Exoc3l4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Exoc3l4	0.06	0.05	1.7e-05	0.05	0.05	0.05	0.05	1.6e-05	2.3e-05	2.0e-05	2.6e-05
2	Adipose	alternative TSS	XM_006240576.3	0.04	0.04	1.8e-04	0.02	0.03	0.02	0.02	9.4e-04	4.9e-04	1.8e-03	1.1e-03
3	Adipose	alternative TSS	XM_006240576.3	0.04	0.04	7.5e-05	0.03	0.03	0.02	0.03	5.2e-04	2.7e-04	9.0e-04	6.8e-04
4	PL	alternative polyA	NM_001106759.2	0.03	0.02	1.1e-03	0.02	0.02	0.02	0.01	3.4e-03	2.5e-03	4.0e-03	7.2e-03
5	PL	alternative polyA	XM_006240573.5	0.03	0.03	5.5e-04	0.02	0.02	0.02	0.02	1.8e-03	1.0e-03	1.6e-03	3.0e-03
6	PL	alternative polyA	NM_001106759.2	0.03	0.03	4.6e-04	0.02	0.02	0.02	0.02	1.4e-03	9.8e-04	1.8e-03	3.6e-03
7	PL	alternative polyA	XM_063261785.1	0.03	0.03	2.2e-04	0.03	0.03	0.03	0.02	5.0e-04	3.9e-04	7.4e-04	1.4e-03
8	Adipose	gene expression	Exoc3l4	0.2	0.1	0.0e+00	0.22	0.23	0.22	0.22	1.2e-24	8.2e-25	4.9e-24	1.3e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.2	0.4	-0.4	-0.4	0.5	-0.5	0.4	-0.4	0.4
Area under the delay curve	0.1	0.2	0.5	0.7	-0.4	-0.4	0.2	-0.3	0.3	-0.3	0.4
BMI with tail	3.9	13.3	14.6	3.8	-3.8	-3.8	3.5	-3.5	3.5	-3.5	3.7
BMI without tail	2.7	8.2	8.8	2.9	-3.0	-3.0	2.8	-2.8	2.8	-2.8	2.9
Body weight	0.0	0.2	0.3	-0.3	0.3	0.3	-0.5	0.5	-0.5	0.5	-0.3
Weight adjusted by age	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.1
Bone surface	0.0	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.2
Bone volume	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.4	0.4	-0.4	0.3
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.3	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.2
Number of licking bursts	0.1	0.1	0.3	-0.5	0.3	0.3	-0.4	0.4	-0.4	0.4	-0.4
Context. condit. distance diff. score	1.5	1.9	2.0	-1.3	1.4	1.4	-1.4	1.4	-1.4	1.3	-1.4
Locomotion velocity, session 1	0.4	0.4	0.5	-0.7	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.7
Locomotion distance, session 1	0.3	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.5
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.3
Locomotion distance, session 2	0.3	0.4	0.4	0.6	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.6
Locomotion velocity, session 3	0.3	0.3	0.3	0.6	-0.5	-0.5	0.6	-0.6	0.6	-0.6	0.5
Locomotion distance, session 3	0.0	0.0	0.1	-0.3	0.2	0.2	-0.1	0.1	-0.1	0.1	-0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.2	-0.4	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.4
Stereotopy head waving duration, day 3	0.2	0.3	0.3	-0.5	0.5	0.5	-0.5	0.5	-0.5	0.5	-0.5
Locomotion velocity, session 7	0.4	0.5	0.5	0.7	-0.6	-0.6	0.7	-0.7	0.7	-0.7	0.7
Locomotion distance, session 7	0.8	1.0	1.1	1.0	-0.9	-0.9	1.0	-1.0	1.0	-1.0	1.0
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	-0.9	0.8	0.8	-0.7	0.7	-0.7	0.7	-0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.3	-0.6	0.5	0.5	-0.5	0.5	-0.5	0.5	-0.5
Locomotion velocity, session 8	0.1	0.1	0.2	-0.3	0.4	0.4	-0.3	0.3	-0.3	0.3	-0.3
Locomotion distance, session 8	0.0	0.1	0.1	0.3	-0.2	-0.2	0.3	-0.3	0.3	-0.3	0.2
