Hub : Genes

Eif5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Eif5 0.27 0.15 4.0e-14 0.26 0.25 0.21 0.26 5.7e-14 1.5e-13 1.1e-11 5.6e-14
2 PL mRNA stability Eif5 0.19 0.1 0.0e+00 0.28 0.28 0.27 0.28 2.9e-30 1.3e-30 3.6e-30 1.1e-30
3 NAcc mRNA stability Eif5 0.11 0.07 0.0e+00 0.16 0.16 0.16 0.16 1.9e-18 1.6e-18 3.7e-18 2.8e-18
4 Liver mRNA stability Eif5 0.26 0.19 0.0e+00 0.17 0.18 0.18 0.18 1.2e-18 3.2e-19 4.1e-19 3.3e-19
5 Liver gene expression Eif5 0.07 0.06 2.3e-08 0.06 0.06 0.06 0.06 4.2e-07 3.6e-07 4.1e-07 5.0e-07
6 LHb mRNA stability Eif5 0.2 0.14 2.2e-04 0.15 0.16 0.15 0.15 2.6e-04 1.3e-04 1.7e-04 2.3e-04
7 Adipose gene expression Eif5 0.04 0.04 1.7e-04 0.03 0.03 0.02 0.02 6.3e-04 6.8e-04 3.5e-03 9.9e-04
8 Adipose mRNA stability Eif5 0.49 0.27 0.0e+00 0.3 0.3 0.3 0.3 1.2e-33 9.0e-34 1.5e-33 1.0e-33
9 OFC mRNA stability Eif5 0.37 0.23 1.6e-05 0.15 0.14 0.16 0.15 1.7e-04 3.1e-04 1.2e-04 2.3e-04
10 Brain mRNA stability Eif5 0.5 0.19 0.0e+00 0.29 0.26 0.26 0.26 6.3e-27 2.2e-24 2.0e-24 2.0e-24
11 IL mRNA stability Eif5 0.13 0.12 6.8e-03 0.09 0.09 0.1 0.09 3.4e-03 3.6e-03 2.8e-03 2.9e-03
12 pVTA mRNA stability Eif5 0.14 0.12 6.1e-05 0.1 0.09 0.1 0.1 2.9e-05 7.9e-05 5.4e-05 3.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.10.3-0.2-0.3-0.2-0.2-0.2-0.20.2-0.20.20.20.20.5
Area under the delay curve0.10.10.4-0.2-0.1-0.3-0.4-0.3-0.30.3-0.20.30.40.3-0.6
BMI with tail2.37.39.1-2.9-2.6-2.9-3.0-2.8-2.82.9-2.72.92.72.90.9
BMI without tail0.61.21.9-1.2-0.9-1.1-1.4-1.0-1.01.2-1.11.21.01.2-0.4
Body weight0.10.62.70.60.90.60.50.60.6-0.50.7-0.5-0.6-0.5-1.6
Weight adjusted by age0.10.10.60.10.20.10.00.10.1-0.20.1-0.2-0.2-0.2-0.7
Bone surface0.00.00.1-0.3-0.2-0.2-0.2-0.2-0.10.1-0.30.10.00.10.3
Bone volume0.00.10.3-0.3-0.2-0.2-0.2-0.2-0.20.1-0.30.10.10.10.5
Breakpoint value in progressive ratio session0.00.00.1-0.1-0.2-0.1-0.0-0.1-0.0-0.0-0.1-0.0-0.0-0.00.3
Number of licking bursts0.10.10.50.20.30.30.20.30.3-0.30.2-0.2-0.4-0.2-0.7
Context. condit. distance diff. score1.72.12.51.51.41.51.61.51.5-1.51.5-1.5-1.5-1.5-0.9
Locomotion velocity, session 10.20.30.40.40.40.50.60.50.6-0.60.5-0.5-0.7-0.4-0.2
Locomotion distance, session 10.40.51.5-0.8-0.8-0.6-0.5-0.7-0.60.5-0.60.50.50.61.2
Locomotion velocity, session 20.00.00.30.1-0.0-0.10.1-0.1-0.2-0.00.0-0.0-0.1-0.00.6
Locomotion distance, session 20.40.51.1-0.7-0.7-0.6-0.6-0.6-0.60.7-0.70.70.70.71.0
Locomotion velocity, session 30.20.20.9-0.4-0.5-0.4-0.3-0.4-0.50.4-0.30.30.40.30.9
Locomotion distance, session 30.00.00.00.10.10.20.20.10.2-0.10.2-0.2-0.1-0.20.2
Stereotopy head waving bouts, day 30.20.20.40.40.40.40.40.40.4-0.50.4-0.5-0.6-0.5-0.3
Stereotopy head waving duration, day 30.20.30.50.60.50.50.50.50.5-0.60.5-0.6-0.7-0.6-0.0
Locomotion velocity, session 70.40.41.9-0.4-0.6-0.6-0.4-0.6-0.70.7-0.50.50.70.51.4
Locomotion distance, session 70.91.11.7-1.0-1.1-1.0-0.9-1.0-1.01.2-1.01.01.21.01.3
Stereotopy head waving bouts, day 70.91.01.31.11.01.01.01.01.0-1.11.0-1.0-1.1-1.0-0.6
Stereotopy head waving duration, day 70.30.40.60.70.60.60.60.60.6-0.70.7-0.7-0.8-0.7-0.4
