Fam174c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Fam174c	0.04	0.03	1.0e-03	0.03	0.02	0.02	0.02	1.7e-04	1.9e-03	2.0e-03	1.5e-03
2	Liver	intron excision ratio	chr7_9532820_9533319	0.08	0.05	1.4e-08	0.06	0.06	0.05	0.06	2.3e-07	4.8e-07	1.2e-06	5.3e-07
3	Liver	intron excision ratio	chr7_9532820_9533901	0.07	0.05	6.2e-08	0.04	0.05	0.04	0.04	1.6e-05	4.3e-06	1.2e-05	8.0e-06
4	Liver	gene expression	Fam174c	0.02	0.02	7.3e-03	0.02	0.01	0.01	0.01	4.3e-03	1.9e-02	2.3e-02	1.3e-02
5	Brain	gene expression	Fam174c	0.04	0.03	6.0e-03	0	0.01	0.01	0	1.4e-01	4.4e-02	3.7e-02	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.2	2.0	6.9	-0.9	0.9	0.4	1.1	-2.6
Area under the delay curve	1.9	2.0	2.9	1.7	-1.7	-1.6	-1.2	0.0
BMI with tail	5.8	18.7	23.9	4.7	-4.7	-4.9	-4.8	1.3
BMI without tail	3.0	6.3	7.2	2.7	-2.7	-2.7	-2.7	1.7
Body weight	1.1	4.5	5.9	2.3	-2.3	-2.4	-2.3	0.7
Weight adjusted by age	1.3	1.5	2.1	1.3	-1.3	-1.0	-0.9	1.4
Bone surface	3.0	5.2	13.5	-1.8	1.9	1.2	2.1	-3.7
Bone volume	2.9	5.0	13.3	-1.7	1.7	1.1	2.1	-3.6
Breakpoint value in progressive ratio session	3.5	3.8	5.6	-2.2	2.1	2.4	2.1	0.4
Number of licking bursts	0.8	0.9	2.3	0.9	-0.8	-0.5	-0.6	1.5
Context. condit. distance diff. score	0.2	0.2	0.4	0.3	-0.3	-0.5	-0.6	0.4
Locomotion velocity, session 1	1.4	1.5	2.3	-1.2	1.2	1.0	1.2	-1.5
Locomotion distance, session 1	2.6	3.3	7.0	-1.9	1.9	1.1	0.9	-2.6
Locomotion velocity, session 2	7.4	8.6	11.5	-3.4	3.4	2.8	2.5	-2.5
Locomotion distance, session 2	4.3	6.0	8.3	-2.5	2.5	2.1	2.0	-2.9
Locomotion velocity, session 3	4.9	5.7	7.5	-2.7	2.7	2.7	2.5	0.1
Locomotion distance, session 3	0.1	0.1	0.3	-0.0	0.1	-0.1	-0.1	0.5
Stereotopy head waving bouts, day 3	5.6	6.6	8.8	-3.0	3.0	2.8	2.5	-1.1
Stereotopy head waving duration, day 3	5.6	6.6	8.7	-2.9	2.9	2.9	2.6	-0.7
Locomotion velocity, session 7	0.7	0.7	1.2	-1.0	1.0	0.6	1.1	0.2
Locomotion distance, session 7	0.6	0.7	1.7	0.7	-0.7	-0.7	-0.6	1.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.7	-0.9	0.9	0.5	0.5	-1.3
Stereotopy head waving duration, day 7	1.2	1.4	2.5	-1.2	1.2	0.8	1.0	-1.6
Locomotion velocity, session 8	2.7	3.2	4.4	-2.0	2.0	1.3	1.4	-2.1
Locomotion distance, session 8	0.7	1.0	1.6	-1.3	1.3	0.8	0.5	-1.1
Degree of sensitization distance	0.2	0.2	0.4	0.5	-0.5	-0.6	-0.5	0.1
Degree of sensitization stereotypy	0.8	0.9	1.5	0.9	-0.9	-1.2	-0.9	-0.8
Conditioned locomotion	2.5	2.9	3.3	1.7	-1.7	-1.7	-1.8	1.6
