Ern1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ern1	0.04	0.02	2.2e-05	0.04	0.04	0.04	0.03	6.4e-05	1.0e-04	5.8e-05	1.2e-04
2	IL	gene expression	Ern1	0.15	0.09	6.0e-03	0.1	0.1	0.06	0.09	2.3e-03	2.8e-03	1.6e-02	3.4e-03
3	Liver	mRNA stability	Ern1	0.04	0.02	2.1e-05	0.04	0.03	0.01	0.03	3.5e-05	8.1e-04	9.8e-03	4.8e-04
4	Liver	gene expression	Ern1	0.11	0.05	1.1e-09	0.06	0.08	0.08	0.09	4.3e-07	2.2e-09	6.8e-09	9.1e-10
5	NAcc	mRNA stability	Ern1	0.04	0.02	2.5e-05	0.02	0.03	0.03	0.02	4.8e-04	7.2e-06	1.2e-05	1.2e-04
6	IL	alternative TSS	NM_001191926.1	0.36	0.14	1.3e-03	0.06	0.08	0.04	0.09	1.6e-02	5.0e-03	3.2e-02	4.3e-03
7	Liver	alternative TSS	XM_006247634.5	0.06	0.03	2.3e-03	0.01	0.01	0.03	0.01	3.3e-02	2.2e-02	9.6e-05	5.6e-02
8	Adipose	mRNA stability	Ern1	0.15	0.05	8.5e-14	0.14	0.11	0.13	0.13	8.4e-15	1.3e-12	3.6e-14	4.3e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.7	1.2	3.7	-0.7	-0.4	0.7	0.2	-1.1	-1.9	-1.6	-1.0
Area under the delay curve	0.4	0.7	1.9	-0.2	0.2	0.3	0.5	-0.6	-1.1	-1.4	-1.2
BMI with tail	1.0	3.6	7.5	-2.0	-1.3	2.0	-1.9	0.1	2.1	2.7	1.9
BMI without tail	1.1	5.9	10.0	-3.0	-2.0	3.2	-2.5	-0.5	2.0	3.1	2.0
Body weight	1.7	7.5	17.4	-4.2	-3.3	3.9	-2.7	-2.1	1.2	1.7	0.9
Weight adjusted by age	0.2	0.6	1.4	0.6	0.4	-0.7	1.1	0.6	-0.7	-0.7	-1.2
Bone surface	2.3	4.5	7.3	-2.6	-2.2	2.2	-0.7	-2.7	-2.2	-2.1	-1.7
Bone volume	1.8	3.5	5.4	-2.3	-1.8	2.1	-0.5	-2.3	-2.1	-1.8	-1.5
Breakpoint value in progressive ratio session	0.4	0.7	1.7	-0.1	-0.8	-0.0	-1.0	0.8	1.0	1.3	0.7
Number of licking bursts	0.1	0.3	1.0	0.1	-0.1	-0.3	0.4	0.1	-0.5	-0.9	-1.0
Context. condit. distance diff. score	0.2	0.2	0.7	-0.0	-0.2	-0.1	-0.1	0.7	0.8	0.7	0.1
Locomotion velocity, session 1	0.4	0.4	0.8	-0.8	-0.6	0.7	-0.1	-0.7	-0.9	-0.5	-0.4
Locomotion distance, session 1	0.3	0.4	1.6	-0.4	0.2	0.2	0.7	0.2	-1.2	-0.4	-0.9
Locomotion velocity, session 2	0.6	0.7	2.6	-0.6	-1.1	0.6	-0.7	0.3	0.4	1.6	0.5
Locomotion distance, session 2	0.2	0.2	0.8	-0.1	-0.1	0.1	0.3	0.9	-0.3	0.6	-0.7
Locomotion velocity, session 3	0.7	0.8	2.9	0.7	0.6	-0.7	0.7	1.7	-0.9	0.8	-0.8
Locomotion distance, session 3	0.3	0.3	1.0	-0.1	-0.2	-0.1	0.4	0.5	-1.0	-0.2	-0.9
Stereotopy head waving bouts, day 3	0.6	0.7	1.0	1.0	1.0	-0.8	0.9	0.5	-1.0	-0.8	-0.3
Stereotopy head waving duration, day 3	0.6	0.7	1.0	0.9	1.0	-0.7	1.0	0.6	-0.7	-0.9	-0.8
Locomotion velocity, session 7	0.3	0.3	0.6	0.7	0.7	-0.8	0.4	0.6	-0.3	0.5	0.2
Locomotion distance, session 7	0.1	0.1	0.8	-0.0	0.2	0.1	-0.2	0.3	0.2	0.9	0.1
Stereotopy head waving bouts, day 7	0.8	0.9	1.8	1.2	0.6	-1.1	1.1	1.3	-0.9	0.2	-0.8
Stereotopy head waving duration, day 7	1.4	1.7	3.4	1.9	1.0	-1.8	1.4	1.6	-0.7	-0.1	-0.9
Locomotion velocity, session 8	0.4	0.5	1.3	-0.8	-1.2	0.7	-0.5	-0.6	1.0	0.1	0.2
Locomotion distance, session 8	0.2	0.3	0.7	-0.5	-0.6	0.4	-0.3	0.6	0.7	0.8	-0.1
Degree of sensitization distance	0.3	0.3	0.8	-0.5	-0.0	0.7	-0.4	-0.9	0.8	0.1	0.3
Degree of sensitization stereotypy	1.2	1.3	4.1	1.3	0.7	-1.3	0.8	2.0	-0.3	1.3	-0.3
