# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000069308 | 0.1500 | 0.0670 | 0.0e+00 | 0.129 | 0.128 | 0.118 | 0.121 | 3.8e-14 | 5.3e-14 | 4.7e-13 | 2.5e-13 |
2 | Adipose | intron excision ratio | chr7:113515646:113518656 | 0.0221 | 0.0146 | 3.2e-03 | 0.017 | 0.011 | 0.008 | 0.008 | 4.7e-03 | 1.8e-02 | 3.5e-02 | 4.3e-02 |
3 | Adipose | intron excision ratio | chr7:113518802:113518914 | 0.2425 | 0.0981 | 0.0e+00 | 0.186 | 0.202 | 0.176 | 0.187 | 3.1e-20 | 4.9e-22 | 4.5e-19 | 2.4e-20 |
4 | Adipose | intron excision ratio | chr7:113536908:113538623 | 0.0765 | 0.0374 | 2.0e-10 | 0.049 | 0.068 | 0.068 | 0.068 | 3.6e-06 | 4.7e-08 | 4.9e-08 | 5.4e-08 |
5 | Adipose | intron excision ratio | chr7:113538694:113541450 | 0.1575 | 0.0718 | 0.0e+00 | 0.094 | 0.116 | 0.117 | 0.101 | 1.3e-10 | 8.9e-13 | 7.1e-13 | 2.7e-11 |
6 | Adipose | mRNA stability | ENSRNOG00000069308 | 0.2890 | 0.0930 | 0.0e+00 | 0.262 | 0.264 | 0.264 | 0.266 | 5.7e-29 | 2.9e-29 | 3.0e-29 | 1.8e-29 |
7 | BLA | gene expression | ENSRNOG00000069308 | 0.7870 | 0.0722 | 0.0e+00 | 0.494 | 0.538 | 0.530 | 0.531 | 7.6e-30 | 1.4e-33 | 6.9e-33 | 5.8e-33 |
8 | BLA | mRNA stability | ENSRNOG00000069308 | 0.3400 | 0.1100 | 0.0e+00 | 0.270 | 0.311 | 0.297 | 0.281 | 9.0e-15 | 3.7e-17 | 2.5e-16 | 2.1e-15 |
9 | Brain | gene expression | ENSRNOG00000069308 | 0.6000 | 0.0860 | 0.0e+00 | 0.669 | 0.700 | 0.707 | 0.710 | 4.2e-83 | 2.4e-90 | 4.5e-92 | 7.8e-93 |
10 | Brain | intron excision ratio | chr7:113515646:113518656 | 0.0452 | 0.0319 | 1.7e-03 | 0.006 | 0.019 | 0.017 | 0.009 | 7.7e-02 | 6.9e-03 | 8.6e-03 | 4.3e-02 |
11 | Brain | mRNA stability | ENSRNOG00000069308 | 0.4108 | 0.1240 | 0.0e+00 | 0.418 | 0.436 | 0.439 | 0.440 | 1.1e-41 | 4.9e-44 | 1.8e-44 | 1.5e-44 |
12 | Eye | gene expression | ENSRNOG00000069308 | 0.6700 | 0.1800 | 3.6e-07 | 0.215 | 0.186 | 0.134 | 0.212 | 3.2e-04 | 8.2e-04 | 4.4e-03 | 3.5e-04 |
13 | IL | mRNA stability | ENSRNOG00000069308 | 0.7340 | 0.2390 | 1.4e-05 | 0.169 | 0.132 | 0.104 | 0.143 | 7.3e-05 | 4.7e-04 | 1.8e-03 | 2.7e-04 |
14 | LHb | gene expression | ENSRNOG00000069308 | 0.5156 | 0.1434 | 3.5e-11 | 0.344 | 0.335 | 0.314 | 0.345 | 5.3e-09 | 8.9e-09 | 3.1e-08 | 4.8e-09 |
15 | LHb | mRNA stability | ENSRNOG00000069308 | 0.4050 | 0.1720 | 2.4e-06 | 0.141 | 0.222 | 0.202 | 0.222 | 3.3e-04 | 5.3e-06 | 1.5e-05 | 5.4e-06 |
16 | Liver | gene expression | ENSRNOG00000069308 | 0.1300 | 0.0600 | 0.0e+00 | 0.111 | 0.111 | 0.103 | 0.104 | 2.8e-12 | 2.5e-12 | 1.6e-11 | 1.4e-11 |
17 | NAcc | gene expression | ENSRNOG00000069308 | 0.3800 | 0.1200 | 0.0e+00 | 0.345 | 0.355 | 0.354 | 0.356 | 1.4e-26 | 1.8e-27 | 2.5e-27 | 1.5e-27 |
18 | NAcc | mRNA stability | ENSRNOG00000069308 | 0.3165 | 0.0961 | 0.0e+00 | 0.376 | 0.389 | 0.401 | 0.402 | 2.2e-29 | 1.3e-30 | 8.8e-32 | 6.8e-32 |
19 | OFC | gene expression | ENSRNOG00000069308 | 0.1542 | 0.0968 | 9.5e-03 | 0.027 | 0.041 | 0.035 | 0.028 | 7.7e-02 | 3.8e-02 | 5.1e-02 | 7.3e-02 |
20 | OFC | mRNA stability | ENSRNOG00000069308 | 0.3397 | 0.1214 | 8.0e-07 | 0.253 | 0.197 | 0.197 | 0.224 | 1.0e-06 | 2.0e-05 | 1.9e-05 | 4.8e-06 |
21 | PL | gene expression | ENSRNOG00000069308 | 0.3425 | 0.1038 | 0.0e+00 | 0.331 | 0.345 | 0.329 | 0.337 | 7.1e-26 | 4.4e-27 | 1.1e-25 | 2.3e-26 |
