Hub : Genes

Eif2ak4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Eif2ak4 0.06 0.03 2.7e-10 0.04 0.06 0.07 0.07 4.3e-06 4.5e-09 1.8e-10 2.6e-10
2 Brain mRNA stability Eif2ak4 0.05 0.03 7.6e-05 0.03 0.04 0.03 0.04 6.0e-04 7.1e-05 2.1e-03 3.0e-04
3 NAcc intron excision ratio chr3_125821191_125825289 0.07 0.04 5.0e-09 0.06 0.06 0.04 0.05 8.8e-09 4.0e-09 3.6e-07 2.0e-08
4 IC gene expression Eif2ak4 0.21 0.1 9.0e-06 0.09 0.1 0.11 0.08 1.7e-04 8.2e-05 3.2e-05 2.8e-04
5 PL mRNA stability Eif2ak4 0.07 0.03 3.2e-08 0.07 0.08 0.07 0.08 8.0e-08 8.0e-09 1.3e-08 1.1e-08
6 NAcc gene expression Eif2ak4 0.3 0.09 0.0e+00 0.2 0.26 0.26 0.26 3.5e-29 6.5e-39 9.0e-39 7.2e-39
7 PL gene expression Eif2ak4 0.13 0.06 1.1e-13 0.11 0.13 0.13 0.13 1.2e-11 4.4e-14 1.1e-13 1.4e-13
8 NAcc intron excision ratio chr3_125793492_125804956 0.31 0.08 0.0e+00 0.36 0.35 0.36 0.36 1.0e-57 8.4e-55 4.4e-58 7.6e-57
9 NAcc intron excision ratio chr3_125810442_125821079 0.04 0.02 5.3e-07 0.05 0.05 0.04 0.05 5.7e-08 4.0e-08 3.1e-06 6.7e-08
10 pVTA gene expression Eif2ak4 0.19 0.09 4.0e-12 0.18 0.17 0.16 0.17 3.0e-14 2.2e-13 3.7e-13 5.9e-14
11 Adipose mRNA stability Eif2ak4 0.06 0.03 4.0e-05 0.01 0.03 0.02 0.01 3.0e-02 5.7e-04 6.5e-03 1.0e-02
12 Brain gene expression Eif2ak4 0.14 0.07 5.4e-12 0.13 0.11 0.12 0.03 3.4e-12 1.0e-10 1.0e-11 5.9e-04
13 BLA gene expression Eif2ak4 0.14 0.09 1.5e-03 0.02 0 0.03 0.03 2.3e-02 2.5e-01 1.7e-02 1.6e-02
14 Liver gene expression Eif2ak4 0.26 0.11 0.0e+00 0.13 0.14 0.14 0.14 1.0e-14 1.2e-15 5.9e-15 8.0e-15
15 OFC gene expression Eif2ak4 0.35 0.16 8.0e-04 0.03 0.07 0.05 0.05 5.8e-02 1.0e-02 2.1e-02 3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.71.22.01.21.2-1.41.41.21.21.41.2-1.21.2-0.61.20.60.20.6
Area under the delay curve2.02.36.72.01.6-1.61.12.60.30.81.2-1.30.2-1.8-0.1-1.9-2.0-1.8
BMI with tail2.89.621.34.64.6-3.43.93.63.93.23.0-2.53.1-0.53.01.50.30.6
BMI without tail4.814.826.25.15.1-4.24.13.94.94.24.0-3.74.0-0.74.62.41.02.2
Body weight3.013.028.35.35.2-4.14.74.34.43.73.4-2.83.5-0.53.61.80.30.6
Weight adjusted by age0.30.41.81.31.1-0.60.71.00.70.30.5-0.10.1-0.1-0.1-0.1-0.7-0.7
Bone surface0.81.42.70.91.2-0.91.60.51.61.30.8-0.71.60.21.41.41.21.3
Bone volume0.91.73.21.21.5-1.11.80.81.71.50.8-0.91.80.11.51.31.11.0
Breakpoint value in progressive ratio session0.00.10.2-0.10.1-0.10.10.1-0.10.20.0-0.30.2-0.30.5-0.20.20.3
Number of licking bursts0.10.20.6-0.6-0.3-0.40.4-0.2-0.00.60.1-0.40.8-0.30.50.40.70.7
Context. condit. distance diff. score2.12.54.71.21.5-1.51.50.82.01.91.4-1.42.2-0.02.01.91.41.8
Locomotion velocity, session 12.93.17.4-1.9-2.31.2-1.6-0.8-2.7-1.8-1.10.9-2.4-0.8-2.0-2.1-1.6-1.6
Locomotion distance, session 11.41.74.0-1.5-1.80.9-1.4-0.7-2.0-1.4-0.40.5-1.9-0.7-1.4-1.5-1.4-0.7
Locomotion velocity, session 21.41.64.60.90.6-1.60.71.9-0.10.81.8-1.7-0.2-2.10.3-1.4-1.8-0.4
Locomotion distance, session 20.40.61.5-1.2-1.20.3-0.9-0.5-1.0-0.50.3-0.2-0.9-0.8-0.3-0.7-0.70.5
Locomotion velocity, session 30.60.62.40.40.4-0.70.31.1-0.10.50.7-0.80.1-1.5-0.5-1.3-1.1-0.7
Locomotion distance, session 31.01.12.40.20.7-1.00.90.51.11.41.2-1.21.5-0.91.20.60.61.6
Stereotopy head waving bouts, day 31.31.54.82.21.9-1.31.81.91.21.10.5-0.70.6-0.40.4-0.4-0.4-1.4
Stereotopy head waving duration, day 31.82.16.12.31.8-1.61.62.50.81.01.0-1.10.3-1.30.2-1.1-1.4-1.8
Locomotion velocity, session 70.80.91.50.80.9-1.10.90.81.01.21.1-1.11.1-0.61.20.60.40.8
Locomotion distance, session 70.60.82.8-0.20.1-0.3-0.0-0.50.80.70.4-0.41.00.41.31.51.31.7