Cocaine response after cond. corrected	8.3	9.3	11.7	3.4	-3.4	-3.0	-2.9	2.4
Cocaine response after cond. not corrected	8.7	9.6	11.7	3.4	-3.4	-3.1	-3.0	2.5
Cocaine response before conditioning	0.7	0.8	1.2	-1.1	1.1	0.9	0.9	-0.4
Saline control response	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.4	0.3
Bone: connectivity density	0.6	0.9	4.2	-0.3	0.4	-0.1	0.4	-2.1
Bone: cortical apparent density	1.0	1.3	2.2	1.5	-1.5	-1.1	-1.0	0.3
Bone: cortical area	0.2	0.3	0.9	0.4	-0.4	-0.7	-0.1	-0.9
Bone: cortical porosity	1.0	1.1	1.2	-1.1	1.1	0.9	1.1	-1.0
Bone: cortical porosity	0.8	0.9	2.0	-0.9	0.9	0.4	0.7	-1.4
Bone: cortical thickness	0.6	1.0	1.6	1.0	-1.0	-1.3	-0.9	-0.5
Bone: cortical thickness	0.5	0.6	1.7	0.8	-0.8	-0.4	-0.4	1.3
Bone: cortical tissue density	0.8	1.0	1.8	1.3	-1.3	-0.9	-0.8	0.3
Condit. Reinf. active minus inactive responses	3.9	4.4	5.9	-2.4	2.4	2.4	2.1	-0.3
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.0	-1.0	1.0	1.4	1.2	0.7
Condit. Reinf. active responses	5.1	6.2	8.6	-2.9	2.9	2.6	2.3	-1.5
Condit. Reinf. inactive responses	2.8	3.3	4.3	-2.1	2.0	1.5	1.4	-2.0
Incentive salience index mean	3.4	4.1	5.9	-2.4	2.4	2.1	1.8	-1.2
Condit. Reinf. lever presses	1.7	2.3	6.2	-1.4	1.4	0.7	0.8	-2.5
Condit. Reinf. active minus inactive responses	0.9	1.1	1.6	-0.8	0.8	1.2	1.3	1.0
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.9	0.8	-0.8	-0.2	-0.4	1.4
Condit. Reinf. active responses	1.0	1.4	2.8	-1.0	1.0	1.4	1.7	0.5
Condit. Reinf. inactive responses	0.9	1.1	2.2	-1.0	1.0	1.0	1.5	0.0
Condit. Reinf. lever presses	1.1	1.5	2.2	-1.2	1.2	1.5	1.4	0.7
Condit. Reinf. lever reinforcers received	0.6	0.9	1.7	-0.7	0.6	1.0	1.3	0.9
Conditioned reinforcement - actives	2.0	2.0	2.7	-1.6	1.6	1.5	1.5	-0.3
Conditioned reinforcement - inactives	0.6	0.7	1.1	0.8	-0.8	-0.8	-1.0	0.6
Conditioned locomotion	5.7	6.9	9.0	-3.0	3.0	3.0	2.8	-0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.2	-0.4
Patch foraging indifference point AUC	0.4	0.5	0.8	-0.8	0.7	0.9	0.7	0.2
Delay disc. indifference point, 0s delay	3.5	3.8	5.1	1.7	-1.7	-2.2	-2.0	-2.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.3	0.6	-0.5	-0.3	-0.2	0.0
Delay disc. indifference point, 2s delay	3.4	3.8	5.8	2.1	-2.1	-2.4	-2.1	-0.6
Delay disc. indifference point, 24s delay	1.1	1.1	1.7	1.3	-1.3	-1.1	-0.8	0.5
Delay disc. indifference point, 4s delay	0.5	0.6	0.8	0.8	-0.8	-0.9	-0.6	-0.5
Delay disc. indifference point, 8s delay	1.7	1.8	2.5	1.6	-1.6	-1.4	-1.2	0.8
