Hub : Genes

Emc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative polyA XM_006239245.4 0.09 0.11 4.6e-04 0.03 0.03 0.03 0.02 5.5e-04 6.0e-04 2.3e-04 6.9e-04
2 Adipose mRNA stability Emc1 0.05 0.05 6.4e-06 0.04 0.03 0.04 0.04 3.2e-05 1.6e-04 6.5e-05 5.7e-05
3 Brain alternative polyA NM_001108690.1 0.04 0.04 1.6e-04 0.03 0.03 0.04 0.03 5.1e-04 4.4e-04 3.3e-04 9.4e-04
4 NAcc alternative polyA NM_001108690.1 0.04 0.05 1.6e-03 0.02 0.02 0.03 0.02 7.7e-04 1.6e-03 2.1e-04 1.0e-03
5 PL gene expression Emc1 0.02 0.02 3.3e-03 0.02 0.01 0.02 0.01 6.8e-03 1.1e-02 5.4e-03 7.6e-03
6 Adipose alternative polyA NM_001108690.1 0.04 0.04 1.6e-04 0.02 0.03 0.02 0.02 2.2e-03 4.1e-04 1.4e-03 1.5e-03
7 Adipose alternative polyA XM_006239245.4 0.04 0.04 1.0e-04 0.02 0.03 0.03 0.03 1.5e-03 2.5e-04 7.9e-04 6.8e-04
8 Liver gene expression Emc1 0.14 0.1 5.6e-17 0.12 0.14 0.12 0.13 1.1e-13 7.8e-15 5.6e-13 8.0e-14
9 Brain isoform ratio XM_006239245.4 0.04 0.03 4.4e-04 0.01 0.02 0.02 0.01 1.4e-02 2.8e-03 7.1e-03 1.3e-02
10 BLA alternative polyA NM_001108690.1 0.12 0.12 7.8e-03 0.04 0.03 0.02 0.04 4.1e-03 1.1e-02 2.0e-02 5.7e-03
11 Brain isoform ratio NM_001108690.1 0.03 0.03 1.2e-03 0.01 0.02 0.01 0.01 3.0e-02 8.5e-03 1.5e-02 2.2e-02
12 Brain alternative polyA XM_006239245.4 0.04 0.04 1.3e-04 0.03 0.04 0.04 0.03 5.3e-04 2.3e-04 2.4e-04 6.4e-04
13 BLA gene expression Emc1 0.06 0.05 1.8e-03 0.03 0.04 0.02 0.03 8.2e-03 5.3e-03 4.4e-02 1.1e-02
14 Brain gene expression Emc1 0.05 0.03 1.3e-05 0.06 0.06 0.06 0.06 6.0e-06 4.9e-06 4.8e-06 6.9e-06
15 Adipose gene expression Emc1 0.35 0.27 6.8e-12 0.08 0.08 0.06 0.08 6.3e-09 1.2e-09 9.9e-08 2.8e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.51.2-0.8-1.00.90.7-0.7-0.60.60.60.6-0.1-0.70.70.8-0.41.1
Area under the delay curve0.10.10.80.9-0.20.4-0.10.0-0.00.00.00.10.1-0.10.10.1-0.2-0.1
BMI with tail0.61.92.81.71.0-1.1-1.61.51.4-1.4-1.4-1.4-1.61.4-1.3-1.21.5-0.9
BMI without tail0.71.53.92.00.8-0.9-1.41.31.2-1.2-1.1-1.2-0.71.2-1.2-1.21.2-1.3
Body weight2.18.710.12.72.8-3.0-3.23.23.0-3.0-3.0-3.1-2.43.1-3.0-3.03.1-2.8
Weight adjusted by age0.20.20.70.80.1-0.4-0.60.50.5-0.5-0.5-0.5-0.80.4-0.4-0.40.4-0.3
Bone surface0.10.20.70.20.2-0.2-0.40.40.5-0.5-0.5-0.4-0.80.4-0.4-0.30.6-0.1
Bone volume0.00.00.2-0.3-0.30.30.1-0.10.00.0-0.00.0-0.5-0.10.10.10.20.4
Breakpoint value in progressive ratio session0.20.21.51.2-0.40.50.2-0.2-0.40.40.40.40.7-0.40.40.4-0.50.1
Number of licking bursts3.03.69.3-3.1-1.71.81.9-1.9-1.81.81.81.81.1-1.81.81.9-1.62.2
Context. condit. distance diff. score0.20.20.50.10.6-0.7-0.50.50.4-0.4-0.4-0.50.10.6-0.6-0.60.5-0.6
Locomotion velocity, session 11.82.04.7-0.4-1.11.31.4-1.4-1.61.61.61.52.2-1.41.41.3-1.50.8
Locomotion distance, session 17.69.715.5-2.7-2.82.93.2-3.1-3.43.33.33.23.9-3.13.02.9-3.12.4
Locomotion velocity, session 28.610.011.1-2.4-3.13.33.3-3.3-3.33.33.33.32.7-3.33.33.3-3.23.2
Locomotion distance, session 23.14.35.3-0.2-2.32.32.1-2.1-2.22.22.22.22.3-2.12.12.1-2.11.7
Locomotion velocity, session 30.91.11.6-0.4-1.31.11.0-1.1-1.11.11.11.01.1-1.01.01.0-1.01.0
Locomotion distance, session 32.12.33.6-0.7-1.91.71.5-1.6-1.51.51.51.51.1-1.51.51.6-1.41.7
Stereotopy head waving bouts, day 31.11.32.90.71.5-1.3-1.01.11.0-1.0-1.0-1.10.11.1-1.2-1.31.0-1.7
Stereotopy head waving duration, day 30.20.20.6-0.20.8-0.7-0.20.40.3-0.3-0.3-0.40.40.4-0.4-0.50.3-0.8
Locomotion velocity, session 70.10.10.5-0.5-0.70.50.2-0.3-0.20.20.20.2-0.3-0.20.30.3-0.30.6
Locomotion distance, session 73.64.67.1-2.0-2.62.32.2-2.2-2.12.12.02.10.9-2.12.22.3-2.02.7
