Ebf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ebf2 0.03 0.02 5.2e-03 0.02 0.01 0 0.01 3.9e-03 6.8e-02 3.3e-01 5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density1.01.61.6-1.3
Area under the delay curve0.10.10.1-0.3
BMI with tail0.72.22.21.5
BMI without tail0.00.00.00.1
Body weight0.00.00.0-0.1
Weight adjusted by age0.00.00.00.1
Bone surface1.22.12.1-1.4
Bone volume1.42.32.3-1.5
Breakpoint value in progressive ratio session0.30.30.30.5
Number of licking bursts0.50.60.60.8
Context. condit. distance diff. score1.82.12.11.5
Locomotion velocity, session 10.00.00.0-0.2
Locomotion distance, session 11.82.42.4-1.5
Locomotion velocity, session 20.50.60.6-0.8
Locomotion distance, session 22.02.92.9-1.7
Locomotion velocity, session 31.51.71.71.3
Locomotion distance, session 30.80.80.80.9
Stereotopy head waving bouts, day 30.20.20.20.4
Stereotopy head waving duration, day 30.30.30.30.6
Locomotion velocity, session 70.20.30.30.5
Locomotion distance, session 70.10.10.1-0.3
Stereotopy head waving bouts, day 70.10.10.10.4
Stereotopy head waving duration, day 71.01.21.21.1
Locomotion velocity, session 81.11.31.31.1
Locomotion distance, session 80.00.00.0-0.1
Degree of sensitization distance1.41.41.4-1.2
Degree of sensitization stereotypy0.30.30.30.5
Conditioned locomotion0.81.01.01.0
Cocaine response after cond. corrected4.65.25.22.3
Cocaine response after cond. not corrected2.83.03.01.7
Cocaine response before conditioning3.03.63.6-1.9
Saline control response1.31.71.7-1.3
Bone: connectivity density0.81.21.2-1.1
Bone: cortical apparent density0.91.21.21.1
Bone: cortical area0.60.90.9-0.9
Bone: cortical porosity0.00.00.0-0.1
Bone: cortical porosity0.30.30.3-0.5
Bone: cortical thickness0.10.20.2-0.5
Bone: cortical thickness0.20.30.30.5
Bone: cortical tissue density1.11.41.41.2
Condit. Reinf. active minus inactive responses0.20.20.2-0.4
Condit. Reinf. active-inactive response ratio1.41.51.51.2
Condit. Reinf. active responses2.02.42.4-1.6
Condit. Reinf. inactive responses9.110.810.8-3.3
Incentive salience index mean0.50.70.7-0.8
Condit. Reinf. lever presses1.62.12.1-1.5
Condit. Reinf. active minus inactive responses0.30.40.4-0.6
Condit. Reinf. active-inactive response ratio0.50.50.50.7
Condit. Reinf. active responses1.01.41.4-1.2
Condit. Reinf. inactive responses2.83.53.5-1.9
Condit. Reinf. lever presses1.82.52.5-1.6
Condit. Reinf. lever reinforcers received1.01.41.4-1.2
Conditioned reinforcement - actives0.80.80.8-0.9
Conditioned reinforcement - inactives4.24.74.7-2.2
Conditioned locomotion0.40.50.5-0.7
Patch foraging indifference point 0 sec10.116.316.3-4.0
Patch foraging indifference point AUC3.13.63.61.9
Delay disc. indifference point, 0s delay1.82.02.0-1.4
Delay disc. indifference point, 16s delay0.00.00.0-0.2
Delay disc. indifference point, 2s delay0.20.20.2-0.4
Delay disc. indifference point, 24s delay0.10.10.10.3
Delay disc. indifference point, 4s delay0.90.90.91.0
Delay disc. indifference point, 8s delay0.10.10.1-0.3
Indifference point function ln k1.72.42.4-1.5
Indifference point function log k1.72.42.4-1.5
Patch foraging total patch changes 0 sec9.415.215.2-3.9
Patch foraging total patch changes 12 sec1.62.12.1-1.4
