Exoc1l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Exoc1l 0.19 0.11 8.1e-03 0.01 0.04 0.03 0.01 1.9e-01 4.4e-02 8.0e-02 1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density1.62.72.7-1.6
Area under the delay curve1.21.31.3-1.1
BMI with tail0.00.10.10.2
BMI without tail0.20.30.3-0.6
Body weight0.62.62.6-1.6
Weight adjusted by age0.50.60.6-0.7
Bone surface0.61.11.1-1.1
Bone volume0.30.50.5-0.7
Breakpoint value in progressive ratio session0.30.30.30.5
Number of licking bursts2.53.03.0-1.7
Context. condit. distance diff. score1.11.31.31.1
Locomotion velocity, session 10.20.20.2-0.4
Locomotion distance, session 10.10.10.10.4
Locomotion velocity, session 20.10.10.10.4
Locomotion distance, session 20.10.10.10.4
Locomotion velocity, session 30.20.20.20.4
Locomotion distance, session 31.31.41.41.2
Stereotopy head waving bouts, day 32.73.23.21.8
Stereotopy head waving duration, day 311.914.214.23.8
Locomotion velocity, session 70.00.00.0-0.2
Locomotion distance, session 71.82.22.21.5
Stereotopy head waving bouts, day 74.34.84.82.2
Stereotopy head waving duration, day 70.60.70.7-0.8
Locomotion velocity, session 80.00.00.0-0.2
Locomotion distance, session 81.31.91.91.4
Degree of sensitization distance0.70.70.70.8
Degree of sensitization stereotypy1.41.51.5-1.2
Conditioned locomotion0.00.00.00.1
Cocaine response after cond. corrected0.20.20.20.4
Cocaine response after cond. not corrected0.00.00.00.2
Cocaine response before conditioning0.00.00.0-0.1
Saline control response3.54.54.5-2.1
Bone: connectivity density1.52.42.4-1.6
Bone: cortical apparent density1.21.61.6-1.3
Bone: cortical area2.53.83.8-1.9
Bone: cortical porosity0.70.80.8-0.9
Bone: cortical porosity2.12.32.3-1.5
Bone: cortical thickness3.45.65.6-2.4
Bone: cortical thickness1.11.21.2-1.1
Bone: cortical tissue density1.01.41.4-1.2
Condit. Reinf. active minus inactive responses2.83.13.11.8
Condit. Reinf. active-inactive response ratio2.12.32.31.5
Condit. Reinf. active responses2.83.43.41.8
Condit. Reinf. inactive responses0.10.20.20.4
Incentive salience index mean0.81.01.01.0
Condit. Reinf. lever presses0.30.40.4-0.6
Condit. Reinf. active minus inactive responses2.32.92.9-1.7
Condit. Reinf. active-inactive response ratio1.51.61.6-1.3
Condit. Reinf. active responses0.81.11.1-1.1
Condit. Reinf. inactive responses0.10.20.20.4
Condit. Reinf. lever presses1.72.32.3-1.5
Condit. Reinf. lever reinforcers received0.70.90.9-1.0
Conditioned reinforcement - actives0.00.00.0-0.1
Conditioned reinforcement - inactives0.91.01.01.0
Conditioned locomotion0.30.40.4-0.6
Patch foraging indifference point 0 sec0.20.30.30.6
Patch foraging indifference point AUC4.85.55.52.4
Delay disc. indifference point, 0s delay0.70.80.8-0.9
Delay disc. indifference point, 16s delay1.61.61.6-1.3
Delay disc. indifference point, 2s delay0.30.40.4-0.6
Delay disc. indifference point, 24s delay0.10.10.1-0.2
Delay disc. indifference point, 4s delay2.12.22.2-1.5
Delay disc. indifference point, 8s delay0.20.20.2-0.4
Indifference point function ln k0.91.31.3-1.2
Indifference point function log k0.91.31.3-1.2
Patch foraging total patch changes 0 sec0.30.40.40.7
Patch foraging total patch changes 12 sec0.10.10.10.4