Stereotopy head waving bouts, day 70.20.30.80.80.5-0.6-0.50.50.3-0.3-0.3-0.40.60.4-0.5-0.50.4-0.9
Stereotopy head waving duration, day 70.20.20.80.70.5-0.5-0.40.40.2-0.2-0.2-0.30.90.4-0.4-0.50.2-0.9
Locomotion velocity, session 80.20.20.30.4-0.60.50.3-0.3-0.50.50.50.40.3-0.40.40.5-0.40.5
Locomotion distance, session 80.71.01.8-0.2-1.10.91.0-1.0-1.11.11.11.01.4-0.91.01.0-1.10.8
Degree of sensitization distance0.10.10.2-0.3-0.30.30.2-0.2-0.20.20.20.2-0.2-0.20.30.3-0.30.4
Degree of sensitization stereotypy0.80.91.71.20.8-0.9-1.01.00.8-0.8-0.8-0.90.11.0-1.0-1.00.9-1.3
Conditioned locomotion0.10.10.3-0.5-0.30.30.3-0.3-0.20.20.10.2-0.1-0.20.20.2-0.30.3
Cocaine response after cond. corrected0.20.20.9-0.9-0.40.40.4-0.4-0.20.30.20.3-0.6-0.40.40.5-0.30.8
Cocaine response after cond. not corrected0.10.20.5-0.7-0.30.40.3-0.3-0.20.20.20.2-0.5-0.30.30.4-0.30.7
Cocaine response before conditioning0.10.10.30.1-0.20.30.1-0.1-0.30.30.30.20.6-0.20.20.2-0.3-0.1
Saline control response1.01.42.6-1.3-1.21.21.1-1.2-1.11.11.11.10.1-1.21.21.3-1.11.6
Bone: connectivity density0.00.00.20.5-0.10.1-0.20.10.1-0.1-0.1-0.1-0.10.1-0.1-0.10.3-0.1
Bone: cortical apparent density0.70.91.3-0.3-1.11.11.0-1.0-0.90.90.91.01.0-1.01.00.9-0.90.8
Bone: cortical area0.60.91.40.60.9-1.0-1.01.01.0-1.0-1.0-1.0-0.61.0-1.0-1.11.0-1.2
Bone: cortical porosity0.30.30.4-0.5-0.60.60.6-0.5-0.60.60.60.60.6-0.50.60.6-0.50.5
Bone: cortical porosity0.10.10.2-0.5-0.20.30.3-0.3-0.30.30.30.30.2-0.30.30.3-0.20.3
Bone: cortical thickness0.00.00.2-0.1-0.20.10.1-0.1-0.10.10.10.10.5-0.10.1-0.0-0.0-0.3
Bone: cortical thickness0.60.81.20.50.7-0.8-0.90.80.9-0.9-1.0-0.9-1.10.9-0.9-0.91.0-0.7
Bone: cortical tissue density0.81.01.4-0.3-1.21.21.0-1.1-1.01.01.01.01.0-1.11.01.0-1.00.9
Condit. Reinf. active minus inactive responses5.86.511.9-3.4-2.52.52.6-2.6-2.52.52.42.51.7-2.52.52.5-2.62.7
Condit. Reinf. active-inactive response ratio3.63.97.4-2.7-2.02.01.9-2.0-1.81.81.81.90.5-1.91.92.1-2.02.5
Condit. Reinf. active responses6.07.416.8-4.1-2.62.52.8-2.7-2.62.62.62.62.0-2.72.62.6-2.62.7
Condit. Reinf. inactive responses0.30.42.3-1.5-0.40.20.7-0.5-0.50.50.50.51.0-0.50.40.3-0.40.0
Incentive salience index mean3.03.67.6-2.8-1.81.81.9-1.9-1.81.81.81.81.6-1.81.81.8-1.91.7
Condit. Reinf. lever presses0.40.52.2-1.5-0.60.60.7-0.7-0.60.60.60.60.7-0.60.50.5-0.80.4
Condit. Reinf. active minus inactive responses1.31.63.11.31.0-1.0-1.31.21.4-1.3-1.4-1.3-1.71.3-1.2-1.11.2-0.8
Condit. Reinf. active-inactive response ratio0.10.10.50.30.3-0.3-0.40.30.4-0.4-0.4-0.4-0.70.4-0.3-0.30.3-0.0
Condit. Reinf. active responses0.20.21.30.60.1-0.1-0.40.30.5-0.5-0.5-0.4-1.10.4-0.3-0.30.30.1
Condit. Reinf. inactive responses0.70.91.3-0.6-1.11.10.9-1.0-0.90.90.91.00.4-1.01.01.0-1.11.0
Condit. Reinf. lever presses0.30.42.21.50.3-0.3-0.60.60.6-0.6-0.6-0.5-0.60.5-0.5-0.50.4-0.6
Condit. Reinf. lever reinforcers received0.50.71.81.00.5-0.5-0.80.70.9-0.9-0.9-0.8-1.30.8-0.7-0.70.7-0.4
Conditioned reinforcement - actives0.70.73.91.8-2.01.60.10.0-0.30.30.40.40.5-0.40.40.4-0.40.1
Conditioned reinforcement - inactives0.00.00.1-0.00.1-0.20.0-0.10.0-0.0-0.0-0.00.10.0-0.1-0.10.3-0.1
Conditioned locomotion0.80.93.61.2-1.91.60.6-0.7-0.80.80.80.80.8-0.80.80.8-0.60.6
Patch foraging indifference point 0 sec2.54.15.1-0.8-2.32.12.1-2.1-2.12.12.12.11.8-2.12.12.1-2.01.9
Patch foraging indifference point AUC0.30.30.50.6-0.70.70.5-0.4-0.60.60.60.60.6-0.60.60.6-0.60.5
Delay disc. indifference point, 0s delay2.12.34.41.1-2.02.11.1-1.3-1.41.41.51.50.9-1.51.61.7-1.81.5
