Hub : Genes

Ugt2b7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000070682	0.03	0.03	6.7e-03	0.01	-0	-0	0	3.3e-02	4.2e-01	9.8e-01	1.1e-01
2	Liver	gene expression	ENSRNOG00000070682	0.05	0.04	6.4e-04	0	0.01	0.02	0.02	3.4e-01	1.5e-02	5.9e-03	3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.3	0.9	1.8	1.3	-0.1
BMI without tail	0.4	0.9	1.7	-0.3	1.3
Body weight	0.0	0.2	0.3	0.2	0.6
Epididymis fat weight	0.2	0.6	1.1	-0.1	1.1
Glucose	0.7	1.1	1.1	-1.1	1.0
Heart weight	0.4	0.6	1.1	1.0	-0.2
Left kidney weight	0.0	0.0	0.0	-0.2	-0.1
Right kidney weight	0.5	1.4	1.9	-0.9	1.4
Tail length	0.0	0.0	0.0	-0.1	0.1
Length with tail	0.3	1.2	1.6	-1.3	0.9
Length without tail	0.3	0.7	1.2	-1.1	0.5
Liver weight, left	2.9	4.7	6.3	-1.8	2.5
Liver weight, right	2.8	4.6	4.8	-2.1	2.2
Parametrial fat weight	2.4	4.8	5.4	-2.3	2.1
Retroperitoneal fat weight	1.3	4.4	7.2	-1.3	2.7
Intraocular pressure	0.3	0.4	0.5	0.7	-0.5
Extensor digitorum longus weight	8.2	32.8	44.9	6.7	-4.5
Soleus weight	1.0	2.9	4.3	1.2	-2.1
Tibialis anterior weight	2.4	8.4	12.5	3.5	-2.1
Tibia length	0.3	0.9	1.1	-1.0	0.8
Number of licking bursts	0.1	0.1	0.1	0.3	-0.2
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.2	0.0
Times rat made contact with spout	0.3	0.4	0.5	-0.5	0.7
Mean time between licks in bursts	2.0	2.8	4.5	2.1	-1.0
Mean num. licks in bursts	0.6	0.7	1.0	-0.7	1.0
Std. dev. time between licks in bursts	1.5	1.8	2.0	1.4	-1.3
Water consumed over 24 hours	0.7	0.8	1.0	-1.0	0.7
Indifference point 0 sec	0.6	1.0	1.3	-1.1	0.9
Indifference point AUC	3.7	4.4	5.4	-1.8	2.3
Indifference point function ln k	1.2	1.6	2.1	1.1	-1.5
Indifference point function log k	1.2	1.6	2.1	1.1	-1.5
Delay discounting total patch changes 0 sec	0.7	1.1	1.4	-1.2	0.9
Delay discounting total patch changes 12 sec	1.8	2.4	3.9	-1.0	2.0
Delay discounting total patch changes 18 sec	0.6	0.7	1.1	-0.6	1.1
Delay discounting total patch changes 24 sec	0.6	0.8	1.0	-0.8	1.0
Delay discounting total patch changes 6 sec	1.6	2.4	2.5	-1.5	1.6
Delay discounting time to switch 0 sec	1.9	2.9	3.9	2.0	-1.4
Delay discounting water rate 0 sec	1.1	1.8	1.9	-1.4	1.3
Delay discounting water rate 12 sec	0.0	0.1	0.1	-0.1	-0.3
Delay discounting water rate 18 sec	0.5	0.6	1.2	-1.1	0.2
Delay discounting water rate 24 sec	0.1	0.2	0.2	-0.4	-0.4
Delay discounting water rate 6 sec	0.3	0.5	0.7	-0.8	0.5
Locomotor activity	0.1	0.2	0.4	-0.1	-0.6
Locomotor testing distance	0.7	1.1	2.0	0.5	-1.4
Locomotor testing rearing	0.9	1.4	2.3	0.7	-1.5
Light reinforcement 1	0.5	0.9	1.0	-1.0	0.9
Light reinforcement 2	0.0	0.0	0.1	0.2	-0.0
Reaction time number correct	0.3	0.4	0.5	0.7	-0.6
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1
Reaction time mean minus median AUC	0.3	0.4	0.9	-0.0	0.9
Reaction time num false alarms	1.1	1.6	2.2	-1.0	1.5
Reaction time num false alarms AUC	0.9	1.2	2.0	-0.7	1.4
Reaction time trials correct on left	0.3	0.4	0.5	0.7	-0.6
Reaction time trials on left	0.4	0.5	0.6	0.8	-0.7
Reaction time mean	0.0	0.1	0.1	0.2	-0.3
Reaction time mean AUC	0.0	0.0	0.0	-0.0	-0.1
Median of all reaction times	0.1	0.1	0.1	0.2	-0.4
Reaction time omissions	1.3	1.7	2.6	1.6	-0.9
Reaction time false alarm rate	1.2	1.7	2.5	-1.0	1.6
Reaction time premature initiation rate	0.3	0.4	0.6	-0.7	0.6
Reaction time premature initiations	0.2	0.3	0.3	-0.6	0.5
Std. dev. reaction times	0.0	0.0	0.0	0.1	-0.1
Reaction time trials completed	0.4	0.5	0.6	0.8	-0.7
Reaction time trials AUC	0.3	0.5	0.6	0.8	-0.5
Social response proportion	2.5	2.7	3.8	-1.3	2.0
Social responses	0.6	0.7	1.2	-0.5	1.1
Social time	0.9	1.2	1.3	-1.1	1.1
Conditioned locomotion	1.0	1.2	1.6	1.3	-0.8
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.7	0.5
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.5	0.0
Cocaine response before conditioning	0.4	0.5	0.9	0.3	-1.0
