Hub : Genes

Eif5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC mRNA stability Eif5 0.16 0.16 1.8e-04 0.08 0.08 0.02 0.08 2.1e-04 3.0e-04 4.8e-02 2.2e-04
2 Brain mRNA stability Eif5 0.45 0.2 0.0e+00 0.26 0.27 0.26 0.27 2.9e-24 2.1e-25 3.4e-24 4.4e-25
3 BLA mRNA stability Eif5 0.29 0.15 5.6e-16 0.28 0.29 0.28 0.29 2.3e-15 1.7e-15 1.9e-15 8.5e-16
4 PL mRNA stability Eif5 0.19 0.1 0.0e+00 0.27 0.28 0.28 0.28 2.0e-29 1.5e-30 2.6e-30 2.3e-30
5 NAcc mRNA stability Eif5 0.11 0.07 0.0e+00 0.15 0.15 0.15 0.15 1.1e-21 2.0e-22 5.4e-22 1.7e-21
6 pVTA mRNA stability Eif5 0.21 0.16 1.8e-14 0.18 0.19 0.18 0.18 2.3e-14 6.8e-15 4.4e-14 1.9e-14
7 IL mRNA stability Eif5 0.19 0.17 2.2e-03 0.11 0.11 0.11 0.12 1.1e-03 1.3e-03 1.2e-03 1.1e-03
8 OFC mRNA stability Eif5 0.34 0.23 5.1e-05 0.14 0.12 0.13 0.13 3.9e-04 7.0e-04 4.6e-04 6.2e-04
9 Liver gene expression Eif5 0.09 0.06 7.5e-11 0.08 0.08 0.07 0.08 2.5e-09 2.7e-09 1.4e-08 3.3e-09
10 Liver mRNA stability Eif5 0.24 0.17 0.0e+00 0.17 0.17 0.18 0.18 1.1e-18 5.0e-19 1.0e-19 2.5e-19
11 LHb mRNA stability Eif5 0.22 0.16 2.0e-04 0.16 0.16 0.15 0.16 1.5e-04 1.2e-04 2.6e-04 1.6e-04
12 Adipose mRNA stability Eif5 0.49 0.28 0.0e+00 0.3 0.3 0.3 0.3 8.7e-34 6.9e-34 1.1e-33 9.2e-34
13 Adipose gene expression Eif5 0.06 0.05 5.0e-07 0.05 0.05 0.05 0.05 2.1e-06 3.8e-06 4.7e-06 3.9e-06
14 RMTg isoform ratio XM_039111602.2 0.86 0.07 8.5e-04 0 -0.01 0.06 -0 2.4e-01 5.7e-01 1.3e-02 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.3-0.4-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.4-0.1
Area under the delay curve0.50.66.1-0.5-0.4-0.2-0.3-0.4-0.2-0.7-0.7-0.3-0.7-0.3-0.20.22.5
BMI with tail3.913.517.0-3.6-4.1-3.8-3.8-3.8-3.6-3.5-3.5-3.7-4.1-3.7-3.6-2.63.9
BMI without tail2.98.711.2-3.0-3.3-3.1-3.0-3.0-2.9-3.0-3.0-2.9-3.3-2.9-2.9-2.02.7
Body weight0.10.31.40.50.10.40.30.30.50.60.60.40.00.40.51.21.1
Weight adjusted by age0.10.10.80.20.10.10.20.10.20.20.20.2-0.00.20.20.40.9
Bone surface0.10.20.3-0.5-0.6-0.5-0.4-0.4-0.4-0.4-0.4-0.3-0.5-0.3-0.5-0.2-0.1
Bone volume0.10.20.3-0.6-0.6-0.5-0.5-0.4-0.5-0.5-0.5-0.4-0.5-0.4-0.6-0.4-0.3
Breakpoint value in progressive ratio session0.00.10.2-0.10.20.10.20.20.1-0.1-0.10.20.40.20.1-0.3-0.4
Number of licking bursts0.10.10.20.30.10.20.20.30.30.40.40.30.10.40.30.50.0
Context. condit. distance diff. score1.61.92.41.41.51.41.41.41.41.51.51.41.61.41.51.0-1.1
Locomotion velocity, session 10.30.30.50.40.40.40.50.50.50.70.70.70.50.60.50.6-0.7
Locomotion distance, session 10.30.40.7-0.8-0.7-0.8-0.7-0.6-0.7-0.4-0.4-0.5-0.4-0.6-0.7-0.90.2
Locomotion velocity, session 20.00.00.30.20.20.0-0.1-0.1-0.10.10.10.00.3-0.3-0.0-0.60.3
Locomotion distance, session 20.30.40.6-0.8-0.7-0.7-0.7-0.6-0.7-0.7-0.7-0.7-0.6-0.6-0.7-0.80.4
Locomotion velocity, session 30.20.20.6-0.3-0.3-0.4-0.4-0.4-0.5-0.4-0.4-0.4-0.2-0.5-0.4-0.80.3
Locomotion distance, session 30.00.00.10.20.10.10.10.10.10.30.30.10.20.20.1-0.1-0.3
Stereotopy head waving bouts, day 30.10.20.30.30.40.40.40.40.40.40.40.50.50.40.40.3-0.1
Stereotopy head waving duration, day 30.30.30.50.40.70.60.60.60.60.60.60.70.70.50.60.4-0.4
Locomotion velocity, session 70.20.30.9-0.3-0.2-0.4-0.5-0.5-0.6-0.4-0.4-0.5-0.2-0.7-0.5-1.00.5
Locomotion distance, session 70.70.91.5-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.8-1.0-1.0-1.20.9
Stereotopy head waving bouts, day 70.60.70.80.90.90.90.80.80.80.90.90.80.70.80.80.8-0.8
