Hub : Genes

Erbb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Erbb2	0.1	0.09	1.5e-04	0.03	0.04	0.05	0.05	1.3e-03	2.0e-04	8.0e-05	9.9e-05
2	Adipose	gene expression	Erbb2	0.12	0.08	1.1e-04	0.01	0.02	0.03	0.02	4.1e-02	2.1e-03	1.5e-04	3.4e-03
3	Brain	alternative polyA	XM_039085177.2	0.11	0.09	4.0e-03	0	0.01	0.02	0.02	1.4e-01	1.5e-02	2.6e-03	7.8e-03
4	Brain	alternative polyA	XM_039085176.2	0.12	0.09	4.1e-03	0	0.01	0.02	0.02	1.4e-01	1.5e-02	3.4e-03	8.6e-03
5	Brain	alternative polyA	NM_017003.2	0.12	0.09	4.3e-03	0	0.01	0.03	0.02	1.4e-01	2.1e-02	1.7e-03	6.4e-03
6	Brain	alternative polyA	NM_017003.2	0.14	0.1	4.2e-03	0	0.01	0.02	0.02	1.4e-01	2.1e-02	2.4e-03	6.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.7	1.3	1.6	1.3	0.9	1.1	1.1	-1.2	-1.1
Area under the delay curve	0.2	0.2	0.3	0.5	0.2	0.5	0.5	-0.5	-0.5
BMI with tail	1.5	5.1	12.5	-3.5	-3.2	-1.6	-1.5	1.2	1.1
BMI without tail	1.1	3.3	9.7	-3.1	-2.2	-1.3	-1.3	1.0	0.9
Body weight	3.2	14.1	34.6	-5.9	-4.6	-3.0	-2.9	2.6	2.3
Weight adjusted by age	0.1	0.2	0.3	-0.1	0.2	0.5	0.5	-0.5	-0.6
Bone surface	0.2	0.4	0.7	0.0	0.2	0.7	0.7	-0.8	-0.8
Bone volume	0.7	1.3	2.2	0.4	0.5	1.3	1.3	-1.4	-1.5
Breakpoint value in progressive ratio session	0.2	0.3	0.8	-0.9	-0.0	-0.4	-0.5	0.4	0.4
Number of licking bursts	0.8	1.3	1.9	0.8	0.5	1.3	1.3	-1.3	-1.4
Context. condit. distance diff. score	0.8	1.0	1.6	-0.4	-0.4	-1.1	-1.1	1.3	1.3
Locomotion velocity, session 1	0.2	0.2	1.0	0.1	1.0	0.2	0.2	-0.2	-0.2
Locomotion distance, session 1	1.1	1.4	4.4	-2.1	-1.2	-0.9	-0.9	0.7	0.6
Locomotion velocity, session 2	0.4	0.5	0.6	-0.6	-0.1	-0.8	-0.8	0.8	0.7
Locomotion distance, session 2	0.5	0.7	2.6	-1.6	-1.1	-0.4	-0.4	0.1	0.1
Locomotion velocity, session 3	0.9	1.0	1.2	-0.9	-0.8	-1.1	-1.1	1.0	1.0
Locomotion distance, session 3	0.7	0.7	1.2	-1.1	-1.0	-0.8	-0.8	0.7	0.7
Stereotopy head waving bouts, day 3	0.6	0.7	1.7	1.3	0.6	0.8	0.8	-0.8	-0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.4	-0.1	0.4	0.4	-0.4	-0.4
Locomotion velocity, session 7	0.1	0.1	0.3	-0.6	-0.4	-0.1	-0.1	0.1	0.0
Locomotion distance, session 7	0.0	0.0	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	0.4	-0.2	0.5	0.5	-0.5	-0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.7	-0.3	-0.8	-0.2	-0.2	0.1	0.1
Locomotion velocity, session 8	2.7	3.2	4.0	-2.0	-1.2	-1.9	-1.9	1.9	1.8
Locomotion distance, session 8	1.0	1.4	2.8	-1.7	-1.4	-1.0	-1.0	0.9	0.9
Degree of sensitization distance	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	0.2	0.2
Degree of sensitization stereotypy	0.4	0.5	0.6	0.7	0.1	0.8	0.8	-0.8	-0.7
Conditioned locomotion	0.1	0.1	0.1	0.3	0.2	-0.2	-0.2	0.2	0.3