22 | PL | mRNA stability | ENSRNOG00000069308 | 0.2882 | 0.0843 | 0.0e+00 | 0.378 | 0.408 | 0.393 | 0.395 | 3.2e-30 | 4.3e-33 | 1.2e-31 | 8.1e-32 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Right kidney weight | 14.5 | 41.4 | 48.1 | -6.0 | 6.3 | 6.3 | -6.4 | -5.6 | 6.8 | -6.9 | 6.6 | -6.5 | 6.6 | 6.2 | -6.7 | 6.5 | -6.2 | 5.8 | -6.8 | -6.7 | 6.9 | -6.2 | 6.5 | -6.2 | 6.6 |
Left kidney weight | 13.6 | 39.0 | 44.9 | -5.8 | 6.3 | 6.1 | -6.3 | -5.7 | 6.5 | -6.7 | 6.4 | -6.3 | 6.3 | 6.0 | -6.3 | 6.2 | -6.1 | 5.6 | -6.5 | -6.4 | 6.7 | -6.1 | 6.2 | -6.0 | 6.5 |
Context. condit. distance diff. score | 7.8 | 9.5 | 12.1 | -2.7 | 3.0 | 3.3 | -3.2 | -3.4 | 3.2 | -2.9 | 3.1 | -3.0 | 2.2 | 3.2 | -3.5 | 3.0 | -3.2 | 3.3 | -2.9 | -3.0 | 3.2 | -3.0 | 2.9 | -3.3 | 3.1 |
Time in closed arm before self-admin | 6.7 | 7.6 | 9.7 | 2.9 | -2.4 | -3.0 | 2.8 | 2.9 | -2.7 | 2.3 | -2.9 | 2.9 | -3.1 | -3.0 | 2.6 | -2.5 | 2.9 | -2.3 | 2.9 | 2.6 | -2.8 | 3.1 | -2.8 | 2.3 | -3.0 |
Time in novel zone, NPP test | 5.0 | 5.2 | 6.8 | -2.3 | 2.3 | 2.3 | -2.6 | -2.3 | 2.3 | -2.5 | 2.4 | -2.3 | 2.1 | 2.6 | -2.6 | 2.0 | -2.4 | 2.0 | -2.2 | -2.1 | 2.2 | -2.3 | 2.0 | -1.9 | 2.5 |
Pavlov. Cond. magazine entry latency | 4.9 | 5.6 | 7.7 | 2.0 | -1.9 | -2.7 | 2.8 | 2.8 | -2.6 | 2.1 | -2.3 | 2.2 | -1.5 | -2.8 | 1.8 | -2.4 | 2.4 | -2.7 | 2.2 | 2.1 | -2.7 | 2.6 | -2.1 | 2.8 | -2.2 |
Cu content in liver | 4.6 | 5.5 | 6.2 | 2.5 | -2.4 | -2.4 | 2.4 | 2.3 | -2.5 | 2.3 | -2.4 | 2.3 | -2.2 | -2.4 | 2.2 | -2.4 | 2.3 | -2.3 | 2.4 | 2.3 | -2.5 | 2.3 | -2.3 | 2.2 | -2.4 |
Retroperitoneal fat weight | 4.5 | 14.9 | 20.6 | -3.9 | 4.5 | 3.8 | -3.8 | -4.0 | 3.8 | -3.7 | 3.9 | -3.9 | 3.1 | 3.8 | -3.6 | 3.9 | -4.0 | 3.9 | -3.8 | -4.2 | 3.9 | -3.8 | 3.7 | -3.9 | 3.7 |
Bone: maximum diameter | 4.5 | 8.2 | 12.3 | -2.4 | 2.7 | 2.8 | -3.1 | -2.4 | 3.0 | -3.5 | 2.9 | -2.9 | 2.8 | 2.9 | -2.6 | 3.0 | -2.6 | 2.6 | -2.9 | -2.9 | 3.3 | -2.8 | 2.8 | -3.0 | 3.0 |
Bone: periosteal perimeter | 4.3 | 7.1 | 10.0 | -2.2 | 2.6 | 2.7 | -3.1 | -2.6 | 2.7 | -3.2 | 2.6 | -2.8 | 2.1 | 2.8 | -2.2 | 2.5 | -2.5 | 2.6 | -2.6 | -2.6 | 3.1 | -2.7 | 2.5 | -3.0 | 2.7 |
Epididymis fat weight | 4.2 | 9.7 | 12.7 | -2.8 | 3.2 | 3.3 | -3.3 | -3.6 | 3.1 | -2.9 | 3.1 | -3.2 | 2.2 | 3.3 | -2.8 | 2.9 | -3.3 | 3.4 | -2.9 | -3.1 | 3.2 | -3.2 | 3.1 | -3.3 | 3.0 |
Novelty place preference | 4.0 | 4.1 | 5.5 | -2.1 | 2.0 | 2.0 | -2.3 | -2.0 | 2.0 | -2.2 | 2.1 | -2.0 | 1.8 | 2.3 | -2.2 | 1.7 | -2.2 | 1.8 | -1.9 | -1.9 | 2.0 | -2.0 | 1.7 | -1.7 | 2.2 |
Seeking ratio, delayed vs. immediate footshock | 3.9 | 4.5 | 5.7 | 1.9 | -2.0 | -2.3 | 2.4 | 2.2 | -2.2 | 2.2 | -2.2 | 2.1 | -1.9 | -2.3 | 2.0 | -2.1 | 2.1 | -2.0 | 2.1 | 1.9 | -2.3 | 2.2 | -2.0 | 2.1 | -2.2 |
Pavlov. Cond. latency score | 3.8 | 4.8 | 7.3 | 2.0 | -1.8 | -2.6 | 2.5 | 2.7 | -2.3 | 1.8 | -2.1 | 2.2 | -1.3 | -2.7 | 1.2 | -2.0 | 2.3 | -2.6 | 1.9 | 2.0 | -2.4 | 2.5 | -2.1 | 2.5 | -2.0 |
Stereotopy head waving duration, day 3 | 3.6 | 4.3 | 6.8 | -2.1 | 1.9 | 1.9 | -2.3 | -1.9 | 2.2 | -2.6 | 2.1 | -2.1 | 1.8 | 2.0 | -2.1 | 2.2 | -1.8 | 1.9 | -2.0 | -2.0 | 2.4 | -1.9 | 1.8 | -2.3 | 2.1 |
Condit. Reinf. inactive responses | 3.3 | 3.9 | 5.3 | 1.9 | -2.3 | -1.9 | 2.1 | 1.7 | -1.8 | 2.1 | -2.0 | 2.1 | -2.2 | -2.0 | 1.9 | -1.6 | 1.9 | -1.5 | 2.0 | 2.1 | -1.8 | 2.1 | -1.9 | 1.7 | -2.1 |
Pavlov. Cond. lever-magazine prob. diff. | 3.2 | 4.1 | 6.1 | 1.8 | -1.6 | -2.4 | 2.3 | 2.4 | -2.2 | 1.7 | -2.0 | 2.0 | -1.3 | -2.5 | 1.2 | -1.9 | 2.1 | -2.4 | 1.9 | 1.8 | -2.2 | 2.3 | -1.9 | 2.2 | -1.9 |
