Exoc3l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Exoc3l1	0.04	0.04	1.7e-03	0.02	0.02	0.02	0.02	2.3e-03	4.9e-03	1.1e-02	5.4e-03
2	Brain	intron excision ratio	chr19_50079034_50079134	0.05	0.04	4.4e-04	0.01	0.03	0.01	0.02	1.2e-02	1.0e-03	4.1e-02	8.5e-03
3	Eye	alternative TSS	NM_001106178.1	0.88	0.1	4.8e-03	0.08	0.04	0.04	0.08	2.4e-02	8.2e-02	9.8e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.1	0.2	0.5	-0.3	0.3
Area under the delay curve	0.0	0.0	0.0	0.0	0.0	-0.2
BMI with tail	0.0	0.1	0.1	0.3	-0.3	-0.3
BMI without tail	0.0	0.0	0.0	-0.2	-0.0	-0.0
Body weight	0.3	1.4	1.5	1.2	-1.2	-1.2
Weight adjusted by age	0.0	0.1	0.2	0.0	-0.1	0.4
Bone surface	1.2	2.2	3.0	1.7	-1.5	-1.1
Bone volume	0.9	1.7	2.5	1.6	-1.4	-0.8
Breakpoint value in progressive ratio session	2.1	2.6	3.0	-1.5	1.6	1.7
Number of licking bursts	0.6	0.9	1.1	1.0	-0.9	-0.9
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	0.2	-0.1
Locomotion velocity, session 1	0.1	0.1	0.2	0.3	-0.2	-0.4
Locomotion distance, session 1	0.0	0.1	0.1	-0.3	0.3	-0.0
Locomotion velocity, session 2	0.5	0.6	0.8	-0.9	0.8	0.6
Locomotion distance, session 2	0.1	0.1	0.2	-0.4	0.3	-0.1
Locomotion velocity, session 3	0.3	0.3	0.4	-0.5	0.6	0.6
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	0.2	-0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.2	-0.3	-0.4
Stereotopy head waving duration, day 3	0.4	0.5	0.6	0.7	-0.8	-0.5
Locomotion velocity, session 7	0.1	0.1	0.3	0.1	0.1	0.5
Locomotion distance, session 7	0.0	0.1	0.1	-0.2	0.2	0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	-0.3	0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.8	-0.6	-0.4
Locomotion velocity, session 8	0.2	0.3	0.7	0.1	0.2	0.8
Locomotion distance, session 8	0.2	0.3	0.5	-0.6	0.7	0.2
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.1	0.1
Degree of sensitization stereotypy	0.2	0.2	0.3	0.6	-0.5	-0.2
Conditioned locomotion	2.2	2.5	2.7	1.5	-1.6	-1.6
Cocaine response after cond. corrected	0.2	0.3	0.4	0.6	-0.6	-0.3
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.1	0.0	0.1
Cocaine response before conditioning	1.1	1.3	1.7	-1.3	1.3	0.7
Saline control response	4.5	5.9	6.5	2.4	-2.5	-2.4
Bone: connectivity density	0.1	0.2	0.4	-0.1	0.3	0.6
Bone: cortical apparent density	1.1	1.5	2.0	-1.0	1.2	1.4
Bone: cortical area	0.3	0.5	0.8	0.9	-0.7	-0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.5	0.4	-0.0
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.4	-0.0
Bone: cortical thickness	0.2	0.3	0.4	0.6	-0.4	0.5
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.2	0.0
Bone: cortical tissue density	1.1	1.5	2.0	-1.0	1.2	1.4
Condit. Reinf. active minus inactive responses	3.7	4.1	4.7	-2.1	2.2	1.8
Condit. Reinf. active-inactive response ratio	3.1	3.3	4.1	-2.0	2.0	1.4
Condit. Reinf. active responses	2.5	3.1	3.6	-1.9	1.9	1.4
