Hub : Genes

Eml2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA XM_039093638.2 0.03 0.03 8.3e-04 0.02 0.02 0.02 0.02 1.3e-03 2.3e-03 1.4e-03 2.9e-03
2 Adipose isoform ratio XM_039093638.2 0.07 0.06 5.6e-06 0.05 0.05 0.05 0.05 2.7e-06 4.0e-06 6.6e-06 5.5e-06
3 Liver mRNA stability Eml2 0.35 0.18 5.7e-15 0.12 0.12 0.13 0.12 1.1e-12 1.1e-13 5.3e-14 5.2e-13
4 Liver alternative polyA XM_039093638.2 0.4 0.17 0.0e+00 0.32 0.32 0.32 0.32 1.4e-35 1.7e-36 7.4e-37 1.8e-36
5 Liver alternative polyA NM_138921.3 0.41 0.16 0.0e+00 0.3 0.31 0.31 0.31 3.0e-34 3.8e-35 2.1e-35 6.1e-35
6 Adipose alternative polyA NM_138921.3 0.03 0.03 8.4e-04 0.02 0.02 0.02 0.02 1.4e-03 2.5e-03 1.7e-03 3.4e-03
7 Liver gene expression Eml2 0.04 0.05 2.7e-03 0.02 0.01 0 0.01 6.0e-03 1.7e-02 1.5e-01 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.00.00.00.20.2-0.1-0.10.1-0.10.2
Area under the delay curve1.51.72.2-1.3-1.31.2-1.41.41.21.5
BMI with tail0.82.63.51.91.9-1.61.5-1.4-1.6-1.4
BMI without tail1.03.14.12.02.0-1.81.5-1.5-1.9-1.4
Body weight1.56.68.02.82.8-2.72.3-2.3-2.8-2.2
Weight adjusted by age0.00.10.10.40.4-0.20.1-0.1-0.40.0
Bone surface0.20.40.60.80.8-0.60.6-0.6-0.7-0.6
Bone volume0.20.30.50.70.7-0.60.5-0.4-0.6-0.4
Breakpoint value in progressive ratio session2.32.73.5-1.9-1.91.5-1.71.71.21.6
Number of licking bursts2.74.34.72.02.0-2.12.2-2.2-2.1-2.1
Context. condit. distance diff. score0.10.10.10.10.1-0.20.3-0.3-0.2-0.3
Locomotion velocity, session 10.10.10.1-0.2-0.20.2-0.30.30.20.3
Locomotion distance, session 10.00.00.00.00.00.00.1-0.10.1-0.1
Locomotion velocity, session 21.41.71.71.31.3-1.31.3-1.3-1.3-1.3
Locomotion distance, session 20.20.30.30.60.6-0.50.6-0.6-0.5-0.6
Locomotion velocity, session 30.20.30.30.50.5-0.50.5-0.5-0.5-0.5
Locomotion distance, session 30.91.01.1-1.0-1.01.0-0.90.91.00.9
Stereotopy head waving bouts, day 31.11.31.31.11.1-1.21.2-1.1-1.1-1.1
Stereotopy head waving duration, day 31.01.21.41.01.0-1.11.2-1.2-1.0-1.2
Locomotion velocity, session 70.20.30.4-0.6-0.60.5-0.50.50.50.4
Locomotion distance, session 70.00.00.00.00.0-0.10.1-0.2-0.1-0.2
Stereotopy head waving bouts, day 71.01.21.31.11.1-1.11.1-1.1-1.1-1.0
Stereotopy head waving duration, day 70.91.01.21.11.1-1.11.0-1.0-1.0-0.9
Locomotion velocity, session 80.00.00.0-0.2-0.20.2-0.00.00.20.0
Locomotion distance, session 80.00.00.0-0.1-0.10.1-0.00.00.00.0
Degree of sensitization distance0.60.60.70.70.7-0.80.8-0.8-0.8-0.8
Degree of sensitization stereotypy1.21.31.51.21.2-1.21.1-1.1-1.1-1.0
Conditioned locomotion0.00.00.0-0.2-0.20.2-0.20.20.20.2
Cocaine response after cond. corrected0.50.60.70.60.6-0.80.8-0.8-0.8-0.8
Cocaine response after cond. not corrected1.31.51.61.11.1-1.31.3-1.3-1.3-1.3
Cocaine response before conditioning1.82.22.41.51.5-1.51.5-1.4-1.5-1.3
