Hub : Genes

Ehd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Ehd4 0.04 0.02 7.0e-06 0.04 0.04 0.04 0.04 6.6e-07 1.4e-06 2.2e-06 6.9e-07
2 BLA gene expression Ehd4 0.35 0.11 0.0e+00 0.26 0.27 0.27 0.28 3.3e-14 1.3e-14 2.0e-14 6.0e-15
3 PL gene expression Ehd4 0.33 0.1 0.0e+00 0.3 0.28 0.3 0.3 2.5e-33 7.7e-31 5.4e-33 1.2e-33
4 Brain gene expression Ehd4 0.29 0.11 0.0e+00 0.26 0.25 0.26 0.26 1.2e-24 2.5e-23 2.6e-24 1.6e-24
5 Liver gene expression Ehd4 0.38 0.11 0.0e+00 0.26 0.25 0.26 0.26 7.0e-29 7.0e-28 1.7e-28 5.8e-29
6 Brain mRNA stability Ehd4 0.11 0.05 2.5e-11 0.08 0.1 0.1 0.1 1.0e-07 6.9e-10 2.0e-09 4.9e-10
7 IL gene expression Ehd4 0.46 0.18 9.0e-05 0.11 0.11 0.13 0.14 1.6e-03 1.1e-03 5.1e-04 2.7e-04
8 BLA mRNA stability Ehd4 0.09 0.05 9.2e-04 0.05 0.03 0.03 0.04 1.2e-03 1.4e-02 7.4e-03 3.6e-03
9 IC gene expression Ehd4 0.39 0.14 7.6e-10 0.23 0.21 0.21 0.23 6.5e-10 3.6e-09 2.6e-09 6.7e-10
10 Adipose gene expression Ehd4 0.07 0.04 1.3e-06 0.03 0.04 0.03 0.04 2.6e-04 3.7e-05 2.7e-04 8.4e-05
11 OFC gene expression Ehd4 0.32 0.13 5.3e-05 0.14 0.16 0.14 0.15 3.2e-04 1.2e-04 2.9e-04 2.5e-04
12 pVTA gene expression Ehd4 0.13 0.06 1.1e-09 0.1 0.11 0.11 0.1 1.2e-08 4.4e-09 7.0e-09 1.5e-08
13 NAcc gene expression Ehd4 0.07 0.04 5.5e-12 0.06 0.07 0.06 0.07 7.1e-10 5.2e-11 3.6e-10 2.4e-10
14 PL mRNA stability Ehd4 0.03 0.02 1.3e-04 0.04 0.03 0.03 0.03 7.8e-05 2.1e-04 3.1e-04 6.8e-04
15 IC intron excision ratio chr3_127526411_127549688 0.12 0.07 2.3e-03 0.08 0.06 0.06 0.07 4.0e-04 2.2e-03 2.0e-03 9.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.91.62.21.21.31.21.2-1.21.31.31.21.2-1.31.20.9-1.41.5-1.4
Area under the delay curve1.01.17.30.60.70.50.6-0.61.00.70.60.6-1.3-0.1-0.9-2.71.8-0.2
BMI with tail4.716.320.34.24.34.14.2-4.24.54.34.14.1-4.43.93.0-3.54.1-3.3
BMI without tail7.021.425.94.85.14.84.8-4.84.95.04.74.7-4.84.53.6-3.84.4-4.5
Body weight6.026.431.45.55.55.35.3-5.35.65.45.35.3-5.55.04.2-4.05.2-4.2
Weight adjusted by age1.01.52.31.21.31.41.4-1.41.31.41.51.5-1.51.00.8-0.60.9-0.3
Bone surface1.22.23.31.71.61.51.5-1.51.61.51.41.4-1.11.71.7-0.71.1-1.8
Bone volume1.22.23.01.51.61.61.5-1.51.61.61.51.5-1.21.71.5-0.81.1-1.5
Breakpoint value in progressive ratio session0.20.30.8-0.7-0.4-0.5-0.50.5-0.5-0.4-0.6-0.60.9-0.1-0.00.1-0.5-0.4
Number of licking bursts0.20.30.7-0.8-0.5-0.7-0.70.7-0.6-0.5-0.6-0.60.9-0.2-0.2-0.1-0.5-0.6
Context. condit. distance diff. score2.73.34.52.02.12.02.0-2.01.82.12.02.0-1.52.01.9-0.40.7-1.9
Locomotion velocity, session 14.54.97.1-2.3-2.4-2.4-2.32.3-2.2-2.3-2.3-2.31.8-2.7-2.60.5-1.32.4
Locomotion distance, session 11.82.33.8-1.5-1.6-1.6-1.61.6-1.6-1.5-1.6-1.61.1-1.9-1.90.3-1.01.5
Locomotion velocity, session 20.50.54.5-0.00.30.10.1-0.10.40.40.10.1-0.9-0.4-1.0-2.11.1-0.0
Locomotion distance, session 20.50.71.1-0.9-0.8-0.9-0.90.9-0.9-0.8-1.0-1.00.7-1.0-1.1-0.1-0.70.2
Locomotion velocity, session 30.30.41.4-0.5-0.5-0.6-0.50.5-0.2-0.4-0.5-0.50.1-0.7-1.2-1.0-0.00.9
Locomotion distance, session 30.10.21.5-0.3-0.1-0.2-0.20.2-0.10.0-0.2-0.20.6-0.1-0.40.2-1.20.2
Stereotopy head waving bouts, day 32.63.05.11.91.81.81.8-1.82.11.81.81.8-2.31.20.7-1.62.0-0.1
Stereotopy head waving duration, day 32.42.97.51.71.51.51.5-1.51.91.61.51.5-2.30.90.2-2.62.7-0.2
Locomotion velocity, session 70.30.30.50.70.60.60.6-0.60.60.70.60.6-0.40.2-0.2-0.0-0.60.4
Locomotion distance, session 70.20.20.90.30.40.30.3-0.30.00.40.30.30.20.30.40.8-0.9-0.5
Stereotopy head waving bouts, day 70.10.10.6-0.3-0.4-0.3-0.30.3-0.2-0.4-0.3-0.30.2-0.3-0.30.1-0.10.8