Stereotopy head waving duration, day 70.30.40.40.70.60.70.60.60.60.70.70.60.60.50.60.6-0.6
Locomotion velocity, session 80.20.20.40.50.60.50.40.40.40.50.50.40.60.30.50.0-0.0
Locomotion distance, session 80.00.10.3-0.4-0.2-0.2-0.2-0.2-0.3-0.2-0.2-0.3-0.1-0.2-0.2-0.60.0
Degree of sensitization distance0.10.10.3-0.1-0.2-0.2-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.30.6
Degree of sensitization stereotypy0.20.30.40.60.50.50.50.50.50.60.60.50.40.50.40.5-0.6
Conditioned locomotion1.11.31.91.21.31.21.21.11.11.21.21.21.41.11.20.7-0.2
Cocaine response after cond. corrected0.50.60.8-0.8-0.8-0.8-0.7-0.7-0.7-0.8-0.8-0.8-0.9-0.7-0.8-0.60.7
Cocaine response after cond. not corrected1.82.12.5-1.5-1.5-1.5-1.5-1.5-1.4-1.5-1.5-1.6-1.6-1.4-1.5-1.31.0
Cocaine response before conditioning2.32.73.4-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.8-1.7-1.8-1.7-1.50.6
Saline control response0.10.20.3-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.4-0.4-0.5-0.50.1
Bone: connectivity density0.00.00.00.10.10.10.10.10.10.00.00.00.00.10.00.1-0.2
Bone: cortical apparent density8.111.112.63.53.53.53.43.43.43.53.53.43.53.33.42.9-2.1
Bone: cortical area0.50.71.30.70.70.70.91.00.90.80.80.90.71.10.80.9-0.9
Bone: cortical porosity0.00.10.20.10.30.20.10.10.10.20.20.20.40.10.2-0.3-0.4
Bone: cortical porosity0.20.20.7-0.5-0.3-0.5-0.4-0.4-0.5-0.4-0.4-0.4-0.2-0.4-0.5-0.8-0.2
Bone: cortical thickness0.61.01.60.91.00.91.11.11.00.90.91.01.11.20.80.5-1.3
Bone: cortical thickness0.70.91.10.90.90.91.01.00.91.01.00.91.01.10.90.6-0.8
Bone: cortical tissue density8.010.912.33.53.53.53.43.33.43.53.53.33.53.23.42.9-2.1
Condit. Reinf. active minus inactive responses0.60.70.9-0.9-0.9-0.8-0.8-0.8-0.8-0.9-0.9-0.9-0.9-0.8-0.8-0.80.3
Condit. Reinf. active-inactive response ratio2.62.83.3-1.8-1.7-1.7-1.7-1.7-1.7-1.8-1.8-1.8-1.7-1.6-1.7-1.60.7
Condit. Reinf. active responses0.20.30.4-0.5-0.5-0.4-0.5-0.5-0.5-0.6-0.6-0.7-0.5-0.5-0.6-0.60.1
Condit. Reinf. inactive responses1.72.12.71.61.51.51.51.51.51.51.51.51.51.51.51.4-0.8
Incentive salience index mean0.50.60.7-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.70.3
Condit. Reinf. lever presses0.10.10.2-0.4-0.4-0.4-0.4-0.5-0.4-0.3-0.3-0.3-0.3-0.5-0.4-0.40.3
Condit. Reinf. active minus inactive responses0.20.30.40.60.50.60.60.50.60.60.60.50.60.50.50.4-0.2
Condit. Reinf. active-inactive response ratio0.30.30.40.60.60.60.60.60.60.60.60.50.60.60.60.5-0.4
Condit. Reinf. active responses0.00.00.2-0.1-0.1-0.1-0.2-0.2-0.2-0.1-0.1-0.3-0.1-0.3-0.2-0.4-0.0
Condit. Reinf. inactive responses0.70.91.1-0.9-0.9-1.0-1.0-1.0-1.0-0.8-0.8-1.0-0.9-1.0-1.0-1.00.2
Condit. Reinf. lever presses1.62.22.6-1.6-1.5-1.6-1.6-1.6-1.6-1.4-1.4-1.6-1.4-1.6-1.5-1.50.3
Condit. Reinf. lever reinforcers received0.00.00.1-0.1-0.1-0.1-0.2-0.2-0.2-0.1-0.1-0.3-0.2-0.3-0.2-0.4-0.1
Conditioned reinforcement - actives0.50.91.71.01.10.90.90.90.81.01.00.81.00.80.90.7-1.3
Conditioned reinforcement - inactives0.20.42.10.50.60.40.40.40.30.60.60.40.60.30.30.2-1.4
Conditioned locomotion0.40.61.5-0.8-0.6-0.7-0.8-0.7-0.8-0.7-0.7-0.8-0.4-0.8-0.8-1.2-0.1
Patch foraging indifference point 0 sec2.64.85.92.32.42.42.32.22.32.12.12.22.12.12.22.3-1.7
Patch foraging indifference point AUC1.72.53.11.81.71.61.71.61.71.51.51.61.71.61.71.3-0.2
Delay disc. indifference point, 0s delay0.20.20.60.20.50.60.50.40.50.30.30.50.40.40.50.60.7
Delay disc. indifference point, 16s delay0.30.44.1-0.4-0.3-0.2-0.3-0.3-0.2-0.3-0.3-0.1-0.3-0.3-0.10.12.0