Stereotopy head waving bouts, day 70.30.31.4-0.0-0.10.50.2-0.1-0.4-0.4-1.00.7-0.40.3-0.9-0.5-0.1-1.2
Stereotopy head waving duration, day 70.30.41.70.20.20.60.4-0.0-0.1-0.4-1.10.9-0.20.6-0.8-0.40.1-1.3
Locomotion velocity, session 81.61.94.11.51.3-1.91.12.00.91.42.0-1.80.9-1.70.8-0.4-1.0-0.0
Locomotion distance, session 80.81.22.90.40.5-1.20.80.51.01.31.6-1.41.1-0.71.51.00.51.7
Degree of sensitization distance1.11.12.9-0.8-0.91.3-0.9-1.5-0.4-1.0-1.41.4-0.61.7-0.30.81.0-0.1
Degree of sensitization stereotypy0.50.61.9-0.4-0.30.90.0-0.9-0.1-0.5-1.41.2-0.11.2-0.50.40.9-0.4
Conditioned locomotion1.51.73.01.41.4-1.61.41.21.61.71.1-1.31.5-0.31.71.10.80.8
Cocaine response after cond. corrected0.30.42.1-0.8-0.6-0.3-0.60.1-0.50.40.3-0.70.3-1.4-0.3-0.8-0.40.2
Cocaine response after cond. not corrected0.50.62.5-1.1-1.0-0.1-0.90.0-0.90.00.3-0.6-0.2-1.6-0.7-1.1-0.80.0
Cocaine response before conditioning0.50.61.7-0.6-0.80.5-0.7-0.3-1.1-1.1-0.10.4-1.3-0.1-1.0-0.8-1.1-0.5
Saline control response0.60.72.21.51.2-0.11.20.60.80.1-0.70.70.21.40.40.60.5-1.2
Bone: connectivity density0.10.10.40.60.40.00.60.20.2-0.1-0.30.3-0.10.6-0.10.20.1-0.5
Bone: cortical apparent density1.01.44.3-1.1-0.61.1-0.4-1.80.3-0.3-1.41.20.61.80.41.52.11.0
Bone: cortical area1.11.73.41.81.9-1.41.81.51.61.31.4-1.11.3-0.41.20.50.00.5
Bone: cortical porosity1.61.86.9-0.4-0.7-0.9-1.01.0-1.30.11.5-1.5-0.8-2.6-0.5-1.9-2.2-0.2
Bone: cortical porosity1.21.45.10.30.1-1.2-0.21.4-0.60.41.6-1.5-0.4-2.3-0.2-1.5-2.0-0.3
Bone: cortical thickness0.81.32.61.61.5-1.41.31.61.01.11.5-1.30.8-0.90.9-0.1-0.60.2
Bone: cortical thickness0.30.41.20.00.3-0.80.30.40.41.00.5-0.71.1-0.70.70.30.50.6
Bone: cortical tissue density0.91.33.8-1.1-0.61.1-0.4-1.70.2-0.3-1.41.20.51.70.31.42.00.9
Condit. Reinf. active minus inactive responses1.61.86.1-0.7-0.71.70.1-1.6-0.4-1.4-2.02.2-0.72.5-0.50.91.2-0.7
Condit. Reinf. active-inactive response ratio0.40.41.60.60.60.30.8-0.10.5-0.2-0.60.80.31.30.20.70.6-0.5
Condit. Reinf. active responses3.13.810.9-1.5-1.42.5-0.1-2.6-0.9-1.9-3.03.0-1.13.3-0.61.21.8-0.6
Condit. Reinf. inactive responses2.02.45.5-1.8-1.61.9-0.4-2.3-0.8-1.3-2.22.0-0.82.2-0.31.01.60.3
Incentive salience index mean2.83.47.9-1.6-1.62.4-0.5-2.4-1.4-2.3-2.62.8-1.62.7-1.00.50.9-0.8
Condit. Reinf. lever presses2.53.67.1-1.9-1.92.5-0.8-2.4-1.8-2.5-2.42.7-1.92.4-1.10.10.5-0.9
Condit. Reinf. active minus inactive responses0.91.25.00.30.50.60.9-0.90.9-0.0-1.01.10.62.20.61.91.90.4
Condit. Reinf. active-inactive response ratio0.70.92.80.30.60.40.8-0.71.00.1-0.50.70.81.70.71.61.50.8
Condit. Reinf. active responses1.21.76.80.60.80.51.4-0.71.20.1-1.21.20.82.60.72.12.10.2
Condit. Reinf. inactive responses0.60.83.40.70.70.41.3-0.20.6-0.2-1.21.20.11.8-0.00.81.0-0.8
Condit. Reinf. lever presses0.91.24.81.00.90.61.6-0.10.5-0.5-1.51.6-0.12.20.00.70.9-1.5
Condit. Reinf. lever reinforcers received1.31.88.40.50.60.91.2-1.00.9-0.4-1.61.70.32.90.31.92.0-0.2
Conditioned reinforcement - actives0.30.51.3-0.2-0.50.1-0.70.2-0.9-0.5-0.10.0-0.9-0.7-0.6-1.1-1.2-0.9
Conditioned reinforcement - inactives0.30.51.10.40.5-0.90.30.60.51.10.8-1.00.8-0.61.00.40.40.6
Conditioned locomotion1.01.34.90.2-0.30.4-0.50.5-1.2-1.2-0.50.7-1.5-0.4-1.2-1.8-1.9-2.2
Patch foraging indifference point 0 sec0.81.56.12.01.50.01.31.40.4-0.6-0.30.8-0.90.6-1.0-1.2-1.4-2.5
Patch foraging indifference point AUC1.01.42.7-1.5-1.61.1-1.0-1.0-1.6-1.2-1.41.2-1.30.1-1.4-0.8-0.5-0.8
Delay disc. indifference point, 0s delay0.90.93.90.50.20.5-0.30.6-0.6-0.9-0.50.7-1.1-0.1-1.3-1.6-1.4-2.0