Stereotopy head waving duration, day 70.00.00.6-0.1-0.2-0.0-0.00.00.2-0.20.00.00.0-0.00.10.30.10.8
Locomotion velocity, session 81.61.94.21.21.51.31.3-1.31.51.61.41.4-1.90.80.1-2.01.5-0.6
Locomotion distance, session 80.71.11.71.31.31.11.1-1.10.91.31.11.1-0.91.00.8-0.40.2-1.3
Degree of sensitization distance0.20.21.50.20.00.20.2-0.2-0.2-0.00.20.20.20.30.91.2-0.1-0.3
Degree of sensitization stereotypy0.20.31.6-0.3-0.4-0.2-0.20.2-0.3-0.4-0.2-0.20.6-0.10.21.2-0.90.6
Conditioned locomotion1.92.22.91.31.61.51.5-1.51.51.61.51.5-1.51.51.2-1.31.5-1.7
Cocaine response after cond. corrected1.92.33.4-1.7-1.6-1.9-1.81.8-1.5-1.6-1.8-1.81.7-1.3-1.5-0.4-0.90.1
Cocaine response after cond. not corrected2.83.34.9-2.0-1.9-2.2-2.22.2-1.8-2.0-2.1-2.11.8-1.8-1.9-0.6-0.90.4
Cocaine response before conditioning0.20.21.1-0.2-0.4-0.4-0.40.4-0.3-0.4-0.4-0.4-0.1-0.8-0.8-0.0-0.01.0
Saline control response2.93.95.42.22.12.32.3-2.32.22.12.22.2-2.21.81.7-0.31.6-0.4
Bone: connectivity density0.60.91.51.20.91.00.9-0.90.90.80.90.9-1.00.90.9-0.61.2-0.8
Bone: cortical apparent density0.81.04.1-0.9-0.8-0.7-0.80.8-1.0-0.9-0.8-0.81.6-0.10.52.0-1.6-0.1
Bone: cortical area2.03.04.22.11.81.81.8-1.82.01.91.81.8-1.81.71.3-1.41.7-1.1
Bone: cortical porosity1.51.64.1-1.5-1.0-1.4-1.31.3-1.2-1.0-1.3-1.30.5-1.6-2.0-1.40.10.6
Bone: cortical porosity0.40.52.2-0.6-0.3-0.5-0.40.4-0.3-0.2-0.5-0.5-0.3-0.9-1.4-1.50.50.5
Bone: cortical thickness1.21.92.71.61.41.41.4-1.41.61.51.41.4-1.61.10.6-1.61.6-0.7
Bone: cortical thickness0.10.21.0-0.4-0.1-0.3-0.30.3-0.2-0.2-0.3-0.30.50.20.2-0.70.3-1.0
Bone: cortical tissue density0.81.03.7-0.9-0.9-0.8-0.80.8-1.0-0.9-0.8-0.81.6-0.10.41.9-1.6-0.0
Condit. Reinf. active minus inactive responses0.50.65.30.2-0.30.20.1-0.1-0.2-0.20.20.20.60.10.82.3-1.30.8
Condit. Reinf. active-inactive response ratio0.60.71.00.90.71.01.0-1.00.90.81.01.0-0.50.91.00.8-0.10.1
Condit. Reinf. active responses1.11.411.2-0.2-0.8-0.2-0.30.3-0.8-0.8-0.3-0.31.2-0.20.73.3-2.11.2
Condit. Reinf. inactive responses1.31.67.9-0.9-1.1-0.8-0.80.8-1.3-1.1-0.8-0.81.6-0.70.12.8-2.10.9
Incentive salience index mean1.01.37.6-0.4-1.0-0.5-0.60.6-0.9-1.0-0.6-0.61.2-0.60.22.8-1.71.3
Condit. Reinf. lever presses0.71.05.1-0.4-1.1-0.6-0.70.7-1.0-1.1-0.7-0.71.0-0.8-0.02.3-1.31.2
Condit. Reinf. active minus inactive responses1.62.04.71.31.41.61.6-1.61.11.41.51.5-0.91.72.20.80.6-1.4
Condit. Reinf. active-inactive response ratio1.21.43.40.91.21.31.3-1.30.91.11.21.2-0.61.51.80.70.4-1.3
Condit. Reinf. active responses2.23.16.41.91.72.02.0-2.01.51.71.91.9-1.22.12.50.90.8-1.4
Condit. Reinf. inactive responses1.11.42.61.61.11.41.3-1.31.21.11.31.3-1.01.31.50.50.7-0.3
Condit. Reinf. lever presses1.31.82.81.51.21.61.6-1.61.41.31.51.5-1.31.41.70.41.1-0.2
Condit. Reinf. lever reinforcers received1.92.65.71.71.51.91.9-1.91.31.51.71.7-1.11.92.41.10.7-1.1
Conditioned reinforcement - actives0.30.51.1-1.0-0.7-0.7-0.60.6-0.9-0.6-0.7-0.70.7-0.8-0.8-0.1-0.30.5
Conditioned reinforcement - inactives0.00.10.3-0.20.30.10.2-0.2-0.10.30.30.30.10.20.1-0.1-0.3-0.5
Conditioned locomotion0.40.52.5-0.5-0.6-0.4-0.40.4-0.4-0.5-0.3-0.3-0.2-1.1-1.2-0.30.21.6
Patch foraging indifference point 0 sec1.52.75.41.81.51.81.8-1.82.01.61.71.7-2.31.10.7-1.01.91.1
Patch foraging indifference point AUC1.92.73.5-1.8-1.7-1.5-1.51.5-1.7-1.5-1.8-1.81.9-1.6-1.31.7-1.91.7
Delay disc. indifference point, 0s delay0.20.21.4-0.0-0.3-0.2-0.10.10.1-0.2-0.1-0.1-0.3-0.7-0.8-0.60.61.2
