Hub : Genes

Egfl8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Egfl8 0.06 0.03 4.3e-08 0.03 0.05 0.05 0.05 6.6e-05 2.2e-08 1.4e-07 1.7e-07
2 PL isoform ratio XM_063279354.1 0.03 0.02 3.6e-03 0.01 0.02 0.01 0.01 3.9e-02 6.3e-03 2.1e-02 1.8e-02
3 NAcc isoform ratio NM_001165880.2 0.01 0.01 8.0e-03 0.01 0.01 0.01 0.01 2.9e-03 3.2e-03 3.2e-02 2.7e-02
4 Adipose isoform ratio NM_001004070.3 0.04 0.02 1.7e-03 0.03 0.02 0.01 0.02 6.8e-04 4.2e-03 8.6e-03 1.2e-03
5 BLA isoform ratio NM_001165880.2 0.08 0.05 9.4e-04 0.03 0.04 0.04 0.03 1.5e-02 3.9e-03 5.4e-03 1.1e-02
6 PL gene expression Egfl8 0.07 0.04 1.2e-06 0.04 0.05 0.06 0.05 1.1e-05 1.5e-06 1.1e-06 2.7e-06
7 PL alternative TSS NM_001004070.3 0.02 0.02 9.7e-03 0.03 0.01 0.02 0.02 8.8e-04 3.9e-02 3.1e-03 3.2e-03
8 PL alternative TSS XM_063279354.1 0.02 0.02 8.6e-03 0.03 0.01 0.02 0.02 6.3e-04 2.3e-02 1.3e-03 1.5e-03
9 Adipose isoform ratio NM_001165880.2 0.06 0.03 1.2e-05 0.03 0.03 0.03 0.03 1.5e-04 3.7e-04 2.3e-04 9.2e-05
10 Adipose mRNA stability Egfl8 0.05 0.04 9.6e-03 0.03 0.01 0.01 0.02 2.5e-04 1.9e-02 6.6e-02 1.1e-03
11 Brain isoform ratio NM_001165880.2 0.06 0.04 5.6e-05 0.05 0.04 0.03 0.04 1.6e-05 1.1e-04 1.5e-03 3.3e-04
12 pVTA gene expression Egfl8 0.06 0.05 2.5e-03 0.02 0.02 0.01 0.02 7.9e-03 7.0e-03 8.8e-02 7.3e-03
13 IC isoform ratio NM_001165880.2 0.29 0.13 4.3e-09 0.17 0.22 0.21 0.23 1.8e-07 1.1e-09 2.4e-09 4.0e-10
14 Liver gene expression Egfl8 0.12 0.06 2.8e-10 0.08 0.1 0.09 0.09 1.6e-09 2.5e-11 6.0e-10 8.4e-10
15 IC gene expression Egfl8 0.1 0.06 1.6e-03 0.08 0.04 0.02 0.05 4.3e-04 9.7e-03 3.6e-02 3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.11.97.0-1.12.61.2-1.10.00.4-2.32.30.70.71.1-0.60.32.0-0.2
Area under the delay curve0.30.31.00.4-0.9-0.80.4-0.2-0.11.0-1.00.50.1-0.60.60.2-0.4-0.1
BMI with tail1.55.112.2-2.6-0.2-2.32.4-1.7-3.01.8-1.8-2.5-2.1-2.4-2.9-3.5-1.8-0.3
BMI without tail2.26.910.9-1.7-1.9-2.63.0-2.5-2.92.9-2.9-3.3-3.2-2.9-2.4-2.3-2.1-1.7
Body weight2.410.518.1-1.3-3.4-3.43.6-1.7-3.64.2-4.2-3.4-3.2-3.4-2.3-3.3-4.30.4
Weight adjusted by age1.21.85.10.2-2.3-1.31.2-0.4-1.31.7-1.7-1.0-1.8-1.1-0.8-0.6-2.00.3
Bone surface0.10.10.50.4-0.10.7-0.20.50.2-0.10.10.00.20.40.20.3-0.20.4
Bone volume0.10.10.5-0.50.70.3-0.1-0.1-0.2-0.60.6-0.3-0.10.3-0.5-0.00.4-0.1
Breakpoint value in progressive ratio session0.20.30.70.60.10.8-0.50.50.7-0.20.20.40.70.50.70.60.30.0
Number of licking bursts1.01.63.41.8-0.81.1-1.21.71.4-0.10.11.21.61.21.81.3-0.41.4
Context. condit. distance diff. score6.07.312.02.41.03.5-3.43.42.8-2.42.43.03.03.32.32.51.02.6
Locomotion velocity, session 11.61.74.01.50.11.5-1.51.01.7-1.11.11.40.91.61.42.01.00.1
Locomotion distance, session 10.91.13.2-0.41.81.3-1.00.30.8-1.51.51.10.91.1-0.00.51.5-0.0
Locomotion velocity, session 20.60.71.40.90.10.8-0.70.91.1-0.40.41.21.10.81.10.80.30.6
Locomotion distance, session 20.91.33.10.11.51.2-1.21.10.9-1.21.21.81.61.20.40.30.91.1
Locomotion velocity, session 30.30.42.1-0.60.2-0.50.6-1.0-0.30.2-0.2-0.5-0.4-0.6-0.4-0.20.4-1.5
Locomotion distance, session 31.51.73.40.11.71.4-1.30.51.2-1.81.81.41.41.20.60.91.7-0.4
Stereotopy head waving bouts, day 30.91.04.11.1-2.0-0.60.60.4-0.11.7-1.7-0.3-0.1-0.60.8-0.0-1.70.6
Stereotopy head waving duration, day 30.91.04.20.8-2.1-0.80.8-0.2-0.31.6-1.6-0.7-0.9-0.70.40.1-1.3-0.1
Locomotion velocity, session 73.94.38.30.12.92.2-2.21.71.6-2.92.92.62.42.20.60.82.11.3
Locomotion distance, session 74.65.812.10.33.12.5-2.61.52.2-3.53.52.72.62.61.01.72.90.4