Conditioned locomotion	0.7	0.8	1.6	-0.8	-0.7	1.1	-1.3	-0.6	1.1	0.6	0.7
Cocaine response after cond. corrected	1.5	2.2	6.0	0.7	1.0	-0.9	1.4	-0.4	-1.9	-2.4	-1.9
Cocaine response after cond. not corrected	1.8	2.6	5.9	1.1	0.9	-1.3	1.6	0.1	-2.4	-2.1	-2.1
Cocaine response before conditioning	0.4	0.4	1.1	0.4	-0.1	-0.7	0.2	1.0	-0.7	1.0	-0.3
Saline control response	4.0	5.6	10.1	-1.5	-2.0	2.1	-2.7	0.0	3.0	3.2	2.6
Bone: connectivity density	1.0	1.5	2.6	-1.3	-0.9	1.2	-0.3	-1.5	-1.6	-1.6	-1.0
Bone: cortical apparent density	2.5	3.9	7.9	2.2	2.8	-2.4	2.1	2.3	-1.5	0.0	-0.8
Bone: cortical area	0.5	0.8	4.2	-0.9	-0.4	0.5	0.1	0.5	-2.0	0.0	-0.9
Bone: cortical porosity	2.3	2.5	7.2	-1.8	-2.7	1.7	-2.0	-0.9	-0.3	0.9	0.8
Bone: cortical porosity	1.4	1.6	4.9	-1.6	-2.2	1.4	-1.3	-0.6	-0.7	0.6	0.2
Bone: cortical thickness	6.0	10.1	19.1	3.3	3.8	-3.5	3.3	4.4	-3.4	0.5	-1.3
Bone: cortical thickness	3.5	4.3	10.9	2.3	2.3	-2.4	1.7	3.3	-1.6	1.6	0.1
Bone: cortical tissue density	2.3	3.6	7.5	2.2	2.7	-2.3	2.0	2.2	-1.3	0.2	-0.6
Condit. Reinf. active minus inactive responses	2.0	2.3	4.8	-1.7	-2.2	1.9	-1.8	-0.5	1.0	1.3	0.9
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.5	-1.0	-1.6	1.2	-1.2	-0.3	0.7	0.8	0.5
Condit. Reinf. active responses	2.4	3.0	6.1	-2.2	-2.5	2.3	-2.0	-0.9	1.2	1.1	0.7
Condit. Reinf. inactive responses	0.6	0.8	1.9	-1.4	-0.9	1.2	-0.7	-1.0	0.1	-0.5	-0.4
Incentive salience index mean	1.4	1.9	5.0	-1.6	-2.2	1.7	-1.6	-0.5	0.5	0.9	0.6
Condit. Reinf. lever presses	0.4	0.5	1.6	-0.5	-1.3	0.6	-0.8	0.1	0.4	1.0	0.5
Condit. Reinf. active minus inactive responses	2.0	3.1	7.3	-2.5	-2.7	2.4	-1.3	-0.9	-0.9	-0.5	-1.2
Condit. Reinf. active-inactive response ratio	1.0	1.6	4.2	-1.5	-2.1	1.6	-1.0	-1.1	-0.6	-0.7	-0.6
Condit. Reinf. active responses	3.3	4.7	10.7	-3.2	-3.3	3.1	-2.3	-1.3	0.3	0.6	-0.1
Condit. Reinf. inactive responses	1.8	2.7	4.9	-2.2	-1.8	2.0	-1.8	-0.2	1.2	1.9	1.0
Condit. Reinf. lever presses	1.5	2.2	3.8	-1.6	-2.0	1.7	-1.8	0.1	0.8	1.8	0.9
Condit. Reinf. lever reinforcers received	2.9	4.1	9.0	-3.0	-3.0	2.9	-2.2	-1.3	0.2	0.5	-0.0
Conditioned reinforcement - actives	0.2	0.9	1.5	-1.0	-1.0	1.2	-1.0	-0.2	0.9	1.2	0.3
Conditioned reinforcement - inactives	0.4	1.1	1.9	-1.4	-1.0	1.3	-1.3	-0.6	0.3	1.3	0.9
Conditioned locomotion	2.2	3.3	5.3	-2.3	-2.2	2.2	-2.3	-1.3	1.2	1.3	1.1
Patch foraging indifference point 0 sec	1.3	3.7	8.9	-3.0	-2.2	3.0	-2.1	-1.3	0.6	0.8	0.3
Patch foraging indifference point AUC	0.3	0.7	2.0	-1.4	-1.2	1.0	-0.7	-0.7	0.6	0.2	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	2.7	0.5	0.6	-0.7	1.0	-0.2	-0.8	-1.6	-1.1
Delay disc. indifference point, 16s delay	0.2	0.4	0.8	-0.5	-0.1	0.9	0.0	-0.6	-0.6	-0.9	-0.6
Delay disc. indifference point, 2s delay	2.7	3.0	8.7	-0.9	-0.3	0.6	1.1	-1.6	-2.0	-2.9	-2.5
Delay disc. indifference point, 24s delay	0.4	0.7	2.2	-1.3	-0.6	1.5	-0.5	-1.0	0.0	-0.3	-0.2
Delay disc. indifference point, 4s delay	1.2	1.2	3.6	0.9	0.8	-0.9	1.2	0.5	-1.9	-0.8	-1.3