Delay disc. indifference point, 16s delay0.50.63.0-0.3-0.4-0.5-0.40.4-0.0-0.3-0.5-0.4-0.1-0.9-1.5-1.70.60.6
Delay disc. indifference point, 2s delay0.91.01.31.11.11.11.1-1.11.01.11.21.1-1.01.11.0-0.20.4-0.8
Delay disc. indifference point, 24s delay1.51.72.9-1.3-1.4-1.3-1.31.3-1.2-1.4-1.5-1.41.0-1.7-1.7-0.0-0.71.3
Delay disc. indifference point, 4s delay0.60.63.60.40.50.40.4-0.40.60.50.40.4-1.0-0.2-0.7-1.91.3-0.2
Delay disc. indifference point, 8s delay2.12.510.71.31.31.21.2-1.21.71.41.21.3-2.00.5-0.4-3.32.6-0.4
Indifference point function ln k2.74.85.62.22.42.12.1-2.12.22.32.32.3-2.32.11.5-2.32.2-2.3
Indifference point function log k2.74.85.62.22.42.12.1-2.12.22.32.32.3-2.32.11.5-2.32.2-2.3
Patch foraging total patch changes 0 sec1.32.44.41.71.41.71.7-1.71.91.51.61.6-2.11.10.8-0.81.71.0
Patch foraging total patch changes 12 sec0.30.42.10.20.30.70.7-0.70.20.50.20.2-0.20.00.21.3-0.41.4
Patch foraging total patch changes 18 sec0.30.52.0-0.6-0.6-0.3-0.30.3-0.5-0.4-0.5-0.60.6-0.6-0.31.4-1.11.3
Patch foraging total patch changes 24 sec0.81.33.31.21.21.31.3-1.31.21.20.80.8-1.50.70.6-1.21.8-0.3
Patch foraging total patch changes 6 sec0.20.32.3-0.1-0.20.10.2-0.2-0.0-0.0-0.1-0.10.0-0.2-0.11.0-0.61.5
Patch foraging time to switch 0 sec0.20.31.8-0.5-0.6-0.3-0.30.3-0.6-0.6-0.3-0.30.4-0.40.11.4-0.60.8
Patch foraging water rate 0 sec0.71.52.41.41.41.31.3-1.31.41.41.21.2-0.81.51.4-0.30.5-1.3
Patch foraging water rate 12 sec0.20.43.50.00.40.10.0-0.00.10.30.10.10.40.80.7-0.5-0.2-1.9
Patch foraging water rate 18 sec0.30.52.80.30.60.20.2-0.20.60.50.40.4-0.40.60.1-1.70.8-1.3
Patch foraging water rate 24 sec0.60.92.40.80.90.80.8-0.80.90.90.90.8-0.11.51.50.3-0.4-1.5
Patch foraging water rate 6 sec0.50.72.2-0.7-0.6-0.7-0.80.8-0.8-0.7-0.6-0.61.40.20.41.0-1.5-0.9
Seeking ratio, delayed vs. immediate footshock0.91.12.60.61.21.11.1-1.10.51.11.11.1-0.41.41.60.6-0.0-1.5
Distance traveled before self-admin0.60.81.40.71.00.90.9-0.90.81.00.80.8-0.80.80.6-1.11.2-1.1
Distance traveled after self-admin0.20.20.80.30.40.40.4-0.40.30.30.30.30.00.70.90.10.3-0.9
Extensor digitorum longus weight0.20.81.60.91.00.90.9-0.91.21.10.80.8-1.00.80.3-1.30.9-0.4
Bone: elastic displacement0.10.11.1-0.5-0.3-0.2-0.10.1-0.1-0.2-0.1-0.1-0.0-0.4-0.60.0-0.11.0
Bone: elastic work0.60.71.30.80.81.01.0-1.01.20.91.01.0-1.00.80.6-0.20.60.4
Bone: endosteal estimation0.10.31.30.40.50.40.4-0.40.40.50.40.4-0.00.70.7-0.10.1-1.1
Bone: endosteal perimeter0.10.10.30.50.30.30.3-0.30.30.30.30.3-0.00.40.50.10.0-0.5
Epididymis fat weight0.30.93.30.70.90.70.8-0.81.01.00.80.8-1.30.4-0.1-1.81.3-0.5
Delta time in closed arm before/after self-admin0.20.20.50.30.40.40.4-0.40.10.40.40.40.10.40.40.7-0.7-0.4
Delta time in open arm before/after self-admin1.81.75.11.31.41.21.2-1.21.11.41.31.3-0.71.71.6-0.40.5-2.3
Diff in mean of infusions in LGA sessions0.10.21.3-0.0-0.20.10.1-0.1-0.2-0.1-0.0-0.00.20.00.41.2-0.60.5
Delay discount exponential model param0.80.96.2-0.5-0.6-0.4-0.50.5-0.8-0.6-0.5-0.51.10.20.92.5-1.60.2
Extinction: sum of active levers before priming1.31.42.0-1.4-1.3-1.3-1.31.3-1.3-1.2-1.2-1.21.0-1.3-1.30.2-0.81.1
Active lever presses in extinction session 60.60.61.5-0.8-0.6-0.7-0.60.6-0.8-0.6-0.8-0.80.5-1.1-1.2-0.4-0.30.8
Bone: final force1.42.23.71.91.61.71.7-1.71.61.71.71.7-1.11.71.60.30.3-0.9
Bone: final moment1.11.83.21.81.51.61.5-1.51.51.51.51.5-1.01.51.50.30.2-0.7
Food consumed during 24 hour testing period0.10.10.6-0.4-0.2-0.4-0.40.4-0.4-0.3-0.4-0.40.4-0.1-0.1-0.3-0.1-0.8
