Hub : Genes

Ercc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS XM_039103939.2 0.03 0.03 5.5e-03 0.01 0.01 0.01 0.01 1.8e-02 3.1e-02 1.4e-02 2.4e-02
2 NAcc alternative TSS XM_039103939.2 0.02 0.02 1.5e-03 0.01 0.01 0.01 0.01 4.1e-03 5.7e-03 4.0e-03 7.2e-03
3 NAcc isoform ratio XM_039103939.2 0.02 0.02 3.2e-03 0.01 0.01 0.01 0.01 5.1e-03 7.0e-03 2.6e-02 8.7e-03
4 NAcc isoform ratio NM_001106228.1 0.01 0.01 9.2e-03 0.01 0.01 0.01 0.01 2.7e-02 1.1e-02 2.6e-02 3.6e-02
5 NAcc alternative TSS NM_001106228.1 0.01 0.01 9.7e-03 0.01 0.01 0.01 0.01 2.4e-02 1.6e-02 3.3e-02 2.5e-02
6 pVTA alternative TSS XM_039103939.2 0.04 0.04 7.7e-03 0 0 -0 0 1.4e-01 1.3e-01 6.1e-01 2.8e-01
7 pVTA isoform ratio XM_039103939.2 0.04 0.04 8.3e-03 0 0.01 -0 0 1.2e-01 7.5e-02 7.5e-01 2.3e-01
8 BLA intron excision ratio chr1_88125145_88125240 0.09 0.08 5.6e-04 0.03 0.04 0.03 0.03 7.2e-03 5.4e-03 1.3e-02 1.3e-02
9 Brain alternative TSS NM_001106228.1 0.02 0.02 9.6e-03 0 0 -0 0 1.1e-01 1.8e-01 9.4e-01 3.0e-01
10 Brain isoform ratio NM_001106228.1 0.02 0.02 6.7e-03 0.01 0 0 0 4.9e-02 1.1e-01 1.0e-01 1.4e-01
11 Brain isoform ratio XM_039103939.2 0.03 0.03 4.3e-03 0.02 0.01 0.01 0.01 4.5e-03 1.8e-02 1.3e-02 1.8e-02
12 Brain gene expression Ercc1 0.07 0.06 1.8e-06 0.06 0.06 0.05 0.04 6.0e-06 7.4e-06 2.9e-05 4.6e-05
13 NAcc gene expression Ercc1 0.04 0.04 4.9e-06 0.03 0.03 0.03 0.03 1.5e-05 2.0e-05 4.9e-05 5.0e-05
14 Brain mRNA stability Ercc1 0.03 0.03 3.7e-03 0.01 0.01 0 0.01 1.9e-02 2.8e-02 9.6e-02 4.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.1-0.2-0.1-0.1-0.00.0-0.0-0.0-0.00.20.2-0.20.10.20.4
Area under the delay curve1.32.12.7-1.4-1.4-1.4-1.4-1.41.41.41.41.41.4-1.4-1.6-1.6-1.5
BMI with tail0.62.02.31.41.51.41.41.4-1.4-1.4-1.4-1.4-1.31.31.51.41.5
BMI without tail0.41.92.21.51.41.41.41.4-1.4-1.4-1.4-1.4-1.41.41.31.41.1
Body weight1.14.95.22.32.32.32.22.2-2.2-2.2-2.2-2.2-2.12.12.22.12.3
Weight adjusted by age0.00.00.00.10.10.10.00.0-0.0-0.0-0.0-0.1-0.10.1-0.0-0.0-0.1
Bone surface0.20.51.10.60.60.60.70.7-0.7-0.7-0.7-0.5-0.50.50.80.81.0
Bone volume0.20.30.80.40.40.40.50.6-0.6-0.6-0.6-0.4-0.40.40.70.80.9
Breakpoint value in progressive ratio session1.52.73.0-1.7-1.7-1.7-1.6-1.61.61.61.61.61.6-1.6-1.6-1.6-1.5
Number of licking bursts1.23.74.92.22.12.11.91.9-1.9-1.9-1.9-2.1-2.12.11.51.51.7
Context. condit. distance diff. score0.10.10.20.40.30.30.40.4-0.4-0.4-0.4-0.3-0.30.30.40.40.4
Locomotion velocity, session 10.10.10.1-0.3-0.3-0.3-0.2-0.20.20.20.20.30.3-0.3-0.4-0.3-0.2
Locomotion distance, session 10.00.10.20.10.10.10.20.2-0.2-0.2-0.2-0.1-0.10.10.40.40.5
Locomotion velocity, session 21.21.41.71.31.21.31.21.2-1.2-1.2-1.2-1.3-1.31.31.01.11.0
Locomotion distance, session 20.30.40.80.50.50.50.60.6-0.6-0.6-0.6-0.5-0.50.50.90.80.9
Locomotion velocity, session 30.20.20.30.50.50.50.50.5-0.5-0.5-0.5-0.5-0.50.50.50.50.3
Locomotion distance, session 30.70.80.9-1.0-0.9-0.9-0.9-0.90.90.90.90.90.9-0.9-0.8-0.8-0.9
Stereotopy head waving bouts, day 30.81.01.51.21.11.11.01.0-1.0-1.0-1.0-1.1-1.11.10.70.70.5
Stereotopy head waving duration, day 31.01.21.61.31.21.21.11.1-1.1-1.1-1.1-1.2-1.21.21.01.00.8
Locomotion velocity, session 70.10.10.2-0.5-0.4-0.4-0.4-0.40.40.40.40.40.4-0.4-0.1-0.1-0.1
Locomotion distance, session 70.00.00.10.20.20.20.20.2-0.2-0.2-0.2-0.2-0.20.20.30.30.3
Stereotopy head waving bouts, day 70.91.01.21.11.01.01.11.1-1.1-1.1-1.1-1.0-1.01.01.01.01.0
