Emc7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Emc7	0.03	0.02	1.1e-03	0.04	0.03	0.04	0.04	9.5e-05	4.8e-04	1.3e-04	5.4e-05
2	Brain	gene expression	Emc7	0.04	0.04	2.5e-03	0.02	0.03	0.02	0.02	5.0e-03	1.3e-03	1.2e-02	5.1e-03
3	IL	gene expression	Emc7	0.13	0.11	6.3e-03	0.08	0.08	0.09	0.09	7.1e-03	6.9e-03	3.7e-03	3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.4	0.8	1.0	-1.0	0.5	1.0
Area under the delay curve	0.3	0.4	0.5	0.3	-0.7	-0.7
BMI with tail	0.5	1.6	3.5	-1.1	1.9	0.4
BMI without tail	0.6	1.8	3.6	-1.3	1.9	0.5
Body weight	0.1	0.3	0.4	-0.7	0.5	0.4
Weight adjusted by age	0.4	0.5	0.9	0.7	-0.4	-1.0
Bone surface	0.6	1.1	1.3	-1.2	0.8	1.2
Bone volume	1.1	1.9	2.3	-1.5	1.1	1.5
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.4	-0.6	-0.3
Number of licking bursts	0.3	0.4	1.0	-0.5	0.2	1.0
Context. condit. distance diff. score	2.6	3.2	4.0	-1.9	1.4	2.0
Locomotion velocity, session 1	0.8	0.9	1.0	1.0	-1.0	-0.9
Locomotion distance, session 1	0.2	0.2	0.6	0.2	0.0	-0.7
Locomotion velocity, session 2	0.1	0.1	0.3	0.3	-0.1	-0.5
Locomotion distance, session 2	0.2	0.3	0.9	0.2	0.1	-0.9
Locomotion velocity, session 3	0.3	0.4	0.9	0.4	0.1	-1.0
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.0	-0.2
Stereotopy head waving bouts, day 3	2.1	2.5	3.2	-1.8	1.6	1.3
Stereotopy head waving duration, day 3	2.8	3.3	4.2	-2.0	1.9	1.5
Locomotion velocity, session 7	4.9	5.4	6.2	-2.5	2.3	2.2
Locomotion distance, session 7	2.9	3.7	4.5	-2.1	1.5	2.1
Stereotopy head waving bouts, day 7	1.1	1.2	1.8	1.0	-1.3	-0.8
Stereotopy head waving duration, day 7	0.9	1.0	1.5	1.0	-1.2	-0.7
Locomotion velocity, session 8	0.6	0.7	0.8	-0.9	0.9	0.7
Locomotion distance, session 8	1.3	2.0	2.6	-1.6	1.4	1.1
Degree of sensitization distance	2.7	2.8	3.7	-1.8	1.2	1.9
Degree of sensitization stereotypy	3.3	3.5	5.0	1.9	-2.2	-1.4
Conditioned locomotion	2.4	2.8	3.8	1.8	-1.1	-1.9
Cocaine response after cond. corrected	0.8	0.9	1.9	0.8	-0.4	-1.4
Cocaine response after cond. not corrected	0.4	0.5	1.0	0.6	-0.4	-1.0
Cocaine response before conditioning	0.2	0.2	0.4	-0.4	0.0	0.6
Saline control response	0.0	0.0	0.0	0.0	-0.1	0.1
Bone: connectivity density	0.5	0.7	1.0	-1.0	0.7	0.9
Bone: cortical apparent density	2.5	3.5	5.6	2.0	-2.4	-0.8
Bone: cortical area	0.6	0.9	1.4	-0.9	1.2	0.7
Bone: cortical porosity	0.8	0.8	1.8	0.8	0.1	-1.3
Bone: cortical porosity	0.7	0.7	1.6	0.7	0.2	-1.3
Bone: cortical thickness	0.0	0.1	0.1	0.1	-0.3	0.3
Bone: cortical thickness	1.7	2.0	2.4	1.5	-1.3	-1.5
Bone: cortical tissue density	3.0	4.1	6.4	2.2	-2.5	-0.9
Condit. Reinf. active minus inactive responses	0.9	1.0	2.4	-0.8	0.2	1.5
Condit. Reinf. active-inactive response ratio	3.1	3.4	4.7	-1.8	1.5	2.2
Condit. Reinf. active responses	0.5	0.6	1.3	-0.2	-0.7	1.1
Condit. Reinf. inactive responses	1.8	2.2	3.8	1.5	-2.0	-0.8