Degree of sensitization distance	0.1	0.1	0.2	0.5	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.4
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.7	0.5	0.5	-0.4	0.4	-0.4	0.4	-0.5
Conditioned locomotion	1.0	1.1	1.2	-1.1	1.1	1.1	-1.1	1.1	-1.1	1.0	-1.1
Cocaine response after cond. corrected	0.4	0.5	0.5	0.6	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.7
Cocaine response after cond. not corrected	1.7	2.1	2.1	1.4	-1.5	-1.5	1.4	-1.4	1.4	-1.4	1.4
Cocaine response before conditioning	2.7	3.2	3.9	2.0	-1.8	-1.8	1.7	-1.7	1.7	-1.7	1.8
Saline control response	0.1	0.2	0.4	0.6	-0.3	-0.3	0.4	-0.4	0.4	-0.4	0.3
Bone: connectivity density	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
Bone: cortical apparent density	7.8	10.7	11.1	-3.1	3.3	3.3	-3.3	3.3	-3.3	3.3	-3.3
Bone: cortical area	0.7	1.1	1.4	-1.1	1.1	1.1	-1.0	1.0	-1.0	1.0	-1.2
Bone: cortical porosity	0.0	0.0	0.1	-0.2	0.1	0.1	-0.0	0.0	-0.0	0.0	-0.1
Bone: cortical porosity	0.2	0.2	0.3	0.3	-0.4	-0.4	0.5	-0.5	0.5	-0.5	0.4
Bone: cortical thickness	0.7	1.2	1.5	-1.1	1.2	1.2	-1.0	1.0	-1.1	1.1	-1.2
Bone: cortical thickness	0.9	1.1	1.3	-1.1	1.1	1.1	-1.0	1.0	-1.0	1.0	-1.1
Bone: cortical tissue density	7.7	10.4	10.8	-3.0	3.3	3.3	-3.3	3.3	-3.3	3.3	-3.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	0.6	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.7
Condit. Reinf. active-inactive response ratio	2.5	2.6	2.7	1.5	-1.7	-1.7	1.6	-1.6	1.6	-1.6	1.6
Condit. Reinf. active responses	0.2	0.3	0.3	0.4	-0.5	-0.5	0.5	-0.5	0.5	-0.5	0.5
Condit. Reinf. inactive responses	1.8	2.2	2.2	-1.4	1.5	1.5	-1.5	1.5	-1.5	1.5	-1.5
Incentive salience index mean	0.4	0.5	0.6	0.6	-0.8	-0.8	0.7	-0.7	0.7	-0.7	0.7
Condit. Reinf. lever presses	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.5	0.5	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.4	0.5	0.5	-0.6	0.6	-0.6	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	-0.5	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.6
Condit. Reinf. active responses	0.0	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.3
Condit. Reinf. inactive responses	0.8	1.0	1.1	0.8	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0
Condit. Reinf. lever presses	1.9	2.6	3.0	1.7	-1.6	-1.6	1.6	-1.6	1.6	-1.6	1.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2	-0.2	0.2	-0.2	0.3
Conditioned reinforcement - actives	0.4	0.7	0.9	-0.9	0.8	0.8	-0.8	0.8	-0.8	0.8	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.6	0.4	0.4	-0.3	0.3	-0.3	0.3	-0.4
Conditioned locomotion	0.5	0.7	0.8	0.8	-0.8	-0.8	0.9	-0.9	0.9	-0.9	0.8
Patch foraging indifference point 0 sec	2.4	4.4	4.7	-1.8	2.2	2.2	-2.1	2.1	-2.1	2.1	-2.1
Patch foraging indifference point AUC	1.8	2.6	2.8	-1.3	1.6	1.6	-1.7	1.7	-1.7	1.7	-1.6
Delay disc. indifference point, 0s delay	0.1	0.2	0.2	-0.0	0.4	0.4	-0.5	0.4	-0.4	0.4	-0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.4	-0.3	-0.3	0.2	-0.2	0.2	-0.2	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.5	0.7	-0.2	-0.2	0.1	-0.1	0.2	-0.1	0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.3	-0.3	-0.3	0.1	-0.1	0.2	-0.1	0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.2	0.4	0.4	-0.5	0.5	-0.5	0.5	-0.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	0.9	-0.6	-0.6	0.5	-0.5	0.5	-0.5	0.7