Patch foraging total patch changes 18 sec1.51.91.9-1.4
Patch foraging total patch changes 24 sec2.12.62.6-1.6
Patch foraging total patch changes 6 sec1.01.51.5-1.2
Patch foraging time to switch 0 sec0.00.00.0-0.2
Patch foraging water rate 0 sec0.00.10.1-0.2
Patch foraging water rate 12 sec0.10.10.1-0.4
Patch foraging water rate 18 sec0.70.90.90.9
Patch foraging water rate 24 sec0.10.10.10.4
Patch foraging water rate 6 sec0.00.00.00.0
Seeking ratio, delayed vs. immediate footshock3.13.63.6-1.9
Distance traveled before self-admin0.20.20.20.4
Distance traveled after self-admin1.21.41.41.2
Extensor digitorum longus weight6.927.227.25.2
Bone: elastic displacement2.02.32.3-1.5
Bone: elastic work4.65.95.9-2.4
Bone: endosteal estimation0.20.40.4-0.6
Bone: endosteal perimeter0.61.31.3-1.1
Epididymis fat weight1.12.62.6-1.6
Delta time in closed arm before/after self-admin0.60.60.6-0.8
Delta time in open arm before/after self-admin0.20.20.20.5
Diff in mean of infusions in LGA sessions0.10.10.10.3
Delay discount exponential model param0.00.00.00.0
Extinction: sum of active levers before priming1.31.31.3-1.2
Active lever presses in extinction session 60.00.00.00.1
Bone: final force0.10.10.1-0.3
Bone: final moment0.40.70.7-0.9
Food consumed during 24 hour testing period1.82.22.2-1.5
Glucose0.71.11.11.0
Heart weight0.81.11.1-1.1
Delay discount hyperbolic model param0.00.00.0-0.0
Intermittent access intake day 1-15 change0.30.30.3-0.6
Intermittent access intake escalation0.00.00.0-0.1
Intermittent access intake escalation 20.00.00.0-0.2
Intermitt. access day 1 inactive lever presses0.20.20.20.4
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0
Intermitt. access escalation Index0.50.40.40.7
Intermittent access day 1 total infusions0.00.00.0-0.1
Intermittent access day 15 total infusions0.00.00.00.1
Intermittent access terminal intake (last 3 days)0.30.30.30.6
Intermittent access total infusions0.00.00.00.2
Intermittent access day 1 locomotion1.41.51.5-1.2
Intermittent access day 15 total locomotion0.30.30.3-0.6
Intermittent access total locomotion0.80.90.9-0.9
Intermittent access standard deviation0.20.20.2-0.5
Left kidney weight0.20.60.6-0.7
Right kidney weight3.08.58.5-2.9
Cocaine induced anxiety0.91.11.1-1.0
Post-drug Anxiety1.92.12.1-1.5
Baseline Anxiety0.50.60.6-0.8
Tail length2.06.06.0-2.5
Length with tail0.72.62.6-1.6
Length without tail0.10.20.20.5
Times rat made contact with spout0.20.20.2-0.5
Lifetime Intake0.10.10.1-0.3
Liver weight, left0.91.41.41.2
Liver weight, right1.22.02.01.4
Locomotor activity1.42.22.2-1.5
Locomotor testing distance4.67.67.6-2.8
Locomotor testing rearing8.012.412.4-3.5
Locomotion in novel chamber0.00.00.00.1
Locomotion in novel chamber post-restriction0.60.80.80.9
Fecal boli incidents, locomotor time 10.00.00.0-0.1
Change in fecal boli incidents, locomotor task1.71.61.61.3
Time >=10cm from walls, locomotor time 11.51.51.5-1.2
Bouts of movement, locomotor time 13.63.93.92.0
Total resting periods, locomotor time 15.96.56.52.5
Rest time, locomotor task time 15.25.85.82.4
Distance moved, locomotor task time 12.52.72.7-1.7
Vertical activity count, locomotor time 12.22.32.3-1.5
Time >=10cm from walls, locomotor time 20.40.40.40.6
Bouts of movement, locomotor time 25.45.85.82.4