Delay disc. indifference point, 8s delay	0.4	0.7	2.0	0.1	0.5	-0.1	0.7	-0.4	-1.2	-1.4	-1.0
Indifference point function ln k	0.3	1.0	1.8	1.0	1.2	-0.9	0.8	1.3	-1.3	-0.1	-0.7
Indifference point function log k	0.3	1.0	1.8	1.0	1.2	-0.9	0.8	1.3	-1.3	-0.1	-0.7
Patch foraging total patch changes 0 sec	1.3	3.9	9.3	-3.0	-2.3	3.0	-2.1	-1.5	0.5	0.6	0.2
Patch foraging total patch changes 12 sec	4.2	5.7	11.9	-3.4	-3.3	3.1	-2.1	-2.3	1.8	0.5	0.4
Patch foraging total patch changes 18 sec	1.3	3.0	5.4	-2.3	-2.1	2.2	-2.0	-0.8	1.4	1.3	0.9
Patch foraging total patch changes 24 sec	0.7	2.4	6.6	-2.6	-1.9	2.4	-1.4	-1.2	-0.1	0.3	-0.3
Patch foraging total patch changes 6 sec	1.3	2.2	5.4	-2.3	-1.9	2.1	-1.6	-1.0	0.3	0.9	0.2
Patch foraging time to switch 0 sec	0.1	0.3	0.7	0.8	0.2	-0.7	0.3	0.2	0.4	0.5	0.8
Patch foraging water rate 0 sec	0.4	1.4	3.6	-1.9	-1.0	1.8	-1.4	-1.0	0.2	0.2	0.5
Patch foraging water rate 12 sec	0.6	2.4	5.4	1.4	2.0	-1.4	1.4	1.6	-2.3	-0.1	-1.2
Patch foraging water rate 18 sec	0.7	1.5	4.7	0.5	1.0	-0.5	1.0	0.8	-2.2	-1.1	-1.7
Patch foraging water rate 24 sec	0.4	0.6	1.7	0.3	0.5	-0.4	0.7	0.2	-1.1	-0.8	-1.3
Patch foraging water rate 6 sec	0.4	0.6	2.7	0.2	0.8	-0.4	0.4	0.3	-1.7	-0.8	-0.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.9	0.1	0.1	0.2	-0.5	0.3	1.0	1.4	1.3
Distance traveled before self-admin	0.8	1.7	3.2	1.0	0.9	-1.3	1.2	0.9	-1.6	-1.4	-1.8
Distance traveled after self-admin	0.2	0.3	1.4	0.4	0.1	-0.5	0.3	0.8	-0.2	-0.4	-1.2
Extensor digitorum longus weight	0.8	3.2	12.4	1.5	1.6	-0.9	-0.1	0.1	3.5	0.5	2.7
Bone: elastic displacement	2.0	2.5	3.7	1.9	1.8	-1.9	1.7	1.9	-1.5	0.2	-0.6
Bone: elastic work	0.3	0.3	1.1	0.4	0.6	-0.5	0.4	0.8	-1.0	0.1	0.2
Bone: endosteal estimation	8.0	19.6	35.1	-5.9	-5.9	5.7	-4.9	-5.2	1.6	-0.0	0.9
Bone: endosteal perimeter	8.0	19.6	38.3	-6.2	-6.0	5.9	-4.2	-5.4	0.8	-1.0	-0.1
Epididymis fat weight	0.1	0.7	1.5	-1.2	-0.8	1.2	-0.8	-1.0	0.8	0.2	0.3
Delta time in closed arm before/after self-admin	0.5	0.5	1.5	0.3	0.4	-0.7	0.6	-0.4	-1.1	-1.2	-0.3
Delta time in open arm before/after self-admin	0.6	0.7	4.0	-0.1	0.1	0.4	-0.6	0.1	2.0	0.6	0.5
Diff in mean of infusions in LGA sessions	0.9	1.6	3.1	1.6	1.3	-1.4	0.6	1.8	0.8	1.5	0.8
Delay discount exponential model param	0.5	0.7	1.8	0.4	0.0	-0.5	-0.5	0.8	1.0	1.4	1.2
Extinction: sum of active levers before priming	0.2	0.3	1.3	-0.4	-0.3	0.4	-0.4	0.3	1.2	0.5	0.1
Active lever presses in extinction session 6	1.2	1.2	2.1	-1.4	-1.4	1.3	-1.3	-0.4	0.6	1.1	0.8
Bone: final force	0.9	1.4	6.3	-0.7	-0.2	0.0	0.7	0.0	-2.5	-1.0	-1.7
Bone: final moment	0.8	1.3	6.5	-0.6	-0.1	-0.1	0.6	0.1	-2.6	-1.0	-1.6
Food consumed during 24 hour testing period	1.4	2.9	4.6	-2.1	-1.8	2.1	-2.0	-1.4	1.8	0.7	1.1
Glucose	1.1	1.7	2.7	1.4	1.3	-1.5	1.6	1.4	-0.9	-0.5	-1.3
Heart weight	1.0	1.6	3.6	0.6	1.3	-0.6	1.5	0.5	-1.7	-1.1	-1.9
Delay discount hyperbolic model param	0.6	0.8	2.3	0.5	0.1	-0.4	-0.5	0.9	1.1	1.5	1.2
Intermittent access intake day 1-15 change	0.0	0.2	0.8	0.1	-0.1	0.1	-0.4	-0.5	0.9	0.1	0.9
