Hub : Genes

ENSRNOG00000069560

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr19:18008033:18008164 0.06 0.04 3.3e-06 0.07 0.06 0.07 0.07 2.1e-07 1.2e-06 1.1e-06 5.1e-07
2 Liver gene expression ENSRNOG00000069560 0.17 0.08 0.0e+00 0.19 0.01 0.2 0.02 9.2e-21 2.0e-02 3.4e-21 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail2.06.67.2-2.72.4
BMI without tail0.10.20.2-0.40.5
Body weight0.93.83.8-2.01.9
Epididymis fat weight0.10.30.5-0.20.7
Glucose0.10.10.2-0.40.0
Heart weight2.23.13.4-1.71.8
Left kidney weight0.10.20.40.2-0.6
Right kidney weight0.10.30.4-0.60.5
Tail length1.54.64.92.0-2.2
Length with tail0.00.10.10.3-0.3
Length without tail1.94.24.3-2.02.1
Liver weight, left0.20.20.50.10.7
Liver weight, right0.00.10.10.20.3
Parametrial fat weight0.00.00.00.00.2
Retroperitoneal fat weight0.31.12.2-0.31.5
Intraocular pressure3.85.36.9-1.92.6
Extensor digitorum longus weight0.00.10.2-0.2-0.5
Soleus weight0.00.00.10.30.1
Tibialis anterior weight0.62.22.5-1.61.4
Tibia length0.61.73.0-1.70.6
Number of licking bursts0.30.40.40.6-0.7
Food consumed during 24 hour testing period7.48.910.33.2-2.7
Times rat made contact with spout0.10.10.20.4-0.2
Mean time between licks in bursts0.40.61.2-1.10.1
Mean num. licks in bursts0.00.10.1-0.10.3
Std. dev. time between licks in bursts0.50.61.00.3-1.0
Water consumed over 24 hours3.54.24.42.1-2.0
Indifference point 0 sec0.71.12.0-0.41.4
Indifference point AUC2.02.42.61.6-1.5
Indifference point function ln k1.41.92.5-1.21.6
Indifference point function log k1.41.92.5-1.21.6
Delay discounting total patch changes 0 sec0.91.52.6-0.61.6
Delay discounting total patch changes 12 sec1.41.93.21.8-0.8
Delay discounting total patch changes 18 sec2.63.44.82.2-1.4
Delay discounting total patch changes 24 sec0.91.22.01.4-0.6
Delay discounting total patch changes 6 sec0.30.40.90.9-0.2
Delay discounting time to switch 0 sec0.00.00.0-0.2-0.1
Delay discounting water rate 0 sec0.00.10.10.3-0.0
Delay discounting water rate 12 sec0.40.60.80.6-0.9
Delay discounting water rate 18 sec1.21.72.90.6-1.7
Delay discounting water rate 24 sec0.00.10.1-0.0-0.3
Delay discounting water rate 6 sec3.04.44.52.1-2.1
Locomotor activity0.81.31.6-1.31.0
Locomotor testing distance0.50.80.9-0.80.9
Locomotor testing rearing0.61.01.51.2-0.6
Light reinforcement 115.127.728.25.3-5.2
Light reinforcement 211.915.816.54.1-3.9
Reaction time number correct0.81.21.2-1.01.1
Reaction time mean minus median2.43.14.7-2.21.2
Reaction time mean minus median AUC1.72.23.1-1.71.2
Reaction time num false alarms3.64.97.0-1.72.6
Reaction time num false alarms AUC3.24.66.3-1.72.5
Reaction time trials correct on left0.81.21.2-1.01.1
Reaction time trials on left1.01.41.5-1.11.2
Reaction time mean2.83.95.3-2.31.6
Reaction time mean AUC3.04.05.4-2.31.6
Median of all reaction times2.12.93.8-2.01.4
Reaction time omissions2.73.64.2-2.01.7
Reaction time false alarm rate1.01.42.2-0.81.5
Reaction time premature initiation rate5.77.79.03.0-2.5
Reaction time premature initiations2.23.24.02.0-1.5
Std. dev. reaction times2.02.73.5-1.91.4
Reaction time trials completed1.01.41.5-1.11.2
Reaction time trials AUC0.91.31.5-1.11.2
Social response proportion0.10.10.1-0.3-0.0
Social responses0.00.10.10.20.2
Social time1.21.62.40.9-1.5
Conditioned locomotion0.20.20.30.5-0.3
Cocaine response after cond. corrected0.80.91.8-0.21.4
Cocaine response after cond. not corrected0.80.91.6-0.41.3
Cocaine response before conditioning0.70.81.40.4-1.2
Saline control response2.02.64.62.2-0.8
