Hub : Genes

ENSRNOG00000069735

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000069735	0.11	0.07	1.7e-14	0.11	0.12	0.11	0.11	5.4e-12	2.2e-13	5.6e-12	1.4e-12
2	Adipose	isoform ratio	ENSRNOT00000110222	0.02	0.02	3.9e-03	0.02	0.02	0.02	0.01	3.5e-03	2.7e-03	5.6e-03	9.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.3	1.0	1.1	-1.0	1.0
BMI without tail	0.1	0.1	0.1	-0.4	0.3
Body weight	1.6	6.6	6.9	-2.6	2.5
Epididymis fat weight	15.3	35.7	36.1	-6.0	5.9
Glucose	0.6	0.8	0.8	-0.9	0.9
Heart weight	10.2	14.5	14.6	-3.8	3.8
Left kidney weight	0.0	0.0	0.0	0.2	-0.1
Right kidney weight	0.6	1.7	1.7	-1.3	1.3
Tail length	0.1	0.4	0.5	-0.7	0.6
Length with tail	1.3	4.9	5.2	-2.3	2.2
Length without tail	0.9	1.9	2.1	-1.4	1.3
Liver weight, left	2.2	3.6	3.6	-1.9	1.9
Liver weight, right	9.9	16.4	16.4	-4.1	4.0
Parametrial fat weight	5.3	10.3	10.6	-3.3	3.2
Retroperitoneal fat weight	21.9	72.4	73.1	-8.5	8.5
Intraocular pressure	2.8	4.0	4.1	-2.0	2.0
Extensor digitorum longus weight	5.1	20.5	20.6	4.5	-4.5
Soleus weight	6.0	17.5	17.5	4.2	-4.2
Tibialis anterior weight	4.4	15.3	15.5	3.9	-3.9
Tibia length	2.6	7.4	7.5	-2.7	2.7
Number of licking bursts	0.3	0.3	0.3	0.5	-0.6
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.3
Times rat made contact with spout	3.3	3.8	4.1	1.9	-2.0
Mean time between licks in bursts	2.8	3.9	4.0	-2.0	2.0
Mean num. licks in bursts	0.2	0.2	0.2	0.4	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	0.2
Water consumed over 24 hours	1.2	1.5	1.5	1.2	-1.2
Indifference point 0 sec	0.1	0.1	0.2	-0.4	0.2
Indifference point AUC	1.4	1.6	1.6	1.3	-1.3
Indifference point function ln k	0.0	0.0	0.0	-0.2	0.2
Indifference point function log k	0.0	0.0	0.0	-0.2	0.2
Delay discounting total patch changes 0 sec	0.0	0.1	0.1	-0.3	0.1
Delay discounting total patch changes 12 sec	0.5	0.7	0.8	-0.9	0.8
Delay discounting total patch changes 18 sec	0.0	0.0	0.0	0.1	-0.2
Delay discounting total patch changes 24 sec	1.3	1.6	1.7	-1.3	1.2
Delay discounting total patch changes 6 sec	0.0	0.0	0.0	0.0	-0.1
Delay discounting time to switch 0 sec	0.1	0.2	0.2	0.4	-0.5
Delay discounting water rate 0 sec	0.1	0.1	0.1	-0.3	0.3
Delay discounting water rate 12 sec	2.3	3.4	3.6	-1.8	1.9
Delay discounting water rate 18 sec	0.6	0.7	0.8	-0.8	0.9
Delay discounting water rate 24 sec	2.4	3.3	3.4	-1.8	1.9
Delay discounting water rate 6 sec	1.6	2.4	2.4	-1.5	1.6
Locomotor activity	0.1	0.1	0.1	0.3	-0.3
Locomotor testing distance	0.9	1.4	1.5	1.2	-1.2
Locomotor testing rearing	0.7	1.1	1.1	1.0	-1.0
Light reinforcement 1	4.5	8.2	8.4	2.8	-2.9
Light reinforcement 2	3.4	4.5	4.7	2.1	-2.2
Reaction time number correct	0.5	0.7	0.8	0.9	-0.8
Reaction time mean minus median	0.1	0.1	0.1	0.3	-0.3
Reaction time mean minus median AUC	0.0	0.0	0.0	0.1	-0.0
Reaction time num false alarms	0.4	0.6	0.6	0.7	-0.8
Reaction time num false alarms AUC	0.8	1.1	1.1	1.0	-1.1
Reaction time trials correct on left	0.5	0.7	0.8	0.9	-0.8
Reaction time trials on left	0.6	0.8	0.9	0.9	-0.8