Saline control response2.02.73.01.71.7-1.61.7-1.7-1.5-1.6
Bone: connectivity density0.00.00.10.00.00.1-0.30.30.00.3
Bone: cortical apparent density0.00.10.2-0.0-0.00.1-0.40.40.20.3
Bone: cortical area1.52.32.71.41.4-1.51.6-1.6-1.5-1.6
Bone: cortical porosity0.20.20.4-0.7-0.70.5-0.30.30.50.3
Bone: cortical porosity0.00.00.1-0.2-0.20.10.0-0.00.1-0.1
Bone: cortical thickness0.50.91.10.90.9-0.91.0-1.0-0.9-1.0
Bone: cortical thickness1.31.61.81.21.2-1.21.3-1.3-1.2-1.2
Bone: cortical tissue density0.10.10.3-0.1-0.10.2-0.50.50.30.5
Condit. Reinf. active minus inactive responses0.50.60.70.90.9-0.80.6-0.6-0.9-0.6
Condit. Reinf. active-inactive response ratio0.40.40.60.80.8-0.70.4-0.4-0.8-0.4
Condit. Reinf. active responses0.30.30.50.70.7-0.70.4-0.4-0.7-0.4
Condit. Reinf. inactive responses0.10.10.1-0.4-0.40.4-0.30.30.40.2
Incentive salience index mean0.40.50.70.80.8-0.80.5-0.5-0.8-0.4
Condit. Reinf. lever presses0.10.10.20.50.5-0.40.1-0.1-0.4-0.1
Condit. Reinf. active minus inactive responses0.10.10.10.20.2-0.20.3-0.3-0.3-0.3
Condit. Reinf. active-inactive response ratio0.20.30.40.40.4-0.50.6-0.6-0.5-0.6
Condit. Reinf. active responses0.10.10.1-0.3-0.30.3-0.20.20.30.3
Condit. Reinf. inactive responses0.60.80.9-0.8-0.80.9-0.90.90.90.9
Condit. Reinf. lever presses0.10.20.20.30.3-0.30.5-0.5-0.3-0.5
Condit. Reinf. lever reinforcers received0.10.10.2-0.4-0.40.4-0.30.30.40.4
Conditioned reinforcement - actives1.42.53.41.81.8-1.51.5-1.5-1.2-1.4
Conditioned reinforcement - inactives0.71.01.61.31.3-1.00.8-0.8-1.0-0.8
Conditioned locomotion2.43.13.61.91.9-1.71.8-1.8-1.5-1.7
Patch foraging indifference point 0 sec0.30.50.80.30.3-0.60.9-0.9-0.7-0.9
Patch foraging indifference point AUC4.05.87.12.72.7-2.52.2-2.2-2.4-2.1
Delay disc. indifference point, 0s delay1.01.11.5-0.9-0.90.9-1.21.20.91.2
Delay disc. indifference point, 16s delay1.11.21.5-1.0-1.01.1-1.21.21.01.2
Delay disc. indifference point, 2s delay2.83.14.1-1.5-1.51.7-1.91.91.72.0
Delay disc. indifference point, 24s delay0.00.00.0-0.2-0.20.00.2-0.20.1-0.0
Delay disc. indifference point, 4s delay0.00.00.10.10.1-0.20.0-0.0-0.30.1
Delay disc. indifference point, 8s delay1.41.71.9-1.3-1.31.2-1.41.41.21.3
Indifference point function ln k1.73.04.7-2.2-2.21.8-1.41.31.81.3
Indifference point function log k1.73.04.7-2.2-2.21.8-1.41.31.81.3
Patch foraging total patch changes 0 sec0.40.71.10.50.5-0.71.1-1.1-0.8-1.0
Patch foraging total patch changes 12 sec2.02.63.11.71.7-1.71.5-1.4-1.6-1.4
Patch foraging total patch changes 18 sec2.23.33.81.81.8-1.91.8-1.7-2.0-1.7
Patch foraging total patch changes 24 sec0.61.01.81.41.4-1.10.7-0.7-1.0-0.6
Patch foraging total patch changes 6 sec2.23.44.01.71.7-1.82.0-2.0-1.8-2.0
Patch foraging time to switch 0 sec2.14.45.4-1.9-1.92.0-2.32.32.02.2
