Hub : Genes

Ehd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ehd4 0.28 0.09 0.0e+00 0.3 0.28 0.29 0.3 1.2e-28 2.8e-26 1.7e-27 6.9e-28
2 BLA mRNA stability Ehd4 0.07 0.05 5.3e-03 0.03 0.01 0.01 0.01 9.3e-03 4.9e-02 9.7e-02 6.5e-02
3 PL gene expression Ehd4 0.26 0.08 0.0e+00 0.29 0.26 0.28 0.29 6.4e-32 3.2e-28 2.7e-31 5.3e-32
4 Liver gene expression Ehd4 0.38 0.11 0.0e+00 0.26 0.24 0.25 0.26 2.2e-28 6.2e-27 6.6e-28 2.5e-28
5 Brain mRNA stability Ehd4 0.12 0.05 6.6e-13 0.16 0.13 0.14 0.15 2.0e-14 2.4e-12 2.8e-13 1.4e-13
6 IL gene expression Ehd4 0.41 0.19 8.4e-04 0.07 0.08 0.05 0.09 1.0e-02 7.1e-03 2.0e-02 3.3e-03
7 Adipose gene expression Ehd4 0.08 0.05 2.3e-06 0.02 0.03 0.03 0.03 2.1e-03 2.9e-04 2.9e-04 4.7e-04
8 BLA gene expression Ehd4 0.37 0.12 0.0e+00 0.26 0.28 0.28 0.29 3.1e-14 3.7e-15 2.2e-15 1.2e-15
9 OFC gene expression Ehd4 0.3 0.13 3.3e-04 0.12 0.13 0.13 0.13 8.9e-04 5.7e-04 6.2e-04 6.8e-04
10 PL mRNA stability Ehd4 0.03 0.02 1.4e-04 0.02 0.03 0.02 0.02 1.0e-03 4.1e-04 2.2e-03 1.8e-03
11 NAcc mRNA stability Ehd4 0.04 0.02 7.8e-05 0.02 0.03 0.03 0.02 1.0e-03 2.5e-04 4.8e-04 7.7e-04
12 NAcc gene expression Ehd4 0.05 0.03 2.6e-07 0.05 0.06 0.04 0.06 7.7e-07 1.3e-07 7.6e-06 1.6e-07
13 pVTA gene expression Ehd4 0.15 0.08 4.2e-05 0.11 0.08 0.06 0.07 2.2e-05 3.5e-04 1.1e-03 7.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.42.2-1.0-1.01.01.0-1.01.3-1.01.21.01.51.3-1.5-1.1
Area under the delay curve0.91.05.9-0.5-0.50.50.5-0.50.8-1.01.0-0.21.60.2-2.4-0.3
BMI with tail5.016.319.7-4.1-4.14.04.0-3.94.1-3.94.33.94.44.2-3.5-4.2
BMI without tail5.110.613.8-3.2-3.13.23.2-3.13.7-3.13.32.93.73.3-3.3-3.0
Body weight6.025.128.1-5.1-5.15.15.1-5.05.1-5.05.34.85.25.1-3.8-5.2
Weight adjusted by age0.91.01.9-1.0-1.11.11.1-1.10.9-1.41.00.70.90.6-0.7-0.7
Bone surface1.01.72.5-1.3-1.31.31.3-1.31.4-0.91.31.51.31.6-0.9-1.4
Bone volume1.01.82.5-1.3-1.31.31.3-1.31.5-0.91.31.51.41.6-1.0-1.2
Breakpoint value in progressive ratio session0.10.10.30.1-0.00.00.1-0.10.30.40.10.40.20.5-0.1-0.3
Number of licking bursts0.30.31.20.70.7-0.7-0.70.7-0.31.1-0.7-0.2-0.2-0.1-0.10.6
Context. condit. distance diff. score2.73.24.7-2.0-2.02.02.0-2.02.2-1.51.52.11.42.1-0.7-1.3
Locomotion velocity, session 14.54.97.02.32.5-2.3-2.32.3-2.31.7-2.1-2.7-1.9-2.60.82.2
Locomotion distance, session 11.92.43.71.61.7-1.6-1.61.6-1.51.1-1.5-1.9-1.4-1.90.51.7
Locomotion velocity, session 20.50.54.2-0.1-0.10.10.1-0.10.5-0.80.5-0.41.1-0.0-2.00.1
Locomotion distance, session 20.60.81.10.91.0-1.0-1.01.0-0.70.7-0.9-1.0-0.7-0.90.01.0
Locomotion velocity, session 30.30.41.00.50.6-0.6-0.60.6-0.20.3-0.4-0.70.2-0.5-0.91.0
Locomotion distance, session 30.30.32.10.30.3-0.3-0.30.30.10.8-0.8-0.1-0.2-0.10.11.4
Stereotopy head waving bouts, day 32.73.25.1-1.8-1.81.81.8-1.81.7-2.32.01.32.01.3-1.8-1.5
Stereotopy head waving duration, day 33.23.97.4-1.7-1.81.71.7-1.71.8-2.52.31.12.61.4-2.7-1.9
Locomotion velocity, session 70.20.30.7-0.6-0.60.60.6-0.60.9-0.40.10.30.30.3-0.30.7
Locomotion distance, session 70.10.10.4-0.3-0.30.30.3-0.30.40.2-0.20.4-0.30.30.60.4
Stereotopy head waving bouts, day 70.10.10.2-0.4-0.30.30.3-0.30.0-0.30.30.30.10.20.2-0.4
Stereotopy head waving duration, day 70.00.00.10.0-0.0-0.1-0.10.1-0.40.0-0.0-0.0-0.1-0.20.4-0.0