Glucose1.42.13.41.41.81.61.7-1.71.61.81.61.6-1.21.61.1-0.70.2-1.4
Heart weight5.17.910.03.23.13.03.0-3.02.93.12.92.8-2.92.62.2-2.12.6-2.5
Delay discount hyperbolic model param0.80.95.2-0.6-0.7-0.6-0.70.7-0.9-0.8-0.6-0.71.2-0.10.62.3-1.60.4
Intermittent access intake day 1-15 change0.20.53.50.40.70.30.3-0.30.50.60.50.5-0.11.00.8-0.70.3-1.9
Intermittent access intake escalation0.40.84.00.60.90.50.5-0.50.70.80.70.7-0.31.21.0-0.90.6-2.0
Intermittent access intake escalation 20.40.52.9-0.6-0.1-0.6-0.60.6-0.4-0.2-0.5-0.50.70.0-0.3-1.1-0.2-1.7
Intermitt. access day 1 inactive lever presses0.62.33.91.71.51.61.5-1.51.61.41.71.7-2.01.31.2-0.91.7-0.8
Intermitt. access day 15 inactive lever presses0.61.21.61.11.31.21.2-1.21.11.31.31.3-1.01.21.1-0.10.4-0.9
Intermitt. access escalation Index0.71.02.81.20.81.01.0-1.01.00.81.01.0-0.61.41.71.00.1-0.4
Intermittent access day 1 total infusions0.30.42.2-0.7-0.5-0.4-0.30.3-0.5-0.4-0.4-0.40.3-0.8-0.90.3-0.51.5
Intermittent access day 15 total infusions0.20.30.50.40.70.60.7-0.70.60.70.60.6-0.40.70.6-0.20.2-0.6
Intermittent access terminal intake (last 3 days)0.10.20.90.00.50.30.3-0.30.20.50.30.30.00.50.3-0.60.0-1.0
Intermittent access total infusions0.10.10.2-0.10.30.30.4-0.40.20.40.20.2-0.20.10.0-0.20.1-0.0
Intermittent access day 1 locomotion0.40.51.20.30.40.50.6-0.60.60.50.60.6-1.1-0.2-0.6-1.00.91.1
Intermittent access day 15 total locomotion0.40.71.80.51.00.70.8-0.80.60.90.80.8-0.70.80.5-0.90.6-1.4
Intermittent access total locomotion0.10.10.7-0.10.20.20.2-0.20.10.30.20.2-0.4-0.2-0.4-0.80.5-0.0
Intermittent access standard deviation0.10.20.90.30.50.20.2-0.20.40.40.40.4-0.10.60.3-0.4-0.2-1.0
Left kidney weight2.913.519.73.84.13.83.9-3.94.04.13.93.9-4.43.01.9-3.53.5-2.5
Right kidney weight4.118.828.44.54.74.44.5-4.54.74.74.54.5-5.33.42.2-4.44.7-2.8
Cocaine induced anxiety0.81.22.91.21.11.21.2-1.21.11.21.21.2-1.70.30.1-0.81.10.3
Post-drug Anxiety2.02.13.61.71.71.71.7-1.71.41.71.71.7-1.91.00.8-0.61.1-0.7
Baseline Anxiety0.20.20.60.40.40.40.4-0.40.20.40.40.40.00.60.80.4-0.3-0.8
Tail length2.710.413.33.33.63.43.4-3.43.13.53.43.4-3.13.32.9-2.12.8-3.5
Length with tail1.88.09.83.13.13.03.0-3.02.93.03.13.1-2.92.92.6-1.62.5-2.3
Length without tail0.72.12.91.71.51.41.4-1.41.61.51.51.5-1.61.51.2-1.21.5-1.0
Times rat made contact with spout0.30.30.60.50.50.60.6-0.60.70.60.60.6-0.80.30.1-0.50.60.4
Lifetime Intake0.10.10.2-0.4-0.1-0.1-0.00.0-0.1-0.0-0.2-0.20.1-0.3-0.4-0.40.10.4
Liver weight, left5.18.410.03.12.92.92.8-2.83.02.82.92.9-2.93.23.0-1.93.1-3.2
Liver weight, right2.34.05.52.12.12.02.0-2.02.32.12.22.2-2.31.91.4-1.82.2-1.0
Locomotor activity0.30.40.7-0.7-0.7-0.7-0.70.7-0.8-0.7-0.7-0.70.4-0.8-0.80.0-0.10.8
Locomotor testing distance0.50.92.2-1.0-1.0-0.9-0.90.9-1.1-0.9-0.9-0.90.7-1.2-1.10.5-0.71.5
Locomotor testing rearing0.81.72.7-1.2-1.3-1.2-1.21.2-1.6-1.3-1.2-1.21.4-1.2-0.81.6-1.71.2
Locomotion in novel chamber0.30.30.50.50.60.70.7-0.70.70.70.70.7-0.70.50.3-0.10.40.4
Locomotion in novel chamber post-restriction1.72.88.31.61.61.41.4-1.41.51.51.41.4-1.21.91.9-1.41.9-2.9
Fecal boli incidents, locomotor time 11.11.62.6-1.4-1.4-1.4-1.41.4-1.1-1.4-1.3-1.31.1-1.5-1.6-0.1-0.71.2
Change in fecal boli incidents, locomotor task3.13.04.01.82.01.91.9-1.91.72.01.91.9-1.71.81.6-0.81.0-1.6
Time >=10cm from walls, locomotor time 10.10.10.3-0.3-0.1-0.2-0.20.2-0.2-0.1-0.2-0.20.40.30.40.4-0.6-0.5
Bouts of movement, locomotor time 14.65.36.7-2.6-2.5-2.5-2.52.5-2.4-2.5-2.4-2.52.4-2.4-2.20.8-1.61.8