Patch foraging total patch changes 18 sec0.60.80.80.9
Patch foraging total patch changes 24 sec0.91.21.21.1
Patch foraging total patch changes 6 sec1.42.12.11.5
Patch foraging time to switch 0 sec4.46.86.8-2.6
Patch foraging water rate 0 sec1.22.02.01.4
Patch foraging water rate 12 sec0.20.30.30.5
Patch foraging water rate 18 sec1.82.42.41.5
Patch foraging water rate 24 sec0.30.50.50.7
Patch foraging water rate 6 sec3.04.44.42.1
Seeking ratio, delayed vs. immediate footshock0.60.70.70.8
Distance traveled before self-admin2.22.32.3-1.5
Distance traveled after self-admin0.91.01.0-1.0
Extensor digitorum longus weight4.317.017.0-4.1
Bone: elastic displacement0.00.10.1-0.2
Bone: elastic work0.40.50.5-0.7
Bone: endosteal estimation0.10.20.2-0.4
Bone: endosteal perimeter0.00.00.0-0.2
Epididymis fat weight0.10.20.20.4
Delta time in closed arm before/after self-admin1.81.81.81.3
Delta time in open arm before/after self-admin1.91.81.8-1.3
Diff in mean of infusions in LGA sessions1.31.51.51.2
Delay discount exponential model param1.31.31.31.2
Extinction: sum of active levers before priming3.02.92.91.7
Active lever presses in extinction session 60.70.70.70.8
Bone: final force3.86.16.1-2.5
Bone: final moment4.26.86.8-2.6
Food consumed during 24 hour testing period1.41.71.71.3
Glucose0.00.00.00.2
Heart weight0.60.80.80.9
Delay discount hyperbolic model param1.31.31.31.2
Intermittent access intake day 1-15 change0.30.30.3-0.5
Intermittent access intake escalation0.20.20.2-0.4
Intermittent access intake escalation 20.90.90.9-0.9
Intermitt. access day 1 inactive lever presses4.34.64.62.2
Intermitt. access day 15 inactive lever presses2.02.22.21.5
Intermitt. access escalation Index0.00.00.0-0.0
Intermittent access day 1 total infusions0.40.50.50.7
Intermittent access day 15 total infusions0.00.10.10.2
Intermittent access terminal intake (last 3 days)0.00.00.00.2
Intermittent access total infusions0.00.00.0-0.1
Intermittent access day 1 locomotion0.60.60.60.8
Intermittent access day 15 total locomotion0.20.20.20.5
Intermittent access total locomotion0.00.00.0-0.1
Intermittent access standard deviation1.51.61.6-1.3
Left kidney weight2.56.96.9-2.6
Right kidney weight0.30.80.8-0.9
Cocaine induced anxiety0.50.60.6-0.8
Post-drug Anxiety0.10.10.1-0.3
Baseline Anxiety0.20.20.20.5
Tail length1.33.83.8-2.0
Length with tail1.03.83.8-1.9
Length without tail0.51.11.1-1.0
Times rat made contact with spout0.50.50.5-0.7
Lifetime Intake0.10.10.1-0.3
Liver weight, left0.40.70.70.8
Liver weight, right0.00.00.00.1
Locomotor activity1.32.12.11.4
Locomotor testing distance0.10.20.20.4
Locomotor testing rearing0.10.10.10.3
Locomotion in novel chamber0.00.10.1-0.2
Locomotion in novel chamber post-restriction0.00.00.00.1
Fecal boli incidents, locomotor time 10.30.30.30.5
Change in fecal boli incidents, locomotor task0.10.10.1-0.4
Time >=10cm from walls, locomotor time 11.81.81.8-1.3
Bouts of movement, locomotor time 10.30.40.40.6
Total resting periods, locomotor time 10.10.10.10.3
Rest time, locomotor task time 12.22.42.41.5
Distance moved, locomotor task time 10.91.01.0-1.0
Vertical activity count, locomotor time 11.92.02.0-1.4
Time >=10cm from walls, locomotor time 20.00.00.0-0.1