Delay disc. indifference point, 2s delay0.20.20.6-0.7-0.3-0.2-0.2-0.2-0.2-0.8-0.8-0.2-0.5-0.2-0.2-0.00.5
Delay disc. indifference point, 24s delay0.40.42.9-0.5-0.6-0.4-0.3-0.3-0.2-0.7-0.7-0.3-0.8-0.2-0.20.41.7
Delay disc. indifference point, 4s delay0.40.43.80.20.30.50.40.40.50.10.10.40.10.40.60.81.9
Delay disc. indifference point, 8s delay0.70.98.0-0.6-0.6-0.3-0.5-0.6-0.4-0.8-0.8-0.4-0.9-0.6-0.40.02.8
Indifference point function ln k0.40.61.40.70.70.80.70.70.70.80.80.80.50.80.61.0-1.2
Indifference point function log k0.40.61.40.70.70.80.70.70.70.80.80.80.50.80.61.0-1.2
Patch foraging total patch changes 0 sec2.85.36.62.52.52.62.42.32.42.22.22.32.22.22.32.3-1.7
Patch foraging total patch changes 12 sec3.54.65.72.42.42.42.22.22.22.12.12.02.22.02.22.0-1.4
Patch foraging total patch changes 18 sec1.31.93.51.51.71.61.41.31.31.41.41.41.91.11.50.7-0.6
Patch foraging total patch changes 24 sec0.10.20.30.50.50.60.40.40.50.40.40.30.30.40.40.50.1
Patch foraging total patch changes 6 sec1.72.53.51.91.71.91.71.61.81.41.41.51.31.61.71.9-0.3
Patch foraging time to switch 0 sec7.515.417.9-4.2-4.1-4.2-4.1-4.1-4.0-3.9-3.9-3.9-3.9-4.0-3.9-3.62.9
Patch foraging water rate 0 sec12.927.232.05.65.65.75.55.45.55.25.25.35.25.35.35.0-2.8
Patch foraging water rate 12 sec6.613.816.13.93.73.93.83.83.93.83.83.83.53.93.84.0-1.7
Patch foraging water rate 18 sec4.36.68.22.92.52.82.72.72.72.62.62.42.22.72.52.9-1.9
Patch foraging water rate 24 sec3.54.96.02.42.22.32.32.42.42.12.12.22.02.42.22.4-1.2
Patch foraging water rate 6 sec4.16.07.42.62.72.72.62.62.52.42.42.52.62.52.42.0-1.4
Seeking ratio, delayed vs. immediate footshock0.20.20.50.20.30.30.50.50.50.30.30.70.50.50.50.7-0.2
Distance traveled before self-admin0.40.52.2-0.3-0.7-0.5-0.7-0.8-0.7-0.3-0.3-0.5-0.8-0.8-0.7-0.51.5
Distance traveled after self-admin0.10.10.30.50.30.30.30.30.30.50.50.40.30.30.30.20.6
Extensor digitorum longus weight5.220.522.64.74.54.64.74.74.74.74.74.84.54.74.74.6-2.4
Bone: elastic displacement0.50.50.70.70.70.70.80.80.80.80.80.80.80.80.70.4-0.6
Bone: elastic work0.20.20.40.30.40.40.50.60.50.50.50.50.50.60.40.2-0.6
Bone: endosteal estimation0.30.71.2-1.1-1.1-1.0-0.9-0.9-0.8-0.8-0.8-0.7-1.0-0.7-0.7-0.21.0
Bone: endosteal perimeter0.10.20.4-0.6-0.6-0.5-0.3-0.3-0.2-0.4-0.4-0.2-0.6-0.1-0.20.50.4
Epididymis fat weight2.79.210.7-3.0-3.2-3.1-3.1-3.1-3.0-2.9-2.9-3.1-3.3-3.1-3.0-2.43.1
Delta time in closed arm before/after self-admin0.00.00.1-0.2-0.2-0.1-0.2-0.2-0.2-0.1-0.1-0.2-0.2-0.2-0.2-0.20.1
Delta time in open arm before/after self-admin0.80.81.01.00.80.80.90.80.91.01.01.00.80.91.01.00.5
Diff in mean of infusions in LGA sessions0.00.10.4-0.00.20.10.00.0-0.0-0.2-0.2-0.20.1-0.0-0.1-0.5-0.6
Delay discount exponential model param0.60.66.40.50.50.20.30.40.20.70.70.30.70.30.2-0.2-2.5
Extinction: sum of active levers before priming0.30.41.1-0.6-0.5-0.6-0.6-0.5-0.6-0.7-0.7-0.5-0.3-0.6-0.6-1.00.3
Active lever presses in extinction session 61.21.21.71.11.31.21.21.21.20.90.91.21.31.21.10.8-0.8
Bone: final force0.10.20.40.20.30.30.50.50.40.40.40.50.40.60.50.5-0.6
Bone: final moment0.10.20.50.20.30.30.50.50.40.50.50.50.40.70.50.5-0.7
Food consumed during 24 hour testing period0.10.10.10.20.20.30.30.30.30.20.20.40.30.40.30.3-0.3
Glucose0.81.21.61.21.21.21.11.11.11.31.31.01.11.11.00.9-1.1
Heart weight0.71.01.71.31.11.11.01.01.01.21.20.91.00.90.90.7-0.5