Stereotopy head waving bouts, day 7 | 3.2 | 3.6 | 5.9 | -1.4 | 1.7 | 1.9 | -2.4 | -1.9 | 1.8 | -2.4 | 1.9 | -2.0 | 1.8 | 2.1 | -1.9 | 1.6 | -1.8 | 1.4 | -1.8 | -1.6 | 2.2 | -2.1 | 1.6 | -2.0 | 2.1 |
Na content in liver | 3.2 | 3.4 | 4.0 | 1.8 | -1.8 | -1.9 | 1.9 | 1.8 | -2.0 | 1.9 | -1.9 | 1.9 | -1.8 | -1.8 | 1.5 | -1.9 | 1.8 | -1.7 | 1.9 | 1.8 | -2.0 | 1.9 | -1.9 | 1.8 | -1.9 |
Liver weight, right | 3.1 | 5.1 | 8.0 | -2.2 | 2.3 | 2.5 | -2.6 | -2.8 | 2.3 | -2.0 | 2.2 | -2.3 | 1.2 | 2.5 | -1.7 | 2.0 | -2.4 | 2.5 | -2.0 | -2.1 | 2.3 | -2.4 | 1.9 | -2.6 | 2.2 |
Pavlov. Cond. index score | 3.1 | 4.0 | 6.1 | 1.8 | -1.6 | -2.4 | 2.3 | 2.5 | -2.2 | 1.6 | -2.0 | 2.0 | -1.2 | -2.5 | 1.1 | -1.8 | 2.1 | -2.4 | 1.8 | 1.8 | -2.2 | 2.3 | -1.9 | 2.2 | -1.8 |
Total zone transitions, hab. session 1 | 3.1 | 4.4 | 7.1 | 2.5 | -2.2 | -1.8 | 1.8 | 1.9 | -2.3 | 2.4 | -2.0 | 2.1 | -1.1 | -1.9 | 2.1 | -2.4 | 2.1 | -2.7 | 2.0 | 2.4 | -2.0 | 1.5 | -2.3 | 2.6 | -1.8 |
Delta time to tail flick, test, before/after SA | 3.1 | 2.8 | 3.9 | 1.9 | -2.0 | -1.8 | 1.7 | 1.8 | -1.8 | 1.5 | -1.7 | 1.6 | -1.5 | -1.8 | 1.1 | -1.4 | 1.8 | -1.6 | 1.7 | 1.7 | -1.7 | 1.8 | -1.6 | 1.6 | -1.7 |
Pavlov. Cond. intertrial magazine entries | 3.0 | 3.9 | 5.8 | -2.0 | 1.8 | 2.0 | -1.7 | -1.9 | 2.3 | -1.7 | 2.0 | -1.8 | 1.6 | 1.8 | -2.1 | 2.4 | -1.8 | 2.2 | -2.1 | -2.0 | 2.1 | -1.8 | 2.0 | -2.1 | 1.8 |
Locomotion distance, session 2 | 2.9 | 4.2 | 6.3 | 1.9 | -2.0 | -2.1 | 2.1 | 2.4 | -2.2 | 2.0 | -2.0 | 2.0 | -0.9 | -2.3 | 1.9 | -1.9 | 2.2 | -2.5 | 1.7 | 2.0 | -2.0 | 1.9 | -1.9 | 2.4 | -1.9 |
Bone: maximum moment | 2.9 | 5.1 | 7.2 | -2.4 | 2.5 | 2.0 | -2.1 | -1.6 | 2.3 | -2.7 | 2.3 | -2.3 | 2.6 | 1.9 | -2.3 | 2.4 | -2.0 | 1.8 | -2.5 | -2.5 | 2.4 | -2.0 | 2.4 | -2.1 | 2.3 |
Novel to familiar place preference ratio | 2.8 | 3.0 | 4.3 | -1.8 | 1.7 | 1.7 | -2.0 | -1.7 | 1.7 | -2.0 | 1.8 | -1.7 | 1.6 | 2.0 | -2.1 | 1.4 | -1.8 | 1.5 | -1.6 | -1.6 | 1.7 | -1.7 | 1.4 | -1.4 | 1.9 |
Total zone transitions, NPP test | 2.6 | 3.7 | 6.6 | 2.4 | -2.2 | -1.6 | 1.6 | 1.9 | -2.1 | 2.1 | -1.8 | 1.9 | -0.7 | -1.8 | 1.3 | -2.0 | 2.0 | -2.6 | 1.7 | 2.3 | -1.8 | 1.3 | -2.0 | 2.4 | -1.5 |
Bone: maximum force | 2.6 | 4.6 | 6.1 | -2.3 | 2.4 | 1.8 | -1.9 | -1.5 | 2.2 | -2.5 | 2.1 | -2.2 | 2.4 | 1.8 | -2.3 | 2.3 | -1.9 | 1.8 | -2.3 | -2.4 | 2.3 | -1.9 | 2.3 | -2.0 | 2.2 |
Pavlov. Cond. magazine entry number | 2.5 | 3.1 | 4.8 | -1.5 | 1.2 | 2.1 | -2.1 | -2.2 | 2.0 | -1.5 | 1.7 | -1.6 | 0.9 | 2.1 | -1.0 | 1.8 | -1.7 | 2.1 | -1.5 | -1.4 | 2.1 | -1.9 | 1.5 | -2.2 | 1.5 |
Locomotion velocity, session 8 | 2.5 | 3.0 | 6.7 | -1.8 | 1.4 | 1.6 | -1.8 | -1.4 | 1.8 | -1.9 | 1.8 | -1.6 | 2.1 | 1.5 | -2.6 | 2.0 | -1.4 | 1.2 | -1.9 | -1.5 | 1.9 | -1.7 | 1.6 | -1.5 | 1.9 |
Latency to leave start box in cocaine runway, M | 2.4 | 2.3 | 3.9 | -1.9 | 1.8 | 1.4 | -1.2 | -1.6 | 1.4 | -1.3 | 1.5 | -1.6 | 1.0 | 1.4 | -2.0 | 1.6 | -1.7 | 1.8 | -1.4 | -1.7 | 1.3 | -1.2 | 1.7 | -1.5 | 1.4 |
Short access total infusions | 2.3 | 2.5 | 4.3 | -1.2 | 1.4 | 1.4 | -1.1 | -0.9 | 1.7 | -1.7 | 1.5 | -1.7 | 1.7 | 1.3 | -1.9 | 1.9 | -1.4 | 1.7 | -1.8 | -1.9 | 1.6 | -1.3 | 2.1 | -1.7 | 1.4 |
Compulsive drug intake | 2.3 | 2.3 | 4.5 | 1.3 | -1.6 | -1.4 | 1.4 | 1.5 | -1.6 | 1.7 | -1.4 | 1.5 | -0.5 | -1.4 | 1.7 | -1.7 | 1.5 | -2.1 | 1.3 | 1.6 | -1.6 | 1.1 | -1.6 | 2.1 | -1.2 |