Indifference point function ln k	0.3	0.6	0.9	-1.0	0.7	0.7	-0.7	0.7	-0.7	0.7	-0.8
Indifference point function log k	0.3	0.6	0.9	-1.0	0.7	0.7	-0.7	0.7	-0.7	0.7	-0.8
Patch foraging total patch changes 0 sec	2.5	4.7	5.0	-1.9	2.2	2.2	-2.2	2.2	-2.2	2.2	-2.1
Patch foraging total patch changes 12 sec	3.1	4.0	4.4	-1.6	2.1	2.1	-2.1	2.1	-2.1	2.1	-2.0
Patch foraging total patch changes 18 sec	0.8	1.3	1.5	-0.8	1.2	1.2	-1.2	1.2	-1.2	1.1	-1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.1	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.3
Patch foraging total patch changes 6 sec	1.6	2.4	2.8	-1.1	1.6	1.6	-1.7	1.7	-1.6	1.6	-1.5
Patch foraging time to switch 0 sec	7.9	16.2	17.3	4.2	-4.0	-4.0	4.0	-4.0	4.0	-4.0	4.0
Patch foraging water rate 0 sec	13.5	28.5	28.8	-5.2	5.4	5.4	-5.4	5.4	-5.4	5.4	-5.3
Patch foraging water rate 12 sec	7.2	15.1	15.5	-3.9	3.8	3.8	-3.9	3.9	-3.9	3.9	-3.8
Patch foraging water rate 18 sec	4.8	7.4	9.3	-3.1	2.7	2.7	-2.7	2.7	-2.7	2.7	-2.7
Patch foraging water rate 24 sec	4.1	5.8	5.9	-2.4	2.4	2.4	-2.4	2.4	-2.4	2.4	-2.4
Patch foraging water rate 6 sec	4.3	6.2	6.5	-2.5	2.5	2.5	-2.5	2.5	-2.5	2.5	-2.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.3	-0.4	0.5	0.5	-0.6	0.6	-0.6	0.6	-0.5
Distance traveled before self-admin	0.4	0.5	0.7	0.4	-0.8	-0.8	0.7	-0.7	0.7	-0.7	0.8
Distance traveled after self-admin	0.1	0.1	0.3	-0.5	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.2
Extensor digitorum longus weight	5.7	22.3	22.5	-4.7	4.7	4.7	-4.7	4.7	-4.7	4.7	-4.7
Bone: elastic displacement	0.6	0.7	1.0	-1.0	0.8	0.8	-0.8	0.8	-0.8	0.8	-0.9
Bone: elastic work	0.3	0.4	0.7	-0.8	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.7
Bone: endosteal estimation	0.2	0.5	0.6	0.6	-0.8	-0.8	0.7	-0.7	0.7	-0.7	0.7
Bone: endosteal perimeter	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.1	-0.1	0.1	-0.1	0.1
Epididymis fat weight	2.7	9.4	9.8	3.0	-3.1	-3.1	3.0	-3.0	3.0	-3.0	3.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Delta time in open arm before/after self-admin	0.8	0.8	0.8	-0.8	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	0.0	0.0	0.1	-0.1	0.1	-0.1	0.0
Delay discount exponential model param	0.1	0.1	0.5	-0.7	0.4	0.4	-0.2	0.2	-0.3	0.2	-0.4
Extinction: sum of active levers before priming	0.3	0.4	0.6	0.8	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.6
Active lever presses in extinction session 6	1.3	1.3	1.4	-0.9	1.2	1.2	-1.2	1.2	-1.2	1.2	-1.2
Bone: final force	0.2	0.3	0.5	-0.7	0.6	0.6	-0.5	0.5	-0.5	0.5	-0.7
Bone: final moment	0.3	0.4	0.7	-0.8	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.7
Food consumed during 24 hour testing period	0.1	0.1	0.1	-0.4	0.3	0.3	-0.4	0.4	-0.4	0.4	-0.4
Glucose	0.7	1.1	1.2	-1.1	1.1	1.1	-1.0	1.0	-1.0	1.0	-1.0
Heart weight	0.5	0.8	0.8	-0.9	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.9
