Hub : Genes

Ehd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ehd3 0.17 0.07 2.8e-13 0.15 0.13 0.13 0.14 1.1e-16 6.5e-15 2.7e-15 2.3e-16
2 PL gene expression Ehd3 0.12 0.06 7.1e-08 0.1 0.07 0.08 0.1 1.6e-11 1.3e-08 3.9e-09 1.3e-11
3 OFC gene expression Ehd3 0.49 0.15 2.4e-06 0.24 0.11 0.06 0.19 2.6e-06 1.4e-03 1.3e-02 2.3e-05
4 Brain gene expression Ehd3 0.21 0.09 9.0e-10 0.14 0.11 0.13 0.13 1.5e-12 2.0e-10 7.7e-12 5.0e-12
5 Adipose gene expression Ehd3 0.25 0.09 3.3e-13 0.12 0.1 0.1 0.11 1.1e-12 4.9e-11 2.7e-11 4.3e-12
6 pVTA gene expression Ehd3 0.2 0.09 5.9e-05 0.08 0.11 0.04 0.09 2.1e-04 1.9e-05 1.0e-02 1.3e-04
7 IL mRNA stability Ehd3 0.24 0.13 7.3e-03 0.04 0.1 0.03 0.05 3.3e-02 2.8e-03 8.5e-02 2.3e-02
8 BLA gene expression Ehd3 0.1 0.05 3.4e-04 0.03 0.05 0.04 0.05 7.4e-03 1.3e-03 4.5e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density5.38.912.03.1-3.43.53.4-3.4-2.6-2.3-1.8
Area under the delay curve2.12.24.01.4-1.51.51.5-1.5-1.5-2.0-0.7
BMI with tail0.20.75.1-0.30.2-0.1-0.20.2-0.32.30.1
BMI without tail0.30.63.5-0.70.4-0.3-0.40.40.01.9-0.1
Body weight0.93.712.3-1.91.7-1.5-1.51.51.53.51.2
Weight adjusted by age0.60.61.30.7-0.80.70.7-0.7-1.1-1.1-0.1
Bone surface2.34.15.42.1-2.32.32.3-2.3-1.5-1.8-1.4
Bone volume2.64.45.92.1-2.42.42.4-2.4-1.4-1.8-1.5
Breakpoint value in progressive ratio session0.30.30.90.7-0.40.10.2-0.2-0.30.8-0.9
Number of licking bursts0.20.21.4-0.10.0-0.00.0-0.0-0.11.20.5
Context. condit. distance diff. score0.40.50.8-0.80.6-0.5-0.60.60.90.70.8
Locomotion velocity, session 10.50.61.60.6-0.60.60.6-0.6-0.9-0.1-1.3
Locomotion distance, session 10.60.72.51.0-0.70.60.6-0.6-1.6-0.7-0.6
Locomotion velocity, session 20.50.50.70.8-0.70.70.6-0.6-0.8-0.8-0.7
Locomotion distance, session 20.20.21.00.5-0.40.40.3-0.3-1.00.3-0.4
Locomotion velocity, session 32.83.34.01.7-1.92.02.0-2.0-1.9-1.6-1.3
Locomotion distance, session 32.02.22.71.6-1.71.61.6-1.6-1.6-0.1-1.4
Stereotopy head waving bouts, day 32.22.63.31.5-1.71.81.8-1.8-1.0-1.6-1.6
Stereotopy head waving duration, day 30.80.91.40.9-1.01.01.0-1.0-0.5-1.2-0.9
Locomotion velocity, session 72.42.75.51.6-1.71.81.7-1.7-2.40.7-0.8
Locomotion distance, session 70.30.31.10.3-0.40.60.5-0.5-1.00.60.4
Stereotopy head waving bouts, day 70.10.10.70.1-0.20.20.1-0.10.1-0.90.0
Stereotopy head waving duration, day 70.91.13.40.9-0.90.90.9-0.9-0.8-1.9-0.8
Locomotion velocity, session 81.41.72.71.4-1.31.31.2-1.2-1.60.2-1.6
Locomotion distance, session 80.10.10.6-0.1-0.00.1-0.10.1-0.40.80.4
Degree of sensitization distance1.41.43.3-1.41.2-1.0-1.11.10.70.81.8
