Hub : Genes

Efna2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	NM_001168670.1	0.06	0.04	4.9e-05	0.04	0.03	0.03	0.03	2.1e-04	6.6e-04	1.1e-03	8.1e-04
2	Brain	alternative TSS	XM_039079982.1	0.06	0.04	8.2e-05	0.03	0.03	0.02	0.03	5.0e-04	1.3e-03	2.3e-03	1.5e-03
3	Brain	mRNA stability	Efna2	0.23	0.22	3.0e-10	0.08	0.08	0.08	0.08	1.0e-07	3.3e-08	6.0e-08	6.2e-08
4	Adipose	gene expression	Efna2	0.03	0.03	5.5e-04	0.01	0.01	0.01	0.01	1.4e-02	1.6e-02	1.1e-02	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.2	2.9	-0.9	0.9	1.7	0.8
Area under the delay curve	2.1	2.2	2.9	1.7	-1.7	-1.1	-1.4
BMI with tail	6.6	21.3	23.9	4.7	-4.7	-4.1	-4.9
BMI without tail	3.6	7.4	8.1	2.7	-2.7	-2.9	-2.7
Body weight	1.2	5.2	5.5	2.3	-2.3	-2.1	-2.4
Weight adjusted by age	1.4	1.6	2.3	1.3	-1.3	-1.5	-1.0
Bone surface	2.5	4.5	8.4	-1.8	1.8	2.9	1.7
Bone volume	2.4	4.0	7.6	-1.7	1.7	2.8	1.7
Breakpoint value in progressive ratio session	3.7	4.1	5.0	-2.2	2.2	1.4	2.2
Number of licking bursts	0.7	0.8	1.4	0.9	-0.9	-1.2	-0.5
Context. condit. distance diff. score	0.2	0.3	0.5	0.3	-0.3	-0.6	-0.7
Locomotion velocity, session 1	1.5	1.6	2.4	-1.2	1.2	1.5	1.1
Locomotion distance, session 1	2.4	3.1	4.1	-1.9	1.9	2.0	0.9
Locomotion velocity, session 2	8.5	10.0	11.5	-3.4	3.4	3.2	2.5
Locomotion distance, session 2	4.6	6.5	8.7	-2.5	2.5	2.9	2.1
Locomotion velocity, session 3	5.4	6.3	7.5	-2.7	2.7	1.9	2.6
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.0	-0.3	-0.2
Stereotopy head waving bouts, day 3	6.5	7.7	8.8	-3.0	3.0	2.5	2.6
Stereotopy head waving duration, day 3	6.4	7.7	8.6	-2.9	2.9	2.5	2.7
Locomotion velocity, session 7	0.6	0.7	1.0	-1.0	1.0	0.3	0.9
Locomotion distance, session 7	0.6	0.7	1.5	0.7	-0.7	-1.2	-0.6
Stereotopy head waving bouts, day 7	0.7	0.7	1.2	-0.9	0.9	1.1	0.4
Stereotopy head waving duration, day 7	1.2	1.5	2.2	-1.2	1.2	1.5	0.9
Locomotion velocity, session 8	2.9	3.5	4.1	-2.0	2.0	2.0	1.3
Locomotion distance, session 8	0.8	1.2	1.6	-1.3	1.3	1.1	0.5
Degree of sensitization distance	0.3	0.3	0.4	0.5	-0.5	-0.5	-0.6
Degree of sensitization stereotypy	0.6	0.7	1.2	0.9	-0.9	-0.3	-1.1
Conditioned locomotion	2.8	3.3	4.2	1.7	-1.7	-2.0	-1.7
Cocaine response after cond. corrected	9.5	10.7	11.6	3.4	-3.4	-3.3	-2.9
Cocaine response after cond. not corrected	10.0	11.0	11.7	3.4	-3.4	-3.4	-3.0
Cocaine response before conditioning	0.8	1.0	1.2	-1.1	1.1	0.8	0.9
Saline control response	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.3
Bone: connectivity density	0.2	0.3	1.0	-0.3	0.3	1.0	0.1
Bone: cortical apparent density	1.2	1.5	2.2	1.5	-1.5	-0.9	-1.0
Bone: cortical area	0.1	0.1	0.2	0.4	-0.4	0.0	-0.4
Bone: cortical porosity	1.1	1.2	1.3	-1.1	1.1	1.1	1.0
Bone: cortical porosity	0.7	0.8	1.2	-0.9	0.9	1.1	0.6
Bone: cortical thickness	0.6	0.9	1.1	1.0	-1.0	-0.6	-1.1
Bone: cortical thickness	0.5	0.6	0.9	0.8	-0.8	-1.0	-0.3
Bone: cortical tissue density	0.9	1.2	1.8	1.3	-1.3	-0.8	-0.8
Condit. Reinf. active minus inactive responses	4.4	5.0	5.9	-2.4	2.4	1.9	2.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.6	-1.0	1.0	0.7	1.3