Delay disc. indifference point, 16s delay0.00.00.20.50.3-0.0-0.20.20.2-0.2-0.1-0.1-0.30.1-0.1-0.10.0-0.1
Delay disc. indifference point, 2s delay0.30.33.51.9-0.30.4-0.50.40.3-0.3-0.2-0.2-0.40.2-0.1-0.1-0.0-0.2
Delay disc. indifference point, 24s delay0.30.30.60.4-0.60.70.4-0.5-0.50.50.60.60.2-0.60.70.7-0.70.5
Delay disc. indifference point, 4s delay0.10.20.50.70.0-0.1-0.50.40.4-0.4-0.4-0.4-0.40.4-0.4-0.40.3-0.4
Delay disc. indifference point, 8s delay0.10.10.20.00.4-0.1-0.10.10.2-0.2-0.2-0.20.20.2-0.2-0.30.2-0.4
Indifference point function ln k0.10.21.1-1.10.1-0.10.4-0.4-0.30.30.30.21.0-0.20.20.1-0.1-0.2
Indifference point function log k0.10.21.1-1.10.1-0.10.4-0.4-0.30.30.30.21.0-0.20.20.1-0.1-0.2
Patch foraging total patch changes 0 sec2.84.45.6-0.8-2.42.32.2-2.2-2.22.22.22.21.9-2.22.22.2-2.12.0
Patch foraging total patch changes 12 sec2.02.63.6-0.4-1.91.81.6-1.6-1.61.61.61.71.1-1.71.71.7-1.61.8
Patch foraging total patch changes 18 sec4.66.07.4-0.6-2.72.52.5-2.5-2.62.62.62.62.3-2.62.62.5-2.42.4
Patch foraging total patch changes 24 sec4.45.47.0-0.2-2.72.62.2-2.2-2.32.32.42.41.4-2.52.52.6-2.52.6
Patch foraging total patch changes 6 sec1.62.43.1-0.8-1.71.71.6-1.6-1.61.61.61.60.9-1.61.71.7-1.61.8
Patch foraging time to switch 0 sec0.71.12.1-0.21.1-1.0-1.00.91.1-1.1-1.1-1.1-1.51.1-1.1-1.01.1-0.7
Patch foraging water rate 0 sec2.13.44.5-0.9-1.91.91.9-1.8-2.02.02.01.92.1-1.91.91.9-1.91.5
Patch foraging water rate 12 sec2.64.04.7-1.3-2.02.02.1-2.2-2.02.02.02.11.4-2.12.12.1-1.92.2
Patch foraging water rate 18 sec1.21.63.1-1.8-1.11.01.3-1.4-1.31.31.21.21.1-1.21.21.2-1.11.3
Patch foraging water rate 24 sec2.12.95.0-2.2-1.51.41.9-1.9-1.71.81.71.71.4-1.71.71.7-1.51.8
Patch foraging water rate 6 sec2.63.85.5-0.6-2.02.02.0-1.9-2.12.12.12.12.3-2.02.02.0-2.01.6
Seeking ratio, delayed vs. immediate footshock3.13.54.61.52.0-1.9-2.02.11.9-1.9-1.9-1.9-1.31.9-1.9-2.01.9-2.1
Distance traveled before self-admin0.50.52.31.20.5-0.6-0.40.50.3-0.3-0.2-0.31.30.4-0.5-0.70.4-1.5
Distance traveled after self-admin0.20.31.5-0.70.6-0.60.1-0.00.0-0.1-0.1-0.11.20.2-0.3-0.40.2-0.9
Extensor digitorum longus weight0.00.00.3-0.30.1-0.20.00.0-0.10.10.10.00.50.0-0.0-0.10.0-0.2
Bone: elastic displacement7.48.49.5-2.3-3.03.02.9-2.9-3.03.03.03.02.7-3.03.02.9-3.12.6
Bone: elastic work3.03.84.6-1.6-2.12.12.0-2.0-2.02.02.02.01.9-2.02.01.9-2.11.6
Bone: endosteal estimation2.14.75.21.52.2-2.3-2.22.22.2-2.2-2.2-2.3-2.22.2-2.2-2.22.1-1.9
Bone: endosteal perimeter1.32.63.11.31.7-1.8-1.71.71.6-1.6-1.6-1.7-1.21.7-1.7-1.71.6-1.7
Epididymis fat weight3.47.911.32.12.7-2.7-3.02.82.9-2.9-3.0-2.9-3.42.9-2.9-2.72.9-2.0
Delta time in closed arm before/after self-admin1.31.24.81.40.7-0.7-1.31.31.1-1.1-1.1-1.0-2.21.0-0.9-0.70.7-0.2
Delta time in open arm before/after self-admin0.10.10.6-0.80.1-0.10.4-0.4-0.30.30.30.20.7-0.20.20.1-0.1-0.0
Diff in mean of infusions in LGA sessions0.91.06.42.50.3-0.4-1.11.10.8-0.8-0.8-0.8-0.60.8-0.7-0.70.7-0.8
Delay discount exponential model param0.10.11.3-1.1-0.1-0.10.4-0.3-0.30.30.20.20.2-0.20.20.2-0.10.3
Extinction: sum of active levers before priming5.45.46.2-1.4-2.32.42.3-2.4-2.42.42.42.42.4-2.42.42.3-2.52.1
Active lever presses in extinction session 60.30.30.7-0.9-0.60.50.5-0.5-0.50.50.50.50.4-0.50.50.5-0.40.4
Bone: final force1.62.62.91.01.5-1.6-1.71.71.7-1.7-1.7-1.7-1.51.7-1.7-1.71.7-1.6
Bone: final moment1.32.12.30.91.4-1.5-1.51.51.5-1.5-1.5-1.5-1.31.5-1.5-1.51.5-1.4
Food consumed during 24 hour testing period1.72.02.51.61.5-1.4-1.51.41.5-1.5-1.5-1.4-1.61.4-1.4-1.31.4-1.2