Delay discount hyperbolic model param0.50.55.30.50.40.10.30.30.10.60.60.20.60.20.1-0.3-2.3
Intermittent access intake day 1-15 change1.43.05.7-1.8-1.6-1.8-1.8-1.7-1.9-1.8-1.8-1.7-1.3-1.8-1.8-2.40.1
Intermittent access intake escalation1.42.85.9-1.7-1.5-1.7-1.7-1.7-1.8-1.7-1.7-1.6-1.3-1.7-1.8-2.4-0.0
Intermittent access intake escalation 20.70.82.0-0.9-0.8-0.9-0.9-0.8-1.0-0.7-0.7-0.8-0.6-0.9-1.0-1.4-0.5
Intermitt. access day 1 inactive lever presses0.20.72.30.80.80.80.80.80.70.90.90.80.70.70.70.6-1.5
Intermitt. access day 15 inactive lever presses0.91.93.71.61.41.31.31.31.21.51.51.21.21.21.31.2-1.9
Intermitt. access escalation Index0.30.41.20.50.50.70.70.60.8-0.1-0.10.60.30.70.71.10.6
Intermittent access day 1 total infusions0.30.50.9-0.7-0.7-0.6-0.7-0.7-0.6-0.7-0.7-0.7-0.8-0.7-0.6-0.41.0
Intermittent access day 15 total infusions1.32.03.0-1.4-1.3-1.4-1.4-1.4-1.4-1.7-1.7-1.4-1.2-1.4-1.4-1.60.8
Intermittent access terminal intake (last 3 days)1.82.43.1-1.4-1.4-1.5-1.6-1.6-1.6-1.7-1.7-1.6-1.4-1.7-1.6-1.80.7
Intermittent access total infusions0.91.11.6-0.9-0.9-0.9-1.0-1.0-1.0-1.3-1.3-1.1-1.0-1.1-1.0-1.10.7
Intermittent access day 1 locomotion1.72.12.6-1.6-1.5-1.5-1.5-1.5-1.6-1.3-1.3-1.5-1.5-1.6-1.6-1.60.7
Intermittent access day 15 total locomotion0.20.31.1-0.7-0.4-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.2-0.6-0.6-1.0-0.1
Intermittent access total locomotion0.81.01.9-1.1-0.8-0.9-1.0-1.0-1.0-1.2-1.2-1.0-0.7-1.0-1.0-1.40.3
Intermittent access standard deviation1.63.35.3-1.7-1.9-2.0-2.0-1.9-2.0-1.5-1.5-1.9-1.7-2.0-2.0-2.30.8
Left kidney weight0.73.13.61.71.81.91.81.81.81.91.91.81.71.81.91.9-0.7
Right kidney weight0.52.53.01.71.61.71.61.61.71.61.61.61.51.61.71.7-0.6
Cocaine induced anxiety2.63.84.51.91.91.91.91.91.92.12.11.91.91.91.82.0-2.0
Post-drug Anxiety4.85.15.52.32.32.32.32.32.32.22.22.32.32.32.32.2-1.8
Baseline Anxiety0.10.21.3-0.1-0.2-0.2-0.2-0.2-0.2-0.6-0.6-0.2-0.1-0.2-0.1-0.41.1
Tail length3.413.114.53.63.73.63.73.73.73.63.63.83.73.73.63.6-3.0
Length with tail5.323.125.85.04.94.94.94.94.95.15.14.94.94.84.84.6-3.2
Length without tail2.78.611.63.23.03.02.92.92.93.43.42.93.02.72.82.5-2.0
Times rat made contact with spout0.30.40.50.60.70.70.60.60.60.60.60.60.60.60.70.70.1
Lifetime Intake0.50.60.9-0.7-0.6-0.7-0.8-0.8-0.8-0.9-0.9-0.8-0.6-0.8-0.8-0.90.3
Liver weight, left2.03.34.11.91.71.81.91.91.92.02.01.91.61.91.92.0-0.5
Liver weight, right0.50.81.3-0.7-1.0-0.8-0.9-1.0-0.9-0.8-0.8-0.9-1.1-1.0-1.0-0.61.0
Locomotor activity0.10.20.40.20.60.50.40.40.30.30.30.20.50.30.4-0.1-0.6
Locomotor testing distance0.20.30.80.20.90.80.60.60.50.30.30.50.80.50.5-0.1-0.5
Locomotor testing rearing1.22.45.7-1.6-1.1-1.3-1.5-1.6-1.6-1.7-1.7-1.6-1.1-1.8-1.6-2.40.7
Locomotion in novel chamber2.43.14.41.81.81.91.91.92.01.41.41.81.61.91.92.1-1.0
Locomotion in novel chamber post-restriction0.00.10.2-0.0-0.4-0.3-0.2-0.1-0.1-0.1-0.1-0.1-0.50.0-0.20.30.3
Fecal boli incidents, locomotor time 11.52.13.3-1.7-1.8-1.7-1.5-1.5-1.4-1.4-1.4-1.2-1.7-1.3-1.5-0.91.5
Change in fecal boli incidents, locomotor task0.10.10.20.40.30.30.20.20.2-0.0-0.0-0.00.30.20.30.10.1
Time >=10cm from walls, locomotor time 10.60.62.9-0.6-0.8-0.7-0.7-0.7-0.6-0.7-0.7-0.6-0.8-0.7-0.6-0.41.7
Bouts of movement, locomotor time 11.11.31.8-1.1-1.3-1.2-1.1-1.1-1.1-1.2-1.2-1.0-1.3-1.0-1.2-0.91.0
Total resting periods, locomotor time 11.21.31.8-1.1-1.3-1.2-1.1-1.1-1.1-1.2-1.2-1.1-1.3-1.0-1.2-1.00.9