Condit. Reinf. active responses	6.0	7.3	8.6	-2.9	2.9	2.6	2.4
Condit. Reinf. inactive responses	3.1	3.7	4.3	-2.1	2.1	2.0	1.4
Incentive salience index mean	4.0	4.9	5.9	-2.4	2.4	2.1	1.8
Condit. Reinf. lever presses	1.4	1.9	3.1	-1.4	1.4	1.8	0.7
Condit. Reinf. active minus inactive responses	0.7	0.8	1.9	-0.8	0.8	0.4	1.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.8	-0.8	-0.9	-0.2
Condit. Reinf. active responses	1.0	1.4	2.7	-1.0	1.0	0.7	1.6
Condit. Reinf. inactive responses	0.9	1.1	1.6	-1.0	1.0	0.8	1.3
Condit. Reinf. lever presses	1.0	1.4	2.2	-1.2	1.2	0.6	1.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.7	-0.7	0.7	0.3	1.3
Conditioned reinforcement - actives	2.3	2.3	2.7	-1.6	1.6	1.2	1.5
Conditioned reinforcement - inactives	0.7	0.8	1.0	0.8	-0.8	-1.0	-1.0
Conditioned locomotion	6.5	7.8	8.8	-3.0	3.0	2.2	2.9
Patch foraging indifference point 0 sec	0.0	0.1	0.1	0.3	-0.3	-0.1	-0.3
Patch foraging indifference point AUC	0.5	0.5	0.7	-0.8	0.8	0.5	0.9
Delay disc. indifference point, 0s delay	2.5	2.7	4.7	1.7	-1.7	-0.5	-2.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.6	-0.6	-0.2	-0.3
Delay disc. indifference point, 2s delay	3.5	3.9	5.3	2.1	-2.1	-1.3	-2.3
Delay disc. indifference point, 24s delay	1.3	1.3	1.7	1.3	-1.3	-1.0	-0.9
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	0.8	-0.8	-0.3	-0.8
Delay disc. indifference point, 8s delay	2.1	2.2	2.5	1.6	-1.6	-1.5	-1.2
Indifference point function ln k	0.3	0.5	0.6	0.8	-0.8	-0.7	-0.6
Indifference point function log k	0.3	0.5	0.6	0.8	-0.8	-0.7	-0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.3
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	0.8	-0.8	-1.1	-1.0
Patch foraging total patch changes 18 sec	0.9	1.2	1.4	-1.2	1.2	0.9	1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.2	0.2	0.3	0.3
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.5	0.5	0.6	0.7
Patch foraging time to switch 0 sec	0.2	0.2	0.7	-0.1	0.1	0.5	-0.8
Patch foraging water rate 0 sec	0.8	1.3	2.7	1.1	-1.1	-1.6	-0.5
Patch foraging water rate 12 sec	3.4	5.2	6.2	2.4	-2.4	-2.5	-1.8
Patch foraging water rate 18 sec	1.7	2.3	5.0	1.4	-1.4	-2.2	-0.7
Patch foraging water rate 24 sec	3.2	4.5	7.4	2.0	-2.0	-2.7	-1.5
Patch foraging water rate 6 sec	0.4	0.6	1.5	0.7	-0.7	-1.2	-0.0
Seeking ratio, delayed vs. immediate footshock	4.3	5.0	6.1	-2.2	2.2	2.1	2.5
Distance traveled before self-admin	0.2	0.2	0.3	0.6	-0.6	-0.2	-0.5
Distance traveled after self-admin	0.7	0.8	0.8	-0.9	0.9	0.9	0.9
Extensor digitorum longus weight	5.3	21.0	23.1	4.5	-4.5	-4.5	-4.8
Bone: elastic displacement	0.2	0.2	0.4	-0.2	0.2	0.5	0.6
Bone: elastic work	0.2	0.3	0.5	0.7	-0.7	-0.2	-0.2
Bone: endosteal estimation	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.4
Bone: endosteal perimeter	0.6	1.2	1.3	-1.1	1.1	1.1	1.0
Epididymis fat weight	0.1	0.3	0.5	-0.7	0.7	0.3	0.4
Delta time in closed arm before/after self-admin	3.7	3.6	5.4	1.8	-1.8	-2.3	-1.5
Delta time in open arm before/after self-admin	0.6	0.6	0.8	0.8	-0.8	-0.4	-0.9