Stereotopy head waving duration, day 7 | 2.3 | 2.8 | 4.4 | -1.3 | 1.4 | 1.7 | -2.1 | -1.8 | 1.6 | -2.0 | 1.6 | -1.8 | 1.1 | 2.0 | -1.6 | 1.4 | -1.7 | 1.6 | -1.4 | -1.4 | 1.9 | -1.7 | 1.3 | -1.9 | 1.7 |
Bone: endosteal perimeter | 2.3 | 4.6 | 7.6 | -1.7 | 1.9 | 2.2 | -2.8 | -2.2 | 2.2 | -2.6 | 2.1 | -2.2 | 1.6 | 2.4 | -1.9 | 1.9 | -2.0 | 2.0 | -1.9 | -1.9 | 2.6 | -2.3 | 1.7 | -2.5 | 2.2 |
Heart weight | 2.2 | 3.1 | 5.5 | -1.3 | 1.3 | 1.5 | -1.5 | -1.4 | 2.1 | -2.1 | 1.8 | -1.7 | 1.1 | 1.7 | -2.4 | 2.1 | -1.6 | 2.3 | -1.7 | -1.9 | 1.9 | -1.1 | 1.9 | -2.2 | 1.5 |
Conditioned locomotion | 2.2 | 2.6 | 4.2 | -1.9 | 1.2 | 1.6 | -1.5 | -0.9 | 1.7 | -1.7 | 1.6 | -1.7 | 2.1 | 1.5 | -1.6 | 1.6 | -1.3 | 1.3 | -1.9 | -1.7 | 1.6 | -1.7 | 1.8 | -1.5 | 1.6 |
Locomotion velocity, NPP test | 2.2 | 3.1 | 4.3 | 1.9 | -1.9 | -1.6 | 1.6 | 1.7 | -1.9 | 1.9 | -1.7 | 1.8 | -1.1 | -1.7 | 1.5 | -1.9 | 1.8 | -2.1 | 1.7 | 2.0 | -1.7 | 1.4 | -1.8 | 1.9 | -1.6 |
Locomotor activity | 2.1 | 3.3 | 4.4 | -2.0 | 1.9 | 1.7 | -2.0 | -1.7 | 1.8 | -2.1 | 1.9 | -1.9 | 1.6 | 2.0 | -1.8 | 1.7 | -1.8 | 1.6 | -1.8 | -1.7 | 2.0 | -1.7 | 1.6 | -1.8 | 1.9 |
Locomotion distance, session 1 | 2.1 | 2.8 | 5.3 | 1.9 | -1.7 | -1.4 | 1.3 | 1.7 | -1.9 | 1.8 | -1.6 | 1.6 | -0.6 | -1.5 | 1.7 | -1.9 | 1.7 | -2.3 | 1.5 | 1.9 | -1.5 | 1.0 | -1.8 | 2.1 | -1.3 |
Degree of sensitization distance | 2.1 | 2.1 | 3.9 | -1.9 | 1.7 | 1.2 | -0.9 | -1.3 | 1.7 | -1.5 | 1.4 | -1.3 | 0.6 | 1.1 | -1.3 | 1.9 | -1.4 | 2.0 | -1.4 | -1.8 | 1.2 | -0.8 | 1.6 | -1.8 | 1.1 |
Degree of sensitization stereotypy | 2.1 | 2.3 | 4.0 | -1.0 | 1.3 | 1.6 | -2.0 | -1.6 | 1.4 | -1.8 | 1.5 | -1.7 | 1.4 | 1.9 | -1.5 | 1.1 | -1.5 | 1.2 | -1.4 | -1.3 | 1.7 | -1.8 | 1.3 | -1.5 | 1.7 |
Mean num. licks in bursts | 2.0 | 2.4 | 3.0 | -1.7 | 1.7 | 1.5 | -1.5 | -1.6 | 1.5 | -1.5 | 1.6 | -1.6 | 1.3 | 1.6 | -1.6 | 1.7 | -1.6 | 1.7 | -1.6 | -1.6 | 1.5 | -1.4 | 1.5 | -1.6 | 1.5 |
Social time | 2.0 | 2.7 | 3.2 | 1.6 | -1.4 | -1.7 | 1.8 | 1.7 | -1.5 | 1.8 | -1.7 | 1.7 | -1.5 | -1.7 | 1.6 | -1.4 | 1.7 | -1.5 | 1.6 | 1.6 | -1.5 | 1.7 | -1.6 | 1.6 | -1.8 |
Bone: elastic work | 2.0 | 2.7 | 4.7 | -1.8 | 1.6 | 1.4 | -1.7 | -1.3 | 1.6 | -2.2 | 1.6 | -1.6 | 1.4 | 1.6 | -1.9 | 1.6 | -1.5 | 1.5 | -1.6 | -1.7 | 1.8 | -1.4 | 1.6 | -1.7 | 1.7 |
Bone: trabecular tissue density | 1.9 | 2.7 | 4.1 | 1.6 | -1.6 | -1.9 | 1.8 | 1.8 | -1.5 | 1.3 | -1.6 | 1.8 | -1.6 | -1.7 | 1.3 | -1.4 | 1.8 | -1.5 | 1.6 | 1.6 | -1.5 | 2.0 | -1.8 | 1.6 | -1.7 |
Food seeking constrained by brief footshock | 1.9 | 2.3 | 2.7 | -1.4 | 1.3 | 1.5 | -1.5 | -1.3 | 1.6 | -1.6 | 1.5 | -1.7 | 1.6 | 1.5 | -1.2 | 1.4 | -1.5 | 1.4 | -1.6 | -1.6 | 1.6 | -1.6 | 1.6 | -1.6 | 1.5 |
Total sessions with >9 infusions | 1.8 | 2.0 | 3.4 | -0.9 | 1.4 | 1.3 | -1.2 | -0.8 | 1.5 | -1.6 | 1.4 | -1.5 | 1.8 | 1.2 | -1.6 | 1.5 | -1.2 | 1.2 | -1.7 | -1.7 | 1.4 | -1.4 | 1.7 | -1.3 | 1.4 |
Short access day 1 total infusions | 1.8 | 1.9 | 2.9 | -0.8 | 0.9 | 1.3 | -1.2 | -0.8 | 1.5 | -1.6 | 1.3 | -1.4 | 1.6 | 1.2 | -1.7 | 1.7 | -1.1 | 1.3 | -1.6 | -1.5 | 1.5 | -1.2 | 1.7 | -1.5 | 1.3 |
Bone: periosteal estimation | 1.8 | 3.6 | 6.1 | -1.6 | 1.7 | 1.8 | -2.3 | -1.7 | 1.9 | -2.5 | 1.9 | -1.9 | 1.7 | 2.0 | -1.8 | 1.8 | -1.6 | 1.5 | -1.8 | -1.7 | 2.4 | -1.9 | 1.6 | -2.0 | 2.1 |
Body weight | 1.7 | 7.2 | 9.3 | -2.6 | 2.9 | 2.5 | -2.7 | -2.3 | 2.7 | -3.1 | 2.7 | -2.8 | 2.3 | 2.7 | -2.6 | 2.6 | -2.6 | 2.7 | -2.7 | -2.9 | 2.7 | -2.5 | 2.8 | -2.8 | 2.6 |