Cocaine response after cond. corrected	2.2	2.6	3.4	1.3	0.9	1.8	1.8	-1.8	-1.8
Cocaine response after cond. not corrected	4.0	4.7	5.7	2.0	1.5	2.4	2.4	-2.4	-2.3
Cocaine response before conditioning	0.5	0.6	1.3	1.2	0.9	0.7	0.6	-0.5	-0.5
Saline control response	0.3	0.4	0.5	0.4	0.1	0.7	0.7	-0.7	-0.7
Bone: connectivity density	0.7	1.1	1.7	1.3	1.0	0.9	1.0	-1.0	-0.9
Bone: cortical apparent density	2.8	3.8	9.1	3.0	2.9	1.3	1.3	-1.1	-0.9
Bone: cortical area	0.7	1.0	1.5	1.1	1.2	1.0	1.0	-0.9	-0.9
Bone: cortical porosity	2.0	2.2	2.6	1.4	1.2	1.6	1.6	-1.5	-1.5
Bone: cortical porosity	2.2	2.4	2.8	1.5	1.3	1.7	1.7	-1.6	-1.6
Bone: cortical thickness	1.0	1.7	3.6	1.9	1.8	1.0	1.0	-0.9	-0.8
Bone: cortical thickness	2.6	3.1	6.1	2.5	2.2	1.5	1.5	-1.4	-1.3
Bone: cortical tissue density	2.8	3.8	9.2	3.0	2.9	1.3	1.3	-1.1	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	1.1	0.7	1.1	-0.0	0.0	0.0	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.6	0.7	-0.4	-0.4	0.4	0.6
Condit. Reinf. active responses	0.6	0.8	2.5	1.3	1.6	0.4	0.4	-0.3	-0.3
Condit. Reinf. inactive responses	0.9	1.1	1.5	1.2	1.1	1.0	1.0	-0.9	-0.9
Incentive salience index mean	1.5	1.9	4.9	1.8	2.2	0.9	1.0	-0.9	-0.8
Condit. Reinf. lever presses	2.9	4.1	8.2	2.3	2.9	1.7	1.7	-1.6	-1.6
Condit. Reinf. active minus inactive responses	1.0	1.3	1.3	1.1	1.1	1.1	1.1	-1.1	-1.1
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.1	0.4	0.2	0.9	0.9	-1.0	-1.0
Condit. Reinf. active responses	1.8	2.5	2.8	1.4	1.4	1.6	1.6	-1.7	-1.7
Condit. Reinf. inactive responses	2.4	3.1	3.4	1.9	1.8	1.8	1.7	-1.7	-1.7
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.1
Condit. Reinf. lever reinforcers received	1.6	2.3	2.5	1.5	1.6	1.5	1.5	-1.5	-1.5
Conditioned reinforcement - actives	0.7	1.2	2.0	1.4	1.0	1.1	1.1	-0.9	-0.8
Conditioned reinforcement - inactives	0.0	0.1	0.1	0.3	0.3	0.2	0.2	-0.2	-0.1
Conditioned locomotion	1.1	1.4	1.8	1.3	0.8	1.2	1.3	-1.2	-1.2
Patch foraging indifference point 0 sec	0.3	0.6	2.0	1.1	1.4	0.4	0.3	-0.3	-0.1
Patch foraging indifference point AUC	0.0	0.1	0.1	0.3	-0.1	0.3	0.3	-0.2	-0.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.1	0.9	0.0	1.0	1.0	-1.0	-1.0
Delay disc. indifference point, 16s delay	0.2	0.3	0.8	0.9	0.7	-0.2	-0.2	0.3	0.4
Delay disc. indifference point, 2s delay	2.9	3.2	4.0	1.4	1.1	2.0	2.0	-2.0	-2.0
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	-0.1	-0.0	-0.4	-0.5	0.5	0.5
Delay disc. indifference point, 4s delay	1.1	1.2	1.5	0.9	0.7	1.2	1.2	-1.2	-1.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.2	-0.4	0.1	0.1	-0.1	-0.0