Indifference point function ln k	0.3	0.4	0.6	0.8	-0.8	-0.7	-0.4	0.4
Indifference point function log k	0.3	0.4	0.6	0.8	-0.8	-0.7	-0.4	0.4
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.3	-0.3	-0.4	-0.2	-0.1
Patch foraging total patch changes 12 sec	0.6	0.8	1.3	0.8	-0.8	-0.8	-1.1	0.9
Patch foraging total patch changes 18 sec	0.8	1.1	1.5	-1.2	1.1	1.2	1.1	-0.1
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	-0.2	0.2	0.3	0.3	-0.2
Patch foraging total patch changes 6 sec	0.2	0.2	0.4	-0.5	0.4	0.6	0.7	-0.2
Patch foraging time to switch 0 sec	0.6	0.9	3.5	-0.1	0.1	-0.6	-0.8	-1.9
Patch foraging water rate 0 sec	1.0	1.7	5.1	1.1	-1.1	-0.7	-0.6	2.3
Patch foraging water rate 12 sec	3.0	4.6	5.7	2.4	-2.4	-1.9	-1.8	2.3
Patch foraging water rate 18 sec	2.4	3.2	10.6	1.4	-1.4	-0.7	-1.0	3.3
Patch foraging water rate 24 sec	3.4	4.7	10.0	2.0	-2.1	-1.4	-1.7	3.2
Patch foraging water rate 6 sec	0.7	1.1	4.4	0.7	-0.7	-0.1	-0.2	2.1
Seeking ratio, delayed vs. immediate footshock	3.8	4.4	6.2	-2.2	2.2	2.4	2.5	-0.8
Distance traveled before self-admin	0.3	0.3	0.5	0.6	-0.7	-0.6	-0.4	-0.4
Distance traveled after self-admin	0.6	0.7	0.9	-0.9	0.8	0.9	0.9	-0.5
Extensor digitorum longus weight	4.6	18.1	22.6	4.5	-4.5	-4.8	-4.7	2.1
Bone: elastic displacement	0.1	0.1	0.4	-0.2	0.2	0.5	0.7	-0.2
Bone: elastic work	0.2	0.3	0.5	0.7	-0.7	-0.6	-0.0	-0.1
Bone: endosteal estimation	0.1	0.1	0.3	0.4	-0.4	-0.5	-0.3	-0.0
Bone: endosteal perimeter	0.5	1.1	1.4	-1.1	1.1	0.9	1.2	-0.9
Epididymis fat weight	0.1	0.3	0.6	-0.7	0.7	0.8	0.1	0.3
Delta time in closed arm before/after self-admin	3.6	3.5	6.0	1.8	-1.9	-1.4	-1.7	2.5
Delta time in open arm before/after self-admin	0.6	0.6	0.9	0.8	-0.8	-0.9	-0.9	-0.4
Diff in mean of infusions in LGA sessions	1.6	1.8	2.5	-1.6	1.5	1.6	1.4	-0.2
Delay discount exponential model param	1.8	1.9	2.8	-1.7	1.6	1.6	1.2	-0.1
Extinction: sum of active levers before priming	0.6	0.6	0.8	-0.8	0.8	0.9	0.5	0.8
Active lever presses in extinction session 6	2.2	2.2	3.0	-1.6	1.5	1.7	1.7	-0.6
Bone: final force	0.6	1.0	2.0	1.1	-1.1	-1.4	-0.8	-0.4
Bone: final moment	0.5	0.8	1.5	1.0	-1.0	-1.2	-0.6	-0.3
Food consumed during 24 hour testing period	1.0	1.2	2.0	1.4	-1.4	-1.0	-0.8	0.7
Glucose	1.5	2.3	3.4	1.8	-1.8	-1.6	-1.5	0.4
Heart weight	0.1	0.1	0.5	0.0	-0.0	0.4	0.2	0.7
Delay discount hyperbolic model param	2.3	2.5	3.5	-1.9	1.8	1.9	1.4	-0.1
Intermittent access intake day 1-15 change	4.7	4.6	6.2	-2.3	2.4	2.5	2.4	0.1