Locomotion velocity, session 80.10.20.30.40.40.40.60.40.4-0.40.5-0.4-0.4-0.40.1
Locomotion distance, session 80.10.10.6-0.2-0.3-0.1-0.0-0.1-0.10.2-0.20.10.10.10.8
Degree of sensitization distance0.10.10.2-0.3-0.3-0.4-0.4-0.4-0.40.4-0.40.40.50.40.2
Degree of sensitization stereotypy0.20.20.30.50.40.50.50.50.5-0.50.4-0.5-0.5-0.5-0.1
Conditioned locomotion1.31.51.91.31.21.21.31.21.2-1.31.2-1.3-1.3-1.4-0.9
Cocaine response after cond. corrected0.50.60.7-0.8-0.7-0.7-0.8-0.7-0.70.8-0.80.80.70.80.7
Cocaine response after cond. not corrected1.92.12.3-1.4-1.4-1.4-1.5-1.4-1.41.5-1.51.51.51.51.2
Cocaine response before conditioning2.42.93.3-1.7-1.8-1.7-1.7-1.7-1.81.8-1.61.71.81.71.4
Saline control response0.30.30.7-0.5-0.6-0.5-0.5-0.5-0.50.6-0.60.60.50.60.8
Bone: connectivity density0.00.10.10.30.20.20.30.20.2-0.20.3-0.3-0.2-0.30.1
Bone: cortical apparent density8.611.412.13.53.43.43.53.43.3-3.43.5-3.4-3.4-3.4-3.0
Bone: cortical area1.11.72.11.11.31.31.21.31.4-1.41.1-1.3-1.4-1.3-1.1
Bone: cortical porosity0.00.00.30.0-0.1-0.00.1-0.0-0.0-0.10.0-0.1-0.2-0.10.5
Bone: cortical porosity0.30.30.9-0.5-0.6-0.5-0.4-0.5-0.50.4-0.50.40.40.50.9
Bone: cortical thickness1.01.62.11.21.21.31.31.31.4-1.41.1-1.4-1.4-1.3-0.7
Bone: cortical thickness0.70.81.20.90.91.00.91.01.1-0.80.8-0.9-0.9-0.9-0.8
Bone: cortical tissue density8.811.612.23.53.43.43.53.43.4-3.43.5-3.4-3.4-3.4-3.1
Condit. Reinf. active minus inactive responses0.50.60.9-0.7-0.8-0.7-0.8-0.7-0.70.9-0.80.80.90.80.2
Condit. Reinf. active-inactive response ratio2.42.62.9-1.6-1.6-1.6-1.7-1.6-1.61.7-1.71.61.71.61.1
Condit. Reinf. active responses0.20.20.4-0.3-0.5-0.4-0.4-0.4-0.50.6-0.50.50.60.40.5
Condit. Reinf. inactive responses1.82.12.51.51.41.51.61.51.4-1.51.5-1.5-1.5-1.6-0.9
Incentive salience index mean0.40.50.6-0.7-0.7-0.7-0.8-0.7-0.70.7-0.70.70.80.70.3
Condit. Reinf. lever presses0.10.10.2-0.3-0.4-0.4-0.3-0.4-0.40.1-0.40.20.20.20.4
Condit. Reinf. active minus inactive responses0.30.40.50.60.70.60.70.60.6-0.60.7-0.6-0.7-0.6-0.6
Condit. Reinf. active-inactive response ratio0.40.40.60.60.70.60.70.70.6-0.60.7-0.6-0.6-0.6-0.8
Condit. Reinf. active responses0.00.00.0-0.0-0.0-0.1-0.0-0.1-0.10.20.00.10.10.10.1
Condit. Reinf. inactive responses0.60.80.9-0.9-0.9-0.9-0.9-0.9-0.91.0-0.90.90.90.90.8
Condit. Reinf. lever presses1.72.42.6-1.5-1.5-1.5-1.5-1.5-1.51.6-1.51.61.51.51.6
Condit. Reinf. lever reinforcers received0.00.00.0-0.1-0.0-0.1-0.1-0.1-0.20.2-0.00.20.10.10.1
Conditioned reinforcement - actives2.02.02.31.51.41.41.51.41.4-1.51.5-1.5-1.4-1.5-0.9
Conditioned reinforcement - inactives0.30.30.40.60.60.60.70.60.6-0.60.6-0.6-0.6-0.6-0.1
Conditioned locomotion0.81.02.4-0.9-1.1-0.9-0.8-1.0-1.00.8-1.00.80.90.81.5
Patch foraging indifference point 0 sec3.15.05.72.42.42.32.32.22.2-2.22.3-2.2-2.1-2.3-1.9
Patch foraging indifference point AUC2.73.13.51.91.81.81.81.81.7-1.81.8-1.8-1.8-1.8-1.5
Delay disc. indifference point, 0s delay0.10.10.20.40.30.30.30.30.2-0.20.3-0.2-0.1-0.2-0.5
Delay disc. indifference point, 16s delay0.00.00.2-0.2-0.1-0.2-0.2-0.2-0.20.1-0.00.00.20.0-0.4
Delay disc. indifference point, 2s delay0.10.10.1-0.2-0.2-0.2-0.3-0.2-0.20.4-0.30.40.30.4-0.0
