Hub : Genes

Fam237a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative polyA NM_001401946.1 0.58 0.09 5.6e-03 0 -0 -0 0 1.3e-01 5.7e-01 7.9e-01 1.9e-01
2 OFC alternative TSS NM_001401946.1 0.35 0.41 2.0e-03 0.02 0 -0.01 0.03 1.0e-01 3.3e-01 8.3e-01 7.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.2-0.40.4
Area under the delay curve0.00.00.00.0-0.1
BMI with tail8.226.527.25.2-5.1
BMI without tail3.77.58.02.7-2.8
Body weight0.41.81.91.4-1.3
Weight adjusted by age0.50.50.6-0.70.8
Bone surface0.50.90.9-0.90.9
Bone volume0.91.51.5-1.21.2
Breakpoint value in progressive ratio session1.21.41.4-1.21.1
Number of licking bursts0.40.40.40.7-0.7
Context. condit. distance diff. score1.61.91.91.4-1.4
Locomotion velocity, session 11.71.82.1-1.41.3
Locomotion distance, session 10.30.40.6-0.80.5
Locomotion velocity, session 20.30.30.4-0.60.6
Locomotion distance, session 20.00.00.0-0.10.1
Locomotion velocity, session 30.70.80.80.9-0.9
Locomotion distance, session 31.31.41.5-1.21.2
Stereotopy head waving bouts, day 31.92.22.31.5-1.5
Stereotopy head waving duration, day 32.12.62.61.6-1.6
Locomotion velocity, session 70.00.00.00.2-0.2
Locomotion distance, session 70.30.40.5-0.60.7
Stereotopy head waving bouts, day 70.50.60.60.7-0.7
Stereotopy head waving duration, day 72.22.62.71.6-1.6
Locomotion velocity, session 80.10.10.10.2-0.3
Locomotion distance, session 80.30.50.50.7-0.7
Degree of sensitization distance0.30.30.30.5-0.5
Degree of sensitization stereotypy0.80.90.90.9-0.9
Conditioned locomotion1.41.61.6-1.31.3
Cocaine response after cond. corrected1.51.71.7-1.31.3
Cocaine response after cond. not corrected1.51.71.7-1.31.3
Cocaine response before conditioning0.10.10.10.3-0.3
Saline control response0.40.60.60.8-0.8
Bone: connectivity density0.30.40.40.7-0.7
Bone: cortical apparent density1.72.32.31.5-1.5
Bone: cortical area0.71.11.1-1.11.1
Bone: cortical porosity6.36.96.9-2.62.6
Bone: cortical porosity7.48.08.0-2.82.8
Bone: cortical thickness0.20.30.3-0.50.5
Bone: cortical thickness2.52.92.9-1.71.7
Bone: cortical tissue density2.12.72.71.7-1.7
Condit. Reinf. active minus inactive responses0.91.01.1-0.91.0
Condit. Reinf. active-inactive response ratio0.00.00.0-0.00.1
Condit. Reinf. active responses1.92.42.5-1.51.6
Condit. Reinf. inactive responses1.92.22.2-1.51.5
Incentive salience index mean1.51.81.9-1.31.4
Condit. Reinf. lever presses1.82.42.5-1.51.6
Condit. Reinf. active minus inactive responses9.211.411.4-3.43.4
Condit. Reinf. active-inactive response ratio7.37.77.7-2.82.8
Condit. Reinf. active responses6.59.09.0-3.03.0
Condit. Reinf. inactive responses0.50.60.6-0.80.8
Condit. Reinf. lever presses1.31.81.8-1.31.3
Condit. Reinf. lever reinforcers received6.69.39.3-3.03.0
Conditioned reinforcement - actives0.40.40.50.7-0.5
Conditioned reinforcement - inactives2.83.13.4-1.71.9
Conditioned locomotion2.63.14.12.0-1.5
Patch foraging indifference point 0 sec1.22.02.01.4-1.4
Patch foraging indifference point AUC1.82.02.0-1.41.4
Delay disc. indifference point, 0s delay1.11.21.21.1-1.1
Delay disc. indifference point, 16s delay0.00.00.0-0.20.2
Delay disc. indifference point, 2s delay1.21.41.41.2-1.2
Delay disc. indifference point, 24s delay0.10.10.10.3-0.4
Delay disc. indifference point, 4s delay0.70.80.80.9-0.9
Delay disc. indifference point, 8s delay0.10.10.1-0.30.2
Indifference point function ln k3.14.34.32.1-2.1
Indifference point function log k3.14.34.32.1-2.1
Patch foraging total patch changes 0 sec1.11.91.91.4-1.4