Stereotopy head waving bouts, day 70.40.52.00.7-1.1-0.50.4-0.70.40.7-0.7-0.3-0.3-0.40.80.80.0-1.4
Stereotopy head waving duration, day 70.50.61.50.3-1.2-0.80.8-0.8-0.11.0-1.0-0.7-0.6-0.80.30.2-0.5-1.2
Locomotion velocity, session 83.54.29.33.0-1.32.1-2.02.82.4-0.30.32.22.21.92.82.1-0.62.0
Locomotion distance, session 85.68.113.61.91.83.7-3.53.52.7-2.72.73.53.53.42.01.91.23.1
Degree of sensitization distance0.60.61.61.1-0.40.7-0.81.20.7-0.20.20.80.80.81.00.7-0.41.3
Degree of sensitization stereotypy0.30.41.70.5-0.20.1-0.1-0.50.8-0.20.20.10.10.20.81.10.8-1.3
Conditioned locomotion0.50.62.20.1-1.0-0.50.50.4-0.71.1-1.1-0.5-0.2-0.5-0.3-0.8-1.50.8
Cocaine response after cond. corrected0.50.63.3-0.10.80.6-0.71.20.0-0.50.50.81.10.60.0-0.6-0.41.8
Cocaine response after cond. not corrected0.50.62.20.7-1.0-0.0-0.11.00.00.8-0.80.30.60.10.6-0.3-1.41.5
Cocaine response before conditioning2.52.910.91.1-3.3-1.61.6-0.9-0.52.6-2.6-1.5-1.4-1.60.60.1-1.9-0.9
Saline control response4.96.510.9-2.2-1.0-3.33.0-3.3-2.62.0-2.0-3.1-3.3-3.0-2.4-2.1-0.8-2.5
Bone: connectivity density0.81.34.3-0.72.11.3-1.10.60.3-1.91.90.70.71.1-0.50.01.20.7
Bone: cortical apparent density1.82.44.3-2.10.3-1.61.9-1.8-2.00.9-0.9-1.6-1.4-1.9-1.9-2.0-0.5-1.1
Bone: cortical area0.10.20.70.3-0.8-0.30.50.0-0.20.8-0.8-0.10.1-0.40.3-0.2-0.80.0
Bone: cortical porosity0.80.94.01.2-1.00.4-0.0-0.61.10.2-0.20.4-0.30.21.21.80.8-2.0
Bone: cortical porosity1.01.14.11.7-1.30.7-0.3-0.11.30.3-0.30.7-0.10.51.52.00.5-1.4
Bone: cortical thickness0.91.53.1-1.80.5-1.31.5-1.7-1.30.6-0.6-1.1-0.8-1.5-1.3-1.40.1-1.5
Bone: cortical thickness2.52.95.3-2.30.5-1.92.2-2.1-1.91.1-1.1-1.6-1.3-2.1-1.9-2.2-0.3-1.5
Bone: cortical tissue density1.72.33.8-1.90.2-1.51.9-1.7-1.91.0-1.0-1.5-1.4-1.8-1.8-1.9-0.6-1.1
Condit. Reinf. active minus inactive responses0.60.71.60.50.50.4-0.80.01.1-0.90.91.30.90.70.81.21.3-0.7
Condit. Reinf. active-inactive response ratio0.30.31.3-0.5-0.1-0.60.8-1.1-0.30.5-0.5-0.2-0.4-0.7-0.3-0.20.3-1.1
Condit. Reinf. active responses0.70.82.0-0.01.20.4-0.90.10.9-1.31.31.30.90.70.30.71.4-0.3
Condit. Reinf. inactive responses1.31.65.7-0.82.40.7-1.20.10.6-2.12.11.11.00.9-0.30.21.9-0.1
Incentive salience index mean2.22.76.01.40.71.6-1.91.71.9-1.41.42.52.21.71.71.61.11.0
Condit. Reinf. lever presses4.05.69.61.91.12.8-2.93.12.3-2.02.03.03.02.72.01.70.72.7
Condit. Reinf. active minus inactive responses0.40.62.10.4-1.5-0.50.6-0.5-0.31.1-1.1-0.8-0.9-0.70.10.1-0.7-0.5
Condit. Reinf. active-inactive response ratio0.70.83.81.1-2.0-0.40.30.1-0.01.3-1.3-0.6-0.7-0.40.50.5-1.10.1
Condit. Reinf. active responses0.10.20.50.1-0.6-0.20.3-0.5-0.10.3-0.3-0.6-0.6-0.4-0.10.2-0.0-0.7
Condit. Reinf. inactive responses0.30.40.9-1.00.6-0.40.7-0.9-0.6-0.10.1-0.6-0.3-0.6-0.7-0.70.3-0.8
Condit. Reinf. lever presses0.40.61.40.40.40.9-0.8-0.20.8-1.11.10.30.10.70.31.21.2-1.0
Condit. Reinf. lever reinforcers received0.10.10.50.3-0.60.00.1-0.40.20.2-0.2-0.4-0.3-0.20.20.50.1-0.7
Conditioned reinforcement - actives0.10.10.5-0.50.5-0.2-0.0-0.4-0.3-0.30.3-0.3-0.60.0-0.7-0.10.4-0.2
Conditioned reinforcement - inactives0.10.20.7-0.30.2-0.6-0.0-0.5-0.3-0.10.1-0.1-0.9-0.0-0.60.10.4-0.5
Conditioned locomotion0.10.10.20.20.10.1-0.40.20.1-0.30.30.4-0.20.4-0.10.40.20.1
Patch foraging indifference point 0 sec2.13.97.0-1.8-0.8-2.22.2-2.5-2.21.5-1.5-2.2-2.6-2.5-1.9-1.7-0.8-2.0
Patch foraging indifference point AUC0.20.31.00.5-0.9-0.30.5-0.30.30.9-0.9-0.1-0.1-0.30.70.4-0.3-1.0
Delay disc. indifference point, 0s delay0.40.41.50.9-0.50.2-0.50.90.40.2-0.20.90.80.40.80.4-0.41.2