Locomotion velocity, session 81.82.14.6-1.4-1.31.31.3-1.41.7-1.81.40.81.81.1-2.1-0.5
Locomotion distance, session 80.60.92.0-1.1-1.01.11.0-1.11.4-0.90.71.00.81.1-0.6-0.3
Degree of sensitization distance0.20.21.4-0.2-0.20.20.2-0.2-0.2-0.10.10.4-0.60.21.2-0.8
Degree of sensitization stereotypy0.20.31.40.20.2-0.3-0.30.3-0.60.6-0.5-0.0-0.8-0.31.20.4
Conditioned locomotion2.93.44.3-1.9-1.91.91.9-1.92.1-1.81.91.81.91.9-1.4-1.6
Cocaine response after cond. corrected1.92.23.61.81.7-1.7-1.71.7-1.21.9-1.5-1.3-0.7-1.0-0.11.6
Cocaine response after cond. not corrected2.83.14.32.12.1-2.1-2.12.1-1.52.0-1.7-1.8-0.9-1.4-0.31.8
Cocaine response before conditioning0.10.20.60.30.4-0.4-0.40.4-0.4-0.2-0.2-0.7-0.4-0.80.00.3
Saline control response3.03.95.5-2.2-2.22.22.2-2.21.8-2.32.11.81.51.6-0.5-2.2
Bone: connectivity density0.50.71.6-0.8-0.80.80.8-0.80.7-0.91.00.70.90.8-0.7-1.3
Bone: cortical apparent density0.81.13.80.80.8-0.7-0.70.7-1.01.5-1.1-0.2-1.4-0.42.00.5
Bone: cortical area1.92.93.5-1.7-1.81.81.8-1.81.8-1.71.81.61.91.7-1.4-1.4
Bone: cortical porosity1.41.62.81.51.4-1.4-1.41.4-0.80.7-1.0-1.7-0.3-1.3-1.11.6
Bone: cortical porosity0.40.41.80.60.5-0.5-0.50.50.0-0.1-0.2-0.90.4-0.6-1.30.8
Bone: cortical thickness1.22.02.7-1.4-1.41.41.4-1.41.6-1.51.41.21.71.3-1.5-1.0
Bone: cortical thickness0.10.10.60.30.3-0.3-0.30.30.10.7-0.10.20.40.5-0.5-0.1
Bone: cortical tissue density0.81.13.60.80.8-0.8-0.80.8-1.01.5-1.1-0.2-1.4-0.51.90.5
Condit. Reinf. active minus inactive responses0.50.64.9-0.1-0.00.10.1-0.1-0.60.3-0.40.2-1.3-0.42.2-0.0
Condit. Reinf. active-inactive response ratio0.50.60.9-0.9-0.90.90.9-1.00.5-0.60.60.90.20.60.6-0.6
Condit. Reinf. active responses1.31.510.50.30.4-0.3-0.30.3-1.30.9-1.0-0.1-2.1-0.83.20.3
Condit. Reinf. inactive responses1.51.87.50.80.9-0.8-0.80.8-1.41.3-1.4-0.6-2.1-1.02.70.9
Incentive salience index mean1.21.57.50.60.7-0.6-0.60.6-1.40.9-1.0-0.5-2.0-1.12.70.5
Condit. Reinf. lever presses1.01.35.00.70.9-0.7-0.70.7-1.40.7-0.9-0.8-1.8-1.22.20.4
Condit. Reinf. active minus inactive responses1.82.24.4-1.7-1.61.61.6-1.61.1-1.11.41.90.61.60.7-2.1
Condit. Reinf. active-inactive response ratio1.21.32.6-1.2-1.21.21.2-1.20.8-0.71.01.50.41.30.6-1.6
Condit. Reinf. active responses2.43.35.7-2.1-2.02.02.0-2.01.4-1.41.72.30.81.90.7-2.4
Condit. Reinf. inactive responses1.41.72.7-1.5-1.51.51.5-1.50.9-1.21.31.50.61.20.5-1.6
Condit. Reinf. lever presses0.91.22.6-1.3-1.21.21.2-1.20.5-1.11.21.20.40.90.6-1.6
Condit. Reinf. lever reinforcers received2.02.95.5-1.9-1.91.91.9-1.91.1-1.41.62.10.61.70.9-2.3
Conditioned reinforcement - actives0.10.10.30.0-0.1-0.1-0.10.1-0.3-0.50.1-0.3-0.1-0.40.1-0.2
Conditioned reinforcement - inactives0.10.10.3-0.3-0.40.20.2-0.20.3-0.10.00.50.10.50.2-0.1
Conditioned locomotion0.20.20.90.20.1-0.3-0.30.2-0.6-0.7-0.0-0.8-0.3-0.90.10.1
Patch foraging indifference point 0 sec1.42.35.6-1.7-1.61.61.5-1.51.0-2.41.81.01.60.8-1.1-1.5
Patch foraging indifference point AUC2.52.94.51.61.8-1.5-1.51.5-1.71.8-1.8-1.4-2.1-1.72.01.6
Delay disc. indifference point, 0s delay0.20.20.90.20.3-0.3-0.30.3-0.6-0.2-0.1-0.9-0.1-0.9-0.30.4
Delay disc. indifference point, 16s delay0.50.52.50.50.5-0.5-0.50.5-0.20.2-0.1-1.00.6-0.7-1.60.7