Saline control response	0.2	0.3	0.5	-0.7	0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.6	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	-0.5	0.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.6	0.1
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	-0.3
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.3	-0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.4	-0.2
Pavlov. Cond. lever latency	0.9	1.3	2.0	-0.7	1.4
Pavlov. Cond. magazine entry latency	2.0	2.3	3.0	1.3	-1.7
Pavlov. Cond. change in total contacts	2.0	2.8	3.5	1.5	-1.9
Pavlov. Cond. index score	2.7	3.5	4.9	1.4	-2.2
Pavlov. Cond. latency score	3.6	4.6	6.1	1.8	-2.5
Pavlov. Cond. lever contacts	1.1	1.5	2.4	0.7	-1.6
Pavlov. Cond. magazine entry number	3.6	4.4	5.9	-1.7	2.4
Pavlov. Cond. intertrial magazine entries	3.6	4.7	4.7	-2.2	2.2
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.2	4.5	1.4	-2.1
Pavlov. Cond. response bias	2.2	3.1	4.5	1.3	-2.1
Conditioned reinforcement - actives	1.0	1.0	1.2	0.8	-1.1
Conditioned reinforcement - inactives	0.4	0.4	0.8	-0.9	-0.3
Conditioned locomotion	0.2	0.3	0.5	0.2	-0.7
Intermittent access intake day 1-15 change	3.5	3.5	3.8	1.8	-1.9
Intermittent access intake escalation	2.3	2.3	2.8	1.3	-1.7
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	-0.4
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.1	-1.0	0.3
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	-0.9	0.8
Intermitt. access escalation Index	1.3	1.1	1.3	1.2	-1.0
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.2	-0.1
Intermittent access day 15 total infusions	0.6	0.7	1.0	0.6	-1.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.2	-0.5
Intermittent access total infusions	0.2	0.2	0.4	0.2	-0.6
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	-0.2
Intermittent access day 15 total locomotion	0.2	0.2	0.4	0.3	-0.6
Intermittent access total locomotion	0.1	0.1	0.2	0.3	-0.4
Intermittent access standard deviation	0.2	0.2	0.4	-0.0	-0.6
Cocaine induced anxiety	0.0	0.0	0.1	0.1	0.2
Post-drug Anxiety	0.6	0.7	1.1	-0.5	1.1
Baseline Anxiety	0.2	0.2	0.5	-0.0	-0.7
Lifetime Intake	0.3	0.4	0.6	0.3	-0.8
Incentive Sensitization - Responses	0.0	0.0	0.0	0.2	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.2	-0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.3	-0.4
Progressive ratio test 1 breakpoint	0.3	0.4	0.4	0.5	-0.7
Progressive ratio test 1 inactive lever presses	1.5	1.6	2.7	-1.7	0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	-0.7	0.0
Total sessions with >9 infusions	3.0	3.3	3.5	1.8	-1.9
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.4	-0.5
Short access day 10 total inactive lever presses	0.3	0.4	0.5	-0.7	-0.4
Short access day 1 total infusions	0.1	0.1	0.1	-0.3	-0.2
Short access day 10 total infusions	0.8	0.9	1.7	0.1	-1.3
Short access total infusions	0.6	0.7	1.1	0.6	-1.1
Short access day 1 locomotion	0.1	0.1	0.3	0.1	-0.5
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	0.1
Short access total locomotion	0.5	0.5	0.6	0.7	-0.8
Compulsive drug intake	0.5	0.5	0.9	-0.9	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.2	-0.6
One hour access (shock baseline)	0.1	0.1	0.1	0.4	-0.3
Number of responses in last shaping day	0.5	0.5	0.7	0.5	-0.9
Context. condit. distance diff. score	0.9	1.1	2.2	0.1	-1.5
Locomotion velocity, session 1	0.2	0.2	0.3	0.3	0.6
Locomotion distance, session 1	0.1	0.1	0.2	-0.4	-0.0
Locomotion velocity, session 2	0.1	0.1	0.2	-0.3	-0.4
Locomotion distance, session 2	0.0	0.0	0.1	-0.3	0.1
Locomotion velocity, session 3	0.4	0.5	0.8	-0.9	0.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	-0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.5	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.2	0.2
Locomotion velocity, session 7	2.6	2.9	3.0	-1.7	1.7