Stereotopy head waving duration, day 70.70.91.11.01.01.01.01.0-1.0-1.0-1.0-1.0-1.01.00.80.80.8
Locomotion velocity, session 80.00.00.1-0.0-0.0-0.0-0.1-0.10.10.10.10.00.0-0.0-0.1-0.1-0.2
Locomotion distance, session 80.00.00.2-0.0-0.0-0.00.10.1-0.1-0.1-0.10.00.0-0.00.40.40.3
Degree of sensitization distance0.60.60.70.80.80.80.80.8-0.8-0.8-0.8-0.8-0.80.80.80.80.7
Degree of sensitization stereotypy1.01.11.21.11.01.01.11.1-1.1-1.1-1.1-1.0-1.01.01.01.01.1
Conditioned locomotion0.00.00.1-0.2-0.2-0.2-0.2-0.20.20.20.20.20.2-0.2-0.1-0.2-0.2
Cocaine response after cond. corrected0.50.71.10.80.80.80.90.9-0.9-0.9-0.9-0.8-0.80.81.00.81.0
Cocaine response after cond. not corrected1.31.82.71.31.21.31.31.3-1.3-1.3-1.3-1.3-1.31.31.51.31.6
Cocaine response before conditioning1.61.92.01.41.41.41.41.4-1.4-1.4-1.4-1.4-1.41.41.31.41.3
Saline control response2.02.73.21.81.61.61.71.7-1.7-1.7-1.7-1.7-1.71.71.61.71.5
Bone: connectivity density0.00.10.1-0.4-0.3-0.3-0.2-0.20.20.20.20.40.4-0.40.10.10.2
Bone: cortical apparent density0.10.10.2-0.4-0.4-0.4-0.3-0.30.30.30.30.40.4-0.4-0.1-0.1-0.4
Bone: cortical area1.52.42.81.71.61.61.61.6-1.6-1.6-1.6-1.6-1.61.61.31.51.5
Bone: cortical porosity0.20.20.6-0.3-0.4-0.4-0.4-0.50.50.50.40.30.3-0.3-0.7-0.6-0.8
Bone: cortical porosity0.00.00.20.1-0.0-0.0-0.1-0.10.10.10.1-0.1-0.10.1-0.2-0.2-0.4
Bone: cortical thickness0.61.01.11.11.01.01.01.0-1.0-1.0-1.0-1.0-1.01.00.91.00.8
Bone: cortical thickness1.41.71.81.31.41.41.31.3-1.3-1.3-1.3-1.2-1.21.21.21.41.2
Bone: cortical tissue density0.10.20.3-0.5-0.5-0.5-0.4-0.40.40.40.40.50.5-0.5-0.2-0.2-0.5
Condit. Reinf. active minus inactive responses0.40.50.90.60.60.60.70.7-0.7-0.7-0.7-0.6-0.60.60.80.70.9
Condit. Reinf. active-inactive response ratio0.30.31.10.40.40.40.60.6-0.6-0.6-0.6-0.4-0.40.40.80.71.0
Condit. Reinf. active responses0.20.30.70.40.40.40.50.5-0.5-0.5-0.5-0.4-0.40.40.80.70.7
Condit. Reinf. inactive responses0.00.00.1-0.3-0.2-0.2-0.2-0.10.10.10.10.20.2-0.20.20.1-0.1
Incentive salience index mean0.20.30.50.50.50.40.50.5-0.5-0.5-0.5-0.4-0.40.40.60.60.7
Condit. Reinf. lever presses0.00.00.00.10.10.10.10.1-0.1-0.1-0.1-0.1-0.10.10.20.10.2
Condit. Reinf. active minus inactive responses0.10.10.30.30.30.30.30.3-0.3-0.3-0.3-0.3-0.30.30.40.40.5
Condit. Reinf. active-inactive response ratio0.40.61.20.70.60.60.70.7-0.7-0.7-0.7-0.7-0.70.70.90.81.1
Condit. Reinf. active responses0.10.10.2-0.3-0.2-0.2-0.3-0.30.30.30.30.30.3-0.3-0.3-0.3-0.4
Condit. Reinf. inactive responses0.71.02.0-1.0-0.9-0.9-1.0-1.01.01.01.00.90.9-0.9-1.0-1.0-1.4
Condit. Reinf. lever presses0.10.20.30.40.50.50.40.4-0.4-0.4-0.4-0.5-0.50.50.40.40.5
Condit. Reinf. lever reinforcers received0.10.10.2-0.3-0.3-0.3-0.3-0.30.30.30.30.30.3-0.3-0.4-0.4-0.4
Conditioned reinforcement - actives0.62.22.31.51.51.51.51.5-1.5-1.5-1.5-1.4-1.41.41.51.51.5
Conditioned reinforcement - inactives0.20.50.70.80.70.70.70.7-0.7-0.7-0.7-0.8-0.80.80.70.70.5
Conditioned locomotion2.03.03.21.81.81.81.81.8-1.8-1.7-1.7-1.7-1.71.71.71.71.8
Patch foraging indifference point 0 sec0.30.70.80.90.90.90.90.9-0.9-0.9-0.9-0.8-0.80.80.80.80.8
Patch foraging indifference point AUC1.84.25.12.32.12.22.12.0-2.0-2.0-2.0-2.2-2.22.21.92.01.6
Delay disc. indifference point, 0s delay1.41.61.7-1.3-1.2-1.2-1.2-1.21.21.21.21.21.2-1.2-1.3-1.3-1.3