Delay disc. indifference point, 16s delay1.31.43.90.90.7-1.10.41.8-0.40.40.8-0.9-0.1-1.9-0.5-2.0-1.9-1.6
Delay disc. indifference point, 2s delay0.60.71.71.31.3-0.61.30.71.20.70.5-0.30.70.50.80.80.50.2
Delay disc. indifference point, 24s delay1.41.63.1-0.9-1.11.0-1.2-0.4-1.8-1.4-1.00.8-1.6-0.3-1.6-1.7-1.2-1.7
Delay disc. indifference point, 4s delay0.90.92.51.10.8-1.00.41.6-0.10.40.8-0.9-0.2-1.2-0.1-1.3-1.3-1.2
Delay disc. indifference point, 8s delay3.23.810.62.92.5-2.11.93.31.01.31.7-1.70.7-2.00.3-1.8-2.0-1.8
Indifference point function ln k2.54.47.22.22.5-2.31.81.92.62.42.7-2.42.3-0.92.61.10.51.9
Indifference point function log k2.54.47.22.22.5-2.31.81.92.62.42.7-2.42.3-0.92.61.10.51.9
Patch foraging total patch changes 0 sec0.71.35.41.91.50.01.41.30.4-0.5-0.40.8-0.70.6-1.0-1.1-1.2-2.3
Patch foraging total patch changes 12 sec0.71.02.3-0.1-0.41.00.1-0.3-0.6-1.3-1.11.4-1.40.7-1.5-0.7-0.8-1.4
Patch foraging total patch changes 18 sec0.61.02.8-0.6-0.80.9-0.4-0.5-1.0-1.2-1.21.3-1.20.4-1.7-0.7-0.7-1.3
Patch foraging total patch changes 24 sec0.50.93.41.40.9-0.70.71.50.00.00.2-0.0-0.3-0.5-0.7-1.0-1.3-1.8
Patch foraging total patch changes 6 sec0.40.72.10.2-0.10.8-0.1-0.0-0.6-1.0-1.01.1-1.10.6-1.1-0.9-0.7-1.5
Patch foraging time to switch 0 sec1.02.14.7-0.9-1.01.9-1.4-1.5-0.9-1.9-1.92.2-1.51.7-1.7-0.10.0-1.2
Patch foraging water rate 0 sec1.02.04.31.21.5-1.31.90.91.61.80.9-1.12.1-0.02.11.31.31.1
Patch foraging water rate 12 sec0.91.84.00.20.6-1.40.80.51.11.91.3-1.71.9-0.91.91.11.22.0
Patch foraging water rate 18 sec1.11.74.11.01.2-1.60.91.40.81.61.7-2.01.4-1.51.2-0.3-0.11.0
Patch foraging water rate 24 sec2.13.07.30.61.4-0.91.70.12.01.90.8-1.12.50.62.72.12.42.3
Patch foraging water rate 6 sec0.71.03.4-1.0-0.4-0.20.6-0.80.30.90.1-0.51.40.11.31.21.71.9
Seeking ratio, delayed vs. immediate footshock0.70.93.50.20.4-0.50.6-0.20.90.80.4-0.41.10.61.21.91.41.4
Distance traveled before self-admin0.50.71.61.01.0-1.01.11.30.30.70.9-1.00.2-0.70.8-0.6-0.6-0.4
Distance traveled after self-admin0.10.21.50.30.5-0.21.20.30.30.20.0-0.10.30.10.60.10.10.2
Extensor digitorum longus weight0.31.22.21.31.4-1.30.91.51.11.21.4-1.41.0-1.20.8-0.2-0.50.4
Bone: elastic displacement0.20.20.70.20.10.10.30.3-0.3-0.40.00.1-0.6-0.3-0.4-0.8-0.8-0.7
Bone: elastic work0.40.52.21.21.1-0.31.50.80.70.30.10.10.30.30.3-0.1-0.1-0.6
Bone: endosteal estimation0.30.71.60.20.5-0.70.70.20.91.10.7-0.81.3-0.31.01.00.91.2
Bone: endosteal perimeter0.10.20.90.10.3-0.20.3-0.10.60.50.5-0.40.7-0.00.60.60.50.9
Epididymis fat weight0.51.74.31.41.1-1.50.41.80.50.92.1-1.80.3-1.90.6-1.0-1.60.2
Delta time in closed arm before/after self-admin0.60.62.3-0.10.10.1-0.5-0.60.70.40.3-0.40.60.51.21.21.21.5
Delta time in open arm before/after self-admin2.72.75.11.21.4-2.02.21.21.72.21.1-1.42.3-0.32.01.71.31.1
Diff in mean of infusions in LGA sessions0.70.92.4-0.3-0.31.4-1.0-1.0-0.5-1.1-1.51.2-0.81.5-0.2-0.00.7-0.7
Delay discount exponential model param1.71.95.4-1.8-1.41.5-0.9-2.3-0.2-0.8-1.21.3-0.11.70.01.71.81.6
Extinction: sum of active levers before priming0.80.92.2-0.9-0.80.8-1.5-0.3-1.3-1.0-0.50.4-1.2-0.4-1.0-1.4-0.9-0.8
Active lever presses in extinction session 60.80.82.8-0.1-0.4-0.1-0.60.6-1.1-0.40.4-0.3-1.0-1.3-0.7-1.6-1.7-1.1
Bone: final force1.32.14.51.21.6-1.02.10.52.01.41.0-0.81.80.61.91.81.41.6
Bone: final moment1.32.04.01.21.6-1.02.00.62.01.41.0-0.81.80.51.81.71.31.6
Food consumed during 24 hour testing period0.10.20.6-0.5-0.3-0.40.3-0.1-0.20.40.3-0.50.3-0.40.40.30.20.8