Patch foraging water rate 0 sec2.55.26.32.12.1-2.22.5-2.5-2.2-2.4
Patch foraging water rate 12 sec0.10.10.20.20.2-0.30.4-0.5-0.3-0.4
Patch foraging water rate 18 sec0.00.10.10.20.2-0.10.4-0.4-0.0-0.3
Patch foraging water rate 24 sec0.40.50.80.50.5-0.70.9-0.9-0.7-0.7
Patch foraging water rate 6 sec0.60.80.91.01.0-0.80.9-0.9-0.8-0.8
Seeking ratio, delayed vs. immediate footshock1.92.42.6-1.6-1.61.5-1.61.61.41.5
Distance traveled before self-admin0.00.10.10.30.3-0.10.3-0.30.1-0.3
Distance traveled after self-admin0.30.30.8-0.5-0.50.7-0.40.40.90.4
Extensor digitorum longus weight1.97.68.42.82.8-2.92.7-2.6-2.9-2.5
Bone: elastic displacement0.81.01.5-0.9-0.90.8-1.21.20.71.1
Bone: elastic work0.00.10.10.20.2-0.30.1-0.1-0.4-0.2
Bone: endosteal estimation0.00.10.1-0.2-0.20.2-0.30.30.20.2
Bone: endosteal perimeter0.00.00.0-0.1-0.10.10.0-0.00.1-0.1
Epididymis fat weight0.20.60.8-0.6-0.60.6-0.90.90.70.9
Delta time in closed arm before/after self-admin0.40.40.7-0.8-0.80.6-0.40.30.60.4
Delta time in open arm before/after self-admin0.10.10.30.60.6-0.2-0.10.1-0.30.1
Diff in mean of infusions in LGA sessions1.01.31.7-1.0-1.01.0-1.31.30.91.2
Delay discount exponential model param1.11.31.61.11.1-1.11.2-1.2-1.0-1.3
Extinction: sum of active levers before priming0.00.00.1-0.3-0.30.0-0.20.2-0.10.1
Active lever presses in extinction session 60.10.10.20.20.2-0.40.3-0.3-0.4-0.3
Bone: final force0.40.70.80.80.8-0.90.8-0.8-0.9-0.7
Bone: final moment0.60.91.10.90.9-1.01.0-1.0-1.0-0.9
Food consumed during 24 hour testing period5.37.27.6-2.6-2.62.7-2.82.72.72.7
Glucose0.20.40.5-0.7-0.70.7-0.50.50.70.5
Heart weight2.13.23.91.71.7-1.72.0-2.0-1.6-2.0
Delay discount hyperbolic model param1.01.11.41.01.0-1.01.1-1.1-0.9-1.2
Intermittent access intake day 1-15 change0.10.20.20.40.4-0.40.4-0.4-0.4-0.4
Intermittent access intake escalation0.10.30.30.60.6-0.50.5-0.5-0.5-0.5
Intermittent access intake escalation 20.00.00.1-0.3-0.30.10.1-0.10.0-0.1
Intermitt. access day 1 inactive lever presses0.00.00.10.20.2-0.30.1-0.1-0.3-0.1
Intermitt. access day 15 inactive lever presses0.10.20.40.50.5-0.50.1-0.0-0.7-0.0
Intermitt. access escalation Index0.20.30.3-0.5-0.50.4-0.60.60.50.6
Intermittent access day 1 total infusions1.93.14.32.12.1-1.81.6-1.6-1.6-1.5
Intermittent access day 15 total infusions1.21.82.81.71.7-1.41.1-1.1-1.3-1.1
Intermittent access terminal intake (last 3 days)1.41.92.31.51.5-1.41.3-1.3-1.4-1.2
Intermittent access total infusions3.23.74.42.12.1-2.01.8-1.8-1.9-1.7
Intermittent access day 1 locomotion0.60.81.31.21.2-0.80.6-0.6-0.8-0.6
Intermittent access day 15 total locomotion0.20.40.80.90.9-0.60.5-0.5-0.5-0.5
Intermittent access total locomotion2.12.53.31.81.8-1.51.5-1.5-1.5-1.4
Intermittent access standard deviation0.10.10.2-0.4-0.40.4-0.40.40.20.4