Diff in mean of infusions in LGA sessions	1.9	2.1	2.4	-1.6	1.6	1.2	1.4
Delay discount exponential model param	2.1	2.2	2.8	-1.7	1.7	1.1	1.4
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.8	0.8	0.1	0.7
Active lever presses in extinction session 6	2.6	2.5	2.9	-1.6	1.6	1.4	1.7
Bone: final force	0.6	0.9	1.1	1.1	-1.1	-0.7	-1.0
Bone: final moment	0.5	0.7	0.9	1.0	-1.0	-0.6	-0.9
Food consumed during 24 hour testing period	1.1	1.4	1.9	1.4	-1.4	-1.0	-0.8
Glucose	1.8	2.7	3.4	1.8	-1.8	-1.3	-1.6
Heart weight	0.0	0.0	0.1	0.0	-0.0	-0.2	0.3
Delay discount hyperbolic model param	2.7	2.8	3.5	-1.9	1.9	1.3	1.6
Intermittent access intake day 1-15 change	5.0	5.0	6.1	-2.3	2.3	1.6	2.5
Intermittent access intake escalation	3.1	3.0	4.4	-1.9	1.9	0.9	2.1
Intermittent access intake escalation 2	3.9	3.9	5.4	-2.1	2.1	1.1	2.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.1	-0.1	-0.5	0.0
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.3	-0.6	0.6	0.3	0.6
Intermitt. access escalation Index	0.1	0.1	0.2	0.0	-0.0	0.5	0.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.2
Intermittent access day 15 total infusions	1.0	1.1	1.5	-1.1	1.1	0.6	1.2
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.0	-1.0	1.0	0.6	1.0
Intermittent access total infusions	0.1	0.1	0.1	-0.3	0.3	0.1	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.5	0.5	0.4	0.5
Intermittent access day 15 total locomotion	2.8	3.0	3.5	-1.9	1.9	1.4	1.8
Intermittent access total locomotion	0.9	1.0	1.1	-1.1	1.1	0.9	1.0
Intermittent access standard deviation	1.3	1.4	1.9	-1.3	1.3	0.7	1.4
Left kidney weight	0.1	0.2	0.4	-0.3	0.3	0.6	0.5
Right kidney weight	1.2	3.2	4.3	-1.8	1.8	1.6	2.1
Cocaine induced anxiety	1.4	1.7	2.3	-1.2	1.2	1.5	1.1
Post-drug Anxiety	1.4	1.6	2.3	-1.3	1.3	1.5	1.0
Baseline Anxiety	0.0	0.0	0.1	-0.0	0.0	-0.4	-0.0
Tail length	2.2	6.7	8.0	-2.8	2.8	1.8	2.8
Length with tail	2.0	7.1	8.1	-2.7	2.7	2.3	2.8
Length without tail	0.5	1.0	1.6	-1.0	1.0	1.3	0.8
Times rat made contact with spout	0.9	1.1	1.3	1.1	-1.1	-1.1	-0.7
Lifetime Intake	0.0	0.0	0.1	-0.2	0.2	0.2	0.2
Liver weight, left	2.4	3.8	5.0	1.9	-1.9	-1.8	-2.2
Liver weight, right	1.0	1.7	2.9	1.2	-1.2	-1.0	-1.7
Locomotor activity	4.6	7.3	7.8	-2.7	2.7	2.6	2.8
Locomotor testing distance	2.4	4.0	4.6	-2.0	2.0	1.9	2.1
Locomotor testing rearing	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.0
Locomotion in novel chamber	0.0	0.0	0.1	0.2	-0.2	-0.3	0.3
Locomotion in novel chamber post-restriction	0.5	0.6	0.9	-0.8	0.8	0.4	0.9
Fecal boli incidents, locomotor time 1	2.0	2.2	2.5	1.4	-1.4	-1.5	-1.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	-0.4	0.4	0.6	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.5	-0.5	0.1	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	0.3	0.1	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.2	-0.5	0.5	0.3	0.5
Rest time, locomotor task time 1	0.6	0.7	1.0	-1.0	1.0	0.7	0.6
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.6	-0.6	0.2	-0.3
Vertical activity count, locomotor time 1	1.0	1.0	1.5	1.2	-1.2	-0.9	-0.4