Degree of sensitization stereotypy0.10.10.4-0.20.3-0.4-0.40.40.1-0.40.7
Conditioned locomotion2.63.04.62.2-1.91.81.9-1.9-1.9-1.3-0.5
Cocaine response after cond. corrected1.01.22.51.1-0.90.70.9-0.9-1.4-1.6-0.7
Cocaine response after cond. not corrected1.51.72.71.4-1.21.11.2-1.2-1.6-1.5-1.1
Cocaine response before conditioning0.60.71.31.0-1.01.00.9-0.9-0.3-0.1-1.1
Saline control response1.21.53.41.4-1.41.31.2-1.2-0.10.3-1.8
Bone: connectivity density6.19.612.63.1-3.53.53.4-3.4-3.0-2.6-1.9
Bone: cortical apparent density0.30.31.70.8-0.40.20.3-0.3-0.20.1-1.3
Bone: cortical area0.00.10.20.4-0.20.20.3-0.3-0.10.2-0.0
Bone: cortical porosity1.41.69.40.0-0.20.40.4-0.4-1.0-3.11.2
Bone: cortical porosity1.31.48.5-0.2-0.00.20.2-0.2-0.9-2.91.3
Bone: cortical thickness0.20.40.6-0.40.6-0.7-0.60.60.60.50.8
Bone: cortical thickness0.30.41.10.5-0.40.30.4-0.4-1.0-0.90.6
Bone: cortical tissue density0.20.31.70.7-0.30.20.2-0.2-0.10.1-1.3
Condit. Reinf. active minus inactive responses1.31.44.1-1.41.2-1.1-0.90.90.42.00.8
Condit. Reinf. active-inactive response ratio0.20.21.2-0.50.5-0.4-0.20.20.11.1-0.1
Condit. Reinf. active responses0.50.62.0-0.90.6-0.5-0.40.4-0.51.40.9
Condit. Reinf. inactive responses0.20.20.7-0.20.00.0-0.10.1-0.80.00.9
Incentive salience index mean0.30.31.0-0.80.5-0.3-0.20.2-0.41.00.7
Condit. Reinf. lever presses0.20.31.20.0-0.20.30.4-0.4-1.1-0.60.7
Condit. Reinf. active minus inactive responses0.10.10.30.3-0.20.20.1-0.1-0.50.40.2
Condit. Reinf. active-inactive response ratio0.10.10.30.3-0.20.20.1-0.1-0.6-0.10.4
Condit. Reinf. active responses0.00.00.2-0.00.1-0.1-0.20.2-0.00.40.1
Condit. Reinf. inactive responses0.00.00.00.1-0.10.10.1-0.1-0.10.2-0.1
Condit. Reinf. lever presses0.10.21.20.3-0.10.10.1-0.1-0.51.10.0
Condit. Reinf. lever reinforcers received0.10.10.3-0.10.2-0.2-0.30.3-0.20.60.1
Conditioned reinforcement - actives0.90.92.10.9-1.01.01.0-1.00.21.4-0.5
Conditioned reinforcement - inactives0.70.82.90.4-0.50.40.4-0.40.11.7-1.6
Conditioned locomotion0.91.13.81.3-0.80.60.6-0.60.41.2-1.9
Patch foraging indifference point 0 sec0.10.21.30.2-0.20.30.3-0.3-0.2-1.1-0.4
Patch foraging indifference point AUC1.01.22.01.0-1.31.41.3-1.3-0.70.5-0.9
Delay disc. indifference point, 0s delay1.11.21.7-1.21.2-1.2-1.21.20.5-0.81.3
Delay disc. indifference point, 16s delay2.42.45.21.4-1.61.51.5-1.5-1.6-2.3-0.5
Delay disc. indifference point, 2s delay1.21.44.20.9-1.01.11.1-1.1-1.1-2.0-0.2
Delay disc. indifference point, 24s delay5.45.26.52.2-2.62.52.5-2.5-2.3-2.2-1.1