Glucose0.40.61.20.1-0.60.70.7-0.7-0.80.80.80.81.1-0.80.80.8-0.90.6
Heart weight0.00.00.4-0.7-0.0-0.10.0-0.10.0-0.0-0.1-0.1-0.10.1-0.1-0.10.20.1
Delay discount hyperbolic model param0.20.21.5-1.2-0.1-0.00.5-0.5-0.40.40.40.40.4-0.40.30.3-0.20.4
Intermittent access intake day 1-15 change3.02.95.82.41.2-1.4-1.81.71.7-1.7-1.7-1.7-1.01.7-1.7-1.81.8-2.0
Intermittent access intake escalation3.43.37.42.71.1-1.3-2.02.01.9-1.9-1.8-1.8-1.51.8-1.8-1.81.8-1.9
Intermittent access intake escalation 21.51.54.52.10.5-0.7-1.41.31.2-1.2-1.2-1.2-1.01.2-1.1-1.11.1-1.3
Intermitt. access day 1 inactive lever presses0.40.51.20.81.1-1.0-0.60.60.6-0.6-0.6-0.6-0.70.6-0.6-0.50.7-0.4
Intermitt. access day 15 inactive lever presses0.10.10.4-0.2-0.10.10.3-0.4-0.30.30.30.3-0.0-0.40.40.4-0.20.6
Intermitt. access escalation Index1.71.53.31.3-1.81.80.7-0.8-1.01.01.11.10.6-1.21.31.3-1.51.1
Intermittent access day 1 total infusions2.22.54.3-0.3-2.12.01.4-1.4-1.61.61.61.61.3-1.61.71.7-1.71.5
Intermittent access day 15 total infusions0.50.55.82.4-1.10.8-0.50.40.2-0.2-0.1-0.1-0.30.1-0.00.00.0-0.1
Intermittent access terminal intake (last 3 days)0.60.76.12.5-1.41.2-0.30.2-0.10.10.20.20.0-0.20.30.3-0.30.0
Intermittent access total infusions0.80.93.21.3-1.81.60.5-0.5-0.70.70.80.80.8-0.80.80.8-0.80.5
Intermittent access day 1 locomotion1.11.12.70.9-1.61.60.7-0.8-0.90.91.01.00.6-1.01.11.1-1.11.0
Intermittent access day 15 total locomotion0.30.32.91.7-0.50.3-0.40.30.3-0.3-0.2-0.2-0.40.2-0.1-0.10.3-0.1
Intermittent access total locomotion0.70.83.01.3-1.71.50.4-0.5-0.60.60.70.70.3-0.70.70.8-0.60.7
Intermittent access standard deviation0.20.22.51.6-0.40.2-0.30.30.1-0.2-0.1-0.10.20.1-0.1-0.20.2-0.5
Left kidney weight1.23.35.31.81.8-2.0-1.81.91.7-1.7-1.7-1.8-0.61.9-1.9-2.01.9-2.3
Right kidney weight0.92.43.11.41.7-1.7-1.61.61.5-1.5-1.5-1.6-0.81.6-1.6-1.61.7-1.8
Cocaine induced anxiety0.10.11.31.1-0.20.2-0.30.10.1-0.1-0.1-0.1-0.60.00.00.10.00.3
Post-drug Anxiety0.20.31.31.1-0.40.5-0.20.00.00.00.00.1-1.1-0.20.30.4-0.20.9
Baseline Anxiety0.60.61.0-0.6-0.70.70.8-0.8-0.80.80.80.80.5-0.80.90.9-0.91.0
Tail length0.92.84.41.91.4-1.6-1.71.71.6-1.6-1.6-1.6-0.91.7-1.7-1.81.6-2.1
Length with tail1.45.06.11.32.3-2.5-2.32.32.3-2.3-2.3-2.3-1.92.3-2.3-2.32.3-2.3
Length without tail0.81.82.40.21.5-1.5-1.31.31.4-1.3-1.4-1.4-1.51.4-1.4-1.31.4-1.0
Times rat made contact with spout2.52.93.7-1.2-1.91.91.7-1.8-1.71.71.71.70.9-1.81.81.8-1.81.9
Lifetime Intake1.41.65.21.0-2.32.00.9-0.8-1.11.11.21.21.1-1.21.21.2-1.20.9
Liver weight, left0.10.11.11.00.2-0.2-0.30.30.3-0.3-0.3-0.2-0.30.2-0.2-0.20.3-0.1
Liver weight, right1.52.44.00.72.0-1.8-1.51.61.6-1.5-1.6-1.6-1.51.6-1.6-1.51.5-1.3
Locomotor activity0.10.10.20.30.4-0.5-0.30.40.1-0.2-0.2-0.30.40.3-0.3-0.30.4-0.5
Locomotor testing distance2.54.27.9-0.8-2.22.02.0-1.9-2.32.22.22.12.8-2.02.12.0-2.11.5
Locomotor testing rearing3.75.77.3-1.3-2.62.42.4-2.4-2.52.52.52.52.7-2.42.42.4-2.42.1
Locomotion in novel chamber0.80.98.42.90.2-0.4-1.00.90.6-0.6-0.6-0.6-0.20.6-0.5-0.60.3-1.0
Locomotion in novel chamber post-restriction1.61.99.43.10.9-0.9-1.51.51.2-1.2-1.1-1.1-0.61.1-1.1-1.20.9-1.6
Fecal boli incidents, locomotor time 11.21.39.83.1-0.00.1-1.10.80.8-0.8-0.8-0.7-2.10.6-0.5-0.20.30.3
Change in fecal boli incidents, locomotor task0.30.31.71.2-0.20.00.10.0-0.20.20.20.21.3-0.10.1-0.0-0.2-0.6
Time >=10cm from walls, locomotor time 15.55.68.8-1.33.0-3.0-1.81.92.3-2.3-2.4-2.4-1.92.4-2.5-2.62.7-2.3
Bouts of movement, locomotor time 11.11.21.80.40.8-0.9-1.11.21.2-1.2-1.2-1.2-1.41.2-1.2-1.11.2-0.9