Delay disc. indifference point, 16s delay0.91.31.6-1.2-1.1-1.1-1.1-1.11.11.11.11.11.1-1.1-1.2-1.2-1.0
Delay disc. indifference point, 2s delay3.74.25.7-1.9-1.9-1.9-2.0-2.12.12.12.01.91.9-1.9-2.4-2.4-2.3
Delay disc. indifference point, 24s delay0.10.10.30.20.20.20.20.2-0.3-0.3-0.3-0.2-0.20.20.30.30.6
Delay disc. indifference point, 4s delay0.00.00.10.00.00.0-0.1-0.10.10.10.1-0.0-0.00.0-0.2-0.2-0.2
Delay disc. indifference point, 8s delay1.22.02.4-1.4-1.4-1.4-1.4-1.41.41.41.41.41.4-1.4-1.6-1.6-1.4
Indifference point function ln k0.51.41.8-1.3-1.3-1.3-1.1-1.11.11.11.11.31.3-1.3-1.0-1.0-0.8
Indifference point function log k0.51.41.8-1.3-1.3-1.3-1.1-1.11.11.11.11.31.3-1.3-1.0-1.0-0.8
Patch foraging total patch changes 0 sec0.41.11.21.11.11.01.11.1-1.1-1.1-1.1-1.0-1.01.01.11.11.1
Patch foraging total patch changes 12 sec1.31.72.21.51.41.41.31.3-1.3-1.3-1.3-1.4-1.41.41.21.11.1
Patch foraging total patch changes 18 sec1.22.93.41.81.61.61.71.7-1.7-1.7-1.7-1.6-1.61.61.81.71.8
Patch foraging total patch changes 24 sec0.10.40.60.70.60.60.70.7-0.7-0.7-0.7-0.6-0.60.60.80.60.8
Patch foraging total patch changes 6 sec2.23.74.22.11.92.01.91.9-1.9-1.9-1.9-1.9-1.91.91.92.01.6
Patch foraging time to switch 0 sec1.45.46.6-2.3-2.3-2.3-2.3-2.42.42.32.32.22.2-2.2-2.6-2.4-2.2
Patch foraging water rate 0 sec1.66.16.62.52.52.42.52.5-2.5-2.5-2.5-2.4-2.42.42.62.62.3
Patch foraging water rate 12 sec0.10.30.70.40.40.40.50.5-0.5-0.5-0.5-0.4-0.40.40.70.70.8
Patch foraging water rate 18 sec0.10.20.30.40.30.30.40.5-0.5-0.5-0.4-0.3-0.30.30.60.60.5
Patch foraging water rate 24 sec0.60.81.00.90.90.90.90.9-0.9-0.9-0.9-0.8-0.80.81.01.00.8
Patch foraging water rate 6 sec0.71.01.60.90.90.91.01.0-1.0-1.0-1.0-0.9-0.90.91.21.31.1
Seeking ratio, delayed vs. immediate footshock1.62.42.8-1.7-1.6-1.6-1.5-1.51.51.51.51.61.6-1.6-1.4-1.4-1.4
Distance traveled before self-admin0.10.10.20.40.30.30.30.3-0.3-0.3-0.3-0.3-0.30.30.20.20.5
Distance traveled after self-admin0.10.20.2-0.4-0.4-0.4-0.4-0.40.40.40.40.40.4-0.4-0.5-0.4-0.5
Extensor digitorum longus weight1.76.87.72.82.52.52.72.7-2.7-2.7-2.7-2.6-2.62.62.42.52.7
Bone: elastic displacement1.01.31.7-1.2-1.3-1.3-1.1-1.11.11.11.11.21.2-1.2-1.0-1.0-1.1
Bone: elastic work0.00.00.10.10.00.00.10.1-0.1-0.1-0.1-0.1-0.10.10.10.20.0
Bone: endosteal estimation0.00.00.1-0.3-0.3-0.3-0.2-0.20.20.20.20.20.2-0.2-0.2-0.20.1
Bone: endosteal perimeter0.00.00.00.00.00.0-0.0-0.00.00.00.0-0.1-0.10.1-0.1-0.10.1
Epididymis fat weight0.20.81.1-0.9-0.8-0.8-0.9-0.90.90.90.90.90.9-0.9-1.0-1.0-1.0
Delta time in closed arm before/after self-admin0.10.10.2-0.5-0.3-0.3-0.3-0.30.30.30.30.40.4-0.4-0.1-0.2-0.3
Delta time in open arm before/after self-admin0.00.00.1-0.1-0.2-0.2-0.2-0.20.20.20.20.10.1-0.1-0.2-0.1-0.4
Diff in mean of infusions in LGA sessions0.91.71.8-1.3-1.3-1.3-1.3-1.31.31.31.31.31.3-1.3-1.3-1.2-1.1
Delay discount exponential model param1.11.52.01.21.11.11.21.2-1.2-1.2-1.2-1.1-1.11.11.41.41.2
Extinction: sum of active levers before priming0.00.10.2-0.3-0.3-0.3-0.3-0.30.30.30.30.20.2-0.2-0.2-0.1-0.4
Active lever presses in extinction session 60.10.10.20.30.20.20.30.3-0.3-0.3-0.3-0.2-0.20.20.20.40.5
Bone: final force0.30.60.70.80.80.80.80.8-0.8-0.8-0.8-0.8-0.80.80.60.70.7
Bone: final moment0.50.81.01.01.01.00.90.9-0.9-0.9-0.9-0.9-0.90.90.70.80.8
Food consumed during 24 hour testing period3.57.08.5-2.9-2.7-2.8-2.6-2.62.62.62.62.82.8-2.8-2.4-2.4-2.4