Intermittent access intake escalation	0.1	0.4	0.8	-0.4	-0.6	0.6	-0.7	-0.7	0.9	0.1	0.8
Intermittent access intake escalation 2	0.5	0.9	1.7	-0.6	-0.8	0.7	-1.0	-1.2	1.3	-0.1	1.2
Intermitt. access day 1 inactive lever presses	0.3	3.5	5.5	-2.1	-2.3	2.2	-2.3	-1.2	1.0	1.6	1.8
Intermitt. access day 15 inactive lever presses	0.6	3.0	8.1	-1.3	-1.3	1.7	-2.4	-1.1	1.0	1.3	2.8
Intermitt. access escalation Index	0.9	2.8	4.3	2.0	1.6	-1.8	2.1	1.6	-1.2	-0.9	-1.7
Intermittent access day 1 total infusions	0.2	0.7	1.5	-1.2	-1.0	1.0	-0.7	0.4	-0.3	1.1	-0.5
Intermittent access day 15 total infusions	0.5	1.3	2.7	-1.6	-1.4	1.7	-1.3	-0.8	0.6	0.6	0.3
Intermittent access terminal intake (last 3 days)	1.5	2.6	5.2	-2.3	-2.0	2.2	-1.8	-1.6	0.9	0.3	0.5
Intermittent access total infusions	1.6	1.9	4.8	-2.2	-1.8	2.0	-1.3	-0.9	0.4	0.7	-0.1
Intermittent access day 1 locomotion	1.6	2.9	5.2	-2.3	-2.1	2.1	-2.0	-0.3	0.2	2.1	0.8
Intermittent access day 15 total locomotion	1.2	4.6	8.7	-2.9	-2.8	2.7	-2.4	-1.4	1.6	1.5	0.9
Intermittent access total locomotion	5.0	6.0	12.0	-3.5	-3.2	3.1	-2.6	-1.1	1.2	2.5	1.0
Intermittent access standard deviation	0.2	1.2	1.7	-1.0	-1.0	1.0	-1.3	-0.8	1.2	1.3	1.3
Left kidney weight	0.3	2.7	6.4	0.8	1.3	-0.9	1.9	1.5	-2.5	-0.6	-2.3
Right kidney weight	0.4	3.0	8.2	0.6	1.2	-0.8	1.9	0.9	-2.9	-1.5	-2.6
Cocaine induced anxiety	0.5	1.3	4.0	1.1	1.0	-0.9	1.1	1.0	-2.0	-0.3	-0.9
Post-drug Anxiety	1.3	1.4	3.8	1.1	1.3	-1.2	1.2	0.9	-2.0	-0.7	-0.8
Baseline Anxiety	0.1	0.1	0.4	0.2	0.5	-0.4	-0.0	0.1	0.5	0.1	0.6
Tail length	1.0	5.5	11.2	-3.3	-3.0	3.2	-2.5	-2.0	0.4	1.4	1.0
Length with tail	1.2	5.1	10.7	-3.3	-2.9	3.0	-1.3	-3.0	-0.4	-0.8	-0.9
Length without tail	0.2	1.3	3.4	-1.0	-0.7	0.7	0.2	-1.8	-0.6	-1.7	-1.2
Times rat made contact with spout	0.4	0.5	0.8	-0.8	-0.8	0.8	-0.8	-0.9	0.3	-0.5	0.1
Lifetime Intake	1.8	2.2	5.3	-2.3	-1.9	2.1	-1.5	-0.6	0.5	1.0	0.1
Liver weight, left	1.5	2.6	7.2	-2.3	-2.7	2.0	-1.2	-1.5	-0.4	0.0	-0.8
Liver weight, right	1.5	2.6	6.1	1.4	1.7	-1.4	1.7	1.8	-2.5	0.2	-1.2
Locomotor activity	0.7	1.1	4.2	-0.7	-0.6	0.5	-1.0	1.5	0.6	2.1	0.2
Locomotor testing distance	1.0	2.6	8.4	-1.0	-1.1	1.0	-1.9	1.5	1.3	2.9	1.2
Locomotor testing rearing	1.6	5.7	15.3	-1.0	-1.6	1.2	-3.0	0.9	2.8	3.9	2.8
Locomotion in novel chamber	0.8	1.1	5.3	0.4	0.2	-0.4	1.1	-0.0	-2.3	-0.1	-1.4
Locomotion in novel chamber post-restriction	1.0	3.1	8.4	-1.6	-1.2	1.1	0.3	-2.2	-1.2	-2.9	-2.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.6	-0.1	-0.1	0.3	-0.3	-0.7	-0.0	-0.8	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.0	0.4	-0.1	0.6	-0.6	0.5	-0.7	-0.1
Time >=10cm from walls, locomotor time 1	1.8	2.2	3.6	1.7	1.5	-1.9	1.9	1.5	-0.8	-0.7	-1.6
Bouts of movement, locomotor time 1	0.3	0.4	1.5	0.5	0.7	-0.2	0.0	0.2	0.2	1.0	1.2
Total resting periods, locomotor time 1	0.3	0.3	1.1	0.5	0.8	-0.2	0.2	-0.1	0.1	0.7	1.1
Rest time, locomotor task time 1	0.2	0.3	1.1	0.4	0.4	-0.3	0.1	-0.9	0.0	-1.1	0.1
Distance moved, locomotor task time 1	0.1	0.3	0.9	-0.7	-0.6	0.7	-0.4	-0.1	0.1	1.0	0.5