Incentive salience index mean	1.5	1.9	3.9	-1.2	0.5	2.0
Condit. Reinf. lever presses	0.9	1.3	2.7	-1.1	0.2	1.7
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	-0.9	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.8	1.0	1.3	-1.0	1.2	0.8
Condit. Reinf. active responses	0.8	1.2	2.1	-1.1	0.6	1.5
Condit. Reinf. inactive responses	1.4	1.9	3.9	-1.2	0.4	2.0
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.0	-0.5	0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	-0.7	0.1	1.1
Conditioned reinforcement - actives	0.7	1.2	2.1	1.1	-1.5	-0.6
Conditioned reinforcement - inactives	1.0	1.5	1.9	1.3	-1.4	-1.0
Conditioned locomotion	0.1	0.1	0.3	0.1	-0.5	-0.2
Patch foraging indifference point 0 sec	1.6	3.0	3.5	-1.7	1.6	1.9
Patch foraging indifference point AUC	1.2	1.7	2.2	1.5	-1.5	-0.8
Delay disc. indifference point, 0s delay	1.6	1.8	2.2	1.3	-1.3	-1.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.1	0.4	-0.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.5	0.0	0.0
Delay disc. indifference point, 24s delay	0.4	0.5	0.7	0.7	-0.8	-0.6
Delay disc. indifference point, 4s delay	1.3	1.4	1.5	1.2	-1.2	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.2	-0.3	-0.2
Indifference point function ln k	0.8	1.3	2.3	-1.2	1.5	0.4
Indifference point function log k	0.8	1.3	2.3	-1.2	1.5	0.4
Patch foraging total patch changes 0 sec	1.3	2.5	3.3	-1.5	1.4	1.8
Patch foraging total patch changes 12 sec	0.8	1.0	1.2	-1.0	0.9	1.1
Patch foraging total patch changes 18 sec	0.7	1.1	1.8	1.2	-1.3	-0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.2	-0.3	0.2
Patch foraging total patch changes 6 sec	0.8	1.3	2.4	-0.8	0.8	1.5
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.5	0.5	0.3
Patch foraging water rate 0 sec	1.0	2.2	2.6	-1.5	1.3	1.6
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.3	-0.0	0.0
Patch foraging water rate 18 sec	0.2	0.3	0.5	-0.5	0.7	0.5
Patch foraging water rate 24 sec	0.5	0.8	1.4	-0.7	0.6	1.2
Patch foraging water rate 6 sec	0.0	0.0	0.0	0.1	-0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.1	-0.7	0.7	1.0
Distance traveled before self-admin	1.1	1.5	3.3	1.0	-1.8	-0.4
Distance traveled after self-admin	0.2	0.2	0.4	-0.4	0.1	0.6
Extensor digitorum longus weight	0.3	1.1	1.6	1.3	-1.0	-0.9
Bone: elastic displacement	0.1	0.1	0.2	0.0	-0.4	0.5
Bone: elastic work	0.0	0.1	0.2	-0.1	0.1	0.4
Bone: endosteal estimation	0.7	1.6	3.0	-1.2	1.7	0.6
Bone: endosteal perimeter	0.5	1.1	2.5	-0.9	1.6	-0.0
Epididymis fat weight	1.5	5.0	8.0	-2.3	2.8	1.4
Delta time in closed arm before/after self-admin	0.6	0.6	0.7	-0.7	0.9	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.2	-0.4	-0.2
Diff in mean of infusions in LGA sessions	2.4	3.0	3.6	-1.8	1.9	1.4
Delay discount exponential model param	0.2	0.2	0.3	-0.1	0.6	0.4