Glucose0.20.40.7-0.6-0.5-0.5-0.6-0.60.70.60.60.50.5-0.5-0.8-0.8-0.7
Heart weight2.23.54.12.01.91.91.91.9-1.9-1.9-1.9-1.9-1.91.91.71.81.8
Delay discount hyperbolic model param1.01.31.91.11.01.01.11.2-1.2-1.2-1.2-1.0-1.01.01.41.41.2
Intermittent access intake day 1-15 change0.00.20.20.40.40.40.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.3
Intermittent access intake escalation0.00.20.30.50.50.50.50.5-0.5-0.5-0.5-0.5-0.50.50.50.50.4
Intermittent access intake escalation 20.00.00.00.10.10.10.10.1-0.1-0.1-0.1-0.1-0.10.10.10.10.1
Intermitt. access day 1 inactive lever presses0.00.00.00.10.00.00.10.1-0.1-0.1-0.1-0.1-0.10.10.00.00.1
Intermitt. access day 15 inactive lever presses0.00.00.00.00.00.00.00.0-0.0-0.0-0.0-0.0-0.00.00.00.0-0.0
Intermitt. access escalation Index0.10.30.4-0.6-0.6-0.6-0.5-0.50.50.50.50.60.6-0.6-0.5-0.5-0.4
Intermittent access day 1 total infusions0.82.32.71.61.51.51.51.5-1.5-1.5-1.5-1.5-1.51.51.51.51.2
Intermittent access day 15 total infusions0.41.11.21.11.11.11.01.0-1.0-1.0-1.0-1.1-1.11.11.01.00.8
Intermittent access terminal intake (last 3 days)0.91.51.71.31.31.31.21.2-1.2-1.2-1.2-1.2-1.21.21.21.21.0
Intermittent access total infusions2.52.93.21.81.71.71.71.7-1.7-1.7-1.7-1.7-1.71.71.71.71.5
Intermittent access day 1 locomotion0.20.40.40.60.60.60.60.6-0.6-0.6-0.6-0.6-0.60.60.60.60.7
Intermittent access day 15 total locomotion0.10.20.30.50.50.50.50.5-0.5-0.5-0.5-0.5-0.50.50.50.50.3
Intermittent access total locomotion1.62.02.21.51.41.41.41.4-1.4-1.4-1.4-1.4-1.41.41.41.41.2
Intermittent access standard deviation0.00.20.3-0.4-0.4-0.4-0.5-0.50.50.50.50.40.4-0.4-0.5-0.5-0.6
Left kidney weight3.326.328.95.35.15.15.15.1-5.1-5.1-5.1-5.0-5.05.05.45.35.2
Right kidney weight3.423.725.45.04.84.84.94.9-4.9-4.9-4.9-4.8-4.74.75.04.94.9
Cocaine induced anxiety0.10.30.7-0.5-0.6-0.6-0.5-0.50.50.50.50.50.5-0.5-0.6-0.6-0.8
Post-drug Anxiety0.10.10.2-0.1-0.3-0.3-0.2-0.20.20.20.20.10.1-0.1-0.3-0.3-0.5
Baseline Anxiety0.00.00.00.10.00.00.00.0-0.0-0.0-0.0-0.1-0.10.10.00.00.1
Tail length0.21.31.61.31.21.21.11.1-1.1-1.1-1.1-1.2-1.21.21.01.10.9
Length with tail0.31.31.51.21.21.21.21.2-1.2-1.2-1.2-1.1-1.11.11.11.11.1
Length without tail0.21.22.21.01.01.01.11.1-1.1-1.1-1.1-0.9-0.90.91.21.01.5
Times rat made contact with spout0.00.00.2-0.2-0.2-0.2-0.0-0.00.00.00.00.20.2-0.20.20.20.4
Lifetime Intake2.32.83.21.81.71.71.71.7-1.7-1.7-1.7-1.7-1.71.71.71.71.4
Liver weight, left1.93.33.92.01.91.91.91.8-1.8-1.8-1.8-1.8-1.81.81.61.71.5
Liver weight, right1.22.12.71.41.41.41.51.5-1.5-1.5-1.5-1.4-1.41.41.61.61.5
Locomotor activity2.23.54.52.12.02.01.91.8-1.8-1.8-1.8-2.0-2.02.01.71.71.1
Locomotor testing distance0.82.12.81.71.51.51.51.4-1.4-1.4-1.4-1.5-1.51.51.31.40.7
Locomotor testing rearing2.48.710.13.23.03.03.02.9-2.9-2.9-2.9-3.0-3.03.02.92.82.5
Locomotion in novel chamber0.10.10.2-0.3-0.3-0.3-0.4-0.40.40.40.40.30.3-0.3-0.4-0.4-0.4
Locomotion in novel chamber post-restriction0.51.52.0-1.4-1.2-1.3-1.1-1.21.21.21.21.31.3-1.3-1.1-1.1-1.4
Fecal boli incidents, locomotor time 10.00.00.10.30.20.20.20.2-0.2-0.2-0.2-0.2-0.20.20.10.10.1
Change in fecal boli incidents, locomotor task0.80.91.2-0.9-0.9-0.9-0.9-0.90.90.90.90.90.9-0.9-1.1-1.1-1.1
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.1-0.10.00.0-0.0-0.0-0.00.10.1-0.10.30.30.3
Bouts of movement, locomotor time 12.02.63.0-1.7-1.7-1.7-1.6-1.61.61.61.61.71.7-1.7-1.5-1.5-1.4
