Hub : Genes

Evi2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Evi2a 0.13 0.12 9.4e-03 0.08 0.08 0.08 0.08 5.3e-03 6.3e-03 5.2e-03 7.3e-03
2 Liver gene expression Evi2a 0.03 0.03 9.2e-04 0.01 0.01 0.01 0.01 1.3e-02 8.7e-03 2.7e-02 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.64.45.11.9-2.3
Area under the delay curve0.10.10.30.10.5
BMI with tail0.41.32.10.7-1.4
BMI without tail0.41.31.71.0-1.3
Body weight2.611.612.83.2-3.6
Weight adjusted by age0.50.81.3-0.61.1
Bone surface0.71.21.41.0-1.2
Bone volume1.01.82.11.3-1.4
Breakpoint value in progressive ratio session1.92.32.71.4-1.6
Number of licking bursts0.50.80.9-0.80.9
Context. condit. distance diff. score0.30.30.50.4-0.7
Locomotion velocity, session 12.62.82.91.6-1.7
Locomotion distance, session 10.10.10.10.4-0.2
Locomotion velocity, session 20.00.00.10.1-0.2
Locomotion distance, session 20.50.70.70.8-0.8
Locomotion velocity, session 32.73.13.4-1.71.8
Locomotion distance, session 30.50.50.6-0.60.8
Stereotopy head waving bouts, day 30.00.00.1-0.2-0.0
Stereotopy head waving duration, day 30.20.30.3-0.50.5
Locomotion velocity, session 70.00.00.00.10.1
Locomotion distance, session 70.00.00.00.1-0.0
Stereotopy head waving bouts, day 71.01.11.21.0-1.1
Stereotopy head waving duration, day 70.50.60.70.7-0.8
Locomotion velocity, session 80.10.10.10.3-0.3
Locomotion distance, session 80.20.20.40.3-0.6
Degree of sensitization distance1.91.92.11.3-1.4
Degree of sensitization stereotypy1.31.41.41.2-1.2
Conditioned locomotion3.43.94.2-2.01.9
Cocaine response after cond. corrected0.60.70.80.8-0.9
Cocaine response after cond. not corrected1.21.41.71.1-1.3
Cocaine response before conditioning0.20.20.30.3-0.6
Saline control response0.10.10.1-0.40.2
Bone: connectivity density2.94.65.22.0-2.3
Bone: cortical apparent density0.20.30.4-0.50.6
Bone: cortical area2.13.23.4-1.71.9
Bone: cortical porosity0.10.10.1-0.20.3
Bone: cortical porosity0.20.20.2-0.40.5
Bone: cortical thickness3.25.45.4-2.32.3
Bone: cortical thickness0.40.40.5-0.60.7
Bone: cortical tissue density0.10.10.2-0.30.4
Condit. Reinf. active minus inactive responses0.40.40.7-0.30.8
Condit. Reinf. active-inactive response ratio0.30.30.5-0.40.7
Condit. Reinf. active responses0.00.00.0-0.20.2
Condit. Reinf. inactive responses0.00.10.1-0.0-0.3
Incentive salience index mean0.30.30.5-0.40.7
Condit. Reinf. lever presses0.00.00.10.1-0.3
Condit. Reinf. active minus inactive responses0.40.50.7-0.80.6
Condit. Reinf. active-inactive response ratio0.00.00.1-0.30.0
Condit. Reinf. active responses0.50.70.9-0.90.7
Condit. Reinf. inactive responses0.50.60.7-0.70.8
Condit. Reinf. lever presses1.11.51.8-1.11.4
Condit. Reinf. lever reinforcers received0.71.01.1-1.10.9
Conditioned reinforcement - actives0.20.30.5-0.7-0.4
Conditioned reinforcement - inactives0.50.71.3-1.10.2
Conditioned locomotion0.81.02.0-1.4-0.0
Patch foraging indifference point 0 sec0.10.30.5-0.10.7
Patch foraging indifference point AUC2.23.13.6-1.91.6
Delay disc. indifference point, 0s delay0.70.80.9-0.81.0
Delay disc. indifference point, 16s delay0.10.10.10.4-0.1
Delay disc. indifference point, 2s delay0.80.91.1-0.81.1
Delay disc. indifference point, 24s delay0.00.00.10.20.1
Delay disc. indifference point, 4s delay1.01.11.71.3-0.6
Delay disc. indifference point, 8s delay0.20.30.60.8-0.0
Indifference point function ln k3.15.47.92.8-1.7
Indifference point function log k3.15.47.92.8-1.7
Patch foraging total patch changes 0 sec0.10.20.5-0.10.7