Std. dev. time between licks in bursts | 1.7 | 2.0 | 3.4 | 1.6 | -1.4 | -1.6 | 1.4 | 1.8 | -1.5 | 1.0 | -1.4 | 1.4 | -0.7 | -1.6 | 1.2 | -1.2 | 1.6 | -1.7 | 1.2 | 1.3 | -1.4 | 1.5 | -1.2 | 1.4 | -1.3 |
Locomotor testing rearing | 1.7 | 2.7 | 3.6 | -1.5 | 1.6 | 1.7 | -1.7 | -1.7 | 1.8 | -1.6 | 1.6 | -1.7 | 1.1 | 1.9 | -1.4 | 1.6 | -1.6 | 1.9 | -1.6 | -1.5 | 1.8 | -1.6 | 1.6 | -1.8 | 1.5 |
Locomotion velocity, hab. session 1 | 1.7 | 2.5 | 4.2 | 2.0 | -1.9 | -1.2 | 1.1 | 1.2 | -1.7 | 1.7 | -1.5 | 1.6 | -0.9 | -1.4 | 1.5 | -1.8 | 1.6 | -2.1 | 1.5 | 1.9 | -1.3 | 1.0 | -1.8 | 1.8 | -1.2 |
Delta time in closed arm before/after self-admin | 1.7 | 1.7 | 3.0 | -1.1 | 1.0 | 1.3 | -1.1 | -1.2 | 1.4 | -1.0 | 1.3 | -1.2 | 1.4 | 1.2 | -1.7 | 1.6 | -1.1 | 1.2 | -1.5 | -1.2 | 1.3 | -1.3 | 1.3 | -1.3 | 1.2 |
Delay disc. indifference point, 16s delay | 1.7 | 1.7 | 2.7 | 1.0 | -1.0 | -1.2 | 1.4 | 1.3 | -1.5 | 1.6 | -1.3 | 1.2 | -0.7 | -1.4 | 1.4 | -1.3 | 1.3 | -1.5 | 1.2 | 1.3 | -1.5 | 1.1 | -1.2 | 1.7 | -1.2 |
Delay discounting water rate 18 sec | 1.6 | 2.2 | 3.8 | 1.6 | -1.3 | -1.6 | 1.3 | 1.8 | -1.5 | 1.1 | -1.4 | 1.5 | -0.7 | -1.4 | 1.2 | -1.7 | 1.6 | -2.0 | 1.3 | 1.5 | -1.2 | 1.4 | -1.8 | 1.8 | -1.2 |
Condit. Reinf. active responses | 1.6 | 2.0 | 2.7 | 1.4 | -1.5 | -1.4 | 1.6 | 1.4 | -1.3 | 1.5 | -1.4 | 1.6 | -1.2 | -1.6 | 1.4 | -1.1 | 1.5 | -1.3 | 1.3 | 1.4 | -1.2 | 1.5 | -1.3 | 1.2 | -1.4 |
Pavlov. Cond. lever contacts | 1.6 | 1.9 | 2.7 | 1.2 | -1.4 | -1.4 | 1.6 | 1.3 | -1.2 | 1.6 | -1.4 | 1.5 | -1.3 | -1.6 | 1.6 | -1.0 | 1.4 | -1.2 | 1.3 | 1.3 | -1.2 | 1.5 | -1.3 | 1.2 | -1.5 |
Bone: cortical area | 1.6 | 2.5 | 3.8 | -1.4 | 1.5 | 1.5 | -1.6 | -1.2 | 1.6 | -2.0 | 1.6 | -1.7 | 1.6 | 1.5 | -1.2 | 1.6 | -1.4 | 1.4 | -1.6 | -1.7 | 1.8 | -1.5 | 1.7 | -1.7 | 1.6 |
Food consumed during 24 hour testing period | 1.5 | 1.8 | 2.8 | -1.6 | 1.7 | 1.2 | -1.2 | -0.9 | 1.4 | -1.5 | 1.3 | -1.4 | 1.4 | 1.1 | -1.2 | 1.4 | -1.2 | 1.2 | -1.5 | -1.5 | 1.4 | -1.2 | 1.3 | -1.3 | 1.3 |
Locomotion velocity, hab. session 2 | 1.5 | 2.0 | 2.9 | 1.7 | -1.7 | -1.4 | 1.3 | 1.6 | -1.4 | 1.3 | -1.4 | 1.5 | -0.8 | -1.5 | 1.0 | -1.3 | 1.7 | -1.7 | 1.2 | 1.6 | -1.3 | 1.3 | -1.4 | 1.4 | -1.3 |
Pavlov. Cond. change in total contacts | 1.5 | 1.6 | 2.6 | 1.0 | -1.2 | -1.3 | 1.5 | 1.6 | -1.1 | 1.3 | -1.3 | 1.4 | -0.6 | -1.6 | 1.4 | -0.9 | 1.4 | -1.4 | 1.0 | 1.1 | -1.2 | 1.3 | -1.0 | 1.3 | -1.3 |
Bone: final moment | 1.5 | 2.5 | 4.2 | -1.8 | 2.0 | 1.2 | -1.3 | -0.9 | 1.5 | -1.9 | 1.6 | -1.6 | 2.0 | 1.2 | -1.6 | 1.6 | -1.4 | 1.1 | -1.8 | -1.9 | 1.6 | -1.4 | 1.7 | -1.3 | 1.6 |
Bone: stiffness | 1.5 | 2.4 | 3.5 | -1.5 | 1.7 | 1.3 | -1.3 | -1.1 | 1.6 | -1.9 | 1.5 | -1.6 | 1.5 | 1.2 | -1.5 | 1.8 | -1.4 | 1.5 | -1.6 | -1.8 | 1.7 | -1.3 | 1.8 | -1.7 | 1.4 |
Mg content in liver | 1.5 | 1.6 | 2.8 | 1.2 | -1.2 | -1.5 | 1.5 | 1.7 | -1.3 | 1.0 | -1.2 | 1.2 | -0.7 | -1.7 | 0.8 | -1.0 | 1.5 | -1.5 | 1.1 | 1.0 | -1.2 | 1.4 | -1.0 | 1.3 | -1.2 |
BMI with tail | 1.4 | 4.6 | 6.4 | -2.3 | 2.0 | 1.9 | -1.9 | -1.7 | 2.3 | -2.4 | 2.1 | -2.0 | 1.5 | 2.1 | -2.2 | 2.5 | -2.0 | 2.5 | -2.2 | -2.4 | 2.3 | -1.7 | 2.4 | -2.5 | 1.8 |
Length without tail | 1.4 | 3.1 | 5.7 | -2.0 | 2.3 | 1.6 | -1.7 | -1.4 | 1.5 | -1.7 | 1.8 | -1.8 | 2.4 | 1.4 | -1.7 | 1.5 | -1.7 | 1.0 | -1.9 | -1.9 | 1.7 | -1.9 | 1.8 | -1.2 | 1.9 |
Pavlov. Cond. response bias | 1.4 | 2.0 | 3.8 | 1.2 | -1.2 | -1.8 | 1.6 | 2.0 | -1.5 | 0.9 | -1.4 | 1.3 | -0.7 | -1.8 | 0.3 | -1.2 | 1.6 | -1.8 | 1.2 | 1.2 | -1.4 | 1.7 | -1.3 | 1.5 | -1.3 |