Total resting periods, locomotor time 27.37.87.82.8
Rest time, locomotor task time 24.65.35.32.3
Distance moved, locomotor task time 24.55.25.2-2.3
Vertical activity count, locomotor time 23.03.33.3-1.8
Light reinforcement 10.61.21.2-1.1
Light reinforcement 20.30.40.40.6
Bone: marrow area0.30.50.5-0.7
Bone: maximum diameter0.00.00.00.1
Bone: maximum force0.10.20.2-0.5
Bone: maximum moment0.71.21.2-1.1
Mean time between licks in bursts1.42.02.0-1.4
Mean num. licks in bursts0.80.90.9-1.0
Cd content in liver0.60.60.6-0.8
Co content in liver4.55.25.22.3
Cu content in liver1.11.41.41.2
Fe content in liver0.81.01.0-1.0
K content in liver0.00.00.0-0.1
Mg content in liver0.10.10.1-0.4
Mn content in liver1.61.91.9-1.4
Na content in liver1.41.51.5-1.2
Rb content in liver0.00.00.00.2
Se content in liver3.84.74.7-2.2
Sr content in liver0.20.20.2-0.5
Zn content in liver0.40.50.5-0.7
Bone: minimum diameter0.81.51.5-1.2
Time in familiar zone, hab. session 10.00.00.00.1
Time in novel zone, hab. session 12.01.91.91.4
Total zone transitions, hab. session 10.40.50.5-0.7
Total locomotion distance, hab. session 11.42.02.0-1.4
Locomotion velocity, hab. session 13.34.74.7-2.2
Time in familiar zone, hab. session 24.64.74.72.2
Time in novel zone, hab. session 22.22.22.2-1.5
Total zone transitions, hab. session 20.00.00.0-0.2
Total locomotion distance, hab. session 20.10.20.2-0.4
Locomotion velocity, hab. session 20.10.10.1-0.4
Novel to familiar place preference ratio1.11.11.1-1.1
Novelty place preference1.01.11.1-1.0
Time in novel zone, NPP test0.70.70.7-0.8
Total zone transitions, NPP test1.52.22.2-1.5
Total locomotion distance, NPP test5.67.77.7-2.8
Locomotion velocity, NPP test4.97.07.0-2.6
Intraocular pressure0.40.50.5-0.7
Delta distance traveled before/after self-admin2.83.03.01.7
Delta ambulatory time before/after self-admin1.71.91.91.4
Parametrial fat weight1.32.62.6-1.6
Pavlov. Cond. lever latency1.11.41.41.2
Pavlov. Cond. magazine entry latency0.40.50.5-0.7
Pavlov. Cond. change in total contacts0.30.30.3-0.5
Pavlov. Cond. index score0.60.70.7-0.8
Pavlov. Cond. latency score0.81.11.1-1.0
Pavlov. Cond. lever contacts1.11.31.3-1.1
Pavlov. Cond. magazine entry number0.10.10.10.3
Pavlov. Cond. intertrial magazine entries1.82.22.2-1.5
Pavlov. Cond. lever-magazine prob. diff.0.40.50.5-0.7
Pavlov. Cond. response bias0.10.10.1-0.4
Pavlov. Cond. lever latency0.20.30.30.5
Pavlov. Cond. magazine entry latency1.41.71.7-1.3
Pavlov. Cond. change in total contacts0.00.00.00.0
Pavlov. Cond. index score0.50.60.6-0.8
Pavlov. Cond. latency score0.91.11.1-1.0
Pavlov. Cond. lever contacts0.60.90.9-0.9
Pavlov. Cond. magazine entry number1.31.51.51.2
Pavlov. Cond. intertrial magazine entries3.44.54.5-2.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.6
Pavlov. Cond. response bias0.70.90.9-0.9
Time in closed arm before self-admin0.70.70.70.9
Time in closed arm after self-admin0.00.00.0-0.1
Time in open arm before self-admin0.20.20.2-0.4
Time in open arm after self-admin0.10.10.10.3
Bone: periosteal estimation0.40.90.9-1.0
Bone: periosteal perimeter0.61.01.0-1.0
Bone: post-yield work0.40.50.50.7
Progressive ratio test 1 active lever presses1.41.41.41.2