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.7	0.3	0.3	-0.2	0.2	-0.2	0.2	-0.3
Intermittent access intake day 1-15 change	1.5	3.2	3.3	1.8	-1.8	-1.8	1.8	-1.8	1.8	-1.8	1.7
Intermittent access intake escalation	1.5	3.0	3.2	1.7	-1.7	-1.7	1.8	-1.8	1.8	-1.8	1.7
Intermittent access intake escalation 2	0.6	0.7	0.8	0.7	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.8
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.4	-1.2	0.8	0.8	-0.7	0.7	-0.7	0.7	-0.8
Intermitt. access day 15 inactive lever presses	0.7	1.5	2.4	-1.5	1.2	1.2	-1.2	1.2	-1.2	1.2	-1.2
Intermitt. access escalation Index	0.3	0.4	0.6	0.0	0.7	0.7	-0.8	0.8	-0.8	0.8	-0.6
Intermittent access day 1 total infusions	0.3	0.5	0.5	0.7	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.7
Intermittent access day 15 total infusions	1.5	2.2	3.1	1.8	-1.4	-1.4	1.4	-1.4	1.4	-1.4	1.4
Intermittent access terminal intake (last 3 days)	2.1	2.8	3.0	1.7	-1.6	-1.6	1.7	-1.7	1.7	-1.7	1.6
Intermittent access total infusions	1.0	1.2	1.6	1.3	-1.1	-1.1	1.1	-1.1	1.1	-1.1	1.1
Intermittent access day 1 locomotion	1.8	2.3	2.5	1.2	-1.6	-1.6	1.6	-1.6	1.6	-1.6	1.6
Intermittent access day 15 total locomotion	0.2	0.3	0.4	0.7	-0.5	-0.5	0.6	-0.6	0.6	-0.6	0.5
Intermittent access total locomotion	0.9	1.1	1.3	1.2	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0
Intermittent access standard deviation	1.8	3.7	4.0	1.5	-2.0	-2.0	2.0	-2.0	2.0	-2.0	1.9
Left kidney weight	0.7	3.2	3.3	-1.6	1.8	1.8	-1.8	1.8	-1.8	1.8	-1.8
Right kidney weight	0.5	2.5	2.7	-1.5	1.6	1.6	-1.6	1.6	-1.6	1.6	-1.5
Cocaine induced anxiety	2.7	3.8	5.0	-2.2	1.9	1.9	-1.9	1.9	-1.9	1.9	-1.9
Post-drug Anxiety	5.0	5.4	5.4	-2.2	2.3	2.3	-2.3	2.3	-2.3	2.3	-2.3
Baseline Anxiety	0.1	0.1	0.5	0.7	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Tail length	3.6	14.2	14.9	-3.9	3.7	3.7	-3.7	3.7	-3.7	3.7	-3.8
Length with tail	5.5	23.8	25.4	-5.0	4.9	4.9	-4.9	4.9	-4.9	4.9	-4.9
Length without tail	2.5	7.9	9.2	-3.0	2.8	2.8	-2.8	2.8	-2.8	2.8	-2.7
Times rat made contact with spout	0.3	0.3	0.4	-0.5	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.6
Lifetime Intake	0.6	0.7	0.9	1.0	-0.8	-0.8	0.9	-0.9	0.9	-0.9	0.8
Liver weight, left	2.4	4.0	5.1	-2.3	1.9	1.9	-2.0	2.0	-2.0	2.0	-1.9
Liver weight, right	0.5	0.9	1.0	0.7	-1.0	-1.0	0.9	-0.9	0.9	-0.9	1.0
Locomotor activity	0.0	0.1	0.1	-0.3	0.3	0.3	-0.2	0.2	-0.2	0.2	-0.2
Locomotor testing distance	0.1	0.2	0.3	0.0	0.5	0.5	-0.4	0.4	-0.4	0.4	-0.4
Locomotor testing rearing	1.6	3.2	4.1	2.0	-1.7	-1.7	1.8	-1.8	1.8	-1.8	1.8
Locomotion in novel chamber	2.9	3.8	3.9	-1.9	1.9	1.9	-2.0	2.0	-2.0	2.0	-1.9
Locomotion in novel chamber post-restriction	0.0	0.0	0.2	-0.4	-0.0	-0.0	-0.0	0.0	-0.0	0.0	-0.0
Fecal boli incidents, locomotor time 1	1.1	1.6	1.8	1.3	-1.4	-1.4	1.2	-1.2	1.2	-1.2	1.3
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.7	0.8	-0.7	-0.7	0.6	-0.6	0.6	-0.6	0.7
Bouts of movement, locomotor time 1	0.9	1.0	1.2	1.1	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0
Total resting periods, locomotor time 1	1.0	1.1	1.3	1.2	-1.1	-1.1	1.0	-1.0	1.0	-1.0	1.0
