Erbb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL alternative TSS NM_017003.2 0.16 0.11 1.8e-03 0.13 0.09 0.11 0.12 5.1e-04 3.9e-03 1.5e-03 7.9e-04
2 Adipose gene expression Erbb2 0.12 0.08 1.7e-04 0.01 0.02 0.01 0.02 2.8e-02 3.3e-03 9.5e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.42.44.4-2.10.6
Area under the delay curve0.10.10.2-0.4-0.2
BMI with tail1.65.18.02.81.5
BMI without tail0.10.30.50.7-0.2
Body weight2.611.120.04.51.5
Weight adjusted by age0.60.61.00.61.0
Bone surface0.30.61.1-0.21.0
Bone volume0.91.52.5-0.71.6
Breakpoint value in progressive ratio session0.00.00.10.20.1
Number of licking bursts0.70.91.5-0.51.2
Context. condit. distance diff. score1.31.52.01.0-1.4
Locomotion velocity, session 10.20.30.40.60.4
Locomotion distance, session 11.21.61.91.41.1
Locomotion velocity, session 20.30.40.40.6-0.6
Locomotion distance, session 20.60.81.60.11.2
Locomotion velocity, session 30.40.40.8-0.1-0.9
Locomotion distance, session 30.10.10.10.4-0.2
Stereotopy head waving bouts, day 31.01.22.3-1.5-0.4
Stereotopy head waving duration, day 30.00.00.0-0.10.1
Locomotion velocity, session 70.60.61.01.00.5
Locomotion distance, session 70.20.30.60.7-0.0
Stereotopy head waving bouts, day 70.30.30.6-0.80.3
Stereotopy head waving duration, day 70.20.20.4-0.60.1
Locomotion velocity, session 83.74.48.52.9-0.5
Locomotion distance, session 80.40.61.21.10.3
Degree of sensitization distance0.70.71.51.2-0.2
Degree of sensitization stereotypy0.70.71.1-1.10.6
Conditioned locomotion0.60.71.1-0.5-1.1
Cocaine response after cond. corrected1.61.72.6-0.91.6
Cocaine response after cond. not corrected1.71.92.9-1.01.7
Cocaine response before conditioning0.10.10.1-0.2-0.4
Saline control response0.50.71.10.51.1
Bone: connectivity density1.82.95.8-2.40.1
Bone: cortical apparent density3.24.27.9-2.8-0.8
Bone: cortical area0.10.10.1-0.30.3
Bone: cortical porosity0.60.71.2-0.41.1
Bone: cortical porosity0.90.91.8-0.31.3
Bone: cortical thickness0.50.91.6-1.3-0.4
Bone: cortical thickness3.03.56.8-2.6-0.4
Bone: cortical tissue density3.24.27.8-2.8-0.8
Condit. Reinf. active minus inactive responses1.01.11.2-0.9-1.1
Condit. Reinf. active-inactive response ratio1.81.93.1-0.9-1.8
Condit. Reinf. active responses0.70.91.0-1.0-0.8
Condit. Reinf. inactive responses0.30.40.5-0.50.7
Incentive salience index mean0.91.12.0-1.4-0.5
Condit. Reinf. lever presses0.40.50.9-1.00.4
Condit. Reinf. active minus inactive responses0.81.01.6-1.30.7
Condit. Reinf. active-inactive response ratio1.21.21.4-1.21.0
Condit. Reinf. active responses1.62.32.9-1.71.3
Condit. Reinf. inactive responses1.51.82.5-1.61.1
Condit. Reinf. lever presses0.10.10.1-0.40.1
Condit. Reinf. lever reinforcers received1.42.02.9-1.71.0
Conditioned reinforcement - actives0.60.60.8-0.90.6
Conditioned reinforcement - inactives1.51.63.3-1.8-0.0
Conditioned locomotion0.30.40.4-0.70.6
Patch foraging indifference point 0 sec1.11.72.6-1.6-0.9
Patch foraging indifference point AUC0.00.00.00.2-0.1
Delay disc. indifference point, 0s delay0.30.30.5-0.70.2
Delay disc. indifference point, 16s delay0.90.91.7-0.3-1.3
Delay disc. indifference point, 2s delay1.31.41.8-1.01.4
Delay disc. indifference point, 24s delay0.40.40.60.4-0.8
Delay disc. indifference point, 4s delay0.70.71.0-1.00.6
Delay disc. indifference point, 8s delay0.20.20.3-0.4-0.5
Indifference point function ln k0.30.50.80.3-0.9
Indifference point function log k0.30.50.80.3-0.9
Patch foraging total patch changes 0 sec0.91.41.8-1.4-1.0