Total resting periods, locomotor time 14.34.85.9-2.4-2.4-2.4-2.42.4-2.3-2.4-2.3-2.42.3-2.2-1.91.2-1.81.8
Rest time, locomotor task time 10.00.00.30.0-0.10.10.1-0.10.0-0.0-0.1-0.10.10.10.30.6-0.50.0
Distance moved, locomotor task time 10.10.21.0-0.4-0.3-0.2-0.20.2-0.3-0.2-0.3-0.20.4-0.3-0.20.7-0.41.0
Vertical activity count, locomotor time 10.10.20.80.20.50.40.4-0.40.20.40.40.4-0.20.70.90.10.5-0.7
Time >=10cm from walls, locomotor time 28.212.114.73.73.63.63.6-3.63.73.63.83.7-3.83.53.3-2.03.5-2.6
Bouts of movement, locomotor time 20.20.31.30.50.20.30.2-0.20.50.10.40.3-0.20.91.10.00.8-0.7
Total resting periods, locomotor time 20.10.21.20.30.10.20.1-0.10.40.00.20.2-0.00.91.10.10.6-0.7
Rest time, locomotor task time 24.45.57.9-2.5-2.5-2.3-2.32.3-2.5-2.3-2.6-2.52.6-2.3-2.01.8-2.81.7
Distance moved, locomotor task time 22.02.43.21.71.71.71.7-1.71.61.61.81.8-1.81.41.2-0.61.6-0.3
Vertical activity count, locomotor time 24.05.67.72.52.42.42.4-2.42.42.32.62.6-2.32.82.8-0.72.2-1.9
Light reinforcement 11.22.84.21.61.42.02.1-2.11.81.52.02.0-1.81.41.71.20.71.2
Light reinforcement 20.50.72.4-1.0-0.8-0.6-0.50.5-0.9-0.7-0.7-0.70.9-0.7-0.31.6-1.11.0
Bone: marrow area0.10.31.30.50.60.50.5-0.50.50.60.40.4-0.10.80.7-0.20.2-1.1
Bone: maximum diameter1.22.33.31.81.61.61.6-1.61.61.61.61.6-1.31.71.6-0.61.2-1.2
Bone: maximum force2.34.16.42.52.22.32.3-2.32.32.32.32.3-2.02.01.7-0.71.4-1.1
Bone: maximum moment1.93.35.32.32.02.12.0-2.02.12.02.02.0-1.81.71.5-0.61.2-0.9
Mean time between licks in bursts0.71.62.6-1.4-1.3-1.5-1.51.5-1.3-1.4-1.4-1.41.0-1.5-1.6-0.3-0.60.8
Mean num. licks in bursts0.60.91.61.20.91.11.1-1.11.11.01.11.1-1.30.60.5-0.00.80.6
Cd content in liver0.30.40.60.70.60.60.5-0.50.80.50.60.6-0.50.70.7-0.30.6-0.5
Co content in liver0.30.31.9-0.3-0.3-0.5-0.40.4-0.0-0.2-0.5-0.5-0.1-0.4-0.9-1.40.50.3
Cu content in liver0.40.40.9-0.5-0.6-0.7-0.70.7-0.7-0.6-0.7-0.71.0-0.4-0.30.5-0.9-0.3
Fe content in liver1.31.68.3-0.3-1.1-0.7-0.90.9-1.0-1.2-0.9-0.91.8-0.30.62.9-2.00.3
K content in liver0.40.42.10.30.50.30.3-0.30.30.40.30.3-0.30.50.3-1.20.8-1.5
Mg content in liver0.90.94.00.71.00.70.7-0.70.70.90.70.7-0.41.10.8-1.30.7-2.0
Mn content in liver1.92.12.71.61.61.61.6-1.61.51.71.61.6-1.61.20.9-0.91.3-0.6
Na content in liver0.50.50.9-0.6-0.7-0.7-0.80.8-1.0-0.8-0.8-0.80.9-0.5-0.20.3-0.3-0.6
Rb content in liver3.13.65.42.02.11.91.9-1.92.22.11.91.9-2.11.71.0-2.31.9-1.5
Se content in liver0.10.10.10.00.30.20.3-0.30.30.30.30.3-0.10.30.20.3-0.30.0
Sr content in liver0.30.30.4-0.5-0.5-0.6-0.60.6-0.4-0.6-0.6-0.60.1-0.6-0.7-0.40.20.4
Zn content in liver0.50.61.8-0.6-0.5-0.6-0.60.6-0.8-0.6-0.6-0.61.30.10.50.8-0.8-1.3
Bone: minimum diameter1.11.94.91.51.31.21.2-1.21.61.31.21.2-1.80.80.2-2.22.1-0.4
Time in familiar zone, hab. session 11.71.62.3-1.5-1.4-1.5-1.51.5-1.4-1.5-1.5-1.51.5-1.1-0.90.1-0.6-0.0
Time in novel zone, hab. session 12.52.53.71.71.71.91.9-1.91.71.81.91.9-1.71.51.30.00.6-0.1
Total zone transitions, hab. session 10.60.81.1-1.0-1.0-1.0-1.01.0-1.1-1.0-1.1-1.10.7-1.0-0.9-0.40.20.1
Total locomotion distance, hab. session 10.50.71.2-1.0-0.9-0.9-0.90.9-1.0-0.9-0.9-0.90.4-1.1-1.0-0.50.20.3
Locomotion velocity, hab. session 10.81.11.9-1.2-1.2-1.1-1.11.1-1.3-1.2-1.2-1.20.6-1.4-1.2-0.30.10.6
Time in familiar zone, hab. session 20.00.00.20.0-0.00.0-0.00.00.1-0.0-0.0-0.00.20.30.4-0.00.3-0.4
Time in novel zone, hab. session 20.40.40.80.60.70.70.8-0.80.60.80.80.8-0.90.3-0.0-0.30.20.2
Total zone transitions, hab. session 20.40.50.9-0.6-0.6-0.8-0.80.8-0.7-0.7-0.8-0.80.4-0.8-0.9-1.00.3-0.3