Glucose2.03.14.81.61.9-1.81.91.42.12.02.0-1.92.1-0.82.21.20.61.8
Heart weight2.13.35.92.42.3-2.22.22.02.12.02.0-1.71.8-0.61.71.10.10.7
Delay discount hyperbolic model param1.51.74.8-1.8-1.41.4-1.1-2.2-0.4-0.8-1.11.2-0.21.4-0.11.41.51.4
Intermittent access intake day 1-15 change1.53.26.50.81.2-2.51.81.61.72.62.0-2.12.2-1.61.61.40.51.8
Intermittent access intake escalation1.63.36.61.11.4-2.62.11.81.92.61.9-2.02.3-1.51.51.30.41.6
Intermittent access intake escalation 22.52.96.70.30.6-2.61.31.70.92.52.1-2.51.8-2.51.20.5-0.11.6
Intermitt. access day 1 inactive lever presses0.10.52.31.21.0-0.10.10.21.00.30.4-0.40.20.81.50.70.60.5
Intermitt. access day 15 inactive lever presses0.40.92.10.70.8-0.80.20.31.31.11.1-1.01.1-0.11.31.10.81.4
Intermitt. access escalation Index0.60.93.70.50.70.70.6-0.71.0-0.1-0.71.00.61.90.71.51.50.4
Intermittent access day 1 total infusions0.40.61.70.0-0.20.6-0.70.0-0.8-0.9-0.60.5-1.00.0-0.8-1.2-0.8-1.3
Intermittent access day 15 total infusions0.50.81.70.91.0-1.30.91.11.11.30.8-0.91.1-0.60.90.60.20.3
Intermittent access terminal intake (last 3 days)1.11.53.10.81.0-1.71.11.31.11.81.4-1.61.4-1.21.20.60.21.0
Intermittent access total infusions0.10.20.40.50.4-0.70.20.70.40.60.4-0.50.4-0.50.1-0.0-0.2-0.0
Intermittent access day 1 locomotion0.60.72.51.00.6-0.1-0.11.0-0.3-0.50.3-0.0-0.9-0.5-0.5-1.5-1.6-1.5
Intermittent access day 15 total locomotion0.91.63.41.11.1-1.81.21.41.11.71.4-1.51.5-1.01.50.70.20.6
Intermittent access total locomotion0.30.41.10.70.5-0.90.31.10.00.40.6-0.60.1-0.9-0.1-0.5-0.9-0.7
Intermittent access standard deviation0.91.94.00.30.5-2.01.11.21.21.91.8-1.81.5-1.80.90.7-0.01.6
Left kidney weight1.77.814.73.83.3-3.73.03.82.52.83.6-3.22.0-1.92.80.6-1.10.4
Right kidney weight2.511.323.74.94.1-4.53.74.83.03.24.3-3.72.1-2.52.70.2-1.9-0.0
Cocaine induced anxiety0.30.41.40.90.40.1-0.90.30.2-0.50.9-0.3-0.8-0.20.0-0.6-1.2-0.4
Post-drug Anxiety0.40.41.31.00.6-0.3-0.70.20.90.21.1-0.70.0-0.00.90.5-0.20.8
Baseline Anxiety0.30.41.3-0.00.1-0.20.3-0.30.60.6-0.1-0.20.70.50.71.11.20.8
Tail length1.97.512.02.93.0-3.13.02.33.33.23.0-2.83.0-0.83.52.21.02.4
Length with tail0.93.87.82.52.5-2.32.82.12.32.11.9-1.61.9-0.42.11.30.40.8
Length without tail0.51.55.21.51.6-1.52.31.71.01.31.2-0.91.2-0.60.80.3-0.2-0.2
Times rat made contact with spout0.10.20.90.20.10.20.10.2-0.2-0.3-0.60.4-0.30.1-0.6-0.5-0.3-1.0
Lifetime Intake0.10.20.50.30.3-0.50.00.7-0.10.30.3-0.40.0-0.7-0.2-0.6-0.6-0.4
Liver weight, left2.64.311.92.82.9-2.13.52.02.42.11.4-1.31.90.42.61.61.00.6
Liver weight, right1.42.45.72.42.3-1.82.32.11.71.61.2-1.11.3-0.31.40.3-0.1-0.5
Locomotor activity0.30.51.0-0.7-0.80.7-1.0-0.6-1.0-0.9-0.30.3-1.0-0.0-0.6-0.7-0.5-0.2
Locomotor testing distance0.30.61.3-0.9-0.91.0-1.1-0.8-1.0-1.0-0.30.4-1.00.1-0.5-0.7-0.4-0.0
Locomotor testing rearing0.91.84.3-2.0-1.91.8-1.7-2.1-1.3-1.5-1.11.1-1.20.9-0.60.10.40.6
Locomotion in novel chamber0.20.20.70.60.80.1-0.00.10.80.10.6-0.30.30.10.50.00.10.8
Locomotion in novel chamber post-restriction1.22.03.41.51.5-1.81.81.31.71.81.2-1.31.9-0.51.41.30.50.8
Fecal boli incidents, locomotor time 10.40.61.6-0.6-0.70.3-1.3-0.0-0.8-0.40.1-0.1-0.5-1.0-1.0-1.3-1.1-0.4
Change in fecal boli incidents, locomotor task2.02.03.41.41.6-1.41.81.01.71.51.4-1.31.4-0.11.81.30.71.4
Time >=10cm from walls, locomotor time 10.30.31.1-0.10.0-0.20.3-0.20.40.7-0.3-0.20.70.20.70.81.10.6
Bouts of movement, locomotor time 13.43.87.0-2.5-2.61.8-2.2-1.6-2.6-2.0-1.71.5-2.1-0.3-2.4-1.9-1.1-1.4
