Hub : Genes

F2r

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression F2r 0.74 0.08 0.0e+00 0.81 0.81 0.81 0.81 9.8e-124 1.6e-123 1.9e-123 1.4e-124
2 OFC gene expression F2r 0.85 0.06 0.0e+00 0.48 0.42 0.42 0.48 5.9e-13 4.2e-11 3.3e-11 6.1e-13
3 LHb gene expression F2r 0.79 0.1 2.2e-14 0.4 0.33 0.38 0.38 1.3e-10 1.1e-08 5.8e-10 6.7e-10
4 PL gene expression F2r 0.69 0.07 0.0e+00 0.66 0.68 0.68 0.68 2.1e-95 1.4e-101 7.9e-102 1.8e-102
5 pVTA gene expression F2r 0.25 0.09 0.0e+00 0.24 0.25 0.27 0.24 1.1e-19 4.3e-20 8.1e-22 1.7e-19
6 NAcc gene expression F2r 0.62 0.1 0.0e+00 0.65 0.68 0.68 0.68 3.0e-132 3.9e-141 9.9e-143 1.0e-140
7 BLA gene expression F2r 0.68 0.09 0.0e+00 0.58 0.59 0.58 0.58 4.8e-37 2.7e-38 6.7e-37 4.7e-37
8 Adipose gene expression F2r 0.43 0.11 0.0e+00 0.21 0.34 0.34 0.34 3.2e-23 6.2e-39 6.5e-39 3.1e-39
9 IC gene expression F2r 0.78 0.09 0.0e+00 0.52 0.61 0.59 0.59 3.5e-25 2.3e-31 5.3e-30 3.1e-30
10 Liver gene expression F2r 0.22 0.09 0.0e+00 0.13 0.16 0.14 0.15 3.2e-14 1.5e-17 1.4e-15 4.2e-16
11 Eye gene expression F2r 0.4 0.19 4.0e-03 0.08 0.11 0.04 0.06 2.4e-02 8.8e-03 8.4e-02 4.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.31.91.11.11.11.11.11.01.31.11.11.11.4
Area under the delay curve1.51.74.4-1.2-1.2-1.2-1.0-1.1-0.8-1.0-1.9-1.0-2.1-1.4
BMI with tail2.58.59.4-3.0-3.1-3.1-2.9-2.9-2.7-2.9-3.0-2.7-2.9-2.8
BMI without tail2.26.89.0-2.8-2.8-2.8-2.9-2.9-3.0-2.7-2.1-2.8-1.5-1.6
Body weight2.812.214.6-3.8-3.8-3.8-3.7-3.7-3.7-3.6-3.2-3.5-2.7-2.7
Weight adjusted by age0.00.00.0-0.0-0.1-0.1-0.00.00.10.1-0.1-0.0-0.2-0.1
Bone surface0.00.00.10.10.10.10.10.10.30.3-0.30.2-0.20.0
Bone volume1.01.82.41.41.41.41.41.41.51.61.01.50.91.1
Breakpoint value in progressive ratio session0.20.20.60.50.50.50.50.60.80.3-0.10.3-0.4-0.4
Number of licking bursts0.20.30.7-0.5-0.5-0.5-0.6-0.5-0.6-0.8-0.4-0.5-0.5-0.8
Context. condit. distance diff. score0.81.01.60.91.01.00.90.90.91.21.00.81.11.2
Locomotion velocity, session 10.90.92.00.80.90.90.80.70.71.01.20.61.41.4
Locomotion distance, session 11.82.34.01.41.51.51.31.31.11.51.91.22.01.8
Locomotion velocity, session 20.80.92.10.80.80.80.70.70.61.11.30.61.41.5
Locomotion distance, session 21.82.63.91.51.61.61.51.41.31.71.91.32.01.7
Locomotion velocity, session 31.11.32.01.11.11.11.21.11.31.40.91.00.91.2
Locomotion distance, session 30.20.20.50.40.40.40.50.40.70.7-0.00.6-0.10.1
Stereotopy head waving bouts, day 31.21.42.41.21.11.11.11.10.91.01.60.91.51.3
Stereotopy head waving duration, day 30.00.00.1-0.0-0.1-0.1-0.0-0.0-0.2-0.20.2-0.20.10.1
Locomotion velocity, session 71.11.21.91.21.21.21.31.21.41.30.71.20.30.7
Locomotion distance, session 70.00.00.00.00.00.00.10.10.10.1-0.10.1-0.2-0.2
Stereotopy head waving bouts, day 70.40.41.20.40.40.40.40.40.40.80.80.21.01.1
Stereotopy head waving duration, day 70.10.10.50.10.10.10.20.10.20.40.4-0.10.50.7
Locomotion velocity, session 84.95.910.52.22.22.22.12.01.72.53.01.83.23.1
Locomotion distance, session 81.52.14.31.31.31.31.31.11.11.71.70.91.92.1