Extinction: sum of active levers before priming	0.1	0.2	0.2	0.5	-0.5	-0.1
Active lever presses in extinction session 6	0.7	0.7	1.2	0.8	-0.4	-1.1
Bone: final force	1.7	2.7	3.6	-1.6	1.9	1.3
Bone: final moment	1.6	2.5	3.6	-1.5	1.9	1.3
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.0	-0.0	0.3
Glucose	0.7	1.2	2.0	-1.2	1.4	0.3
Heart weight	0.3	0.5	1.0	0.3	0.6	-1.0
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.0	0.6	0.4
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.3	-0.5	-0.1
Intermittent access intake escalation	0.1	0.3	0.5	0.5	-0.7	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.4	0.4	-0.6	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	-0.3
Intermitt. access day 15 inactive lever presses	1.2	2.4	2.9	1.5	-1.7	-1.4
Intermitt. access escalation Index	0.8	1.2	1.5	-1.2	1.2	0.7
Intermittent access day 1 total infusions	0.7	1.2	1.7	0.9	-1.3	-1.0
Intermittent access day 15 total infusions	0.8	1.2	1.7	1.0	-1.3	-1.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	0.3	-0.7	-0.5
Intermittent access total infusions	0.5	0.6	0.8	0.6	-0.9	-0.8
Intermittent access day 1 locomotion	0.3	0.4	0.8	0.4	-0.9	-0.4
Intermittent access day 15 total locomotion	0.1	0.2	0.5	0.2	-0.7	-0.2
Intermittent access total locomotion	1.9	2.3	3.6	1.4	-1.9	-1.1
Intermittent access standard deviation	0.2	0.3	0.7	0.4	-0.8	-0.3
Left kidney weight	0.9	4.2	5.6	-2.4	2.3	1.4
Right kidney weight	1.3	5.9	7.7	-2.8	2.5	2.0
Cocaine induced anxiety	0.7	1.0	1.7	-1.1	1.3	0.5
Post-drug Anxiety	4.1	4.4	5.8	-2.4	1.9	2.0
Baseline Anxiety	1.2	1.4	1.8	-1.3	0.9	1.3
Tail length	0.4	1.5	1.8	1.3	-1.2	-1.2
Length with tail	0.1	0.5	1.4	0.4	-1.2	-0.2
Length without tail	0.1	0.3	0.9	0.1	-0.9	0.2
Times rat made contact with spout	1.2	1.4	2.1	-1.1	1.4	1.0
Lifetime Intake	0.3	0.4	0.7	0.4	-0.8	-0.5
Liver weight, left	2.1	3.5	3.9	-2.0	1.8	1.8
Liver weight, right	2.8	4.8	5.9	-2.3	1.8	2.4
Locomotor activity	0.4	0.7	1.1	1.1	-0.2	-0.9
Locomotor testing distance	0.1	0.2	0.5	0.0	0.7	0.0
Locomotor testing rearing	0.0	0.0	0.0	0.0	0.1	-0.0
Locomotion in novel chamber	0.1	0.2	0.4	-0.4	0.6	0.1
Locomotion in novel chamber post-restriction	0.5	0.8	1.2	1.1	-0.8	-0.8
Fecal boli incidents, locomotor time 1	1.1	1.5	1.6	1.2	-1.3	-1.3
Change in fecal boli incidents, locomotor task	1.1	1.1	2.3	-0.9	1.5	0.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	0.4	-0.2	-0.7
Bouts of movement, locomotor time 1	7.4	8.4	10.7	3.2	-3.3	-2.1
Total resting periods, locomotor time 1	6.7	7.5	9.2	3.0	-3.0	-2.1
Rest time, locomotor task time 1	1.1	1.3	1.4	1.2	-1.1	-1.1
Distance moved, locomotor task time 1	2.1	3.1	3.9	-2.0	1.4	1.9
Vertical activity count, locomotor time 1	1.7	4.2	4.7	-2.2	1.8	2.2
Time >=10cm from walls, locomotor time 2	1.9	2.8	4.0	-1.9	0.8	2.0