Delay disc. indifference point, 24s delay0.10.10.7-0.3-0.1-0.2-0.3-0.1-0.10.1-0.10.20.20.2-0.9
Delay disc. indifference point, 4s delay0.20.21.60.40.50.30.20.30.3-0.20.4-0.2-0.1-0.3-1.3
Delay disc. indifference point, 8s delay0.20.20.4-0.3-0.2-0.5-0.6-0.5-0.50.5-0.40.50.60.5-0.6
Indifference point function ln k0.50.60.80.80.80.80.70.80.8-0.80.7-0.8-0.9-0.7-0.8
Indifference point function log k0.50.60.80.80.80.80.70.80.8-0.80.7-0.8-0.9-0.7-0.8
Patch foraging total patch changes 0 sec3.45.56.42.52.52.42.42.32.3-2.32.4-2.3-2.2-2.4-2.0
Patch foraging total patch changes 12 sec3.64.65.42.32.32.12.22.12.0-2.22.2-2.2-2.0-2.3-1.7
Patch foraging total patch changes 18 sec1.62.12.91.61.41.31.61.31.2-1.51.6-1.6-1.5-1.7-0.6
Patch foraging total patch changes 24 sec0.20.20.30.50.50.40.40.40.3-0.40.5-0.4-0.3-0.4-0.5
Patch foraging total patch changes 6 sec2.02.93.81.81.91.71.71.71.6-1.61.8-1.6-1.5-1.6-2.0
Patch foraging time to switch 0 sec10.816.718.1-4.3-4.1-4.2-4.2-4.1-4.14.2-4.14.14.14.13.3
Patch foraging water rate 0 sec18.229.331.95.65.65.55.55.55.5-5.45.4-5.4-5.3-5.4-4.7
Patch foraging water rate 12 sec9.414.316.23.83.93.83.73.83.8-3.73.7-3.7-3.7-3.7-4.0
Patch foraging water rate 18 sec5.06.77.12.72.72.62.52.62.7-2.52.5-2.5-2.5-2.5-2.7
Patch foraging water rate 24 sec3.95.56.02.32.42.42.32.42.4-2.32.3-2.3-2.3-2.3-2.4
Patch foraging water rate 6 sec4.46.57.22.72.62.62.62.62.6-2.52.5-2.6-2.5-2.6-2.0
Seeking ratio, delayed vs. immediate footshock0.40.51.00.50.50.50.60.60.6-0.90.6-0.9-1.0-0.9-0.7
Distance traveled before self-admin0.00.00.1-0.1-0.1-0.1-0.2-0.1-0.10.3-0.20.30.30.3-0.1
Distance traveled after self-admin0.40.50.50.70.70.70.70.70.7-0.70.7-0.7-0.7-0.7-0.6
Extensor digitorum longus weight5.923.125.64.74.84.84.84.84.8-5.04.8-4.8-5.1-4.7-4.6
Bone: elastic displacement0.60.60.80.70.70.90.80.90.9-0.90.8-0.8-0.9-0.7-0.6
Bone: elastic work0.10.10.30.20.30.40.40.40.5-0.40.3-0.3-0.5-0.2-0.2
Bone: endosteal estimation0.20.40.6-0.8-0.5-0.6-0.8-0.6-0.60.6-0.70.70.50.7-0.1
Bone: endosteal perimeter0.00.10.5-0.20.1-0.0-0.20.00.10.0-0.10.1-0.10.1-0.7
Epididymis fat weight4.410.411.7-3.2-3.2-3.3-3.3-3.3-3.33.3-3.23.33.43.22.7
Delta time in closed arm before/after self-admin0.10.10.1-0.1-0.2-0.2-0.3-0.2-0.20.3-0.20.30.30.30.1
Delta time in open arm before/after self-admin0.60.51.30.60.80.70.60.70.7-0.70.8-0.7-0.7-0.7-1.2
Diff in mean of infusions in LGA sessions0.00.00.10.20.10.20.20.10.1-0.10.0-0.1-0.2-0.10.3
Delay discount exponential model param0.10.10.60.10.00.20.30.20.2-0.30.1-0.2-0.3-0.20.8
Extinction: sum of active levers before priming0.00.00.4-0.1-0.2-0.10.0-0.1-0.10.0-0.1-0.00.0-0.00.6
Active lever presses in extinction session 61.21.11.31.11.11.11.11.11.1-1.11.0-1.1-1.1-1.1-0.7
Bone: final force0.30.50.70.50.70.70.70.80.8-0.80.6-0.7-0.7-0.6-0.5
Bone: final moment0.40.60.80.60.70.80.80.80.9-0.90.6-0.8-0.8-0.7-0.5
Food consumed during 24 hour testing period0.10.10.20.30.30.40.30.40.4-0.40.3-0.4-0.4-0.4-0.3
Glucose0.81.31.61.31.21.21.21.11.1-1.01.2-1.2-0.9-1.2-0.9
Heart weight0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.10.3-0.20.30.30.30.1