Reaction time mean	0.3	0.4	0.5	-0.7	0.6
Reaction time mean AUC	0.2	0.3	0.3	-0.6	0.5
Median of all reaction times	0.4	0.5	0.5	-0.7	0.7
Reaction time omissions	0.2	0.2	0.2	0.4	-0.5
Reaction time false alarm rate	0.1	0.1	0.2	0.3	-0.4
Reaction time premature initiation rate	0.1	0.2	0.2	-0.5	0.4
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.0
Std. dev. reaction times	0.1	0.2	0.2	-0.4	0.4
Reaction time trials completed	0.6	0.8	0.9	0.9	-0.8
Reaction time trials AUC	0.8	1.1	1.2	1.1	-1.0
Social response proportion	0.3	0.3	0.3	-0.6	0.5
Social responses	0.0	0.0	0.0	-0.1	0.0
Social time	0.5	0.6	0.6	-0.8	0.7
Conditioned locomotion	2.6	3.1	3.1	1.8	-1.7
Cocaine response after cond. corrected	2.5	2.8	2.9	1.7	-1.7
Cocaine response after cond. not corrected	3.4	3.8	3.9	2.0	-1.9
Cocaine response before conditioning	0.5	0.6	0.6	0.8	-0.8
Saline control response	1.2	1.6	1.8	1.2	-1.3
Condit. Reinf. active minus inactive responses	2.9	3.6	4.0	2.0	-1.8
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.6	0.8	-0.7
Condit. Reinf. active responses	2.1	3.0	3.3	1.8	-1.6
Condit. Reinf. inactive responses	1.4	1.8	2.0	1.4	-1.3
Condit. Reinf. lever presses	1.3	1.8	1.9	1.4	-1.3
Condit. Reinf. lever reinforcers received	1.8	2.5	2.8	1.7	-1.5
Pavlov. Cond. lever latency	1.4	1.9	2.0	-1.4	1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.4
Pavlov. Cond. change in total contacts	0.4	0.5	0.6	0.8	-0.7
Pavlov. Cond. index score	0.5	0.7	0.7	0.9	-0.8
Pavlov. Cond. latency score	0.5	0.6	0.6	0.8	-0.7
Pavlov. Cond. lever contacts	0.6	0.8	0.8	0.9	-0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	2.8	3.6	3.6	-1.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	0.6	-0.5
Pavlov. Cond. response bias	1.2	1.7	1.8	1.3	-1.3
Conditioned reinforcement - actives	0.2	0.2	0.2	0.5	-0.5
Conditioned reinforcement - inactives	1.9	2.2	2.2	1.5	-1.5
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.3	0.4
Intermittent access intake escalation	0.4	0.4	0.5	-0.6	0.7
Intermittent access intake escalation 2	1.1	1.1	1.3	-1.0	1.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.0	-0.0
Intermitt. access day 15 inactive lever presses	4.4	4.8	4.8	2.2	-2.2
Intermitt. access escalation Index	0.3	0.3	0.3	-0.6	0.5
Intermittent access day 1 total infusions	5.1	5.8	6.0	2.4	-2.4
Intermittent access day 15 total infusions	1.5	1.6	1.7	1.3	-1.3
Intermittent access terminal intake (last 3 days)	1.4	1.6	1.6	1.3	-1.2
Intermittent access total infusions	1.7	1.9	1.9	1.4	-1.4
Intermittent access day 1 locomotion	2.7	2.8	2.8	1.7	-1.7
Intermittent access day 15 total locomotion	0.4	0.4	0.4	0.6	-0.6
Intermittent access total locomotion	0.2	0.2	0.2	0.5	-0.5
Intermittent access standard deviation	0.0	0.0	0.0	-0.2	0.2
Cocaine induced anxiety	0.1	0.1	0.1	0.3	-0.3
Post-drug Anxiety	0.4	0.5	0.5	-0.7	0.6
Baseline Anxiety	0.4	0.4	0.4	-0.7	0.7
Lifetime Intake	2.0	2.2	2.2	1.5	-1.5