Patch foraging total patch changes 12 sec0.20.30.3-0.50.5
Patch foraging total patch changes 18 sec0.30.40.40.6-0.6
Patch foraging total patch changes 24 sec0.10.10.1-0.40.3
Patch foraging total patch changes 6 sec0.50.70.80.9-0.9
Patch foraging time to switch 0 sec0.00.00.00.2-0.2
Patch foraging water rate 0 sec0.10.10.10.4-0.3
Patch foraging water rate 12 sec1.11.71.71.3-1.3
Patch foraging water rate 18 sec0.10.10.1-0.30.3
Patch foraging water rate 24 sec0.50.60.70.8-0.8
Patch foraging water rate 6 sec2.43.43.51.8-1.9
Seeking ratio, delayed vs. immediate footshock0.40.50.5-0.70.7
Distance traveled before self-admin5.86.26.7-2.42.6
Distance traveled after self-admin0.10.10.1-0.40.3
Extensor digitorum longus weight1.56.16.22.5-2.4
Bone: elastic displacement0.10.10.10.3-0.3
Bone: elastic work0.30.40.4-0.60.6
Bone: endosteal estimation1.63.43.4-1.91.9
Bone: endosteal perimeter0.20.50.5-0.70.7
Epididymis fat weight0.00.10.10.3-0.2
Delta time in closed arm before/after self-admin0.50.50.80.9-0.5
Delta time in open arm before/after self-admin4.34.24.3-2.02.1
Diff in mean of infusions in LGA sessions0.40.50.60.8-0.6
Delay discount exponential model param0.00.00.00.00.1
Extinction: sum of active levers before priming0.00.00.0-0.10.2
Active lever presses in extinction session 60.60.50.7-0.80.6
Bone: final force1.01.61.6-1.31.3
Bone: final moment0.50.80.8-0.90.9
Food consumed during 24 hour testing period0.80.90.9-1.01.0
Glucose1.01.51.51.2-1.2
Heart weight0.00.00.00.2-0.2
Delay discount hyperbolic model param0.10.10.1-0.20.3
Intermittent access intake day 1-15 change0.10.10.10.3-0.4
Intermittent access intake escalation0.10.10.10.2-0.3
Intermittent access intake escalation 20.00.00.0-0.1-0.0
Intermitt. access day 1 inactive lever presses0.00.00.1-0.30.1
Intermitt. access day 15 inactive lever presses0.91.01.2-0.81.1
Intermitt. access escalation Index0.20.20.20.5-0.3
Intermittent access day 1 total infusions0.00.00.0-0.00.1
Intermittent access day 15 total infusions0.30.30.30.5-0.6
Intermittent access terminal intake (last 3 days)0.80.91.00.9-1.0
Intermittent access total infusions0.00.00.0-0.0-0.1
Intermittent access day 1 locomotion0.10.10.2-0.20.4
Intermittent access day 15 total locomotion0.00.00.0-0.20.2
Intermittent access total locomotion0.00.00.00.20.1
Intermittent access standard deviation0.10.20.2-0.50.3
Left kidney weight0.00.00.10.3-0.1
Right kidney weight0.10.30.30.6-0.5
Cocaine induced anxiety1.61.92.81.7-1.0
Post-drug Anxiety1.51.72.41.5-1.0
Baseline Anxiety0.70.81.1-1.00.7
Tail length5.015.216.4-4.03.7
Length with tail4.817.717.7-4.24.2
Length without tail0.92.02.4-1.31.6
Times rat made contact with spout0.80.90.9-1.01.0
Lifetime Intake0.30.30.30.5-0.6
Liver weight, left2.13.33.3-1.81.8
Liver weight, right1.11.91.9-1.41.4
Locomotor activity0.00.10.10.3-0.3
Locomotor testing distance0.40.70.70.9-0.8
Locomotor testing rearing0.20.30.30.6-0.6
Locomotion in novel chamber0.50.60.70.9-0.7
Locomotion in novel chamber post-restriction0.00.00.0-0.10.0
Fecal boli incidents, locomotor time 11.21.31.3-1.11.1
Change in fecal boli incidents, locomotor task0.20.20.2-0.40.4
Time >=10cm from walls, locomotor time 13.43.43.4-1.81.9
Bouts of movement, locomotor time 11.82.02.0-1.41.4
Total resting periods, locomotor time 11.31.41.4-1.21.2
Rest time, locomotor task time 11.82.02.0-1.41.4
Distance moved, locomotor task time 10.30.30.30.6-0.6
Vertical activity count, locomotor time 10.90.91.01.0-1.0