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.2	0.4	0.4	-0.5	0.5	-0.5	0.5	-0.4
Distance moved, locomotor task time 1	0.3	0.5	0.6	0.3	-0.7	-0.7	0.8	-0.8	0.8	-0.8	0.7
Vertical activity count, locomotor time 1	0.3	0.6	1.2	-1.1	0.8	0.8	-0.7	0.7	-0.7	0.7	-0.8
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.5	-0.6	0.7	0.7	-0.6	0.6	-0.6	0.7	-0.7
Bouts of movement, locomotor time 2	1.7	2.6	2.8	-1.4	1.6	1.6	-1.7	1.7	-1.7	1.7	-1.7
Total resting periods, locomotor time 2	1.2	2.1	2.3	-1.2	1.4	1.4	-1.5	1.5	-1.5	1.5	-1.5
Rest time, locomotor task time 2	0.4	0.5	0.6	-0.5	0.7	0.7	-0.8	0.8	-0.8	0.8	-0.7
Distance moved, locomotor task time 2	0.4	0.4	0.6	0.3	-0.6	-0.6	0.8	-0.8	0.7	-0.8	0.7
Vertical activity count, locomotor time 2	0.4	0.5	1.1	-1.0	0.7	0.7	-0.6	0.6	-0.6	0.6	-0.7
Light reinforcement 1	0.0	0.1	0.2	0.5	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Light reinforcement 2	1.0	1.5	1.6	1.1	-1.2	-1.2	1.3	-1.3	1.3	-1.3	1.2
Bone: marrow area	0.2	0.4	0.5	0.5	-0.7	-0.7	0.6	-0.6	0.6	-0.6	0.6
Bone: maximum diameter	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	0.2	-0.2	0.2	-0.2
Bone: maximum force	0.1	0.1	0.3	-0.5	0.4	0.4	-0.3	0.3	-0.3	0.3	-0.4
Bone: maximum moment	0.1	0.1	0.3	-0.6	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.4
Mean time between licks in bursts	0.5	1.2	1.2	1.1	-1.1	-1.1	1.1	-1.1	1.1	-1.1	1.1
Mean num. licks in bursts	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	0.1	-0.1	0.0
Cd content in liver	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	-0.0	0.0	0.0
Co content in liver	1.1	1.2	1.4	-1.2	1.1	1.1	-1.1	1.1	-1.1	1.1	-1.1
Cu content in liver	0.5	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.8
Fe content in liver	0.3	0.4	0.5	0.6	-0.7	-0.7	0.6	-0.6	0.6	-0.6	0.7
K content in liver	0.3	0.3	0.4	-0.7	0.6	0.6	-0.5	0.5	-0.5	0.5	-0.5
Mg content in liver	0.2	0.2	0.2	-0.5	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.4
Mn content in liver	0.3	0.4	0.4	0.5	-0.6	-0.6	0.7	-0.7	0.7	-0.7	0.6
Na content in liver	0.0	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.1	0.1	-0.1	0.1
Rb content in liver	0.7	0.8	0.9	-0.8	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.9
Se content in liver	0.0	0.0	0.1	-0.1	-0.3	-0.3	0.2	-0.2	0.2	-0.2	0.2
Sr content in liver	0.4	0.3	0.4	-0.5	0.5	0.5	-0.6	0.6	-0.6	0.6	-0.6
Zn content in liver	1.9	2.1	2.4	-1.6	1.3	1.3	-1.4	1.4	-1.4	1.5	-1.4
Bone: minimum diameter	0.4	0.8	0.8	-0.8	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.9
Time in familiar zone, hab. session 1	0.9	0.8	0.9	1.0	-0.9	-0.9	0.9	-0.9	0.9	-0.9	1.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0	0.0	-0.0	0.0
Total zone transitions, hab. session 1	0.6	0.8	0.8	0.8	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.9
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.5	0.5	-0.7	0.7	0.7	-0.7	0.7	-0.7	0.7	-0.7
Time in familiar zone, hab. session 2	0.9	1.0	1.2	1.1	-0.9	-0.9	1.0	-1.0	1.0	-1.0	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.0	-0.0	-0.1	0.1	-0.1	0.1	-0.1