Patch foraging total patch changes 12 sec0.20.30.3-0.50.5
Patch foraging total patch changes 18 sec1.11.71.7-1.31.3
Patch foraging total patch changes 24 sec1.01.71.8-1.31.3
Patch foraging total patch changes 6 sec2.74.24.7-1.92.2
Patch foraging time to switch 0 sec0.51.11.90.5-1.4
Patch foraging water rate 0 sec0.91.92.8-1.01.7
Patch foraging water rate 12 sec0.51.01.91.4-0.5
Patch foraging water rate 18 sec1.42.23.11.8-1.1
Patch foraging water rate 24 sec0.10.20.20.40.4
Patch foraging water rate 6 sec0.20.40.7-0.20.8
Seeking ratio, delayed vs. immediate footshock1.82.22.6-1.41.6
Distance traveled before self-admin1.21.52.4-0.81.6
Distance traveled after self-admin0.10.20.3-0.50.2
Extensor digitorum longus weight0.20.70.80.7-0.9
Bone: elastic displacement2.02.32.7-1.41.6
Bone: elastic work7.910.310.8-3.13.3
Bone: endosteal estimation0.00.00.00.10.2
Bone: endosteal perimeter0.20.50.70.8-0.5
Epididymis fat weight9.231.432.05.7-5.6
Delta time in closed arm before/after self-admin0.40.40.8-0.20.9
Delta time in open arm before/after self-admin2.12.13.40.9-1.8
Diff in mean of infusions in LGA sessions1.01.32.10.6-1.5
Delay discount exponential model param0.10.10.1-0.3-0.3
Extinction: sum of active levers before priming0.60.71.00.6-1.0
Active lever presses in extinction session 60.10.10.10.1-0.3
Bone: final force0.91.51.6-1.31.2
Bone: final moment0.81.41.5-1.21.1
Food consumed during 24 hour testing period0.30.40.4-0.60.6
Glucose1.62.52.6-1.61.6
Heart weight0.71.11.31.1-1.0
Delay discount hyperbolic model param0.10.20.3-0.1-0.6
Intermittent access intake day 1-15 change0.51.01.0-1.01.0
Intermittent access intake escalation0.40.91.0-1.00.9
Intermittent access intake escalation 21.01.11.4-0.91.2
Intermitt. access day 1 inactive lever presses0.20.81.0-0.81.0
Intermitt. access day 15 inactive lever presses1.53.04.1-2.01.4
Intermitt. access escalation Index2.12.93.91.4-2.0
Intermittent access day 1 total infusions0.10.20.4-0.0-0.6
Intermittent access day 15 total infusions0.10.20.3-0.6-0.1
Intermittent access terminal intake (last 3 days)0.20.30.60.1-0.8
Intermittent access total infusions0.00.00.1-0.3-0.1
Intermittent access day 1 locomotion0.50.61.1-1.00.3
Intermittent access day 15 total locomotion0.40.81.3-1.10.6
Intermittent access total locomotion0.50.61.0-1.00.5
Intermittent access standard deviation0.71.42.0-1.40.9
Left kidney weight0.10.30.60.3-0.8
Right kidney weight0.10.50.90.4-0.9
Cocaine induced anxiety0.20.30.40.6-0.5
Post-drug Anxiety1.71.92.31.2-1.5
Baseline Anxiety0.20.30.4-0.6-0.3
Tail length0.72.73.11.8-1.5
Length with tail2.29.711.33.4-2.8
Length without tail1.65.15.52.4-2.1
Times rat made contact with spout0.00.00.10.30.1
Lifetime Intake0.10.10.2-0.2-0.5
Liver weight, left6.310.412.03.0-3.5
Liver weight, right6.411.212.13.2-3.5
Locomotor activity0.10.10.10.3-0.2
Locomotor testing distance0.00.00.00.1-0.0
Locomotor testing rearing0.10.30.4-0.60.4
Locomotion in novel chamber1.62.02.6-1.21.6
Locomotion in novel chamber post-restriction1.11.82.81.7-0.9
Fecal boli incidents, locomotor time 10.00.10.1-0.3-0.3
Change in fecal boli incidents, locomotor task0.40.40.70.9-0.0
Time >=10cm from walls, locomotor time 11.71.82.6-1.61.0
Bouts of movement, locomotor time 12.02.32.8-1.71.3
Total resting periods, locomotor time 12.22.43.1-1.81.3
Rest time, locomotor task time 10.70.91.0-1.00.9
Distance moved, locomotor task time 10.40.50.70.8-0.6
Vertical activity count, locomotor time 10.51.31.41.2-1.1