Rest time, locomotor task time 10.10.20.60.50.30.30.40.40.50.30.30.30.20.50.50.8-0.1
Distance moved, locomotor task time 10.20.41.5-0.5-0.2-0.5-0.6-0.6-0.7-0.5-0.5-0.6-0.2-0.7-0.7-1.2-0.5
Vertical activity count, locomotor time 10.30.81.20.91.10.90.90.90.81.01.00.91.10.70.70.3-0.9
Time >=10cm from walls, locomotor time 20.30.40.60.80.70.70.70.70.70.60.60.60.70.70.60.6-0.5
Bouts of movement, locomotor time 21.32.03.11.31.21.41.51.51.61.41.41.61.21.71.51.8-0.4
Total resting periods, locomotor time 20.91.62.91.21.11.31.31.31.41.21.21.40.91.51.31.7-0.1
Rest time, locomotor task time 20.30.31.50.50.30.50.60.60.70.10.10.40.10.80.71.20.2
Distance moved, locomotor task time 20.30.41.8-0.4-0.1-0.4-0.5-0.5-0.6-0.2-0.2-0.5-0.0-0.7-0.7-1.3-1.2
Vertical activity count, locomotor time 20.71.04.91.01.10.80.80.80.61.11.10.81.10.70.60.0-2.2
Light reinforcement 10.00.00.1-0.10.1-0.0-0.1-0.1-0.1-0.2-0.2-0.10.1-0.2-0.0-0.30.2
Light reinforcement 21.21.92.6-1.5-1.5-1.6-1.4-1.3-1.4-1.5-1.5-1.3-1.4-1.2-1.3-1.10.8
Bone: marrow area0.30.61.0-1.0-1.0-0.9-0.8-0.8-0.7-0.7-0.7-0.6-0.9-0.7-0.6-0.21.0
Bone: maximum diameter0.00.00.3-0.2-0.3-0.20.00.00.1-0.2-0.20.0-0.30.2-0.00.5-0.0
Bone: maximum force0.00.10.2-0.00.10.00.20.30.20.20.20.30.20.40.20.2-0.4
Bone: maximum moment0.00.10.2-0.2-0.0-0.00.20.20.10.10.10.30.10.40.20.2-0.5
Mean time between licks in bursts0.51.21.6-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.1-1.1-1.30.4
Mean num. licks in bursts0.00.00.10.00.30.20.10.10.1-0.1-0.10.10.3-0.00.1-0.10.0
Cd content in liver0.10.10.4-0.0-0.1-0.0-0.0-0.00.0-0.4-0.4-0.2-0.2-0.0-0.10.00.6
Co content in liver1.21.42.31.11.21.11.11.11.11.51.51.51.51.11.20.7-0.1
Cu content in liver0.50.60.8-0.8-0.9-0.9-0.8-0.8-0.8-0.7-0.7-0.8-0.9-0.8-0.8-0.60.8
Fe content in liver0.40.51.4-0.7-0.7-0.6-0.7-0.7-0.6-0.6-0.6-0.7-0.7-0.6-0.6-0.41.2
K content in liver0.40.40.70.70.70.60.60.60.50.80.80.80.80.50.70.30.2
Mg content in liver0.30.30.70.60.70.60.50.50.40.70.70.70.80.40.60.10.3
Mn content in liver0.20.30.8-0.5-0.4-0.5-0.5-0.5-0.6-0.5-0.5-0.3-0.2-0.6-0.5-0.90.4
Na content in liver0.00.00.1-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.2-0.2-0.2
Rb content in liver0.70.81.00.81.00.90.90.90.90.80.81.01.00.91.00.90.0
Se content in liver0.20.20.6-0.5-0.8-0.6-0.4-0.4-0.4-0.3-0.3-0.3-0.7-0.2-0.30.50.2
Sr content in liver0.20.20.30.30.30.30.50.50.40.30.30.50.40.60.40.6-0.6
Zn content in liver1.51.73.21.31.01.11.31.31.31.51.51.31.01.41.31.8-0.7
Bone: minimum diameter0.30.61.00.60.70.70.80.80.80.80.80.80.70.90.91.0-0.4
Time in familiar zone, hab. session 10.50.51.7-0.4-0.3-0.5-0.7-0.7-0.8-0.5-0.5-0.7-0.3-1.0-0.7-1.30.4
Time in novel zone, hab. session 10.10.10.4-0.5-0.6-0.4-0.2-0.2-0.2-0.5-0.5-0.2-0.6-0.0-0.20.50.1
Total zone transitions, hab. session 10.60.91.3-1.1-1.0-1.0-0.9-0.9-1.0-0.9-0.9-1.0-0.9-0.9-1.0-1.10.3
Total locomotion distance, hab. session 10.00.00.10.00.20.10.10.10.10.10.10.00.20.10.0-0.2-0.2
Locomotion velocity, hab. session 10.30.50.60.60.80.80.70.80.70.70.70.70.80.70.60.2-0.5
Time in familiar zone, hab. session 20.60.61.8-0.5-0.4-0.6-0.8-0.8-0.8-0.8-0.8-0.9-0.6-1.0-0.9-1.30.5
Time in novel zone, hab. session 20.10.10.2-0.4-0.4-0.3-0.1-0.1-0.1-0.1-0.1-0.1-0.30.1-0.10.4-0.0
Total zone transitions, hab. session 20.70.81.5-1.1-1.0-1.1-0.9-0.9-1.0-0.8-0.8-0.9-0.8-0.8-1.0-1.20.2
Total locomotion distance, hab. session 20.40.50.70.60.70.60.70.80.70.80.80.70.80.80.70.3-0.8