Total zone transitions, hab. session 2	0.6	0.7	0.8	0.7	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.8
Total locomotion distance, hab. session 2	0.5	0.6	0.8	-0.9	0.8	0.8	-0.8	0.8	-0.8	0.8	-0.9
Locomotion velocity, hab. session 2	0.7	0.9	1.2	-1.1	1.0	1.0	-0.9	0.9	-0.9	0.9	-1.0
Novel to familiar place preference ratio	0.2	0.2	0.2	0.4	-0.5	-0.5	0.5	-0.5	0.5	-0.5	0.4
Novelty place preference	0.1	0.1	0.1	0.3	-0.4	-0.4	0.4	-0.4	0.4	-0.4	0.3
Time in novel zone, NPP test	0.1	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.3
Total zone transitions, NPP test	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.2
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.5	0.3	0.3	-0.2	0.2	-0.2	0.2	-0.4
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.5	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.4
Intraocular pressure	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.1	0.1	-0.1	0.0
Delta ambulatory time before/after self-admin	0.4	0.5	0.6	-0.4	0.8	0.8	-0.7	0.7	-0.7	0.7	-0.8
Parametrial fat weight	0.3	0.7	0.8	0.7	-0.9	-0.9	0.8	-0.8	0.8	-0.8	0.9
Pavlov. Cond. lever latency	0.5	0.6	0.6	-0.7	0.8	0.8	-0.8	0.8	-0.8	0.8	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	1.0	-0.8	-0.8	0.9	-0.9	0.9	-0.9	0.9
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	0.7	-0.6	-0.6	0.6	-0.6	0.7	-0.7	0.7
Pavlov. Cond. index score	0.9	1.1	1.1	1.1	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0
Pavlov. Cond. latency score	0.5	0.7	0.7	0.9	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.8
Pavlov. Cond. lever contacts	1.0	1.1	1.2	1.0	-1.1	-1.1	1.1	-1.1	1.1	-1.1	1.1
Pavlov. Cond. magazine entry number	1.1	1.4	1.5	-1.2	1.1	1.1	-1.2	1.2	-1.2	1.2	-1.2
Pavlov. Cond. intertrial magazine entries	5.5	6.6	7.2	-2.7	2.6	2.6	-2.5	2.5	-2.5	2.5	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.8	0.9	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.9
Pavlov. Cond. response bias	1.7	2.1	2.2	1.5	-1.4	-1.4	1.5	-1.5	1.5	-1.5	1.4
Pavlov. Cond. lever latency	2.4	3.2	3.6	-1.9	1.8	1.8	-1.8	1.8	-1.8	1.8	-1.7
Pavlov. Cond. magazine entry latency	5.0	6.0	6.6	2.6	-2.5	-2.5	2.4	-2.4	2.4	-2.4	2.5
Pavlov. Cond. change in total contacts	3.8	6.1	6.3	2.5	-2.5	-2.5	2.5	-2.5	2.5	-2.5	2.5
Pavlov. Cond. index score	5.4	7.3	8.0	2.8	-2.7	-2.7	2.7	-2.7	2.7	-2.7	2.7
Pavlov. Cond. latency score	5.3	7.1	7.6	2.8	-2.6	-2.6	2.6	-2.6	2.6	-2.6	2.6
Pavlov. Cond. lever contacts	3.1	4.3	4.7	2.2	-2.1	-2.1	2.1	-2.1	2.1	-2.1	2.0
Pavlov. Cond. magazine entry number	4.8	5.9	6.4	-2.5	2.4	2.4	-2.4	2.4	-2.4	2.4	-2.5
Pavlov. Cond. intertrial magazine entries	4.2	6.3	6.5	-2.5	2.6	2.6	-2.5	2.5	-2.5	2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	6.1	8.2	9.0	3.0	-2.8	-2.8	2.8	-2.8	2.8	-2.8	2.8
Pavlov. Cond. response bias	4.3	5.9	6.4	2.5	-2.4	-2.4	2.4	-2.4	2.4	-2.4	2.4
Time in closed arm before self-admin	1.6	2.0	2.2	1.5	-1.4	-1.4	1.4	-1.4	1.4	-1.4	1.4
Time in closed arm after self-admin	0.7	0.8	0.8	0.7	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.9