Total locomotion distance, hab. session 20.00.00.20.1-0.0-0.0-0.10.1-0.1-0.1-0.0-0.0-0.2-0.2-0.2-0.50.3-0.3
Locomotion velocity, hab. session 20.10.10.2-0.1-0.3-0.2-0.30.3-0.3-0.3-0.3-0.3-0.0-0.4-0.3-0.40.3-0.2
Novel to familiar place preference ratio1.92.12.91.71.51.61.7-1.71.61.51.61.6-1.61.31.3-0.21.2-0.4
Novelty place preference1.81.92.61.61.41.61.6-1.61.61.51.61.6-1.51.21.2-0.31.1-0.3
Time in novel zone, NPP test1.71.92.51.61.41.61.6-1.61.51.51.61.6-1.51.21.2-0.21.0-0.3
Total zone transitions, NPP test1.42.03.2-1.5-1.4-1.6-1.61.6-1.5-1.4-1.6-1.61.2-1.6-1.8-0.9-0.50.0
Total locomotion distance, NPP test0.50.72.4-0.7-0.6-0.8-0.80.8-0.7-0.6-0.8-0.80.2-1.2-1.6-1.30.10.1
Locomotion velocity, NPP test0.70.93.1-0.8-0.7-1.0-1.01.0-0.8-0.7-0.9-0.90.2-1.4-1.8-1.40.10.3
Intraocular pressure1.62.35.2-1.6-1.7-1.5-1.51.5-1.3-1.6-1.5-1.51.3-1.5-1.41.0-1.22.3
Delta distance traveled before/after self-admin0.20.20.6-0.2-0.5-0.4-0.50.5-0.3-0.6-0.4-0.40.4-0.10.10.8-0.50.4
Delta ambulatory time before/after self-admin0.30.41.8-0.4-0.7-0.5-0.50.5-0.5-0.7-0.5-0.50.6-0.4-0.01.3-0.70.9
Parametrial fat weight0.10.20.50.70.30.50.5-0.50.40.30.50.5-0.7-0.00.00.10.30.6
Pavlov. Cond. lever latency0.20.30.60.50.60.50.5-0.50.70.60.50.5-0.10.80.6-0.10.0-0.6
Pavlov. Cond. magazine entry latency0.60.81.70.90.71.11.1-1.10.70.71.11.1-0.90.61.01.3-0.00.5
Pavlov. Cond. change in total contacts0.20.20.50.40.50.50.5-0.50.10.40.50.5-0.20.30.50.7-0.4-0.5
Pavlov. Cond. index score0.10.10.7-0.2-0.4-0.1-0.10.1-0.3-0.3-0.1-0.10.0-0.4-0.10.8-0.30.7
Pavlov. Cond. latency score0.10.10.5-0.1-0.3-0.0-0.00.0-0.2-0.3-0.1-0.1-0.2-0.4-0.10.50.10.7
Pavlov. Cond. lever contacts0.20.20.5-0.5-0.6-0.4-0.40.4-0.7-0.6-0.4-0.40.2-0.7-0.50.5-0.20.6
Pavlov. Cond. magazine entry number0.60.81.2-0.9-0.8-1.1-1.11.1-0.8-0.8-1.1-1.10.9-0.6-0.9-0.9-0.1-0.4
Pavlov. Cond. intertrial magazine entries0.30.31.2-0.1-0.3-0.4-0.40.4-0.4-0.4-0.4-0.41.10.30.50.7-0.8-0.7
Pavlov. Cond. lever-magazine prob. diff.0.20.20.7-0.4-0.5-0.3-0.30.3-0.5-0.5-0.3-0.30.2-0.6-0.30.8-0.50.8
Pavlov. Cond. response bias0.20.22.0-0.0-0.10.20.2-0.2-0.3-0.00.10.10.1-0.10.31.4-0.80.5
Pavlov. Cond. lever latency3.64.97.0-2.5-2.3-2.6-2.62.6-2.4-2.3-2.5-2.52.1-2.3-2.3-0.2-1.40.6
Pavlov. Cond. magazine entry latency2.02.44.41.81.41.81.8-1.81.51.41.81.8-1.01.72.11.6-0.0-0.2
Pavlov. Cond. change in total contacts1.72.75.41.81.62.01.9-1.91.51.61.81.8-1.01.82.31.50.2-0.8
Pavlov. Cond. index score3.24.37.42.42.02.52.4-2.42.12.12.32.3-1.52.32.71.50.4-0.7
Pavlov. Cond. latency score2.63.56.02.11.82.22.2-2.21.81.92.12.1-1.32.12.41.40.3-0.7
Pavlov. Cond. lever contacts4.05.57.72.62.42.82.8-2.82.52.42.62.6-2.22.42.60.31.5-0.7
Pavlov. Cond. magazine entry number2.42.95.4-2.0-1.6-2.0-1.91.9-1.6-1.6-1.9-1.91.1-1.9-2.3-1.5-0.00.7
Pavlov. Cond. intertrial magazine entries0.30.43.6-0.3-0.1-0.4-0.30.3-0.0-0.1-0.3-0.3-0.4-0.5-1.1-1.90.90.1
Pavlov. Cond. lever-magazine prob. diff.3.04.06.82.32.02.42.3-2.32.02.02.32.3-1.42.22.61.40.4-0.6
Pavlov. Cond. response bias4.96.79.92.92.63.13.0-3.02.72.62.92.9-2.22.83.20.91.2-0.9
Time in closed arm before self-admin2.22.84.2-1.6-2.0-1.8-1.91.9-1.7-2.1-1.8-1.81.8-1.4-0.91.5-1.31.5
Time in closed arm after self-admin1.01.13.6-0.7-1.1-0.9-1.01.0-1.0-1.1-0.9-0.91.3-0.50.01.9-1.60.7
Time in open arm before self-admin0.40.40.80.60.70.70.8-0.80.90.80.50.5-0.90.40.0-0.80.70.3
Time in open arm after self-admin2.22.43.81.41.81.61.6-1.61.51.91.61.6-1.31.71.2-1.41.0-2.0