Locomotion velocity, hab. session 20.60.81.00.80.90.80.90.90.91.01.00.91.01.00.80.5-0.8
Novel to familiar place preference ratio0.30.30.6-0.8-0.8-0.7-0.6-0.6-0.6-0.5-0.5-0.4-0.6-0.4-0.5-0.20.5
Novelty place preference0.20.20.4-0.6-0.6-0.5-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.20.4
Time in novel zone, NPP test0.10.20.3-0.6-0.6-0.5-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.3-0.3-0.10.4
Total zone transitions, NPP test0.10.20.4-0.6-0.5-0.5-0.4-0.4-0.5-0.3-0.3-0.3-0.3-0.3-0.4-0.6-0.2
Total locomotion distance, NPP test0.00.00.3-0.10.00.00.20.20.10.20.20.20.20.30.2-0.0-0.5
Locomotion velocity, NPP test0.00.10.3-0.00.10.10.30.30.20.30.30.30.30.40.20.0-0.5
Intraocular pressure0.00.10.4-0.1-0.2-0.1-0.2-0.2-0.2-0.0-0.0-0.2-0.2-0.2-0.2-0.40.6
Delta distance traveled before/after self-admin0.10.10.4-0.2-0.0-0.2-0.1-0.1-0.2-0.2-0.2-0.00.2-0.1-0.1-0.6-0.4
Delta ambulatory time before/after self-admin0.40.50.90.60.80.60.70.80.70.50.50.81.00.80.70.2-0.9
Parametrial fat weight0.40.91.9-1.0-1.2-1.1-1.0-1.0-0.9-0.8-0.8-1.0-1.4-0.8-1.0-0.30.6
Pavlov. Cond. lever latency0.50.60.80.90.80.80.80.80.80.80.80.70.70.80.80.7-0.6
Pavlov. Cond. magazine entry latency0.50.61.1-0.9-0.7-0.8-0.8-0.8-0.9-0.9-0.9-0.7-0.6-0.9-0.8-1.00.2
Pavlov. Cond. change in total contacts0.30.30.7-0.5-0.4-0.4-0.6-0.6-0.6-0.6-0.6-0.5-0.3-0.7-0.6-0.80.1
Pavlov. Cond. index score0.81.01.3-1.1-1.0-1.0-1.0-1.0-1.1-1.0-1.0-0.9-0.9-1.0-1.1-1.10.5
Pavlov. Cond. latency score0.50.60.9-1.0-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.8-0.9-0.80.5
Pavlov. Cond. lever contacts0.91.01.3-1.1-1.0-1.0-1.1-1.1-1.1-1.0-1.0-0.9-1.0-1.1-1.1-1.00.6
Pavlov. Cond. magazine entry number0.91.11.71.21.01.11.11.11.21.11.11.00.91.21.11.3-0.3
Pavlov. Cond. intertrial magazine entries5.16.16.82.62.52.52.62.62.62.62.62.52.42.62.52.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.0-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.7-0.7-0.9-0.9-1.00.3
Pavlov. Cond. response bias1.51.82.4-1.5-1.3-1.4-1.4-1.4-1.5-1.4-1.4-1.3-1.2-1.4-1.4-1.60.4
Pavlov. Cond. lever latency2.23.03.71.91.81.91.81.81.91.81.81.71.71.81.81.7-0.6
Pavlov. Cond. magazine entry latency4.85.86.9-2.4-2.5-2.5-2.5-2.5-2.4-2.5-2.5-2.5-2.6-2.4-2.4-1.91.7
Pavlov. Cond. change in total contacts3.35.36.1-2.3-2.3-2.4-2.4-2.4-2.4-2.3-2.3-2.5-2.3-2.5-2.4-2.21.2
Pavlov. Cond. index score4.96.67.2-2.7-2.6-2.7-2.7-2.7-2.7-2.6-2.6-2.7-2.6-2.7-2.6-2.31.4
Pavlov. Cond. latency score4.86.47.0-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.7-2.6-2.21.5
Pavlov. Cond. lever contacts3.04.14.9-2.2-2.1-2.2-2.1-2.1-2.2-2.1-2.1-2.0-2.0-2.1-2.1-2.00.7
Pavlov. Cond. magazine entry number4.25.26.02.22.32.32.42.42.42.32.32.42.42.42.32.1-1.7
Pavlov. Cond. intertrial magazine entries4.56.89.02.82.92.72.62.62.62.92.92.73.02.52.71.8-1.5
Pavlov. Cond. lever-magazine prob. diff.5.47.28.1-2.8-2.7-2.8-2.8-2.8-2.8-2.8-2.8-2.8-2.8-2.8-2.7-2.41.5
Pavlov. Cond. response bias3.95.36.0-2.4-2.3-2.4-2.4-2.4-2.4-2.4-2.4-2.4-2.3-2.4-2.4-2.31.0
Time in closed arm before self-admin1.72.23.2-1.5-1.7-1.6-1.5-1.5-1.4-1.5-1.5-1.7-1.8-1.4-1.5-1.20.4
Time in closed arm after self-admin0.80.91.5-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.9-1.2-1.2-0.9-1.0-0.7-0.3
Time in open arm before self-admin2.02.22.81.71.61.71.51.51.51.41.41.51.51.51.41.4-0.7
Time in open arm after self-admin2.02.23.21.81.51.51.51.51.51.51.51.61.41.51.61.60.4