Time >=10cm from walls, locomotor time 2	2.3	2.4	2.7	1.6	-1.6	-1.6	-1.3
Bouts of movement, locomotor time 2	1.4	1.5	2.3	-1.1	1.1	1.5	1.0
Total resting periods, locomotor time 2	1.4	1.4	2.3	-1.1	1.1	1.5	1.0
Rest time, locomotor task time 2	0.9	1.1	1.3	-1.0	1.0	1.2	1.0
Distance moved, locomotor task time 2	0.9	1.1	1.3	0.9	-0.9	-1.1	-1.1
Vertical activity count, locomotor time 2	1.6	1.8	2.7	1.2	-1.2	-1.6	-1.3
Light reinforcement 1	7.0	12.7	13.9	-3.7	3.7	3.3	3.5
Light reinforcement 2	2.8	3.8	4.1	-2.0	2.0	1.8	1.9
Bone: marrow area	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.4
Bone: maximum diameter	1.5	2.7	3.1	-1.6	1.6	1.8	1.6
Bone: maximum force	0.8	1.3	1.6	1.2	-1.2	-0.9	-1.2
Bone: maximum moment	0.6	1.1	1.3	1.2	-1.2	-0.8	-1.0
Mean time between licks in bursts	3.0	4.2	5.2	-2.2	2.2	1.5	2.3
Mean num. licks in bursts	0.0	0.0	0.0	0.1	-0.1	0.2	-0.1
Cd content in liver	0.1	0.2	0.2	0.5	-0.5	-0.2	-0.3
Co content in liver	0.5	0.6	0.8	-0.9	0.9	0.4	0.7
Cu content in liver	0.1	0.1	0.4	-0.3	0.3	0.6	0.1
Fe content in liver	0.1	0.2	0.3	-0.6	0.6	-0.2	-0.0
K content in liver	0.9	0.8	1.2	-1.1	1.1	0.9	0.3
Mg content in liver	0.6	0.6	0.9	-0.9	0.9	0.9	0.3
Mn content in liver	4.3	4.9	5.8	-2.3	2.3	2.4	1.7
Na content in liver	0.2	0.2	0.4	-0.4	0.4	0.2	-0.6
Rb content in liver	0.1	0.1	0.3	-0.1	0.1	0.6	-0.2
Se content in liver	0.6	0.7	1.1	-1.1	1.1	0.6	0.5
Sr content in liver	0.3	0.2	0.6	0.4	-0.4	-0.8	-0.3
Zn content in liver	0.2	0.2	0.6	-0.3	0.3	-0.4	0.7
Bone: minimum diameter	0.1	0.1	0.2	-0.4	0.4	0.4	0.2
Time in familiar zone, hab. session 1	1.1	1.0	1.6	-1.0	1.0	0.6	1.3
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.6	-0.6	0.0	-0.6
Total zone transitions, hab. session 1	2.7	3.8	4.7	-2.0	2.0	2.2	1.6
Total locomotion distance, hab. session 1	4.2	5.9	7.2	-2.6	2.6	2.7	1.8
Locomotion velocity, hab. session 1	4.7	6.7	7.6	-2.8	2.8	2.7	2.0
Time in familiar zone, hab. session 2	2.8	2.9	4.8	-1.6	1.6	1.2	2.2
Time in novel zone, hab. session 2	2.7	2.7	3.3	1.8	-1.8	-0.9	-1.8
Total zone transitions, hab. session 2	0.8	1.0	2.8	-0.8	0.8	1.7	0.3
Total locomotion distance, hab. session 2	2.7	3.6	5.3	-1.9	1.9	2.3	1.5
Locomotion velocity, hab. session 2	3.2	4.3	6.8	-2.0	2.0	2.6	1.6
Novel to familiar place preference ratio	1.7	1.7	2.7	1.4	-1.4	-0.5	-1.6
Novelty place preference	0.9	0.9	1.4	1.0	-1.0	-0.2	-1.2
Time in novel zone, NPP test	1.2	1.2	1.8	1.2	-1.2	-0.4	-1.4
Total zone transitions, NPP test	0.6	0.9	1.8	-0.9	0.9	1.3	0.4
Total locomotion distance, NPP test	0.8	1.0	1.8	-1.1	1.1	1.3	0.3
Locomotion velocity, NPP test	1.0	1.5	2.4	-1.2	1.2	1.6	0.6
Intraocular pressure	0.8	1.2	1.9	1.1	-1.1	-1.4	-0.5
Delta distance traveled before/after self-admin	1.8	1.9	2.2	-1.5	1.5	1.1	1.4
Delta ambulatory time before/after self-admin	2.2	2.4	2.7	-1.6	1.6	1.3	1.5
Parametrial fat weight	0.1	0.3	0.5	-0.5	0.5	0.2	0.7
Pavlov. Cond. lever latency	0.8	1.0	1.4	1.2	-1.2	-1.0	-0.3
Pavlov. Cond. magazine entry latency	3.4	4.4	5.9	-2.4	2.4	1.5	1.8
Pavlov. Cond. change in total contacts	0.5	0.5	0.9	-1.0	1.0	0.4	0.3