Intermittent access intake escalation	3.3	3.3	4.7	-1.9	1.9	2.2	1.9	0.9
Intermittent access intake escalation 2	4.2	4.1	6.0	-2.1	2.2	2.4	2.1	1.0
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.7	0.1	-0.2	0.0	0.0	0.8
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.4	-0.6	0.6	0.7	0.5	0.2
Intermitt. access escalation Index	0.2	0.2	0.9	0.0	-0.0	-0.2	0.3	-0.9
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.3
Intermittent access day 15 total infusions	1.1	1.2	1.8	-1.1	1.2	1.3	1.2	0.4
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.1	-1.0	1.1	1.0	1.0	-0.1
Intermittent access total infusions	0.1	0.1	0.2	-0.3	0.4	0.4	0.3	0.1
Intermittent access day 1 locomotion	0.2	0.2	0.4	-0.5	0.6	0.6	0.5	0.1
Intermittent access day 15 total locomotion	2.6	2.8	4.1	-1.9	1.9	2.0	1.6	-0.1
Intermittent access total locomotion	0.8	0.9	1.3	-1.1	1.1	1.1	1.0	-0.3
Intermittent access standard deviation	1.4	1.5	2.1	-1.3	1.3	1.5	1.3	0.6
Left kidney weight	0.1	0.2	0.4	-0.3	0.3	0.3	0.6	-0.6
Right kidney weight	1.0	2.9	4.2	-1.8	1.8	2.0	2.1	-0.2
Cocaine induced anxiety	1.4	1.6	2.3	-1.2	1.3	1.1	1.2	-1.5
Post-drug Anxiety	1.3	1.5	2.2	-1.3	1.3	1.0	1.0	-1.5
Baseline Anxiety	0.2	0.2	0.9	-0.0	-0.0	0.2	-0.1	1.0
Tail length	2.1	6.4	8.7	-2.8	2.8	3.0	2.7	0.3
Length with tail	1.7	6.3	8.3	-2.7	2.7	2.7	2.9	-0.8
Length without tail	0.4	1.0	1.9	-1.0	0.9	0.6	0.9	-1.4
Times rat made contact with spout	0.9	1.0	1.5	1.1	-1.1	-0.7	-0.8	1.2
Lifetime Intake	0.0	0.1	0.1	-0.2	0.3	0.3	0.2	-0.0
Liver weight, left	2.1	3.4	5.5	1.9	-1.9	-2.0	-2.3	0.7
Liver weight, right	1.0	1.6	3.1	1.2	-1.2	-1.5	-1.8	-0.1
Locomotor activity	4.1	6.5	8.5	-2.7	2.6	2.5	2.9	-1.8
Locomotor testing distance	2.1	3.5	4.9	-2.0	2.0	1.9	2.2	-1.2
Locomotor testing rearing	0.1	0.2	0.5	0.3	-0.3	-0.1	-0.0	0.7
Locomotion in novel chamber	0.1	0.1	0.6	0.2	-0.1	0.2	0.1	0.8
Locomotion in novel chamber post-restriction	0.5	0.6	0.9	-0.8	0.8	0.9	0.9	0.5
Fecal boli incidents, locomotor time 1	1.8	1.9	3.1	1.4	-1.4	-1.5	-1.8	0.6
Change in fecal boli incidents, locomotor task	0.4	0.4	1.0	-0.4	0.4	0.3	1.0	-0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.4	0.5	-0.5	-0.6	-0.1	-1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	0.1
Rest time, locomotor task time 1	0.5	0.6	1.0	-1.0	1.0	0.7	0.5	-0.4
Distance moved, locomotor task time 1	0.4	0.4	1.2	0.6	-0.6	-0.6	-0.1	-1.1
Vertical activity count, locomotor time 1	0.8	0.9	1.5	1.2	-1.2	-0.8	-0.3	0.8