Delay disc. indifference point, 4s delay1.31.45.50.3-0.81.01.0-1.0-1.1-2.3-0.6
Delay disc. indifference point, 8s delay2.12.22.71.6-1.61.51.5-1.5-1.7-1.3-0.8
Indifference point function ln k0.40.51.4-0.70.7-0.7-0.60.60.2-1.20.8
Indifference point function log k0.40.51.4-0.70.7-0.7-0.60.60.2-1.20.8
Patch foraging total patch changes 0 sec0.00.10.5-0.10.1-0.00.0-0.0-0.2-0.7-0.1
Patch foraging total patch changes 12 sec0.00.00.10.2-0.20.20.2-0.2-0.30.20.1
Patch foraging total patch changes 18 sec0.40.61.90.6-0.70.80.7-0.7-0.2-0.0-1.4
Patch foraging total patch changes 24 sec0.10.10.6-0.40.1-0.1-0.00.00.8-0.2-0.1
Patch foraging total patch changes 6 sec0.10.20.30.5-0.40.50.4-0.4-0.5-0.30.2
Patch foraging time to switch 0 sec1.01.52.01.3-1.31.31.3-1.3-1.4-0.5-1.1
Patch foraging water rate 0 sec0.30.41.0-0.50.7-0.7-0.60.60.4-0.61.0
Patch foraging water rate 12 sec2.84.36.3-2.02.4-2.5-2.52.51.4-0.51.8
Patch foraging water rate 18 sec0.81.01.8-0.81.1-1.1-1.01.01.1-0.11.3
Patch foraging water rate 24 sec1.11.52.1-1.21.3-1.3-1.21.21.30.91.5
Patch foraging water rate 6 sec0.71.01.3-1.11.1-1.1-1.01.00.8-0.91.1
Seeking ratio, delayed vs. immediate footshock0.40.42.70.1-0.20.1-0.00.00.80.5-1.6
Distance traveled before self-admin1.31.42.5-1.01.1-1.1-1.21.21.11.60.9
Distance traveled after self-admin1.51.62.1-1.21.2-1.3-1.31.31.01.31.5
Extensor digitorum longus weight2.610.212.93.6-3.63.53.5-3.5-3.20.1-3.0
Bone: elastic displacement0.20.20.4-0.0-0.30.50.5-0.5-0.5-0.10.6
Bone: elastic work0.70.91.50.7-1.01.11.1-1.1-1.2-0.50.3
Bone: endosteal estimation0.20.40.50.5-0.70.70.7-0.7-0.6-0.4-0.6
Bone: endosteal perimeter0.10.10.40.3-0.30.30.3-0.30.30.1-0.7
Epididymis fat weight3.58.212.9-3.23.0-2.8-2.82.83.62.02.4
Delta time in closed arm before/after self-admin0.30.32.1-0.10.2-0.1-0.00.0-0.4-1.50.6
Delta time in open arm before/after self-admin0.90.94.40.7-0.80.70.7-0.7-0.3-0.1-2.1
Diff in mean of infusions in LGA sessions0.10.10.40.3-0.1-0.1-0.00.00.20.4-0.7
Delay discount exponential model param2.72.94.5-1.61.8-1.7-1.71.71.82.10.8
Extinction: sum of active levers before priming0.40.41.7-0.70.5-0.4-0.30.3-0.30.61.3
Active lever presses in extinction session 60.20.21.0-0.4-0.00.20.3-0.31.0-0.30.1
Bone: final force0.71.13.30.7-0.91.01.0-1.0-0.9-1.8-0.2
Bone: final moment0.61.02.70.7-0.91.00.9-0.9-1.0-1.7-0.2
Food consumed during 24 hour testing period0.10.20.3-0.20.5-0.5-0.50.50.4-0.30.4
Glucose0.91.42.6-0.91.2-1.3-1.21.21.61.10.1
Heart weight4.25.98.2-2.92.8-2.7-2.72.72.80.61.2
Delay discount hyperbolic model param2.62.74.4-1.51.7-1.7-1.71.71.72.10.8