Pavlov. Cond. lever latency | 1.3 | 1.8 | 3.0 | -1.4 | 1.3 | 1.6 | -1.3 | -1.7 | 1.4 | -0.8 | 1.3 | -1.4 | 0.9 | 1.7 | -0.2 | 1.1 | -1.6 | 1.6 | -1.2 | -1.3 | 1.2 | -1.6 | 1.4 | -1.3 | 1.2 |
Total locomotion distance, NPP test | 1.3 | 1.9 | 3.4 | 1.4 | -1.5 | -1.3 | 1.2 | 1.5 | -1.5 | 1.4 | -1.3 | 1.4 | -0.6 | -1.4 | 0.8 | -1.5 | 1.5 | -1.8 | 1.2 | 1.6 | -1.3 | 1.1 | -1.4 | 1.7 | -1.1 |
Bone: cortical porosity | 1.3 | 1.4 | 2.4 | -1.3 | 1.1 | 1.0 | -1.2 | -1.1 | 1.3 | -1.5 | 1.1 | -1.1 | 0.6 | 1.1 | -0.9 | 1.2 | -1.1 | 1.3 | -1.0 | -1.1 | 1.4 | -0.9 | 1.0 | -1.6 | 1.0 |
Bone: final force | 1.3 | 2.2 | 3.8 | -1.8 | 1.9 | 1.2 | -1.2 | -0.9 | 1.4 | -1.7 | 1.5 | -1.5 | 1.9 | 1.1 | -1.5 | 1.5 | -1.3 | 1.1 | -1.7 | -1.8 | 1.4 | -1.3 | 1.6 | -1.2 | 1.5 |
Zn content in liver | 1.3 | 1.4 | 2.5 | 1.6 | -1.3 | -1.2 | 1.0 | 1.2 | -1.2 | 1.0 | -1.2 | 1.2 | -1.0 | -1.1 | 1.0 | -1.3 | 1.2 | -1.3 | 1.2 | 1.3 | -1.2 | 1.1 | -1.3 | 1.1 | -1.1 |
Pavlov. Cond. lever contacts | 1.2 | 1.7 | 3.0 | 1.2 | -1.2 | -1.6 | 1.4 | 1.7 | -1.3 | 0.8 | -1.3 | 1.4 | -0.8 | -1.7 | 0.1 | -1.0 | 1.6 | -1.6 | 1.2 | 1.2 | -1.2 | 1.6 | -1.3 | 1.2 | -1.2 |
Short access total locomotion | 1.2 | 1.2 | 2.4 | -1.0 | 0.8 | 0.9 | -0.7 | -0.6 | 1.3 | -1.2 | 1.0 | -1.1 | 0.8 | 0.8 | -1.4 | 1.4 | -0.9 | 1.5 | -1.2 | -1.4 | 1.2 | -0.8 | 1.5 | -1.5 | 0.7 |
Total locomotion distance, hab. session 1 | 1.2 | 1.7 | 3.2 | 1.7 | -1.7 | -0.9 | 0.7 | 0.9 | -1.4 | 1.4 | -1.2 | 1.4 | -0.7 | -1.0 | 1.2 | -1.6 | 1.3 | -1.8 | 1.3 | 1.7 | -1.0 | 0.7 | -1.6 | 1.5 | -0.9 |
Pavlov. Cond. lever latency | 1.2 | 1.6 | 2.7 | -1.0 | 1.3 | 1.3 | -1.4 | -1.2 | 1.2 | -1.3 | 1.3 | -1.4 | 1.1 | 1.5 | -1.6 | 1.0 | -1.3 | 1.3 | -1.2 | -1.2 | 1.1 | -1.3 | 1.2 | -1.1 | 1.3 |
Pavlov. Cond. intertrial magazine entries | 1.2 | 1.4 | 2.1 | 1.0 | -1.1 | -1.3 | 1.2 | 1.5 | -1.3 | 1.0 | -1.1 | 1.1 | -0.6 | -1.2 | 1.1 | -1.3 | 1.2 | -1.5 | 1.1 | 1.2 | -1.3 | 1.2 | -1.1 | 1.5 | -1.0 |
Time to tail flick, test, after self-admin | 1.2 | 1.2 | 2.5 | 1.1 | -1.6 | -1.0 | 1.0 | 0.9 | -1.2 | 1.2 | -1.2 | 1.1 | -1.1 | -1.0 | 0.6 | -1.0 | 1.2 | -1.0 | 1.1 | 1.2 | -1.2 | 1.0 | -1.2 | 1.0 | -1.2 |
Condit. Reinf. inactive responses | 1.1 | 1.4 | 2.2 | -0.8 | 0.8 | 1.3 | -1.4 | -1.2 | 1.2 | -1.0 | 1.2 | -1.1 | 1.5 | 1.2 | -1.2 | 1.4 | -1.0 | 0.8 | -1.3 | -1.0 | 1.4 | -1.4 | 1.0 | -1.1 | 1.3 |
Baseline Anxiety | 1.1 | 1.1 | 1.9 | 1.1 | -1.2 | -0.9 | 0.8 | 1.0 | -1.1 | 1.1 | -1.1 | 1.2 | -0.8 | -0.9 | 1.1 | -1.0 | 1.3 | -1.2 | 1.0 | 1.4 | -1.0 | 0.8 | -1.1 | 1.1 | -1.0 |
Short access day 1 total inactive lever presses | 1.1 | 1.3 | 2.7 | -1.0 | 0.6 | 0.9 | -1.0 | -0.4 | 1.1 | -1.5 | 1.1 | -1.1 | 1.6 | 1.0 | -1.5 | 1.4 | -0.8 | 0.8 | -1.4 | -1.2 | 1.2 | -0.9 | 1.3 | -1.0 | 1.2 |
Number of responses in last shaping day | 1.1 | 1.2 | 2.2 | 1.3 | -0.9 | -1.2 | 1.4 | 1.3 | -0.9 | 1.0 | -1.1 | 1.2 | -0.9 | -1.5 | 0.4 | -0.3 | 1.2 | -0.8 | 0.9 | 0.8 | -1.2 | 1.4 | -0.8 | 0.8 | -1.3 |
Bone: marrow area | 1.1 | 2.3 | 4.6 | -1.1 | 1.2 | 1.5 | -2.1 | -1.6 | 1.5 | -2.0 | 1.5 | -1.4 | 1.3 | 1.7 | -1.8 | 1.4 | -1.2 | 1.0 | -1.4 | -1.1 | 2.0 | -1.6 | 0.9 | -1.6 | 1.7 |
Cd content in liver | 1.1 | 1.2 | 1.8 | -0.7 | 0.8 | 1.2 | -1.2 | -1.1 | 1.3 | -1.0 | 1.1 | -0.9 | 0.6 | 1.3 | -1.4 | 1.1 | -1.0 | 1.3 | -1.0 | -0.9 | 1.3 | -1.1 | 0.9 | -1.2 | 1.0 |