Delay discount hyperbolic model param0.10.10.50.20.10.30.40.20.3-0.30.2-0.3-0.4-0.30.7
Intermittent access intake day 1-15 change1.61.53.6-1.2-1.2-1.2-1.1-1.2-1.21.2-1.21.21.11.21.9
Intermittent access intake escalation1.81.84.1-1.3-1.3-1.2-1.1-1.3-1.31.2-1.31.21.21.22.0
Intermittent access intake escalation 20.20.20.7-0.4-0.4-0.3-0.3-0.3-0.30.2-0.40.20.20.20.8
Intermitt. access day 1 inactive lever presses2.42.52.91.71.71.71.71.71.7-1.51.6-1.5-1.6-1.5-1.2
Intermitt. access day 15 inactive lever presses0.80.81.01.01.01.01.00.90.9-0.81.0-0.8-0.9-0.8-0.7
Intermitt. access escalation Index0.40.31.20.50.60.50.50.60.5-0.40.6-0.4-0.4-0.4-1.1
Intermittent access day 1 total infusions0.40.40.5-0.7-0.6-0.7-0.7-0.7-0.70.7-0.70.70.70.70.3
Intermittent access day 15 total infusions2.02.23.0-1.4-1.4-1.5-1.4-1.5-1.51.5-1.41.51.51.51.7
Intermittent access terminal intake (last 3 days)2.32.53.2-1.5-1.5-1.6-1.5-1.6-1.61.6-1.51.61.61.61.8
Intermittent access total infusions0.80.91.1-0.9-0.9-0.9-0.9-0.9-1.01.0-0.91.01.01.01.0
Intermittent access day 1 locomotion1.01.11.2-1.0-1.0-1.0-1.0-1.0-1.01.1-1.11.11.01.11.0
Intermittent access day 15 total locomotion0.40.41.1-0.6-0.7-0.6-0.5-0.6-0.60.6-0.60.60.60.61.1
Intermittent access total locomotion0.60.61.4-0.7-0.8-0.7-0.7-0.8-0.80.7-0.80.70.70.71.2
Intermittent access standard deviation3.63.84.7-2.0-2.0-2.0-1.9-2.0-2.01.9-2.01.91.91.92.2
Left kidney weight0.61.72.41.41.41.31.31.31.2-1.11.4-1.1-1.2-1.1-1.5
Right kidney weight0.30.71.40.90.90.80.80.80.8-0.71.0-0.7-0.7-0.7-1.2
Cocaine induced anxiety2.93.33.61.81.91.91.81.91.9-1.71.8-1.7-1.9-1.7-1.8
Post-drug Anxiety2.52.83.11.71.71.71.61.71.7-1.61.7-1.6-1.7-1.6-1.8
Baseline Anxiety1.41.51.7-1.3-1.3-1.3-1.2-1.3-1.31.1-1.21.11.31.11.1
Tail length2.98.99.63.03.13.13.03.13.1-3.02.9-3.0-3.0-3.0-2.6
Length with tail4.014.515.74.03.93.94.03.93.9-3.83.8-3.8-3.7-3.9-3.1
Length without tail1.84.04.72.22.02.02.22.01.9-2.02.1-2.1-1.9-2.1-1.2
Times rat made contact with spout0.40.40.60.70.60.60.70.60.6-0.70.7-0.7-0.7-0.8-0.6
Lifetime Intake0.40.50.8-0.6-0.6-0.7-0.6-0.7-0.70.7-0.70.70.70.70.9
Liver weight, left3.25.05.72.22.32.32.22.32.4-2.22.1-2.2-2.2-2.1-2.4
Liver weight, right0.00.00.30.20.20.1-0.10.10.1-0.1-0.0-0.1-0.1-0.1-0.6
Locomotor activity0.00.10.20.40.30.30.40.30.30.00.4-0.2-0.1-0.30.1
Locomotor testing distance0.20.40.70.80.60.70.80.60.6-0.40.6-0.5-0.4-0.60.3
Locomotor testing rearing1.62.56.0-1.2-1.5-1.5-1.3-1.5-1.61.6-1.41.51.61.42.5
Locomotion in novel chamber5.16.28.02.62.72.62.42.62.6-2.32.5-2.3-2.5-2.3-2.8
Locomotion in novel chamber post-restriction0.10.10.2-0.4-0.3-0.3-0.3-0.2-0.20.2-0.30.10.00.1-0.5
Fecal boli incidents, locomotor time 11.41.62.4-1.6-1.4-1.4-1.5-1.3-1.31.2-1.41.21.01.20.4
Change in fecal boli incidents, locomotor task0.10.10.20.40.50.40.40.40.3-0.10.4-0.2-0.0-0.2-0.3
Time >=10cm from walls, locomotor time 10.50.50.6-0.7-0.7-0.7-0.8-0.7-0.70.7-0.70.70.80.80.0
Bouts of movement, locomotor time 10.91.01.4-1.1-1.2-1.1-1.2-1.1-1.00.8-1.20.90.70.90.7
Total resting periods, locomotor time 11.01.11.4-1.2-1.2-1.1-1.2-1.1-1.10.8-1.21.00.81.00.7