Delay disc. indifference point, 16s delay0.30.41.2-0.60.1-1.00.7-1.0-0.50.5-0.50.0-0.3-0.7-0.4-0.20.3-1.1
Delay disc. indifference point, 2s delay0.70.73.01.4-1.7-0.5-0.10.40.51.0-1.00.6-0.0-0.01.10.9-0.80.7
Delay disc. indifference point, 24s delay0.50.61.90.2-1.1-1.10.9-0.9-0.31.0-1.00.1-0.5-0.80.20.3-0.1-1.4
Delay disc. indifference point, 4s delay1.01.13.30.4-1.7-1.31.0-0.5-0.51.8-1.8-0.6-0.5-1.10.3-0.1-1.10.2
Delay disc. indifference point, 8s delay0.10.10.60.3-0.3-0.50.2-0.10.10.4-0.40.80.4-0.30.60.2-0.0-0.2
Indifference point function ln k0.40.71.61.2-0.30.8-0.71.01.1-0.20.21.11.10.81.31.00.10.6
Indifference point function log k0.40.71.61.2-0.30.8-0.71.01.1-0.20.21.11.10.81.31.00.10.6
Patch foraging total patch changes 0 sec2.24.17.3-1.9-0.7-2.32.3-2.6-2.21.5-1.5-2.3-2.7-2.6-1.9-1.7-0.7-2.1
Patch foraging total patch changes 12 sec2.02.54.3-1.4-0.6-1.71.9-2.0-1.61.3-1.3-1.9-2.1-2.0-1.3-1.2-0.5-2.0
Patch foraging total patch changes 18 sec2.53.87.9-2.80.9-1.62.2-2.4-2.30.8-0.8-2.0-1.9-2.1-2.4-2.5-0.1-1.9
Patch foraging total patch changes 24 sec1.01.64.4-2.11.6-1.10.8-1.8-1.1-0.60.6-0.7-0.9-1.0-1.6-1.21.2-1.8
Patch foraging total patch changes 6 sec2.23.45.9-1.9-0.3-2.42.1-2.4-2.01.2-1.2-2.0-2.3-2.2-1.8-1.6-0.4-1.9
Patch foraging time to switch 0 sec0.61.34.6-1.81.0-0.50.7-0.4-1.6-0.20.2-1.0-0.6-0.8-2.0-2.2-0.51.0
Patch foraging water rate 0 sec0.20.30.80.0-0.8-0.90.6-0.3-0.50.9-0.9-0.2-0.5-0.5-0.1-0.3-0.7-0.4
Patch foraging water rate 12 sec0.10.30.9-0.90.9-0.10.3-0.7-0.3-0.40.4-0.3-0.0-0.2-0.5-0.40.7-0.7
Patch foraging water rate 18 sec0.30.41.2-0.7-0.3-1.10.7-0.8-0.80.4-0.4-0.6-0.5-0.9-0.6-0.7-0.4-0.5
Patch foraging water rate 24 sec0.20.30.8-0.80.2-0.50.6-0.8-0.60.1-0.1-0.9-0.4-0.6-0.7-0.5-0.0-0.6
Patch foraging water rate 6 sec0.20.30.6-0.70.3-0.70.7-0.6-0.50.4-0.4-0.3-0.1-0.5-0.5-0.7-0.1-0.5
Seeking ratio, delayed vs. immediate footshock1.41.83.6-0.3-1.3-1.11.9-1.4-0.81.7-1.7-1.7-0.8-1.80.0-0.6-0.9-1.7
Distance traveled before self-admin0.30.41.2-0.1-0.30.9-0.00.6-0.40.7-0.7-0.40.2-0.1-0.3-0.9-1.10.9
Distance traveled after self-admin1.41.75.5-0.0-1.7-0.81.3-0.5-0.92.3-2.3-1.5-1.0-1.3-0.3-0.9-1.7-0.0
Extensor digitorum longus weight0.10.51.51.0-0.80.7-0.61.10.40.3-0.30.30.30.70.50.4-0.81.2
Bone: elastic displacement0.30.41.8-0.50.5-0.20.3-1.0-0.0-0.40.4-0.0-0.6-0.3-0.30.31.0-1.3
Bone: elastic work0.10.20.4-0.3-0.4-0.30.6-0.6-0.40.3-0.3-0.2-0.6-0.6-0.3-0.3-0.2-0.5
Bone: endosteal estimation1.73.616.12.5-4.0-0.50.61.3-0.22.6-2.6-0.8-0.8-0.41.20.4-3.31.6
Bone: endosteal perimeter1.32.77.12.7-2.40.9-0.82.30.91.1-1.10.81.01.01.91.0-2.12.4
Epididymis fat weight5.318.142.1-6.52.5-3.94.2-4.9-5.41.0-1.0-4.5-4.3-4.1-6.3-5.9-0.2-2.4
Delta time in closed arm before/after self-admin0.30.30.8-0.0-0.6-0.10.20.2-0.50.5-0.5-0.5-0.6-0.1-0.5-0.5-0.90.9
Delta time in open arm before/after self-admin0.30.30.8-0.50.4-0.30.3-0.7-0.2-0.90.9-0.4-0.6-0.4-0.5-0.10.6-0.4
Diff in mean of infusions in LGA sessions1.21.53.40.31.71.4-1.41.51.2-1.01.01.51.81.40.90.40.90.8
Delay discount exponential model param0.30.41.1-0.51.10.9-0.50.30.0-1.01.0-0.4-0.10.6-0.6-0.20.40.2
Extinction: sum of active levers before priming0.70.81.61.1-0.20.8-0.91.30.90.1-0.11.11.10.91.00.8-0.21.2
Active lever presses in extinction session 60.20.20.7-0.50.80.2-0.3-0.3-0.0-0.60.60.4-0.40.3-0.6-0.00.8-0.6
Bone: final force2.03.25.8-1.5-0.9-2.22.1-1.3-2.21.8-1.8-1.9-1.6-2.1-1.7-2.4-1.8-0.1
Bone: final moment1.52.43.9-1.3-0.8-1.91.7-1.2-2.01.5-1.5-1.8-1.6-1.8-1.6-2.0-1.5-0.2