Total resting periods, locomotor time 13.64.07.3-2.6-2.72.1-2.5-2.0-2.5-2.2-1.91.7-2.10.1-2.3-1.5-0.7-1.1
Rest time, locomotor task time 10.20.20.5-0.5-0.50.6-0.2-0.7-0.3-0.6-0.60.7-0.50.5-0.70.10.10.0
Distance moved, locomotor task time 10.10.20.8-0.00.00.40.4-0.2-0.2-0.3-0.90.7-0.20.6-0.3-0.10.3-0.8
Vertical activity count, locomotor time 10.10.41.30.30.5-0.21.2-0.00.70.5-0.10.00.60.50.70.80.90.4
Time >=10cm from walls, locomotor time 22.53.710.43.22.9-2.02.52.02.61.90.8-0.91.80.62.01.70.7-0.1
Bouts of movement, locomotor time 20.20.41.10.20.50.20.9-0.20.40.2-0.90.50.60.90.30.61.1-0.2
Total resting periods, locomotor time 20.20.31.00.10.40.30.9-0.30.40.1-0.80.60.50.90.20.71.0-0.0
Rest time, locomotor task time 22.12.76.0-2.5-2.51.7-2.0-1.8-2.1-1.8-1.01.2-1.8-0.1-1.7-1.0-0.7-0.0
Distance moved, locomotor task time 20.70.83.01.71.6-0.61.11.01.10.70.1-0.20.50.70.80.50.4-0.6
Vertical activity count, locomotor time 21.92.66.02.12.3-1.02.50.92.21.50.4-0.41.61.21.91.81.60.7
Light reinforcement 11.33.19.90.60.22.00.2-1.0-0.2-2.0-2.73.0-1.53.1-1.60.30.4-2.3
Light reinforcement 21.11.72.8-1.4-1.41.7-0.7-1.5-1.4-1.6-1.71.6-1.61.0-1.1-0.50.0-0.7
Bone: marrow area0.30.71.50.20.5-0.80.70.20.91.10.8-0.81.2-0.31.00.90.81.1
Bone: maximum diameter0.61.02.41.31.4-0.71.50.61.61.00.8-0.51.30.31.01.00.70.8
Bone: maximum force1.22.14.21.92.0-1.42.11.21.91.41.2-0.91.50.31.61.30.70.9
Bone: maximum moment1.01.83.61.81.9-1.31.81.21.81.31.2-0.91.40.21.51.10.60.9
Mean time between licks in bursts0.20.61.7-0.8-0.8-0.2-0.80.2-1.1-0.20.3-0.6-0.7-1.3-0.5-1.1-1.1-0.1
Mean num. licks in bursts0.20.20.80.70.40.4-0.10.20.1-0.5-0.40.6-0.60.6-0.5-0.3-0.4-0.9
Cd content in liver0.20.20.70.70.8-0.40.40.50.80.60.2-0.30.70.00.40.30.30.1
Co content in liver0.60.72.90.50.4-0.8-0.71.10.10.50.9-1.00.1-1.7-0.5-1.2-1.3-0.3
Cu content in liver0.30.31.5-0.8-0.5-0.2-0.1-0.50.10.50.3-0.40.7-0.20.40.70.71.2
Fe content in liver2.53.17.4-1.8-1.32.2-0.7-2.7-0.3-1.2-2.32.3-0.22.7-0.21.62.30.7
K content in liver0.50.50.90.30.5-0.80.30.40.70.90.8-0.80.9-0.30.80.60.50.9
Mg content in liver2.22.25.10.91.4-1.61.40.91.82.11.4-1.52.3-0.61.71.31.11.5
Mn content in liver0.91.02.91.71.6-1.21.31.31.21.10.7-0.70.9-0.01.00.50.2-0.3
Na content in liver0.40.51.5-1.2-1.10.5-1.0-1.0-0.5-0.3-0.30.2-0.20.30.10.50.60.8
Rb content in liver3.33.86.02.52.4-2.52.02.52.22.32.3-2.22.0-1.41.60.4-0.30.6
Se content in liver0.30.31.00.40.5-0.50.50.20.70.7-0.2-0.10.90.50.70.81.00.1
Sr content in liver0.20.20.7-0.1-0.3-0.1-0.00.3-0.6-0.20.2-0.3-0.7-0.7-0.3-0.8-0.8-0.4
Zn content in liver0.91.03.9-1.2-0.70.3-0.4-1.30.50.3-0.20.10.90.70.71.51.62.0
Bone: minimum diameter0.91.74.11.91.6-1.50.92.00.91.01.7-1.30.5-1.40.3-0.8-1.3-0.5
Time in familiar zone, hab. session 10.70.72.0-1.4-1.40.8-1.3-0.9-1.1-0.7-0.70.4-0.7-0.3-0.8-0.6-0.2-0.0
Time in novel zone, hab. session 11.41.43.51.91.9-1.01.51.11.81.10.7-0.51.20.51.01.10.60.2
Total zone transitions, hab. session 10.91.22.6-1.1-1.40.8-1.5-0.5-1.6-1.2-0.40.4-1.5-0.5-1.2-1.3-1.2-0.7
Total locomotion distance, hab. session 10.91.22.6-1.0-1.40.9-1.3-0.6-1.6-1.4-0.40.6-1.6-0.3-1.3-1.2-1.2-0.8
Locomotion velocity, hab. session 11.52.14.5-1.3-1.71.3-1.5-0.9-2.1-1.8-0.70.9-2.1-0.3-1.6-1.6-1.5-1.1
Time in familiar zone, hab. session 20.10.10.5-0.00.10.30.5-0.20.30.1-0.60.40.40.5-0.00.30.7-0.2
Time in novel zone, hab. session 20.50.51.21.00.8-0.90.31.10.40.51.0-0.80.1-0.60.3-0.2-0.7-0.0
Total zone transitions, hab. session 20.30.41.0-0.6-0.7-0.2-0.40.1-1.0-0.30.6-0.5-0.8-1.0-0.1-0.8-1.00.1