Rest time, locomotor task time 10.30.41.70.40.60.50.40.50.6-0.50.6-0.4-0.6-0.4-1.3
Distance moved, locomotor task time 10.60.73.7-0.5-0.7-0.6-0.5-0.7-0.70.7-0.60.70.80.71.9
Vertical activity count, locomotor time 10.50.50.80.90.70.80.90.70.7-0.70.7-0.8-0.6-0.80.3
Time >=10cm from walls, locomotor time 20.60.60.80.80.70.80.80.80.8-0.90.7-0.8-0.8-0.7-0.4
Bouts of movement, locomotor time 22.32.54.51.41.41.51.41.51.6-1.61.4-1.5-1.7-1.5-2.1
Total resting periods, locomotor time 21.81.94.61.21.31.31.11.31.4-1.31.3-1.3-1.5-1.3-2.1
Rest time, locomotor task time 20.50.63.40.50.70.60.40.70.7-0.40.6-0.4-0.5-0.4-1.9
Distance moved, locomotor task time 20.60.74.8-0.4-0.6-0.5-0.3-0.6-0.60.5-0.60.50.50.52.2
Vertical activity count, locomotor time 20.50.60.90.80.60.70.90.70.7-0.80.6-0.8-0.8-0.80.9
Light reinforcement 10.00.00.0-0.1-0.1-0.1-0.1-0.1-0.20.1-0.00.10.20.10.0
Light reinforcement 21.41.92.6-1.6-1.5-1.4-1.4-1.4-1.31.3-1.41.41.31.50.9
Bone: marrow area0.10.30.5-0.7-0.5-0.6-0.7-0.5-0.50.6-0.60.60.40.7-0.1
Bone: maximum diameter0.10.20.60.20.40.30.20.40.5-0.40.2-0.3-0.4-0.3-0.8
Bone: maximum force0.30.50.70.60.70.80.80.80.9-0.80.7-0.7-0.8-0.6-0.6
Bone: maximum moment0.30.50.70.50.70.70.70.80.8-0.80.6-0.7-0.8-0.6-0.5
Mean time between licks in bursts1.01.41.6-1.2-1.3-1.2-1.2-1.2-1.21.2-1.21.21.21.21.1
Mean num. licks in bursts0.00.00.20.20.00.00.20.0-0.0-0.10.1-0.2-0.0-0.30.5
Cd content in liver0.30.30.50.50.60.70.50.70.7-0.50.5-0.5-0.3-0.5-0.7
Co content in liver0.70.81.31.00.91.01.00.90.9-1.10.9-0.9-1.0-0.8-0.3
Cu content in liver1.01.31.7-1.1-1.1-1.1-1.2-1.1-1.11.3-1.11.21.31.20.5
Fe content in liver0.10.10.3-0.4-0.3-0.3-0.3-0.3-0.30.5-0.30.50.50.50.1
K content in liver0.10.10.20.40.30.30.40.30.3-0.40.4-0.4-0.5-0.5-0.1
Mg content in liver0.10.10.40.40.20.20.40.20.2-0.40.4-0.4-0.6-0.4-0.0
Mn content in liver0.10.10.30.2-0.00.10.20.0-0.0-0.20.1-0.3-0.4-0.30.6
Na content in liver0.00.00.0-0.1-0.2-0.1-0.0-0.1-0.10.2-0.00.0-0.1-0.00.1
Rb content in liver0.70.81.11.00.90.90.90.90.8-1.01.0-1.0-0.8-0.9-0.8
Se content in liver0.10.10.5-0.4-0.3-0.2-0.4-0.2-0.10.2-0.30.40.10.4-0.7
Sr content in liver0.30.20.50.40.60.50.40.60.6-0.40.4-0.3-0.4-0.3-0.7
Zn content in liver0.20.20.50.40.40.50.40.50.5-0.70.4-0.5-0.6-0.4-0.3
Bone: minimum diameter0.71.31.51.11.21.11.11.11.2-1.11.1-1.1-1.2-1.1-1.2
Time in familiar zone, hab. session 10.80.72.6-0.6-0.7-0.8-0.6-0.8-0.90.8-0.70.70.80.71.6
Time in novel zone, hab. session 10.10.10.6-0.4-0.2-0.2-0.3-0.1-0.10.2-0.20.30.20.3-0.8
Total zone transitions, hab. session 10.71.01.7-1.0-1.0-0.9-0.8-0.9-0.91.0-1.01.01.01.01.3
Total locomotion distance, hab. session 10.00.00.20.10.10.10.20.10.10.00.1-0.00.0-0.10.4
Locomotion velocity, hab. session 10.30.50.60.70.70.70.80.70.7-0.60.7-0.7-0.6-0.7-0.1
Time in familiar zone, hab. session 20.70.71.6-0.6-0.7-0.8-0.7-0.9-0.90.9-0.80.80.90.81.3
Time in novel zone, hab. session 20.00.00.4-0.2-0.2-0.1-0.2-0.00.00.1-0.10.10.10.1-0.6
Total zone transitions, hab. session 20.70.91.6-1.1-1.0-0.9-0.8-0.9-0.90.9-0.90.90.91.01.3
Total locomotion distance, hab. session 20.30.40.60.60.60.70.80.70.8-0.60.7-0.6-0.6-0.7-0.3