Time in open arm before self-admin	1.9	2.1	2.2	-1.4	1.5	1.5	-1.5	1.5	-1.5	1.5	-1.4
Time in open arm after self-admin	2.0	2.2	2.3	-1.4	1.5	1.5	-1.5	1.5	-1.5	1.5	-1.4
Bone: periosteal estimation	0.1	0.1	0.2	-0.4	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.4
Bone: periosteal perimeter	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	0.2	-0.2	0.2	-0.2
Bone: post-yield work	1.1	1.6	1.7	-1.3	1.3	1.3	-1.2	1.2	-1.2	1.2	-1.3
Progressive ratio test 1 active lever presses	0.3	0.4	0.6	0.8	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.6
Progressive ratio test 1 breakpoint	0.5	0.6	0.7	0.9	-0.7	-0.7	0.8	-0.8	0.8	-0.8	0.8
Progressive ratio test 1 inactive lever presses	1.1	1.6	3.0	-1.7	1.3	1.3	-1.1	1.1	-1.2	1.1	-1.3
Progressive ratio test 2 active lever presses	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.2
Progressive ratio test 2 breakpoint	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.6	1.0	1.7	-1.3	1.0	1.0	-1.0	1.0	-1.0	1.0	-0.9
Incentive Sensitization - Responses	0.1	0.2	0.4	-0.6	0.3	0.3	-0.4	0.4	-0.4	0.4	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.6	0.4	0.4	-0.5	0.5	-0.5	0.5	-0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.0	0.3	0.3	-0.2	0.2	-0.2	0.2	-0.3
Progressive ratio	0.1	0.2	0.2	-0.4	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.5
Food seeking constrained by brief footshock	2.1	2.6	2.9	-1.4	1.7	1.7	-1.6	1.6	-1.6	1.6	-1.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.3	0.4	0.4	-0.3	0.3	-0.3	0.3	-0.4
Retroperitoneal fat weight	0.1	0.4	0.5	0.5	-0.7	-0.7	0.6	-0.6	0.6	-0.6	0.7
Reaction time number correct	2.0	3.9	4.1	-2.0	2.0	2.0	-2.0	2.0	-2.0	2.0	-1.9
Reaction time mean minus median	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.2	0.2	-0.2	0.2
Reaction time num false alarms	0.6	0.9	1.0	-0.6	1.0	1.0	-1.0	1.0	-1.0	1.0	-0.9
Reaction time num false alarms AUC	1.0	1.6	1.8	-1.0	1.3	1.3	-1.3	1.3	-1.3	1.3	-1.3
Reaction time trials correct on left	2.0	3.9	4.1	-2.0	2.0	2.0	-2.0	2.0	-2.0	2.0	-1.9
Reaction time trials on left	2.1	3.9	4.1	-2.0	2.0	2.0	-2.0	2.0	-2.0	2.0	-1.9
Reaction time mean	0.6	1.0	1.1	0.9	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0
Reaction time mean AUC	0.4	0.6	0.7	0.5	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.8
Median of all reaction times	0.5	0.7	0.7	0.7	-0.9	-0.9	0.8	-0.8	0.8	-0.8	0.8
Reaction time omissions	0.5	0.7	0.9	-0.9	0.8	0.8	-0.8	0.8	-0.8	0.9	-0.8
Reaction time false alarm rate	0.1	0.1	0.1	-0.0	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.3
Reaction time premature initiation rate	0.8	1.1	1.2	-0.8	1.1	1.1	-1.1	1.1	-1.1	1.1	-1.0
Reaction time premature initiations	1.9	3.3	3.5	-1.6	1.9	1.9	-1.9	1.9	-1.9	1.9	-1.8
Std. dev. reaction times	0.1	0.2	0.2	0.2	-0.5	-0.5	0.4	-0.4	0.4	-0.4	0.4
Reaction time trials completed	2.1	3.9	4.1	-2.0	2.0	2.0	-2.0	2.0	-2.0	2.0	-1.9
Reaction time trials AUC	2.2	4.2	4.4	-2.1	2.1	2.1	-2.1	2.1	-2.0	2.0	-2.0
Run reversals in cocaine runway, females	0.6	0.6	0.7	0.8	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.8