Total resting periods, locomotor time 12.93.43.7-1.9-1.9-1.9-1.9-1.81.81.81.81.91.9-1.9-1.7-1.7-1.7
Rest time, locomotor task time 10.10.20.2-0.5-0.5-0.5-0.5-0.50.40.50.50.50.5-0.5-0.3-0.3-0.4
Distance moved, locomotor task time 10.20.50.60.80.80.80.70.7-0.7-0.7-0.7-0.8-0.80.80.50.50.6
Vertical activity count, locomotor time 10.00.00.1-0.0-0.0-0.0-0.1-0.10.10.10.10.00.0-0.0-0.3-0.3-0.2
Time >=10cm from walls, locomotor time 20.00.10.2-0.3-0.2-0.2-0.3-0.30.30.30.30.20.2-0.2-0.4-0.4-0.3
Bouts of movement, locomotor time 22.16.98.1-2.9-2.7-2.7-2.7-2.62.62.62.62.72.7-2.7-2.5-2.5-2.1
Total resting periods, locomotor time 21.56.07.2-2.7-2.5-2.5-2.5-2.52.52.52.52.52.5-2.5-2.3-2.3-1.9
Rest time, locomotor task time 20.00.00.1-0.2-0.3-0.3-0.2-0.10.10.10.20.30.3-0.30.10.1-0.1
Distance moved, locomotor task time 20.70.91.11.01.01.00.90.9-0.9-0.9-0.9-1.0-1.01.00.60.61.0
Vertical activity count, locomotor time 20.10.10.4-0.3-0.2-0.2-0.3-0.30.30.30.30.20.2-0.2-0.6-0.6-0.4
Light reinforcement 10.00.10.40.30.20.20.40.4-0.4-0.4-0.4-0.3-0.30.30.40.60.5
Light reinforcement 20.00.10.20.30.20.30.30.3-0.3-0.3-0.3-0.3-0.30.30.30.50.2
Bone: marrow area0.00.00.1-0.2-0.2-0.2-0.2-0.20.20.20.20.10.1-0.1-0.2-0.10.2
Bone: maximum diameter2.14.34.82.22.12.12.02.0-2.0-2.0-2.0-2.1-2.12.12.02.02.1
Bone: maximum force0.10.30.40.50.60.60.50.5-0.5-0.5-0.5-0.5-0.50.50.30.50.4
Bone: maximum moment0.20.40.50.70.70.70.60.6-0.6-0.6-0.6-0.7-0.70.70.40.50.5
Mean time between licks in bursts0.00.10.1-0.3-0.3-0.3-0.3-0.30.30.30.30.30.3-0.3-0.4-0.3-0.3
Mean num. licks in bursts1.43.75.3-2.3-2.2-2.2-1.9-1.91.91.91.92.22.2-2.2-1.3-1.3-1.4
Cd content in liver0.00.10.1-0.3-0.3-0.3-0.2-0.10.10.10.20.30.3-0.30.1-0.10.4
Co content in liver1.21.51.8-1.3-1.2-1.2-1.2-1.21.21.21.21.21.2-1.2-1.2-1.4-1.0
Cu content in liver0.30.30.50.70.60.60.60.6-0.6-0.6-0.6-0.6-0.60.60.50.30.6
Fe content in liver4.85.97.42.72.62.62.42.4-2.4-2.4-2.4-2.6-2.62.61.92.12.0
K content in liver0.10.10.20.40.40.40.30.3-0.3-0.3-0.3-0.4-0.40.40.2-0.00.2
Mg content in liver0.40.50.70.80.80.80.70.7-0.7-0.7-0.7-0.8-0.80.80.60.40.4
Mn content in liver0.91.01.11.11.01.01.01.0-1.0-1.0-1.0-1.0-1.01.01.10.91.0
Na content in liver0.10.20.30.60.40.40.40.4-0.4-0.4-0.4-0.4-0.40.40.10.20.2
Rb content in liver0.10.10.40.20.20.20.40.4-0.4-0.4-0.4-0.2-0.20.20.60.40.6
Se content in liver3.64.25.52.32.22.22.12.1-2.0-2.1-2.1-2.2-2.22.21.71.81.5
Sr content in liver0.00.00.10.20.20.20.10.1-0.1-0.1-0.1-0.2-0.20.2-0.10.2-0.1
Zn content in liver0.70.81.31.00.90.90.90.9-0.9-0.9-0.9-0.9-0.90.90.80.71.1
Bone: minimum diameter0.20.30.40.60.50.50.60.6-0.6-0.6-0.6-0.6-0.60.60.40.50.6
Time in familiar zone, hab. session 10.20.20.20.50.50.50.40.4-0.4-0.4-0.4-0.5-0.50.50.30.30.4
Time in novel zone, hab. session 10.50.60.60.80.80.80.70.7-0.7-0.7-0.7-0.8-0.80.80.70.60.7
Total zone transitions, hab. session 10.20.30.50.40.40.40.50.5-0.5-0.5-0.5-0.4-0.40.40.70.70.6
Total locomotion distance, hab. session 10.40.60.7-0.8-0.7-0.7-0.7-0.70.70.70.70.70.7-0.7-0.8-0.7-0.8
Locomotion velocity, hab. session 11.31.81.9-1.4-1.3-1.3-1.3-1.31.31.31.31.31.3-1.3-1.3-1.3-1.4
Time in familiar zone, hab. session 20.20.20.30.60.50.50.50.5-0.5-0.5-0.5-0.5-0.50.50.30.30.2
Time in novel zone, hab. session 20.00.00.1-0.2-0.2-0.2-0.2-0.20.20.20.20.20.2-0.2-0.1-0.20.1
Total zone transitions, hab. session 20.50.60.80.90.80.80.80.8-0.8-0.8-0.8-0.8-0.80.80.60.70.7