Pavlov. Cond. index score	1.7	2.2	3.2	-1.8	1.8	1.3	0.9
Pavlov. Cond. latency score	2.2	2.8	3.9	-2.0	2.0	1.5	1.0
Pavlov. Cond. lever contacts	1.3	1.5	2.0	-1.4	1.4	1.3	0.6
Pavlov. Cond. magazine entry number	1.3	1.6	2.4	1.6	-1.6	-0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	-0.3	-0.5	0.0
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.7	3.8	-1.9	1.9	1.4	1.1
Pavlov. Cond. response bias	1.9	2.3	3.3	-1.8	1.8	1.1	1.2
Pavlov. Cond. lever latency	0.4	0.5	1.1	0.7	-0.7	-0.5	-1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	-0.7	0.7	0.5	0.7
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	-0.4	0.4	0.3	1.0
Pavlov. Cond. index score	0.4	0.5	1.0	-0.7	0.7	0.4	1.0
Pavlov. Cond. latency score	0.5	0.6	1.1	-0.7	0.7	0.6	1.0
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.5	0.5	0.2	0.9
Pavlov. Cond. magazine entry number	0.7	0.8	1.0	1.0	-1.0	-0.7	-1.0
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.2	1.0	-1.0	-1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.2	-0.8	0.8	0.6	1.1
Pavlov. Cond. response bias	0.7	1.0	2.0	-0.9	0.9	0.5	1.4
Time in closed arm before self-admin	0.1	0.1	0.3	-0.0	0.0	0.5	-0.4
Time in closed arm after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0
Time in open arm before self-admin	0.3	0.3	0.6	-0.5	0.5	0.3	0.8
Time in open arm after self-admin	0.9	0.9	1.1	1.1	-1.1	-0.8	-0.9
Bone: periosteal estimation	0.0	0.1	0.1	0.2	-0.2	0.2	-0.3
Bone: periosteal perimeter	0.4	0.7	1.0	-0.8	0.8	1.0	0.7
Bone: post-yield work	0.5	0.7	0.9	0.7	-0.7	-1.0	-0.9
Progressive ratio test 1 active lever presses	0.3	0.3	0.3	0.5	-0.5	-0.6	-0.4
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	0.6	-0.6	-0.6	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	0.2	0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.0	-0.0	-0.3	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.3	0.3	0.1	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	0.4	0.4	0.2
Incentive Sensitization - Responses	0.0	0.0	0.1	0.1	-0.1	-0.4	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.0	0.0	-0.2	0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0
Progressive ratio	0.2	0.2	0.5	0.2	-0.2	-0.6	-0.7
Food seeking constrained by brief footshock	0.7	0.8	1.2	-1.1	1.1	0.9	0.4
Seeking ratio, punishment vs. effort	0.5	0.6	0.9	-0.8	0.8	0.9	0.7
Retroperitoneal fat weight	0.3	1.0	1.3	0.9	-0.9	-0.9	-1.1
Reaction time number correct	2.0	2.9	3.7	1.7	-1.7	-1.9	-1.3
Reaction time mean minus median	0.3	0.4	0.7	-0.6	0.6	0.3	0.8
Reaction time mean minus median AUC	0.2	0.2	0.4	-0.4	0.4	0.6	0.3
Reaction time num false alarms	0.5	0.7	1.4	0.7	-0.7	-1.2	-0.6
Reaction time num false alarms AUC	0.8	1.1	2.1	0.9	-0.9	-1.5	-0.8
Reaction time trials correct on left	2.0	2.9	3.7	1.7	-1.7	-1.9	-1.3
Reaction time trials on left	1.9	2.8	3.5	1.7	-1.7	-1.9	-1.3
Reaction time mean	0.0	0.0	0.0	0.2	-0.2	0.2	0.2
Reaction time mean AUC	0.0	0.0	0.1	0.2	-0.2	0.2	0.1
Median of all reaction times	0.1	0.2	0.3	0.5	-0.5	-0.0	-0.3