Total locomotion distance, hab. session 20.10.10.5-0.2-0.40.3-0.0-0.2-0.6-0.6-0.20.3-0.70.2-0.1-0.2-0.3-0.3
Locomotion velocity, hab. session 20.20.31.0-0.5-0.70.6-0.3-0.5-0.9-0.8-0.40.5-1.00.3-0.3-0.3-0.4-0.3
Novel to familiar place preference ratio0.40.51.81.31.2-0.30.80.61.00.3-0.00.10.40.80.40.60.4-0.5
Novelty place preference0.40.41.71.31.2-0.30.70.61.00.30.10.10.30.60.30.40.3-0.5
Time in novel zone, NPP test0.40.41.71.31.2-0.30.70.51.00.4-0.00.10.40.80.40.60.4-0.5
Total zone transitions, NPP test0.71.02.5-1.5-1.60.0-1.2-0.3-1.6-0.40.6-0.6-0.9-1.6-0.6-1.1-1.10.3
Total locomotion distance, NPP test0.60.82.5-0.6-0.9-0.4-0.90.3-1.2-0.30.9-0.8-0.8-1.6-0.5-1.2-1.5-0.1
Locomotion velocity, NPP test0.71.03.1-0.7-1.0-0.3-1.00.4-1.3-0.31.0-0.9-1.0-1.8-0.6-1.4-1.7-0.1
Intraocular pressure0.91.33.0-0.9-0.91.4-0.9-0.6-1.4-1.4-0.91.0-1.4-0.1-1.7-1.6-1.0-1.1
Delta distance traveled before/after self-admin0.30.30.9-0.5-0.50.8-0.0-0.8-0.3-0.6-0.90.9-0.20.7-0.40.20.3-0.1
Delta ambulatory time before/after self-admin0.81.02.5-0.9-1.01.3-0.7-1.3-0.6-1.3-1.51.6-0.81.2-0.90.20.2-0.5
Parametrial fat weight0.20.62.00.1-0.30.9-0.7-0.4-0.6-1.3-0.20.6-1.40.5-0.7-0.7-0.9-0.6
Pavlov. Cond. lever latency0.91.12.81.11.5-0.91.00.81.71.50.5-0.81.5-0.20.80.71.00.7
Pavlov. Cond. magazine entry latency1.01.34.7-0.2-0.51.50.1-1.2-0.6-1.7-1.31.9-1.12.2-0.50.50.2-0.8
Pavlov. Cond. change in total contacts0.30.31.2-0.6-0.60.20.1-0.8-0.3-0.30.30.1-0.10.60.70.90.41.1
Pavlov. Cond. index score1.21.53.7-1.0-1.31.5-0.8-1.3-1.5-1.9-1.01.6-1.61.2-0.9-0.3-0.5-0.8
Pavlov. Cond. latency score1.31.64.1-0.9-1.31.5-0.8-1.1-1.6-2.0-1.01.6-1.81.1-1.1-0.6-0.8-1.1
Pavlov. Cond. lever contacts1.21.43.1-1.2-1.61.2-1.0-1.1-1.8-1.8-0.71.1-1.70.6-0.9-0.6-0.8-0.7
Pavlov. Cond. magazine entry number0.50.62.8-0.00.2-1.0-0.50.70.31.20.7-1.30.7-1.70.2-0.5-0.10.5
Pavlov. Cond. intertrial magazine entries0.50.61.8-0.20.3-0.40.7-0.10.91.10.1-0.41.3-0.10.90.81.31.0
Pavlov. Cond. lever-magazine prob. diff.1.11.33.2-1.1-1.41.4-0.8-1.2-1.5-1.8-0.81.3-1.50.9-0.9-0.4-0.6-0.6
Pavlov. Cond. response bias0.81.02.1-1.0-1.11.3-0.4-1.4-1.0-1.4-0.91.3-1.01.4-0.30.50.20.0
Pavlov. Cond. lever latency1.11.54.8-1.7-1.70.2-2.2-0.5-1.4-0.30.6-0.8-0.7-1.9-0.9-1.2-1.10.8
Pavlov. Cond. magazine entry latency1.31.57.30.50.60.91.1-0.90.9-0.4-1.61.70.32.70.41.61.8-0.4
Pavlov. Cond. change in total contacts0.91.46.00.50.70.61.5-0.81.0-0.1-1.01.20.62.50.81.91.80.4
Pavlov. Cond. index score1.52.07.71.01.20.52.0-0.51.40.1-1.21.30.82.81.12.02.10.1
Pavlov. Cond. latency score1.31.75.90.91.10.31.9-0.51.30.2-1.01.10.82.41.11.91.90.2
Pavlov. Cond. lever contacts1.31.75.31.71.70.12.20.41.40.2-1.01.20.72.30.71.31.3-1.0
Pavlov. Cond. magazine entry number1.21.56.5-0.6-0.8-0.6-1.30.8-1.10.01.2-1.3-0.7-2.5-0.7-1.9-2.0-0.1
Pavlov. Cond. intertrial magazine entries0.60.93.00.60.3-1.1-0.21.4-0.40.50.9-1.1-0.1-1.7-0.4-1.3-1.4-0.9
Pavlov. Cond. lever-magazine prob. diff.1.41.97.50.91.10.61.8-0.61.30.0-1.31.40.72.71.02.02.1-0.0
Pavlov. Cond. response bias1.82.58.91.61.80.32.4-0.11.70.2-1.31.51.03.01.02.02.0-0.7
Time in closed arm before self-admin1.72.14.3-1.7-1.71.9-0.9-1.8-1.5-1.6-2.11.8-1.21.2-1.3-0.30.5-0.6
Time in closed arm after self-admin1.81.94.8-1.4-1.31.9-0.9-2.2-0.6-1.2-1.81.6-0.71.9-0.50.91.50.4
Time in open arm before self-admin0.20.20.50.60.7-0.20.40.70.30.10.3-0.10.1-0.3-0.2-0.6-0.6-0.5
Time in open arm after self-admin3.53.87.21.82.0-2.72.22.31.82.62.1-2.32.3-1.42.00.70.30.8