Total locomotion distance, hab. session 20.60.71.0-0.9-0.8-0.8-0.8-0.80.80.80.80.80.8-0.8-1.0-1.0-0.9
Locomotion velocity, hab. session 20.40.50.6-0.7-0.7-0.7-0.7-0.70.70.70.70.70.7-0.7-0.8-0.7-0.7
Novel to familiar place preference ratio0.70.92.00.70.70.70.90.9-0.9-0.9-0.9-0.7-0.70.71.31.31.4
Novelty place preference0.60.81.70.70.70.70.80.9-0.9-0.9-0.9-0.7-0.70.71.21.21.3
Time in novel zone, NPP test0.81.01.90.80.80.80.91.0-1.0-1.0-1.0-0.8-0.80.81.31.21.4
Total zone transitions, NPP test0.10.20.20.40.40.40.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.4
Total locomotion distance, NPP test0.10.10.20.40.40.40.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.4
Locomotion velocity, NPP test0.10.10.20.30.30.30.30.3-0.3-0.3-0.3-0.3-0.30.30.40.40.4
Intraocular pressure0.00.00.0-0.1-0.0-0.1-0.0-0.00.00.00.00.00.0-0.0-0.1-0.20.2
Delta distance traveled before/after self-admin1.92.02.6-1.5-1.4-1.4-1.4-1.41.41.41.41.41.4-1.4-1.4-1.2-1.6
Delta ambulatory time before/after self-admin0.30.50.8-0.7-0.7-0.7-0.7-0.70.70.70.70.70.7-0.7-0.7-0.6-0.9
Parametrial fat weight0.10.20.30.50.40.40.40.4-0.4-0.4-0.4-0.5-0.40.40.50.40.3
Pavlov. Cond. lever latency0.50.60.7-0.7-0.7-0.7-0.8-0.80.80.80.80.70.7-0.7-0.8-0.8-0.9
Pavlov. Cond. magazine entry latency0.10.10.20.20.20.20.30.3-0.3-0.3-0.3-0.2-0.20.20.30.20.5
Pavlov. Cond. change in total contacts0.60.60.9-0.9-0.8-0.8-0.8-0.80.80.80.80.80.8-0.8-0.6-0.7-0.4
Pavlov. Cond. index score0.20.30.50.50.50.50.50.5-0.5-0.5-0.5-0.5-0.50.50.60.50.7
Pavlov. Cond. latency score0.00.00.10.20.20.20.20.2-0.2-0.2-0.2-0.2-0.20.20.20.10.3
Pavlov. Cond. lever contacts0.30.30.50.50.50.50.60.6-0.6-0.6-0.6-0.5-0.50.50.60.60.7
Pavlov. Cond. magazine entry number0.00.00.1-0.0-0.0-0.0-0.1-0.10.10.10.10.00.0-0.0-0.10.0-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.20.30.30.30.30.3-0.3-0.3-0.3-0.3-0.30.30.50.40.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.50.50.50.60.6-0.6-0.6-0.6-0.5-0.50.50.60.50.7
Pavlov. Cond. response bias0.81.01.60.90.90.91.01.0-1.0-1.0-1.0-0.9-0.90.91.11.01.3
Pavlov. Cond. lever latency0.00.00.1-0.2-0.2-0.2-0.1-0.10.10.10.10.20.2-0.2-0.0-0.0-0.3
Pavlov. Cond. magazine entry latency0.10.11.00.00.10.10.20.2-0.2-0.2-0.2-0.1-0.10.10.50.41.0
Pavlov. Cond. change in total contacts0.10.20.3-0.5-0.5-0.4-0.4-0.40.40.40.40.50.5-0.5-0.4-0.40.1
Pavlov. Cond. index score0.00.00.2-0.2-0.1-0.1-0.1-0.10.10.10.10.10.1-0.10.1-0.00.5
Pavlov. Cond. latency score0.00.10.1-0.3-0.3-0.3-0.2-0.20.20.20.20.30.3-0.3-0.1-0.20.3
Pavlov. Cond. lever contacts0.10.10.30.30.40.40.30.3-0.3-0.3-0.3-0.3-0.30.30.30.30.5
Pavlov. Cond. magazine entry number0.20.30.50.70.60.60.60.5-0.5-0.5-0.5-0.6-0.60.60.30.5-0.2
Pavlov. Cond. intertrial magazine entries0.00.00.20.10.10.10.00.0-0.0-0.0-0.0-0.0-0.00.00.10.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.40.00.00.10.10.1-0.1-0.1-0.1-0.0-0.00.00.20.20.6
Pavlov. Cond. response bias0.00.00.2-0.0-0.00.0-0.0-0.00.00.00.00.00.0-0.00.10.00.5
Time in closed arm before self-admin0.61.11.21.11.01.01.01.0-1.0-1.0-1.0-1.0-1.01.01.01.01.1
Time in closed arm after self-admin0.70.81.0-1.0-0.9-0.9-0.9-0.90.90.90.90.90.9-0.9-0.9-1.0-0.9
Time in open arm before self-admin0.81.01.1-1.0-1.0-1.0-1.0-1.01.01.01.00.90.9-0.9-0.9-1.0-1.0
Time in open arm after self-admin0.10.10.3-0.3-0.4-0.4-0.4-0.40.40.40.40.30.3-0.3-0.4-0.2-0.6