Bone: periosteal estimation0.00.10.3-0.2-0.2-0.10.20.20.20.10.10.3-0.00.30.20.60.1
Bone: periosteal perimeter0.00.10.3-0.4-0.4-0.2-0.00.0-0.0-0.1-0.1-0.0-0.30.2-0.00.5-0.1
Bone: post-yield work1.01.41.81.21.21.21.21.31.21.21.21.11.21.31.31.3-0.7
Progressive ratio test 1 active lever presses0.20.30.5-0.3-0.3-0.4-0.5-0.5-0.5-0.7-0.7-0.6-0.4-0.6-0.6-0.6-0.2
Progressive ratio test 1 breakpoint0.30.40.6-0.4-0.5-0.5-0.6-0.7-0.7-0.8-0.8-0.7-0.6-0.7-0.7-0.80.2
Progressive ratio test 1 inactive lever presses1.52.25.51.51.61.41.31.31.21.71.71.31.51.21.20.9-2.3
Progressive ratio test 2 active lever presses0.10.10.20.30.40.30.30.30.20.30.30.20.30.20.20.2-0.5
Progressive ratio test 2 breakpoint0.10.10.20.30.40.30.30.30.20.30.30.20.30.20.20.2-0.4
Progressive ratio test 2 inactive lever presses0.81.32.01.31.21.11.01.01.01.31.30.91.00.91.00.9-1.4
Incentive Sensitization - Responses0.10.20.40.30.40.40.40.40.40.60.60.30.20.40.40.5-0.3
Incentive Sensitization - Breakpoint0.20.20.40.40.50.50.40.40.50.60.60.40.30.40.50.6-0.4
Sum of active levers in priming session hrs 5-60.10.10.40.40.50.30.30.30.30.40.40.40.60.30.3-0.3-0.0
Progressive ratio0.20.42.90.40.40.40.40.40.40.50.50.40.40.40.40.3-1.7
Food seeking constrained by brief footshock2.12.65.31.31.51.51.61.61.51.51.51.61.61.71.51.7-2.3
Seeking ratio, punishment vs. effort0.10.10.20.20.40.30.40.40.30.20.20.30.40.40.30.4-0.1
Retroperitoneal fat weight0.10.51.3-0.6-0.9-0.7-0.7-0.7-0.6-0.4-0.4-0.7-1.0-0.6-0.60.11.1
Reaction time number correct2.24.35.62.42.32.32.12.12.12.22.22.12.21.92.11.6-0.8
Reaction time mean minus median0.00.10.4-0.4-0.5-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.6-0.2-0.30.2-0.0
Reaction time mean minus median AUC0.10.20.5-0.4-0.6-0.4-0.3-0.3-0.3-0.3-0.3-0.4-0.7-0.2-0.40.2-0.4
Reaction time num false alarms0.81.11.70.91.31.31.11.11.10.90.91.11.21.01.10.9-1.0
Reaction time num false alarms AUC1.21.82.41.21.51.51.41.41.41.11.11.41.41.31.41.3-1.3
Reaction time trials correct on left2.24.35.62.42.32.32.12.12.12.22.22.12.21.92.11.6-0.8
Reaction time trials on left2.34.35.62.42.32.22.12.12.12.22.22.12.21.92.11.6-0.8
Reaction time mean0.61.01.3-1.1-1.1-1.1-1.1-1.1-1.1-0.9-0.9-1.0-1.1-1.0-1.0-0.80.5
Reaction time mean AUC0.40.60.9-0.9-1.0-0.9-0.9-0.8-0.8-0.7-0.7-0.8-0.9-0.8-0.8-0.60.4
Median of all reaction times0.40.60.8-0.9-0.8-0.9-0.9-0.9-0.9-0.7-0.7-0.8-0.7-0.9-0.7-0.90.4
Reaction time omissions0.40.60.90.80.60.60.70.70.70.90.90.80.70.80.81.0-0.4
Reaction time false alarm rate0.10.10.60.00.30.40.30.30.30.10.10.30.20.30.30.5-0.8
Reaction time premature initiation rate0.81.11.31.01.21.11.11.11.11.01.01.11.11.11.11.0-0.6
Reaction time premature initiations2.03.54.52.02.12.12.01.92.01.91.92.02.01.82.01.5-0.9
Std. dev. reaction times0.20.30.9-0.7-0.9-0.7-0.6-0.6-0.5-0.5-0.5-0.5-0.9-0.4-0.60.10.1
Reaction time trials completed2.34.35.62.42.32.22.12.12.12.22.22.12.21.92.11.6-0.8
Reaction time trials AUC2.44.66.22.52.42.42.22.22.22.32.32.22.32.02.21.7-0.8
Run reversals in cocaine runway, females0.40.40.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.6-0.50.2
Run reversals in cocaine runway, males1.21.21.71.21.21.11.11.11.01.31.31.31.31.01.11.00.1
Latency to leave start box in cocaine runway0.50.55.6-0.5-0.2-0.2-0.4-0.4-0.3-0.6-0.6-0.0-0.2-0.5-0.3-0.52.4
Latency to leave start box in cocaine runway, F0.20.21.5-0.4-0.0-0.1-0.2-0.3-0.3-0.4-0.40.00.0-0.4-0.2-0.71.2