Intermittent access intake day 1-15 change1.21.21.6-1.31.2-1.2-1.21.20.8-0.21.3
Intermittent access intake escalation1.31.32.5-1.41.2-1.1-1.11.10.8-0.41.6
Intermittent access intake escalation 23.53.45.1-2.22.0-2.0-1.91.91.71.01.8
Intermitt. access day 1 inactive lever presses0.20.20.70.10.1-0.2-0.20.20.40.6-0.9
Intermitt. access day 15 inactive lever presses0.20.31.40.10.0-0.0-0.00.00.70.5-1.2
Intermitt. access escalation Index0.20.20.40.2-0.40.60.6-0.6-0.30.60.4
Intermittent access day 1 total infusions2.52.95.32.3-1.81.41.4-1.4-1.91.4-1.9
Intermittent access day 15 total infusions0.30.31.00.7-0.50.30.3-0.3-1.00.7-0.5
Intermittent access terminal intake (last 3 days)0.60.71.80.9-0.80.50.5-0.5-0.71.4-1.0
Intermittent access total infusions1.21.32.21.5-1.20.90.9-0.9-1.21.1-1.4
Intermittent access day 1 locomotion2.32.46.52.0-1.30.90.9-0.9-1.01.9-2.6
Intermittent access day 15 total locomotion2.02.14.12.0-1.61.31.3-1.3-0.91.0-1.9
Intermittent access total locomotion1.01.23.51.4-0.80.30.3-0.3-0.41.7-1.9
Intermittent access standard deviation0.40.40.6-0.70.7-0.6-0.60.60.70.6-0.2
Left kidney weight0.10.30.50.3-0.50.60.6-0.60.7-0.2-0.2
Right kidney weight0.51.53.4-1.01.0-0.9-1.01.01.81.41.2
Cocaine induced anxiety0.40.40.70.7-0.70.70.7-0.7-0.10.6-0.9
Post-drug Anxiety0.10.10.30.0-0.20.10.1-0.10.2-0.2-0.6
Baseline Anxiety0.20.20.6-0.1-0.20.40.4-0.4-0.2-0.80.3
Tail length0.51.43.0-1.61.3-1.1-1.11.11.70.60.6
Length with tail1.34.76.3-2.52.3-2.1-2.12.12.51.81.9
Length without tail0.20.40.9-0.60.6-0.5-0.40.40.80.50.9
Times rat made contact with spout3.54.05.22.1-2.22.32.3-2.3-1.2-2.0-1.3
Lifetime Intake1.71.92.81.7-1.41.21.2-1.2-1.51.0-1.6
Liver weight, left1.52.42.7-1.51.6-1.6-1.61.61.51.61.2
Liver weight, right5.38.810.3-3.03.2-3.2-3.23.23.12.22.6
Locomotor activity0.10.10.5-0.50.2-0.1-0.10.1-0.5-0.70.2
Locomotor testing distance0.30.51.10.3-0.50.60.6-0.6-1.0-1.0-0.6
Locomotor testing rearing0.20.31.10.4-0.40.40.5-0.5-0.70.3-1.1
Locomotion in novel chamber0.40.50.9-0.50.7-0.9-0.80.80.90.4-0.5
Locomotion in novel chamber post-restriction3.13.86.1-1.92.3-2.5-2.42.41.30.61.1
Fecal boli incidents, locomotor time 10.60.63.0-0.30.4-0.4-0.40.4-0.4-1.71.0
Change in fecal boli incidents, locomotor task3.33.15.4-1.91.7-1.5-1.51.52.02.31.4
Time >=10cm from walls, locomotor time 13.63.69.1-2.02.0-2.0-2.02.00.10.03.0
Bouts of movement, locomotor time 10.80.82.71.0-0.90.80.8-0.8-1.60.10.1
Total resting periods, locomotor time 10.80.93.20.8-0.90.90.9-0.9-1.8-0.60.2
Rest time, locomotor task time 10.30.31.3-0.40.10.00.0-0.0-0.9-1.10.6