Bone: periosteal estimation0.81.62.31.51.41.31.3-1.31.51.41.31.3-1.21.31.1-0.91.1-1.1
Bone: periosteal perimeter0.91.52.11.41.31.31.3-1.31.51.31.31.3-1.41.00.6-1.21.3-0.5
Bone: post-yield work0.10.10.40.1-0.1-0.2-0.30.3-0.3-0.1-0.3-0.30.1-0.3-0.4-0.4-0.0-0.6
Progressive ratio test 1 active lever presses0.10.10.4-0.5-0.2-0.1-0.10.1-0.3-0.2-0.2-0.20.3-0.3-0.20.5-0.30.6
Progressive ratio test 1 breakpoint0.10.10.4-0.5-0.2-0.1-0.10.1-0.4-0.2-0.2-0.20.2-0.3-0.20.5-0.30.6
Progressive ratio test 1 inactive lever presses0.10.10.6-0.10.10.20.3-0.3-0.10.20.20.2-0.00.00.20.8-0.50.4
Progressive ratio test 2 active lever presses0.10.10.6-0.10.20.40.4-0.4-0.00.30.20.20.20.20.40.8-0.50.0
Progressive ratio test 2 breakpoint0.20.20.40.10.40.60.6-0.60.20.50.40.40.00.40.60.6-0.3-0.1
Progressive ratio test 2 inactive lever presses0.20.30.70.30.70.80.8-0.80.40.80.60.6-0.30.40.40.2-0.2-0.1
Incentive Sensitization - Responses0.00.00.1-0.10.10.20.2-0.20.00.20.00.00.20.1-0.00.1-0.2-0.1
Incentive Sensitization - Breakpoint0.00.00.1-0.00.20.30.3-0.30.10.30.10.10.10.20.10.2-0.2-0.1
Sum of active levers in priming session hrs 5-60.20.20.4-0.5-0.3-0.4-0.40.4-0.6-0.3-0.4-0.40.7-0.2-0.20.2-0.7-0.4
Progressive ratio0.10.10.3-0.0-0.2-0.3-0.30.3-0.0-0.4-0.2-0.20.20.30.50.20.3-0.5
Food seeking constrained by brief footshock0.00.10.1-0.2-0.2-0.3-0.30.3-0.3-0.3-0.3-0.30.0-0.3-0.2-0.00.10.3
Seeking ratio, punishment vs. effort0.10.10.6-0.2-0.2-0.0-0.00.0-0.3-0.0-0.1-0.10.1-0.4-0.50.3-0.50.8
Retroperitoneal fat weight3.615.319.34.34.14.34.3-4.34.34.14.44.4-4.33.83.5-1.53.4-2.0
Reaction time number correct2.34.47.02.22.32.02.0-2.02.32.22.12.1-1.92.42.0-1.51.7-2.7
Reaction time mean minus median0.51.31.70.91.31.31.3-1.31.01.31.31.3-1.21.11.0-0.81.3-0.9
Reaction time mean minus median AUC1.64.05.21.92.22.22.3-2.32.02.32.22.2-2.11.81.5-1.32.0-1.3
Reaction time num false alarms0.00.00.20.3-0.10.0-0.00.00.0-0.00.10.0-0.2-0.2-0.30.2-0.30.5
Reaction time num false alarms AUC0.00.10.40.1-0.1-0.1-0.10.1-0.2-0.2-0.1-0.10.1-0.1-0.00.7-0.50.3
Reaction time trials correct on left2.34.47.02.22.32.02.0-2.02.32.22.12.1-1.92.42.0-1.51.7-2.7
Reaction time trials on left2.44.56.92.22.32.02.0-2.02.32.22.12.1-1.92.42.1-1.51.7-2.6
Reaction time mean0.30.42.0-0.3-0.6-0.4-0.40.4-0.6-0.6-0.4-0.40.90.00.51.4-0.90.2
Reaction time mean AUC0.10.10.9-0.0-0.3-0.1-0.10.1-0.2-0.3-0.1-0.10.50.20.60.9-0.4-0.0
Median of all reaction times1.21.84.5-1.0-1.4-1.2-1.31.3-1.3-1.5-1.3-1.21.8-0.7-0.02.1-1.70.7
Reaction time omissions0.71.01.71.01.01.11.2-1.21.11.01.31.3-1.30.90.8-0.20.9-0.1
Reaction time false alarm rate0.81.12.4-0.8-1.1-0.9-0.90.9-1.1-1.1-1.0-1.00.8-1.2-0.91.2-1.11.6
Reaction time premature initiation rate0.50.84.0-0.6-0.8-0.5-0.60.6-0.9-0.9-0.7-0.70.9-0.50.32.0-1.00.8
Reaction time premature initiations0.20.41.80.50.40.60.5-0.50.30.30.40.4-0.10.81.31.2-0.2-0.6
Std. dev. reaction times0.71.21.71.01.21.31.3-1.31.11.21.31.3-1.11.21.2-0.41.1-0.5
Reaction time trials completed2.44.56.92.22.32.02.0-2.02.32.22.12.1-1.92.42.1-1.51.7-2.6
Reaction time trials AUC2.44.57.32.22.32.12.0-2.02.32.22.12.1-1.82.62.3-1.21.5-2.7
Run reversals in cocaine runway, females0.10.11.30.10.40.10.1-0.10.00.30.20.2-0.10.30.2-0.60.2-1.2
Run reversals in cocaine runway, males1.71.72.1-1.1-1.4-1.4-1.51.5-1.2-1.4-1.5-1.51.3-1.2-1.10.8-1.40.9
Latency to leave start box in cocaine runway0.10.10.50.2-0.2-0.0-0.10.10.1-0.2-0.0-0.00.20.30.60.7-0.1-0.2
Latency to leave start box in cocaine runway, F0.50.50.9-0.7-0.9-0.9-0.90.9-0.7-0.9-0.8-0.80.7-0.8-0.7-0.1-0.10.1