Bouts of movement, locomotor time 22.93.13.11.8
Total resting periods, locomotor time 23.63.93.92.0
Rest time, locomotor task time 23.84.44.42.1
Distance moved, locomotor task time 23.64.14.1-2.0
Vertical activity count, locomotor time 21.71.91.9-1.4
Light reinforcement 10.00.00.00.1
Light reinforcement 20.50.60.60.8
Bone: marrow area0.10.30.3-0.5
Bone: maximum diameter0.10.10.1-0.4
Bone: maximum force3.05.25.2-2.3
Bone: maximum moment3.45.95.9-2.4
Mean time between licks in bursts2.33.33.31.8
Mean num. licks in bursts1.92.22.21.5
Cd content in liver2.42.62.61.6
Co content in liver3.54.14.1-2.0
Cu content in liver0.91.11.11.1
Fe content in liver4.25.05.02.2
K content in liver0.10.10.1-0.2
Mg content in liver1.11.11.11.1
Mn content in liver2.73.03.0-1.7
Na content in liver0.91.01.01.0
Rb content in liver0.00.00.0-0.0
Se content in liver0.81.01.01.0
Sr content in liver0.00.00.0-0.1
Zn content in liver1.71.81.81.4
Bone: minimum diameter0.61.21.2-1.1
Time in familiar zone, hab. session 10.00.00.0-0.2
Time in novel zone, hab. session 10.30.30.30.5
Total zone transitions, hab. session 10.30.40.4-0.6
Total locomotion distance, hab. session 119.928.328.35.3
Locomotion velocity, hab. session 115.722.322.34.7
Time in familiar zone, hab. session 20.91.01.01.0
Time in novel zone, hab. session 20.70.70.7-0.8
Total zone transitions, hab. session 21.92.42.4-1.6
Total locomotion distance, hab. session 28.311.011.03.3
Locomotion velocity, hab. session 27.810.510.53.2
Novel to familiar place preference ratio0.60.70.70.8
Novelty place preference0.30.30.30.5
Time in novel zone, NPP test0.20.20.20.4
Total zone transitions, NPP test0.70.90.9-1.0
Total locomotion distance, NPP test10.514.414.43.8
Locomotion velocity, NPP test10.815.315.33.9
Intraocular pressure2.63.73.71.9
Delta distance traveled before/after self-admin0.00.00.0-0.0
Delta ambulatory time before/after self-admin0.20.20.20.5
Parametrial fat weight1.63.13.11.7
Pavlov. Cond. lever latency0.20.30.30.5
Pavlov. Cond. magazine entry latency0.50.60.60.8
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.20.20.20.5
Pavlov. Cond. latency score0.00.10.10.2
Pavlov. Cond. lever contacts0.20.20.2-0.5
Pavlov. Cond. magazine entry number1.41.71.7-1.3
Pavlov. Cond. intertrial magazine entries0.40.40.40.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.4
Pavlov. Cond. response bias0.00.00.00.2
Pavlov. Cond. lever latency0.00.00.00.1
Pavlov. Cond. magazine entry latency0.30.40.4-0.6
Pavlov. Cond. change in total contacts0.00.10.1-0.3
Pavlov. Cond. index score0.00.10.1-0.2
Pavlov. Cond. latency score0.10.10.1-0.3
Pavlov. Cond. lever contacts0.10.10.1-0.4
Pavlov. Cond. magazine entry number0.00.00.00.2
Pavlov. Cond. intertrial magazine entries0.70.90.91.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.2
Pavlov. Cond. response bias0.00.00.0-0.2
Time in closed arm before self-admin2.02.32.3-1.5
Time in closed arm after self-admin0.00.00.0-0.1
Time in open arm before self-admin2.52.72.71.6
Time in open arm after self-admin0.40.40.40.7
Bone: periosteal estimation1.12.32.3-1.5
Bone: periosteal perimeter0.20.30.3-0.6
Bone: post-yield work0.00.00.00.2
Progressive ratio test 1 active lever presses0.00.00.00.1