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.5	-0.8	0.1
Total resting periods, locomotor time 2	0.3	0.5	1.0	0.7	-1.0	-0.2
Rest time, locomotor task time 2	3.1	3.9	5.4	2.3	-1.2	-2.2
Distance moved, locomotor task time 2	5.2	6.2	9.3	-2.7	1.5	3.0
Vertical activity count, locomotor time 2	5.6	7.7	11.8	-3.0	1.6	3.4
Light reinforcement 1	0.1	0.3	0.8	-0.2	-0.4	0.9
Light reinforcement 2	0.2	0.3	0.6	0.4	-0.8	0.0
Bone: marrow area	0.7	1.5	2.8	-1.1	1.7	0.6
Bone: maximum diameter	0.8	1.5	3.1	-1.1	1.8	0.4
Bone: maximum force	1.9	3.4	4.5	-1.8	2.1	1.5
Bone: maximum moment	1.7	3.0	4.2	-1.7	2.0	1.4
Mean time between licks in bursts	1.2	3.0	3.8	1.9	-1.5	-1.8
Mean num. licks in bursts	0.1	0.2	0.4	-0.2	0.6	-0.3
Cd content in liver	0.1	0.2	0.3	-0.3	0.5	0.3
Co content in liver	1.3	1.5	2.6	1.1	-0.7	-1.6
Cu content in liver	2.8	3.3	3.7	1.9	-1.6	-1.9
Fe content in liver	0.2	0.2	0.3	-0.4	0.5	0.3
K content in liver	0.9	0.8	1.4	0.9	-0.6	-1.2
Mg content in liver	2.6	2.6	2.9	1.7	-1.6	-1.6
Mn content in liver	0.9	1.0	1.2	1.0	-1.1	-0.9
Na content in liver	2.3	2.4	3.2	-1.8	1.5	1.3
Rb content in liver	2.3	2.7	5.2	1.5	-2.3	-0.9
Se content in liver	2.3	2.7	3.9	1.7	-2.0	-1.0
Sr content in liver	0.5	0.4	0.7	-0.6	0.8	0.4
Zn content in liver	1.8	2.0	2.3	1.5	-1.3	-1.4
Bone: minimum diameter	2.1	3.8	6.1	-2.0	2.5	1.1
Time in familiar zone, hab. session 1	1.0	0.9	1.2	1.1	-0.6	-1.1
Time in novel zone, hab. session 1	1.5	1.5	2.1	-1.4	1.2	1.1
Total zone transitions, hab. session 1	0.2	0.2	0.6	0.2	0.0	-0.8
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.1	0.4	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.2	0.1	-0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	-0.4	0.1
Time in novel zone, hab. session 2	0.4	0.5	0.8	-0.7	0.9	0.4
Total zone transitions, hab. session 2	0.9	1.2	2.1	1.0	-0.7	-1.4
Total locomotion distance, hab. session 2	0.7	1.0	1.7	1.0	-0.6	-1.3
Locomotion velocity, hab. session 2	0.7	0.9	1.6	0.9	-0.5	-1.3
Novel to familiar place preference ratio	2.2	2.4	4.1	-1.6	2.0	0.8
Novelty place preference	2.3	2.5	4.3	-1.6	2.1	0.7
Time in novel zone, NPP test	1.8	1.9	3.0	-1.5	1.7	0.8
Total zone transitions, NPP test	4.4	6.4	7.1	2.7	-2.4	-2.5
Total locomotion distance, NPP test	2.5	3.4	4.0	1.9	-1.6	-2.0
Locomotion velocity, NPP test	2.7	3.7	4.9	2.1	-1.4	-2.2
Intraocular pressure	0.3	0.4	0.7	-0.8	0.8	0.1
Delta distance traveled before/after self-admin	0.3	0.4	0.9	-0.4	0.9	0.2
Delta ambulatory time before/after self-admin	1.1	1.4	2.2	-1.1	1.5	0.9
Parametrial fat weight	0.2	0.4	0.9	0.3	-0.2	-1.0
Pavlov. Cond. lever latency	1.7	2.2	2.6	1.6	-1.2	-1.6
Pavlov. Cond. magazine entry latency	5.2	6.7	8.2	-2.9	2.0	2.8
Pavlov. Cond. change in total contacts	3.6	3.8	4.8	-2.1	1.5	2.2
Pavlov. Cond. index score	4.0	5.1	6.3	-2.5	1.7	2.5