Left kidney weight5.726.627.75.15.1-5.25.2-5.2-5.3-5.0
Right kidney weight5.324.025.44.84.8-5.05.0-4.9-5.0-4.8
Cocaine induced anxiety0.10.10.30.20.20.1-0.50.50.10.5
Post-drug Anxiety0.00.00.10.00.00.0-0.20.20.20.1
Baseline Anxiety0.20.20.6-0.8-0.80.4-0.0-0.00.6-0.1
Tail length0.51.92.61.41.4-1.51.3-1.2-1.6-1.1
Length with tail0.41.92.61.51.5-1.51.2-1.2-1.6-1.1
Length without tail0.41.41.81.31.3-1.31.0-1.0-1.4-0.9
Times rat made contact with spout0.10.10.2-0.4-0.40.3-0.20.20.30.2
Lifetime Intake3.23.94.92.22.2-2.11.8-1.8-2.0-1.7
Liver weight, left2.43.94.22.02.0-2.02.0-1.9-1.9-1.9
Liver weight, right1.72.93.81.91.9-1.81.5-1.5-1.8-1.4
Locomotor activity2.13.34.11.61.6-1.72.0-2.0-1.6-2.0
Locomotor testing distance1.22.22.51.51.5-1.41.6-1.6-1.3-1.6
Locomotor testing rearing4.79.59.93.13.1-3.13.1-3.1-2.9-3.0
Locomotion in novel chamber0.60.71.5-1.2-1.20.9-0.40.40.80.5
Locomotion in novel chamber post-restriction1.11.82.4-1.5-1.51.4-1.31.21.41.0
Fecal boli incidents, locomotor time 10.00.00.10.10.1-0.20.3-0.3-0.2-0.3
Change in fecal boli incidents, locomotor task0.60.60.8-0.8-0.80.7-0.90.90.70.9
Time >=10cm from walls, locomotor time 10.00.00.00.00.00.1-0.10.10.10.1
Bouts of movement, locomotor time 12.32.62.9-1.6-1.61.6-1.71.71.51.7
Total resting periods, locomotor time 12.93.23.7-1.7-1.71.7-1.91.91.71.9
Rest time, locomotor task time 10.10.20.2-0.4-0.40.4-0.50.50.30.4
Distance moved, locomotor task time 10.40.60.60.80.8-0.80.8-0.8-0.8-0.7
Vertical activity count, locomotor time 10.00.00.10.30.3-0.20.0-0.0-0.1-0.0
Time >=10cm from walls, locomotor time 20.00.10.1-0.2-0.20.3-0.20.20.40.2
Bouts of movement, locomotor time 24.87.78.1-2.7-2.72.8-2.82.82.62.8
Total resting periods, locomotor time 23.96.87.2-2.6-2.62.7-2.72.62.42.7
Rest time, locomotor task time 20.00.00.1-0.2-0.20.2-0.20.3-0.00.2
Distance moved, locomotor task time 20.81.01.01.01.0-1.01.0-1.0-0.9-0.9
Vertical activity count, locomotor time 20.00.00.10.00.00.1-0.20.20.20.2
Light reinforcement 10.00.10.20.50.5-0.30.3-0.3-0.3-0.3
Light reinforcement 20.20.30.60.80.8-0.50.3-0.3-0.6-0.4
Bone: marrow area0.00.00.0-0.2-0.20.1-0.20.20.10.2
Bone: maximum diameter2.34.34.62.02.0-2.02.1-2.1-2.1-2.1
Bone: maximum force0.20.30.30.40.4-0.60.6-0.6-0.6-0.5
Bone: maximum moment0.20.40.50.50.5-0.70.7-0.7-0.7-0.6
Mean time between licks in bursts0.00.10.1-0.2-0.20.1-0.30.30.10.3
Mean num. licks in bursts3.25.15.3-2.3-2.32.3-2.32.22.32.2
Cd content in liver0.10.10.1-0.2-0.20.2-0.30.30.20.3
Co content in liver1.11.21.5-1.0-1.01.0-1.21.21.01.2
Cu content in liver0.40.50.70.80.8-0.80.7-0.6-0.8-0.6
Fe content in liver5.36.57.02.52.5-2.52.7-2.6-2.5-2.6
K content in liver0.20.20.20.40.4-0.40.4-0.4-0.4-0.4
Mg content in liver0.60.60.70.80.8-0.80.8-0.8-0.8-0.8
Mn content in liver1.01.11.21.11.1-1.11.1-1.0-1.1-1.0