Run reversals in cocaine runway, males	1.2	1.2	1.9	-1.4	1.1	1.1	-1.0	1.0	-1.0	1.0	-1.1
Latency to leave start box in cocaine runway	0.3	0.3	1.0	1.0	-0.4	-0.4	0.4	-0.4	0.4	-0.4	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.9	0.9	-0.3	-0.3	0.3	-0.3	0.3	-0.4	0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	-0.3	-0.3	0.2	-0.2	0.2	-0.2	0.3
Std. dev. time between licks in bursts	0.7	0.9	1.0	1.0	-0.9	-0.9	1.0	-1.0	1.0	-1.0	0.9
Total sessions with >9 infusions	0.4	0.5	0.5	0.5	-0.6	-0.6	0.7	-0.7	0.7	-0.7	0.7
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.1	0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1	-0.1	0.1	-0.1	0.1
Short access day 1 total infusions	0.1	0.1	0.2	-0.3	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.4
Short access day 10 total infusions	1.0	1.3	1.5	1.2	-1.1	-1.1	1.1	-1.1	1.1	-1.1	1.1
Short access total infusions	0.3	0.4	0.5	0.7	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.6
Short access day 1 locomotion	0.5	0.6	0.7	0.7	-0.7	-0.7	0.8	-0.8	0.8	-0.8	0.8
Short access day 10 total locomotion	1.9	3.5	3.9	1.5	-1.9	-1.9	2.0	-2.0	2.0	-2.0	1.9
Short access total locomotion	0.4	0.5	0.5	0.5	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.7
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
Compulsive drug intake	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Social response proportion	0.2	0.2	0.6	-0.8	0.4	0.4	-0.5	0.5	-0.5	0.5	-0.4
Social responses	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Social time	0.8	1.1	1.3	-1.1	1.0	1.0	-1.1	1.1	-1.1	1.1	-1.0
Soleus weight	0.1	0.2	0.2	0.4	-0.4	-0.4	0.5	-0.5	0.5	-0.5	0.5
Bone: stiffness	1.0	1.7	2.1	-1.5	1.3	1.3	-1.2	1.2	-1.2	1.2	-1.4
Tibialis anterior weight	0.2	0.7	0.7	-0.7	0.8	0.8	-0.8	0.8	-0.8	0.8	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.4	-0.5	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.4	0.6	0.6	0.6	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.7
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
Time to tail flick, test, after self-admin	0.8	0.9	1.4	-1.2	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2
Delta time to tail flick, test, before/after SA	0.5	0.5	1.1	-1.1	0.6	0.6	-0.7	0.7	-0.7	0.7	-0.6
Tibia length	0.6	1.8	2.4	-1.5	1.3	1.3	-1.3	1.3	-1.3	1.3	-1.4
Ambulatory time before self-admin	0.5	0.7	1.0	0.4	-0.9	-0.9	0.9	-0.9	0.9	-0.9	1.0
Ambulatory time after self-admin	0.1	0.2	0.2	0.3	-0.4	-0.4	0.4	-0.4	0.4	-0.4	0.4
Bone: tissue strength	0.4	0.4	0.5	-0.7	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.7
Total heroin consumption	2.6	3.1	3.5	-1.6	1.8	1.8	-1.7	1.7	-1.7	1.7	-1.9
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.1	0.1
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.4	-0.2	-0.2	0.3	-0.3	0.3	-0.3	0.3
Bone: trabecular tissue density	0.0	0.0	0.0	-0.1	0.2	0.2	-0.1	0.1	-0.1	0.1	-0.1
Water consumed over 24 hours	2.4	3.3	3.5	-1.6	1.8	1.8	-1.9	1.9	-1.9	1.9	-1.8
Number of responses in last shaping day	0.1	0.1	0.1	-0.1	-0.4	-0.4	0.3	-0.3	0.3	-0.3	0.3