Degree of sensitization distance0.10.10.2-0.2-0.2-0.2-0.3-0.2-0.4-0.40.1-0.30.20.0
Degree of sensitization stereotypy0.10.10.20.10.10.10.10.00.30.50.20.00.30.4
Conditioned locomotion0.20.20.8-0.3-0.3-0.3-0.3-0.3-0.2-0.5-0.5-0.3-0.6-0.9
Cocaine response after cond. corrected0.00.00.10.20.30.30.20.20.20.1-0.10.1-0.3-0.3
Cocaine response after cond. not corrected0.00.00.0-0.1-0.0-0.0-0.1-0.1-0.2-0.0-0.1-0.2-0.10.2
Cocaine response before conditioning0.10.10.6-0.2-0.2-0.2-0.2-0.2-0.30.10.1-0.20.50.8
Saline control response1.01.32.1-1.2-1.2-1.2-1.3-1.2-1.3-1.2-0.8-1.4-0.6-0.8
Bone: connectivity density0.10.10.60.20.10.10.30.30.20.40.30.20.50.7
Bone: cortical apparent density2.63.64.82.12.12.12.02.12.21.91.52.21.31.0
Bone: cortical area0.10.20.40.50.50.50.50.50.70.3-0.20.6-0.4-0.3
Bone: cortical porosity0.10.10.60.20.20.20.10.20.2-0.2-0.1-0.0-0.6-0.8
Bone: cortical porosity0.10.10.60.30.30.30.30.40.4-0.1-0.10.1-0.5-0.8
Bone: cortical thickness0.61.11.81.11.21.21.11.21.41.00.51.30.30.2
Bone: cortical thickness0.60.71.3-0.8-0.8-0.8-0.8-0.8-0.7-0.8-1.1-0.6-1.0-0.9
Bone: cortical tissue density2.73.74.92.12.12.12.02.12.22.01.52.21.31.1
Condit. Reinf. active minus inactive responses0.00.10.3-0.00.00.0-0.1-0.1-0.2-0.00.3-0.00.60.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.3-0.3-0.4-0.4-0.5-0.30.2-0.30.60.2
Condit. Reinf. active responses0.00.00.20.10.10.1-0.00.0-0.10.00.30.10.50.1
Condit. Reinf. inactive responses0.10.10.20.40.40.40.40.40.40.30.30.30.30.3
Incentive salience index mean0.20.20.4-0.5-0.4-0.4-0.5-0.5-0.6-0.4-0.2-0.50.1-0.1
Condit. Reinf. lever presses0.10.10.2-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.4-0.3-0.5-0.3
Condit. Reinf. active minus inactive responses0.10.10.30.30.30.30.20.30.40.1-0.20.2-0.4-0.6
Condit. Reinf. active-inactive response ratio0.10.10.2-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.4-0.3-0.4-0.4
Condit. Reinf. active responses0.20.30.60.60.60.60.60.60.80.50.10.6-0.2-0.3
Condit. Reinf. inactive responses0.10.10.2-0.3-0.3-0.3-0.3-0.2-0.1-0.2-0.4-0.3-0.5-0.4
Condit. Reinf. lever presses0.30.40.80.60.60.60.70.70.90.50.00.8-0.3-0.3
Condit. Reinf. lever reinforcers received0.20.20.50.40.50.50.50.50.70.4-0.20.5-0.5-0.6
Conditioned reinforcement - actives0.20.40.8-0.5-0.5-0.5-0.6-0.6-0.8-0.20.4-0.70.90.8
Conditioned reinforcement - inactives0.10.10.2-0.3-0.2-0.2-0.4-0.4-0.4-0.3-0.2-0.3-0.1-0.2
Conditioned locomotion2.12.75.61.41.31.31.41.40.91.52.21.12.32.4
Patch foraging indifference point 0 sec0.81.51.7-1.3-1.3-1.3-1.3-1.3-1.3-1.2-1.3-1.0-1.1-1.2
Patch foraging indifference point AUC0.91.32.1-1.1-1.1-1.1-1.1-1.0-0.9-1.1-1.3-1.1-1.4-1.4
Delay disc. indifference point, 0s delay0.50.52.60.10.00.00.30.30.5-0.2-0.90.2-1.6-1.3
Delay disc. indifference point, 16s delay0.80.91.7-1.0-0.9-0.9-0.9-0.9-0.8-0.7-1.3-0.8-1.2-0.8
Delay disc. indifference point, 2s delay0.50.62.9-0.2-0.2-0.2-0.1-0.00.3-0.3-1.1-0.1-1.7-1.3
Delay disc. indifference point, 24s delay2.93.26.3-1.8-1.8-1.8-1.5-1.5-1.2-1.4-2.4-1.4-2.5-1.9