Na content in liver0.10.10.20.20.2-0.30.5-0.5-0.2-0.4
Rb content in liver0.00.00.10.10.1-0.10.2-0.2-0.1-0.2
Se content in liver4.25.05.32.22.2-2.32.3-2.3-2.2-2.2
Sr content in liver0.10.00.10.20.2-0.20.2-0.2-0.2-0.2
Zn content in liver0.80.91.01.01.0-1.00.9-0.9-1.0-0.9
Bone: minimum diameter0.10.20.30.50.5-0.50.6-0.6-0.5-0.5
Time in familiar zone, hab. session 10.10.10.20.20.2-0.20.4-0.5-0.2-0.5
Time in novel zone, hab. session 10.80.81.01.01.0-1.00.8-0.8-1.0-0.7
Total zone transitions, hab. session 10.10.10.20.40.4-0.30.4-0.4-0.2-0.4
Total locomotion distance, hab. session 10.40.60.6-0.7-0.70.8-0.80.80.80.8
Locomotion velocity, hab. session 11.31.81.9-1.2-1.21.4-1.41.41.41.4
Time in familiar zone, hab. session 20.40.40.50.70.7-0.70.6-0.6-0.7-0.5
Time in novel zone, hab. session 20.20.20.3-0.6-0.60.5-0.30.20.50.2
Total zone transitions, hab. session 20.50.60.80.80.8-0.70.9-0.9-0.7-0.8
Total locomotion distance, hab. session 20.50.60.7-0.7-0.70.8-0.80.80.80.8
Locomotion velocity, hab. session 20.30.40.5-0.6-0.60.7-0.70.70.70.7
Novel to familiar place preference ratio0.40.40.50.60.6-0.50.7-0.7-0.5-0.7
Novelty place preference0.30.30.50.50.5-0.40.7-0.7-0.4-0.7
Time in novel zone, NPP test0.40.40.60.50.5-0.50.8-0.8-0.5-0.8
Total zone transitions, NPP test0.10.10.20.20.2-0.20.4-0.4-0.2-0.4
Total locomotion distance, NPP test0.00.10.10.10.1-0.10.4-0.4-0.1-0.4
Locomotion velocity, NPP test0.00.00.10.10.1-0.10.3-0.3-0.1-0.3
Intraocular pressure0.00.10.2-0.4-0.40.2-0.10.00.2-0.0
Delta distance traveled before/after self-admin1.51.52.0-1.0-1.01.2-1.41.41.21.3
Delta ambulatory time before/after self-admin0.30.40.5-0.5-0.50.7-0.70.70.70.6
Parametrial fat weight0.10.20.20.40.4-0.40.4-0.4-0.4-0.3
Pavlov. Cond. lever latency0.60.71.0-1.0-1.00.9-0.80.70.90.7
Pavlov. Cond. magazine entry latency0.10.10.20.40.4-0.40.2-0.2-0.4-0.1
Pavlov. Cond. change in total contacts0.50.50.8-0.6-0.60.7-0.90.90.70.8
Pavlov. Cond. index score0.30.40.60.80.8-0.70.5-0.5-0.6-0.5
Pavlov. Cond. latency score0.10.10.20.50.5-0.40.2-0.2-0.4-0.2
Pavlov. Cond. lever contacts0.40.50.70.80.8-0.80.6-0.5-0.8-0.5
Pavlov. Cond. magazine entry number0.00.10.1-0.3-0.30.3-0.10.00.2-0.0
Pavlov. Cond. intertrial magazine entries0.10.10.10.30.3-0.30.3-0.3-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.80.8-0.70.6-0.5-0.6-0.5
Pavlov. Cond. response bias0.91.11.41.21.2-1.10.9-0.9-1.1-0.8
Pavlov. Cond. lever latency0.00.00.0-0.1-0.10.1-0.20.20.10.2
Pavlov. Cond. magazine entry latency0.00.00.00.20.2-0.20.0-0.0-0.2-0.0
Pavlov. Cond. change in total contacts0.20.40.5-0.7-0.70.7-0.50.50.70.5
Pavlov. Cond. index score0.00.00.0-0.2-0.20.2-0.20.20.20.2
Pavlov. Cond. latency score0.10.10.1-0.3-0.30.3-0.30.30.30.3
Pavlov. Cond. lever contacts0.10.10.10.30.3-0.30.4-0.4-0.3-0.3
