-0.9	-1.7	1.7	1.7
Pavlov. Cond. lever contacts	2.1	2.5	3.5	-1.9	1.7	-1.0	-1.6	1.6	1.6
Pavlov. Cond. magazine entry number	0.8	1.0	1.7	0.6	-0.8	0.8	1.1	-1.2	-1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.3	-1.1	0.8	0.2	-0.7	0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.5	4.3	-1.8	1.8	-1.2	-2.1	2.1	2.1
Pavlov. Cond. response bias	1.7	2.0	2.7	-1.3	1.4	-1.0	-1.6	1.6	1.6
Pavlov. Cond. lever latency	0.4	0.5	1.4	1.2	-0.8	0.1	-0.1	0.6	0.8
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	1.2	-0.9	0.2	0.6	-0.7	-0.8
Pavlov. Cond. change in total contacts	0.5	0.7	1.9	0.2	-0.1	0.4	0.9	-1.3	-1.4
Pavlov. Cond. index score	0.1	0.2	0.4	-0.2	0.3	-0.3	0.1	-0.5	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.8	-0.3	0.2	-0.3	0.4	-0.7	-0.9
Pavlov. Cond. lever contacts	0.4	0.5	1.6	-1.2	1.0	-0.6	-0.3	-0.2	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.5	0.2	0.2	-0.2	0.4	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.4	0.1	0.5	-0.0	-0.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	-0.1	0.2	-0.2	0.3	-0.7	-0.8
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.5	0.6	-0.3	-0.3	-0.1	-0.2
Time in closed arm before self-admin	1.2	1.4	2.3	-1.0	1.3	-1.5	-0.9	1.1	1.0
Time in closed arm after self-admin	0.1	0.1	0.4	0.6	0.1	-0.5	-0.1	0.2	0.2
Time in open arm before self-admin	0.3	0.4	1.3	-1.1	-0.1	0.4	0.7	-0.4	-0.4
Time in open arm after self-admin	0.3	0.3	0.5	-0.4	-0.5	0.7	0.5	-0.5	-0.6
Bone: periosteal estimation	1.8	3.8	5.5	-2.3	2.2	-2.4	-1.8	1.5	1.3
Bone: periosteal perimeter	0.8	1.3	2.1	-1.2	1.4	-1.5	-1.1	0.9	0.7
Bone: post-yield work	1.9	2.5	4.7	-2.2	1.9	-1.2	-1.5	1.3	1.2
Progressive ratio test 1 active lever presses	0.2	0.2	1.1	0.2	-0.2	-1.1	0.4	0.2	0.1
Progressive ratio test 1 breakpoint	0.5	0.5	2.3	0.2	0.1	-1.5	-0.0	0.6	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	0.7	-0.3	0.3	0.1	-0.2	-0.2
Progressive ratio test 2 active lever presses	0.0	0.1	0.1	-0.1	-0.3	-0.1	0.4	0.1	0.1
Progressive ratio test 2 breakpoint	0.0	0.1	0.2	-0.1	-0.3	-0.0	0.4	-0.0	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.7	0.8	-0.8	-0.3	0.6	-0.2	-0.3
Incentive Sensitization - Responses	0.8	0.8	1.6	0.3	-0.9	1.3	0.9	-0.8	-0.8
Incentive Sensitization - Breakpoint	0.9	0.9	2.1	0.5	-1.0	1.4	0.9	-0.9	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.1	-0.6	-0.2	0.4	0.4
Progressive ratio	0.9	1.1	1.8	-1.3	0.9	-0.7	-0.6	1.2	1.3
Food seeking constrained by brief footshock	0.8	1.0	2.8	-1.4	1.7	-0.7	-0.7	0.4	0.4
Seeking ratio, punishment vs. effort	0.3	0.3	1.0	0.2	0.2	0.4	0.2	-0.8	-1.0
Retroperitoneal fat weight	0.3	1.1	2.1	1.3	-0.8	1.5	0.9	-0.8	-0.6
Reaction time number correct	0.3	0.4	0.6	-0.6	0.7	0.6	-0.8	0.5	0.5
Reaction time mean minus median	0.5	0.6	1.3	1.1	-1.2	0.0	0.9	-0.4	-0.4
Reaction time mean minus median AUC	0.2	0.3	0.9	0.7	-0.9	-0.0	0.6	0.0	0.0
Reaction time num false alarms	0.7	0.9	2.5	1.6	-1.0	1.0	0.7	-0.4	-0.4
Reaction time num false alarms AUC	0.8	1.1	3.3	1.8	-1.0	1.1	0.7	-0.5	-0.6
Reaction time trials correct on left	0.3	0.4	0.6	-0.6	0.7	0.6	-0.8	0.5	0.5
Reaction time trials on left	0.2	0.3	0.6	-0.5	0.6	0.6	-0.8	0.5	0.5
Reaction time mean	0.5	0.7	1.7	0.7	-1.3	0.1	1.1	-0.6	-0.6
Reaction time mean AUC	0.3	0.4	0.9	0.3	-0.9	0.1	0.9	-0.4	-0.5
Median of all reaction times	0.6	0.9	1.9	0.6	-1.4	0.4	1.3	-0.8	-0.8
Reaction time omissions	0.4	0.6	1.2	1.1	-0.9	1.0	0.5	-0.4	-0.3