Indifference point function ln k	0.4	0.7	1.0	-0.6	-0.4	-0.9	-0.9	0.9	1.0
Indifference point function log k	0.4	0.7	1.0	-0.6	-0.4	-0.9	-0.9	0.9	1.0
Patch foraging total patch changes 0 sec	0.2	0.4	1.4	0.8	1.2	0.2	0.2	-0.1	0.0
Patch foraging total patch changes 12 sec	2.2	2.9	3.6	1.9	1.2	1.8	1.8	-1.8	-1.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.7	0.4	0.3	0.3	-0.2	-0.2
Patch foraging total patch changes 24 sec	0.3	0.4	1.5	1.2	0.7	0.5	0.4	-0.4	-0.3
Patch foraging total patch changes 6 sec	0.8	1.2	3.3	1.3	1.8	0.8	0.8	-0.7	-0.6
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	-0.1	-0.1
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.0	0.0	0.0
Patch foraging water rate 12 sec	0.1	0.2	0.3	-0.1	0.3	-0.4	-0.4	0.6	0.5
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.3	0.3	0.6	0.6	-0.7	-0.7
Patch foraging water rate 24 sec	0.3	0.5	1.0	0.6	1.0	0.6	0.6	-0.6	-0.6
Patch foraging water rate 6 sec	0.7	1.0	1.2	1.1	0.8	1.0	1.0	-1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.4	1.2	1.0	0.0	0.0	0.2	0.2
Distance traveled before self-admin	1.0	1.3	1.7	0.8	1.0	1.3	1.3	-1.2	-1.3
Distance traveled after self-admin	0.1	0.2	0.7	-0.9	-0.3	-0.3	-0.2	0.1	0.1
Extensor digitorum longus weight	3.4	13.3	15.7	-4.0	-2.4	-3.8	-3.8	3.9	3.7
Bone: elastic displacement	0.0	0.1	0.2	-0.2	-0.4	-0.1	-0.1	0.1	0.1
Bone: elastic work	0.3	0.4	0.7	0.1	0.2	0.7	0.7	-0.8	-0.8
Bone: endosteal estimation	0.6	1.3	3.7	-1.9	-1.7	-0.5	-0.5	0.4	0.3
Bone: endosteal perimeter	0.3	0.7	2.5	-1.6	-1.3	-0.3	-0.3	0.3	0.1
Epididymis fat weight	0.3	0.9	1.5	0.2	-0.1	1.1	1.1	-1.1	-1.2
Delta time in closed arm before/after self-admin	3.7	3.5	4.9	-2.2	-1.5	-2.0	-2.0	1.8	1.7
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.4	0.5	0.3	0.4	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.6	-0.1	-0.4	-0.4	0.3	0.3
Delay discount exponential model param	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.4	0.3	0.3
Extinction: sum of active levers before priming	0.8	0.9	1.9	-1.2	-1.4	-0.8	-0.7	0.7	0.7
Active lever presses in extinction session 6	2.2	2.1	3.7	-0.2	-0.1	1.7	1.6	-1.9	-1.9
Bone: final force	1.7	2.7	3.3	1.4	1.1	1.8	1.8	-1.8	-1.8
Bone: final moment	1.5	2.4	3.0	1.3	1.0	1.7	1.7	-1.7	-1.7
Food consumed during 24 hour testing period	0.3	0.4	1.2	-1.0	-1.1	-0.4	-0.4	0.3	0.3
Glucose	2.4	3.8	4.9	1.3	-1.5	2.2	2.2	-2.1	-2.1
Heart weight	0.5	0.7	2.7	-1.6	-0.9	-0.6	-0.6	0.5	0.4
Delay discount hyperbolic model param	0.2	0.2	0.3	-0.4	-0.3	-0.5	-0.5	0.5	0.5
Intermittent access intake day 1-15 change	0.3	0.7	1.2	-1.0	-1.1	-0.8	-0.8	0.6	0.6
Intermittent access intake escalation	0.3	0.5	1.1	-1.0	-1.0	-0.6	-0.6	0.5	0.5