Time >=10cm from walls, locomotor time 2	1.9	2.0	2.7	1.6	-1.6	-1.5	-1.3	0.7
Bouts of movement, locomotor time 2	1.3	1.3	1.9	-1.1	1.2	1.1	1.0	-1.4
Total resting periods, locomotor time 2	1.3	1.4	2.1	-1.1	1.2	1.0	1.0	-1.4
Rest time, locomotor task time 2	0.9	1.0	1.2	-1.0	1.0	1.0	1.1	-0.9
Distance moved, locomotor task time 2	0.8	1.0	1.4	0.9	-1.0	-1.1	-1.2	0.7
Vertical activity count, locomotor time 2	1.5	1.6	2.0	1.2	-1.3	-1.2	-1.3	1.4
Light reinforcement 1	6.0	11.0	13.9	-3.7	3.7	3.7	3.4	-1.4
Light reinforcement 2	2.4	3.2	4.2	-2.0	2.1	1.9	1.8	-1.0
Bone: marrow area	0.1	0.1	0.3	0.4	-0.4	-0.5	-0.3	-0.0
Bone: maximum diameter	1.3	2.4	3.0	-1.6	1.6	1.4	1.7	-1.4
Bone: maximum force	0.7	1.2	2.3	1.2	-1.3	-1.5	-0.9	-0.0
Bone: maximum moment	0.6	1.0	1.8	1.2	-1.2	-1.3	-0.8	-0.0
Mean time between licks in bursts	2.8	3.9	5.4	-2.2	2.2	2.3	2.1	0.3
Mean num. licks in bursts	0.0	0.0	0.1	0.1	-0.1	-0.0	0.0	-0.4
Cd content in liver	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.3	-0.3
Co content in liver	0.4	0.5	0.8	-0.9	0.9	0.7	0.6	0.2
Cu content in liver	0.3	0.4	1.6	-0.3	0.3	-0.1	0.2	-1.3
Fe content in liver	0.2	0.2	0.3	-0.6	0.6	0.1	-0.1	0.5
K content in liver	0.9	0.9	2.0	-1.1	1.1	0.3	0.4	-1.4
Mg content in liver	0.8	0.8	2.2	-0.9	0.9	0.2	0.5	-1.5
Mn content in liver	4.1	4.6	6.0	-2.3	2.3	1.5	2.0	-2.5
Na content in liver	0.5	0.5	1.7	-0.4	0.4	-0.6	-0.5	-1.3
Rb content in liver	0.3	0.4	1.9	-0.1	0.1	-0.3	-0.0	-1.4
Se content in liver	0.5	0.6	1.1	-1.1	1.1	0.7	0.5	-0.4
Sr content in liver	0.4	0.4	1.4	0.4	-0.4	-0.2	-0.4	1.2
Zn content in liver	0.8	0.9	3.2	-0.3	0.3	0.9	0.5	1.8
Bone: minimum diameter	0.1	0.2	0.3	-0.4	0.4	0.0	0.4	-0.5
Time in familiar zone, hab. session 1	1.2	1.1	1.8	-1.0	1.0	1.3	1.2	0.7
Time in novel zone, hab. session 1	0.5	0.5	1.1	0.6	-0.6	-0.8	-0.4	-1.1
Total zone transitions, hab. session 1	2.5	3.4	4.1	-2.0	2.0	1.6	1.6	-2.0
Total locomotion distance, hab. session 1	3.9	5.5	7.3	-2.6	2.6	1.8	2.0	-2.7
Locomotion velocity, hab. session 1	4.2	6.0	7.7	-2.8	2.8	2.1	2.0	-2.5
Time in familiar zone, hab. session 2	3.1	3.2	5.8	-1.6	1.7	2.4	2.0	0.9
Time in novel zone, hab. session 2	2.8	2.8	4.2	1.8	-1.9	-2.1	-1.6	-0.9
Total zone transitions, hab. session 2	1.4	1.8	7.5	-0.8	0.8	0.4	0.3	-2.7
Total locomotion distance, hab. session 2	2.5	3.4	4.9	-1.9	1.9	1.7	1.4	-2.2
Locomotion velocity, hab. session 2	3.1	4.1	7.2	-2.0	2.0	1.8	1.5	-2.7