Progressive ratio test 1 breakpoint0.10.10.10.2
Progressive ratio test 1 inactive lever presses2.32.62.61.6
Progressive ratio test 2 active lever presses0.10.10.1-0.3
Progressive ratio test 2 breakpoint0.10.10.1-0.4
Progressive ratio test 2 inactive lever presses1.41.71.71.3
Incentive Sensitization - Responses0.70.70.7-0.8
Incentive Sensitization - Breakpoint0.60.60.6-0.8
Sum of active levers in priming session hrs 5-61.51.51.5-1.2
Progressive ratio0.40.50.5-0.7
Food seeking constrained by brief footshock2.02.42.4-1.6
Seeking ratio, punishment vs. effort0.00.00.00.0
Retroperitoneal fat weight0.10.30.30.6
Reaction time number correct1.01.51.5-1.2
Reaction time mean minus median0.30.30.3-0.6
Reaction time mean minus median AUC0.40.50.5-0.7
Reaction time num false alarms0.00.10.10.2
Reaction time num false alarms AUC0.00.00.0-0.0
Reaction time trials correct on left1.01.51.5-1.2
Reaction time trials on left1.21.71.7-1.3
Reaction time mean2.23.13.1-1.8
Reaction time mean AUC2.33.03.0-1.7
Median of all reaction times2.73.73.7-1.9
Reaction time omissions4.46.06.0-2.4
Reaction time false alarm rate0.50.80.80.9
Reaction time premature initiation rate0.10.10.1-0.4
Reaction time premature initiations0.81.11.1-1.0
Std. dev. reaction times1.42.02.0-1.4
Reaction time trials completed1.21.71.7-1.3
Reaction time trials AUC1.31.91.9-1.4
Run reversals in cocaine runway, females0.10.10.1-0.4
Run reversals in cocaine runway, males0.10.10.1-0.3
Latency to leave start box in cocaine runway0.00.00.00.1
Latency to leave start box in cocaine runway, F0.40.40.40.7
Latency to leave start box in cocaine runway, M0.10.10.10.3
Std. dev. time between licks in bursts1.41.61.61.3
Total sessions with >9 infusions0.40.40.40.6
Short access day 1 total inactive lever presses3.84.34.32.1
Short access day 10 total inactive lever presses1.51.71.71.3
Short access day 1 total infusions0.00.00.00.1
Short access day 10 total infusions0.00.00.00.2
Short access total infusions0.00.00.00.0
Short access day 1 locomotion0.00.00.00.2
Short access day 10 total locomotion0.10.10.10.3
Short access total locomotion0.10.10.10.4
One hour access (0.3 mA shock)0.00.00.0-0.0
Compulsive drug intake1.01.01.01.0
One hour access (shock baseline)1.01.21.2-1.1
Social response proportion3.63.93.9-2.0
Social responses1.41.81.8-1.3
Social time4.55.95.9-2.4
Soleus weight0.20.70.7-0.8
Bone: stiffness1.72.62.6-1.6
Tibialis anterior weight1.24.34.3-2.1
Time to tail flick, vehicle, before self-admin0.40.40.40.6
Time to tail flick, vehicle, after self-admin1.41.41.41.2
Time to tail flick, test, before self-admin1.61.61.61.3
Time to tail flick, test, after self-admin0.00.00.00.2
Delta time to tail flick, vehicle, before/after SA1.01.01.0-1.0
Delta time to tail flick, test, before/after SA0.30.30.3-0.5
Tibia length1.33.73.7-1.9
Ambulatory time before self-admin2.32.42.4-1.6
Ambulatory time after self-admin1.81.91.9-1.4
Bone: tissue strength0.90.90.9-0.9
Total heroin consumption0.60.70.70.8
Bone: trabecular number0.60.90.9-0.9
Bone: trabecular spacing0.00.00.00.1
Bone: trabecular thickness0.20.20.20.5
Bone: trabecular tissue density0.00.00.00.0
Water consumed over 24 hours0.00.00.00.0
Number of responses in last shaping day2.82.92.91.7