Intermittent access intake escalation 2	1.0	1.2	2.2	-1.4	-1.5	-0.9	-0.9	0.8	0.7
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.2	0.4	0.1	0.0	-0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.3	-0.0	-0.3	-0.3	0.3	0.4
Intermitt. access escalation Index	1.9	2.6	3.9	-1.7	-2.0	-1.7	-1.5	1.5	1.4
Intermittent access day 1 total infusions	0.5	0.8	1.9	0.9	1.4	0.9	0.8	-0.7	-0.7
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.1	0.1	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.0
Intermittent access total infusions	0.1	0.2	0.6	0.3	0.8	0.3	0.3	-0.2	-0.2
Intermittent access day 1 locomotion	0.9	1.1	2.4	1.1	1.5	1.0	0.9	-0.8	-0.8
Intermittent access day 15 total locomotion	0.8	1.5	1.7	0.9	1.1	1.3	1.3	-1.3	-1.3
Intermittent access total locomotion	1.1	1.3	1.7	1.2	1.3	1.1	1.1	-1.0	-1.0
Intermittent access standard deviation	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0	-0.1	-0.0
Left kidney weight	0.8	3.6	4.7	-2.2	-2.1	-1.8	-1.8	1.7	1.6
Right kidney weight	0.1	0.5	1.8	-1.1	-1.3	-0.4	-0.4	0.2	0.1
Cocaine induced anxiety	3.9	5.6	9.2	-3.0	-2.9	-2.1	-2.1	1.9	1.8
Post-drug Anxiety	2.5	2.7	3.5	-1.9	-1.7	-1.6	-1.6	1.5	1.5
Baseline Anxiety	3.7	4.2	6.2	2.5	2.4	2.0	2.0	-1.7	-1.6
Tail length	0.5	2.1	3.3	-1.8	-0.6	-1.4	-1.5	1.5	1.5
Length with tail	1.5	6.7	13.7	-3.7	-2.3	-2.4	-2.4	2.3	2.1
Length without tail	0.9	3.0	6.8	-2.6	-2.0	-1.5	-1.4	1.3	1.2
Times rat made contact with spout	0.8	0.9	1.3	0.6	0.3	1.1	1.1	-1.1	-1.1
Lifetime Intake	0.3	0.3	1.1	0.5	1.1	0.4	0.4	-0.3	-0.3
Liver weight, left	0.0	0.1	0.1	-0.1	0.2	0.2	0.3	-0.3	-0.3
Liver weight, right	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.1	0.0	0.1
Locomotor activity	1.3	2.0	2.6	1.0	0.8	1.6	1.6	-1.6	-1.6
Locomotor testing distance	1.1	2.0	2.9	1.7	1.2	1.4	1.5	-1.4	-1.3
Locomotor testing rearing	1.2	2.4	4.7	2.2	1.8	1.3	1.3	-1.3	-1.1
Locomotion in novel chamber	8.2	10.5	12.5	3.3	3.5	3.2	3.2	-3.1	-3.0
Locomotion in novel chamber post-restriction	0.8	1.3	2.4	-0.2	-0.4	1.2	1.3	-1.5	-1.5
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.2	0.2	0.2	0.2	-0.2	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	0.4	-0.2	0.5	0.5	-0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.0	1.0	0.8	-0.0	-0.1	0.2	0.3
Bouts of movement, locomotor time 1	1.2	1.4	1.8	-1.3	-0.8	-1.3	-1.2	1.2	1.1
Total resting periods, locomotor time 1	0.8	0.9	1.4	-1.2	-0.5	-1.1	-1.0	1.0	0.9
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.6	-0.1	-0.3	-0.3	0.2	0.1
Distance moved, locomotor task time 1	0.5	0.8	1.3	1.1	0.7	0.9	0.9	-0.7	-0.7