Total resting periods, locomotor time 11.01.12.40.90.6-0.6-1.11.21.1-1.1-1.1-1.1-1.61.0-1.0-1.01.0-0.7
Rest time, locomotor task time 10.40.42.21.4-0.20.1-0.70.50.5-0.5-0.5-0.4-1.50.4-0.3-0.20.30.3
Distance moved, locomotor task time 13.74.013.8-3.7-1.31.32.2-2.0-2.01.91.91.92.3-1.81.71.6-1.71.4
Vertical activity count, locomotor time 11.71.87.7-2.8-0.70.51.5-1.2-1.21.21.21.12.5-1.00.90.6-0.80.1
Time >=10cm from walls, locomotor time 21.61.73.2-1.51.6-1.8-0.70.81.1-1.1-1.2-1.2-0.51.3-1.4-1.51.6-1.3
Bouts of movement, locomotor time 20.30.33.1-1.80.1-0.20.10.10.2-0.2-0.3-0.3-0.30.3-0.3-0.30.5-0.0
Total resting periods, locomotor time 20.30.34.2-2.1-0.10.10.4-0.3-0.10.10.10.1-0.2-0.10.00.00.20.4
Rest time, locomotor task time 20.10.10.60.6-0.20.1-0.30.20.2-0.2-0.2-0.1-0.80.1-0.10.00.00.1
Distance moved, locomotor task time 20.30.34.2-2.1-0.10.10.4-0.3-0.20.20.20.10.3-0.10.10.10.00.2
Vertical activity count, locomotor time 20.40.44.0-2.0-0.1-0.10.4-0.2-0.10.10.10.01.20.1-0.2-0.40.3-0.6
Light reinforcement 11.12.02.7-1.1-1.31.21.6-1.6-1.51.51.51.51.0-1.51.51.5-1.31.6
Light reinforcement 20.00.00.30.5-0.0-0.10.00.00.00.0-0.0-0.0-0.2-0.00.00.10.10.2
Bone: marrow area2.14.55.01.42.2-2.2-2.22.22.2-2.2-2.2-2.2-2.22.2-2.2-2.12.1-1.9
Bone: maximum diameter0.40.71.40.61.0-1.0-0.80.90.7-0.7-0.7-0.8-0.10.8-0.8-0.90.8-1.2
Bone: maximum force2.03.53.91.31.8-1.9-1.92.01.9-1.9-1.9-1.9-1.62.0-2.0-1.92.0-1.9
Bone: maximum moment1.72.93.31.31.7-1.8-1.81.81.7-1.7-1.7-1.8-1.31.8-1.8-1.81.8-1.8
Mean time between licks in bursts0.10.20.50.7-0.30.40.3-0.3-0.40.40.40.40.6-0.40.40.4-0.50.2
Mean num. licks in bursts0.70.84.92.20.6-0.7-0.90.80.8-0.8-0.7-0.7-0.40.7-0.7-0.80.5-1.0
Cd content in liver3.64.04.51.21.8-1.9-2.12.12.1-2.1-2.1-2.1-1.82.1-2.1-2.12.1-2.0
Co content in liver1.31.63.20.21.2-1.3-1.21.31.2-1.3-1.3-1.3-0.31.3-1.4-1.51.4-1.8
Cu content in liver0.30.42.9-1.7-0.30.30.6-0.5-0.40.40.40.4-0.0-0.50.40.5-0.40.7
Fe content in liver3.03.64.9-1.4-2.22.21.9-1.9-1.91.91.91.91.2-1.91.92.0-1.92.1
K content in liver1.11.11.80.71.0-1.2-1.11.11.1-1.1-1.1-1.1-1.41.1-1.1-1.01.1-0.7
Mg content in liver0.30.30.50.70.4-0.6-0.50.50.5-0.5-0.5-0.5-0.60.5-0.5-0.50.5-0.4
Mn content in liver4.34.86.42.22.1-2.1-2.32.22.3-2.3-2.3-2.2-2.52.2-2.2-2.12.3-1.7
Na content in liver0.20.20.90.40.5-0.6-0.50.40.5-0.5-0.5-0.5-0.90.4-0.4-0.40.4-0.1
Rb content in liver0.00.00.20.4-0.40.1-0.10.10.1-0.1-0.1-0.1-0.20.1-0.1-0.10.10.0
Se content in liver1.51.82.20.01.3-1.4-1.41.41.4-1.4-1.4-1.4-1.51.4-1.4-1.31.5-1.1
Sr content in liver0.10.10.60.8-0.1-0.0-0.30.40.2-0.3-0.2-0.20.30.3-0.3-0.40.3-0.7
Zn content in liver1.51.73.41.51.2-1.2-1.31.41.2-1.3-1.2-1.2-0.31.3-1.3-1.41.3-1.9
Bone: minimum diameter1.63.03.40.91.7-1.8-1.81.81.8-1.8-1.8-1.8-1.81.8-1.8-1.81.8-1.5
Time in familiar zone, hab. session 11.00.91.9-1.2-0.91.00.9-1.0-0.80.80.80.9-0.0-0.90.91.0-1.01.4
Time in novel zone, hab. session 10.20.21.80.3-0.30.10.2-0.1-0.30.30.40.31.4-0.20.20.00.0-0.5
Total zone transitions, hab. session 11.21.68.20.4-0.90.91.2-1.0-1.41.41.41.22.9-1.11.10.9-1.10.1
Total locomotion distance, hab. session 10.20.31.9-0.60.10.10.4-0.3-0.50.50.50.41.4-0.30.30.2-0.4-0.3
Locomotion velocity, hab. session 10.20.32.1-0.50.10.10.5-0.4-0.60.60.60.51.5-0.40.40.2-0.5-0.2
Time in familiar zone, hab. session 21.61.62.3-1.5-1.11.21.3-1.3-1.21.21.21.30.9-1.31.31.3-1.31.3
Time in novel zone, hab. session 20.00.00.50.7-0.30.1-0.00.0-0.10.00.10.00.1-0.00.10.10.0-0.0