Pavlov. Cond. latency score	3.6	4.6	5.6	-2.4	1.7	2.3
Pavlov. Cond. lever contacts	2.1	2.4	2.9	-1.7	1.3	1.7
Pavlov. Cond. magazine entry number	6.2	7.8	9.4	3.1	-2.3	-3.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	0.8	-0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.6	5.7	-2.3	1.6	2.4
Pavlov. Cond. response bias	3.1	3.8	5.0	-2.1	1.4	2.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.3	-0.4	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.2	-0.3	0.3
Pavlov. Cond. change in total contacts	0.2	0.4	0.6	-0.6	0.5	0.8
Pavlov. Cond. index score	0.2	0.3	0.6	-0.5	0.4	0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.4	0.3	0.7
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.6	0.7	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.2	0.1	-0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.2	-0.8	0.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.6	-0.5	0.4	0.8
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.4	0.4	0.6
Time in closed arm before self-admin	0.7	1.0	1.6	-1.0	0.4	1.3
Time in closed arm after self-admin	0.6	0.6	0.9	-0.9	0.5	0.9
Time in open arm before self-admin	0.1	0.1	0.3	0.2	0.0	-0.5
Time in open arm after self-admin	0.1	0.1	0.1	-0.3	0.3	-0.2
Bone: periosteal estimation	0.7	1.4	2.7	-1.1	1.6	0.6
Bone: periosteal perimeter	0.7	1.3	3.1	-0.8	1.8	-0.2
Bone: post-yield work	0.2	0.3	0.4	0.2	0.7	-0.6
Progressive ratio test 1 active lever presses	0.2	0.2	0.7	0.2	-0.8	0.0
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.3	-0.9	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.9	0.4	-1.0	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.5	-0.0	0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.5	-0.0	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.1	-0.4	0.0
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.3	0.2	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.5	0.2	0.0
Sum of active levers in priming session hrs 5-6	2.7	2.5	3.7	1.9	-1.8	-0.7
Progressive ratio	1.4	2.2	2.9	1.7	-1.4	-1.3
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	-0.1	0.1
Seeking ratio, punishment vs. effort	0.6	0.8	1.2	-1.1	0.8	0.8
Retroperitoneal fat weight	6.8	29.2	34.7	-5.9	5.8	4.4
Reaction time number correct	0.4	0.9	0.9	-0.9	0.9	1.0
Reaction time mean minus median	0.0	0.0	0.0	-0.2	-0.0	-0.1
Reaction time mean minus median AUC	0.3	0.7	1.1	-0.9	1.0	0.4
Reaction time num false alarms	0.3	0.4	0.8	0.1	0.6	-0.9
Reaction time num false alarms AUC	0.2	0.4	0.6	-0.2	0.8	-0.7
Reaction time trials correct on left	0.4	0.9	0.9	-0.9	0.9	1.0
Reaction time trials on left	0.5	0.9	0.9	-1.0	0.9	1.0
Reaction time mean	0.5	0.8	1.0	-1.0	0.6	0.9
Reaction time mean AUC	0.4	0.7	0.9	-1.0	0.7	0.8
Median of all reaction times	0.6	0.9	1.1	-1.0	0.7	1.0