Food consumed during 24 hour testing period0.50.72.80.3-0.9-0.50.30.8-0.61.1-1.1-0.20.1-0.4-0.1-0.9-1.61.7
Glucose4.06.214.53.8-1.72.5-2.63.42.7-0.60.62.52.32.63.12.8-0.62.6
Heart weight1.21.96.10.6-2.5-1.81.1-0.8-0.72.0-2.0-1.0-1.6-1.2-0.00.1-1.5-0.7
Delay discount hyperbolic model param0.40.41.4-0.61.20.9-0.50.3-0.0-1.11.1-0.3-0.00.6-0.7-0.40.40.2
Intermittent access intake day 1-15 change0.10.10.3-0.1-0.2-0.20.4-0.4-0.10.5-0.5-0.5-0.1-0.40.2-0.1-0.2-0.4
Intermittent access intake escalation0.30.71.9-0.8-0.0-1.01.0-1.3-0.60.7-0.7-1.0-0.7-1.0-0.3-0.40.2-1.4
Intermittent access intake escalation 20.10.10.40.4-0.3-0.1-0.1-0.00.40.3-0.30.00.20.10.60.50.0-0.2
Intermitt. access day 1 inactive lever presses0.31.14.51.5-1.00.8-0.81.70.80.2-0.20.51.00.81.00.4-1.12.1
Intermitt. access day 15 inactive lever presses0.10.30.80.1-0.8-0.50.3-0.1-0.40.9-0.9-0.5-0.6-0.5-0.3-0.4-0.80.1
Intermitt. access escalation Index1.31.84.00.81.01.8-1.41.71.4-1.31.31.52.01.41.20.50.51.5
Intermittent access day 1 total infusions1.21.95.10.21.61.0-1.60.51.1-2.32.31.40.51.60.11.42.0-0.1
Intermittent access day 15 total infusions0.30.41.7-0.51.0-0.3-0.1-0.80.1-0.90.9-0.0-0.30.1-0.30.41.3-1.0
Intermittent access terminal intake (last 3 days)0.20.31.1-0.30.5-0.3-0.1-0.80.1-0.60.6-0.1-0.60.1-0.30.51.1-1.0
Intermittent access total infusions0.50.62.0-0.30.90.0-0.5-0.50.3-1.31.30.3-0.30.5-0.30.71.4-0.8
Intermittent access day 1 locomotion0.20.31.0-0.61.00.1-0.2-0.2-0.2-0.90.90.0-0.30.3-0.7-0.00.8-0.4
Intermittent access day 15 total locomotion0.40.71.2-0.6-0.5-0.91.0-0.8-1.11.0-1.0-1.0-0.9-1.0-0.7-0.8-0.7-0.5
Intermittent access total locomotion0.30.40.9-0.80.3-0.70.6-0.9-0.80.1-0.1-0.6-0.9-0.6-0.9-0.40.3-0.7
Intermittent access standard deviation1.42.95.9-1.4-0.8-2.41.9-1.8-2.01.5-1.5-2.0-2.1-1.9-1.7-1.6-1.0-1.0
Left kidney weight2.310.614.9-1.9-2.8-3.43.9-2.6-3.73.9-3.9-3.8-3.6-3.7-2.7-3.2-3.3-1.0
Right kidney weight2.19.613.7-1.9-2.6-3.13.7-2.2-3.73.6-3.6-3.6-3.4-3.5-2.7-3.4-3.5-0.3
Cocaine induced anxiety0.20.31.00.5-0.20.5-0.30.90.30.4-0.40.50.80.40.5-0.2-0.61.0
Post-drug Anxiety0.30.30.90.2-0.6-0.20.20.2-0.30.9-0.9-0.4-0.1-0.3-0.0-0.4-0.80.8
Baseline Anxiety0.10.20.3-0.1-0.5-0.50.5-0.4-0.40.5-0.5-0.5-0.5-0.5-0.2-0.2-0.30.1
Tail length1.45.423.02.1-4.8-1.51.7-0.2-0.73.8-3.8-1.6-1.7-1.51.10.7-3.2-0.1
Length with tail1.67.025.81.7-5.1-2.12.2-0.0-1.44.2-4.2-1.8-2.0-1.90.4-0.4-4.21.1
Length without tail1.75.617.50.0-3.2-1.92.00.3-2.43.2-3.2-1.8-1.6-1.9-1.1-2.4-4.22.4
Times rat made contact with spout0.81.04.6-1.21.4-0.50.3-1.50.0-0.80.80.00.0-0.4-0.3-0.01.7-2.1
Lifetime Intake0.40.41.4-0.20.7-0.1-0.3-0.50.2-1.21.20.3-0.50.4-0.40.61.2-0.6
Liver weight, left1.01.65.71.5-2.40.10.11.3-0.11.7-1.7-0.40.1-0.20.9-0.1-2.41.5
Liver weight, right1.22.16.42.2-2.50.3-0.31.70.51.5-1.50.40.30.31.40.7-2.22.2
Locomotor activity0.81.34.70.9-2.2-0.61.1-0.3-0.21.9-1.9-0.9-0.7-1.00.60.3-1.4-0.5
Locomotor testing distance0.30.62.30.7-1.5-0.10.60.1-0.21.3-1.3-0.6-0.4-0.60.40.1-1.20.1
Locomotor testing rearing0.40.82.40.3-1.4-0.50.50.1-0.71.2-1.2-1.0-0.9-0.7-0.2-0.6-1.60.9
Locomotion in novel chamber0.10.10.5-0.40.0-0.70.3-0.4-0.3-0.30.3-0.6-0.1-0.4-0.3-0.2-0.1-0.1
Locomotion in novel chamber post-restriction1.01.62.7-1.0-0.7-1.41.5-1.1-1.51.5-1.5-1.4-1.6-1.4-1.3-1.3-1.1-0.3
Fecal boli incidents, locomotor time 10.50.72.7-0.30.90.6-0.90.30.1-1.61.60.2-0.50.8-0.80.10.70.9
Change in fecal boli incidents, locomotor task1.21.23.41.2-1.8-0.30.40.80.11.7-1.70.00.6-0.41.20.1-1.71.2