Time >=10cm from walls, locomotor time 21.01.42.2-1.50.8
Bouts of movement, locomotor time 20.10.20.3-0.50.4
Total resting periods, locomotor time 20.10.30.3-0.60.4
Rest time, locomotor task time 20.91.11.1-1.01.1
Distance moved, locomotor task time 20.50.60.80.7-0.9
Vertical activity count, locomotor time 20.81.11.80.6-1.3
Light reinforcement 10.30.60.80.9-0.7
Light reinforcement 20.10.20.20.5-0.4
Bone: marrow area0.00.00.10.00.2
Bone: maximum diameter0.50.91.2-0.71.1
Bone: maximum force1.62.93.1-1.81.6
Bone: maximum moment1.52.72.9-1.71.6
Mean time between licks in bursts0.00.10.2-0.4-0.2
Mean num. licks in bursts0.50.80.91.0-0.9
Cd content in liver0.00.00.00.20.2
Co content in liver0.50.60.8-0.60.9
Cu content in liver1.61.92.0-1.41.4
Fe content in liver2.73.33.61.7-1.9
K content in liver0.20.10.20.3-0.4
Mg content in liver0.30.30.3-0.50.5
Mn content in liver0.30.40.4-0.60.7
Na content in liver1.41.51.71.1-1.3
Rb content in liver0.10.10.2-0.50.2
Se content in liver1.21.41.8-1.41.0
Sr content in liver0.10.10.10.3-0.3
Zn content in liver0.40.40.60.6-0.8
Bone: minimum diameter0.00.00.0-0.10.2
Time in familiar zone, hab. session 10.10.10.1-0.30.3
Time in novel zone, hab. session 10.10.10.10.2-0.3
Total zone transitions, hab. session 10.00.00.1-0.20.0
Total locomotion distance, hab. session 10.10.10.1-0.40.1
Locomotion velocity, hab. session 10.30.40.4-0.70.5
Time in familiar zone, hab. session 20.00.00.00.0-0.0
Time in novel zone, hab. session 20.10.10.2-0.40.4
Total zone transitions, hab. session 20.10.10.20.2-0.5
Total locomotion distance, hab. session 20.30.40.6-0.80.5
Locomotion velocity, hab. session 20.30.40.6-0.80.5
Novel to familiar place preference ratio0.20.20.20.4-0.4
Novelty place preference0.50.50.60.8-0.7
Time in novel zone, NPP test0.60.60.70.8-0.8
Total zone transitions, NPP test0.00.00.0-0.1-0.1
Total locomotion distance, NPP test1.01.31.3-1.21.2
Locomotion velocity, NPP test1.21.71.7-1.31.3
Intraocular pressure1.92.73.6-1.41.9
Delta distance traveled before/after self-admin0.70.71.30.3-1.2
Delta ambulatory time before/after self-admin1.21.42.10.9-1.4
Parametrial fat weight7.818.318.54.2-4.3
Pavlov. Cond. lever latency0.00.00.0-0.10.2
Pavlov. Cond. magazine entry latency0.40.50.50.6-0.7
Pavlov. Cond. change in total contacts0.00.00.1-0.2-0.0
Pavlov. Cond. index score0.10.10.20.2-0.4
Pavlov. Cond. latency score0.10.20.30.3-0.5
Pavlov. Cond. lever contacts0.10.10.10.2-0.4
Pavlov. Cond. magazine entry number0.10.10.1-0.30.3
Pavlov. Cond. intertrial magazine entries0.70.90.9-0.91.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.1-0.3
Pavlov. Cond. response bias0.20.30.30.5-0.6
Pavlov. Cond. lever latency1.52.02.11.4-1.4
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.1
Pavlov. Cond. change in total contacts0.81.31.4-1.11.2
Pavlov. Cond. index score1.01.41.6-1.11.3
Pavlov. Cond. latency score1.31.72.0-1.21.4
Pavlov. Cond. lever contacts0.81.11.2-1.01.1
Pavlov. Cond. magazine entry number0.00.10.1-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.70.91.1-0.81.0
Pavlov. Cond. response bias0.30.40.5-0.60.7
Time in closed arm before self-admin2.32.93.01.7-1.7
Time in closed arm after self-admin0.10.10.10.30.2
Time in open arm before self-admin2.62.84.3-1.22.1
Time in open arm after self-admin0.00.00.0-0.2-0.1
Bone: periosteal estimation0.51.11.4-0.91.2
Bone: periosteal perimeter0.10.10.2-0.20.5
Bone: post-yield work0.00.10.10.1-0.3
Progressive ratio test 1 active lever presses0.20.30.5-0.70.3