Latency to leave start box in cocaine runway, M0.50.55.7-0.4-0.4-0.2-0.3-0.3-0.2-0.4-0.4-0.0-0.4-0.2-0.20.02.4
Std. dev. time between licks in bursts0.71.01.7-1.2-1.0-1.0-1.0-0.9-1.0-1.1-1.1-1.0-0.8-0.9-1.0-1.30.5
Total sessions with >9 infusions0.30.31.0-0.5-0.3-0.5-0.6-0.6-0.7-0.5-0.5-0.6-0.3-0.7-0.7-1.0-0.4
Short access day 1 total inactive lever presses0.00.00.20.10.20.1-0.0-0.0-0.00.10.1-0.10.1-0.10.0-0.3-0.5
Short access day 10 total inactive lever presses0.00.00.10.2-0.2-0.1-0.1-0.1-0.10.10.1-0.1-0.3-0.1-0.10.20.1
Short access day 1 total infusions0.20.20.40.40.60.50.40.40.40.40.40.40.60.40.40.2-0.5
Short access day 10 total infusions0.81.11.6-0.8-0.9-0.9-1.0-1.0-1.0-1.3-1.3-1.1-1.0-1.1-1.0-1.00.8
Short access total infusions0.20.30.5-0.6-0.4-0.5-0.5-0.5-0.6-0.7-0.7-0.6-0.4-0.6-0.6-0.60.1
Short access day 1 locomotion0.40.51.2-0.6-0.4-0.6-0.7-0.7-0.7-0.6-0.6-0.8-0.5-0.8-0.8-1.1-0.2
Short access day 10 total locomotion1.73.26.3-1.9-1.6-1.8-1.8-1.8-1.9-1.7-1.7-1.9-1.5-1.9-2.0-2.50.2
Short access total locomotion0.30.41.5-0.6-0.4-0.6-0.6-0.6-0.7-0.5-0.5-0.6-0.3-0.7-0.7-1.2-0.0
One hour access (0.3 mA shock)0.00.00.20.30.30.20.20.20.10.20.20.10.20.10.1-0.2-0.4
Compulsive drug intake0.00.10.40.20.10.10.10.10.10.20.20.10.10.10.20.3-0.7
One hour access (shock baseline)0.00.00.2-0.00.10.10.00.00.0-0.1-0.10.00.10.0-0.1-0.40.2
Social response proportion0.20.20.50.70.50.40.50.40.50.50.50.30.30.40.60.7-0.2
Social responses0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.1-0.2-0.20.1-0.3
Social time0.71.02.51.00.90.81.01.01.01.01.01.00.71.01.11.6-1.0
Soleus weight0.00.10.2-0.2-0.2-0.3-0.4-0.4-0.4-0.3-0.3-0.3-0.2-0.5-0.3-0.40.2
Bone: stiffness0.81.31.80.91.01.01.21.21.11.11.11.21.01.31.21.3-1.2
Tibialis anterior weight0.20.60.80.90.80.90.80.80.80.70.70.80.70.80.80.8-0.7
Time to tail flick, vehicle, before self-admin0.30.30.70.50.50.50.60.60.60.50.50.50.40.60.50.7-0.9
Time to tail flick, vehicle, after self-admin0.40.50.8-0.6-0.8-0.7-0.8-0.8-0.8-0.6-0.6-0.9-0.9-0.7-0.9-0.6-0.4
Time to tail flick, test, before self-admin0.00.00.00.20.10.00.10.10.0-0.1-0.10.10.10.1-0.00.1-0.2
Time to tail flick, test, after self-admin0.90.92.01.10.80.90.90.90.91.11.10.60.70.90.80.9-1.4
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.1-0.1-0.1-0.2-0.2-0.2-0.0-0.0-0.2-0.0-0.2-0.2-0.3-0.1
Delta time to tail flick, test, before/after SA0.50.50.80.70.60.70.60.60.70.90.90.50.40.70.70.8-0.7
Tibia length0.51.42.10.90.91.01.21.21.21.21.21.21.11.31.11.4-1.4
Ambulatory time before self-admin0.50.73.0-0.5-0.9-0.6-0.9-0.9-0.8-0.5-0.5-0.7-1.0-0.9-0.8-0.51.7
Ambulatory time after self-admin0.10.20.6-0.1-0.4-0.3-0.4-0.4-0.4-0.2-0.2-0.2-0.3-0.4-0.4-0.50.8
Bone: tissue strength0.20.20.40.30.30.30.50.50.50.40.40.50.30.60.50.6-0.5
Total heroin consumption2.63.14.41.71.91.81.81.81.71.71.71.82.11.81.71.1-1.8
Bone: trabecular number0.00.00.00.10.00.0-0.0-0.0-0.00.00.0-0.1-0.0-0.1-0.00.1-0.1
Bone: trabecular spacing0.00.00.0-0.1-0.2-0.2-0.0-0.0-0.0-0.0-0.00.1-0.10.1-0.10.2-0.1
Bone: trabecular thickness0.10.10.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.2-0.3-0.2-0.3-0.3-0.4-0.1
Bone: trabecular tissue density0.10.10.30.40.50.40.30.30.20.40.40.10.50.10.3-0.1-0.3
Water consumed over 24 hours2.43.23.71.71.81.91.81.81.91.81.81.91.81.81.91.9-0.6
Number of responses in last shaping day0.10.10.3-0.5-0.5-0.5-0.4-0.4-0.4-0.0-0.0-0.3-0.3-0.3-0.4-0.40.5