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.5	0.4	0.3
Incentive salience index mean	1.9	2.3	2.5	-1.5	1.6	1.4
Condit. Reinf. lever presses	0.2	0.2	0.5	-0.3	0.4	0.7
Condit. Reinf. active minus inactive responses	0.9	1.2	1.3	1.2	-1.0	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.9	1.0	-0.8	-0.5
Condit. Reinf. active responses	0.5	0.8	0.9	0.9	-0.8	-0.9
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.4	0.3	0.0
Condit. Reinf. lever presses	2.2	3.1	3.5	-1.6	1.8	1.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.4	-0.3	-0.3
Conditioned reinforcement - actives	0.6	1.0	1.5	-1.2	1.0	-0.7
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.5	-0.2	-0.6
Conditioned locomotion	0.9	1.1	1.5	1.1	-0.8	-1.2
Patch foraging indifference point 0 sec	3.2	5.9	6.3	2.3	-2.4	-2.5
Patch foraging indifference point AUC	1.6	2.4	2.7	1.6	-1.6	-1.4
Delay disc. indifference point, 0s delay	0.7	0.8	1.0	-0.9	0.8	1.0
Delay disc. indifference point, 16s delay	0.6	0.6	1.7	0.3	-0.4	-1.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	0.7	-0.4	-0.0
Delay disc. indifference point, 24s delay	0.3	0.3	1.0	0.0	-0.1	-1.0
Delay disc. indifference point, 4s delay	0.3	0.4	0.6	-0.4	0.6	0.8
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.0	-0.0
Indifference point function ln k	0.2	0.3	0.5	-0.6	0.7	0.1
Indifference point function log k	0.2	0.3	0.5	-0.6	0.7	0.1
Patch foraging total patch changes 0 sec	3.1	5.8	6.2	2.3	-2.4	-2.5
Patch foraging total patch changes 12 sec	3.0	3.9	4.1	1.9	-2.0	-2.0
Patch foraging total patch changes 18 sec	2.9	4.4	4.9	2.0	-2.1	-2.2
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	0.8	-0.6	0.0
Patch foraging total patch changes 6 sec	1.7	2.6	3.3	1.8	-1.8	-1.2
Patch foraging time to switch 0 sec	0.8	1.7	2.1	-1.1	1.3	1.5
Patch foraging water rate 0 sec	1.4	2.9	3.0	1.6	-1.7	-1.7
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.5	-0.4	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.5	-0.2	-0.6
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	-0.1	-0.1
Patch foraging water rate 6 sec	0.7	1.0	1.3	1.1	-1.0	-0.9
Seeking ratio, delayed vs. immediate footshock	2.5	3.1	3.3	1.8	-1.8	-1.6
Distance traveled before self-admin	0.6	0.8	2.0	1.4	-0.7	0.1
Distance traveled after self-admin	0.1	0.1	0.2	0.5	-0.3	0.1
Extensor digitorum longus weight	0.6	2.4	2.6	-1.6	1.6	1.5
Bone: elastic displacement	1.5	1.8	1.9	1.3	-1.4	-1.4
Bone: elastic work	0.4	0.6	0.7	0.8	-0.8	-0.6
Bone: endosteal estimation	0.2	0.4	1.0	0.3	-0.4	-1.0
Bone: endosteal perimeter	0.4	0.9	1.8	0.6	-0.7	-1.3
Epididymis fat weight	2.4	8.3	10.5	2.7	-2.7	-3.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.4	-0.2
Delta time in open arm before/after self-admin	0.8	0.8	2.2	-0.0	0.3	1.5
Diff in mean of infusions in LGA sessions	0.7	0.8	1.3	-0.8	0.8	1.2