Time >=10cm from walls, locomotor time 11.81.97.00.2-1.8-0.41.00.6-1.12.0-2.0-0.8-0.6-1.1-0.3-1.4-2.61.7
Bouts of movement, locomotor time 10.40.41.50.30.50.9-0.20.30.7-0.60.60.81.20.40.80.50.5-0.3
Total resting periods, locomotor time 10.30.41.20.40.40.9-0.30.50.7-0.50.50.71.10.50.80.60.4-0.2
Rest time, locomotor task time 10.20.20.70.8-0.40.6-0.50.50.70.2-0.20.0-0.10.60.40.70.00.6
Distance moved, locomotor task time 10.30.51.1-0.5-0.5-1.01.0-0.6-0.90.7-0.7-0.3-0.4-1.0-0.4-0.9-0.8-0.5
Vertical activity count, locomotor time 10.61.43.0-1.3-0.4-1.61.7-1.2-1.60.8-0.8-0.9-0.9-1.7-1.0-1.6-0.9-0.3
Time >=10cm from walls, locomotor time 21.01.54.50.6-2.1-0.90.90.3-0.91.9-1.9-0.3-0.6-1.00.1-0.5-2.11.3
Bouts of movement, locomotor time 20.10.20.50.5-0.7-0.30.2-0.30.40.4-0.4-0.10.2-0.30.70.60.0-0.1
Total resting periods, locomotor time 20.20.41.51.1-0.90.2-0.20.10.90.2-0.20.30.60.11.21.10.10.1
Rest time, locomotor task time 21.01.34.61.4-0.41.4-1.11.81.0-0.30.30.81.21.11.10.5-0.72.1
Distance moved, locomotor task time 21.11.32.8-1.4-0.0-1.71.3-1.3-1.60.6-0.6-0.5-1.3-1.3-1.4-1.3-0.4-1.0
Vertical activity count, locomotor time 20.71.02.2-1.0-0.4-1.51.2-1.0-1.40.6-0.6-0.6-1.1-1.3-1.1-1.0-0.6-0.4
Light reinforcement 10.41.03.4-1.0-0.1-1.01.1-0.2-1.40.8-0.8-0.8-0.2-1.1-0.9-1.9-1.40.6
Light reinforcement 20.30.51.8-0.2-0.4-0.70.40.5-0.80.3-0.3-0.20.1-0.3-0.4-1.0-1.31.3
Bone: marrow area1.83.816.72.3-4.1-0.70.81.2-0.42.7-2.7-1.0-1.0-0.61.10.2-3.41.6
Bone: maximum diameter1.12.05.42.3-1.41.0-1.12.01.30.3-0.31.31.51.22.01.4-1.01.6
Bone: maximum force0.91.62.7-0.9-0.9-1.41.5-0.8-1.71.4-1.4-1.3-1.2-1.4-1.2-1.6-1.40.0
Bone: maximum moment0.61.01.9-0.6-0.8-1.11.1-0.6-1.41.0-1.0-1.1-1.1-1.0-1.0-1.1-1.20.0
Mean time between licks in bursts1.33.26.42.5-0.82.2-2.02.32.1-0.70.71.61.61.92.22.2-0.11.7
Mean num. licks in bursts1.52.45.8-2.31.3-1.41.3-2.3-1.3-0.10.1-1.3-1.5-1.4-1.9-1.21.1-2.4
Cd content in liver0.50.62.1-1.21.4-0.1-0.00.0-0.8-0.70.7-0.0-0.20.3-1.4-1.00.30.5
Co content in liver1.61.83.4-1.5-0.2-1.61.4-1.2-1.81.1-1.1-1.5-1.3-1.4-1.8-1.8-0.9-0.2
Cu content in liver0.70.93.1-1.31.8-0.00.2-1.20.1-0.70.70.30.4-0.2-0.5-0.21.6-1.6
Fe content in liver0.91.12.5-1.40.3-1.01.0-1.2-1.40.6-0.6-1.1-1.3-1.0-1.6-1.4-0.2-0.3
K content in liver0.80.81.70.30.91.3-1.10.80.8-1.01.00.91.21.10.50.50.70.6
Mg content in liver2.72.75.01.80.02.2-1.82.21.8-1.01.01.72.21.81.91.30.01.7
Mn content in liver2.62.97.22.2-0.92.0-1.62.71.5-0.20.22.02.01.52.01.0-1.02.4
Na content in liver0.20.21.4-0.40.4-0.30.5-0.70.10.0-0.0-0.00.3-0.30.2-0.10.5-1.2
Rb content in liver0.40.41.4-0.00.80.6-0.80.80.2-0.90.90.20.40.8-0.10.00.21.2
Se content in liver2.83.39.02.8-1.21.4-1.72.12.4-0.20.22.02.31.53.02.2-0.10.9
Sr content in liver0.10.10.40.4-0.60.00.20.4-0.40.4-0.4-0.2-0.30.4-0.20.0-0.60.4
Zn content in liver0.20.30.70.6-0.10.7-0.60.80.4-0.20.20.40.30.70.30.3-0.20.9
Bone: minimum diameter0.91.74.52.0-2.10.6-0.41.80.51.1-1.10.60.70.51.40.5-1.92.0
Time in familiar zone, hab. session 11.81.75.7-1.52.30.3-0.1-1.30.1-1.71.7-0.1-0.20.2-0.90.22.4-1.9
Time in novel zone, hab. session 11.41.45.31.2-2.3-0.60.50.7-0.31.8-1.8-0.4-0.3-0.50.5-0.2-2.21.2
Total zone transitions, hab. session 10.40.51.00.40.61.0-0.80.70.8-0.80.80.71.00.80.60.60.60.6
Total locomotion distance, hab. session 10.50.71.10.20.91.1-0.90.70.7-1.01.00.70.90.90.30.40.70.9
Locomotion velocity, hab. session 10.30.40.70.20.60.8-0.70.50.6-0.80.80.50.70.60.40.40.50.6
Time in familiar zone, hab. session 20.60.71.5-1.20.6-0.41.0-1.2-0.80.2-0.2-1.1-0.4-0.9-0.8-0.90.3-1.0