Locomotion velocity, hab. session 20.50.70.90.80.80.90.90.90.9-0.80.8-0.8-0.8-0.9-0.3
Novel to familiar place preference ratio0.30.30.4-0.6-0.6-0.5-0.6-0.5-0.50.5-0.60.50.50.50.1
Novelty place preference0.20.20.2-0.5-0.4-0.4-0.5-0.4-0.40.4-0.40.40.40.40.0
Time in novel zone, NPP test0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.30.3-0.40.30.30.3-0.1
Total zone transitions, NPP test0.10.20.4-0.5-0.5-0.4-0.3-0.4-0.30.3-0.40.40.30.40.6
Total locomotion distance, NPP test0.00.00.10.10.00.20.20.20.3-0.20.1-0.2-0.2-0.10.0
Locomotion velocity, NPP test0.00.10.10.10.10.30.30.30.3-0.30.2-0.2-0.3-0.2-0.0
Intraocular pressure0.00.10.1-0.3-0.2-0.3-0.3-0.3-0.30.3-0.30.30.30.30.0
Delta distance traveled before/after self-admin0.00.00.30.1-0.00.10.20.10.1-0.20.1-0.2-0.2-0.20.5
Delta ambulatory time before/after self-admin0.50.50.70.70.60.70.80.70.7-0.90.7-0.8-0.8-0.8-0.1
Parametrial fat weight0.00.10.5-0.00.10.0-0.10.00.1-0.1-0.0-0.10.1-0.1-0.7
Pavlov. Cond. lever latency0.60.70.90.90.90.91.00.90.9-0.80.9-0.8-0.8-0.8-0.7
Pavlov. Cond. magazine entry latency0.40.60.9-0.7-0.8-0.8-0.8-0.8-0.80.5-0.80.60.50.71.0
Pavlov. Cond. change in total contacts0.30.30.9-0.4-0.5-0.6-0.5-0.6-0.60.4-0.50.40.40.41.0
Pavlov. Cond. index score0.81.01.3-1.1-1.1-1.1-1.1-1.1-1.10.8-1.20.90.81.00.9
Pavlov. Cond. latency score0.50.60.9-0.8-0.9-0.9-0.9-0.9-0.80.6-0.90.70.60.80.7
Pavlov. Cond. lever contacts0.70.91.1-1.0-1.0-1.0-1.0-1.0-1.00.8-1.00.80.80.90.8
Pavlov. Cond. magazine entry number1.01.21.51.11.21.21.21.21.2-1.01.2-1.0-0.9-1.1-1.1
Pavlov. Cond. intertrial magazine entries5.26.36.92.62.62.62.62.62.6-2.32.6-2.5-2.3-2.5-2.3
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-0.9-0.9-0.9-0.9-0.9-0.90.6-1.00.70.60.80.8
Pavlov. Cond. response bias1.11.41.8-1.2-1.2-1.2-1.2-1.2-1.20.9-1.31.00.91.11.3
Pavlov. Cond. lever latency2.43.24.71.81.91.81.71.81.8-1.71.8-1.7-1.7-1.7-2.2
Pavlov. Cond. magazine entry latency5.15.96.4-2.5-2.4-2.4-2.4-2.4-2.42.5-2.42.52.52.52.0
Pavlov. Cond. change in total contacts4.35.96.4-2.4-2.5-2.4-2.3-2.4-2.52.5-2.32.42.52.42.4
Pavlov. Cond. index score5.46.97.2-2.6-2.7-2.6-2.6-2.6-2.72.7-2.62.62.72.62.5
Pavlov. Cond. latency score5.26.56.7-2.6-2.6-2.6-2.5-2.6-2.62.6-2.52.62.62.52.5
Pavlov. Cond. lever contacts3.34.45.4-2.2-2.2-2.1-2.0-2.1-2.12.1-2.12.12.02.12.3
Pavlov. Cond. magazine entry number4.15.15.62.22.32.32.22.32.3-2.42.1-2.3-2.4-2.3-2.0
Pavlov. Cond. intertrial magazine entries5.36.97.72.82.72.62.82.62.5-2.72.7-2.7-2.6-2.8-1.8
Pavlov. Cond. lever-magazine prob. diff.5.97.68.0-2.7-2.8-2.8-2.7-2.8-2.82.8-2.72.82.82.72.7
Pavlov. Cond. response bias4.35.96.2-2.4-2.5-2.4-2.3-2.4-2.42.4-2.42.42.42.42.5
Time in closed arm before self-admin3.03.43.8-2.0-1.9-1.9-1.9-1.9-1.91.8-1.91.81.81.91.5
Time in closed arm after self-admin1.71.72.0-1.3-1.3-1.3-1.4-1.3-1.31.3-1.41.41.41.40.9
Time in open arm before self-admin5.05.56.22.52.42.42.32.42.3-2.32.3-2.3-2.3-2.3-2.1
Time in open arm after self-admin3.23.64.31.92.01.91.91.91.9-1.81.9-1.8-1.8-1.9-2.1
Bone: periosteal estimation0.10.30.90.30.50.50.30.50.6-0.50.3-0.4-0.6-0.4-0.9