Delay disc. indifference point, 4s delay0.40.41.9-0.4-0.4-0.4-0.3-0.3-0.1-0.4-1.0-0.3-1.4-0.8
Delay disc. indifference point, 8s delay1.61.93.3-1.4-1.3-1.3-1.3-1.4-1.1-1.1-1.7-1.3-1.8-1.2
Indifference point function ln k0.30.51.30.50.50.50.40.40.30.70.80.41.11.1
Indifference point function log k0.30.51.30.50.50.50.40.40.30.70.80.41.11.1
Patch foraging total patch changes 0 sec0.71.41.5-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.0-1.1-1.2
Patch foraging total patch changes 12 sec1.62.03.5-1.3-1.4-1.4-1.3-1.2-1.2-1.5-1.5-1.0-1.7-1.9
Patch foraging total patch changes 18 sec1.62.45.2-1.4-1.3-1.3-1.4-1.3-1.0-1.5-2.0-1.0-2.1-2.3
Patch foraging total patch changes 24 sec3.76.47.6-2.5-2.5-2.5-2.5-2.4-2.3-2.5-2.7-2.3-2.8-2.7
Patch foraging total patch changes 6 sec1.11.72.8-1.2-1.2-1.2-1.2-1.2-1.0-1.2-1.6-0.9-1.7-1.6
Patch foraging time to switch 0 sec0.10.31.3-0.2-0.2-0.2-0.1-0.10.1-0.2-0.80.0-1.2-0.9
Patch foraging water rate 0 sec0.10.10.3-0.3-0.3-0.3-0.3-0.3-0.5-0.20.2-0.40.50.3
Patch foraging water rate 12 sec0.30.51.30.80.70.70.70.80.40.41.10.60.90.6
Patch foraging water rate 18 sec0.81.32.3-1.2-1.3-1.3-1.2-1.2-1.5-1.3-0.5-1.4-0.4-0.5
Patch foraging water rate 24 sec0.60.91.3-1.0-1.0-1.0-1.0-1.0-1.2-1.0-0.6-1.2-0.5-0.6
Patch foraging water rate 6 sec0.20.30.80.50.50.50.50.50.30.50.70.30.90.9
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.1-0.1-0.1-0.1-0.2-0.4-0.20.4-0.40.50.4
Distance traveled before self-admin0.50.61.3-0.7-0.7-0.7-0.6-0.6-0.4-0.7-1.1-0.5-1.2-1.0
Distance traveled after self-admin2.02.53.0-1.6-1.7-1.7-1.4-1.6-1.5-1.5-1.6-1.6-1.6-1.5
Extensor digitorum longus weight0.10.20.50.40.40.40.50.50.60.60.20.70.30.6
Bone: elastic displacement1.21.42.31.31.31.31.31.31.51.10.71.50.30.3
Bone: elastic work0.60.81.21.01.01.01.11.11.10.90.71.00.40.5
Bone: endosteal estimation0.30.60.8-0.7-0.7-0.7-0.8-0.7-0.7-0.9-0.9-0.7-0.9-0.9
Bone: endosteal perimeter0.20.30.5-0.5-0.5-0.5-0.6-0.6-0.5-0.6-0.7-0.5-0.7-0.6
Epididymis fat weight2.17.410.7-3.0-3.1-3.1-3.0-3.0-3.3-2.8-1.7-3.2-1.1-1.0
Delta time in closed arm before/after self-admin0.30.30.60.50.50.50.50.60.70.50.20.7-0.3-0.3
Delta time in open arm before/after self-admin0.00.00.2-0.00.10.1-0.1-0.20.10.1-0.4-0.0-0.10.1
Diff in mean of infusions in LGA sessions0.91.11.81.21.21.21.21.31.31.10.80.80.50.5
Delay discount exponential model param1.61.74.21.21.21.21.11.10.81.01.81.02.01.4
Extinction: sum of active levers before priming0.10.10.6-0.1-0.1-0.1-0.1-0.0-0.0-0.3-0.2-0.2-0.6-0.8
Active lever presses in extinction session 60.40.41.4-0.4-0.4-0.4-0.3-0.2-0.1-0.4-0.9-0.4-1.2-0.9
Bone: final force0.10.20.80.30.30.30.40.40.60.2-0.40.4-0.9-0.5
Bone: final moment0.10.20.90.30.30.30.40.40.60.1-0.50.4-0.9-0.6
Food consumed during 24 hour testing period1.82.54.4-1.5-1.4-1.4-1.5-1.4-1.1-1.6-2.0-1.1-2.0-2.1
Glucose3.04.75.62.22.22.22.22.12.02.22.22.42.12.2
Heart weight2.33.54.5-2.0-2.0-2.0-2.1-2.1-2.1-2.0-1.5-2.1-1.1-1.1
Delay discount hyperbolic model param1.31.53.81.11.11.10.91.00.70.91.70.91.91.3