Vertical activity count, locomotor time 1	0.0	0.1	0.4	-0.5	-0.3	0.3	-0.0	-0.1	-0.6	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	0.6	0.1	-0.9	0.1	0.4	-0.3	-0.2	-0.0
Bouts of movement, locomotor time 2	0.2	0.6	2.4	0.5	0.5	-0.1	0.0	0.6	0.7	1.5	1.0
Total resting periods, locomotor time 2	0.2	0.6	2.3	0.7	0.7	-0.4	0.2	0.9	0.4	1.5	0.9
Rest time, locomotor task time 2	1.5	2.5	4.3	2.0	2.1	-1.7	1.8	0.6	-0.9	-1.7	-1.2
Distance moved, locomotor task time 2	0.8	1.1	3.2	-0.7	-1.0	0.4	-1.0	-0.1	0.5	1.8	1.6
Vertical activity count, locomotor time 2	1.2	2.8	5.5	-1.5	-1.8	1.2	-2.3	-0.4	1.1	1.8	2.3
Light reinforcement 1	0.1	0.2	0.4	-0.6	-0.0	0.5	-0.6	0.6	0.3	0.6	0.2
Light reinforcement 2	0.1	0.3	0.8	-0.8	-0.3	0.4	-0.3	-0.4	-0.5	-0.9	-0.0
Bone: marrow area	7.7	18.8	33.4	-5.8	-5.7	5.6	-4.8	-5.1	1.5	-0.1	0.9
Bone: maximum diameter	1.9	3.9	7.9	-2.8	-2.4	2.4	-1.1	-2.2	-1.5	-1.6	-1.3
Bone: maximum force	0.8	1.6	5.1	-1.4	-0.5	1.0	0.3	-0.5	-2.3	-1.0	-1.8
Bone: maximum moment	0.8	1.4	5.2	-1.3	-0.4	0.9	0.2	-0.5	-2.3	-0.9	-1.6
Mean time between licks in bursts	0.1	0.6	1.5	-0.7	-0.2	0.6	0.4	-1.1	-0.3	-1.2	-0.8
Mean num. licks in bursts	0.2	0.6	1.5	-0.6	-0.4	0.9	-0.9	-0.7	0.9	0.6	1.2
Cd content in liver	1.1	1.2	3.1	1.7	1.4	-1.5	0.9	0.0	1.1	-0.3	0.6
Co content in liver	0.6	0.7	1.5	1.2	0.6	-1.1	0.8	0.7	1.0	-0.3	0.4
Cu content in liver	0.4	0.4	1.0	-0.5	-0.5	0.5	-0.7	-1.0	0.6	-0.3	0.8
Fe content in liver	0.2	0.3	1.2	0.0	-0.3	-0.2	0.0	0.9	-0.1	1.1	-0.4
K content in liver	0.6	0.6	1.7	-0.5	-0.5	0.4	0.3	-0.6	-0.6	-1.2	-1.3
Mg content in liver	0.3	0.3	0.7	0.6	0.5	-0.6	0.7	-0.2	0.2	-0.8	-0.4
Mn content in liver	1.2	1.4	3.5	0.5	0.7	-0.7	1.2	0.5	-1.8	-1.2	-1.9
Na content in liver	0.2	0.3	1.2	-0.4	-1.1	0.6	-0.2	0.2	0.3	0.1	-0.5
Rb content in liver	3.0	3.5	5.4	2.3	2.2	-2.3	2.3	1.7	-1.2	-1.0	-1.4
Se content in liver	1.2	1.4	2.8	0.9	1.1	-1.1	1.7	1.4	-0.7	-0.4	-1.7
Sr content in liver	0.3	0.2	0.4	-0.7	-0.5	0.5	-0.3	-0.6	-0.3	-0.5	-0.1
Zn content in liver	0.8	1.0	1.7	0.8	0.8	-1.0	1.3	0.3	-0.9	-1.3	-1.1
Bone: minimum diameter	6.4	12.4	26.0	-5.1	-4.6	4.9	-3.5	-4.0	0.2	-0.1	0.1
Time in familiar zone, hab. session 1	1.2	1.3	2.3	-1.1	-0.9	1.4	-1.1	-1.5	1.5	0.0	0.5
Time in novel zone, hab. session 1	1.4	1.6	3.2	1.4	1.4	-1.7	1.0	1.8	-1.3	0.5	-0.1
Total zone transitions, hab. session 1	0.2	0.2	1.0	-0.4	-0.1	0.4	-0.0	0.5	0.1	1.0	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.9	-0.4	0.7	-0.1	0.3	-0.6	0.7	-0.1
Locomotion velocity, hab. session 1	0.3	0.5	1.5	-1.2	-0.8	1.0	-0.3	-0.2	-0.5	0.4	-0.3
Time in familiar zone, hab. session 2	1.7	1.9	3.2	-1.4	-1.7	1.4	-1.6	-0.8	1.8	1.0	0.9
Time in novel zone, hab. session 2	2.2	2.5	5.2	1.3	1.9	-1.5	1.8	0.5	-2.3	-1.5	-1.0
Total zone transitions, hab. session 2	0.3	0.3	1.5	-0.4	-0.4	0.4	-0.2	0.6	0.6	1.2	-0.1
Total locomotion distance, hab. session 2	0.4	0.5	1.2	-1.0	-0.5	1.1	-0.5	-0.2	0.6	0.9	0.3