Bone: periosteal perimeter0.10.10.70.10.40.30.20.40.5-0.30.2-0.3-0.4-0.2-0.8
Bone: post-yield work1.01.41.71.21.31.31.21.21.2-1.01.2-1.1-1.2-1.2-1.1
Progressive ratio test 1 active lever presses0.00.10.3-0.1-0.1-0.2-0.1-0.2-0.20.2-0.20.20.20.20.6
Progressive ratio test 1 breakpoint0.10.10.5-0.3-0.3-0.3-0.3-0.4-0.40.3-0.30.30.40.30.7
Progressive ratio test 1 inactive lever presses2.52.73.21.81.71.71.81.71.7-1.71.7-1.7-1.7-1.7-0.9
Progressive ratio test 2 active lever presses0.00.00.2-0.1-0.1-0.1-0.1-0.1-0.10.2-0.10.20.20.20.4
Progressive ratio test 2 breakpoint0.00.00.1-0.0-0.1-0.1-0.1-0.1-0.10.2-0.10.20.20.20.4
Progressive ratio test 2 inactive lever presses0.70.91.11.01.01.01.01.00.9-0.90.9-0.9-0.9-0.9-0.5
Incentive Sensitization - Responses0.00.00.0-0.1-0.0-0.1-0.1-0.1-0.10.2-0.10.20.20.20.0
Incentive Sensitization - Breakpoint0.00.00.0-0.00.0-0.0-0.0-0.0-0.00.10.00.10.10.1-0.0
Sum of active levers in priming session hrs 5-60.20.20.7-0.4-0.5-0.4-0.3-0.4-0.40.4-0.40.40.40.40.8
Progressive ratio0.40.50.50.70.70.70.70.70.7-0.70.7-0.7-0.6-0.7-0.5
Food seeking constrained by brief footshock1.62.02.51.41.51.51.51.51.6-1.31.4-1.4-1.3-1.4-0.9
Seeking ratio, punishment vs. effort0.10.10.10.20.30.30.30.30.3-0.20.2-0.2-0.2-0.20.1
Retroperitoneal fat weight0.20.60.9-0.9-0.7-0.8-0.9-0.8-0.80.8-0.70.80.90.80.1
Reaction time number correct2.94.14.82.22.22.12.12.02.0-2.12.1-2.0-2.0-2.0-1.6
Reaction time mean minus median0.10.20.3-0.4-0.3-0.4-0.5-0.4-0.30.4-0.40.40.40.4-0.5
Reaction time mean minus median AUC0.10.10.2-0.4-0.3-0.4-0.5-0.3-0.30.4-0.40.40.40.4-0.3
Reaction time num false alarms0.81.01.51.21.11.11.11.01.0-1.01.1-1.0-0.9-1.0-0.8
Reaction time num false alarms AUC1.31.72.21.51.41.41.31.31.3-1.41.3-1.3-1.2-1.3-1.1
Reaction time trials correct on left2.94.14.82.22.22.12.12.02.0-2.12.1-2.0-2.0-2.0-1.6
Reaction time trials on left2.94.14.82.22.22.02.12.02.0-2.02.1-2.0-2.0-2.0-1.6
Reaction time mean0.81.21.5-1.2-1.2-1.1-1.1-1.1-1.11.1-1.01.01.11.00.8
Reaction time mean AUC0.60.81.0-1.0-1.0-0.9-0.9-0.9-0.90.9-0.80.90.90.80.5
Median of all reaction times0.60.81.1-0.9-1.0-0.9-0.8-0.9-0.90.9-0.70.80.90.70.9
Reaction time omissions1.01.32.01.01.11.11.11.11.2-1.11.2-1.2-1.1-1.2-1.4
Reaction time false alarm rate0.10.10.20.40.30.30.30.30.3-0.30.3-0.2-0.2-0.2-0.4
Reaction time premature initiation rate0.81.01.21.01.01.01.11.01.0-1.11.1-1.0-1.0-1.0-0.8
Reaction time premature initiations2.43.43.81.91.91.82.01.81.8-2.01.9-1.9-1.9-1.9-1.3
Std. dev. reaction times0.30.40.7-0.8-0.7-0.7-0.8-0.7-0.60.7-0.70.70.60.7-0.2
Reaction time trials completed2.94.14.82.22.22.02.12.02.0-2.02.1-2.0-2.0-2.0-1.6
Reaction time trials AUC3.14.45.22.32.32.12.22.12.0-2.12.2-2.1-2.0-2.1-1.6
Run reversals in cocaine runway, females1.11.11.2-1.1-1.0-1.0-1.0-1.0-1.11.1-0.91.11.11.00.9
Run reversals in cocaine runway, males1.11.12.01.00.91.01.01.01.0-1.21.0-1.2-1.4-1.1-0.6
Latency to leave start box in cocaine runway0.10.10.2-0.2-0.3-0.4-0.3-0.4-0.40.2-0.30.10.20.10.3
Latency to leave start box in cocaine runway, F0.10.10.2-0.2-0.3-0.4-0.3-0.4-0.50.2-0.20.20.20.20.4