Patch foraging total patch changes 12 sec3.24.17.9-2.80.6
Patch foraging total patch changes 18 sec0.30.30.6-0.8-0.3
Patch foraging total patch changes 24 sec1.11.32.2-1.5-0.7
Patch foraging total patch changes 6 sec1.01.53.1-1.8-0.1
Patch foraging time to switch 0 sec0.00.10.1-0.30.1
Patch foraging water rate 0 sec0.00.10.1-0.4-0.0
Patch foraging water rate 12 sec0.10.10.20.1-0.4
Patch foraging water rate 18 sec0.60.81.0-1.00.8
Patch foraging water rate 24 sec0.60.91.3-1.10.7
Patch foraging water rate 6 sec1.21.73.3-1.80.3
Seeking ratio, delayed vs. immediate footshock0.30.40.4-0.6-0.6
Distance traveled before self-admin1.21.32.50.31.6
Distance traveled after self-admin1.82.03.71.90.5
Extensor digitorum longus weight5.621.941.16.4-1.6
Bone: elastic displacement0.00.00.00.00.1
Bone: elastic work0.40.50.9-0.50.9
Bone: endosteal estimation1.32.84.12.01.3
Bone: endosteal perimeter0.61.32.41.60.4
Epididymis fat weight0.20.61.10.21.1
Delta time in closed arm before/after self-admin1.61.53.01.7-0.2
Delta time in open arm before/after self-admin0.10.10.20.10.5
Diff in mean of infusions in LGA sessions0.20.20.50.7-0.1
Delay discount exponential model param0.00.00.10.30.1
Extinction: sum of active levers before priming0.80.81.61.3-0.1
Active lever presses in extinction session 63.43.34.7-1.42.2
Bone: final force1.42.23.2-1.11.8
Bone: final moment1.32.03.3-0.91.8
Food consumed during 24 hour testing period0.30.40.60.80.4
Glucose0.30.40.9-0.10.9
Heart weight1.92.75.02.20.6
Delay discount hyperbolic model param0.10.10.10.4-0.0
Intermittent access intake day 1-15 change0.60.61.0-1.0-0.5
Intermittent access intake escalation0.50.51.0-1.0-0.3
Intermittent access intake escalation 20.10.10.2-0.4-0.3
Intermitt. access day 1 inactive lever presses1.51.63.1-1.8-0.1
Intermitt. access day 15 inactive lever presses2.42.75.3-2.3-0.3
Intermitt. access escalation Index1.41.22.31.5-0.4
Intermittent access day 1 total infusions0.80.91.6-0.51.3
Intermittent access day 15 total infusions0.60.61.2-1.10.3
Intermittent access terminal intake (last 3 days)0.80.81.5-1.20.4
Intermittent access total infusions0.60.70.7-0.80.8
Intermittent access day 1 locomotion0.30.30.4-0.40.6
Intermittent access day 15 total locomotion0.60.60.7-0.80.7
Intermittent access total locomotion0.40.50.9-1.00.2
Intermittent access standard deviation2.52.64.3-2.1-1.0
Left kidney weight1.02.84.12.0-1.2
Right kidney weight0.10.30.40.60.3
Cocaine induced anxiety1.21.42.31.50.7
Post-drug Anxiety0.40.40.60.50.8
Baseline Anxiety0.70.71.3-1.1-0.3
Tail length0.30.91.30.7-1.1
Length with tail1.14.17.92.8-0.6
Length without tail1.63.65.92.41.1
Times rat made contact with spout1.21.41.5-1.21.1
Lifetime Intake0.50.60.7-0.80.7
Liver weight, left0.00.00.1-0.30.0
Liver weight, right0.20.40.8-0.9-0.1
Locomotor activity1.22.02.6-1.11.6
Locomotor testing distance1.32.23.9-2.00.7
Locomotor testing rearing3.35.19.5-3.1-0.8
Locomotion in novel chamber3.54.35.5-2.31.7
Locomotion in novel chamber post-restriction2.02.53.8-1.11.9
Fecal boli incidents, locomotor time 10.40.40.50.70.5
Change in fecal boli incidents, locomotor task0.00.00.00.2-0.1
Time >=10cm from walls, locomotor time 10.50.51.0-0.1-1.0
Bouts of movement, locomotor time 10.10.10.20.4-0.3
Total resting periods, locomotor time 10.20.30.50.70.2
Rest time, locomotor task time 10.10.10.1-0.20.3
Distance moved, locomotor task time 10.00.00.0-0.10.1
Vertical activity count, locomotor time 10.40.40.60.40.8
Time >=10cm from walls, locomotor time 20.70.71.4-1.20.3