Reaction time false alarm rate	1.0	1.3	4.0	2.0	-1.3	0.7	1.0	-0.7	-0.7
Reaction time premature initiation rate	0.7	1.0	1.6	-0.4	0.9	-0.6	-1.1	1.2	1.3
Reaction time premature initiations	0.7	1.0	1.5	-0.6	1.1	-0.1	-1.2	1.2	1.2
Std. dev. reaction times	0.7	0.9	1.9	1.3	-1.4	0.4	1.1	-0.5	-0.5
Reaction time trials completed	0.2	0.3	0.6	-0.5	0.6	0.6	-0.8	0.5	0.5
Reaction time trials AUC	0.3	0.4	0.6	-0.6	0.7	0.6	-0.8	0.5	0.5
Run reversals in cocaine runway, females	0.9	0.9	1.5	1.2	-1.0	0.3	1.0	-0.9	-1.0
Run reversals in cocaine runway, males	0.4	0.4	1.0	-1.0	0.9	0.5	-0.3	0.1	0.1
Latency to leave start box in cocaine runway	0.7	0.8	1.2	-0.3	-0.5	1.1	0.9	-1.0	-1.1
Latency to leave start box in cocaine runway, F	0.4	0.5	0.9	-0.3	-0.3	0.9	0.8	-0.7	-0.8
Latency to leave start box in cocaine runway, M	0.6	0.5	0.9	0.1	-0.6	0.9	0.6	-0.9	-0.9
Std. dev. time between licks in bursts	0.5	0.6	1.3	-1.2	0.4	1.0	0.3	-0.6	-0.6
Total sessions with >9 infusions	0.2	0.2	0.9	0.4	-0.2	-0.9	0.3	0.0	-0.2
Short access day 1 total inactive lever presses	1.1	1.2	2.1	0.8	-0.9	0.7	1.5	-1.3	-1.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.0	-0.1	0.4	0.3	-0.5	-0.5
Short access day 1 total infusions	0.4	0.4	1.2	-0.0	-0.2	-1.1	0.1	0.8	0.7
Short access day 10 total infusions	0.8	0.9	3.1	1.2	-0.1	-1.8	-0.4	0.6	0.3
Short access total infusions	0.8	0.9	3.0	1.7	-1.1	-0.8	0.6	-0.0	-0.1
Short access day 1 locomotion	1.5	1.6	2.6	-1.5	1.0	-1.6	-0.7	1.4	1.3
Short access day 10 total locomotion	0.2	0.2	0.4	0.1	-0.0	-0.6	0.6	-0.5	-0.6
Short access total locomotion	0.4	0.4	0.9	0.7	-0.5	-0.9	0.8	-0.2	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.1	-0.4	-0.5	0.1	0.4	0.3
Compulsive drug intake	0.3	0.3	0.9	0.0	-0.9	-0.3	0.6	-0.6	-0.6
One hour access (shock baseline)	0.5	0.5	1.0	-0.3	0.5	-1.0	-0.4	1.0	0.9
Social response proportion	5.9	6.4	9.0	2.3	-2.7	1.6	3.0	-2.7	-2.7
Social responses	0.9	1.1	2.1	0.7	-1.1	0.6	1.5	-1.1	-1.1
Social time	0.2	0.3	0.4	0.5	-0.7	0.4	0.6	-0.6	-0.6
Soleus weight	4.4	13.0	27.8	-5.3	4.7	-2.6	-3.2	2.5	2.4
Bone: stiffness	0.0	0.1	0.3	-0.3	0.1	0.5	-0.0	-0.1	-0.0
Tibialis anterior weight	2.9	9.9	15.3	-3.7	3.9	-3.0	-3.1	2.5	2.3
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.5	-1.2	1.0	-0.7	-1.1	1.0	1.0
Time to tail flick, vehicle, after self-admin	1.6	1.7	3.3	-1.1	1.4	-1.8	-1.1	1.3	1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.2	0.6	-0.3	-0.7	0.4	0.5
Time to tail flick, test, after self-admin	1.1	1.2	1.5	-1.2	1.1	-0.8	-1.1	1.1	1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.0	0.5	-0.7	-0.2	0.4	0.3
Delta time to tail flick, test, before/after SA	0.7	0.6	1.4	-1.2	0.5	-1.0	-0.3	0.7	0.6
Tibia length	0.1	0.4	1.6	0.1	0.1	-1.3	0.6	-0.5	-0.6
Ambulatory time before self-admin	0.3	0.4	0.7	-0.8	0.8	-0.6	-0.4	0.4	0.3
Ambulatory time after self-admin	1.6	1.7	4.0	-2.0	1.4	-1.5	-0.5	1.1	0.9
Bone: tissue strength	1.8	1.7	2.0	1.4	-1.3	1.1	1.4	-1.3	-1.3
Total heroin consumption	1.1	1.3	5.1	-2.3	0.9	-0.1	-0.6	0.7	0.9
Bone: trabecular number	0.3	0.4	0.7	-0.4	0.7	-0.7	-0.9	0.5	0.5
Bone: trabecular spacing	2.4	3.2	4.4	1.5	-2.0	2.1	1.9	-1.7	-1.5
Bone: trabecular thickness	0.2	0.2	0.5	0.7	-0.1	-0.7	0.2	-0.3	-0.4
Bone: trabecular tissue density	0.5	0.7	2.0	1.4	-0.9	-0.2	0.8	-0.4	-0.4
Water consumed over 24 hours	0.3	0.4	1.2	-1.1	0.8	-0.6	-0.1	-0.1	-0.3
Number of responses in last shaping day	7.1	7.4	13.1	-2.0	2.4	-3.6	-2.6	2.8	2.6