Bone: periosteal estimation0.61.22.01.21.4-1.21.41.01.41.31.2-1.01.3-0.41.10.60.40.7
Bone: periosteal perimeter0.61.02.11.41.4-1.11.11.31.10.91.4-1.00.8-0.80.7-0.1-0.50.3
Bone: post-yield work0.30.41.4-0.4-0.3-0.6-0.60.2-0.20.41.1-1.10.2-1.00.50.1-0.31.2
Progressive ratio test 1 active lever presses0.10.20.4-0.3-0.20.6-0.4-0.4-0.2-0.4-0.60.6-0.30.6-0.0-0.10.2-0.4
Progressive ratio test 1 breakpoint0.10.20.3-0.3-0.20.6-0.5-0.4-0.3-0.4-0.60.5-0.40.5-0.0-0.10.2-0.4
Progressive ratio test 1 inactive lever presses0.20.20.6-0.3-0.20.6-0.8-0.70.1-0.3-0.30.3-0.10.70.50.50.60.5
Progressive ratio test 2 active lever presses0.10.10.50.10.30.20.2-0.10.30.1-0.50.40.30.70.20.60.7-0.2
Progressive ratio test 2 breakpoint0.20.20.50.30.50.00.50.00.50.3-0.40.30.40.70.20.70.7-0.1
Progressive ratio test 2 inactive lever presses0.10.20.30.50.5-0.40.10.30.60.50.4-0.40.50.10.40.50.30.3
Incentive Sensitization - Responses0.10.10.30.30.4-0.40.30.50.20.40.2-0.30.4-0.20.1-0.0-0.1-0.2
Incentive Sensitization - Breakpoint0.10.10.20.30.4-0.30.40.40.30.30.1-0.10.3-0.1-0.00.10.0-0.2
Sum of active levers in priming session hrs 5-60.20.20.7-0.4-0.4-0.6-0.60.1-0.10.60.5-0.70.4-0.80.30.20.10.7
Progressive ratio0.10.20.7-0.3-0.20.60.5-0.6-0.2-0.3-0.60.5-0.30.80.40.30.70.0
Food seeking constrained by brief footshock0.00.00.10.20.1-0.10.20.2-0.00.10.0-0.1-0.10.00.1-0.10.1-0.3
Seeking ratio, punishment vs. effort0.00.00.20.10.1-0.1-0.30.20.10.00.1-0.00.0-0.2-0.4-0.2-0.2-0.2
Retroperitoneal fat weight1.04.113.93.73.5-1.23.01.83.01.11.0-0.31.31.71.91.40.7-0.2
Reaction time number correct2.75.29.01.82.2-2.72.61.82.42.92.3-2.43.0-0.92.91.91.22.1
Reaction time mean minus median0.10.30.91.00.9-0.60.60.70.90.60.2-0.10.60.20.30.60.3-0.2
Reaction time mean minus median AUC0.61.53.81.91.9-1.41.21.41.71.31.0-0.71.30.01.00.90.30.0
Reaction time num false alarms0.00.00.00.1-0.0-0.10.20.0-0.1-0.10.1-0.0-0.10.0-0.10.1-0.1-0.1
Reaction time num false alarms AUC0.10.10.3-0.2-0.30.30.1-0.5-0.1-0.3-0.30.3-0.10.5-0.10.40.30.2
Reaction time trials correct on left2.75.29.01.82.2-2.72.61.82.42.92.3-2.43.0-0.92.91.91.22.1
Reaction time trials on left2.75.08.91.82.2-2.62.51.82.42.92.2-2.33.0-0.82.81.91.22.1
Reaction time mean0.71.12.9-0.9-0.61.2-0.2-1.5-0.1-0.6-1.71.4-0.01.7-0.21.01.50.1
Reaction time mean AUC0.40.62.0-0.5-0.20.9-0.1-1.00.1-0.3-1.31.10.21.40.00.91.30.2
Median of all reaction times1.42.04.9-1.6-1.31.9-0.7-2.1-0.8-1.2-2.21.9-0.51.9-0.50.81.60.1
Reaction time omissions0.30.42.00.70.40.10.20.20.2-0.3-0.81.0-0.11.0-0.70.40.1-1.4
Reaction time false alarm rate1.01.32.4-0.9-1.11.4-1.0-1.2-1.1-1.5-1.21.4-1.50.8-1.4-0.6-0.4-0.9
Reaction time premature initiation rate2.53.57.6-1.3-1.62.8-1.9-2.5-1.1-2.4-2.32.5-2.12.3-1.50.10.6-0.6
Reaction time premature initiations0.50.93.3-0.3-0.31.2-0.4-1.40.3-0.7-1.01.1-0.21.80.21.21.40.7
Std. dev. reaction times0.30.51.21.11.1-0.20.80.41.10.4-0.30.40.70.90.20.80.7-0.4
Reaction time trials completed2.75.08.91.82.2-2.62.51.82.42.92.2-2.33.0-0.82.81.91.22.1
Reaction time trials AUC2.75.19.61.72.1-2.42.61.52.52.92.0-2.13.1-0.52.92.21.62.3
Run reversals in cocaine runway, females1.01.03.0-0.10.1-1.0-0.00.40.51.01.7-1.60.7-1.21.40.50.01.7
Run reversals in cocaine runway, males0.10.10.3-0.6-0.60.3-0.2-0.4-0.5-0.3-0.10.2-0.2-0.0-0.3-0.10.00.1
Latency to leave start box in cocaine runway0.50.51.8-0.4-0.10.8-0.2-1.00.3-0.3-0.80.80.11.30.31.01.20.4
Latency to leave start box in cocaine runway, F0.20.31.1-0.6-0.60.5-1.1-0.5-0.5-0.5-0.50.3-0.60.1-0.6-0.4-0.1-0.2