Liver weight, left | 1.0 | 1.6 | 2.5 | -0.9 | 1.1 | 1.4 | -1.6 | -1.6 | 1.2 | -1.3 | 1.3 | -1.3 | 0.8 | 1.6 | -1.1 | 1.0 | -1.4 | 1.3 | -1.1 | -1.1 | 1.4 | -1.4 | 1.0 | -1.5 | 1.3 |
Indifference point function ln k | 1.0 | 1.5 | 2.5 | -1.2 | 1.5 | 1.1 | -1.2 | -1.1 | 1.2 | -1.4 | 1.2 | -1.1 | 0.5 | 1.2 | -1.6 | 1.2 | -1.1 | 1.5 | -1.0 | -1.2 | 1.3 | -0.9 | 1.2 | -1.5 | 1.0 |
Indifference point function log k | 1.0 | 1.5 | 2.5 | -1.2 | 1.5 | 1.1 | -1.2 | -1.1 | 1.2 | -1.4 | 1.2 | -1.1 | 0.5 | 1.2 | -1.6 | 1.2 | -1.1 | 1.5 | -1.0 | -1.2 | 1.3 | -0.9 | 1.2 | -1.5 | 1.0 |
Pavlov. Cond. change in total contacts | 1.0 | 1.3 | 4.0 | 0.8 | -0.7 | -1.6 | 1.4 | 2.0 | -1.2 | 0.3 | -1.0 | 1.0 | -0.0 | -1.6 | -0.1 | -0.7 | 1.4 | -1.6 | 0.7 | 0.7 | -1.3 | 1.5 | -0.9 | 1.3 | -0.9 |
Intermittent access day 1 total infusions | 1.0 | 1.1 | 1.9 | -0.7 | 0.7 | 1.1 | -0.9 | -0.7 | 1.1 | -1.1 | 1.1 | -1.2 | 1.3 | 1.0 | -1.0 | 1.0 | -1.0 | 1.0 | -1.2 | -1.2 | 1.2 | -1.1 | 1.4 | -1.0 | 1.1 |
Locomotion distance, session 8 | 1.0 | 1.5 | 3.0 | -0.9 | 0.9 | 1.3 | -1.3 | -1.4 | 1.3 | -1.1 | 1.2 | -1.1 | 0.8 | 1.1 | -1.7 | 1.3 | -1.1 | 1.2 | -1.1 | -0.9 | 1.4 | -1.2 | 1.1 | -1.4 | 1.2 |
Pavlov. Cond. magazine entry latency | 1.0 | 1.3 | 2.5 | 1.0 | -0.9 | -1.2 | 1.4 | 1.3 | -1.0 | 1.3 | -1.2 | 1.3 | -0.8 | -1.3 | 1.6 | -0.8 | 1.2 | -1.1 | 0.9 | 0.9 | -1.1 | 1.2 | -1.0 | 1.2 | -1.2 |
Pavlov. Cond. response bias | 1.0 | 1.2 | 2.3 | 0.9 | -0.9 | -1.1 | 1.4 | 1.2 | -1.0 | 1.3 | -1.1 | 1.2 | -0.8 | -1.4 | 1.5 | -0.7 | 1.1 | -1.0 | 0.9 | 0.9 | -1.0 | 1.1 | -0.9 | 1.0 | -1.2 |
Bone: endosteal estimation | 1.0 | 2.1 | 4.3 | -1.0 | 1.1 | 1.5 | -2.1 | -1.5 | 1.5 | -1.9 | 1.5 | -1.3 | 1.2 | 1.6 | -1.7 | 1.3 | -1.2 | 1.0 | -1.3 | -1.1 | 2.0 | -1.5 | 0.9 | -1.6 | 1.7 |
Bone: trabecular spacing | 1.0 | 1.4 | 2.2 | -1.0 | 1.4 | 1.1 | -1.0 | -0.8 | 1.1 | -1.2 | 1.1 | -1.2 | 1.5 | 1.0 | -1.3 | 1.3 | -1.0 | 0.9 | -1.4 | -1.3 | 1.0 | -1.2 | 1.4 | -1.1 | 1.1 |
Distance moved, locomotor task time 2 | 1.0 | 1.1 | 2.4 | -0.5 | 0.7 | 1.2 | -1.2 | -1.3 | 1.2 | -1.1 | 1.0 | -1.0 | 0.4 | 1.3 | -1.0 | 1.3 | -1.0 | 1.4 | -0.9 | -0.9 | 1.2 | -1.0 | 0.9 | -1.6 | 0.9 |
Tibia length | 0.9 | 2.5 | 5.0 | -1.6 | 1.7 | 1.4 | -1.6 | -1.1 | 1.4 | -1.8 | 1.6 | -1.7 | 2.2 | 1.4 | -1.5 | 1.3 | -1.4 | 0.9 | -1.8 | -1.7 | 1.6 | -1.7 | 1.7 | -1.2 | 1.8 |
Light reinforcement 2 | 0.9 | 1.1 | 2.1 | -0.9 | 1.0 | 1.1 | -1.1 | -1.3 | 1.2 | -1.0 | 1.0 | -1.1 | 0.4 | 0.9 | -0.5 | 1.1 | -1.1 | 1.3 | -0.9 | -1.0 | 1.2 | -1.0 | 1.0 | -1.5 | 0.9 |
Reaction time trials on left | 0.9 | 1.3 | 2.8 | 1.3 | -1.0 | -0.9 | 0.8 | 0.8 | -1.3 | 1.3 | -1.1 | 0.9 | -0.9 | -0.7 | 1.5 | -1.7 | 0.9 | -1.3 | 1.2 | 1.2 | -1.1 | 0.6 | -1.2 | 1.3 | -1.0 |
Reaction time trials completed | 0.9 | 1.3 | 2.8 | 1.3 | -1.0 | -0.9 | 0.8 | 0.8 | -1.3 | 1.3 | -1.1 | 0.9 | -0.9 | -0.7 | 1.5 | -1.7 | 0.9 | -1.3 | 1.2 | 1.2 | -1.1 | 0.6 | -1.2 | 1.3 | -1.0 |
Stereotopy head waving bouts, day 3 | 0.9 | 1.0 | 1.7 | -1.1 | 1.1 | 0.9 | -1.1 | -0.8 | 1.0 | -1.3 | 1.0 | -1.0 | 1.1 | 0.9 | -1.0 | 1.0 | -0.9 | 0.7 | -1.0 | -1.0 | 1.1 | -0.9 | 0.8 | -1.0 | 1.1 |
Condit. Reinf. lever presses | 0.9 | 1.2 | 1.8 | 1.3 | -1.3 | -1.1 | 1.2 | 1.1 | -1.0 | 1.1 | -1.1 | 1.2 | -0.9 | -1.3 | 1.2 | -0.7 | 1.3 | -1.0 | 1.0 | 1.1 | -0.9 | 1.1 | -0.9 | 0.8 | -1.2 |