Condit. Reinf. active minus inactive responses0.00.10.1-0.30.1
Condit. Reinf. active-inactive response ratio0.20.20.4-0.60.3
Condit. Reinf. active responses0.00.10.1-0.30.2
Condit. Reinf. inactive responses0.30.30.5-0.40.7
Condit. Reinf. lever presses0.70.91.1-1.10.9
Condit. Reinf. lever reinforcers received0.30.40.6-0.70.5
Pavlov. Cond. lever latency0.20.30.5-0.20.7
Pavlov. Cond. magazine entry latency0.00.00.00.2-0.2
Pavlov. Cond. change in total contacts0.10.10.1-0.1-0.4
Pavlov. Cond. index score0.00.10.1-0.2-0.3
Pavlov. Cond. latency score0.00.10.1-0.1-0.3
Pavlov. Cond. lever contacts0.60.81.20.6-1.1
Pavlov. Cond. magazine entry number0.00.00.00.1-0.1
Pavlov. Cond. intertrial magazine entries0.50.70.90.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.1-0.3
Pavlov. Cond. response bias0.10.10.30.1-0.5
Conditioned reinforcement - actives1.21.21.5-0.91.2
Conditioned reinforcement - inactives0.91.01.6-0.71.3
Conditioned locomotion0.00.10.1-0.10.3
Intermittent access intake day 1-15 change4.14.14.52.1-1.9
Intermittent access intake escalation6.16.06.42.5-2.4
Intermittent access intake escalation 24.84.85.72.4-1.9
Intermitt. access day 1 inactive lever presses0.10.10.2-0.50.1
Intermitt. access day 15 inactive lever presses0.20.30.4-0.40.6
Intermitt. access escalation Index0.40.40.50.7-0.5
Intermittent access day 1 total infusions3.84.34.5-2.12.0
Intermittent access day 15 total infusions0.00.00.0-0.00.1
Intermittent access terminal intake (last 3 days)0.20.20.3-0.20.5
Intermittent access total infusions0.30.30.4-0.50.6
Intermittent access day 1 locomotion1.21.31.9-1.40.8
Intermittent access day 15 total locomotion0.70.81.2-1.10.6
Intermittent access total locomotion0.80.91.3-1.10.8
Intermittent access standard deviation0.40.40.40.6-0.6
Cocaine induced anxiety0.91.12.1-0.11.5
Post-drug Anxiety0.40.40.7-0.30.9
Baseline Anxiety0.30.30.6-0.2-0.8
Lifetime Intake0.20.30.4-0.30.6
Incentive Sensitization - Responses0.00.00.00.2-0.1
Incentive Sensitization - Breakpoint0.00.00.10.3-0.1
Progressive ratio test 1 active lever presses2.42.52.6-1.61.5
Progressive ratio test 1 breakpoint1.81.82.0-1.41.3
Progressive ratio test 1 inactive lever presses0.20.20.3-0.50.2
Progressive ratio test 2 active lever presses0.50.50.7-0.80.6
Progressive ratio test 2 breakpoint0.60.70.8-0.90.8
Progressive ratio test 2 inactive lever presses2.22.52.7-1.51.7
Total sessions with >9 infusions0.80.91.1-1.00.8
Short access day 1 total inactive lever presses0.20.20.40.6-0.3
Short access day 10 total inactive lever presses0.80.91.00.9-1.0
Short access day 1 total infusions2.02.12.3-1.41.5
Short access day 10 total infusions0.20.20.3-0.40.6
Short access total infusions0.10.10.2-0.20.5
Short access day 1 locomotion2.22.32.6-1.61.4
Short access day 10 total locomotion0.30.30.4-0.60.4
Short access total locomotion1.11.11.3-1.10.9
Compulsive drug intake1.21.21.51.2-0.9
One hour access (0.3 mA shock)0.10.10.20.40.4
One hour access (shock baseline)0.80.91.3-0.81.1
Number of responses in last shaping day4.64.75.1-2.12.3
Context. condit. distance diff. score2.12.64.5-0.82.1
Locomotion velocity, session 10.70.71.11.1-0.6
Locomotion distance, session 10.10.20.30.6-0.1
Locomotion velocity, session 20.30.40.80.9-0.0
Locomotion distance, session 20.10.20.30.00.6
Locomotion velocity, session 32.42.83.5-1.91.5
Locomotion distance, session 30.30.30.5-0.70.4
Stereotopy head waving bouts, day 30.70.91.0-1.00.9
Stereotopy head waving duration, day 31.31.51.7-1.21.3