Locomotion velocity, hab. session 2	0.3	0.3	1.0	-1.0	-0.4	1.0	-0.2	-0.3	0.3	0.6	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.6	-0.3	0.2	0.0	-0.3	-0.6	-0.3	-0.2
Novelty place preference	0.1	0.1	0.4	-0.3	-0.1	0.0	0.2	-0.0	-0.6	-0.1	-0.1
Time in novel zone, NPP test	0.1	0.1	0.6	-0.1	-0.0	-0.2	0.3	0.2	-0.7	0.0	-0.2
Total zone transitions, NPP test	0.3	0.4	1.5	-0.2	0.3	0.2	0.7	0.9	-0.8	0.3	-1.2
Total locomotion distance, NPP test	0.2	0.3	0.9	-0.9	-0.3	0.8	-0.1	-0.3	-0.6	0.1	-0.4
Locomotion velocity, NPP test	0.2	0.3	0.9	-1.0	-0.1	1.0	-0.1	-0.2	-0.3	0.2	-0.3
Intraocular pressure	0.5	0.8	1.7	-1.0	-0.3	1.3	-1.3	-0.1	0.9	0.8	1.0
Delta distance traveled before/after self-admin	0.6	0.7	2.8	-0.0	-0.2	0.0	-0.5	1.1	1.0	1.7	0.7
Delta ambulatory time before/after self-admin	0.2	0.4	1.0	-0.5	-0.5	0.5	-0.6	0.2	0.8	1.0	0.5
Parametrial fat weight	1.1	2.5	9.2	-0.3	0.2	0.0	0.7	-2.2	-1.9	-3.0	-1.2
Pavlov. Cond. lever latency	0.9	1.2	3.5	1.0	1.6	-1.0	1.0	-0.5	0.0	-1.9	-0.2
Pavlov. Cond. magazine entry latency	1.7	2.1	5.3	-1.8	-2.3	2.0	-1.4	-0.7	0.4	1.3	0.3
Pavlov. Cond. change in total contacts	2.0	2.2	4.6	-1.4	-2.0	1.5	-1.6	-0.0	0.8	2.1	1.1
Pavlov. Cond. index score	1.5	1.9	4.9	-1.6	-2.2	1.8	-1.3	-0.3	0.3	1.6	0.3
Pavlov. Cond. latency score	1.3	1.7	4.3	-1.5	-2.1	1.6	-1.2	0.0	0.3	1.7	0.2
Pavlov. Cond. lever contacts	1.3	1.5	3.5	-1.1	-1.9	1.2	-1.4	-0.1	0.4	1.8	0.8
Pavlov. Cond. magazine entry number	1.4	1.8	4.6	1.5	2.1	-1.7	1.4	0.5	-0.5	-1.4	-0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.1	2.8	-1.7	-1.0	1.7	-1.1	-0.6	1.0	0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	4.4	-1.5	-2.1	1.7	-1.2	-0.3	0.1	1.4	0.2
Pavlov. Cond. response bias	1.6	2.0	5.6	-1.8	-2.4	1.8	-1.4	-0.7	-0.2	1.2	0.2
Pavlov. Cond. lever latency	0.2	0.2	0.8	0.7	0.9	-0.6	0.4	-0.1	0.1	-0.2	0.4
Pavlov. Cond. magazine entry latency	1.7	2.4	3.6	1.7	1.4	-1.9	1.9	1.4	-1.0	-1.1	-1.7
Pavlov. Cond. change in total contacts	0.3	0.8	2.2	-1.0	-1.5	1.0	-0.9	-0.2	0.9	0.5	-0.2
Pavlov. Cond. index score	0.1	0.2	0.7	0.0	-0.3	-0.2	0.2	0.6	-0.3	-0.0	-0.9
Pavlov. Cond. latency score	0.2	0.3	1.0	0.3	-0.1	-0.5	0.4	0.9	-0.6	-0.0	-1.0
Pavlov. Cond. lever contacts	0.1	0.2	0.5	-0.6	-0.7	0.6	-0.4	0.3	0.1	0.3	-0.2
Pavlov. Cond. magazine entry number	2.6	3.4	5.3	-2.1	-1.8	2.3	-2.1	-1.9	1.4	0.9	1.8
Pavlov. Cond. intertrial magazine entries	5.7	12.4	20.1	-4.5	-3.9	4.5	-4.0	-4.2	2.1	0.1	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.2	0.2	-0.1	-0.4	0.4	0.6	-0.5	-0.3	-1.1
Pavlov. Cond. response bias	0.1	0.2	0.8	-0.2	-0.4	0.1	0.2	0.5	-0.3	-0.2	-0.9
Time in closed arm before self-admin	0.5	0.9	4.5	0.4	0.2	-0.5	-0.2	1.5	-0.0	2.1	0.6
Time in closed arm after self-admin	0.7	0.8	1.8	0.9	0.9	-1.3	1.0	0.5	-1.2	-0.3	-0.4
Time in open arm before self-admin	1.4	1.7	3.7	1.2	1.1	-1.3	1.5	0.6	-1.9	-1.3	-1.2
Time in open arm after self-admin	0.3	0.4	1.3	-0.5	-0.4	0.8	-0.4	-0.5	1.1	-0.2	0.0
Bone: periosteal estimation	3.7	8.7	18.9	-4.3	-4.0	4.0	-3.0	-3.1	-0.5	-0.3	-0.2
Bone: periosteal perimeter	1.8	3.6	7.1	-2.7	-2.5	2.2	-1.0	-1.8	-1.6	-1.3	-1.3