Pavlov. Cond. magazine entry number0.30.40.40.50.5-0.60.6-0.6-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.0-0.00.00.1-0.10.1-0.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.00.0-0.00.0-0.0-0.0-0.0
Pavlov. Cond. response bias0.00.00.0-0.0-0.00.0-0.00.00.0-0.0
Time in closed arm before self-admin1.01.31.81.31.3-1.21.1-1.1-0.9-1.0
Time in closed arm after self-admin1.01.01.4-1.0-1.01.0-1.00.91.21.0
Time in open arm before self-admin1.21.31.9-1.4-1.41.1-1.01.00.90.9
Time in open arm after self-admin0.10.10.1-0.2-0.20.1-0.30.3-0.20.2
Bone: periosteal estimation0.20.50.60.60.6-0.70.7-0.7-0.7-0.8
Bone: periosteal perimeter0.30.40.50.60.6-0.60.7-0.7-0.7-0.7
Bone: post-yield work0.71.01.2-0.9-0.91.0-1.11.11.01.1
Progressive ratio test 1 active lever presses3.13.84.52.12.1-2.01.9-1.9-1.9-1.8
Progressive ratio test 1 breakpoint2.93.54.32.12.1-2.01.8-1.7-1.8-1.7
Progressive ratio test 1 inactive lever presses1.72.53.31.81.8-1.51.4-1.4-1.5-1.4
Progressive ratio test 2 active lever presses3.13.64.62.12.1-2.01.7-1.7-1.8-1.7
Progressive ratio test 2 breakpoint3.54.05.02.22.2-2.11.8-1.8-1.9-1.7
Progressive ratio test 2 inactive lever presses0.50.71.41.21.2-0.90.5-0.5-0.9-0.5
Incentive Sensitization - Responses1.42.02.51.61.6-1.51.3-1.3-1.4-1.3
Incentive Sensitization - Breakpoint1.51.92.51.61.6-1.41.2-1.2-1.3-1.2
Sum of active levers in priming session hrs 5-60.30.30.5-0.7-0.70.4-0.50.50.20.4
Progressive ratio0.91.41.8-1.0-1.01.1-1.31.31.21.2
Food seeking constrained by brief footshock5.36.57.1-2.4-2.42.6-2.72.62.62.5
Seeking ratio, punishment vs. effort0.60.91.0-1.0-1.01.0-0.90.90.90.9
Retroperitoneal fat weight0.00.20.20.40.4-0.50.4-0.4-0.5-0.3
Reaction time number correct3.36.47.92.22.2-2.42.8-2.8-2.5-2.7
Reaction time mean minus median0.20.50.9-1.0-1.00.7-0.40.30.70.4
Reaction time mean minus median AUC0.00.10.2-0.2-0.2-0.00.4-0.4-0.0-0.3
Reaction time num false alarms5.17.28.32.92.9-2.82.5-2.5-2.7-2.4
Reaction time num false alarms AUC3.96.17.02.62.6-2.62.3-2.3-2.5-2.2
Reaction time trials correct on left3.36.47.92.22.2-2.42.8-2.8-2.5-2.7
Reaction time trials on left3.46.47.82.22.2-2.42.8-2.8-2.5-2.7
Reaction time mean1.42.32.7-1.7-1.71.5-1.41.41.51.4
Reaction time mean AUC1.11.82.2-1.5-1.51.3-1.31.31.31.3
Median of all reaction times1.72.42.5-1.6-1.61.5-1.61.61.51.5
Reaction time omissions0.00.00.10.00.0-0.10.0-0.0-0.30.1
Reaction time false alarm rate0.40.50.90.90.9-0.80.4-0.4-0.7-0.4
Reaction time premature initiation rate0.50.71.3-0.7-0.70.9-0.80.81.10.7
Reaction time premature initiations0.10.20.40.30.3-0.20.6-0.6-0.1-0.6
Std. dev. reaction times0.30.61.1-1.0-1.00.8-0.60.60.70.6
Reaction time trials completed3.46.47.82.22.2-2.42.8-2.8-2.5-2.7
Reaction time trials AUC4.17.99.52.52.5-2.73.1-3.1-2.8-3.0