Intermittent access intake day 1-15 change0.10.10.30.40.50.50.20.20.20.20.40.50.40.1
Intermittent access intake escalation0.00.10.20.30.40.40.20.10.20.10.20.40.20.0
Intermittent access intake escalation 20.10.10.10.40.40.40.30.30.30.20.30.40.1-0.1
Intermitt. access day 1 inactive lever presses0.41.42.41.31.41.41.31.31.51.20.61.30.20.2
Intermitt. access day 15 inactive lever presses0.20.40.80.60.70.70.70.60.90.5-0.00.8-0.5-0.1
Intermitt. access escalation Index0.00.00.10.10.20.20.10.00.20.1-0.20.4-0.2-0.2
Intermittent access day 1 total infusions4.37.08.3-2.9-2.9-2.9-2.8-2.8-2.7-2.5-2.6-2.8-2.1-1.9
Intermittent access day 15 total infusions1.11.62.1-1.4-1.3-1.3-1.4-1.4-1.3-1.2-1.3-1.2-1.1-1.0
Intermittent access terminal intake (last 3 days)0.91.21.5-1.1-1.1-1.1-1.2-1.2-1.1-1.0-1.0-1.2-0.8-0.9
Intermittent access total infusions1.82.22.5-1.6-1.6-1.6-1.6-1.6-1.5-1.4-1.5-1.5-1.2-1.2
Intermittent access day 1 locomotion0.81.01.4-1.2-1.1-1.1-1.1-1.2-1.0-0.7-1.1-1.2-0.8-0.4
Intermittent access day 15 total locomotion1.12.13.0-1.6-1.5-1.5-1.7-1.7-1.7-1.3-1.2-1.5-0.9-0.7
Intermittent access total locomotion0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.4-0.3-0.6-0.4-0.5-0.3
Intermittent access standard deviation0.10.10.3-0.3-0.4-0.4-0.2-0.2-0.2-0.3-0.4-0.2-0.5-0.4
Left kidney weight4.922.726.5-5.0-5.1-5.1-5.1-5.0-5.2-5.1-4.1-4.9-3.5-3.8
Right kidney weight5.525.128.4-5.3-5.3-5.3-5.3-5.2-5.2-5.3-4.6-5.1-4.0-4.2
Cocaine induced anxiety0.20.30.90.50.50.50.60.50.50.70.60.40.50.9
Post-drug Anxiety0.20.31.60.10.10.10.20.1-0.00.40.6-0.00.81.3
Baseline Anxiety0.10.10.2-0.3-0.3-0.3-0.4-0.4-0.5-0.4-0.1-0.20.20.1
Tail length0.62.44.4-1.7-1.7-1.7-1.8-1.8-2.1-1.6-0.8-1.80.0-0.3
Length with tail0.94.16.6-2.3-2.3-2.3-2.4-2.3-2.6-2.1-1.2-2.3-0.3-0.4
Length without tail1.13.54.4-2.1-2.1-2.1-2.0-2.1-1.9-1.9-1.7-2.0-1.3-1.1
Times rat made contact with spout2.32.73.4-1.7-1.6-1.6-1.8-1.7-1.8-1.9-1.3-1.8-1.2-1.5
Lifetime Intake2.22.63.3-1.8-1.7-1.7-1.8-1.8-1.6-1.5-1.6-1.6-1.4-1.3
Liver weight, left6.210.211.5-3.3-3.4-3.4-3.3-3.3-3.1-3.3-3.4-3.1-2.9-2.8
Liver weight, right2.64.55.6-2.3-2.4-2.4-2.2-2.2-2.3-2.2-2.0-2.1-1.6-1.4
Locomotor activity0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.3-0.1-0.3-0.30.10.1
Locomotor testing distance0.71.21.7-1.3-1.2-1.2-1.3-1.3-1.1-1.0-1.2-1.0-0.7-0.6
Locomotor testing rearing0.20.40.7-0.6-0.7-0.7-0.6-0.6-0.5-0.6-0.8-0.4-0.8-0.8
Locomotion in novel chamber0.50.60.90.90.90.90.80.90.70.60.90.70.80.1
Locomotion in novel chamber post-restriction0.10.10.6-0.00.10.1-0.2-0.1-0.10.10.6-0.20.80.6
Fecal boli incidents, locomotor time 10.71.01.7-0.9-0.9-0.9-1.0-0.9-1.0-1.1-1.0-0.9-0.9-1.3
Change in fecal boli incidents, locomotor task1.71.62.71.21.21.21.21.10.91.21.61.11.61.6
Time >=10cm from walls, locomotor time 12.22.35.51.31.21.21.31.10.61.32.01.02.32.3
Bouts of movement, locomotor time 10.20.20.40.30.40.40.40.40.70.3-0.40.7-0.7-0.5
Total resting periods, locomotor time 10.20.20.40.50.50.50.60.50.60.60.00.7-0.00.3