Novel to familiar place preference ratio	2.1	2.2	3.4	1.4	-1.4	-1.8	-1.4	-1.3
Novelty place preference	1.3	1.3	1.8	1.0	-1.0	-1.4	-1.0	-1.3
Time in novel zone, NPP test	1.5	1.5	2.3	1.2	-1.2	-1.5	-1.1	-1.1
Total zone transitions, NPP test	0.8	1.2	3.8	-0.9	0.9	0.6	0.3	-2.0
Total locomotion distance, NPP test	1.0	1.3	4.0	-1.1	1.1	0.5	0.3	-2.0
Locomotion velocity, NPP test	1.2	1.6	4.2	-1.2	1.2	0.8	0.6	-2.0
Intraocular pressure	1.0	1.5	4.1	1.1	-1.1	-0.4	-0.7	2.0
Delta distance traveled before/after self-admin	1.6	1.8	2.5	-1.5	1.6	1.5	1.4	-0.3
Delta ambulatory time before/after self-admin	2.0	2.1	3.0	-1.6	1.7	1.6	1.5	-0.5
Parametrial fat weight	0.2	0.4	0.5	-0.5	0.5	0.7	0.7	0.6
Pavlov. Cond. lever latency	0.8	1.0	2.2	1.2	-1.1	-0.4	-0.4	1.5
Pavlov. Cond. magazine entry latency	3.0	3.8	5.9	-2.4	2.4	2.2	1.7	-0.1
Pavlov. Cond. change in total contacts	0.4	0.4	0.9	-1.0	0.9	0.5	0.3	-0.4
Pavlov. Cond. index score	1.5	1.9	3.2	-1.8	1.7	1.1	0.9	-1.0
Pavlov. Cond. latency score	1.9	2.4	3.9	-2.0	1.9	1.2	1.1	-1.4
Pavlov. Cond. lever contacts	1.3	1.5	2.9	-1.4	1.4	0.7	0.7	-1.7
Pavlov. Cond. magazine entry number	1.1	1.4	2.4	1.6	-1.5	-1.2	-0.8	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.2	0.3	-0.3	0.1	-0.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.8	-1.9	1.9	1.4	1.1	-1.0
Pavlov. Cond. response bias	1.6	2.0	3.3	-1.8	1.8	1.4	1.1	-0.3
Pavlov. Cond. lever latency	0.4	0.5	1.4	0.7	-0.6	-0.7	-1.2	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.4	0.7	-0.7	0.7	0.6	0.8	-0.0
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	-0.4	0.4	0.7	1.0	0.3
Pavlov. Cond. index score	0.4	0.6	1.3	-0.7	0.7	0.8	1.1	0.3
Pavlov. Cond. latency score	0.5	0.6	1.4	-0.7	0.7	0.8	1.2	0.0
Pavlov. Cond. lever contacts	0.3	0.4	0.9	-0.5	0.4	0.6	0.9	0.6
Pavlov. Cond. magazine entry number	0.6	0.8	1.2	1.0	-1.0	-0.9	-1.1	0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.0	1.0	-1.0	-0.8	-0.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.4	-0.8	0.8	0.8	1.2	0.1
Pavlov. Cond. response bias	0.8	1.1	2.1	-0.9	0.9	1.2	1.4	0.7
Time in closed arm before self-admin	0.5	0.5	2.3	-0.0	0.1	-0.4	-0.3	-1.5
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	0.0	0.1	0.0	0.3
Time in open arm before self-admin	0.3	0.4	0.6	-0.5	0.6	0.7	0.8	0.3
Time in open arm after self-admin	0.7	0.8	1.1	1.1	-1.1	-1.0	-0.9	0.3
Bone: periosteal estimation	0.1	0.2	0.7	0.2	-0.3	-0.6	-0.0	-0.8
Bone: periosteal perimeter	0.4	0.7	1.4	-0.8	0.8	0.4	1.0	-1.2