Bouts of movement, locomotor time 21.11.22.1-0.4-1.5
Total resting periods, locomotor time 21.31.42.7-0.3-1.6
Rest time, locomotor task time 20.30.40.70.8-0.1
Distance moved, locomotor task time 20.20.20.20.40.4
Vertical activity count, locomotor time 20.40.40.60.80.4
Light reinforcement 11.73.26.3-2.50.1
Light reinforcement 21.11.52.1-0.91.4
Bone: marrow area1.22.73.82.01.2
Bone: maximum diameter0.10.10.2-0.20.4
Bone: maximum force0.50.81.60.11.3
Bone: maximum moment0.50.81.50.31.2
Mean time between licks in bursts0.81.12.01.40.4
Mean num. licks in bursts0.10.10.1-0.4-0.3
Cd content in liver0.20.20.3-0.60.3
Co content in liver0.60.70.90.7-0.9
Cu content in liver0.40.50.9-0.3-1.0
Fe content in liver0.60.71.11.10.6
K content in liver0.70.71.4-1.2-0.1
Mg content in liver2.02.02.9-1.1-1.7
Mn content in liver2.02.23.3-1.8-1.1
Na content in liver1.11.22.0-0.61.4
Rb content in liver0.70.81.6-1.3-0.2
Se content in liver3.13.87.4-2.7-0.5
Sr content in liver0.50.50.9-0.3-0.9
Zn content in liver2.12.34.5-2.10.3
Bone: minimum diameter0.40.81.11.10.7
Time in familiar zone, hab. session 13.12.95.5-0.52.3
Time in novel zone, hab. session 12.12.03.6-0.6-1.9
Total zone transitions, hab. session 10.71.01.81.3-0.5
Total locomotion distance, hab. session 10.00.10.1-0.3-0.2
Locomotion velocity, hab. session 10.10.10.10.4-0.3
Time in familiar zone, hab. session 21.21.21.5-0.91.2
Time in novel zone, hab. session 20.60.61.2-0.2-1.1
Total zone transitions, hab. session 20.40.50.90.90.3
Total locomotion distance, hab. session 20.50.71.30.31.1
Locomotion velocity, hab. session 20.40.60.90.51.0
Novel to familiar place preference ratio1.92.02.41.2-1.6
Novelty place preference2.42.53.51.2-1.9
Time in novel zone, NPP test1.71.72.90.8-1.7
Total zone transitions, NPP test0.71.01.90.41.4
Total locomotion distance, NPP test0.81.12.1-0.31.4
Locomotion velocity, NPP test0.50.71.30.31.1
Intraocular pressure1.72.44.82.2-0.1
Delta distance traveled before/after self-admin1.61.72.11.4-1.2
Delta ambulatory time before/after self-admin1.51.61.91.4-1.1
Parametrial fat weight1.73.45.4-2.31.2
Pavlov. Cond. lever latency2.32.92.91.7-1.7
Pavlov. Cond. magazine entry latency5.77.413.0-3.61.4
Pavlov. Cond. change in total contacts4.14.48.6-2.9-0.3
Pavlov. Cond. index score5.26.610.0-3.21.8
Pavlov. Cond. latency score4.15.37.2-2.71.8
Pavlov. Cond. lever contacts2.32.73.2-1.51.8
Pavlov. Cond. magazine entry number7.08.715.94.0-1.3
Pavlov. Cond. intertrial magazine entries1.41.71.81.4-1.3
Pavlov. Cond. lever-magazine prob. diff.5.46.711.1-3.31.5
Pavlov. Cond. response bias5.06.011.2-3.31.0
Pavlov. Cond. lever latency0.60.81.00.8-1.0
Pavlov. Cond. magazine entry latency0.40.51.0-0.01.0
Pavlov. Cond. change in total contacts0.30.40.7-0.80.4
Pavlov. Cond. index score0.70.91.5-0.51.2
Pavlov. Cond. latency score0.60.71.3-0.41.2
Pavlov. Cond. lever contacts1.31.72.3-1.11.5
Pavlov. Cond. magazine entry number0.40.51.00.3-1.0
Pavlov. Cond. intertrial magazine entries2.83.74.71.6-2.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.5-0.41.2
Pavlov. Cond. response bias1.62.12.4-1.41.6
Time in closed arm before self-admin0.50.61.2-0.2-1.1
Time in closed arm after self-admin2.02.03.01.0-1.7
Time in open arm before self-admin0.40.50.80.90.4
Time in open arm after self-admin0.30.30.50.40.7
Bone: periosteal estimation0.40.81.30.61.1
Bone: periosteal perimeter0.61.11.30.91.1
Bone: post-yield work0.81.02.01.40.1
Progressive ratio test 1 active lever presses0.30.40.4-0.70.5