Vertical activity count, locomotor time 1	0.3	0.7	0.8	0.8	0.9	0.9	0.9	-0.7	-0.8
Time >=10cm from walls, locomotor time 2	2.5	3.6	6.0	2.4	1.9	2.0	1.9	-1.6	-1.5
Bouts of movement, locomotor time 2	0.4	0.7	1.0	0.4	0.8	-0.8	-0.8	0.9	1.0
Total resting periods, locomotor time 2	0.6	1.1	1.8	0.1	0.6	-1.2	-1.2	1.3	1.3
Rest time, locomotor task time 2	0.8	1.0	1.7	-1.3	-0.5	-1.1	-1.0	1.0	0.9
Distance moved, locomotor task time 2	0.5	0.6	1.0	0.5	0.1	1.0	1.0	-0.9	-0.9
Vertical activity count, locomotor time 2	0.0	0.1	0.1	0.0	0.1	0.3	0.3	-0.3	-0.3
Light reinforcement 1	0.3	0.8	1.0	0.8	0.5	0.9	0.9	-1.0	-1.0
Light reinforcement 2	1.2	1.8	2.9	0.6	0.5	1.4	1.5	-1.7	-1.7
Bone: marrow area	0.6	1.2	3.6	-1.9	-1.7	-0.5	-0.6	0.4	0.3
Bone: maximum diameter	0.3	0.5	0.6	0.7	0.8	0.7	0.7	-0.7	-0.7
Bone: maximum force	0.2	0.3	0.5	0.3	0.2	0.7	0.7	-0.7	-0.7
Bone: maximum moment	0.1	0.2	0.4	0.1	0.0	0.5	0.5	-0.6	-0.6
Mean time between licks in bursts	0.2	0.6	1.6	-1.3	-0.8	-0.6	-0.6	0.5	0.4
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.4	0.4	0.4
Cd content in liver	1.1	1.3	2.2	-1.5	-1.4	-1.0	-1.0	0.9	0.8
Co content in liver	2.5	2.9	3.6	-1.4	-1.1	-1.9	-1.9	1.9	1.9
Cu content in liver	0.3	0.4	0.6	-0.3	0.2	-0.7	-0.7	0.7	0.8
Fe content in liver	0.2	0.3	1.1	-1.0	-0.6	-0.1	-0.1	0.1	0.0
K content in liver	0.1	0.1	0.3	0.5	0.5	0.1	0.1	-0.0	0.0
Mg content in liver	0.5	0.5	1.0	0.3	0.2	-0.7	-0.7	0.9	1.0
Mn content in liver	0.2	0.2	0.8	0.7	0.9	-0.0	-0.1	0.2	0.3
Na content in liver	1.5	1.6	2.4	0.6	0.5	1.4	1.4	-1.5	-1.5
Rb content in liver	0.7	0.8	1.2	1.1	1.0	0.9	0.9	-0.8	-0.7
Se content in liver	2.3	2.7	4.7	2.2	2.1	1.4	1.4	-1.3	-1.2
Sr content in liver	1.4	1.2	1.8	-0.6	-0.2	-1.2	-1.2	1.3	1.3
Zn content in liver	0.8	0.9	1.6	1.3	1.2	0.7	0.8	-0.7	-0.7
Bone: minimum diameter	0.1	0.2	0.3	-0.3	-0.1	0.5	0.5	-0.4	-0.5
Time in familiar zone, hab. session 1	4.1	4.0	5.3	1.3	1.6	2.1	2.2	-2.2	-2.3
Time in novel zone, hab. session 1	1.1	1.1	1.7	-0.2	-0.8	-1.1	-1.2	1.2	1.3
Total zone transitions, hab. session 1	0.6	0.8	1.0	-1.0	-0.3	-1.0	-1.0	1.0	0.9
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.2	0.2
Locomotion velocity, hab. session 1	0.4	0.6	0.9	-0.9	-0.8	-0.8	-0.8	0.7	0.7
Time in familiar zone, hab. session 2	0.8	0.9	1.3	0.6	0.5	1.1	1.1	-1.1	-1.1
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.0	0.0	-0.5	-0.6	0.6	0.6
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.5	0.0	-0.2	-0.2	0.2	0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.6	-0.8	-0.8	-0.0	0.0	-0.1	-0.2
Locomotion velocity, hab. session 2	0.1	0.2	0.6	-0.8	-0.7	-0.1	-0.1	-0.0	-0.1
Novel to familiar place preference ratio	2.5	2.8	3.5	-1.2	-1.2	-1.8	-1.8	1.9	1.9