Bone: post-yield work	0.6	1.0	2.3	-1.5	-1.3	1.4	-0.8	-1.2	-0.3	-0.2	-0.4
Progressive ratio test 1 active lever presses	1.0	1.7	4.2	-2.1	-1.7	1.8	-1.4	-0.3	0.0	1.1	0.1
Progressive ratio test 1 breakpoint	1.2	2.1	5.0	-2.2	-1.9	2.0	-1.6	-0.5	0.2	1.1	0.3
Progressive ratio test 1 inactive lever presses	1.0	2.6	6.2	-2.5	-2.2	2.1	-1.9	-0.5	0.4	1.0	0.4
Progressive ratio test 2 active lever presses	2.4	3.5	7.7	-2.8	-2.4	2.7	-1.9	-1.7	0.1	-0.3	-0.1
Progressive ratio test 2 breakpoint	3.0	3.8	8.3	-2.9	-2.5	2.9	-2.0	-1.9	0.2	-0.3	-0.1
Progressive ratio test 2 inactive lever presses	0.7	2.2	5.2	-2.2	-1.7	2.3	-1.6	-1.1	0.3	0.5	0.7
Incentive Sensitization - Responses	0.9	2.5	5.3	-2.1	-1.8	2.3	-1.3	-1.9	-0.2	-1.0	-0.4
Incentive Sensitization - Breakpoint	1.1	2.5	5.1	-2.1	-1.8	2.3	-1.4	-1.9	-0.2	-1.1	-0.4
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.5	0.9	0.4	-0.5	-0.2	1.6	1.3	1.1	0.3
Progressive ratio	0.4	1.1	4.7	-0.3	-0.0	0.2	0.6	-1.2	-0.6	-2.2	-1.4
Food seeking constrained by brief footshock	2.9	3.6	6.9	-2.1	-2.6	2.0	-2.0	-2.0	2.0	0.6	1.0
Seeking ratio, punishment vs. effort	1.2	2.7	5.1	-1.4	-1.9	1.2	-1.9	-0.2	1.6	2.3	1.8
Retroperitoneal fat weight	0.2	1.1	2.1	-1.4	-1.0	1.3	-1.1	-1.5	0.5	0.2	0.7
Reaction time number correct	0.7	2.3	4.7	1.0	1.6	-1.0	1.7	0.5	-2.0	-1.5	-2.2
Reaction time mean minus median	0.0	0.3	1.0	0.6	0.6	-0.4	-0.2	-0.2	0.4	0.5	1.0
Reaction time mean minus median AUC	0.1	1.0	2.0	1.3	1.4	-1.3	1.2	0.7	-0.7	-0.2	-0.4
Reaction time num false alarms	1.1	1.8	4.7	-2.1	-2.2	1.7	-1.1	-0.8	0.0	-0.3	-0.6
Reaction time num false alarms AUC	0.9	2.1	4.8	-2.2	-2.2	1.8	-1.1	-1.2	-0.2	-0.8	-0.7
Reaction time trials correct on left	0.7	2.3	4.7	1.0	1.6	-1.0	1.7	0.5	-2.0	-1.5	-2.2
Reaction time trials on left	0.7	2.4	4.8	0.9	1.6	-1.0	1.7	0.4	-2.0	-1.6	-2.2
Reaction time mean	0.3	0.6	1.5	1.2	1.1	-1.1	0.6	0.6	-0.5	0.3	-0.1
Reaction time mean AUC	0.4	0.9	2.3	1.5	1.2	-1.3	0.5	0.9	-0.2	0.7	0.2
Median of all reaction times	0.5	0.8	1.6	1.3	1.1	-1.1	0.8	0.8	-0.6	0.3	-0.4
Reaction time omissions	0.2	0.3	1.4	-0.4	0.1	0.3	-0.3	-1.2	-0.7	-0.3	0.4
Reaction time false alarm rate	2.0	2.7	7.2	-2.2	-2.7	2.0	-1.8	-1.1	0.9	0.2	0.6
Reaction time premature initiation rate	0.4	0.7	1.1	-1.0	-0.9	1.1	-1.0	-0.2	0.7	0.7	0.7
Reaction time premature initiations	0.0	0.1	0.4	-0.6	-0.1	0.6	-0.2	-0.2	-0.3	-0.4	-0.5
Std. dev. reaction times	0.1	0.3	0.6	0.7	0.6	-0.7	0.1	-0.4	0.0	0.1	0.7
Reaction time trials completed	0.7	2.4	4.8	0.9	1.6	-1.0	1.7	0.4	-2.0	-1.6	-2.2
Reaction time trials AUC	0.7	2.3	4.6	0.9	1.6	-0.9	1.7	0.3	-1.9	-1.5	-2.1
Run reversals in cocaine runway, females	0.6	0.7	2.8	1.0	1.2	-0.3	-0.1	-0.2	0.2	0.2	1.7
Run reversals in cocaine runway, males	0.6	0.6	2.2	0.2	0.3	-0.4	0.7	-0.2	-1.3	-1.5	-0.7
Latency to leave start box in cocaine runway	0.1	0.2	0.8	0.5	0.2	-0.6	0.2	0.9	0.1	0.3	0.1
Latency to leave start box in cocaine runway, F	0.8	1.0	3.2	0.9	0.4	-1.0	0.9	1.8	-1.1	0.8	-0.5