Delay disc. indifference point, 2s delay0.70.81.1-1.1-1.01.01.0-1.00.9-0.90.81.00.70.9-0.2-0.6
Delay disc. indifference point, 24s delay1.61.62.71.41.4-1.3-1.31.3-1.31.0-1.1-1.6-0.9-1.60.11.2
Delay disc. indifference point, 4s delay0.40.42.9-0.3-0.30.30.3-0.30.4-0.80.6-0.41.0-0.1-1.7-0.1
Delay disc. indifference point, 8s delay2.42.59.8-1.1-1.21.21.2-1.21.4-1.71.70.32.40.8-3.1-1.0
Indifference point function ln k4.05.57.9-2.2-2.42.22.2-2.22.7-2.22.42.12.82.5-2.6-2.0
Indifference point function log k4.05.57.9-2.2-2.42.22.2-2.22.7-2.22.42.12.82.5-2.6-2.0
Patch foraging total patch changes 0 sec1.21.94.5-1.6-1.51.41.4-1.40.8-2.11.60.91.40.8-0.9-1.4
Patch foraging total patch changes 12 sec0.20.21.6-0.3-0.00.30.3-0.3-0.3-0.30.0-0.0-0.7-0.41.3-0.1
Patch foraging total patch changes 18 sec0.50.72.10.40.7-0.5-0.50.5-1.00.5-0.8-0.6-1.2-1.01.40.6
Patch foraging total patch changes 24 sec1.01.22.8-1.1-0.71.01.0-1.00.7-1.51.40.61.20.7-1.0-1.7
Patch foraging total patch changes 6 sec0.10.20.90.00.2-0.1-0.10.1-0.6-0.1-0.3-0.2-0.6-0.51.00.4
Patch foraging time to switch 0 sec0.30.42.00.50.4-0.4-0.40.4-1.00.3-0.5-0.4-1.0-0.71.40.0
Patch foraging water rate 0 sec0.91.52.3-1.4-1.31.31.3-1.31.5-0.81.11.51.21.5-0.7-0.9
Patch foraging water rate 12 sec0.20.21.1-0.2-0.20.10.1-0.10.60.7-0.00.80.61.0-0.5-0.0
Patch foraging water rate 18 sec0.50.63.0-0.5-0.50.40.3-0.30.9-0.20.50.61.41.0-1.7-0.1
Patch foraging water rate 24 sec0.71.02.6-1.1-1.11.01.1-1.11.20.00.51.60.71.60.1-0.5
Patch foraging water rate 6 sec0.40.62.30.60.5-0.6-0.60.6-0.41.5-1.00.2-0.70.21.00.7
Seeking ratio, delayed vs. immediate footshock1.11.32.7-1.1-1.21.21.3-1.21.2-0.70.91.70.51.50.4-1.0
Distance traveled before self-admin0.20.20.6-0.4-0.50.50.5-0.40.4-0.50.60.40.50.4-0.4-0.7
Distance traveled after self-admin0.20.20.5-0.3-0.20.30.3-0.20.30.30.30.70.20.70.3-0.7
Extensor digitorum longus weight0.20.71.5-0.7-0.80.80.8-0.81.1-0.80.80.61.20.8-1.2-0.2
Bone: elastic displacement0.10.10.40.40.3-0.3-0.30.3-0.3-0.0-0.3-0.5-0.2-0.60.00.6
Bone: elastic work0.50.60.9-0.9-0.90.91.0-1.00.7-0.90.90.70.70.6-0.3-0.6
Bone: endosteal estimation0.00.10.3-0.3-0.30.30.3-0.30.40.10.20.50.30.6-0.1-0.3
Bone: endosteal perimeter0.00.00.0-0.1-0.10.10.0-0.00.10.1-0.00.20.00.20.1-0.0
Epididymis fat weight0.71.62.3-1.4-1.51.41.4-1.41.3-1.41.31.21.21.2-0.8-1.0
Delta time in closed arm before/after self-admin0.10.10.7-0.3-0.40.30.3-0.30.3-0.1-0.10.3-0.40.10.80.3
Delta time in open arm before/after self-admin2.01.93.7-1.3-1.41.31.4-1.41.7-0.71.21.71.41.9-0.9-1.2
Diff in mean of infusions in LGA sessions0.10.10.9-0.2-0.30.30.4-0.40.1-0.00.10.4-0.40.20.9-0.2
Delay discount exponential model param0.60.64.50.30.3-0.3-0.30.3-0.60.7-0.70.4-1.3-0.02.10.2
Extinction: sum of active levers before priming1.21.21.61.31.1-1.2-1.21.2-1.11.1-1.0-1.2-0.8-1.10.31.1
Active lever presses in extinction session 60.10.10.70.40.3-0.3-0.30.4-0.0-0.0-0.1-0.60.2-0.4-0.80.3
Bone: final force1.21.92.9-1.7-1.61.71.7-1.71.6-1.01.11.70.81.50.1-0.8
Bone: final moment0.91.52.2-1.5-1.51.51.5-1.51.4-0.90.91.50.71.30.1-0.6
Food consumed during 24 hour testing period0.10.10.30.40.4-0.4-0.40.4-0.00.5-0.3-0.1-0.00.0-0.20.1
Glucose0.81.22.1-1.2-1.31.21.2-1.21.4-0.80.81.31.01.3-0.6-0.4