Time in novel zone, hab. session 20.10.10.40.5-0.6-0.5-0.20.10.10.2-0.20.2-0.40.10.10.4-0.2-0.1
Total zone transitions, hab. session 20.10.20.7-0.40.60.40.10.4-0.2-0.10.10.00.50.0-0.2-0.7-0.20.9
Total locomotion distance, hab. session 20.70.92.4-0.31.51.1-0.80.90.4-1.11.10.81.30.80.0-0.30.51.5
Locomotion velocity, hab. session 21.11.42.80.01.61.6-1.21.30.8-1.41.41.21.71.20.40.10.71.6
Novel to familiar place preference ratio0.10.20.50.30.20.3-0.40.10.5-0.40.40.40.20.50.40.70.5-0.3
Novelty place preference0.10.10.60.5-0.10.2-0.30.00.5-0.20.20.30.10.40.50.80.4-0.4
Time in novel zone, NPP test0.10.10.60.5-0.30.0-0.2-0.10.40.0-0.00.2-0.10.30.50.80.3-0.4
Total zone transitions, NPP test1.42.03.90.31.72.0-1.61.31.2-1.81.81.41.41.70.40.81.21.1
Total locomotion distance, NPP test1.41.84.3-0.32.11.6-1.51.20.7-1.91.91.31.11.5-0.20.21.21.5
Locomotion velocity, NPP test1.92.76.1-0.22.52.0-1.91.51.0-2.32.31.61.61.8-0.10.31.41.7
Intraocular pressure0.40.51.8-1.21.3-0.20.2-0.7-0.6-0.80.8-0.3-0.3-0.1-1.0-0.40.9-0.7
Delta distance traveled before/after self-admin1.51.53.20.2-1.7-1.81.3-1.3-0.51.8-1.8-1.2-1.5-1.30.00.3-0.6-1.2
Delta ambulatory time before/after self-admin1.11.33.40.4-1.8-1.61.2-1.0-0.31.8-1.8-0.9-1.1-1.20.30.3-0.7-0.8
Parametrial fat weight1.94.410.2-2.60.3-2.42.3-1.5-2.91.5-1.5-2.1-1.8-2.1-2.7-3.2-1.5-0.3
Pavlov. Cond. lever latency6.37.912.2-3.1-0.4-3.33.4-3.0-3.52.2-2.2-3.2-2.9-3.3-3.1-3.4-1.5-1.5
Pavlov. Cond. magazine entry latency2.63.37.22.4-0.31.9-1.91.52.5-0.90.92.11.91.82.72.61.00.1
Pavlov. Cond. change in total contacts1.51.63.81.8-0.51.1-1.31.11.7-0.40.41.41.31.11.91.80.50.2
Pavlov. Cond. index score4.96.210.43.0-0.02.8-2.82.63.2-1.61.63.02.82.73.23.11.11.2
Pavlov. Cond. latency score5.26.611.03.1-0.02.9-2.92.73.3-1.61.63.02.92.83.33.21.11.2
Pavlov. Cond. lever contacts5.56.59.62.80.33.1-3.13.13.0-1.81.83.02.73.02.72.80.92.1
Pavlov. Cond. magazine entry number1.92.34.9-2.00.2-1.61.6-1.3-2.10.9-0.9-1.7-1.6-1.6-2.1-2.2-0.9-0.2
Pavlov. Cond. intertrial magazine entries1.11.44.2-2.01.6-1.10.5-1.2-1.3-0.70.7-0.8-0.8-0.6-2.0-1.30.7-0.8
Pavlov. Cond. lever-magazine prob. diff.4.96.110.12.90.12.8-2.82.63.2-1.71.73.02.82.73.13.11.21.2
Pavlov. Cond. response bias3.54.37.12.5-0.02.3-2.32.22.7-1.31.32.52.32.32.62.60.91.0
Pavlov. Cond. lever latency0.30.52.20.6-0.70.10.01.0-0.00.7-0.70.20.40.10.4-0.3-1.11.5
Pavlov. Cond. magazine entry latency0.40.41.10.80.00.7-0.90.60.7-0.70.70.60.40.80.61.00.40.4
Pavlov. Cond. change in total contacts0.20.32.0-0.1-0.1-0.00.2-0.80.1-0.10.1-0.4-0.6-0.1-0.10.60.7-1.4
Pavlov. Cond. index score0.20.20.80.30.10.4-0.4-0.20.5-0.60.60.1-0.10.40.20.90.7-0.8
Pavlov. Cond. latency score0.10.10.70.10.00.2-0.2-0.40.3-0.40.4-0.1-0.30.10.00.70.6-0.8
Pavlov. Cond. lever contacts0.30.41.8-0.60.5-0.10.1-0.9-0.1-0.60.6-0.3-0.4-0.2-0.40.20.9-1.3
Pavlov. Cond. magazine entry number0.10.10.2-0.1-0.2-0.20.4-0.2-0.20.5-0.5-0.2-0.0-0.4-0.0-0.4-0.3-0.2
Pavlov. Cond. intertrial magazine entries0.60.92.31.3-0.30.9-0.81.01.2-0.20.21.01.40.81.51.00.10.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.20.10.4-0.3-0.20.4-0.50.50.1-0.10.30.10.70.7-0.7
Pavlov. Cond. response bias0.30.41.00.10.50.4-0.6-0.10.6-1.01.00.40.20.40.30.81.0-0.7
Time in closed arm before self-admin0.10.20.50.6-0.7-0.4-0.00.30.20.7-0.70.10.00.10.40.4-0.4-0.2
Time in closed arm after self-admin0.10.10.20.1-0.2-0.1-0.10.2-0.10.5-0.5-0.3-0.20.2-0.2-0.0-0.30.3
Time in open arm before self-admin0.70.72.20.90.20.8-0.90.41.2-0.40.40.90.80.91.11.50.9-0.8