Total zone transitions, hab. session 21.31.75.0-0.6-1.11.21.3-1.2-1.51.51.51.32.2-1.21.21.1-1.30.7
Total locomotion distance, hab. session 20.91.12.3-1.4-0.60.81.1-1.0-1.21.21.21.11.5-1.01.00.9-1.10.7
Locomotion velocity, hab. session 20.60.81.9-1.1-0.40.70.9-0.8-1.01.01.00.91.4-0.80.80.8-0.90.5
Novel to familiar place preference ratio3.94.012.33.51.4-1.7-2.02.11.9-1.9-1.8-1.9-0.91.9-1.9-1.91.8-2.3
Novelty place preference3.93.912.23.51.4-1.7-2.02.01.9-1.9-1.8-1.8-1.01.9-1.9-1.91.8-2.2
Time in novel zone, NPP test3.03.110.73.31.2-1.5-1.81.81.6-1.6-1.6-1.6-0.71.6-1.6-1.71.6-2.0
Total zone transitions, NPP test3.55.011.8-1.1-1.72.02.3-2.2-2.52.52.52.33.4-2.22.22.0-2.31.4
Total locomotion distance, NPP test1.52.05.0-1.1-0.91.31.5-1.3-1.61.61.61.42.2-1.41.41.3-1.50.8
Locomotion velocity, NPP test0.70.92.7-0.9-0.40.81.0-0.9-1.11.11.11.01.6-0.90.90.8-1.00.5
Intraocular pressure0.10.11.5-1.20.00.20.2-0.2-0.10.10.10.2-0.3-0.20.20.2-0.10.3
Delta distance traveled before/after self-admin0.10.20.6-0.80.5-0.5-0.20.10.3-0.3-0.4-0.4-0.60.3-0.3-0.30.40.0
Delta ambulatory time before/after self-admin0.70.81.9-0.20.8-0.8-0.80.71.0-0.9-1.0-0.9-1.40.9-0.9-0.80.9-0.4
Parametrial fat weight0.00.10.6-0.0-0.20.1-0.20.10.2-0.2-0.2-0.2-0.80.1-0.1-0.00.30.3
Pavlov. Cond. lever latency0.10.10.4-0.5-0.50.40.3-0.3-0.30.30.30.3-0.3-0.30.40.4-0.30.6
Pavlov. Cond. magazine entry latency0.81.01.2-0.6-1.01.11.1-1.1-1.01.01.01.10.7-1.11.11.1-1.11.1
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.20.20.1-0.1-0.10.10.10.1-0.0-0.10.10.1-0.10.1
Pavlov. Cond. index score0.40.50.6-0.5-0.70.70.8-0.7-0.70.70.70.70.6-0.70.70.7-0.70.7
Pavlov. Cond. latency score0.00.00.10.3-0.10.20.2-0.1-0.10.10.10.10.3-0.10.10.1-0.1-0.0
Pavlov. Cond. lever contacts0.10.10.5-0.40.00.10.2-0.2-0.20.20.20.20.7-0.10.10.0-0.1-0.2
Pavlov. Cond. magazine entry number0.60.81.31.00.9-0.9-0.90.90.8-0.8-0.8-0.9-0.30.9-0.9-0.90.9-1.1
Pavlov. Cond. intertrial magazine entries3.84.65.2-2.2-1.81.92.2-2.2-2.32.32.32.22.2-2.12.22.1-2.32.1
Pavlov. Cond. lever-magazine prob. diff.1.01.21.4-1.0-1.11.21.2-1.2-1.11.11.11.10.8-1.11.11.1-1.11.2
Pavlov. Cond. response bias1.31.63.0-1.7-1.11.21.4-1.3-1.21.21.21.21.0-1.21.21.2-1.21.3
Pavlov. Cond. lever latency0.20.23.1-1.80.1-0.10.2-0.2-0.10.10.10.0-0.5-0.00.00.10.00.5
Pavlov. Cond. magazine entry latency0.40.41.2-1.1-0.40.50.7-0.7-0.60.60.60.60.4-0.70.60.6-0.60.7
Pavlov. Cond. change in total contacts0.70.92.11.40.8-0.8-1.00.91.0-1.0-1.0-0.9-1.00.9-0.9-0.90.8-0.8
Pavlov. Cond. index score0.10.10.50.70.3-0.3-0.30.30.3-0.3-0.3-0.3-0.10.2-0.3-0.30.3-0.4
Pavlov. Cond. latency score0.30.40.60.80.7-0.7-0.60.60.7-0.7-0.6-0.6-0.40.6-0.6-0.70.6-0.7
Pavlov. Cond. lever contacts0.20.33.11.70.1-0.1-0.40.40.2-0.3-0.2-0.20.40.2-0.2-0.30.2-0.7
Pavlov. Cond. magazine entry number0.20.20.50.60.4-0.4-0.50.50.5-0.5-0.5-0.5-0.70.5-0.5-0.40.4-0.3
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.0-0.30.20.1-0.2-0.10.10.10.1-0.1-0.10.20.2-0.20.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.70.3-0.3-0.30.30.3-0.3-0.3-0.2-0.20.2-0.3-0.30.2-0.4
Pavlov. Cond. response bias0.10.22.11.5-0.10.1-0.10.1-0.00.00.00.00.6-0.00.0-0.1-0.1-0.4
Time in closed arm before self-admin1.71.917.4-4.2-0.00.01.4-1.3-0.90.90.90.72.0-0.70.50.3-0.3-0.0
Time in closed arm after self-admin0.40.55.8-2.40.4-0.30.1-0.00.1-0.1-0.2-0.2-0.60.2-0.2-0.10.20.3
Time in open arm before self-admin4.65.030.05.51.1-1.1-2.52.32.0-2.0-1.9-1.8-2.41.7-1.6-1.41.3-1.3
Time in open arm after self-admin0.50.54.82.20.5-0.5-0.50.40.3-0.3-0.3-0.30.50.3-0.3-0.40.3-0.8