Distance moved, locomotor task time 10.30.31.3-0.00.4-0.5-0.50.50.71.2-0.2
Vertical activity count, locomotor time 10.20.20.6-0.00.2-0.3-0.30.30.60.80.3
Time >=10cm from walls, locomotor time 21.01.11.8-1.01.2-1.2-1.21.21.30.00.5
Bouts of movement, locomotor time 21.71.85.5-1.41.3-1.2-1.21.20.40.72.3
Total resting periods, locomotor time 21.41.54.0-1.21.2-1.1-1.11.10.41.12.0
Rest time, locomotor task time 20.60.71.20.9-0.90.90.9-0.9-0.9-0.0-1.1
Distance moved, locomotor task time 20.20.30.8-0.10.3-0.4-0.40.40.90.8-0.3
Vertical activity count, locomotor time 20.20.20.80.10.1-0.1-0.20.20.8-0.9-0.2
Light reinforcement 12.85.18.83.0-2.42.12.1-2.1-2.10.5-2.8
Light reinforcement 20.81.02.21.5-1.10.90.9-0.9-1.30.4-0.7
Bone: marrow area0.20.40.50.5-0.70.70.6-0.6-0.6-0.3-0.6
Bone: maximum diameter0.40.71.41.2-0.90.70.7-0.7-0.6-0.2-1.2
Bone: maximum force0.00.00.2-0.20.10.00.1-0.1-0.1-0.20.4
Bone: maximum moment0.00.00.2-0.30.1-0.0-0.00.0-0.2-0.10.4
Mean time between licks in bursts0.30.41.7-0.80.6-0.5-0.40.40.20.21.3
Mean num. licks in bursts2.83.36.91.7-1.81.81.8-1.8-0.7-2.6-1.8
Cd content in liver0.20.30.8-0.60.4-0.3-0.30.30.4-0.50.9
Co content in liver1.61.94.81.5-1.31.11.2-1.2-2.2-1.50.3
Cu content in liver0.20.30.70.8-0.60.50.5-0.5-0.6-0.10.0
Fe content in liver0.40.42.70.1-0.20.30.3-0.30.3-1.7-0.5
K content in liver0.10.10.40.3-0.20.10.0-0.00.40.6-0.7
Mg content in liver1.92.06.21.6-1.41.31.3-1.3-0.5-0.1-2.5
Mn content in liver1.72.03.21.8-1.61.51.5-1.5-0.7-0.7-1.6
Na content in liver0.70.71.30.8-0.90.91.0-1.00.60.1-1.2
Rb content in liver1.11.32.21.5-1.21.11.0-1.0-1.1-0.8-1.3
Se content in liver0.10.20.70.1-0.10.0-0.00.00.50.5-0.8
Sr content in liver1.61.54.0-1.41.0-0.8-0.80.81.32.01.2
Zn content in liver0.30.31.40.1-0.0-0.1-0.10.10.51.2-0.7
Bone: minimum diameter0.10.10.20.2-0.40.40.5-0.5-0.1-0.4-0.3
Time in familiar zone, hab. session 10.10.10.3-0.20.2-0.1-0.10.10.1-0.5-0.6
Time in novel zone, hab. session 10.90.81.1-0.91.0-1.0-1.01.00.61.00.6
Total zone transitions, hab. session 10.30.40.6-0.80.7-0.7-0.70.70.5-0.4-0.0
Total locomotion distance, hab. session 10.30.40.7-0.70.6-0.6-0.60.60.80.0-0.6
Locomotion velocity, hab. session 10.10.20.4-0.50.3-0.2-0.20.20.60.5-0.4
Time in familiar zone, hab. session 22.22.33.21.2-1.61.81.7-1.7-1.1-1.4-1.4
Time in novel zone, hab. session 22.22.23.1-1.31.6-1.7-1.61.61.21.51.0
Total zone transitions, hab. session 20.40.51.60.5-0.50.50.5-0.5-0.8-1.3-0.6
Total locomotion distance, hab. session 20.10.10.6-0.1-0.20.30.3-0.30.1-0.1-0.8