Bone: periosteal estimation0.20.60.80.80.70.70.70.7-0.7-0.7-0.7-0.8-0.80.80.60.70.9
Bone: periosteal perimeter0.20.40.50.70.70.70.70.7-0.7-0.7-0.7-0.7-0.70.70.50.60.7
Bone: post-yield work0.61.01.3-1.1-1.0-1.0-1.0-1.01.01.01.01.01.0-1.0-1.0-0.9-0.9
Progressive ratio test 1 active lever presses1.83.13.51.91.81.81.81.8-1.8-1.8-1.8-1.8-1.81.81.81.81.5
Progressive ratio test 1 breakpoint1.62.73.11.81.71.71.71.7-1.7-1.7-1.7-1.7-1.71.71.71.71.4
Progressive ratio test 1 inactive lever presses0.71.92.21.51.41.41.41.4-1.4-1.4-1.4-1.4-1.41.41.31.31.1
Progressive ratio test 2 active lever presses1.82.53.11.81.61.61.61.6-1.6-1.6-1.6-1.7-1.71.71.51.51.3
Progressive ratio test 2 breakpoint2.22.83.51.91.71.71.71.7-1.7-1.7-1.7-1.7-1.71.71.61.61.4
Progressive ratio test 2 inactive lever presses0.10.20.30.50.40.40.40.4-0.4-0.4-0.4-0.5-0.50.50.30.30.2
Incentive Sensitization - Responses0.51.51.91.41.21.21.21.2-1.2-1.2-1.2-1.3-1.31.31.11.11.1
Incentive Sensitization - Breakpoint0.61.31.71.31.11.11.21.2-1.2-1.2-1.2-1.2-1.21.21.11.11.1
Sum of active levers in priming session hrs 5-60.30.30.4-0.5-0.5-0.5-0.5-0.50.50.50.50.50.5-0.5-0.5-0.4-0.6
Progressive ratio0.61.82.1-1.5-1.4-1.4-1.3-1.31.31.31.31.41.4-1.4-1.3-1.2-1.4
Food seeking constrained by brief footshock5.16.36.9-2.6-2.5-2.5-2.6-2.62.52.62.62.52.5-2.5-2.5-2.5-2.4
Seeking ratio, punishment vs. effort0.30.70.8-0.8-0.8-0.8-0.9-0.90.90.90.90.80.8-0.8-0.7-0.8-0.8
Retroperitoneal fat weight0.00.10.20.40.40.40.30.3-0.3-0.3-0.3-0.4-0.30.30.30.30.2
Reaction time number correct2.17.48.52.92.82.72.82.8-2.8-2.8-2.8-2.7-2.72.72.82.72.3
Reaction time mean minus median0.00.10.1-0.4-0.3-0.3-0.3-0.30.30.30.30.30.3-0.3-0.2-0.20.0
Reaction time mean minus median AUC0.00.20.80.40.40.40.40.5-0.5-0.4-0.4-0.4-0.40.40.60.50.9
Reaction time num false alarms3.56.07.52.52.42.42.52.5-2.5-2.5-2.5-2.4-2.42.42.52.52.7
Reaction time num false alarms AUC2.25.16.22.42.22.22.32.3-2.3-2.3-2.3-2.2-2.22.22.22.22.5
Reaction time trials correct on left2.17.48.52.92.82.72.82.8-2.8-2.8-2.8-2.7-2.72.72.82.72.3
Reaction time trials on left2.27.48.42.92.72.72.82.8-2.8-2.8-2.8-2.7-2.72.72.82.72.3
Reaction time mean0.71.62.2-1.5-1.4-1.4-1.3-1.31.31.31.31.31.3-1.3-1.0-1.0-0.7
Reaction time mean AUC0.51.21.6-1.3-1.2-1.2-1.1-1.11.11.11.11.21.2-1.2-0.9-0.9-0.5
Median of all reaction times1.32.02.6-1.6-1.5-1.5-1.5-1.51.51.51.51.51.5-1.5-1.1-1.2-0.9
Reaction time omissions0.00.00.2-0.10.0-0.00.10.1-0.1-0.1-0.10.00.0-0.00.30.20.4
Reaction time false alarm rate0.10.20.50.40.40.40.40.4-0.4-0.4-0.4-0.4-0.40.40.30.40.7
Reaction time premature initiation rate0.40.60.8-0.9-0.9-0.9-0.8-0.80.80.80.80.80.8-0.8-0.6-0.6-0.7
Reaction time premature initiations0.10.40.70.60.50.50.70.7-0.7-0.7-0.7-0.6-0.60.60.80.70.6
Std. dev. reaction times0.10.20.3-0.6-0.5-0.5-0.5-0.50.50.50.50.50.5-0.5-0.4-0.5-0.1
Reaction time trials completed2.27.48.42.92.72.72.82.8-2.8-2.8-2.8-2.7-2.72.72.82.72.3
Reaction time trials AUC2.69.010.13.23.03.03.03.0-3.0-3.0-3.0-3.0-3.03.03.13.02.6
Run reversals in cocaine runway, females0.20.20.3-0.6-0.4-0.4-0.5-0.50.50.50.50.50.5-0.5-0.5-0.5-0.3
Run reversals in cocaine runway, males0.40.50.50.70.70.70.70.7-0.7-0.7-0.7-0.7-0.70.70.70.70.7
Latency to leave start box in cocaine runway0.10.10.30.10.30.20.30.3-0.3-0.3-0.3-0.1-0.10.10.60.60.4
Latency to leave start box in cocaine runway, F0.70.81.10.81.00.90.90.9-0.9-0.9-0.9-0.8-0.80.81.01.00.9