Reaction time omissions	0.2	0.3	0.6	-0.3	0.3	0.8	0.7
Reaction time false alarm rate	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1
Reaction time premature initiation rate	0.3	0.4	0.9	-0.5	0.5	0.3	1.0
Reaction time premature initiations	0.2	0.2	0.5	0.4	-0.4	-0.7	0.3
Std. dev. reaction times	0.1	0.1	0.3	-0.3	0.3	0.3	0.5
Reaction time trials completed	1.9	2.8	3.5	1.7	-1.7	-1.9	-1.3
Reaction time trials AUC	2.2	3.1	4.2	1.8	-1.8	-2.0	-1.3
Run reversals in cocaine runway, females	0.5	0.5	0.5	-0.7	0.7	0.7	0.7
Run reversals in cocaine runway, males	1.9	1.9	1.9	-1.4	1.4	1.4	1.3
Latency to leave start box in cocaine runway	1.6	1.8	2.6	-1.2	1.2	1.6	1.3
Latency to leave start box in cocaine runway, F	0.5	0.6	1.6	-0.4	0.4	1.3	0.5
Latency to leave start box in cocaine runway, M	1.1	1.0	1.6	-1.1	1.1	0.3	1.2
Std. dev. time between licks in bursts	1.0	1.2	1.5	-1.0	1.0	1.1	1.2
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.0	0.3	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.4	0.4	0.4	0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1
Short access day 1 total infusions	0.7	0.7	1.1	-0.9	0.9	1.0	0.6
Short access day 10 total infusions	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1
Short access total infusions	0.0	0.0	0.0	-0.1	0.1	0.2	0.0
Short access day 1 locomotion	1.4	1.5	1.7	-1.2	1.2	1.3	1.3
Short access day 10 total locomotion	2.5	2.8	3.8	-1.8	1.8	1.2	2.0
Short access total locomotion	0.9	1.0	1.1	-1.0	1.0	0.9	1.0
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.3	-0.3	-0.3	-0.5
Compulsive drug intake	0.6	0.6	0.8	0.8	-0.8	-0.4	-0.9
One hour access (shock baseline)	0.0	0.0	0.1	0.0	-0.0	-0.3	0.0
Social response proportion	1.3	1.4	1.7	-1.2	1.2	1.3	1.1
Social responses	7.8	10.1	11.0	-3.3	3.3	2.9	3.3
Social time	0.3	0.4	0.7	0.7	-0.7	-0.4	-0.8
Soleus weight	8.5	24.9	27.2	5.2	-5.2	-4.3	-5.2
Bone: stiffness	1.7	2.7	3.8	1.6	-1.6	-1.4	-1.9
Tibialis anterior weight	1.0	3.4	4.4	1.8	-1.8	-1.7	-2.1
Time to tail flick, vehicle, before self-admin	1.3	1.3	1.8	-1.1	1.1	1.4	0.9
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.1	-0.1	-0.6	-0.0
Time to tail flick, test, before self-admin	0.8	0.8	1.3	-0.8	0.8	1.1	0.8
Time to tail flick, test, after self-admin	0.6	0.6	0.7	-0.8	0.8	0.8	0.7
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	2.7	1.1	-1.1	-1.6	-1.0
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	0.2	-0.3	0.0
Tibia length	0.6	1.8	2.4	-1.3	1.3	1.0	1.6
Ambulatory time before self-admin	0.2	0.3	0.3	0.6	-0.6	-0.2	-0.5
Ambulatory time after self-admin	0.4	0.4	0.5	-0.7	0.7	0.7	0.7
Bone: tissue strength	1.1	1.1	1.3	1.1	-1.1	-0.7	-1.1
Total heroin consumption	1.9	2.2	2.4	-1.5	1.5	1.3	1.6
Bone: trabecular number	1.8	2.9	3.7	-1.7	1.7	1.9	1.5
Bone: trabecular spacing	3.0	3.9	6.1	1.9	-1.9	-2.5	-1.5
Bone: trabecular thickness	2.0	2.3	5.3	-1.2	1.2	2.3	1.1
Bone: trabecular tissue density	1.9	2.6	3.0	1.6	-1.6	-1.7	-1.7
Water consumed over 24 hours	0.3	0.3	0.5	0.7	-0.7	-0.1	-0.5
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.4	0.3	0.3