Heart weight7.911.213.0-3.6-3.43.63.6-3.63.5-3.33.53.33.13.3-2.0-3.5
Delay discount hyperbolic model param0.70.84.40.50.5-0.5-0.50.5-0.81.0-0.90.1-1.4-0.22.10.3
Intermittent access intake day 1-15 change0.10.10.5-0.1-0.10.00.00.00.60.3-0.00.40.50.7-0.70.1
Intermittent access intake escalation0.10.10.4-0.0-0.0-0.1-0.10.10.40.5-0.20.40.30.6-0.30.2
Intermittent access intake escalation 20.60.61.30.70.7-0.8-0.90.90.11.1-0.8-0.40.20.1-1.01.0
Intermitt. access day 1 inactive lever presses0.70.71.6-1.0-1.00.90.9-0.90.5-1.30.90.70.40.50.1-1.2
Intermitt. access day 15 inactive lever presses0.10.10.7-0.2-0.30.30.3-0.30.1-0.1-0.10.3-0.50.10.80.1
Intermitt. access escalation Index0.10.10.3-0.4-0.30.40.4-0.30.1-0.10.20.5-0.00.30.6-0.3
Intermittent access day 1 total infusions0.10.11.10.1-0.1-0.00.0-0.0-0.4-0.2-0.10.0-0.6-0.31.0-0.0
Intermittent access day 15 total infusions0.00.00.2-0.0-0.20.00.00.0-0.00.1-0.20.3-0.20.20.50.1
Intermittent access terminal intake (last 3 days)0.00.00.2-0.1-0.20.00.0-0.00.30.2-0.10.40.10.50.00.1
Intermittent access total infusions0.00.00.1-0.2-0.30.20.2-0.10.0-0.30.10.3-0.10.20.4-0.2
Intermittent access day 1 locomotion0.50.51.8-0.7-0.90.80.8-0.80.3-1.30.90.30.40.1-0.1-0.8
Intermittent access day 15 total locomotion0.60.71.2-0.7-0.90.80.9-0.90.8-0.70.71.10.41.00.1-1.0
Intermittent access total locomotion0.10.10.2-0.1-0.30.20.2-0.20.0-0.40.20.2-0.10.10.4-0.3
Intermittent access standard deviation0.10.10.4-0.2-0.30.0-0.00.00.30.00.00.50.40.7-0.4-0.3
Left kidney weight2.36.611.4-2.6-2.52.52.4-2.42.8-3.42.71.73.01.9-3.1-1.8
Right kidney weight3.49.517.1-2.9-2.92.92.9-2.93.2-4.13.41.73.62.1-4.0-2.4
Cocaine induced anxiety0.50.62.1-0.7-0.80.80.8-0.80.8-1.40.80.10.70.1-0.9-0.4
Post-drug Anxiety0.30.41.0-0.6-0.60.50.5-0.50.7-0.80.60.30.80.5-1.0-0.4
Baseline Anxiety0.20.20.5-0.4-0.40.30.3-0.30.40.10.20.70.50.7-0.3-0.3
Tail length0.31.01.9-1.0-0.91.11.1-1.11.4-0.70.91.10.81.2-0.5-0.9
Length with tail1.03.64.1-2.0-2.01.91.9-1.92.0-2.02.01.81.81.9-1.2-2.0
Length without tail0.91.93.3-1.4-1.61.41.3-1.41.0-1.61.61.41.31.3-0.6-1.8
Times rat made contact with spout0.30.30.6-0.6-0.60.60.6-0.60.6-0.80.60.30.70.3-0.6-0.3
Lifetime Intake0.10.10.30.30.2-0.3-0.40.4-0.50.1-0.3-0.2-0.4-0.30.50.1
Liver weight, left3.35.37.9-2.1-2.12.12.0-2.02.4-1.82.42.42.62.8-2.2-2.8
Liver weight, right1.32.14.4-1.2-1.31.21.2-1.21.4-1.81.60.81.91.1-2.1-1.4
Locomotor activity0.30.40.70.80.7-0.7-0.70.7-0.80.4-0.5-0.8-0.5-0.80.20.2
Locomotor testing distance0.60.91.41.11.0-1.0-1.01.0-1.00.7-0.9-1.1-0.9-1.20.60.9
Locomotor testing rearing1.21.83.01.31.1-1.2-1.21.2-1.41.3-1.4-1.1-1.7-1.31.71.2
Locomotion in novel chamber0.80.91.4-1.0-1.21.01.0-1.11.0-1.11.00.81.00.8-0.8-0.6
Locomotion in novel chamber post-restriction1.72.13.4-1.3-1.21.21.3-1.21.4-1.01.61.61.61.8-1.3-1.8
Fecal boli incidents, locomotor time 11.41.52.31.31.3-1.4-1.41.4-1.21.2-1.2-1.5-0.8-1.40.01.2
Change in fecal boli incidents, locomotor task4.13.94.8-2.0-2.12.12.1-2.12.2-2.02.02.01.92.1-1.3-1.9
Time >=10cm from walls, locomotor time 10.00.00.20.10.1-0.1-0.10.1-0.10.3-0.20.3-0.20.30.40.0
Bouts of movement, locomotor time 14.54.95.82.42.3-2.4-2.42.4-2.42.3-2.1-2.4-1.9-2.31.11.9
Total resting periods, locomotor time 14.24.65.52.22.2-2.2-2.32.3-2.32.2-2.1-2.2-2.1-2.21.41.9