Rest time, locomotor task time 11.51.93.81.21.21.21.21.10.91.31.70.91.91.9
Distance moved, locomotor task time 10.91.32.1-1.1-1.1-1.1-1.0-1.1-0.9-1.0-1.3-1.0-1.5-1.3
Vertical activity count, locomotor time 10.51.21.8-1.1-1.1-1.1-1.0-1.1-1.0-1.1-1.2-1.0-1.3-1.3
Time >=10cm from walls, locomotor time 20.40.60.90.80.60.60.90.80.40.70.80.80.91.0
Bouts of movement, locomotor time 20.10.20.70.30.40.40.40.30.40.60.30.20.30.8
Total resting periods, locomotor time 20.10.20.60.40.50.50.40.30.50.60.30.20.40.8
Rest time, locomotor task time 20.20.20.60.40.40.40.40.30.30.40.70.30.80.6
Distance moved, locomotor task time 20.10.20.3-0.4-0.5-0.5-0.3-0.3-0.4-0.4-0.4-0.4-0.5-0.2
Vertical activity count, locomotor time 20.10.20.6-0.3-0.3-0.3-0.4-0.4-0.4-0.6-0.4-0.5-0.5-0.8
Light reinforcement 10.30.71.3-0.9-0.9-0.9-1.0-1.0-1.1-0.7-0.2-1.10.2-0.1
Light reinforcement 21.11.62.4-1.4-1.3-1.3-1.5-1.6-1.4-1.3-1.2-1.4-0.6-0.8
Bone: marrow area0.30.60.9-0.7-0.7-0.7-0.8-0.7-0.7-0.9-0.9-0.7-0.9-0.9
Bone: maximum diameter0.81.53.3-1.0-1.0-1.0-1.0-1.0-0.7-1.2-1.6-0.8-1.8-1.8
Bone: maximum force0.10.10.50.10.10.10.20.20.30.0-0.40.0-0.7-0.4
Bone: maximum moment0.10.10.60.10.10.10.20.20.2-0.0-0.40.0-0.8-0.5
Mean time between licks in bursts0.81.92.2-1.4-1.4-1.4-1.4-1.5-1.4-1.3-1.5-1.5-1.2-0.9
Mean num. licks in bursts0.20.20.4-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.6-0.6-0.6-0.4
Cd content in liver0.10.10.30.30.30.30.40.40.50.2-0.00.4-0.3-0.3
Co content in liver0.20.31.00.30.30.30.20.3-0.00.30.80.31.00.8
Cu content in liver0.20.21.4-0.1-0.1-0.1-0.0-0.1-0.20.30.3-0.00.71.2
Fe content in liver0.60.81.51.01.01.01.01.01.20.90.60.90.10.1
K content in liver0.70.61.0-0.8-0.8-0.8-0.8-0.8-0.6-0.7-1.0-0.8-0.9-0.6
Mg content in liver0.10.10.1-0.3-0.3-0.3-0.3-0.2-0.1-0.2-0.3-0.3-0.3-0.1
Mn content in liver1.92.13.31.61.61.61.61.71.81.51.01.60.50.7
Na content in liver0.90.91.8-1.1-1.1-1.1-1.1-1.1-1.2-0.9-0.5-1.3-0.20.0
Rb content in liver0.60.70.9-0.9-0.9-0.9-0.9-0.9-1.0-0.9-0.7-0.8-0.4-0.4
Se content in liver1.11.31.71.21.21.21.21.21.31.31.10.90.81.1
Sr content in liver0.70.60.70.80.80.80.80.80.80.80.60.90.50.5
Zn content in liver0.10.10.3-0.3-0.3-0.3-0.4-0.4-0.6-0.30.2-0.50.50.4
Bone: minimum diameter0.81.51.91.41.41.41.31.31.31.21.01.30.80.9
Time in familiar zone, hab. session 10.00.00.1-0.1-0.1-0.1-0.1-0.1-0.3-0.10.10.00.20.3
Time in novel zone, hab. session 10.80.81.1-0.9-0.9-0.9-0.9-1.0-0.7-0.8-1.0-0.8-0.9-0.9
Total zone transitions, hab. session 11.21.72.11.31.31.31.21.21.21.31.41.11.41.3
Total locomotion distance, hab. session 10.91.21.41.11.21.21.01.01.01.11.21.11.21.0
Locomotion velocity, hab. session 11.42.02.61.51.51.51.41.41.31.31.61.31.51.1
Time in familiar zone, hab. session 21.71.72.4-1.5-1.5-1.5-1.4-1.5-1.6-1.3-1.1-1.5-0.8-0.4
Time in novel zone, hab. session 20.60.61.00.90.90.90.90.91.00.60.51.00.1-0.4
Total zone transitions, hab. session 20.10.10.5-0.00.00.0-0.0-0.1-0.10.20.4-0.20.50.7
Total locomotion distance, hab. session 20.10.10.30.30.40.40.30.30.30.30.50.10.50.2