Time in open arm after self-admin0.20.20.90.3-0.00.2-0.3-0.30.5-0.80.80.1-0.30.20.20.90.7-0.6
Bone: periosteal estimation1.12.39.71.5-3.1-0.80.90.6-0.52.3-2.3-0.9-0.7-0.70.7-0.1-2.60.9
Bone: periosteal perimeter0.71.13.81.7-1.90.2-0.01.10.51.2-1.20.50.50.11.40.6-1.51.1
Bone: post-yield work0.71.03.01.4-1.10.9-1.01.70.40.3-0.30.30.50.90.80.5-1.21.7
Progressive ratio test 1 active lever presses0.20.20.60.10.30.2-0.50.20.2-0.80.80.5-0.20.6-0.10.60.60.0
Progressive ratio test 1 breakpoint0.10.20.50.20.20.2-0.50.20.3-0.70.70.5-0.20.6-0.10.60.50.1
Progressive ratio test 1 inactive lever presses0.30.41.2-1.11.0-0.40.3-0.4-0.8-0.40.4-0.5-0.5-0.2-1.1-0.90.30.1
Progressive ratio test 2 active lever presses0.40.41.3-0.21.10.3-0.5-0.00.4-1.11.10.50.30.6-0.00.41.1-0.0
Progressive ratio test 2 breakpoint0.40.51.5-0.31.20.2-0.5-0.10.4-1.21.20.40.20.6-0.10.41.2-0.2
Progressive ratio test 2 inactive lever presses0.50.91.90.90.30.7-1.41.11.0-1.01.01.10.41.40.51.20.60.8
Incentive Sensitization - Responses0.30.40.70.20.80.5-0.60.20.8-0.80.80.50.70.60.60.60.90.1
Incentive Sensitization - Breakpoint0.30.40.90.01.00.5-0.60.20.7-0.90.90.40.60.60.40.50.90.1
Sum of active levers in priming session hrs 5-60.40.41.50.9-0.31.0-0.80.40.80.0-0.00.60.10.70.61.20.4-0.2
Progressive ratio4.46.911.9-1.9-1.8-2.73.3-2.5-2.92.7-2.7-3.5-2.6-3.4-2.0-2.7-2.2-1.4
Food seeking constrained by brief footshock0.20.21.1-0.40.2-1.00.1-0.8-0.3-0.20.2-0.2-0.5-0.2-0.40.10.5-0.6
Seeking ratio, punishment vs. effort3.04.37.51.71.12.0-2.51.82.4-2.02.02.72.12.71.92.51.90.8
Retroperitoneal fat weight0.10.62.0-1.20.7-0.80.5-0.2-1.10.3-0.3-0.4-0.3-0.3-1.3-1.4-0.40.5
Reaction time number correct1.32.64.1-1.80.0-2.01.8-1.9-1.91.2-1.2-1.8-2.0-1.5-2.0-1.6-0.3-1.4
Reaction time mean minus median1.22.95.11.80.42.2-2.02.02.1-1.21.21.92.12.01.91.90.81.1
Reaction time mean minus median AUC1.63.97.11.80.92.7-2.42.12.3-1.71.72.32.12.51.72.21.31.1
Reaction time num false alarms0.30.41.71.1-0.70.3-0.50.70.70.1-0.10.50.70.21.30.7-0.40.5
Reaction time num false alarms AUC0.40.62.31.3-1.20.2-0.20.50.70.5-0.50.40.7-0.11.50.8-0.70.1
Reaction time trials correct on left1.32.64.1-1.80.0-2.01.8-1.9-1.91.2-1.2-1.8-2.0-1.5-2.0-1.6-0.3-1.4
Reaction time trials on left1.32.44.0-1.7-0.0-1.91.8-1.8-1.91.1-1.1-1.8-2.0-1.5-2.0-1.5-0.3-1.4
Reaction time mean2.33.77.31.90.32.3-2.22.72.0-1.31.32.32.32.31.81.60.32.4
Reaction time mean AUC2.23.56.61.80.42.2-2.12.61.9-1.31.32.32.22.21.81.60.42.2
Median of all reaction times1.72.45.61.50.21.7-1.82.31.4-1.11.11.91.81.81.31.10.02.4
Reaction time omissions1.42.04.01.50.21.7-1.62.01.4-1.01.01.51.71.71.41.30.11.7
Reaction time false alarm rate1.62.16.62.3-1.21.3-1.21.61.9-0.20.21.41.80.92.61.7-0.40.8
Reaction time premature initiation rate0.20.20.6-0.2-0.5-0.60.4-0.2-0.70.3-0.3-0.6-0.8-0.2-0.7-0.4-0.60.2
Reaction time premature initiations1.12.03.8-1.2-0.6-1.81.6-1.3-1.91.2-1.2-1.7-1.9-1.2-1.8-1.4-0.9-0.6
Std. dev. reaction times2.03.86.02.5-0.32.4-2.12.32.4-0.80.82.22.22.12.42.30.51.5
Reaction time trials completed1.32.44.0-1.7-0.0-1.91.8-1.8-1.91.1-1.1-1.8-2.0-1.5-2.0-1.5-0.3-1.4
Reaction time trials AUC1.22.43.9-1.70.1-1.81.7-1.7-1.91.1-1.1-1.7-1.9-1.5-2.0-1.6-0.4-1.2
Run reversals in cocaine runway, females0.40.41.2-1.00.7-0.20.4-0.7-0.7-0.40.4-0.6-0.8-0.3-1.1-0.70.4-0.3
Run reversals in cocaine runway, males0.70.71.41.0-0.01.2-1.01.01.0-0.50.50.80.81.10.91.10.30.7
Latency to leave start box in cocaine runway1.21.32.81.20.11.3-1.21.71.2-0.70.71.41.51.31.10.9-0.11.4