Progressive ratio test 1 breakpoint0.30.30.4-0.60.5
Progressive ratio test 1 inactive lever presses1.01.12.1-1.4-0.4
Progressive ratio test 2 active lever presses1.01.01.8-1.30.5
Progressive ratio test 2 breakpoint0.70.81.3-1.10.5
Progressive ratio test 2 inactive lever presses0.60.71.2-1.10.4
Incentive Sensitization - Responses1.21.22.1-1.40.6
Incentive Sensitization - Breakpoint1.21.21.9-1.40.7
Sum of active levers in priming session hrs 5-60.40.40.6-0.80.5
Progressive ratio0.30.40.7-0.10.9
Food seeking constrained by brief footshock0.20.20.2-0.50.4
Seeking ratio, punishment vs. effort0.20.20.4-0.1-0.6
Retroperitoneal fat weight0.10.40.80.20.9
Reaction time number correct0.81.11.90.61.4
Reaction time mean minus median0.50.60.70.9-0.7
Reaction time mean minus median AUC0.10.10.10.2-0.3
Reaction time num false alarms1.01.41.6-1.11.3
Reaction time num false alarms AUC0.91.31.7-0.91.3
Reaction time trials correct on left0.81.11.90.61.4
Reaction time trials on left0.81.11.90.61.4
Reaction time mean0.71.01.8-0.4-1.3
Reaction time mean AUC0.71.01.8-0.4-1.3
Median of all reaction times1.01.41.5-1.2-1.1
Reaction time omissions0.81.02.0-1.40.3
Reaction time false alarm rate0.50.71.2-1.10.5
Reaction time premature initiation rate0.40.60.7-0.90.6
Reaction time premature initiations0.50.71.4-0.31.2
Std. dev. reaction times0.10.20.30.3-0.6
Reaction time trials completed0.81.11.90.61.4
Reaction time trials AUC0.60.91.40.61.2
Run reversals in cocaine runway, females1.61.51.81.3-1.1
Run reversals in cocaine runway, males0.40.40.6-0.80.5
Latency to leave start box in cocaine runway0.60.71.21.10.4
Latency to leave start box in cocaine runway, F0.91.01.21.10.8
Latency to leave start box in cocaine runway, M0.50.40.7-0.4-0.8
Std. dev. time between licks in bursts0.10.10.20.10.4
Total sessions with >9 infusions0.60.70.9-1.0-0.7
Short access day 1 total inactive lever presses1.71.93.7-1.90.4
Short access day 10 total inactive lever presses0.20.30.5-0.2-0.7
Short access day 1 total infusions0.50.61.1-1.1-0.1
Short access day 10 total infusions0.91.01.5-0.71.2
Short access total infusions0.30.40.7-0.80.2
Short access day 1 locomotion2.22.34.5-2.1-0.3
Short access day 10 total locomotion0.60.61.2-1.10.3
Short access total locomotion0.50.50.7-0.8-0.6
One hour access (0.3 mA shock)0.10.10.1-0.10.3
Compulsive drug intake1.91.93.30.7-1.8
One hour access (shock baseline)1.11.31.9-0.81.4
Social response proportion0.20.30.50.70.3
Social responses0.60.71.4-0.01.2
Social time1.11.42.8-0.21.7
Soleus weight0.51.53.00.31.7
Bone: stiffness0.20.40.7-0.10.9
Tibialis anterior weight0.93.16.02.50.5
Time to tail flick, vehicle, before self-admin0.30.30.6-0.20.8
Time to tail flick, vehicle, after self-admin0.30.30.7-0.20.8
Time to tail flick, test, before self-admin0.40.30.60.8-0.3
Time to tail flick, test, after self-admin1.61.63.2-0.11.8
Delta time to tail flick, vehicle, before/after SA0.80.81.4-0.51.2
Delta time to tail flick, test, before/after SA1.81.62.3-1.01.5
Tibia length1.64.54.72.22.1
Ambulatory time before self-admin0.40.40.80.10.9
Ambulatory time after self-admin2.32.54.82.20.4
Bone: tissue strength0.60.61.21.10.0
Total heroin consumption3.94.65.5-1.92.3
Bone: trabecular number3.45.49.3-3.01.2
Bone: trabecular spacing1.31.71.81.31.3
Bone: trabecular thickness0.10.10.2-0.40.1
Bone: trabecular tissue density1.82.55.10.2-2.3
Water consumed over 24 hours0.20.20.4-0.10.6
Number of responses in last shaping day0.90.91.2-0.8-1.1