Time >=10cm from walls, locomotor time 20.50.50.6-0.80.7
Bouts of movement, locomotor time 20.70.80.80.9-0.9
Total resting periods, locomotor time 20.10.20.20.4-0.4
Rest time, locomotor task time 22.32.62.6-1.61.6
Distance moved, locomotor task time 20.80.90.90.9-1.0
Vertical activity count, locomotor time 23.94.34.32.1-2.1
Light reinforcement 11.52.82.81.7-1.7
Light reinforcement 20.60.70.8-0.90.9
Bone: marrow area1.53.43.4-1.81.8
Bone: maximum diameter0.91.61.6-1.31.3
Bone: maximum force0.40.70.7-0.80.8
Bone: maximum moment0.10.20.2-0.40.4
Mean time between licks in bursts0.50.70.70.8-0.8
Mean num. licks in bursts0.70.80.8-0.90.9
Cd content in liver0.50.50.70.8-0.6
Co content in liver0.20.30.30.6-0.5
Cu content in liver0.00.00.00.1-0.1
Fe content in liver0.00.00.0-0.10.1
K content in liver0.00.00.00.0-0.1
Mg content in liver0.50.50.50.7-0.7
Mn content in liver2.52.82.91.6-1.7
Na content in liver1.31.41.4-1.21.2
Rb content in liver0.00.00.0-0.0-0.1
Se content in liver1.01.21.21.1-1.1
Sr content in liver0.20.20.2-0.50.5
Zn content in liver0.40.40.40.6-0.6
Bone: minimum diameter1.22.22.2-1.51.5
Time in familiar zone, hab. session 12.52.32.51.6-1.5
Time in novel zone, hab. session 16.76.56.8-2.62.5
Total zone transitions, hab. session 10.60.90.9-0.90.9
Total locomotion distance, hab. session 11.92.72.8-1.71.6
Locomotion velocity, hab. session 11.52.12.2-1.51.4
Time in familiar zone, hab. session 20.10.10.20.4-0.2
Time in novel zone, hab. session 20.00.00.0-0.0-0.1
Total zone transitions, hab. session 20.00.00.0-0.2-0.0
Total locomotion distance, hab. session 20.00.00.1-0.30.1
Locomotion velocity, hab. session 20.00.00.1-0.30.1
Novel to familiar place preference ratio1.41.51.5-1.21.2
Novelty place preference2.12.12.2-1.51.4
Time in novel zone, NPP test2.32.32.4-1.51.5
Total zone transitions, NPP test0.20.30.3-0.50.6
Total locomotion distance, NPP test0.60.80.8-0.90.9
Locomotion velocity, NPP test0.30.40.4-0.60.6
Intraocular pressure3.14.34.42.0-2.1
Delta distance traveled before/after self-admin3.03.23.91.6-2.0
Delta ambulatory time before/after self-admin2.83.13.71.5-1.9
Parametrial fat weight0.20.40.4-0.50.6
Pavlov. Cond. lever latency0.10.10.10.3-0.3
Pavlov. Cond. magazine entry latency0.40.50.5-0.70.7
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1
Pavlov. Cond. index score0.50.60.7-0.80.8
Pavlov. Cond. latency score0.40.50.6-0.70.7
Pavlov. Cond. lever contacts0.30.40.4-0.60.6
Pavlov. Cond. magazine entry number0.20.20.20.4-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.60.70.8-0.80.9
Pavlov. Cond. response bias0.60.70.8-0.80.9
Pavlov. Cond. lever latency1.31.81.81.3-1.3
Pavlov. Cond. magazine entry latency0.40.40.4-0.70.7
Pavlov. Cond. change in total contacts1.82.52.5-1.61.6
Pavlov. Cond. index score2.22.92.9-1.71.7
Pavlov. Cond. latency score2.12.62.6-1.61.6
Pavlov. Cond. lever contacts2.43.23.2-1.81.8
Pavlov. Cond. magazine entry number1.21.51.51.2-1.2
Pavlov. Cond. intertrial magazine entries2.22.92.91.7-1.7
Pavlov. Cond. lever-magazine prob. diff.2.02.62.6-1.61.6
Pavlov. Cond. response bias2.43.33.3-1.81.8
Time in closed arm before self-admin1.82.12.3-1.41.5
Time in closed arm after self-admin0.10.10.1-0.10.4
Time in open arm before self-admin3.13.33.41.8-1.8
Time in open arm after self-admin1.41.61.7-1.21.3
Bone: periosteal estimation1.63.33.3-1.81.8
Bone: periosteal perimeter1.11.91.9-1.41.4
Bone: post-yield work0.10.20.20.4-0.4
Progressive ratio test 1 active lever presses0.00.10.1-0.30.2