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.1	0.2
Extinction: sum of active levers before priming	0.7	0.7	1.2	-1.1	0.9	0.4
Active lever presses in extinction session 6	0.0	0.0	0.0	0.0	-0.1	-0.1
Bone: final force	0.8	1.3	1.6	-1.0	1.1	1.2
Bone: final moment	0.3	0.5	0.7	-0.6	0.7	0.8
Food consumed during 24 hour testing period	1.1	1.5	3.9	0.4	-0.7	-2.0
Glucose	1.6	2.5	2.8	-1.7	1.7	1.3
Heart weight	0.0	0.0	0.0	-0.1	0.2	0.2
Delay discount hyperbolic model param	0.0	0.0	0.0	0.2	-0.2	-0.1
Intermittent access intake day 1-15 change	0.9	1.8	3.1	-1.7	1.5	0.3
Intermittent access intake escalation	1.0	2.0	3.3	-1.8	1.6	0.5
Intermittent access intake escalation 2	0.7	0.8	1.5	-1.2	1.0	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.3	0.1	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	-0.2	0.4	0.3
Intermitt. access escalation Index	0.2	0.3	0.4	0.6	-0.6	-0.3
Intermittent access day 1 total infusions	0.2	0.3	0.9	-0.4	0.1	-0.9
Intermittent access day 15 total infusions	1.3	1.9	3.4	-1.9	1.5	-0.4
Intermittent access terminal intake (last 3 days)	2.1	2.7	4.7	-2.2	1.8	-0.1
Intermittent access total infusions	1.6	1.9	3.5	-1.9	1.5	-0.3
Intermittent access day 1 locomotion	1.4	1.8	2.5	1.1	-1.3	-1.6
Intermittent access day 15 total locomotion	0.2	0.4	0.7	0.5	-0.5	-0.8
Intermittent access total locomotion	0.1	0.1	0.4	0.2	-0.2	-0.6
Intermittent access standard deviation	0.2	0.4	0.5	0.5	-0.5	-0.7
Left kidney weight	1.3	6.2	7.2	-2.4	2.7	2.4
Right kidney weight	1.5	6.6	7.1	-2.4	2.7	2.6
Cocaine induced anxiety	2.0	2.9	3.8	2.0	-1.9	-1.2
Post-drug Anxiety	0.5	0.5	0.6	0.7	-0.7	-0.8
Baseline Anxiety	1.2	1.4	2.4	-1.5	1.4	0.2
Tail length	0.0	0.0	0.1	-0.0	-0.2	-0.3
Length with tail	0.1	0.6	0.7	0.8	-0.8	-0.7
Length without tail	0.6	1.8	1.9	1.4	-1.3	-1.4
Times rat made contact with spout	1.8	2.0	2.8	1.2	-1.4	-1.7
Lifetime Intake	1.3	1.6	3.0	-1.7	1.4	-0.3
Liver weight, left	0.2	0.3	0.5	0.7	-0.6	-0.2
Liver weight, right	0.5	0.9	1.1	0.8	-1.0	-1.0
Locomotor activity	2.2	3.5	4.9	2.2	-2.1	-1.1
Locomotor testing distance	1.8	3.2	4.2	2.0	-2.0	-1.2
Locomotor testing rearing	0.2	0.3	0.6	0.8	-0.7	0.0
Locomotion in novel chamber	2.2	2.8	3.6	1.9	-1.7	-1.4
Locomotion in novel chamber post-restriction	1.3	2.2	3.0	1.6	-1.7	-1.0
Fecal boli incidents, locomotor time 1	0.8	1.2	1.6	0.9	-1.3	-1.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	-0.7	0.8	0.4
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.5	0.2	-0.7	-0.5
Bouts of movement, locomotor time 1	0.1	0.2	0.4	0.1	-0.2	-0.6
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	0.1	-0.4
Rest time, locomotor task time 1	0.2	0.3	0.5	-0.5	0.4	0.7
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.5	-0.4	-0.7
Vertical activity count, locomotor time 1	0.8	1.9	3.2	1.1	-1.2	-1.8