Locomotion velocity, hab. session 20.10.20.50.0-0.30.50.5-0.5-0.2-0.2-0.7
Novel to familiar place preference ratio1.92.02.6-1.31.5-1.6-1.61.61.30.81.3
Novelty place preference2.12.22.8-1.41.6-1.7-1.71.71.30.81.4
Time in novel zone, NPP test2.12.12.9-1.41.6-1.7-1.71.71.20.71.4
Total zone transitions, NPP test0.20.30.90.6-0.50.40.4-0.4-0.9-0.2-0.8
Total locomotion distance, NPP test0.10.10.70.3-0.20.20.1-0.1-0.50.0-0.8
Locomotion velocity, NPP test0.40.61.40.9-0.80.70.7-0.7-0.7-0.1-1.2
Intraocular pressure0.50.82.1-0.80.7-0.7-0.80.8-0.9-0.41.4
Delta distance traveled before/after self-admin0.20.20.8-0.50.4-0.5-0.50.50.90.20.1
Delta ambulatory time before/after self-admin0.10.10.20.2-0.50.40.4-0.40.1-0.2-0.1
Parametrial fat weight0.91.82.5-1.61.5-1.4-1.41.40.70.81.6
Pavlov. Cond. lever latency1.72.23.0-1.41.5-1.7-1.71.71.41.30.9
Pavlov. Cond. magazine entry latency0.10.10.30.3-0.30.40.5-0.50.00.2-0.2
Pavlov. Cond. change in total contacts0.00.00.30.20.0-0.00.1-0.1-0.10.5-0.1
Pavlov. Cond. index score0.30.40.70.5-0.60.80.8-0.8-0.5-0.3-0.3
Pavlov. Cond. latency score0.20.30.60.4-0.50.70.8-0.8-0.4-0.3-0.3
Pavlov. Cond. lever contacts0.80.91.50.9-1.01.21.2-1.2-0.8-0.3-0.4
Pavlov. Cond. magazine entry number0.20.20.5-0.40.5-0.6-0.70.70.10.00.3
Pavlov. Cond. intertrial magazine entries0.81.02.90.6-0.80.80.8-0.8-1.3-1.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.60.90.8-0.80.91.0-1.0-0.7-0.4-0.4
Pavlov. Cond. response bias0.81.01.50.9-1.01.11.2-1.2-0.6-0.9-0.6
Pavlov. Cond. lever latency0.30.40.9-0.60.6-0.7-0.70.70.9-0.0-0.0
Pavlov. Cond. magazine entry latency0.50.60.80.8-0.80.80.8-0.8-0.90.4-0.5
Pavlov. Cond. change in total contacts0.20.20.80.10.1-0.2-0.10.1-0.70.70.9
Pavlov. Cond. index score0.30.40.70.7-0.60.70.7-0.7-0.80.2-0.1
Pavlov. Cond. latency score0.20.20.40.6-0.50.40.5-0.5-0.60.4-0.1
Pavlov. Cond. lever contacts0.10.20.40.3-0.30.30.3-0.3-0.60.40.6
Pavlov. Cond. magazine entry number0.30.40.8-0.90.6-0.5-0.50.50.7-0.70.3
Pavlov. Cond. intertrial magazine entries2.02.64.4-1.91.7-1.6-1.81.82.10.10.7
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.5-0.50.50.5-0.5-0.70.10.0
Pavlov. Cond. response bias0.50.61.40.9-0.80.80.8-0.8-1.20.50.1
Time in closed arm before self-admin1.51.75.1-0.91.0-1.1-1.11.11.62.20.5
Time in closed arm after self-admin2.52.63.9-1.11.5-1.6-1.61.61.92.01.3
Time in open arm before self-admin0.70.71.7-0.70.6-0.5-0.40.4-1.0-1.31.3
Time in open arm after self-admin0.91.02.40.6-0.80.90.9-0.9-1.5-0.8-1.2
Bone: periosteal estimation0.20.30.50.7-0.70.60.6-0.6-0.5-0.2-0.5
Bone: periosteal perimeter0.10.10.2-0.30.3-0.3-0.20.20.40.20.3