Novelty place preference	2.5	2.7	3.7	-1.0	-1.1	-1.8	-1.8	1.9	1.9
Time in novel zone, NPP test	1.6	1.7	2.5	-0.7	-0.9	-1.4	-1.4	1.6	1.6
Total zone transitions, NPP test	0.5	0.7	0.9	0.2	0.9	0.9	0.9	-0.9	-0.9
Total locomotion distance, NPP test	0.3	0.5	0.8	-0.1	-0.1	0.7	0.8	-0.9	-0.9
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.6	-0.4	0.2	0.2	-0.3	-0.4
Intraocular pressure	1.0	1.5	2.2	-1.5	-1.1	-1.2	-1.2	1.2	1.1
Delta distance traveled before/after self-admin	2.2	2.3	2.6	-1.6	-1.3	-1.6	-1.6	1.5	1.5
Delta ambulatory time before/after self-admin	2.3	2.9	4.4	-2.1	-1.9	-1.6	-1.6	1.4	1.4
Parametrial fat weight	0.4	0.9	1.4	0.4	0.5	1.0	1.0	-1.2	-1.2
Pavlov. Cond. lever latency	3.2	4.1	5.0	-1.7	-1.6	-2.1	-2.2	2.2	2.2
Pavlov. Cond. magazine entry latency	9.1	11.7	12.8	3.6	3.2	3.4	3.5	-3.5	-3.4
Pavlov. Cond. change in total contacts	4.6	4.9	8.8	3.0	2.5	2.0	2.0	-1.9	-1.7
Pavlov. Cond. index score	8.6	10.8	11.8	3.2	2.9	3.4	3.4	-3.4	-3.4
Pavlov. Cond. latency score	7.0	8.8	10.0	2.8	2.5	3.1	3.1	-3.2	-3.1
Pavlov. Cond. lever contacts	4.5	5.4	6.1	2.1	2.0	2.4	2.4	-2.5	-2.4
Pavlov. Cond. magazine entry number	9.3	11.8	14.6	-3.8	-3.1	-3.4	-3.5	3.4	3.3
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.5	-1.2	-1.0	-1.5	-1.6	1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	9.7	12.0	12.7	3.5	3.1	3.5	3.6	-3.6	-3.5
Pavlov. Cond. response bias	8.9	11.0	12.9	3.6	3.2	3.3	3.3	-3.3	-3.2
Pavlov. Cond. lever latency	0.4	0.6	0.8	-0.6	-0.4	-0.8	-0.8	0.9	0.9
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.6	0.9	0.7	0.7	-0.6	-0.6
Pavlov. Cond. change in total contacts	0.7	1.1	2.1	1.4	1.5	0.9	0.9	-0.8	-0.8
Pavlov. Cond. index score	0.5	0.7	0.8	0.7	0.7	0.9	0.9	-0.9	-0.9
Pavlov. Cond. latency score	0.5	0.7	0.8	0.7	0.7	0.9	0.9	-0.8	-0.9
Pavlov. Cond. lever contacts	0.7	1.0	1.4	0.7	0.5	1.1	1.1	-1.2	-1.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.7	-1.1	-1.3	-0.9	-1.0	0.9	0.9
Pavlov. Cond. intertrial magazine entries	3.1	4.7	5.7	-1.7	-1.7	-2.3	-2.3	2.4	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.7	0.6	0.6	0.8	0.8	-0.8	-0.8
Pavlov. Cond. response bias	1.6	2.2	2.5	1.3	1.2	1.6	1.6	-1.6	-1.6
Time in closed arm before self-admin	0.2	0.3	0.9	0.9	0.5	0.3	0.4	-0.3	-0.2
Time in closed arm after self-admin	1.5	1.6	2.5	-0.7	-0.4	-1.4	-1.5	1.5	1.6
Time in open arm before self-admin	0.1	0.2	0.5	-0.7	0.1	-0.3	-0.3	0.4	0.3
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	0.3	0.2	0.2	-0.1	-0.2
Bone: periosteal estimation	0.1	0.2	0.3	-0.3	-0.2	0.5	0.5	-0.5	-0.6
Bone: periosteal perimeter	0.2	0.4	0.8	-0.3	0.1	0.7	0.7	-0.8	-0.9