Progressive ratio test 1 breakpoint0.10.10.1-0.40.3
Progressive ratio test 1 inactive lever presses1.01.11.21.0-1.1
Progressive ratio test 2 active lever presses0.00.00.00.2-0.0
Progressive ratio test 2 breakpoint0.00.00.00.00.2
Progressive ratio test 2 inactive lever presses0.00.00.00.10.2
Incentive Sensitization - Responses0.50.50.7-0.60.8
Incentive Sensitization - Breakpoint0.40.40.5-0.50.7
Sum of active levers in priming session hrs 5-61.61.61.6-1.21.3
Progressive ratio0.10.10.20.5-0.3
Food seeking constrained by brief footshock1.51.92.11.4-1.3
Seeking ratio, punishment vs. effort0.20.30.30.5-0.5
Retroperitoneal fat weight0.82.72.91.7-1.6
Reaction time number correct0.60.90.91.0-0.9
Reaction time mean minus median0.00.00.0-0.00.0
Reaction time mean minus median AUC0.00.00.0-0.20.2
Reaction time num false alarms4.15.65.62.4-2.4
Reaction time num false alarms AUC3.85.25.32.3-2.3
Reaction time trials correct on left0.60.90.91.0-0.9
Reaction time trials on left0.60.90.91.0-0.9
Reaction time mean3.54.95.0-2.22.2
Reaction time mean AUC2.63.63.6-1.91.9
Median of all reaction times5.27.17.1-2.72.7
Reaction time omissions0.00.10.10.2-0.2
Reaction time false alarm rate1.72.42.41.5-1.6
Reaction time premature initiation rate0.30.40.4-0.60.6
Reaction time premature initiations0.00.00.0-0.00.0
Std. dev. reaction times0.50.70.7-0.80.8
Reaction time trials completed0.60.90.91.0-0.9
Reaction time trials AUC0.40.60.60.8-0.8
Run reversals in cocaine runway, females1.21.21.21.1-1.1
Run reversals in cocaine runway, males0.00.00.0-0.10.1
Latency to leave start box in cocaine runway3.94.24.32.0-2.1
Latency to leave start box in cocaine runway, F2.93.23.21.8-1.8
Latency to leave start box in cocaine runway, M0.10.10.10.2-0.3
Std. dev. time between licks in bursts3.23.93.92.0-2.0
Total sessions with >9 infusions0.40.40.60.5-0.7
Short access day 1 total inactive lever presses0.10.10.1-0.00.3
Short access day 10 total inactive lever presses0.50.60.8-0.90.7
Short access day 1 total infusions0.40.40.50.6-0.7
Short access day 10 total infusions0.10.10.1-0.40.2
Short access total infusions0.80.90.91.0-0.9
Short access day 1 locomotion1.01.11.2-1.11.0
Short access day 10 total locomotion0.60.71.0-0.51.0
Short access total locomotion0.10.10.2-0.10.4
One hour access (0.3 mA shock)0.30.30.4-0.70.5
Compulsive drug intake0.30.30.4-0.50.6
One hour access (shock baseline)0.00.00.0-0.0-0.2
Social response proportion0.60.60.6-0.80.8
Social responses0.60.80.8-0.90.9
Social time0.30.40.4-0.60.6
Soleus weight0.00.10.2-0.30.4
Bone: stiffness0.40.60.6-0.80.8
Tibialis anterior weight0.20.80.91.0-0.8
Time to tail flick, vehicle, before self-admin0.10.10.10.2-0.2
Time to tail flick, vehicle, after self-admin0.10.10.1-0.20.3
Time to tail flick, test, before self-admin0.00.00.00.10.2
Time to tail flick, test, after self-admin1.41.41.71.3-1.0
Delta time to tail flick, vehicle, before/after SA0.10.10.10.4-0.3
Delta time to tail flick, test, before/after SA0.20.20.20.5-0.4
Tibia length1.64.44.4-2.12.1
Ambulatory time before self-admin3.33.43.9-1.72.0
Ambulatory time after self-admin0.30.30.30.6-0.5
Bone: tissue strength1.01.01.01.0-1.0
Total heroin consumption0.50.60.6-0.80.8
Bone: trabecular number0.10.10.10.3-0.3
Bone: trabecular spacing0.10.20.2-0.40.4
Bone: trabecular thickness0.30.40.4-0.60.6
Bone: trabecular tissue density0.60.80.8-0.90.9
Water consumed over 24 hours0.10.10.10.4-0.4
Number of responses in last shaping day0.00.00.0-0.20.1