Bone: post-yield work0.10.10.6-0.20.1-0.1-0.10.1-0.00.8-0.6
Progressive ratio test 1 active lever presses1.11.25.90.9-0.3-0.1-0.10.1-0.32.4-1.5
Progressive ratio test 1 breakpoint1.31.36.81.0-0.3-0.1-0.10.1-0.32.6-1.6
Progressive ratio test 1 inactive lever presses0.91.02.01.4-0.90.50.5-0.5-0.51.4-1.4
Progressive ratio test 2 active lever presses0.50.63.40.7-0.40.00.0-0.0-0.31.8-0.6
Progressive ratio test 2 breakpoint0.50.52.60.8-0.50.20.2-0.2-0.41.6-0.7
Progressive ratio test 2 inactive lever presses0.30.41.00.9-0.60.30.3-0.3-0.40.7-1.0
Incentive Sensitization - Responses0.60.63.60.20.2-0.5-0.50.50.31.90.2
Incentive Sensitization - Breakpoint0.60.63.90.10.2-0.4-0.40.40.32.00.3
Sum of active levers in priming session hrs 5-60.60.61.00.5-0.80.91.0-1.0-0.4-0.8-0.3
Progressive ratio1.01.14.40.9-0.80.70.8-0.80.3-1.0-2.1
Food seeking constrained by brief footshock2.12.64.81.4-1.51.61.7-1.7-1.6-2.2-1.0
Seeking ratio, punishment vs. effort0.50.63.3-0.30.2-0.1-0.20.2-1.0-0.61.8
Retroperitoneal fat weight8.628.337.1-5.75.7-5.5-5.65.66.14.63.3
Reaction time number correct0.10.20.2-0.10.4-0.5-0.50.50.4-0.30.4
Reaction time mean minus median0.20.31.40.3-0.10.10.0-0.00.0-0.9-1.2
Reaction time mean minus median AUC0.50.61.0-0.91.0-0.8-1.01.00.5-0.30.2
Reaction time num false alarms0.60.83.8-0.20.2-0.4-0.20.2-1.50.11.9
Reaction time num false alarms AUC0.50.83.1-0.10.1-0.3-0.10.1-1.70.31.7
Reaction time trials correct on left0.10.20.2-0.10.4-0.5-0.50.50.4-0.30.4
Reaction time trials on left0.10.20.3-0.20.4-0.5-0.50.50.4-0.20.5
Reaction time mean0.60.81.5-0.91.2-1.1-1.21.20.50.10.3
Reaction time mean AUC0.91.21.9-1.21.4-1.3-1.41.40.70.20.4
Median of all reaction times1.01.32.2-1.21.5-1.4-1.41.40.60.20.6
Reaction time omissions1.21.62.7-1.61.5-1.4-1.51.50.20.01.0
Reaction time false alarm rate0.40.52.30.0-0.1-0.00.1-0.1-1.50.61.2
Reaction time premature initiation rate0.40.50.90.8-0.80.90.9-0.9-0.10.4-0.5
Reaction time premature initiations0.10.10.20.5-0.40.40.4-0.40.20.1-0.1
Std. dev. reaction times0.30.50.8-0.50.8-0.8-0.90.90.5-0.5-0.3
Reaction time trials completed0.10.20.3-0.20.4-0.5-0.50.50.4-0.20.5
Reaction time trials AUC0.00.10.10.10.1-0.3-0.20.20.2-0.30.2
Run reversals in cocaine runway, females0.10.10.60.0-0.10.00.0-0.00.60.80.3
Run reversals in cocaine runway, males0.30.30.90.4-0.40.50.4-0.4-0.00.90.6
Latency to leave start box in cocaine runway1.01.11.51.2-1.21.21.2-1.2-1.0-0.9-0.6
Latency to leave start box in cocaine runway, F2.02.23.01.4-1.51.61.6-1.6-1.7-1.4-0.6