Locomotion distance, session 7	0.5	0.7	0.7	-0.9	0.8
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	0.5	-0.8
Stereotopy head waving duration, day 7	0.0	0.1	0.1	0.3	0.2
Locomotion velocity, session 8	0.6	0.7	1.2	-0.4	-1.1
Locomotion distance, session 8	0.6	0.9	1.6	-0.5	-1.3
Degree of sensitization distance	0.3	0.3	0.4	-0.5	0.6
Degree of sensitization stereotypy	0.3	0.3	0.5	0.3	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	0.8	-0.2
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.5	1.9	-1.4
Condit. Reinf. active responses	0.1	0.1	0.1	0.0	0.4
Condit. Reinf. inactive responses	1.3	1.5	1.8	-1.3	1.1
Incentive salience index mean	0.0	0.0	0.0	0.1	0.1
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	-0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.2	-0.6
Time in novel zone, hab. session 1	0.6	0.5	0.9	0.4	1.0
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.1	0.1
Total locomotion distance, hab. session 1	0.7	0.9	1.9	-1.4	0.1
Locomotion velocity, hab. session 1	0.4	0.6	1.2	-1.1	-0.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	-0.3
Time in novel zone, hab. session 2	0.7	0.7	1.4	-0.0	1.2
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.4	-0.5
Total locomotion distance, hab. session 2	0.3	0.3	0.7	-0.8	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	0.7	-0.8	-0.3
Novel to familiar place preference ratio	1.4	1.4	2.2	-0.8	1.5
Novelty place preference	1.3	1.4	2.4	-0.6	1.5
Time in novel zone, NPP test	2.0	2.1	3.4	-0.9	1.8
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	0.1
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.3	-0.8
Locomotion velocity, NPP test	0.4	0.6	1.1	0.1	-1.1
Pavlov. Cond. lever latency	0.8	1.0	1.1	0.9	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.2	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.4	0.4
Pavlov. Cond. index score	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. latency score	0.3	0.3	0.4	-0.6	0.6
Pavlov. Cond. lever contacts	0.9	1.0	1.1	-1.0	1.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.4	-0.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.8	0.6
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.8	0.6
Bone: apparent density	0.2	0.3	0.3	0.6	-0.6
Bone surface	0.5	1.0	1.5	0.6	-1.2
Bone volume	0.0	0.0	0.1	-0.1	-0.2
Bone: connectivity density	0.2	0.4	0.4	0.7	-0.5
Bone: cortical apparent density	2.4	3.1	5.1	-1.1	2.3
Bone: cortical area	0.3	0.5	0.5	-0.7	0.7
Bone: cortical porosity	2.7	2.9	3.0	1.7	-1.7
Bone: cortical porosity	3.0	3.2	3.8	1.9	-1.7
Bone: cortical thickness	0.2	0.3	0.5	0.7	-0.2
Bone: cortical thickness	0.3	0.4	0.6	0.4	-0.8
Bone: cortical tissue density	2.2	2.9	4.8	-1.0	2.2
Bone: elastic displacement	2.1	2.4	3.3	1.2	-1.8
Bone: elastic work	1.8	2.3	3.6	1.0	-1.9
Bone: endosteal estimation	0.8	1.7	3.1	-1.8	0.6
Bone: endosteal perimeter	0.2	0.4	0.8	-0.9	-0.0
Bone: final force	0.1	0.1	0.2	-0.1	0.4
Bone: final moment	0.0	0.1	0.1	-0.1	0.4
Bone: marrow area	0.7	1.5	2.8	-1.7	0.5
Bone: maximum diameter	0.2	0.4	0.7	-0.4	0.8
Bone: maximum force	0.2	0.3	0.5	-0.7	0.2
Bone: maximum moment	0.2	0.3	0.5	-0.7	0.3
Bone: minimum diameter	4.2	7.8	11.4	-3.4	2.1
Bone: periosteal estimation	0.5	1.1	1.7	-1.3	0.7
Bone: periosteal perimeter	0.2	0.3	0.5	-0.7	0.2
Bone: post-yield work	0.5	0.7	0.9	-1.0	0.7
Bone: stiffness	2.2	3.6	3.9	-1.8	2.0
Bone: tissue strength	0.9	0.9	1.0	-0.9	1.0
Bone: trabecular number	0.0	0.0	0.0	-0.0	0.2
Bone: trabecular spacing	0.7	0.9	1.8	-0.2	1.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.1	-0.4
Bone: trabecular tissue density	0.1	0.1	0.2	0.0	0.5
Breakpoint value in progressive ratio session	0.4	0.5	0.6	-0.8	0.6
Distance traveled before self-admin	0.3	0.3	0.4	-0.4	0.7
Distance traveled after self-admin	0.5	0.6	1.2	-1.1	0.1
Delta time in closed arm before/after self-admin	0.9	0.8	0.9	0.9	-0.9