Locomotion velocity, session 70.70.71.2-0.51.1
Locomotion distance, session 70.40.51.01.0-0.3
Stereotopy head waving bouts, day 71.11.21.9-1.40.8
Stereotopy head waving duration, day 70.20.20.4-0.6-0.2
Locomotion velocity, session 80.70.91.7-0.31.3
Locomotion distance, session 80.71.12.2-0.11.5
Degree of sensitization distance0.40.40.80.9-0.1
Degree of sensitization stereotypy1.21.32.0-1.40.8
Condit. Reinf. active minus inactive responses0.30.30.3-0.60.6
Condit. Reinf. active-inactive response ratio0.70.81.2-0.61.1
Condit. Reinf. active responses0.10.10.2-0.1-0.4
Condit. Reinf. inactive responses2.83.34.91.3-2.2
Incentive salience index mean0.40.50.80.5-0.9
Condit. Reinf. lever presses2.12.83.91.3-2.0
Time in familiar zone, hab. session 11.31.21.60.9-1.3
Time in novel zone, hab. session 11.01.01.0-1.01.0
Total zone transitions, hab. session 10.10.20.4-0.00.6
Total locomotion distance, hab. session 10.30.50.8-0.40.9
Locomotion velocity, hab. session 10.30.40.8-0.20.9
Time in familiar zone, hab. session 22.32.42.91.7-1.4
Time in novel zone, hab. session 23.63.63.7-1.91.9
Total zone transitions, hab. session 20.10.10.10.40.1
Total locomotion distance, hab. session 20.10.20.20.30.5
Locomotion velocity, hab. session 20.10.10.20.40.2
Novel to familiar place preference ratio1.61.71.8-1.31.3
Novelty place preference1.31.41.5-1.21.1
Time in novel zone, NPP test1.41.51.8-1.41.1
Total zone transitions, NPP test0.10.10.20.40.1
Total locomotion distance, NPP test0.10.10.2-0.10.4
Locomotion velocity, NPP test0.00.00.10.30.2
Pavlov. Cond. lever latency0.00.00.00.20.1
Pavlov. Cond. magazine entry latency0.10.10.1-0.40.1
Pavlov. Cond. change in total contacts0.60.70.90.7-0.9
Pavlov. Cond. index score0.10.10.2-0.50.2
Pavlov. Cond. latency score0.00.00.0-0.20.1
Pavlov. Cond. lever contacts0.10.10.2-0.50.1
Pavlov. Cond. magazine entry number0.10.20.30.60.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.70.4
Pavlov. Cond. response bias0.30.40.8-0.90.2
Bone: apparent density1.52.43.11.8-1.3
Bone surface0.40.70.90.9-0.7
Bone volume1.32.32.31.5-1.5
Bone: connectivity density1.52.43.41.8-1.2
Bone: cortical apparent density0.00.00.00.10.1
Bone: cortical area0.00.00.10.1-0.3
Bone: cortical porosity0.10.20.3-0.60.1
Bone: cortical porosity0.20.20.3-0.6-0.2
Bone: cortical thickness0.00.00.0-0.2-0.1
Bone: cortical thickness0.30.30.5-0.30.7
Bone: cortical tissue density0.00.00.00.10.1
Bone: elastic displacement0.00.00.0-0.00.1
Bone: elastic work0.00.00.0-0.10.2
Bone: endosteal estimation0.10.10.2-0.20.5
Bone: endosteal perimeter0.20.30.6-0.20.8
Bone: final force0.50.91.30.7-1.2
Bone: final moment0.30.40.70.4-0.8
Bone: marrow area0.10.20.3-0.30.6
Bone: maximum diameter0.40.80.9-1.00.8
Bone: maximum force0.00.00.00.2-0.2
Bone: maximum moment0.00.00.0-0.1-0.0
Bone: minimum diameter1.01.81.91.3-1.4
Bone: periosteal estimation0.00.00.00.10.0
Bone: periosteal perimeter0.20.30.5-0.30.7
Bone: post-yield work0.20.30.40.30.7
Bone: stiffness0.00.00.0-0.20.0
Bone: tissue strength0.20.20.50.1-0.7
Bone: trabecular number1.42.32.61.6-1.4
Bone: trabecular spacing1.01.31.7-1.30.9
Bone: trabecular thickness2.32.83.01.7-1.6
Bone: trabecular tissue density0.50.81.0-0.71.0
Breakpoint value in progressive ratio session0.50.50.80.9-0.5
Distance traveled before self-admin1.01.11.4-1.20.9
Distance traveled after self-admin0.10.10.1-0.4-0.2
Delta time in closed arm before/after self-admin1.51.51.7-1.31.1
Delta time in open arm before/after self-admin2.92.83.61.9-1.4