Latency to leave start box in cocaine runway, F1.01.11.90.90.51.4-1.21.41.1-0.90.91.31.31.30.90.80.31.0
Latency to leave start box in cocaine runway, M0.20.20.90.5-0.40.2-0.20.70.30.1-0.10.30.60.20.50.0-0.71.0
Std. dev. time between licks in bursts2.22.98.22.9-1.81.4-1.52.41.70.2-0.21.21.31.42.31.9-1.12.1
Total sessions with >9 infusions0.20.30.8-0.00.1-0.2-0.0-0.60.1-0.70.70.1-0.50.0-0.10.80.9-0.9
Short access day 1 total inactive lever presses0.60.82.01.3-0.30.4-1.21.11.0-0.60.61.10.31.20.61.40.30.8
Short access day 10 total inactive lever presses0.20.42.30.20.40.4-0.60.90.4-0.20.20.41.10.40.6-0.3-0.21.5
Short access day 1 total infusions0.50.61.60.60.30.3-0.80.30.7-1.21.21.00.00.90.31.31.0-0.1
Short access day 10 total infusions0.40.51.9-0.41.00.3-0.4-0.30.2-1.41.40.3-0.20.5-0.40.51.3-0.4
Short access total infusions0.40.51.90.10.60.2-0.6-0.10.4-1.41.40.7-0.30.7-0.10.91.2-0.3
Short access day 1 locomotion0.70.91.60.50.81.2-0.90.91.0-1.11.11.01.31.00.90.80.80.8
Short access day 10 total locomotion0.91.76.10.9-2.5-0.71.10.1-0.62.2-2.2-0.9-0.6-1.10.5-0.1-2.10.5
Short access total locomotion0.20.20.70.6-0.80.20.00.50.00.4-0.40.10.10.00.40.3-0.70.7
One hour access (0.3 mA shock)1.11.32.50.21.51.4-1.20.71.3-1.51.51.01.61.10.90.71.30.3
Compulsive drug intake2.12.56.71.50.02.3-1.52.51.4-0.10.11.32.61.21.90.3-0.92.4
One hour access (shock baseline)0.60.92.5-1.11.3-0.70.1-1.3-0.2-1.11.1-0.3-0.8-0.1-0.90.21.6-1.4
Social response proportion0.60.72.60.8-1.6-0.30.40.4-0.21.3-1.3-0.1-0.6-0.20.2-0.1-1.40.9
Social responses0.60.72.60.6-1.6-0.20.8-0.1-0.11.5-1.5-0.3-0.5-0.60.3-0.1-1.20.1
Social time1.82.57.32.0-0.71.8-1.22.21.6-0.20.21.42.11.32.11.0-0.82.7
Soleus weight1.64.611.83.4-3.01.6-1.33.21.31.2-1.21.51.31.12.61.2-2.73.1
Bone: stiffness0.71.22.8-1.2-0.0-1.31.3-0.8-1.51.0-1.0-1.1-0.7-1.2-1.2-1.7-0.9-0.0
Tibialis anterior weight0.20.82.1-1.40.6-0.80.9-1.2-1.00.3-0.3-0.9-0.7-1.0-1.2-1.20.0-0.8
Time to tail flick, vehicle, before self-admin0.40.41.5-0.60.80.80.20.3-0.10.6-0.60.31.2-0.20.3-1.0-0.30.8
Time to tail flick, vehicle, after self-admin0.40.61.30.90.00.4-0.80.80.9-0.50.51.11.00.81.10.90.30.4
Time to tail flick, test, before self-admin0.20.21.4-0.40.3-0.30.6-0.7-0.10.3-0.3-0.40.0-0.50.1-0.10.4-1.2
Time to tail flick, test, after self-admin1.31.43.30.31.51.0-1.30.31.3-1.61.60.90.91.30.71.31.8-0.5
Delta time to tail flick, vehicle, before/after SA1.21.13.50.40.80.1-1.10.10.8-1.91.91.10.11.10.21.41.6-0.5
Delta time to tail flick, test, before/after SA0.60.61.8-0.31.30.8-0.90.50.3-1.31.30.60.30.9-0.3-0.00.80.6
Tibia length1.13.011.41.5-3.4-1.00.80.8-0.92.4-2.4-1.4-1.0-1.00.4-0.5-3.11.7
Ambulatory time before self-admin0.10.11.0-0.00.21.0-0.30.40.00.1-0.1-0.00.20.2-0.1-0.4-0.30.3
Ambulatory time after self-admin1.01.13.90.2-1.5-0.60.9-0.5-0.52.0-2.0-1.1-1.0-0.9-0.1-0.4-1.3-0.1
Bone: tissue strength0.10.10.4-0.3-0.0-0.3-0.1-0.0-0.5-0.10.1-0.3-0.5-0.1-0.7-0.3-0.20.2
Total heroin consumption0.10.10.20.4-0.30.2-0.10.30.30.4-0.40.10.40.00.40.1-0.3-0.0
Bone: trabecular number1.62.610.0-1.33.21.3-1.4-0.00.5-2.72.70.80.81.3-0.80.22.4-0.3
Bone: trabecular spacing2.22.99.11.0-3.0-1.61.8-0.2-0.92.9-2.9-0.9-1.1-1.40.4-0.4-2.40.3
Bone: trabecular thickness1.01.35.6-1.32.40.5-0.9-0.1-0.0-1.91.90.30.40.7-0.9-0.31.50.0
Bone: trabecular tissue density0.30.41.30.7-0.9-0.30.2-0.50.30.6-0.6-0.4-0.50.00.61.10.2-1.1
Water consumed over 24 hours0.20.30.60.8-0.60.2-0.20.70.40.3-0.30.50.60.20.80.3-0.50.7
Number of responses in last shaping day1.11.24.62.1-2.20.2-0.30.91.00.5-0.50.60.20.41.51.6-1.00.4