Time >=10cm from walls, locomotor time 2	0.7	1.0	1.7	-0.9	0.6	1.3
Bouts of movement, locomotor time 2	0.5	0.8	1.2	-1.1	1.0	0.5
Total resting periods, locomotor time 2	0.6	1.0	1.5	-1.2	1.1	0.6
Rest time, locomotor task time 2	0.5	0.6	1.2	-1.1	0.8	0.3
Distance moved, locomotor task time 2	0.5	0.6	1.1	1.0	-0.8	-0.4
Vertical activity count, locomotor time 2	1.1	1.5	1.7	1.3	-1.2	-1.2
Light reinforcement 1	2.3	5.7	6.8	2.6	-2.4	-2.1
Light reinforcement 2	2.2	3.4	4.0	2.0	-1.9	-1.6
Bone: marrow area	0.2	0.4	1.0	0.2	-0.3	-1.0
Bone: maximum diameter	0.6	1.1	1.5	1.0	-0.9	-1.2
Bone: maximum force	0.3	0.5	0.9	-0.5	0.7	1.0
Bone: maximum moment	0.1	0.1	0.2	-0.1	0.3	0.5
Mean time between licks in bursts	0.0	0.1	0.2	0.2	-0.1	-0.4
Mean num. licks in bursts	0.0	0.0	0.1	-0.2	-0.1	-0.3
Cd content in liver	0.1	0.1	0.2	-0.1	0.3	0.5
Co content in liver	0.0	0.0	0.1	-0.3	0.2	0.0
Cu content in liver	0.7	0.9	1.2	-1.1	1.0	0.6
Fe content in liver	1.5	1.8	2.6	1.4	-1.6	-0.9
K content in liver	0.1	0.1	0.2	-0.5	0.3	-0.2
Mg content in liver	0.6	0.6	1.1	0.5	-0.7	-1.0
Mn content in liver	0.7	0.8	1.1	0.8	-0.8	-1.0
Na content in liver	0.0	0.0	0.0	-0.2	0.1	0.1
Rb content in liver	0.2	0.2	0.3	-0.6	0.5	0.1
Se content in liver	0.0	0.0	0.0	-0.2	0.2	0.1
Sr content in liver	1.4	1.2	1.5	1.0	-1.0	-1.2
Zn content in liver	1.4	1.5	2.3	-1.5	1.4	0.6
Bone: minimum diameter	0.1	0.3	0.3	0.5	-0.5	-0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.6	-0.4	-0.5
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.6	0.4	0.7
Total zone transitions, hab. session 1	0.9	1.2	1.3	1.1	-1.1	-1.1
Total locomotion distance, hab. session 1	1.0	1.5	1.8	1.2	-1.3	-1.1
Locomotion velocity, hab. session 1	1.4	2.0	2.3	1.3	-1.5	-1.4
Time in familiar zone, hab. session 2	0.8	0.8	1.2	1.1	-0.9	-0.7
Time in novel zone, hab. session 2	5.0	5.1	5.5	-2.3	2.2	2.3
Total zone transitions, hab. session 2	2.1	2.6	3.1	1.7	-1.8	-1.3
Total locomotion distance, hab. session 2	1.3	1.7	1.9	1.3	-1.4	-1.2
Locomotion velocity, hab. session 2	1.2	1.6	1.9	1.3	-1.4	-1.2
Novel to familiar place preference ratio	2.4	2.6	2.8	-1.6	1.7	1.6
Novelty place preference	3.8	4.1	4.4	-2.0	2.0	2.1
Time in novel zone, NPP test	3.5	3.8	4.0	-1.9	2.0	2.0
Total zone transitions, NPP test	1.9	2.7	2.8	1.6	-1.7	-1.6
Total locomotion distance, NPP test	0.9	1.3	1.6	1.1	-1.3	-1.0
Locomotion velocity, NPP test	0.8	1.1	1.4	1.0	-1.2	-0.9
Intraocular pressure	0.5	0.7	1.1	-0.5	0.8	1.1
Delta distance traveled before/after self-admin	0.5	0.5	0.6	-0.8	0.7	0.6
Delta ambulatory time before/after self-admin	0.7	0.8	1.3	-1.1	0.9	0.6
Parametrial fat weight	7.0	16.4	18.2	4.3	-4.0	-3.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.1	-0.1	-0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.7	0.7	0.5
Pavlov. Cond. change in total contacts	0.8	0.8	1.1	-0.8	0.9	1.0