Progressive ratio test 1 breakpoint1.61.61.61.3
Progressive ratio test 1 inactive lever presses0.10.10.1-0.3
Progressive ratio test 2 active lever presses0.00.00.00.1
Progressive ratio test 2 breakpoint0.10.10.1-0.3
Progressive ratio test 2 inactive lever presses0.50.60.6-0.8
Incentive Sensitization - Responses1.61.71.7-1.3
Incentive Sensitization - Breakpoint2.22.22.2-1.5
Sum of active levers in priming session hrs 5-60.50.50.50.7
Progressive ratio0.00.00.00.1
Food seeking constrained by brief footshock6.47.97.92.8
Seeking ratio, punishment vs. effort1.72.12.11.4
Retroperitoneal fat weight0.00.00.00.0
Reaction time number correct1.11.61.61.3
Reaction time mean minus median0.00.00.0-0.0
Reaction time mean minus median AUC0.00.10.10.2
Reaction time num false alarms0.20.20.2-0.5
Reaction time num false alarms AUC0.20.30.3-0.5
Reaction time trials correct on left1.11.61.61.3
Reaction time trials on left1.01.41.41.2
Reaction time mean0.00.00.00.0
Reaction time mean AUC0.00.00.00.1
Median of all reaction times0.00.00.0-0.0
Reaction time omissions0.60.80.8-0.9
Reaction time false alarm rate0.60.80.8-0.9
Reaction time premature initiation rate0.91.21.21.1
Reaction time premature initiations2.23.13.11.8
Std. dev. reaction times0.00.00.00.2
Reaction time trials completed1.01.41.41.2
Reaction time trials AUC0.91.31.31.1
Run reversals in cocaine runway, females1.81.81.8-1.3
Run reversals in cocaine runway, males1.81.71.71.3
Latency to leave start box in cocaine runway2.42.62.61.6
Latency to leave start box in cocaine runway, F2.62.82.81.7
Latency to leave start box in cocaine runway, M0.10.10.1-0.3
Std. dev. time between licks in bursts6.07.27.2-2.7
Total sessions with >9 infusions0.00.00.00.2
Short access day 1 total inactive lever presses0.40.40.4-0.7
Short access day 10 total inactive lever presses0.10.10.10.2
Short access day 1 total infusions0.30.30.30.6
Short access day 10 total infusions0.30.30.3-0.6
Short access total infusions0.20.30.3-0.5
Short access day 1 locomotion0.20.20.2-0.5
Short access day 10 total locomotion1.92.12.1-1.5
Short access total locomotion1.92.02.0-1.4
One hour access (0.3 mA shock)0.10.20.2-0.4
Compulsive drug intake0.00.00.0-0.0
One hour access (shock baseline)0.00.00.00.1
Social response proportion2.32.52.51.6
Social responses0.71.01.0-1.0
Social time1.52.02.0-1.4
Soleus weight1.13.33.31.8
Bone: stiffness0.30.50.50.7
Tibialis anterior weight3.712.812.83.6
Time to tail flick, vehicle, before self-admin1.41.41.4-1.2
Time to tail flick, vehicle, after self-admin5.45.85.82.4
Time to tail flick, test, before self-admin1.71.71.7-1.3
Time to tail flick, test, after self-admin0.30.30.3-0.6
Delta time to tail flick, vehicle, before/after SA3.53.53.51.9
Delta time to tail flick, test, before/after SA1.41.31.31.1
Tibia length5.515.515.5-3.9
Ambulatory time before self-admin0.00.00.0-0.1
Ambulatory time after self-admin1.51.61.61.3
Bone: tissue strength0.70.60.6-0.8
Total heroin consumption0.10.10.10.3
Bone: trabecular number1.52.32.3-1.5
Bone: trabecular spacing1.21.61.61.3
Bone: trabecular thickness1.61.91.9-1.4
Bone: trabecular tissue density0.40.60.60.7
Water consumed over 24 hours0.00.00.00.2
Number of responses in last shaping day0.60.60.6-0.8