Reaction time omissions	0.1	0.1	0.1	-0.4	0.1	0.3
Reaction time false alarm rate	0.5	0.7	1.8	0.5	0.2	-1.4
Reaction time premature initiation rate	1.1	1.5	1.8	-1.2	1.1	1.3
Reaction time premature initiations	1.8	3.2	3.9	-1.8	1.5	2.0
Std. dev. reaction times	0.4	0.7	1.0	-1.0	0.9	0.4
Reaction time trials completed	0.5	0.9	0.9	-1.0	0.9	1.0
Reaction time trials AUC	0.6	1.2	1.5	-1.1	0.9	1.2
Run reversals in cocaine runway, females	3.1	3.1	3.8	-2.0	1.9	1.3
Run reversals in cocaine runway, males	0.7	0.7	1.0	1.0	-0.8	-0.6
Latency to leave start box in cocaine runway	0.7	0.8	0.9	0.9	-1.0	-0.8
Latency to leave start box in cocaine runway, F	1.2	1.4	1.7	1.1	-1.3	-1.1
Latency to leave start box in cocaine runway, M	0.5	0.4	0.8	-0.5	0.9	0.5
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.4	0.5	0.2
Total sessions with >9 infusions	0.3	0.3	0.8	0.4	-0.9	-0.2
Short access day 1 total inactive lever presses	0.9	1.1	1.4	1.2	-0.9	-1.1
Short access day 10 total inactive lever presses	0.1	0.3	0.5	0.5	-0.3	-0.7
Short access day 1 total infusions	0.5	0.6	1.5	0.5	-1.2	0.1
Short access day 10 total infusions	0.4	0.6	1.0	0.6	-1.0	-0.6
Short access total infusions	0.3	0.4	1.0	0.4	-1.0	-0.1
Short access day 1 locomotion	0.2	0.2	0.3	-0.1	-0.5	0.5
Short access day 10 total locomotion	1.6	3.0	3.3	1.8	-1.7	-1.7
Short access total locomotion	0.2	0.3	0.4	0.4	-0.6	-0.5
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.3	-0.4	-0.6
Compulsive drug intake	0.4	0.5	1.1	0.5	0.0	-1.0
One hour access (shock baseline)	0.1	0.1	0.3	-0.5	0.1	0.3
Social response proportion	3.5	4.0	5.6	-2.3	1.0	2.4
Social responses	2.5	3.2	5.1	-2.0	0.9	2.3
Social time	0.6	0.8	1.1	0.8	-0.8	-1.0
Soleus weight	0.3	0.9	1.9	-0.8	1.4	-0.0
Bone: stiffness	2.8	4.5	6.8	-2.1	2.6	1.5
Tibialis anterior weight	0.1	0.3	0.4	0.6	-0.5	-0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.6	0.2	0.7
Time to tail flick, vehicle, after self-admin	2.3	3.0	3.6	-1.9	1.9	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.4	0.2	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.4	-0.6	-0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	1.2	-0.9	1.1	0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.2	-0.3
Tibia length	0.1	0.1	0.2	0.5	-0.4	-0.3
Ambulatory time before self-admin	1.3	1.9	3.8	1.3	-1.9	-0.5
Ambulatory time after self-admin	0.2	0.2	0.5	-0.2	-0.1	0.7
Bone: tissue strength	0.7	0.7	1.1	1.0	-0.6	-0.9
Total heroin consumption	1.7	2.0	2.4	1.6	-1.5	-1.2
Bone: trabecular number	0.1	0.1	0.2	-0.2	-0.3	0.4
Bone: trabecular spacing	1.8	2.3	2.7	-1.6	1.5	1.4
Bone: trabecular thickness	0.0	0.1	0.1	0.1	-0.3	0.2
Bone: trabecular tissue density	0.3	0.5	0.8	0.8	-0.9	-0.1
Water consumed over 24 hours	1.3	1.7	3.0	-1.3	0.8	1.7
Number of responses in last shaping day	0.3	0.3	0.4	-0.6	0.4	0.6