Latency to leave start box in cocaine runway, M0.10.10.1-0.2-0.3-0.3-0.3-0.3-0.30.1-0.30.10.10.10.2
Std. dev. time between licks in bursts0.81.01.3-1.0-1.0-0.9-0.9-0.9-0.90.9-1.01.00.91.01.1
Total sessions with >9 infusions0.20.21.8-0.1-0.3-0.3-0.1-0.3-0.30.2-0.40.20.20.21.4
Short access day 1 total inactive lever presses0.10.10.4-0.2-0.2-0.3-0.2-0.3-0.30.3-0.20.30.40.30.6
Short access day 10 total inactive lever presses0.40.41.00.60.70.70.60.70.7-0.50.7-0.5-0.6-0.5-1.0
Short access day 1 total infusions0.20.20.30.50.50.50.50.50.4-0.50.5-0.5-0.4-0.5-0.1
Short access day 10 total infusions0.50.50.7-0.6-0.6-0.7-0.7-0.7-0.70.8-0.70.80.80.80.5
Short access total infusions0.30.30.6-0.5-0.5-0.5-0.5-0.5-0.50.5-0.60.50.50.50.8
Short access day 1 locomotion0.80.91.5-0.8-0.9-0.9-0.9-0.9-1.00.9-0.90.91.00.91.2
Short access day 10 total locomotion0.70.81.1-0.8-0.9-0.8-0.8-0.9-0.90.9-0.90.90.90.91.1
Short access total locomotion0.10.10.4-0.2-0.3-0.3-0.3-0.3-0.30.3-0.40.30.30.30.6
One hour access (0.3 mA shock)0.00.00.10.30.30.30.30.20.2-0.10.2-0.1-0.2-0.10.1
Compulsive drug intake0.00.00.0-0.2-0.1-0.1-0.1-0.1-0.10.2-0.00.20.20.20.0
One hour access (shock baseline)0.00.10.3-0.1-0.1-0.2-0.1-0.2-0.20.2-0.30.20.10.20.5
Social response proportion0.30.30.30.50.60.50.50.50.5-0.50.6-0.5-0.5-0.5-0.5
Social responses0.10.10.3-0.3-0.3-0.3-0.2-0.3-0.30.2-0.20.20.20.20.5
Social time0.91.21.70.91.01.01.01.01.0-1.21.1-1.2-1.1-1.1-1.3
Soleus weight0.00.10.3-0.2-0.2-0.2-0.1-0.2-0.20.0-0.20.20.00.30.6
Bone: stiffness1.62.53.01.51.61.71.61.71.7-1.61.5-1.6-1.6-1.5-1.4
Tibialis anterior weight0.31.01.51.01.11.01.01.01.0-1.10.9-1.0-1.2-0.9-1.0
Time to tail flick, vehicle, before self-admin0.60.60.90.70.80.80.70.80.8-0.70.8-0.7-0.8-0.7-0.9
Time to tail flick, vehicle, after self-admin0.20.20.5-0.3-0.4-0.5-0.4-0.5-0.50.4-0.50.40.40.40.7
Time to tail flick, test, before self-admin0.10.10.10.30.20.20.30.20.2-0.30.2-0.3-0.3-0.30.3
Time to tail flick, test, after self-admin1.81.92.31.41.41.41.31.41.4-1.31.4-1.4-1.3-1.4-1.5
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.2-0.3-0.3-0.2-0.3-0.40.3-0.30.30.30.30.8
Delta time to tail flick, test, before/after SA1.11.02.01.01.01.00.91.01.0-0.91.0-0.9-0.9-0.9-1.4
Tibia length0.51.42.01.01.11.11.01.21.2-1.41.0-1.2-1.4-1.2-1.4
Ambulatory time before self-admin0.10.10.2-0.1-0.2-0.3-0.4-0.3-0.30.4-0.30.40.40.4-0.1
Ambulatory time after self-admin0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.10.10.10.10.3
Bone: tissue strength0.10.10.40.20.40.40.30.40.4-0.30.3-0.2-0.3-0.2-0.6
Total heroin consumption1.21.41.61.21.11.21.21.21.2-1.21.2-1.3-1.2-1.3-0.8
Bone: trabecular number0.00.00.10.20.20.20.30.20.1-0.10.3-0.2-0.1-0.20.1
Bone: trabecular spacing0.00.10.1-0.3-0.3-0.2-0.4-0.2-0.10.2-0.40.20.20.2-0.2
Bone: trabecular thickness0.10.10.20.30.30.40.40.30.3-0.40.4-0.4-0.4-0.4-0.0
Bone: trabecular tissue density0.20.30.50.70.70.50.70.50.5-0.40.7-0.6-0.4-0.6-0.3
Water consumed over 24 hours3.44.14.62.02.02.02.02.02.0-2.12.1-2.1-2.1-2.1-2.0
Number of responses in last shaping day0.30.30.5-0.7-0.7-0.6-0.7-0.6-0.60.5-0.60.50.50.50.1