Bone: periosteal estimation1.93.94.41.42.0-2.1-2.12.12.0-2.0-2.0-2.1-1.72.1-2.1-2.12.0-2.0
Bone: periosteal perimeter2.54.15.41.72.1-2.1-2.12.22.0-2.0-2.0-2.1-1.32.1-2.1-2.22.0-2.3
Bone: post-yield work1.62.22.81.71.5-1.5-1.51.61.5-1.5-1.5-1.5-0.91.5-1.5-1.61.5-1.6
Progressive ratio test 1 active lever presses2.72.96.00.4-2.42.41.4-1.4-1.61.61.71.71.2-1.71.81.8-1.81.7
Progressive ratio test 1 breakpoint2.22.35.00.5-2.22.11.2-1.2-1.41.41.51.51.0-1.51.61.6-1.61.5
Progressive ratio test 1 inactive lever presses0.70.71.6-0.2-1.01.00.8-0.9-0.80.80.80.80.1-0.90.91.0-0.71.3
Progressive ratio test 2 active lever presses1.01.13.81.0-2.01.70.6-0.6-0.80.80.80.90.1-0.91.01.1-0.91.1
Progressive ratio test 2 breakpoint0.80.93.00.6-1.71.50.7-0.7-0.80.80.80.90.3-0.90.91.0-0.81.1
Progressive ratio test 2 inactive lever presses0.10.11.51.2-0.40.3-0.30.30.2-0.2-0.2-0.1-0.20.1-0.1-0.10.2-0.2
Incentive Sensitization - Responses0.30.30.90.5-0.90.80.4-0.4-0.40.40.40.50.0-0.50.50.6-0.40.7
Incentive Sensitization - Breakpoint0.30.41.00.3-1.00.80.5-0.5-0.50.50.50.50.1-0.60.60.6-0.50.8
Sum of active levers in priming session hrs 5-62.01.93.40.3-1.91.81.2-1.3-1.31.31.31.40.8-1.41.41.5-1.31.7
Progressive ratio0.30.42.01.40.4-0.3-0.70.50.5-0.5-0.5-0.5-0.80.4-0.4-0.40.3-0.3
Food seeking constrained by brief footshock1.31.62.40.5-1.61.41.1-1.1-1.31.31.31.31.1-1.31.41.4-1.41.2
Seeking ratio, punishment vs. effort0.70.91.4-0.6-0.90.91.0-0.8-1.01.01.01.01.2-1.00.90.9-0.90.7
Retroperitoneal fat weight1.75.67.10.92.4-2.6-2.42.32.4-2.4-2.5-2.5-2.22.5-2.5-2.42.7-2.1
Reaction time number correct2.13.16.1-2.5-1.61.51.9-1.9-1.81.81.71.71.6-1.71.61.6-1.51.7
Reaction time mean minus median0.91.21.61.00.9-1.0-1.21.21.1-1.1-1.1-1.1-0.81.1-1.1-1.10.9-1.3
Reaction time mean minus median AUC1.62.14.4-0.21.3-1.3-1.51.51.6-1.6-1.6-1.5-2.11.5-1.5-1.41.3-1.0
Reaction time num false alarms1.92.54.3-2.1-1.11.11.8-1.8-1.71.61.61.62.1-1.61.51.4-1.31.2
Reaction time num false alarms AUC1.92.64.5-1.8-1.31.31.9-1.9-1.71.71.71.72.1-1.61.61.4-1.41.1
Reaction time trials correct on left2.13.16.1-2.5-1.61.51.9-1.9-1.81.81.71.71.6-1.71.61.6-1.51.7
Reaction time trials on left2.13.05.9-2.4-1.61.51.9-1.9-1.71.71.71.71.5-1.71.61.6-1.51.7
Reaction time mean1.11.62.21.50.9-1.1-1.41.41.3-1.3-1.3-1.3-1.31.3-1.2-1.21.1-1.2
Reaction time mean AUC1.52.02.61.21.1-1.2-1.51.51.5-1.5-1.5-1.5-1.61.5-1.4-1.41.3-1.2
Median of all reaction times0.60.81.71.30.6-0.7-1.01.00.9-0.9-0.9-0.9-1.10.9-0.9-0.80.7-0.7
Reaction time omissions0.40.50.6-0.20.5-0.7-0.70.80.8-0.8-0.7-0.8-0.70.8-0.8-0.80.7-0.8
Reaction time false alarm rate0.10.10.8-0.30.1-0.00.4-0.3-0.30.30.30.30.9-0.20.20.1-0.0-0.2
Reaction time premature initiation rate1.11.52.41.1-1.41.51.1-0.8-1.21.21.31.31.5-1.31.31.2-1.40.7
Reaction time premature initiations2.53.64.5-0.1-2.12.11.9-1.7-1.91.92.02.02.1-2.02.02.0-2.11.5
Std. dev. reaction times1.01.41.81.11.0-1.0-1.31.31.2-1.3-1.2-1.2-1.01.2-1.2-1.21.0-1.3
Reaction time trials completed2.13.05.9-2.4-1.61.51.9-1.9-1.71.71.71.71.5-1.71.61.6-1.51.7
Reaction time trials AUC2.63.75.9-2.4-1.81.82.1-2.1-1.91.91.91.91.6-1.91.81.8-1.71.9
Run reversals in cocaine runway, females0.20.21.8-1.40.1-0.6-0.00.10.3-0.3-0.3-0.3-0.10.3-0.4-0.40.6-0.3
Run reversals in cocaine runway, males0.40.31.5-1.21.1-0.7-0.20.30.4-0.4-0.4-0.4-0.40.4-0.5-0.40.5-0.3
Latency to leave start box in cocaine runway0.70.81.6-1.3-0.50.70.9-0.9-0.90.90.90.90.8-0.90.80.8-0.90.8
Latency to leave start box in cocaine runway, F0.30.41.9-1.4-0.00.20.7-0.6-0.60.60.50.50.7-0.50.50.4-0.50.4