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.2	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	-0.4	0.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.3	0.6	-0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.3	0.5	-0.5
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.0	1.0	-1.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.6	0.7	0.7	0.9	-0.8
Total sessions with >9 infusions	0.5	0.5	0.6	0.7	-0.7
Short access day 1 total inactive lever presses	3.2	3.6	3.7	1.9	-1.9
Short access day 10 total inactive lever presses	0.3	0.3	0.3	0.6	-0.6
Short access day 1 total infusions	1.7	1.8	1.8	1.4	-1.4
Short access day 10 total infusions	3.4	3.7	3.7	1.9	-1.9
Short access total infusions	1.2	1.3	1.4	1.1	-1.2
Short access day 1 locomotion	4.3	4.5	4.6	2.2	-2.1
Short access day 10 total locomotion	1.0	1.1	1.2	1.1	-1.0
Short access total locomotion	0.3	0.3	0.3	0.5	-0.5
Compulsive drug intake	0.3	0.3	0.3	-0.6	0.5
One hour access (0.3 mA shock)	1.2	1.4	1.4	1.2	-1.2
One hour access (shock baseline)	1.4	1.6	1.6	1.3	-1.3
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.0
Context. condit. distance diff. score	0.2	0.2	0.2	-0.5	0.5
Locomotion velocity, session 1	0.0	0.0	0.0	-0.2	0.2
Locomotion distance, session 1	2.2	2.8	2.8	1.7	-1.7
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	0.2
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.2
Locomotion velocity, session 3	0.5	0.6	0.7	0.7	-0.8
Locomotion distance, session 3	1.4	1.5	1.7	1.2	-1.3
Stereotopy head waving bouts, day 3	1.0	1.2	1.2	1.1	-1.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 7	0.8	0.8	1.0	0.9	-1.0
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	0.2
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	-0.1
Stereotopy head waving duration, day 7	0.8	0.9	1.0	0.9	-1.0
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	-0.2
Locomotion distance, session 8	0.1	0.1	0.1	0.4	-0.4
Degree of sensitization distance	1.8	1.8	1.9	-1.3	1.4
Degree of sensitization stereotypy	0.0	0.0	0.0	0.0	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.2	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.4	0.3
Condit. Reinf. active responses	0.5	0.6	0.6	0.8	-0.8
Condit. Reinf. inactive responses	1.4	1.7	1.9	1.4	-1.2
Incentive salience index mean	0.3	0.3	0.4	0.5	-0.6
Condit. Reinf. lever presses	1.6	2.1	2.3	1.4	-1.5
Time in familiar zone, hab. session 1	0.5	0.5	0.6	-0.8	0.7
Time in novel zone, hab. session 1	0.8	0.8	0.8	-0.8	0.9
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.3	-0.3
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, hab. session 1	0.6	0.9	1.0	1.0	-0.9
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	-0.2
Time in novel zone, hab. session 2	0.6	0.6	0.7	-0.7	0.8
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.4	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.4	-0.4
Locomotion velocity, hab. session 2	0.4	0.5	0.6	0.7	-0.7
Novel to familiar place preference ratio	0.8	0.9	1.0	-0.8	1.0
Novelty place preference	1.4	1.4	1.6	-1.1	1.3
Time in novel zone, NPP test	1.6	1.7	1.9	-1.2	1.4