Latency to leave start box in cocaine runway, M0.10.10.2-0.4-0.4-0.4-0.3-0.30.30.30.30.40.4-0.4-0.1-0.1-0.1
Std. dev. time between licks in bursts0.00.00.10.0-0.0-0.00.10.1-0.1-0.1-0.10.00.0-0.00.30.40.3
Total sessions with >9 infusions3.74.55.12.32.22.22.12.1-2.1-2.1-2.1-2.1-2.12.12.12.11.8
Short access day 1 total inactive lever presses0.30.60.70.90.70.70.80.8-0.8-0.8-0.8-0.8-0.80.80.70.70.7
Short access day 10 total inactive lever presses0.21.41.6-1.2-1.2-1.2-1.2-1.21.21.21.21.11.1-1.1-1.2-1.2-1.0
Short access day 1 total infusions1.22.52.81.71.61.61.61.6-1.6-1.6-1.6-1.6-1.61.61.61.61.3
Short access day 10 total infusions2.84.65.12.32.22.22.22.1-2.1-2.1-2.1-2.1-2.12.12.12.11.9
Short access total infusions1.92.73.11.81.71.71.71.7-1.7-1.7-1.7-1.7-1.71.71.61.61.3
Short access day 1 locomotion2.43.94.22.12.02.02.02.0-2.0-2.0-2.0-2.0-2.02.02.02.01.7
Short access day 10 total locomotion0.00.00.20.00.10.10.10.1-0.1-0.1-0.1-0.0-0.00.00.10.10.5
Short access total locomotion0.60.91.01.01.01.01.01.0-1.0-1.0-1.0-0.9-0.90.91.01.01.0
One hour access (0.3 mA shock)0.00.00.10.20.20.20.20.2-0.2-0.2-0.2-0.2-0.20.20.20.20.1
Compulsive drug intake0.20.30.60.50.60.60.50.5-0.5-0.5-0.5-0.5-0.50.50.60.60.7
One hour access (shock baseline)0.51.21.51.21.11.11.11.1-1.1-1.1-1.1-1.1-1.11.11.11.10.9
Social response proportion1.01.32.51.01.01.01.11.1-1.1-1.1-1.1-1.0-1.01.01.31.41.6
Social responses0.91.21.61.11.01.11.11.1-1.1-1.1-1.1-1.0-1.01.01.11.21.3
Social time2.84.45.1-2.3-2.1-2.1-2.1-2.12.12.12.12.12.1-2.1-2.1-2.0-1.9
Soleus weight0.10.40.50.60.50.50.60.6-0.6-0.6-0.6-0.6-0.60.60.60.70.6
Bone: stiffness0.71.31.61.21.21.21.11.1-1.1-1.1-1.1-1.2-1.21.20.90.91.0
Tibialis anterior weight3.311.312.33.43.23.23.43.4-3.4-3.4-3.4-3.2-3.23.23.53.53.5
Time to tail flick, vehicle, before self-admin2.43.03.41.81.81.81.81.7-1.7-1.7-1.7-1.8-1.81.81.61.81.5
Time to tail flick, vehicle, after self-admin0.00.00.00.20.10.20.10.1-0.1-0.1-0.1-0.2-0.20.20.10.00.0
Time to tail flick, test, before self-admin0.40.50.6-0.7-0.7-0.7-0.7-0.70.70.70.70.70.7-0.7-0.6-0.6-0.6
Time to tail flick, test, after self-admin0.20.20.4-0.5-0.4-0.4-0.5-0.50.50.50.50.40.4-0.4-0.5-0.6-0.6
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.3-0.3-0.3-0.3-0.30.30.30.30.30.3-0.3-0.2-0.4-0.2
Delta time to tail flick, test, before/after SA0.70.81.01.01.01.00.90.9-0.9-0.9-0.9-1.0-1.01.00.70.80.7
Tibia length0.20.60.80.70.80.80.70.8-0.8-0.8-0.8-0.8-0.80.80.90.70.9
Ambulatory time before self-admin0.00.00.00.0-0.0-0.0-0.0-0.00.00.00.00.00.0-0.0-0.1-0.10.2
Ambulatory time after self-admin0.30.50.6-0.7-0.7-0.7-0.7-0.70.70.70.70.70.7-0.7-0.8-0.6-0.6
Bone: tissue strength0.80.90.9-1.0-0.9-0.9-0.9-0.90.90.90.90.90.9-0.9-0.9-0.9-0.9
Total heroin consumption0.00.00.0-0.1-0.1-0.1-0.1-0.10.10.10.10.10.1-0.1-0.1-0.1-0.2
Bone: trabecular number0.00.10.2-0.4-0.3-0.3-0.2-0.20.20.20.20.40.4-0.4-0.00.00.0
Bone: trabecular spacing0.00.00.10.30.20.20.20.2-0.2-0.2-0.2-0.3-0.30.30.0-0.10.2
Bone: trabecular thickness1.31.82.31.31.31.31.31.3-1.3-1.3-1.3-1.3-1.31.31.41.51.4
Bone: trabecular tissue density0.30.50.70.70.70.70.70.7-0.7-0.7-0.7-0.8-0.80.80.80.70.6
Water consumed over 24 hours0.10.20.3-0.5-0.5-0.5-0.4-0.40.30.40.40.50.5-0.5-0.1-0.10.1
Number of responses in last shaping day2.53.33.61.91.91.91.81.8-1.8-1.8-1.8-1.8-1.81.81.81.81.8