Locomotion velocity, hab. session 20.10.10.10.30.30.30.20.20.30.30.40.10.30.2
Novel to familiar place preference ratio0.00.00.00.10.10.10.20.20.20.1-0.00.2-0.1-0.2
Novelty place preference0.00.00.10.10.00.00.10.10.1-0.0-0.00.1-0.2-0.3
Time in novel zone, NPP test0.10.10.20.30.30.30.40.40.30.20.30.30.1-0.1
Total zone transitions, NPP test0.71.11.41.01.11.11.01.01.11.21.00.90.91.0
Total locomotion distance, NPP test1.21.72.01.31.41.41.21.21.31.41.41.21.31.0
Locomotion velocity, NPP test0.60.81.10.91.01.00.90.91.01.00.90.90.80.6
Intraocular pressure7.610.912.23.43.43.43.33.43.03.33.53.23.33.0
Delta distance traveled before/after self-admin1.21.31.6-1.1-1.2-1.2-1.0-1.1-1.1-1.1-1.1-1.3-1.1-1.1
Delta ambulatory time before/after self-admin0.81.01.7-1.1-1.1-1.1-1.1-1.1-1.1-1.0-0.8-1.3-0.6-0.7
Parametrial fat weight0.10.10.60.20.20.20.10.3-0.2-0.10.70.10.80.3
Pavlov. Cond. lever latency0.60.81.10.80.80.80.90.80.80.90.91.01.01.0
Pavlov. Cond. magazine entry latency1.51.93.0-1.5-1.5-1.5-1.6-1.6-1.7-1.4-0.8-1.6-0.3-0.5
Pavlov. Cond. change in total contacts0.10.10.2-0.3-0.3-0.3-0.3-0.3-0.4-0.30.0-0.40.1-0.2
Pavlov. Cond. index score1.21.62.2-1.3-1.3-1.3-1.4-1.3-1.3-1.3-1.0-1.5-0.9-1.0
Pavlov. Cond. latency score1.11.32.0-1.2-1.2-1.2-1.3-1.2-1.3-1.3-0.9-1.4-0.8-0.9
Pavlov. Cond. lever contacts0.10.10.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.5-0.2-0.2
Pavlov. Cond. magazine entry number2.83.54.92.02.02.02.12.12.22.01.42.20.91.2
Pavlov. Cond. intertrial magazine entries1.51.84.61.21.21.21.01.10.61.11.81.22.11.8
Pavlov. Cond. lever-magazine prob. diff.0.80.91.4-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.8-1.2-0.7-0.7
Pavlov. Cond. response bias1.72.12.8-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.1-1.7-0.8-0.9
Pavlov. Cond. lever latency0.40.51.1-0.6-0.6-0.6-0.7-0.8-1.0-0.40.2-1.00.70.9
Pavlov. Cond. magazine entry latency3.94.78.0-2.1-2.0-2.0-1.9-1.9-1.5-2.1-2.8-1.6-2.8-2.6
Pavlov. Cond. change in total contacts0.20.41.20.30.30.30.40.40.70.2-0.70.7-1.1-0.9
Pavlov. Cond. index score0.81.03.7-0.6-0.6-0.6-0.5-0.5-0.0-0.7-1.6-0.1-1.9-1.8
Pavlov. Cond. latency score1.31.75.1-1.0-0.9-0.9-0.8-0.8-0.4-1.0-2.0-0.4-2.3-2.1
Pavlov. Cond. lever contacts0.50.61.30.70.70.70.80.81.10.5-0.21.1-0.8-0.9
Pavlov. Cond. magazine entry number3.44.28.51.81.81.81.71.71.21.92.81.32.92.7
Pavlov. Cond. intertrial magazine entries0.40.51.20.60.60.60.70.60.50.81.00.21.01.1
Pavlov. Cond. lever-magazine prob. diff.1.01.34.4-0.8-0.8-0.8-0.6-0.6-0.2-0.8-1.8-0.2-2.1-1.9
Pavlov. Cond. response bias0.30.41.70.20.20.20.30.40.7-0.0-0.70.6-1.2-1.3
Time in closed arm before self-admin0.20.30.90.50.40.40.50.40.20.30.70.21.00.7
Time in closed arm after self-admin0.10.10.20.20.20.20.30.50.50.20.00.4-0.2-0.4
Time in open arm before self-admin1.92.12.9-1.7-1.7-1.7-1.6-1.6-1.6-1.3-0.9-1.7-0.8-0.3
Time in open arm after self-admin0.70.81.5-1.0-0.9-0.9-1.0-1.2-1.1-0.6-0.7-1.0-0.30.1
Bone: periosteal estimation0.10.20.9-0.1-0.1-0.1-0.1-0.10.1-0.3-0.80.0-1.0-1.0