Bone: post-yield work	0.4	0.6	0.9	0.7	-0.7	-1.0	-0.9	0.6
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.5	-0.5	-0.4	-0.5	0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	0.6	-0.6	-0.4	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	0.2	0.2	0.1	-0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.0	0.0	0.2	0.0	0.7
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.3	0.3	0.4	0.3	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	0.4	0.3	0.2	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.4	0.1	-0.0	0.1	-0.0	0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.0	0.1	0.2	0.1	0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	-0.2
Progressive ratio	0.2	0.3	0.9	0.2	-0.2	-0.4	-1.0	0.5
Food seeking constrained by brief footshock	0.6	0.7	1.2	-1.1	1.1	0.9	0.2	-0.7
Seeking ratio, punishment vs. effort	0.5	0.6	0.7	-0.8	0.8	0.7	0.7	-0.9
Retroperitoneal fat weight	0.3	0.9	1.4	0.9	-1.0	-0.9	-1.2	0.6
Reaction time number correct	1.9	2.7	3.9	1.7	-1.7	-1.3	-1.3	2.0
Reaction time mean minus median	0.3	0.4	0.6	-0.6	0.6	0.7	0.8	0.4
Reaction time mean minus median AUC	0.2	0.2	0.7	-0.4	0.3	0.1	0.5	-0.8
Reaction time num false alarms	0.5	0.7	1.5	0.7	-0.7	-0.8	-0.4	1.2
Reaction time num false alarms AUC	0.7	1.0	2.3	0.9	-0.9	-0.9	-0.7	1.5
Reaction time trials correct on left	1.9	2.7	3.9	1.7	-1.7	-1.3	-1.3	2.0
Reaction time trials on left	1.8	2.6	3.6	1.7	-1.7	-1.3	-1.3	1.9
Reaction time mean	0.0	0.0	0.1	0.2	-0.1	-0.1	0.3	-0.3
Reaction time mean AUC	0.0	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.4
Median of all reaction times	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.2	-0.5
Reaction time omissions	0.2	0.2	0.5	-0.3	0.4	0.6	0.7	-0.4
Reaction time false alarm rate	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.0	0.1
Reaction time premature initiation rate	0.4	0.5	0.9	-0.5	0.5	1.0	0.8	0.8
Reaction time premature initiations	0.6	0.8	3.6	0.4	-0.4	0.3	0.2	1.9
Std. dev. reaction times	0.1	0.1	0.3	-0.3	0.2	0.3	0.6	0.2
Reaction time trials completed	1.8	2.6	3.6	1.7	-1.7	-1.3	-1.3	1.9
Reaction time trials AUC	2.1	3.0	4.7	1.8	-1.8	-1.3	-1.4	2.2
Run reversals in cocaine runway, females	0.5	0.4	0.5	-0.7	0.7	0.7	0.7	-0.4
Run reversals in cocaine runway, males	1.6	1.6	2.0	-1.4	1.4	1.4	1.3	-0.6
Latency to leave start box in cocaine runway	1.6	1.7	2.6	-1.2	1.2	1.0	1.5	-1.6
Latency to leave start box in cocaine runway, F	1.0	1.1	4.7	-0.4	0.4	0.1	0.7	-2.2