Progressive ratio test 1 breakpoint0.30.30.5-0.70.3
Progressive ratio test 1 inactive lever presses2.63.84.6-2.21.7
Progressive ratio test 2 active lever presses1.61.92.6-1.61.1
Progressive ratio test 2 breakpoint1.71.92.6-1.61.1
Progressive ratio test 2 inactive lever presses1.11.72.1-1.41.2
Incentive Sensitization - Responses0.60.81.2-1.10.7
Incentive Sensitization - Breakpoint0.60.81.1-1.10.6
Sum of active levers in priming session hrs 5-62.42.22.41.4-1.5
Progressive ratio1.42.22.7-1.61.3
Food seeking constrained by brief footshock0.00.00.0-0.2-0.1
Seeking ratio, punishment vs. effort0.81.11.31.1-1.0
Retroperitoneal fat weight2.39.811.03.3-2.9
Reaction time number correct0.20.51.01.00.1
Reaction time mean minus median0.30.80.80.9-0.9
Reaction time mean minus median AUC1.12.83.01.6-1.7
Reaction time num false alarms3.54.95.0-2.22.2
Reaction time num false alarms AUC4.06.36.4-2.52.5
Reaction time trials correct on left0.20.51.01.00.1
Reaction time trials on left0.30.51.01.00.1
Reaction time mean1.32.12.41.5-1.3
Reaction time mean AUC1.11.82.11.5-1.2
Median of all reaction times1.21.82.11.4-1.2
Reaction time omissions1.31.92.11.4-1.3
Reaction time false alarm rate4.05.66.8-2.62.1
Reaction time premature initiation rate1.72.42.51.6-1.5
Reaction time premature initiations1.22.23.21.8-1.1
Std. dev. reaction times0.50.90.90.9-0.9
Reaction time trials completed0.30.51.01.00.1
Reaction time trials AUC0.20.40.80.90.2
Run reversals in cocaine runway, females0.00.00.00.0-0.2
Run reversals in cocaine runway, males0.30.30.60.8-0.2
Latency to leave start box in cocaine runway0.20.20.40.00.7
Latency to leave start box in cocaine runway, F0.00.00.00.10.2
Latency to leave start box in cocaine runway, M0.20.10.3-0.00.5
Std. dev. time between licks in bursts1.11.52.1-1.41.0
Total sessions with >9 infusions0.60.71.10.6-1.0
Short access day 1 total inactive lever presses0.60.81.50.4-1.2
Short access day 10 total inactive lever presses0.30.81.1-0.71.1
Short access day 1 total infusions0.20.20.30.3-0.6
Short access day 10 total infusions0.40.61.10.2-1.0
Short access total infusions0.10.20.3-0.2-0.5
Short access day 1 locomotion0.10.20.3-0.50.2
Short access day 10 total locomotion1.42.62.9-1.71.5
Short access total locomotion1.51.72.4-1.51.1
One hour access (0.3 mA shock)0.60.71.2-1.10.4
Compulsive drug intake1.41.71.81.3-1.2
One hour access (shock baseline)0.61.01.5-1.20.7
Social response proportion2.52.82.81.7-1.7
Social responses0.60.80.80.9-0.8
Social time0.91.21.31.1-1.1
Soleus weight2.67.79.02.5-3.0
Bone: stiffness0.40.70.90.7-0.9
Tibialis anterior weight1.34.55.02.0-2.2
Time to tail flick, vehicle, before self-admin0.30.30.50.2-0.7
Time to tail flick, vehicle, after self-admin0.50.71.21.1-0.5
Time to tail flick, test, before self-admin0.00.00.1-0.20.2
Time to tail flick, test, after self-admin0.40.40.7-0.40.8
Delta time to tail flick, vehicle, before/after SA0.20.10.30.20.5
Delta time to tail flick, test, before/after SA0.60.60.6-0.80.8
Tibia length0.00.10.2-0.40.3
Ambulatory time before self-admin0.20.30.6-0.10.7
Ambulatory time after self-admin0.91.11.21.1-1.0
Bone: tissue strength0.40.40.4-0.60.7
Total heroin consumption2.42.83.31.5-1.8
Bone: trabecular number3.35.56.32.2-2.5
Bone: trabecular spacing1.21.51.6-1.21.3
Bone: trabecular thickness0.20.30.30.5-0.5
Bone: trabecular tissue density0.71.01.2-0.91.1
Water consumed over 24 hours0.40.50.80.9-0.6
Number of responses in last shaping day0.40.50.5-0.70.7