Latency to leave start box in cocaine runway, M0.10.10.30.5-0.0-0.1-0.10.10.50.4-0.0
Std. dev. time between licks in bursts0.60.81.3-0.91.0-1.0-0.90.90.50.11.1
Total sessions with >9 infusions0.20.30.70.6-0.20.00.0-0.0-0.80.5-0.9
Short access day 1 total inactive lever presses0.80.93.70.8-0.50.40.4-0.4-0.11.9-1.4
Short access day 10 total inactive lever presses0.40.51.0-0.50.5-0.6-0.60.60.9-0.7-1.0
Short access day 1 total infusions0.91.02.21.0-0.90.70.7-0.7-1.11.5-1.2
Short access day 10 total infusions3.23.65.92.4-2.11.81.8-1.8-2.00.3-1.9
Short access total infusions1.41.62.31.5-1.31.11.1-1.1-1.40.9-1.5
Short access day 1 locomotion1.92.04.41.8-1.41.21.2-1.2-0.81.1-2.1
Short access day 10 total locomotion2.02.37.41.8-1.41.11.1-1.1-0.90.9-2.7
Short access total locomotion1.41.56.11.5-0.90.50.5-0.5-0.31.4-2.5
One hour access (0.3 mA shock)1.51.72.71.6-1.71.51.5-1.5-1.10.3-1.1
Compulsive drug intake0.20.20.6-0.50.3-0.2-0.20.20.8-0.50.6
One hour access (shock baseline)1.01.21.91.4-1.31.01.0-1.0-1.00.9-1.0
Social response proportion0.40.40.90.4-0.70.90.9-0.9-0.40.3-0.4
Social responses0.40.61.70.0-0.00.10.1-0.11.21.3-1.2
Social time0.50.72.70.7-0.70.70.8-0.80.2-0.2-1.6
Soleus weight2.05.97.92.6-2.82.72.7-2.7-2.8-0.3-1.8
Bone: stiffness0.30.51.1-0.90.7-0.7-0.60.60.40.41.0
Tibialis anterior weight2.37.910.63.3-3.02.92.9-2.9-3.20.2-2.9
Time to tail flick, vehicle, before self-admin4.64.77.9-2.82.5-2.3-2.22.21.50.72.4
Time to tail flick, vehicle, after self-admin1.21.34.6-1.11.1-0.9-1.01.02.20.1-0.7
Time to tail flick, test, before self-admin0.90.81.6-0.81.1-1.3-1.21.20.60.10.0
Time to tail flick, test, after self-admin1.61.63.6-1.51.1-0.9-0.90.91.91.9-0.1
Delta time to tail flick, vehicle, before/after SA0.80.82.01.0-0.91.00.9-0.90.0-0.6-1.4
Delta time to tail flick, test, before/after SA1.11.01.70.5-1.11.31.3-1.30.10.7-1.0
Tibia length1.64.58.4-1.81.9-1.9-2.02.02.92.91.0
Ambulatory time before self-admin1.91.95.4-0.91.2-1.4-1.31.31.22.30.9
Ambulatory time after self-admin0.91.02.2-0.80.7-0.7-0.80.81.41.50.9
Bone: tissue strength0.30.30.4-0.60.6-0.6-0.60.6-0.10.30.6
Total heroin consumption1.31.53.61.5-1.41.11.0-1.0-1.0-0.6-1.9
Bone: trabecular number5.68.711.13.0-3.33.33.2-3.2-2.6-2.6-2.1
Bone: trabecular spacing3.03.95.6-2.42.2-2.2-2.12.11.51.21.8
Bone: trabecular thickness1.61.92.91.6-1.71.71.6-1.6-1.0-0.2-0.9
Bone: trabecular tissue density0.00.10.20.4-0.10.00.1-0.10.2-0.2-0.5
Water consumed over 24 hours1.01.21.51.2-1.11.11.1-1.1-0.7-1.0-1.1
Number of responses in last shaping day1.41.41.9-1.31.3-1.4-1.41.40.81.00.8