Latency to leave start box in cocaine runway, M	1.4	1.3	1.8	-1.1	1.1	1.3	1.2	1.0
Std. dev. time between licks in bursts	0.9	1.0	2.0	-1.0	1.0	0.9	1.4	-0.6
Total sessions with >9 infusions	0.1	0.1	0.3	0.0	0.1	-0.1	0.2	-0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	0.4	0.4	0.1	-0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2
Short access day 1 total infusions	0.7	0.8	1.2	-0.9	0.9	0.7	0.7	-1.1
Short access day 10 total infusions	0.0	0.1	0.2	0.1	-0.0	0.1	-0.1	0.5
Short access total infusions	0.0	0.0	0.1	-0.1	0.2	0.0	0.1	-0.3
Short access day 1 locomotion	1.3	1.4	1.8	-1.2	1.3	1.2	1.4	-0.9
Short access day 10 total locomotion	2.4	2.7	3.6	-1.8	1.8	1.9	1.9	0.4
Short access total locomotion	0.8	0.9	1.2	-1.0	1.0	0.9	1.1	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.5	0.2
Compulsive drug intake	0.7	0.7	1.1	0.8	-0.8	-1.0	-0.8	-0.6
One hour access (shock baseline)	0.1	0.2	0.7	0.0	0.0	0.1	-0.0	0.9
Social response proportion	1.1	1.2	1.3	-1.2	1.2	1.1	1.0	-1.0
Social responses	6.8	8.7	11.1	-3.3	3.2	3.2	3.3	-1.3
Social time	0.4	0.5	0.9	0.7	-0.6	-0.7	-1.0	-0.4
Soleus weight	7.4	21.7	29.4	5.2	-5.2	-5.4	-4.9	1.1
Bone: stiffness	1.6	2.5	4.6	1.6	-1.6	-2.1	-1.7	-0.1
Tibialis anterior weight	0.9	2.9	4.4	1.8	-1.7	-2.1	-2.0	0.4
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.7	-1.1	1.0	0.9	1.0	-1.3
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.4	0.1	0.1	0.1	-0.2	1.2
Time to tail flick, test, before self-admin	0.8	0.8	1.4	-0.8	0.8	0.7	1.0	-1.2
Time to tail flick, test, after self-admin	0.5	0.5	0.6	-0.8	0.8	0.7	0.7	-0.6
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	3.1	1.1	-1.0	-0.9	-1.2	1.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.2	0.1	0.2	-0.1	0.8
Tibia length	0.6	1.6	2.3	-1.3	1.3	1.5	1.5	0.0
Ambulatory time before self-admin	0.3	0.3	0.4	0.6	-0.6	-0.6	-0.4	-0.3
Ambulatory time after self-admin	0.3	0.4	0.5	-0.7	0.6	0.6	0.7	-0.4
Bone: tissue strength	1.1	1.0	1.6	1.1	-1.1	-1.3	-1.1	-0.2
Total heroin consumption	1.7	2.0	2.6	-1.5	1.5	1.6	1.5	-0.4
Bone: trabecular number	1.8	2.8	3.7	-1.7	1.7	1.3	1.6	-1.9
Bone: trabecular spacing	3.1	4.0	8.0	1.9	-1.9	-1.3	-1.7	2.8
Bone: trabecular thickness	3.0	3.6	12.2	-1.2	1.2	0.6	1.6	-3.5
Bone: trabecular tissue density	1.7	2.4	3.5	1.6	-1.6	-1.6	-1.9	0.9
Water consumed over 24 hours	0.3	0.4	0.6	0.7	-0.7	-0.8	-0.3	-0.6
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.4	0.3	0.4	-0.2