Bone: periosteal perimeter0.10.20.7-0.4-0.3-0.3-0.3-0.4-0.2-0.4-0.8-0.3-0.8-0.6
Bone: post-yield work0.10.20.5-0.5-0.5-0.5-0.4-0.5-0.6-0.4-0.3-0.7-0.2-0.1
Progressive ratio test 1 active lever presses1.72.12.6-1.5-1.5-1.5-1.5-1.5-1.2-1.3-1.6-1.4-1.6-1.4
Progressive ratio test 1 breakpoint1.51.92.4-1.4-1.4-1.4-1.4-1.4-1.1-1.2-1.5-1.3-1.5-1.3
Progressive ratio test 1 inactive lever presses0.81.11.5-1.1-1.0-1.0-1.1-1.1-0.8-0.9-1.2-1.0-1.2-1.1
Progressive ratio test 2 active lever presses3.44.05.1-2.2-2.1-2.1-2.2-2.2-2.1-2.0-1.9-2.1-1.4-1.5
Progressive ratio test 2 breakpoint3.43.94.9-2.2-2.1-2.1-2.2-2.2-2.1-1.9-1.9-2.0-1.4-1.4
Progressive ratio test 2 inactive lever presses0.81.32.2-1.4-1.3-1.3-1.4-1.5-1.5-1.0-0.8-1.3-0.20.1
Incentive Sensitization - Responses2.33.24.3-2.0-1.9-1.9-2.1-2.1-2.1-1.8-1.6-1.9-0.9-1.1
Incentive Sensitization - Breakpoint2.22.94.0-1.9-1.8-1.8-2.0-2.0-2.0-1.7-1.5-1.8-0.8-0.9
Sum of active levers in priming session hrs 5-60.40.40.70.60.50.50.80.70.90.5-0.10.6-0.7-0.4
Progressive ratio0.00.00.10.10.10.10.00.00.30.1-0.20.0-0.1-0.2
Food seeking constrained by brief footshock0.00.00.20.10.10.10.10.20.00.10.10.00.30.4
Seeking ratio, punishment vs. effort0.00.00.1-0.1-0.2-0.2-0.1-0.0-0.3-0.1-0.0-0.00.00.2
Retroperitoneal fat weight1.04.16.8-2.2-2.2-2.2-2.3-2.3-2.6-2.2-1.2-2.3-0.6-0.9
Reaction time number correct1.01.92.31.51.51.51.51.51.51.41.31.41.00.9
Reaction time mean minus median0.00.10.30.10.10.10.20.20.40.1-0.40.4-0.6-0.4
Reaction time mean minus median AUC0.00.00.2-0.1-0.1-0.10.00.10.0-0.1-0.30.1-0.4-0.3
Reaction time num false alarms1.01.42.3-1.3-1.2-1.2-1.4-1.4-1.5-1.3-0.6-1.5-0.4-0.6
Reaction time num false alarms AUC1.32.03.2-1.5-1.5-1.5-1.7-1.7-1.8-1.5-0.8-1.8-0.4-0.5
Reaction time trials correct on left1.01.92.31.51.51.51.51.51.51.41.31.41.00.9
Reaction time trials on left1.22.32.81.71.71.71.71.71.71.61.41.61.10.9
Reaction time mean0.20.40.70.70.60.60.70.70.80.60.20.8-0.0-0.1
Reaction time mean AUC0.10.20.40.50.40.40.50.60.70.40.00.7-0.1-0.2
Median of all reaction times0.20.20.50.50.50.50.60.60.70.50.20.60.1-0.1
Reaction time omissions2.84.16.02.12.22.22.32.12.52.31.32.31.01.4
Reaction time false alarm rate2.83.85.6-2.1-2.1-2.1-2.2-2.2-2.4-2.1-1.4-2.3-0.8-0.9
Reaction time premature initiation rate2.02.74.5-1.9-1.9-1.9-1.9-2.0-2.1-1.6-1.1-1.8-0.5-0.2
Reaction time premature initiations0.20.40.8-0.7-0.7-0.7-0.7-0.7-0.9-0.5-0.2-0.70.20.4
Std. dev. reaction times0.10.30.50.50.50.50.60.60.70.50.10.7-0.0-0.1
Reaction time trials completed1.22.32.81.71.71.71.71.71.71.61.41.61.10.9
Reaction time trials AUC1.22.32.91.71.71.71.71.71.71.61.41.61.00.9
Run reversals in cocaine runway, females0.30.31.50.00.10.1-0.1-0.1-0.30.30.7-0.21.21.2
Run reversals in cocaine runway, males0.30.31.0-0.3-0.4-0.4-0.2-0.2-0.1-0.4-0.6-0.3-1.0-1.0
Latency to leave start box in cocaine runway0.20.20.7-0.2-0.1-0.1-0.2-0.10.2-0.2-0.8-0.1-0.8-0.8
Latency to leave start box in cocaine runway, F0.10.10.5-0.1-0.2-0.2-0.2-0.2-0.1-0.3-0.5-0.2-0.5-0.7