Rest time, locomotor task time 10.00.00.1-0.2-0.10.20.2-0.20.0-0.20.10.1-0.10.00.2-0.1
Distance moved, locomotor task time 10.20.20.50.40.4-0.3-0.20.2-0.40.4-0.4-0.3-0.6-0.50.70.4
Vertical activity count, locomotor time 10.20.20.5-0.2-0.30.30.4-0.40.3-0.10.50.70.30.60.1-0.7
Time >=10cm from walls, locomotor time 212.613.316.5-3.8-3.83.73.7-3.73.4-4.04.03.63.53.6-2.3-4.1
Bouts of movement, locomotor time 20.20.21.1-0.4-0.30.20.1-0.1-0.00.10.40.70.30.70.2-1.1
Total resting periods, locomotor time 20.10.20.9-0.3-0.10.10.0-0.0-0.10.20.30.70.20.60.3-0.9
Rest time, locomotor task time 24.95.76.82.32.5-2.3-2.32.3-2.32.5-2.6-2.3-2.6-2.41.92.6
Distance moved, locomotor task time 22.42.84.0-1.8-1.81.81.8-1.81.5-2.01.81.51.51.4-0.9-1.6
Vertical activity count, locomotor time 25.86.38.4-2.7-2.82.62.5-2.52.2-2.52.62.92.32.8-1.0-2.7
Light reinforcement 11.32.44.1-2.0-1.81.91.8-1.80.8-2.01.51.40.40.81.0-1.6
Light reinforcement 20.70.92.50.80.7-0.7-0.70.7-1.00.8-0.9-0.8-1.4-1.01.60.8
Bone: marrow area0.10.20.4-0.4-0.30.30.3-0.30.5-0.00.30.60.40.6-0.2-0.3
Bone: maximum diameter1.01.92.4-1.5-1.51.51.5-1.51.4-1.11.41.51.31.5-0.7-1.4
Bone: maximum force2.13.74.7-2.1-2.12.22.2-2.22.1-2.01.91.91.71.8-1.0-1.4
Bone: maximum moment1.62.83.5-1.9-1.91.91.9-1.91.8-1.81.61.61.51.5-0.9-1.2
Mean time between licks in bursts1.11.62.11.41.4-1.4-1.41.4-1.11.2-1.2-1.4-0.9-1.30.21.2
Mean num. licks in bursts0.81.02.2-1.2-1.21.21.2-1.20.8-1.51.10.70.60.5-0.2-0.9
Cd content in liver0.20.20.5-0.4-0.40.30.3-0.30.4-0.40.50.40.70.5-0.7-0.6
Co content in liver0.40.40.80.70.6-0.7-0.70.7-0.40.3-0.5-0.80.1-0.6-0.80.9
Cu content in liver0.50.61.40.80.8-0.9-0.90.9-0.51.2-0.9-0.3-0.5-0.20.20.7
Fe content in liver1.51.89.30.60.6-0.7-0.70.7-1.41.6-1.3-0.2-2.1-0.73.10.5
K content in liver0.20.21.2-0.1-0.10.20.2-0.20.5-0.20.50.30.80.5-1.1-0.4
Mg content in liver0.90.92.2-0.7-0.60.70.7-0.71.3-0.30.71.01.41.3-1.5-0.4
Mn content in liver0.70.81.5-0.8-0.80.90.9-0.91.1-1.21.00.51.10.6-1.2-0.4
Na content in liver1.41.52.41.31.3-1.2-1.21.2-1.21.5-1.3-0.9-1.5-1.01.40.7
Rb content in liver4.55.59.1-2.2-2.12.22.2-2.22.8-2.22.32.13.02.5-3.0-1.5
Se content in liver0.20.20.5-0.5-0.50.50.5-0.50.7-0.30.30.50.50.6-0.4-0.0
Sr content in liver0.50.40.80.70.8-0.8-0.80.8-0.80.1-0.3-0.9-0.1-0.8-0.50.3
Zn content in liver0.40.40.80.80.8-0.8-0.80.8-0.70.9-0.6-0.5-0.7-0.40.40.1
Bone: minimum diameter0.91.75.2-1.0-1.01.01.0-1.01.3-1.71.50.51.90.8-2.3-0.9
Time in familiar zone, hab. session 11.91.82.81.51.5-1.6-1.71.7-1.51.6-1.3-1.2-1.0-1.00.40.8
Time in novel zone, hab. session 13.02.94.4-2.0-1.92.12.1-2.11.9-1.81.61.61.21.4-0.4-1.0
Total zone transitions, hab. session 10.60.81.21.01.1-1.1-1.11.1-1.10.6-0.7-1.1-0.5-0.9-0.10.2
Total locomotion distance, hab. session 10.50.71.20.90.9-1.0-1.01.0-0.90.4-0.5-1.1-0.4-1.0-0.20.3
Locomotion velocity, hab. session 10.81.12.01.21.2-1.2-1.21.3-1.30.5-0.7-1.4-0.7-1.3-0.10.4
Time in familiar zone, hab. session 20.00.00.10.10.2-0.2-0.20.2-0.30.30.00.20.10.20.1-0.4
Time in novel zone, hab. session 20.60.61.1-0.8-0.90.91.0-1.01.0-1.10.70.40.60.4-0.5-0.1
Total zone transitions, hab. session 20.30.40.80.80.8-0.8-0.90.8-0.60.4-0.4-0.9-0.0-0.6-0.80.3