Pavlov. Cond. index score	0.2	0.3	0.3	-0.4	0.5	0.6
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.3	0.4	0.5
Pavlov. Cond. lever contacts	0.5	0.6	0.9	-0.7	0.7	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.8	-0.8	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.4	-0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	-0.5	0.6	0.6
Pavlov. Cond. response bias	0.2	0.2	0.2	-0.5	0.5	0.5
Pavlov. Cond. lever latency	1.2	1.6	1.7	1.3	-1.3	-1.3
Pavlov. Cond. magazine entry latency	3.3	4.0	4.0	-2.0	2.0	2.0
Pavlov. Cond. change in total contacts	1.6	2.6	3.0	-1.5	1.6	1.7
Pavlov. Cond. index score	3.2	4.3	4.4	-2.1	2.1	2.1
Pavlov. Cond. latency score	3.2	4.2	4.4	-2.0	2.1	2.0
Pavlov. Cond. lever contacts	1.4	2.0	2.1	-1.4	1.4	1.3
Pavlov. Cond. magazine entry number	5.3	6.5	6.7	2.5	-2.6	-2.6
Pavlov. Cond. intertrial magazine entries	4.4	6.7	7.2	2.6	-2.7	-2.4
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.8	5.0	-2.2	2.2	2.1
Pavlov. Cond. response bias	2.9	3.9	4.0	-2.0	2.0	2.0
Time in closed arm before self-admin	3.8	4.9	7.0	1.9	-2.0	-2.7
Time in closed arm after self-admin	3.1	3.3	3.8	1.9	-1.8	-1.7
Time in open arm before self-admin	1.5	1.6	1.6	-1.3	1.3	1.2
Time in open arm after self-admin	1.3	1.4	3.0	-0.7	0.9	1.7
Bone: periosteal estimation	0.3	0.6	0.7	0.8	-0.8	-0.9
Bone: periosteal perimeter	0.8	1.4	1.5	1.2	-1.2	-1.2
Bone: post-yield work	0.5	0.8	1.1	1.1	-0.8	-0.7
Progressive ratio test 1 active lever presses	2.1	2.6	4.5	-2.1	1.8	0.4
Progressive ratio test 1 breakpoint	1.9	2.3	4.0	-2.0	1.7	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.5	0.2	-0.3
Progressive ratio test 2 active lever presses	1.7	1.9	3.8	-1.9	1.4	-0.3
Progressive ratio test 2 breakpoint	1.7	2.0	3.9	-2.0	1.4	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.5	0.4	-0.3
Incentive Sensitization - Responses	0.5	0.8	1.6	-1.3	0.7	-0.4
Incentive Sensitization - Breakpoint	0.7	0.9	1.8	-1.3	0.8	-0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	-0.4	0.6	0.9
Progressive ratio	0.5	0.7	1.9	0.5	0.0	1.4
Food seeking constrained by brief footshock	2.0	2.5	3.9	-1.3	1.4	2.0
Seeking ratio, punishment vs. effort	0.5	0.7	1.4	-1.2	0.9	0.2
Retroperitoneal fat weight	6.4	27.4	30.6	5.5	-5.3	-4.9
Reaction time number correct	0.8	1.5	2.3	-1.5	1.4	0.6
Reaction time mean minus median	0.8	2.0	3.8	-1.0	1.2	1.9
Reaction time mean minus median AUC	0.6	1.5	2.9	-0.8	1.0	1.7
Reaction time num false alarms	0.1	0.1	0.2	-0.4	0.4	0.1
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.1	-0.1	-0.3
Reaction time trials correct on left	0.8	1.5	2.3	-1.5	1.4	0.6
Reaction time trials on left	0.8	1.6	2.4	-1.6	1.4	0.6
Reaction time mean	0.5	0.9	2.5	0.2	0.3	1.6
Reaction time mean AUC	0.7	1.2	3.1	-0.1	0.6	1.8
Median of all reaction times	0.3	0.5	1.2	0.5	0.0	1.1