Diff in mean of infusions in LGA sessions0.10.10.20.40.1
Extinction: sum of active levers before priming3.03.13.3-1.81.7
Active lever presses in extinction session 60.10.10.10.1-0.4
Delta distance traveled before/after self-admin0.80.81.00.8-1.0
Delta ambulatory time before/after self-admin1.81.92.11.3-1.4
Time in closed arm before self-admin3.64.15.71.6-2.4
Time in closed arm after self-admin0.50.50.80.4-0.9
Time in open arm before self-admin3.43.64.0-1.82.0
Time in open arm after self-admin0.70.81.1-0.71.0
Sum of active levers in priming session hrs 5-60.10.10.20.4-0.0
Time to tail flick, vehicle, before self-admin0.10.10.20.5-0.1
Time to tail flick, vehicle, after self-admin1.21.32.01.4-0.8
Time to tail flick, test, before self-admin0.70.61.3-0.11.1
Time to tail flick, test, after self-admin0.30.30.40.5-0.6
Delta time to tail flick, vehicle, before/after SA0.80.81.21.1-0.7
Delta time to tail flick, test, before/after SA0.60.50.9-0.3-1.0
Ambulatory time before self-admin1.51.51.7-1.31.2
Ambulatory time after self-admin0.40.40.60.4-0.8
Total heroin consumption0.10.10.20.10.4
Area under the delay curve0.40.40.4-0.70.6
Delay disc. indifference point, 0s delay0.80.91.00.9-1.0
Delay disc. indifference point, 16s delay1.11.11.2-1.11.0
Delay disc. indifference point, 2s delay1.11.21.7-1.30.9
Delay disc. indifference point, 24s delay0.00.00.0-0.1-0.1
Delay disc. indifference point, 4s delay0.00.00.10.10.2
Delay disc. indifference point, 8s delay0.90.91.0-0.91.0
Delay discount exponential model param0.30.30.40.6-0.6
Delay discount hyperbolic model param0.30.30.40.6-0.6
Fecal boli incidents, locomotor time 11.92.03.21.8-1.0
Change in fecal boli incidents, locomotor task0.00.00.10.3-0.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.1-0.3
Bouts of movement, locomotor time 11.01.11.21.0-1.1
Total resting periods, locomotor time 10.60.60.80.7-0.9
Rest time, locomotor task time 11.01.11.21.1-1.0
Distance moved, locomotor task time 11.01.11.2-1.11.0
Vertical activity count, locomotor time 10.10.10.20.4-0.4
Time >=10cm from walls, locomotor time 20.40.40.4-0.60.6
Bouts of movement, locomotor time 20.20.20.4-0.60.2
Total resting periods, locomotor time 20.00.00.0-0.2-0.0
Rest time, locomotor task time 20.60.61.01.0-0.5
Distance moved, locomotor task time 22.32.73.5-1.91.4
Vertical activity count, locomotor time 20.00.00.10.2-0.1
Weight adjusted by age5.25.96.8-2.62.2
Seeking ratio, delayed vs. immediate footshock3.94.55.6-1.82.4
Locomotion in novel chamber0.50.60.8-0.90.7
Locomotion in novel chamber post-restriction0.20.20.3-0.2-0.6
Progressive ratio0.20.30.50.7-0.1
Food seeking constrained by brief footshock2.42.93.31.8-1.6
Seeking ratio, punishment vs. effort0.50.61.10.5-1.0
Run reversals in cocaine runway, females1.61.61.6-1.31.2
Run reversals in cocaine runway, males0.20.20.3-0.60.4
Latency to leave start box in cocaine runway0.20.20.3-0.10.6
Latency to leave start box in cocaine runway, F1.01.11.2-1.11.0
Latency to leave start box in cocaine runway, M3.23.15.12.3-1.0
Cd content in liver0.00.00.00.10.2
Co content in liver0.20.20.5-0.7-0.0
Cu content in liver0.10.10.1-0.40.2
Fe content in liver0.30.40.80.1-0.9
K content in liver0.40.40.6-0.80.3
Mg content in liver1.01.11.1-1.11.0
Mn content in liver0.91.11.4-0.91.2
Na content in liver0.10.10.2-0.40.1
Rb content in liver0.30.30.60.4-0.8
Se content in liver1.51.82.70.9-1.6
Sr content in liver0.00.00.1-0.0-0.2
Zn content in liver2.02.33.8-0.91.9