Total locomotion distance, hab. session 20.00.00.10.00.0-0.1-0.10.2-0.1-0.20.1-0.20.1-0.1-0.4-0.2
Locomotion velocity, hab. session 20.10.10.20.30.3-0.3-0.30.4-0.4-0.1-0.1-0.4-0.1-0.3-0.2-0.2
Novel to familiar place preference ratio2.22.33.1-1.6-1.71.71.8-1.71.4-1.71.71.41.11.2-0.4-1.6
Novelty place preference2.12.12.9-1.6-1.71.71.7-1.71.4-1.71.61.31.11.2-0.4-1.5
Time in novel zone, NPP test2.02.12.8-1.6-1.71.71.7-1.71.4-1.61.61.31.01.2-0.3-1.5
Total zone transitions, NPP test1.42.02.91.61.6-1.7-1.71.7-1.11.3-1.3-1.6-0.6-1.3-0.61.4
Total locomotion distance, NPP test0.40.61.40.80.8-0.8-0.80.8-0.30.1-0.5-1.20.0-0.8-1.20.9
Locomotion velocity, NPP test0.60.81.80.90.9-1.0-1.01.0-0.40.2-0.6-1.3-0.0-1.0-1.21.0
Intraocular pressure1.62.23.01.51.4-1.5-1.51.5-1.71.4-1.5-1.4-1.4-1.61.21.5
Delta distance traveled before/after self-admin0.10.20.60.30.4-0.3-0.30.3-0.40.6-0.40.0-0.5-0.10.70.1
Delta ambulatory time before/after self-admin0.20.21.20.20.4-0.2-0.20.3-0.50.4-0.3-0.1-0.8-0.31.10.1
Parametrial fat weight0.10.20.8-0.4-0.30.30.3-0.30.2-0.70.60.20.40.2-0.4-0.9
Pavlov. Cond. lever latency0.20.20.7-0.4-0.50.50.5-0.40.60.10.30.80.50.8-0.2-0.3
Pavlov. Cond. magazine entry latency0.81.01.8-1.2-1.11.21.2-1.30.5-1.30.90.8-0.20.41.1-1.0
Pavlov. Cond. change in total contacts0.20.20.4-0.5-0.40.50.5-0.60.4-0.40.20.4-0.20.30.5-0.2
Pavlov. Cond. index score0.10.20.70.10.2-0.1-0.10.1-0.6-0.2-0.2-0.4-0.7-0.60.8-0.0
Pavlov. Cond. latency score0.10.10.40.10.2-0.1-0.1-0.0-0.5-0.40.0-0.4-0.5-0.60.5-0.2
Pavlov. Cond. lever contacts0.30.30.80.50.6-0.5-0.50.5-0.70.0-0.4-0.8-0.6-0.90.30.3
Pavlov. Cond. magazine entry number0.50.61.20.90.8-0.9-0.91.0-0.41.1-0.6-0.60.1-0.2-0.80.6
Pavlov. Cond. intertrial magazine entries0.30.31.80.50.4-0.5-0.50.5-0.41.3-0.60.2-0.40.20.70.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.30.4-0.3-0.30.2-0.6-0.0-0.3-0.6-0.8-0.70.70.3
Pavlov. Cond. response bias0.10.21.3-0.1-0.00.10.1-0.2-0.3-0.1-0.2-0.1-0.8-0.41.20.1
Pavlov. Cond. lever latency4.46.08.12.82.8-2.8-2.82.8-2.22.5-2.5-2.6-1.7-2.30.22.5
Pavlov. Cond. magazine entry latency1.71.92.9-1.7-1.71.71.7-1.70.9-1.11.01.70.01.21.5-1.2
Pavlov. Cond. change in total contacts1.82.53.8-1.9-1.81.91.9-1.91.2-1.31.31.90.31.51.2-1.8
Pavlov. Cond. index score3.03.85.7-2.4-2.32.32.3-2.31.6-1.61.72.40.61.91.1-1.9
Pavlov. Cond. latency score2.63.24.8-2.2-2.12.12.1-2.11.5-1.51.52.20.51.71.1-1.7
Pavlov. Cond. lever contacts3.34.56.2-2.5-2.42.52.5-2.51.6-2.12.22.31.21.90.3-2.5
Pavlov. Cond. magazine entry number2.02.43.71.91.8-1.9-1.91.9-1.31.2-1.2-1.9-0.3-1.4-1.21.3
Pavlov. Cond. intertrial magazine entries0.30.43.10.30.2-0.2-0.20.20.2-0.20.2-0.40.9-0.1-1.80.2
Pavlov. Cond. lever-magazine prob. diff.2.83.65.3-2.3-2.22.32.3-2.31.5-1.51.62.30.51.81.2-1.8
Pavlov. Cond. response bias4.15.57.7-2.8-2.72.72.7-2.71.8-2.12.22.71.12.20.9-2.6
Time in closed arm before self-admin2.12.43.91.51.6-1.7-1.71.6-2.01.6-1.5-1.4-1.6-1.51.41.1
Time in closed arm after self-admin1.31.34.50.70.9-0.8-0.80.8-1.41.0-1.1-0.6-1.6-1.02.10.9
Time in open arm before self-admin0.40.40.6-0.7-0.50.70.7-0.70.7-0.70.70.50.80.5-0.6-0.4
Time in open arm after self-admin3.33.76.2-1.8-1.91.91.9-1.92.5-1.31.72.02.12.3-1.8-1.5
Bone: periosteal estimation0.81.62.0-1.3-1.31.31.3-1.31.4-1.01.21.31.41.4-1.0-1.0