Reaction time omissions	0.2	0.3	0.6	0.2	-0.5	-0.8
Reaction time false alarm rate	0.3	0.4	0.5	0.7	-0.7	-0.6
Reaction time premature initiation rate	1.4	1.9	2.4	-1.3	1.3	1.5
Reaction time premature initiations	2.3	4.1	4.5	-2.1	2.0	1.9
Std. dev. reaction times	0.7	1.2	3.3	-0.2	0.6	1.8
Reaction time trials completed	0.8	1.6	2.4	-1.6	1.4	0.6
Reaction time trials AUC	0.9	1.7	2.5	-1.6	1.4	0.7
Run reversals in cocaine runway, females	1.7	1.7	1.9	1.2	-1.4	-1.3
Run reversals in cocaine runway, males	0.6	0.6	0.9	0.4	-0.8	-0.9
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.4	0.6	0.5
Latency to leave start box in cocaine runway, F	1.3	1.5	1.9	-1.4	1.3	1.0
Latency to leave start box in cocaine runway, M	1.1	1.0	2.1	1.5	-0.9	-0.5
Std. dev. time between licks in bursts	2.1	2.8	2.9	1.7	-1.7	-1.6
Total sessions with >9 infusions	1.0	1.2	2.4	-1.5	1.1	0.0
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.2
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.5	-0.5	0.0
Short access day 1 total infusions	0.4	0.5	0.8	-0.9	0.4	-0.7
Short access day 10 total infusions	0.4	0.5	0.7	-0.8	0.5	-0.8
Short access total infusions	1.3	1.6	3.1	-1.8	1.3	-0.1
Short access day 1 locomotion	0.2	0.2	0.5	-0.7	0.3	-0.3
Short access day 10 total locomotion	1.3	2.4	3.0	1.7	-1.6	-1.3
Short access total locomotion	0.4	0.4	0.7	0.6	-0.6	-0.8
One hour access (0.3 mA shock)	0.8	1.0	1.7	-1.3	1.0	-0.5
Compulsive drug intake	0.1	0.2	0.3	0.5	-0.4	0.2
One hour access (shock baseline)	0.8	1.2	2.2	-1.5	1.1	-0.6
Social response proportion	0.4	0.4	0.6	-0.8	0.7	-0.4
Social responses	0.1	0.2	0.5	0.1	-0.0	-0.7
Social time	0.2	0.2	0.7	-0.2	0.0	-0.8
Soleus weight	0.2	0.5	0.8	0.9	-0.8	-0.5
Bone: stiffness	2.8	4.6	5.1	-2.0	2.3	2.2
Tibialis anterior weight	0.1	0.5	0.6	-0.8	0.7	0.7
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.7	-0.8	0.6	0.4
Time to tail flick, vehicle, after self-admin	2.2	2.8	6.6	0.8	-1.2	-2.6
Time to tail flick, test, before self-admin	4.8	4.9	7.9	1.8	-1.9	-2.8
Time to tail flick, test, after self-admin	0.9	0.9	2.6	0.3	-0.4	-1.6
Delta time to tail flick, vehicle, before/after SA	2.1	2.0	4.2	0.8	-1.1	-2.1
Delta time to tail flick, test, before/after SA	1.0	1.1	1.2	-1.1	1.0	0.9
Tibia length	0.0	0.1	0.4	-0.0	0.1	0.6
Ambulatory time before self-admin	1.0	1.4	2.7	1.6	-1.1	-0.6
Ambulatory time after self-admin	0.3	0.3	0.6	0.8	-0.5	-0.2
Bone: tissue strength	0.3	0.3	0.4	-0.6	0.6	0.3
Total heroin consumption	1.0	1.2	1.6	-1.3	1.1	0.9
Bone: trabecular number	0.2	0.4	0.7	0.9	-0.6	-0.0
Bone: trabecular spacing	0.2	0.3	0.7	0.2	-0.3	-0.8
Bone: trabecular thickness	0.9	1.1	2.2	-0.7	0.8	1.5
Bone: trabecular tissue density	0.8	1.2	1.4	-1.0	1.0	1.2
Water consumed over 24 hours	0.5	0.6	1.2	0.6	-0.7	-1.1
Number of responses in last shaping day	0.7	0.7	0.9	-0.6	0.9	1.0