Total zone transitions, NPP test	1.6	2.3	2.4	1.5	-1.5
Total locomotion distance, NPP test	1.4	2.0	2.1	1.4	-1.4
Locomotion velocity, NPP test	3.1	4.4	4.5	2.1	-2.1
Pavlov. Cond. lever latency	2.1	2.7	2.9	-1.6	1.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.2	-0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	-0.3
Pavlov. Cond. index score	0.8	1.0	1.1	1.0	-1.1
Pavlov. Cond. latency score	0.7	0.9	1.0	0.9	-1.0
Pavlov. Cond. lever contacts	1.4	1.6	1.8	1.2	-1.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	1.5	1.8	1.9	1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	2.4	1.4	-1.5
Pavlov. Cond. response bias	1.4	1.7	1.9	1.3	-1.4
Bone: apparent density	5.7	9.5	9.5	3.1	-3.1
Bone surface	2.1	3.7	3.7	1.9	-1.9
Bone volume	2.7	4.6	4.6	2.1	-2.1
Bone: connectivity density	5.5	8.6	8.7	3.0	-2.9
Bone: cortical apparent density	0.4	0.5	0.6	0.8	-0.7
Bone: cortical area	0.3	0.5	0.5	0.7	-0.7
Bone: cortical porosity	1.1	1.2	1.2	1.1	-1.1
Bone: cortical porosity	1.0	1.1	1.1	1.0	-1.0
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1
Bone: cortical thickness	1.2	1.4	1.5	1.2	-1.1
Bone: cortical tissue density	0.3	0.3	0.4	0.6	-0.5
Bone: elastic displacement	0.6	0.7	0.8	0.9	-0.8
Bone: elastic work	0.9	1.2	1.3	1.1	-1.1
Bone: endosteal estimation	0.2	0.4	0.4	0.6	-0.7
Bone: endosteal perimeter	0.1	0.2	0.2	0.4	-0.4
Bone: final force	0.1	0.2	0.2	0.4	-0.5
Bone: final moment	0.1	0.2	0.2	0.4	-0.5
Bone: marrow area	0.2	0.5	0.5	0.6	-0.7
Bone: maximum diameter	1.0	1.9	1.9	1.4	-1.4
Bone: maximum force	0.0	0.0	0.0	0.1	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	-0.1
Bone: minimum diameter	0.0	0.1	0.1	-0.3	0.1
Bone: periosteal estimation	0.5	0.9	1.0	1.0	-1.0
Bone: periosteal perimeter	0.1	0.2	0.2	0.5	-0.5
Bone: post-yield work	0.4	0.6	0.6	0.8	-0.8
Bone: stiffness	0.0	0.1	0.1	-0.2	0.2
Bone: tissue strength	0.3	0.3	0.3	-0.5	0.5
Bone: trabecular number	4.7	7.4	7.4	2.7	-2.7
Bone: trabecular spacing	1.8	2.3	2.5	-1.6	1.5
Bone: trabecular thickness	0.6	0.7	0.7	0.8	-0.9
Bone: trabecular tissue density	0.0	0.0	0.0	0.2	-0.2
Breakpoint value in progressive ratio session	0.7	0.8	0.8	0.9	-0.9
Distance traveled before self-admin	0.0	0.0	0.0	0.2	-0.1
Distance traveled after self-admin	0.2	0.2	0.2	-0.5	0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3
Delta time in open arm before/after self-admin	1.1	1.1	1.1	1.0	-1.0
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	0.5	-0.5
Extinction: sum of active levers before priming	1.0	1.0	1.0	1.0	-1.0
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	0.1
Delta distance traveled before/after self-admin	1.4	1.5	1.6	-1.2	1.2
Delta ambulatory time before/after self-admin	0.3	0.3	0.3	-0.5	0.5
Time in closed arm before self-admin	0.5	0.6	0.7	-0.7	0.8
Time in closed arm after self-admin	1.4	1.4	1.5	-1.2	1.2
Time in open arm before self-admin	0.1	0.1	0.1	0.3	-0.3
Time in open arm after self-admin	3.1	3.4	3.6	1.8	-1.9
Sum of active levers in priming session hrs 5-6	1.4	1.4	1.4	1.1	-1.2