Bone: post-yield work	0.4	0.6	0.8	-0.9	-0.5	-0.9	-0.8	0.8	0.8
Progressive ratio test 1 active lever presses	0.4	0.5	0.6	0.8	0.8	0.7	0.7	-0.6	-0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	0.6	0.6	0.6	0.5	-0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.1	0.6	-0.2	-0.2	0.3	0.3
Progressive ratio test 2 active lever presses	2.2	2.6	4.2	1.9	2.1	1.5	1.5	-1.3	-1.3
Progressive ratio test 2 breakpoint	2.6	3.0	4.5	1.9	2.1	1.7	1.6	-1.4	-1.4
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.9	0.5	0.9	0.7	0.6	-0.5	-0.5
Incentive Sensitization - Responses	2.8	4.0	5.2	2.2	2.3	2.0	1.9	-1.8	-1.8
Incentive Sensitization - Breakpoint	2.9	3.8	5.0	2.1	2.2	1.9	1.9	-1.8	-1.8
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.8	0.3	0.6	0.9	0.8	-0.8	-0.8
Progressive ratio	0.5	0.9	2.9	1.0	1.7	0.6	0.6	-0.5	-0.6
Food seeking constrained by brief footshock	0.3	0.3	0.5	0.1	-0.5	0.6	0.7	-0.7	-0.7
Seeking ratio, punishment vs. effort	0.5	0.7	3.2	-0.7	-1.8	-0.4	-0.4	0.4	0.4
Retroperitoneal fat weight	0.0	0.1	0.2	0.1	-0.4	0.2	0.1	-0.2	-0.2
Reaction time number correct	0.2	0.3	0.5	0.1	0.5	0.6	0.6	-0.6	-0.7
Reaction time mean minus median	0.4	1.1	1.4	-0.8	-1.2	-1.1	-1.1	1.0	1.0
Reaction time mean minus median AUC	0.0	0.1	0.2	0.2	-0.5	-0.3	-0.2	0.3	0.3
Reaction time num false alarms	2.3	3.3	4.9	1.5	2.2	1.8	1.8	-1.8	-1.8
Reaction time num false alarms AUC	1.5	2.3	3.3	1.2	1.8	1.5	1.5	-1.5	-1.5
Reaction time trials correct on left	0.2	0.3	0.5	0.1	0.5	0.6	0.6	-0.6	-0.7
Reaction time trials on left	0.2	0.3	0.4	0.1	0.5	0.6	0.6	-0.6	-0.7
Reaction time mean	0.5	0.8	1.2	-0.3	-0.5	-1.0	-1.0	1.0	1.1
Reaction time mean AUC	0.5	0.8	1.2	-0.4	-0.6	-1.1	-1.0	1.0	1.1
Median of all reaction times	0.2	0.3	0.4	0.2	-0.0	-0.6	-0.6	0.6	0.7
Reaction time omissions	0.0	0.0	0.1	0.2	0.0	-0.3	-0.2	0.1	0.1
Reaction time false alarm rate	1.0	1.4	2.3	1.2	1.5	1.1	1.1	-1.1	-1.1
Reaction time premature initiation rate	0.1	0.1	0.4	-0.2	-0.7	0.2	0.2	-0.3	-0.3
Reaction time premature initiations	0.1	0.2	0.5	-0.6	-0.7	0.2	0.2	-0.3	-0.4
Std. dev. reaction times	0.3	0.5	0.6	-0.4	-0.8	-0.8	-0.7	0.7	0.7
Reaction time trials completed	0.2	0.3	0.4	0.1	0.5	0.6	0.6	-0.6	-0.7
Reaction time trials AUC	0.1	0.3	0.5	0.2	0.7	0.6	0.5	-0.5	-0.6
Run reversals in cocaine runway, females	1.5	1.5	1.8	-1.0	-1.0	-1.2	-1.3	1.4	1.4
Run reversals in cocaine runway, males	0.5	0.5	0.7	0.6	0.0	0.8	0.8	-0.8	-0.8
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.1	0.7	-0.3	-0.3	0.4	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.4	0.0	-0.0	0.1	0.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.0	0.6	-0.4	-0.4	0.4	0.4