Latency to leave start box in cocaine runway, M1.71.61.9-1.4-1.21.21.4-1.3-1.31.31.31.31.3-1.31.31.2-1.21.2
Std. dev. time between licks in bursts0.50.61.00.71.0-0.8-0.80.80.8-0.8-0.8-0.8-0.60.9-0.8-0.80.8-0.7
Total sessions with >9 infusions1.51.73.80.4-1.91.81.0-1.1-1.21.21.31.31.0-1.31.31.4-1.41.2
Short access day 1 total inactive lever presses2.02.22.8-0.6-1.41.41.5-1.6-1.61.61.61.61.2-1.61.61.6-1.51.7
Short access day 10 total inactive lever presses0.60.71.3-0.21.1-1.1-0.70.70.8-0.8-0.8-0.8-0.50.8-0.9-0.91.0-0.9
Short access day 1 total infusions0.70.74.00.4-2.01.70.4-0.5-0.60.60.60.60.1-0.60.70.7-0.60.8
Short access day 10 total infusions0.80.92.81.3-1.71.50.5-0.4-0.70.70.80.80.7-0.80.80.8-0.80.6
Short access total infusions1.92.16.00.4-2.52.21.1-1.1-1.31.31.41.41.2-1.41.41.4-1.41.2
Short access day 1 locomotion0.10.10.4-0.2-0.60.50.4-0.5-0.30.30.30.3-0.0-0.30.30.4-0.10.6
Short access day 10 total locomotion0.40.51.71.2-1.31.10.3-0.4-0.50.50.50.50.4-0.50.60.6-0.50.5
Short access total locomotion0.70.72.41.3-1.61.40.4-0.5-0.60.60.70.70.2-0.70.80.8-0.70.8
One hour access (0.3 mA shock)0.60.72.41.5-1.61.30.3-0.3-0.50.50.60.60.7-0.60.60.6-0.60.2
Compulsive drug intake0.50.51.31.10.9-0.8-0.80.80.7-0.7-0.7-0.7-0.50.7-0.6-0.60.5-0.7
One hour access (shock baseline)0.70.93.30.4-1.81.50.7-0.7-0.80.80.80.80.7-0.80.80.8-0.80.7
Social response proportion1.51.62.81.70.9-1.0-1.31.31.3-1.3-1.3-1.3-1.31.2-1.2-1.21.2-1.3
Social responses0.10.20.30.4-0.50.50.4-0.3-0.40.40.40.40.5-0.40.40.4-0.40.2
Social time0.30.40.9-0.20.9-0.9-0.50.60.6-0.6-0.6-0.60.00.7-0.7-0.80.6-0.9
Soleus weight0.41.11.6-1.3-0.91.01.0-1.1-1.11.11.01.00.8-1.01.01.1-1.01.2
Bone: stiffness7.211.413.62.53.3-3.5-3.53.53.5-3.5-3.5-3.5-3.13.5-3.5-3.53.7-3.2
Tibialis anterior weight0.10.20.6-0.20.8-0.7-0.40.40.4-0.4-0.4-0.5-0.10.5-0.5-0.50.6-0.5
Time to tail flick, vehicle, before self-admin0.50.56.9-2.60.0-0.10.5-0.5-0.20.20.10.1-0.3-0.10.10.10.20.6
Time to tail flick, vehicle, after self-admin0.30.32.4-1.6-0.30.30.1-0.00.00.0-0.0-0.0-1.0-0.00.10.2-0.00.7
Time to tail flick, test, before self-admin3.43.319.2-4.4-0.80.82.0-1.8-1.61.61.61.52.2-1.41.31.1-1.21.0
Time to tail flick, test, after self-admin0.80.85.2-2.3-0.50.50.9-0.9-0.80.80.70.70.9-0.70.60.6-0.60.5
Delta time to tail flick, vehicle, before/after SA0.50.51.91.40.1-0.2-0.80.90.7-0.7-0.6-0.6-0.80.6-0.6-0.50.5-0.5
Delta time to tail flick, test, before/after SA1.00.92.41.50.5-0.5-1.10.91.0-1.0-1.0-0.9-1.30.9-0.8-0.80.8-0.7
Tibia length0.10.31.40.50.3-0.3-0.60.50.6-0.6-0.6-0.5-1.20.5-0.5-0.40.5-0.2
Ambulatory time before self-admin0.40.44.00.90.10.10.3-0.1-0.40.30.40.32.0-0.30.2-0.1-0.3-1.0
Ambulatory time after self-admin0.40.42.1-0.20.7-0.7-0.10.30.2-0.3-0.2-0.31.40.4-0.5-0.70.5-1.4
Bone: tissue strength0.30.30.40.50.6-0.6-0.60.60.6-0.6-0.6-0.6-0.60.6-0.6-0.60.6-0.5
Total heroin consumption1.61.93.61.4-1.61.61.1-1.1-1.31.31.41.41.9-1.41.41.3-1.40.8
Bone: trabecular number0.00.00.2-0.3-0.30.30.1-0.1-0.10.10.10.1-0.3-0.10.10.20.20.4
Bone: trabecular spacing0.00.00.10.00.2-0.2-0.10.10.0-0.0-0.0-0.10.10.1-0.1-0.1-0.3-0.2
Bone: trabecular thickness0.10.20.4-0.3-0.60.50.4-0.4-0.30.40.30.4-0.0-0.40.40.4-0.20.6
Bone: trabecular tissue density0.00.00.00.2-0.10.1-0.10.10.1-0.1-0.1-0.1-0.10.1-0.1-0.10.0-0.1
Water consumed over 24 hours2.32.84.9-2.2-1.61.71.7-1.8-1.51.61.51.60.5-1.71.71.8-1.62.0
Number of responses in last shaping day0.90.91.21.10.9-0.9-1.11.11.0-1.0-1.0-1.0-0.91.0-0.9-0.91.0-0.9