Latency to leave start box in cocaine runway, M2.22.16.40.30.60.61.1-1.21.60.3-0.80.91.12.51.52.52.51.3
Std. dev. time between licks in bursts0.81.03.01.51.2-1.20.71.70.40.71.0-0.90.2-1.10.3-0.8-1.2-0.9
Total sessions with >9 infusions0.81.03.7-0.1-0.30.7-0.50.2-1.1-1.1-0.60.6-1.4-0.3-1.1-1.9-1.4-1.6
Short access day 1 total inactive lever presses1.01.33.11.20.8-1.4-0.01.60.50.81.7-1.40.3-1.8-0.1-0.8-1.5-0.0
Short access day 10 total inactive lever presses0.61.54.60.70.6-0.8-0.6-0.01.41.11.3-1.41.1-0.02.11.61.02.1
Short access day 1 total infusions0.60.83.6-0.1-0.30.2-0.90.4-1.2-0.6-0.1-0.1-1.1-0.9-0.7-1.9-1.3-1.2
Short access day 10 total infusions0.60.81.4-0.3-0.50.9-0.9-0.3-0.8-1.1-0.90.9-1.20.3-1.1-1.1-0.8-1.2
Short access total infusions0.40.52.3-0.1-0.20.4-0.30.3-0.8-0.6-0.30.3-0.8-0.5-0.9-1.5-1.1-1.2
Short access day 1 locomotion0.91.22.2-0.7-0.81.3-1.0-0.5-1.3-1.4-1.11.0-1.50.2-1.2-1.4-0.8-1.2
Short access day 10 total locomotion1.52.87.31.41.0-1.90.72.6-0.20.82.1-1.80.1-2.7-0.0-2.0-2.6-1.2
Short access total locomotion1.01.24.70.80.4-0.10.11.1-0.6-0.70.30.0-1.1-0.9-1.0-2.0-2.2-1.8
One hour access (0.3 mA shock)1.61.84.4-0.10.5-1.51.50.41.21.90.9-1.12.1-0.51.71.71.41.7
Compulsive drug intake0.91.02.6-0.30.2-1.11.50.30.91.31.1-0.91.6-0.80.71.10.51.6
One hour access (shock baseline)0.10.20.50.1-0.00.2-0.1-0.20.1-0.2-0.70.7-0.20.7-0.00.40.3-0.6
Social response proportion2.63.011.8-0.6-0.41.6-0.3-2.20.7-0.6-2.22.00.33.40.52.52.90.6
Social responses3.03.811.2-1.6-1.32.4-0.6-2.8-0.3-1.6-2.92.8-0.63.3-0.81.72.30.1
Social time0.50.72.7-0.10.30.50.7-0.81.00.2-0.80.70.71.40.41.21.70.8
Soleus weight0.20.51.3-0.5-0.30.9-0.3-1.00.2-0.3-0.90.90.41.10.00.81.10.4
Bone: stiffness0.71.12.31.21.3-0.91.50.61.30.90.9-0.51.10.51.41.20.70.9
Tibialis anterior weight0.41.35.10.10.60.40.2-0.91.30.5-0.90.71.41.81.01.92.30.8
Time to tail flick, vehicle, before self-admin0.20.20.40.50.6-0.20.50.60.20.10.5-0.4-0.1-0.4-0.0-0.6-0.50.0
Time to tail flick, vehicle, after self-admin0.91.23.70.81.2-1.01.91.01.11.31.1-1.21.3-0.71.20.20.31.1
Time to tail flick, test, before self-admin0.20.20.50.0-0.00.6-0.1-0.3-0.2-0.5-0.70.7-0.40.60.1-0.00.1-0.4
Time to tail flick, test, after self-admin0.40.41.41.21.0-0.61.10.90.70.40.2-0.10.3-0.10.00.0-0.3-0.6
Delta time to tail flick, vehicle, before/after SA2.52.44.91.21.4-1.72.21.11.81.91.3-1.32.1-0.41.91.50.91.3
Delta time to tail flick, test, before/after SA0.10.10.40.60.5-0.30.70.60.30.20.2-0.20.0-0.2-0.4-0.2-0.3-0.4
Tibia length0.30.93.31.40.9-0.41.11.2-0.2-0.60.9-0.2-1.1-0.3-0.0-1.0-1.8-0.9
Ambulatory time before self-admin0.50.82.21.31.2-0.91.21.50.20.50.8-0.90.1-0.70.5-0.9-0.8-0.7
Ambulatory time after self-admin0.10.10.5-0.10.10.40.7-0.4-0.1-0.3-0.40.3-0.10.60.40.10.40.2
Bone: tissue strength0.30.30.90.60.4-0.70.40.80.20.40.9-0.8-0.0-0.80.2-0.3-0.70.1
Total heroin consumption0.50.62.3-0.5-0.5-0.1-1.20.4-1.2-0.20.1-0.6-0.8-1.20.0-1.5-1.0-0.6
Bone: trabecular number1.72.84.71.51.7-1.91.91.32.02.21.5-1.72.1-0.32.11.61.21.5
Bone: trabecular spacing2.22.96.3-0.6-1.02.0-1.0-0.9-1.6-2.2-2.02.3-1.91.1-2.3-1.4-0.9-2.5
Bone: trabecular thickness0.40.51.9-0.7-0.30.0-0.1-0.70.40.5-0.0-0.20.80.20.90.91.21.4
Bone: trabecular tissue density0.91.45.3-2.1-1.7-0.2-1.4-1.0-1.00.21.0-1.10.1-1.30.60.20.12.3
Water consumed over 24 hours0.40.61.8-0.7-0.50.80.2-1.0-0.3-0.4-1.31.0-0.11.2-0.10.61.1-0.0
Number of responses in last shaping day1.11.22.5-0.7-1.01.0-1.0-0.5-1.3-1.4-1.11.2-1.60.3-1.3-1.2-0.9-1.6