Std. dev. time between licks in bursts	0.2	0.3	0.7	-0.8	-0.8	-0.3	-0.2	0.1	0.1
Total sessions with >9 infusions	0.3	0.3	1.4	0.7	1.2	-0.2	-0.1	0.3	0.3
Short access day 1 total inactive lever presses	0.8	1.1	2.0	1.2	1.4	0.9	0.9	-0.9	-0.8
Short access day 10 total inactive lever presses	0.6	1.4	1.9	-1.3	-0.8	-1.4	-1.4	1.1	1.1
Short access day 1 total infusions	0.3	0.4	1.6	0.9	1.3	0.1	0.1	0.0	0.1
Short access day 10 total infusions	0.7	0.9	1.2	0.9	1.1	0.9	1.0	-0.9	-0.9
Short access total infusions	0.5	0.6	1.8	0.8	1.4	0.6	0.6	-0.5	-0.5
Short access day 1 locomotion	0.4	0.5	1.6	1.0	1.3	0.4	0.4	-0.4	-0.3
Short access day 10 total locomotion	1.0	1.8	2.1	1.5	1.0	1.4	1.4	-1.4	-1.3
Short access total locomotion	0.4	0.5	1.0	0.8	1.0	0.6	0.6	-0.6	-0.5
One hour access (0.3 mA shock)	0.2	0.2	0.6	0.6	0.8	0.0	0.0	0.2	0.2
Compulsive drug intake	1.8	2.1	3.8	0.0	-0.4	-1.6	-1.6	1.8	2.0
One hour access (shock baseline)	0.1	0.2	0.3	0.2	0.5	0.5	0.5	-0.5	-0.5
Social response proportion	0.0	0.0	0.2	0.1	0.4	-0.0	-0.0	0.1	0.1
Social responses	0.5	0.7	1.1	0.2	0.6	0.9	1.0	-1.0	-1.0
Social time	0.6	0.9	1.4	-0.2	-1.2	0.9	0.9	-1.0	-1.1
Soleus weight	0.5	1.3	2.1	0.7	0.4	1.3	1.3	-1.4	-1.4
Bone: stiffness	0.3	0.5	0.7	0.5	0.5	0.8	0.8	-0.8	-0.8
Tibialis anterior weight	0.4	1.4	3.1	-1.8	-1.2	-1.1	-1.1	1.0	0.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	-0.2	-0.4	0.5	0.5	-0.6	-0.7
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.2	0.6	0.3	0.3	-0.3	-0.4
Time to tail flick, test, before self-admin	2.0	2.0	4.4	-1.7	-2.1	-1.2	-1.2	1.1	1.1
Time to tail flick, test, after self-admin	0.9	0.9	1.6	-0.2	-0.2	1.1	1.0	-1.2	-1.3
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.6	0.7	0.7	1.2	1.2	-1.2	-1.3
Delta time to tail flick, test, before/after SA	5.0	5.1	5.9	2.1	2.2	2.4	2.3	-2.3	-2.3
Tibia length	0.2	0.6	1.9	-1.3	-1.4	0.0	-0.0	-0.1	-0.3
Ambulatory time before self-admin	0.2	0.3	0.4	0.3	0.5	0.6	0.6	-0.6	-0.6
Ambulatory time after self-admin	1.1	1.3	4.0	-2.0	-1.4	-0.9	-0.8	0.6	0.5
Bone: tissue strength	0.8	0.8	0.9	-0.8	-0.8	-0.9	-0.9	0.9	0.9
Total heroin consumption	4.2	4.9	7.2	1.0	1.2	2.5	2.5	-2.7	-2.7
Bone: trabecular number	3.0	4.9	5.5	2.3	1.8	2.3	2.3	-2.3	-2.2
Bone: trabecular spacing	0.1	0.2	0.6	-0.8	-0.5	0.2	0.2	-0.3	-0.4
Bone: trabecular thickness	0.0	0.0	0.0	0.2	0.2	0.0	0.1	-0.1	-0.1
Bone: trabecular tissue density	1.4	2.1	3.5	-0.3	-0.5	-1.6	-1.6	1.8	1.9
Water consumed over 24 hours	0.1	0.2	0.7	-0.5	-0.9	0.1	0.1	-0.2	-0.3
Number of responses in last shaping day	0.8	0.9	1.4	-0.5	-0.4	-1.0	-1.1	1.1	1.2