Bone: periosteal perimeter0.61.01.5-0.9-1.00.90.9-0.91.1-1.11.00.71.20.8-1.2-0.6
Bone: post-yield work0.10.10.30.30.3-0.3-0.30.3-0.0-0.0-0.1-0.40.0-0.2-0.50.2
Progressive ratio test 1 active lever presses0.20.21.2-0.3-0.40.20.2-0.2-0.2-0.30.00.5-0.40.21.1-0.3
Progressive ratio test 1 breakpoint0.10.11.1-0.1-0.20.10.0-0.1-0.2-0.1-0.10.4-0.50.11.1-0.2
Progressive ratio test 1 inactive lever presses0.20.21.8-0.1-0.2-0.0-0.00.1-0.4-0.0-0.40.2-0.8-0.11.4-0.0
Progressive ratio test 2 active lever presses0.30.32.70.1-0.0-0.1-0.10.1-0.40.3-0.50.2-1.0-0.11.60.2
Progressive ratio test 2 breakpoint0.30.43.1-0.2-0.30.30.3-0.3-0.20.0-0.20.6-0.80.21.7-0.1
Progressive ratio test 2 inactive lever presses0.20.20.6-0.4-0.50.50.5-0.50.3-0.30.10.6-0.20.30.8-0.1
Incentive Sensitization - Responses0.10.10.2-0.2-0.30.30.4-0.40.4-0.00.10.40.00.30.20.0
Incentive Sensitization - Breakpoint0.10.10.2-0.3-0.30.40.4-0.40.4-0.10.10.5-0.00.40.4-0.0
Sum of active levers in priming session hrs 5-60.10.10.30.50.3-0.3-0.30.30.00.6-0.4-0.2-0.2-0.1-0.00.4
Progressive ratio0.20.20.50.30.6-0.6-0.70.6-0.70.5-0.3-0.2-0.3-0.20.3-0.5
Food seeking constrained by brief footshock0.00.00.10.00.1-0.0-0.00.0-0.1-0.20.1-0.1-0.0-0.1-0.0-0.2
Seeking ratio, punishment vs. effort0.10.10.40.2-0.10.10.2-0.20.1-0.1-0.1-0.2-0.2-0.30.30.6
Retroperitoneal fat weight4.815.618.4-4.2-4.34.24.2-4.23.8-3.94.14.23.54.1-1.7-4.3
Reaction time number correct3.65.27.5-2.5-2.22.32.2-2.22.6-1.82.12.52.42.7-1.8-2.0
Reaction time mean minus median1.01.31.8-0.8-1.11.21.2-1.21.1-1.11.41.01.21.1-0.8-1.3
Reaction time mean minus median AUC3.03.95.0-1.7-2.02.12.2-2.22.1-2.02.21.72.01.8-1.4-1.9
Reaction time num false alarms0.00.00.2-0.20.10.0-0.00.0-0.1-0.3-0.2-0.1-0.3-0.30.30.4
Reaction time num false alarms AUC0.10.10.60.00.3-0.1-0.10.1-0.30.1-0.4-0.1-0.6-0.30.70.4
Reaction time trials correct on left3.65.27.5-2.5-2.22.32.2-2.22.6-1.82.12.52.42.7-1.8-2.0
Reaction time trials on left3.75.27.5-2.5-2.22.32.2-2.22.6-1.82.12.52.42.7-1.7-2.0
Reaction time mean0.40.62.30.70.6-0.6-0.60.6-0.91.0-0.7-0.1-1.0-0.41.50.3
Reaction time mean AUC0.20.21.10.40.3-0.3-0.30.3-0.50.7-0.40.1-0.6-0.11.00.1
Median of all reaction times1.72.35.11.31.3-1.4-1.41.4-1.71.8-1.6-0.8-1.9-1.12.31.1
Reaction time omissions0.20.31.0-0.6-0.70.70.7-0.70.4-1.00.60.40.40.2-0.1-0.5
Reaction time false alarm rate1.11.52.31.11.2-1.1-1.11.1-1.40.8-1.2-1.2-1.5-1.51.31.2
Reaction time premature initiation rate0.81.14.80.70.7-0.7-0.70.7-1.40.6-0.8-0.5-1.6-0.92.20.0
Reaction time premature initiations0.30.41.4-0.6-0.50.60.5-0.50.1-0.30.30.9-0.30.61.2-0.9
Std. dev. reaction times0.71.01.4-0.8-1.01.11.1-1.10.8-0.91.21.00.90.9-0.4-1.2
Reaction time trials completed3.75.27.5-2.5-2.22.32.2-2.22.6-1.82.12.52.42.7-1.7-2.0
Reaction time trials AUC3.65.27.9-2.5-2.32.32.2-2.22.5-1.72.12.72.32.8-1.4-2.1
Run reversals in cocaine runway, females0.10.10.3-0.1-0.10.10.0-0.00.50.2-0.00.30.20.5-0.4-0.0
Run reversals in cocaine runway, males1.81.72.31.21.5-1.4-1.41.4-1.31.2-1.5-1.2-1.3-1.30.81.4
Latency to leave start box in cocaine runway0.10.20.8-0.4-0.10.10.1-0.1-0.20.00.10.5-0.30.30.9-0.7
Latency to leave start box in cocaine runway, F0.10.20.30.20.5-0.4-0.50.5-0.60.2-0.2-0.6-0.2-0.5-0.00.1