Latency to leave start box in cocaine runway, M	0.7	0.7	2.9	-0.2	-0.3	0.4	-1.0	-0.6	1.7	-0.2	1.0
Std. dev. time between licks in bursts	0.1	0.3	0.6	-0.3	-0.3	0.4	-0.4	-0.1	0.8	0.8	0.7
Total sessions with >9 infusions	0.5	0.6	2.5	-0.5	-0.2	0.5	-0.6	1.3	0.4	1.6	0.3
Short access day 1 total inactive lever presses	0.5	1.1	2.5	-1.6	-1.2	1.3	-1.0	-0.3	-0.5	1.1	0.7
Short access day 10 total inactive lever presses	0.1	0.4	1.5	-0.5	-0.3	0.6	-0.7	-0.5	0.0	0.4	1.2
Short access day 1 total infusions	0.3	0.7	2.5	-0.6	-0.4	0.7	-0.4	1.6	0.3	1.2	0.1
Short access day 10 total infusions	1.5	2.4	5.0	-2.2	-1.8	1.9	-1.8	-0.3	0.9	1.7	0.8
Short access total infusions	0.8	1.2	2.0	-1.4	-1.2	1.3	-1.2	0.6	0.4	1.4	0.5
Short access day 1 locomotion	1.3	2.1	5.3	-1.7	-1.2	1.7	-1.6	0.6	0.8	2.3	0.8
Short access day 10 total locomotion	1.7	6.9	10.1	-3.0	-3.1	2.9	-3.2	-1.2	2.0	2.7	2.3
Short access total locomotion	2.4	3.7	8.2	-2.2	-1.9	1.9	-2.2	0.1	1.3	2.9	1.6
One hour access (0.3 mA shock)	0.6	0.7	1.7	-1.2	-1.3	1.2	-0.9	-0.5	0.3	0.0	-0.1
Compulsive drug intake	1.5	2.2	3.6	1.3	1.2	-1.5	1.7	0.5	-1.9	-1.5	-1.7
One hour access (shock baseline)	0.8	2.1	3.4	-1.8	-1.7	1.8	-1.7	-0.9	1.3	1.0	0.9
Social response proportion	0.1	0.2	0.4	0.5	0.7	-0.4	0.4	0.3	-0.2	-0.1	-0.2
Social responses	0.2	0.2	0.8	-0.1	-0.0	0.1	-0.5	0.7	0.4	0.9	0.2
Social time	0.1	0.1	0.4	0.4	0.3	0.0	-0.4	-0.6	0.0	-0.6	0.2
Soleus weight	0.0	0.1	0.3	-0.2	-0.5	0.4	-0.0	0.6	-0.2	0.1	-0.3
Bone: stiffness	0.6	1.2	4.4	-1.1	-0.5	0.7	0.5	-0.3	-1.4	-0.9	-2.1
Tibialis anterior weight	1.0	3.3	10.7	-0.8	-1.0	1.1	-1.7	-0.5	3.3	1.5	2.7
Time to tail flick, vehicle, before self-admin	1.9	2.3	5.4	0.5	0.3	-0.8	1.4	-0.8	-2.3	-2.2	-2.2
Time to tail flick, vehicle, after self-admin	0.7	1.4	5.6	-0.2	0.3	0.0	0.9	-0.7	-1.4	-2.4	-1.6
Time to tail flick, test, before self-admin	0.4	0.5	1.2	0.3	-0.0	-0.2	-0.6	0.1	1.1	1.0	1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.2	-0.5	0.3	0.1	-0.1	0.2	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	1.1	1.2	1.8	-1.2	-0.8	1.3	-1.2	-1.3	1.0	-0.5	1.0
Delta time to tail flick, test, before/after SA	0.6	0.8	2.6	-0.1	-0.2	0.0	0.9	-0.4	-0.8	-1.4	-1.6
Tibia length	1.0	2.7	6.3	0.3	0.9	-0.9	1.9	0.8	-2.5	-1.7	-2.5
Ambulatory time before self-admin	0.4	1.3	2.8	0.7	0.6	-1.0	1.0	0.6	-1.6	-1.2	-1.7
Ambulatory time after self-admin	0.1	0.1	0.5	0.1	-0.0	-0.2	-0.0	0.7	-0.1	-0.0	-0.5
Bone: tissue strength	1.9	1.9	3.5	1.2	1.5	-1.1	1.8	1.4	-1.5	-0.3	-1.9
Total heroin consumption	0.3	0.4	1.2	-0.5	-1.1	0.2	-0.4	0.6	-0.4	0.6	-0.8
Bone: trabecular number	1.0	1.8	4.0	-1.3	-0.9	1.3	-0.2	-1.4	-2.0	-1.7	-1.2
Bone: trabecular spacing	0.6	0.9	3.3	0.3	-0.1	-0.4	-0.4	0.5	1.8	1.6	0.8
Bone: trabecular thickness	1.2	1.7	4.0	-1.2	-0.7	1.2	-0.3	-1.6	-2.0	-1.8	-0.5
Bone: trabecular tissue density	2.4	4.1	9.1	1.2	2.1	-1.5	2.6	1.0	-3.0	-1.4	-2.5
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1	-0.2	-0.1	0.1
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.1	0.0	-0.2	0.4	-0.3	0.5	0.2