Time to tail flick, vehicle, before self-admin	1.7	1.7	1.8	-1.3	1.3
Time to tail flick, vehicle, after self-admin	2.7	2.9	3.0	-1.7	1.7
Time to tail flick, test, before self-admin	0.6	0.6	0.6	0.8	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.2	0.1
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	0.4	-0.4
Ambulatory time before self-admin	0.2	0.2	0.2	0.5	-0.5
Ambulatory time after self-admin	0.1	0.1	0.1	-0.3	0.3
Total heroin consumption	2.6	3.2	3.2	1.8	-1.8
Area under the delay curve	1.4	1.5	1.5	1.2	-1.2
Delay disc. indifference point, 0s delay	0.5	0.5	0.6	-0.7	0.7
Delay disc. indifference point, 16s delay	1.9	2.0	2.1	1.4	-1.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 24s delay	5.9	5.7	5.8	2.4	-2.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 8s delay	1.5	1.5	1.5	1.2	-1.2
Delay discount exponential model param	2.2	2.4	2.4	-1.5	1.5
Delay discount hyperbolic model param	1.9	2.0	2.0	-1.4	1.4
Fecal boli incidents, locomotor time 1	0.7	0.7	0.7	0.9	-0.8
Change in fecal boli incidents, locomotor task	4.6	4.4	4.5	-2.1	2.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	0.1
Bouts of movement, locomotor time 1	4.3	4.7	4.7	2.2	-2.2
Total resting periods, locomotor time 1	4.0	4.5	4.5	2.1	-2.1
Rest time, locomotor task time 1	0.0	0.0	0.0	0.1	-0.2
Distance moved, locomotor task time 1	0.6	0.7	0.7	-0.8	0.8
Vertical activity count, locomotor time 1	0.4	0.5	0.5	-0.7	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.1	0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.2	-0.4	0.5
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	0.2
Rest time, locomotor task time 2	1.7	2.0	2.1	1.4	-1.4
Distance moved, locomotor task time 2	0.9	1.1	1.1	-1.1	1.0
Vertical activity count, locomotor time 2	1.4	1.6	1.6	-1.2	1.3
Weight adjusted by age	0.1	0.2	0.2	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.4	-0.6	0.6
Locomotion in novel chamber	1.4	1.7	1.7	-1.3	1.3
Locomotion in novel chamber post-restriction	1.8	2.1	2.2	-1.4	1.5
Progressive ratio	0.7	0.9	0.9	-0.9	0.9
Food seeking constrained by brief footshock	2.5	3.1	3.1	1.8	-1.7
Seeking ratio, punishment vs. effort	1.7	2.1	2.2	1.5	-1.4
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.0	0.1
Run reversals in cocaine runway, males	0.5	0.5	0.6	0.8	-0.7
Latency to leave start box in cocaine runway	0.4	0.5	0.5	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.7	0.8	0.8	0.8	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.2	-0.1
Cd content in liver	0.0	0.0	0.1	0.2	-0.1
Co content in liver	7.6	8.9	9.0	3.0	-3.0
Cu content in liver	0.3	0.4	0.5	0.6	-0.7
Fe content in liver	0.0	0.0	0.0	-0.2	0.2
K content in liver	0.2	0.2	0.3	-0.5	0.4
Mg content in liver	0.1	0.1	0.1	-0.4	0.1
Mn content in liver	0.2	0.2	0.2	0.5	-0.5
Na content in liver	0.2	0.2	0.3	0.4	-0.5
Rb content in liver	0.0	0.0	0.0	0.0	-0.2
Se content in liver	0.4	0.4	0.5	-0.7	0.6
Sr content in liver	0.2	0.2	0.2	-0.4	0.5
Zn content in liver	0.1	0.1	0.2	-0.4	0.3