Latency to leave start box in cocaine runway, M2.01.85.21.51.21.41.4-1.41.21.11.41.4-0.71.82.31.40.1-0.8
Std. dev. time between licks in bursts0.91.23.11.01.11.01.0-1.01.21.11.01.0-1.50.60.1-1.81.6-0.3
Total sessions with >9 infusions0.81.02.4-1.2-1.0-1.0-0.90.9-0.8-1.0-0.9-0.90.4-1.2-1.3-0.40.21.6
Short access day 1 total inactive lever presses0.50.74.10.50.60.40.4-0.40.80.60.50.5-1.10.1-0.4-2.01.5-0.4
Short access day 10 total inactive lever presses1.12.73.61.91.91.81.8-1.81.51.91.81.8-1.61.61.6-0.30.7-1.9
Short access day 1 total infusions1.01.32.7-1.4-1.1-1.2-1.21.2-1.0-1.1-1.2-1.20.7-1.4-1.7-0.7-0.11.2
Short access day 10 total infusions0.20.30.7-0.8-0.5-0.5-0.40.4-0.6-0.5-0.5-0.50.3-0.6-0.40.10.10.7
Short access total infusions0.40.61.2-1.1-0.8-0.8-0.70.7-0.7-0.7-0.8-0.80.5-0.8-0.9-0.50.20.8
Short access day 1 locomotion1.21.53.0-1.3-1.4-1.2-1.21.2-1.2-1.3-1.2-1.20.9-1.4-1.40.4-0.81.7
Short access day 10 total locomotion0.40.76.0-0.30.2-0.10.0-0.00.20.3-0.1-0.1-0.8-0.7-1.5-2.41.20.1
Short access total locomotion0.40.41.6-0.3-0.2-0.1-0.00.00.1-0.10.0-0.0-0.7-0.8-1.1-1.31.01.2
One hour access (0.3 mA shock)0.30.42.00.10.50.30.3-0.30.10.50.30.30.50.80.90.5-0.8-1.4
Compulsive drug intake0.40.52.80.60.60.40.3-0.30.50.40.50.50.01.21.2-0.1-0.0-1.7
One hour access (shock baseline)0.10.10.7-0.10.00.20.2-0.2-0.10.10.10.10.1-0.10.10.9-0.60.5
Social response proportion1.61.86.01.11.01.31.3-1.30.60.91.21.2-0.21.62.42.4-0.9-0.9
Social responses1.01.311.8-0.1-0.30.20.2-0.2-0.3-0.20.10.11.00.51.43.4-2.00.9
Social time0.30.41.70.50.40.50.5-0.50.40.30.50.50.10.91.31.0-0.2-0.5
Soleus weight0.10.20.90.40.10.30.2-0.20.20.10.20.20.30.60.91.0-0.5-0.4
Bone: stiffness1.62.64.52.11.81.91.8-1.81.71.71.81.8-1.61.61.5-0.51.1-1.2
Tibialis anterior weight0.41.33.61.11.01.21.1-1.10.91.01.01.0-0.11.61.91.1-0.3-1.2
Time to tail flick, vehicle, before self-admin0.20.21.2-0.2-0.1-0.2-0.20.20.2-0.1-0.1-0.1-0.4-0.3-0.6-1.11.00.4
Time to tail flick, vehicle, after self-admin0.10.10.8-0.00.20.00.1-0.10.30.20.00.0-0.10.20.0-0.90.7-0.4
Time to tail flick, test, before self-admin0.00.00.20.1-0.1-0.0-0.00.00.1-0.1-0.1-0.1-0.2-0.10.00.10.50.4
Time to tail flick, test, after self-admin0.50.61.30.80.70.70.7-0.70.90.70.60.6-0.80.70.7-0.71.1-0.5
Delta time to tail flick, vehicle, before/after SA1.81.72.71.31.51.41.4-1.41.21.51.31.3-0.81.61.5-0.40.6-1.6
Delta time to tail flick, test, before/after SA0.10.10.10.20.30.30.3-0.30.20.30.30.3-0.20.20.2-0.30.2-0.1
Tibia length0.61.64.11.51.11.31.3-1.31.51.21.31.3-2.00.40.1-1.21.60.6
Ambulatory time before self-admin0.40.71.40.70.80.80.8-0.80.80.90.70.7-0.80.60.3-1.21.1-0.8
Ambulatory time after self-admin0.10.10.7-0.1-0.1-0.0-0.00.0-0.2-0.1-0.2-0.20.50.10.30.8-0.60.0
Bone: tissue strength0.20.20.50.40.50.50.5-0.50.50.60.50.5-0.70.0-0.3-0.70.40.1
Total heroin consumption0.81.02.2-1.3-0.9-1.0-1.01.0-1.0-0.8-1.1-1.10.7-1.3-1.5-0.8-0.20.4
Bone: trabecular number2.03.35.61.92.01.91.8-1.81.82.01.81.8-1.52.01.7-1.21.4-2.4
Bone: trabecular spacing1.11.46.2-1.0-1.3-1.0-1.01.0-0.8-1.2-1.0-1.00.8-1.3-1.11.1-0.82.5
Bone: trabecular thickness0.20.21.1-0.6-0.2-0.3-0.30.3-0.4-0.3-0.3-0.30.80.30.60.4-0.4-1.1
Bone: trabecular tissue density2.33.45.2-2.2-1.7-2.1-2.12.1-2.2-1.8-2.1-2.12.3-1.5-1.30.6-1.9-0.6
Water consumed over 24 hours0.10.21.3-0.1-0.3-0.2-0.20.2-0.2-0.3-0.2-0.20.60.10.31.1-0.80.3
Number of responses in last shaping day0.60.72.7-0.9-0.9-0.7-0.70.7-0.8-0.8-0.6-0.70.5-1.0-0.90.5-0.51.6