Delta time in open arm before/after self-admin	2.2	2.1	2.6	-1.3	1.6
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.2	-0.3
Extinction: sum of active levers before priming	0.2	0.2	0.3	-0.6	-0.2
Active lever presses in extinction session 6	0.7	0.7	0.9	-0.9	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.1	-0.3	-0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.1	-0.5
Time in closed arm before self-admin	1.1	1.2	1.9	-0.8	1.4
Time in closed arm after self-admin	0.5	0.6	0.6	0.7	-0.8
Time in open arm before self-admin	2.9	3.0	4.0	1.4	-2.0
Time in open arm after self-admin	2.2	2.4	2.7	-1.5	1.6
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.1	-1.0	-0.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	-0.8	0.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.1	-0.6
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	0.2
Time to tail flick, test, after self-admin	2.3	2.4	2.5	-1.5	1.6
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	0.1
Delta time to tail flick, test, before/after SA	1.9	1.7	2.0	-1.2	1.4
Ambulatory time before self-admin	0.4	0.4	0.5	-0.7	0.6
Ambulatory time after self-admin	0.8	0.9	1.7	-1.3	0.3
Total heroin consumption	0.7	0.8	1.2	-1.1	0.7
Area under the delay curve	0.0	0.0	0.1	-0.2	0.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	0.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	0.2	0.2
Delay disc. indifference point, 2s delay	2.7	3.1	3.3	-1.8	1.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.4	-0.3
Delay disc. indifference point, 4s delay	1.0	1.1	1.1	-1.0	1.0
Delay disc. indifference point, 8s delay	0.5	0.5	0.6	0.8	-0.7
Delay discount exponential model param	0.1	0.1	0.2	0.4	-0.3
Delay discount hyperbolic model param	0.4	0.4	0.5	0.7	-0.6
Fecal boli incidents, locomotor time 1	2.2	2.4	2.6	1.5	-1.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.2	-0.6
Time >=10cm from walls, locomotor time 1	1.5	1.5	1.9	1.4	-1.0
Bouts of movement, locomotor time 1	0.4	0.5	0.6	0.8	-0.5
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.6	-0.4
Rest time, locomotor task time 1	0.4	0.4	0.7	-0.3	-0.9
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.2	0.5
Vertical activity count, locomotor time 1	2.9	3.0	5.1	-0.9	2.3
Time >=10cm from walls, locomotor time 2	1.4	1.5	2.2	0.9	-1.5
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.6	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	0.1
Rest time, locomotor task time 2	0.3	0.3	0.6	-0.2	-0.8
Distance moved, locomotor task time 2	0.3	0.4	0.8	0.9	-0.1
Vertical activity count, locomotor time 2	0.9	1.0	1.7	-0.5	1.3
Weight adjusted by age	1.2	1.4	1.9	1.4	-0.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	-1.0	-0.4
Locomotion in novel chamber	0.2	0.3	0.5	-0.0	0.7
Locomotion in novel chamber post-restriction	1.7	2.0	2.1	-1.4	1.4
Progressive ratio	0.9	1.0	1.2	1.1	-0.9
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.2	-0.6
Seeking ratio, punishment vs. effort	0.8	1.0	1.4	-1.2	0.8
Run reversals in cocaine runway, females	1.4	1.4	1.8	-1.3	1.0
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.8	-0.1
Latency to leave start box in cocaine runway	2.0	2.2	3.3	-1.8	1.1
Latency to leave start box in cocaine runway, F	4.3	4.7	5.4	-2.3	2.0
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	0.4	-1.0
Cd content in liver	0.6	0.7	1.0	1.0	-0.5
Co content in liver	0.3	0.3	0.5	-0.7	0.3
Cu content in liver	0.6	0.7	0.9	-0.9	0.7
Fe content in liver	0.1	0.1	0.3	0.2	0.5
K content in liver	3.8	3.8	4.7	-1.7	2.2
Mg content in liver	4.3	4.5	6.3	-1.6	2.5
Mn content in liver	0.0	0.0	0.0	0.2	-0.1
Na content in liver	2.6	2.7	3.8	-1.3	1.9
Rb content in liver	0.2	0.2	0.3	0.6	0.4
Se content in liver	0.4	0.5	0.6	-0.6	0.8
Sr content in liver	1.9	1.8	2.0	1.3	-1.4
Zn content in liver	0.7	0.7	0.8	-0.9	0.8