Latency to leave start box in cocaine runway, M0.10.10.20.00.20.2-0.00.10.50.3-0.40.1-0.4-0.0
Std. dev. time between licks in bursts1.82.42.7-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.6-1.3-1.2
Total sessions with >9 infusions1.31.62.1-1.4-1.3-1.3-1.4-1.4-1.3-1.2-1.2-1.3-1.0-1.1
Short access day 1 total inactive lever presses0.30.50.8-0.8-0.8-0.8-0.7-0.8-0.6-0.5-0.9-0.5-0.7-0.2
Short access day 10 total inactive lever presses1.02.43.01.61.51.51.71.71.51.61.51.31.21.5
Short access day 1 total infusions0.50.71.1-0.9-0.8-0.8-1.0-1.1-0.9-0.7-0.7-0.7-0.5-0.6
Short access day 10 total infusions0.70.91.9-0.9-0.8-0.8-0.9-0.8-0.6-0.8-1.2-0.7-1.3-1.4
Short access total infusions1.51.92.3-1.5-1.4-1.4-1.5-1.5-1.3-1.2-1.4-1.3-1.3-1.2
Short access day 1 locomotion0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.3-0.10.1-0.10.10.1
Short access day 10 total locomotion1.32.53.91.81.81.81.91.92.01.51.01.70.2-0.0
Short access total locomotion0.20.20.30.50.50.50.50.50.60.60.40.40.20.1
One hour access (0.3 mA shock)0.80.91.2-1.0-0.9-0.9-1.1-1.0-1.1-1.1-0.8-1.0-0.7-1.0
Compulsive drug intake0.40.40.9-0.7-0.6-0.6-0.9-1.0-0.8-0.6-0.7-0.6-0.3-0.3
One hour access (shock baseline)0.10.20.4-0.3-0.4-0.4-0.3-0.2-0.3-0.4-0.4-0.3-0.6-0.7
Social response proportion7.28.19.83.03.13.12.92.82.92.92.63.02.42.3
Social responses3.14.05.72.02.12.11.81.81.61.92.21.92.42.2
Social time4.76.57.82.62.52.52.82.72.62.82.32.72.12.5
Soleus weight0.30.81.3-1.0-0.9-0.9-1.1-1.1-1.1-0.9-0.5-1.0-0.3-0.3
Bone: stiffness0.10.10.3-0.2-0.2-0.2-0.2-0.2-0.1-0.3-0.5-0.3-0.6-0.4
Tibialis anterior weight2.99.710.63.23.23.23.13.02.93.13.23.23.32.9
Time to tail flick, vehicle, before self-admin0.70.71.0-0.9-0.9-0.9-0.7-0.8-0.7-0.7-1.0-0.8-1.0-0.7
Time to tail flick, vehicle, after self-admin1.01.31.8-1.1-1.2-1.2-0.9-1.1-1.0-1.1-1.3-1.3-1.3-1.0
Time to tail flick, test, before self-admin0.80.93.80.0-0.0-0.00.20.20.6-0.4-1.20.5-2.0-1.9
Time to tail flick, test, after self-admin1.21.22.11.11.11.11.11.00.81.01.40.81.41.3
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.10.10.10.10.1-0.0-0.1-0.0-0.2-0.2
Delta time to tail flick, test, before/after SA3.33.39.31.31.41.41.21.20.71.62.40.93.03.0
Tibia length0.30.91.7-0.9-0.9-0.9-1.0-0.9-0.9-1.1-0.8-1.1-0.9-1.3
Ambulatory time before self-admin0.50.81.6-0.7-0.8-0.8-0.7-0.7-0.5-0.8-1.2-0.6-1.3-1.2
Ambulatory time after self-admin1.21.42.3-1.1-1.2-1.2-1.0-1.1-0.9-1.1-1.4-1.2-1.5-1.5
Bone: tissue strength0.20.20.40.50.50.50.40.50.50.50.60.20.50.4
Total heroin consumption0.91.01.81.21.21.21.11.11.31.00.61.00.30.2
Bone: trabecular number0.10.10.60.10.10.10.20.20.10.50.40.20.50.8
Bone: trabecular spacing0.30.41.5-0.2-0.1-0.1-0.2-0.20.2-0.4-0.9-0.1-1.2-1.2
Bone: trabecular thickness4.65.86.32.42.42.42.42.42.12.52.52.42.52.5
Bone: trabecular tissue density0.20.30.50.60.60.60.60.50.70.60.20.60.10.3
Water consumed over 24 hours1.82.43.2-1.6-1.5-1.5-1.7-1.6-1.6-1.8-1.5-1.3-1.3-1.6
Number of responses in last shaping day0.60.71.6-0.8-0.7-0.7-0.6-0.7-0.4-0.6-1.2-0.3-1.3-1.1