Run reversals in cocaine runway, females0.30.30.4-0.4-0.40.6-0.50.50.60.6
Run reversals in cocaine runway, males0.40.50.50.60.6-0.70.7-0.7-0.7-0.7
Latency to leave start box in cocaine runway0.10.20.4-0.5-0.50.50.2-0.20.6-0.2
Latency to leave start box in cocaine runway, F0.30.30.80.10.1-0.10.8-0.90.2-0.9
Latency to leave start box in cocaine runway, M0.20.20.2-0.4-0.40.4-0.40.40.30.4
Std. dev. time between licks in bursts0.00.00.10.20.2-0.20.00.0-0.20.1
Total sessions with >9 infusions4.35.25.62.42.4-2.32.2-2.2-2.2-2.1
Short access day 1 total inactive lever presses1.31.73.01.71.7-1.30.9-0.8-1.4-0.8
Short access day 10 total inactive lever presses0.51.21.4-1.1-1.11.0-1.21.20.91.1
Short access day 1 total infusions2.33.03.31.81.8-1.81.7-1.6-1.7-1.6
Short access day 10 total infusions4.15.25.82.42.4-2.42.2-2.2-2.2-2.1
Short access total infusions2.83.54.32.12.1-2.01.8-1.7-1.8-1.7
Short access day 1 locomotion4.65.77.62.82.8-2.52.1-2.1-2.5-2.0
Short access day 10 total locomotion0.00.00.0-0.0-0.00.10.1-0.1-0.1-0.0
Short access total locomotion1.01.21.71.31.3-1.11.0-1.0-1.1-0.9
One hour access (0.3 mA shock)0.10.10.10.30.3-0.30.2-0.2-0.2-0.2
Compulsive drug intake0.10.10.3-0.3-0.3-0.10.5-0.5-0.3-0.5
One hour access (shock baseline)1.42.23.31.81.8-1.61.2-1.2-1.4-1.1
Social response proportion0.70.81.10.80.8-0.81.0-1.0-0.9-1.0
Social responses0.70.91.10.90.9-0.91.0-1.0-1.0-1.1
Social time3.95.36.2-2.4-2.42.5-2.22.22.32.2
Soleus weight0.10.40.40.60.6-0.60.6-0.6-0.6-0.5
Bone: stiffness0.81.31.51.11.1-1.11.2-1.2-1.0-1.1
Tibialis anterior weight3.411.612.53.53.5-3.53.4-3.3-3.4-3.2
Time to tail flick, vehicle, before self-admin2.82.93.31.71.7-1.71.8-1.8-1.4-1.8
Time to tail flick, vehicle, after self-admin0.10.10.3-0.6-0.60.30.1-0.10.2-0.1
Time to tail flick, test, before self-admin0.20.30.5-0.2-0.20.3-0.70.70.40.7
Time to tail flick, test, after self-admin0.20.20.4-0.1-0.10.4-0.40.50.60.5
Delta time to tail flick, vehicle, before/after SA0.40.41.0-1.0-1.00.7-0.40.30.30.4
Delta time to tail flick, test, before/after SA0.70.70.90.80.8-0.71.0-1.0-0.6-0.9
Tibia length0.41.01.51.21.2-1.00.9-0.8-0.9-0.8
Ambulatory time before self-admin0.00.00.1-0.1-0.10.2-0.00.00.30.1
Ambulatory time after self-admin0.60.81.5-0.8-0.81.0-0.70.71.20.7
Bone: tissue strength0.90.90.9-0.9-0.90.9-0.90.90.91.0
Total heroin consumption0.00.00.0-0.1-0.1-0.1-0.10.1-0.20.1
Bone: trabecular number0.00.10.10.00.00.1-0.30.40.00.4
Bone: trabecular spacing0.00.00.1-0.1-0.1-0.00.2-0.2-0.0-0.3
Bone: trabecular thickness1.51.92.11.51.5-1.41.4-1.3-1.4-1.2
Bone: trabecular tissue density0.30.40.60.60.6-0.60.7-0.8-0.5-0.7
Water consumed over 24 hours0.20.30.4-0.6-0.60.5-0.50.50.50.5
Number of responses in last shaping day3.43.74.41.91.9-2.11.9-1.9-2.1-1.8