Latency to leave start box in cocaine runway, M1.11.12.6-1.2-1.00.90.9-0.90.5-0.30.51.6-0.31.21.6-1.3
Std. dev. time between licks in bursts1.11.43.2-1.0-1.01.01.0-1.01.2-1.41.30.51.50.8-1.8-0.9
Total sessions with >9 infusions0.30.30.90.50.3-0.5-0.50.5-0.7-0.4-0.1-1.0-0.1-1.0-0.40.3
Short access day 1 total inactive lever presses0.20.30.5-0.5-0.50.50.4-0.40.4-0.60.60.50.60.5-0.5-0.7
Short access day 10 total inactive lever presses1.21.32.0-1.3-1.21.41.4-1.41.4-1.31.01.10.51.0-0.1-0.8
Short access day 1 total infusions1.01.11.71.21.0-1.2-1.21.2-1.30.7-0.9-1.2-0.8-1.20.40.8
Short access day 10 total infusions0.10.10.5-0.2-0.40.20.2-0.2-0.2-0.60.40.20.10.10.2-0.7
Short access total infusions0.20.20.60.50.3-0.6-0.60.6-0.80.2-0.3-0.4-0.3-0.40.2-0.0
Short access day 1 locomotion0.40.41.00.60.5-0.6-0.60.6-1.00.3-0.5-0.6-0.8-0.80.90.3
Short access day 10 total locomotion0.50.62.10.90.7-0.7-0.70.7-0.20.2-0.3-1.10.4-0.7-1.40.7
Short access total locomotion0.10.10.7-0.0-0.20.00.0-0.1-0.3-0.80.4-0.30.2-0.4-0.3-0.3
One hour access (0.3 mA shock)0.20.20.80.1-0.0-0.1-0.10.10.20.7-0.50.6-0.40.60.90.4
Compulsive drug intake0.10.10.50.10.1-0.0-0.00.00.10.7-0.20.5-0.10.50.4-0.1
One hour access (shock baseline)0.10.10.70.0-0.1-0.1-0.10.1-0.3-0.1-0.3-0.0-0.6-0.20.80.3
Social response proportion1.31.44.3-1.2-1.31.21.2-1.20.5-0.60.51.7-0.51.22.1-1.1
Social responses1.01.210.4-0.10.1-0.0-0.10.1-0.90.8-0.80.5-1.8-0.23.20.2
Social time0.20.21.0-0.4-0.30.30.3-0.30.00.20.20.7-0.20.51.0-0.7
Soleus weight0.00.10.9-0.0-0.10.10.1-0.1-0.20.5-0.10.4-0.40.30.9-0.3
Bone: stiffness1.62.53.0-1.7-1.71.71.7-1.71.7-1.61.61.61.31.5-0.8-1.4
Tibialis anterior weight0.31.02.2-1.0-1.11.11.1-1.10.7-0.20.71.50.21.30.9-1.2
Time to tail flick, vehicle, before self-admin0.40.41.5-0.4-0.30.40.4-0.40.5-0.80.80.10.90.3-1.2-0.7
Time to tail flick, vehicle, after self-admin0.20.20.5-0.4-0.50.40.4-0.40.6-0.20.40.50.70.6-0.7-0.2
Time to tail flick, test, before self-admin0.70.71.1-1.0-0.80.90.9-0.90.7-1.00.90.80.60.7-0.2-0.9
Time to tail flick, test, after self-admin0.80.81.2-0.9-0.80.90.9-0.90.9-0.81.00.90.91.0-0.6-1.1
Delta time to tail flick, vehicle, before/after SA0.80.81.5-0.9-1.00.90.9-0.91.1-0.40.61.20.71.2-0.3-0.6
Delta time to tail flick, test, before/after SA0.10.10.1-0.1-0.20.20.2-0.20.2-0.10.30.20.40.2-0.4-0.3
Tibia length0.51.54.6-1.3-1.31.21.2-1.21.0-2.11.40.51.20.5-1.2-1.0
Ambulatory time before self-admin0.20.20.4-0.3-0.40.40.5-0.50.3-0.60.60.10.50.2-0.5-0.5
Ambulatory time after self-admin0.20.20.80.30.4-0.3-0.30.3-0.30.7-0.5-0.0-0.6-0.10.90.3
Bone: tissue strength0.20.20.6-0.5-0.40.50.5-0.50.6-0.80.50.10.50.2-0.7-0.1
Total heroin consumption0.30.31.00.60.5-0.5-0.40.4-0.10.2-0.3-0.90.2-0.6-1.00.7
Bone: trabecular number1.82.83.9-1.6-1.61.61.6-1.62.0-1.31.61.81.82.0-1.5-1.6
Bone: trabecular spacing0.71.01.90.70.8-0.7-0.80.8-1.30.5-0.8-1.0-1.2-1.41.30.9
Bone: trabecular thickness0.30.31.20.70.6-0.6-0.60.6-0.41.1-0.6-0.1-0.40.00.50.2
Bone: trabecular tissue density2.43.45.82.02.1-2.1-2.12.1-1.42.4-2.1-1.5-1.6-1.30.72.0
Water consumed over 24 hours0.10.10.5-0.1-0.10.10.1-0.1-0.00.2-0.20.2-0.30.10.70.1
Number of responses in last shaping day0.40.40.90.60.5-0.6-0.60.6-0.90.3-0.4-0.7-0.6-0.80.50.4