Total zone transitions, hab. session 2 | 0.9 | 1.2 | 2.8 | 1.5 | -1.3 | -1.0 | 0.9 | 1.4 | -1.0 | 1.0 | -1.0 | 1.1 | 0.1 | -1.2 | 0.5 | -0.8 | 1.4 | -1.7 | 0.7 | 1.3 | -0.9 | 0.8 | -1.0 | 1.4 | -0.8 |
Delay disc. indifference point, 0s delay | 0.9 | 1.0 | 2.3 | -0.6 | 0.9 | 0.9 | -0.8 | -1.0 | 1.2 | -1.0 | 0.9 | -0.8 | 0.2 | 0.9 | -1.1 | 1.3 | -0.9 | 1.4 | -0.8 | -1.0 | 1.0 | -0.6 | 1.1 | -1.5 | 0.7 |
Locomotion in novel chamber post-restriction | 0.9 | 1.0 | 1.6 | 0.9 | -1.3 | -0.9 | 1.0 | 0.7 | -1.0 | 1.2 | -1.1 | 1.0 | -1.2 | -0.9 | 0.9 | -1.0 | 0.9 | -0.8 | 1.1 | 1.0 | -1.0 | 0.9 | -1.1 | 0.9 | -1.1 |
Seeking ratio, punishment vs. effort | 0.9 | 1.2 | 1.6 | -1.0 | 1.0 | 1.1 | -1.1 | -0.8 | 1.2 | -1.1 | 1.0 | -1.2 | 1.3 | 1.2 | -0.8 | 1.0 | -1.0 | 1.0 | -1.2 | -1.2 | 1.1 | -1.2 | 1.2 | -1.1 | 1.0 |
Run reversals in cocaine runway, males | 0.9 | 0.9 | 2.0 | -1.0 | 0.6 | 1.1 | -1.2 | -1.1 | 0.8 | -0.7 | 1.0 | -1.0 | 1.4 | 1.2 | -0.4 | 0.3 | -1.1 | 0.4 | -0.9 | -0.7 | 1.1 | -1.3 | 0.7 | -0.4 | 1.3 |
Sr content in liver | 0.9 | 0.8 | 1.6 | 0.7 | -1.0 | -0.7 | 0.9 | 0.6 | -0.8 | 1.3 | -0.9 | 0.9 | -1.1 | -0.7 | 1.1 | -0.9 | 0.8 | -0.6 | 0.9 | 1.0 | -1.0 | 0.8 | -0.9 | 0.9 | -1.0 |
Water consumed over 24 hours | 0.8 | 0.9 | 2.1 | -1.1 | 1.0 | 0.9 | -1.0 | -0.6 | 0.9 | -1.0 | 1.0 | -0.9 | 1.4 | 0.9 | -0.9 | 1.0 | -0.7 | 0.5 | -1.1 | -0.8 | 1.0 | -1.0 | 0.7 | -0.6 | 1.1 |
Delay discounting water rate 6 sec | 0.8 | 1.2 | 2.2 | 1.2 | -1.1 | -1.0 | 0.8 | 1.0 | -1.2 | 1.0 | -1.0 | 1.1 | -0.6 | -0.8 | 1.2 | -1.2 | 1.1 | -1.5 | 1.1 | 1.3 | -1.0 | 0.9 | -1.3 | 1.3 | -0.8 |
Reaction time number correct | 0.8 | 1.2 | 2.7 | 1.2 | -1.0 | -0.9 | 0.8 | 0.8 | -1.3 | 1.2 | -1.1 | 0.9 | -0.8 | -0.7 | 1.5 | -1.6 | 0.8 | -1.2 | 1.2 | 1.2 | -1.1 | 0.6 | -1.1 | 1.3 | -0.9 |
Reaction time mean minus median AUC | 0.8 | 1.0 | 2.3 | -1.0 | 1.0 | 1.0 | -1.0 | -1.2 | 1.3 | -0.9 | 0.9 | -0.9 | 0.1 | 1.2 | -0.9 | 0.9 | -1.1 | 1.5 | -0.8 | -0.8 | 1.1 | -0.8 | 0.9 | -1.3 | 0.8 |
Reaction time trials correct on left | 0.8 | 1.2 | 2.7 | 1.2 | -1.0 | -0.9 | 0.8 | 0.8 | -1.3 | 1.2 | -1.1 | 0.9 | -0.8 | -0.7 | 1.5 | -1.6 | 0.8 | -1.2 | 1.2 | 1.2 | -1.1 | 0.6 | -1.1 | 1.3 | -0.9 |
Conditioned locomotion | 0.8 | 0.9 | 1.6 | -0.7 | 0.7 | 1.1 | -1.2 | -1.2 | 1.0 | -0.8 | 0.9 | -0.9 | 0.4 | 1.1 | -1.0 | 1.0 | -0.9 | 1.2 | -0.8 | -0.8 | 1.1 | -1.1 | 0.8 | -1.3 | 0.8 |
Locomotion distance, session 3 | 0.8 | 0.9 | 1.8 | 1.0 | -0.9 | -0.6 | 0.6 | 0.6 | -1.1 | 1.3 | -0.9 | 0.8 | -0.4 | -0.6 | 1.1 | -1.4 | 0.7 | -1.2 | 0.9 | 1.1 | -0.9 | 0.3 | -1.0 | 1.3 | -0.7 |
Total locomotion distance, hab. session 2 | 0.8 | 1.1 | 1.7 | 1.2 | -1.3 | -1.0 | 0.9 | 1.3 | -1.0 | 0.9 | -1.0 | 1.1 | -0.5 | -1.2 | 0.5 | -0.9 | 1.3 | -1.3 | 0.9 | 1.2 | -0.9 | 0.9 | -1.0 | 1.1 | -0.9 |
Change in fecal boli incidents, locomotor task | 0.8 | 0.8 | 2.4 | -0.7 | 0.8 | 1.0 | -1.1 | -0.6 | 0.5 | -0.8 | 0.8 | -1.1 | 1.6 | 1.1 | -0.3 | 0.3 | -0.9 | 0.2 | -1.0 | -0.8 | 0.8 | -1.4 | 0.9 | -0.4 | 1.1 |
K content in liver | 0.8 | 0.8 | 1.5 | 0.9 | -0.9 | -1.1 | 1.0 | 1.2 | -1.0 | 0.7 | -0.9 | 0.9 | -0.3 | -1.1 | 0.4 | -0.8 | 1.1 | -1.2 | 0.7 | 0.8 | -0.9 | 1.0 | -0.9 | 1.1 | -0.8 |
Tibialis anterior weight | 0.7 | 2.6 | 3.3 | 1.4 | -1.6 | -1.7 | 1.8 | 1.7 | -1.5 | 1.6 | -1.6 | 1.6 | -1.4 | -1.6 | 1.7 | -1.5 | 1.6 | -1.4 | 1.5 | 1.5 | -1.8 | 1.8 | -1.5 | 1.7 | -1.7 |
Delay discounting total patch changes 0 sec | 0.7 | 1.2 | 1.9 | 1.2 | -1.2 | -1.3 | 1.2 | 1.4 | -1.1 | 0.7 | -1.1 | 1.1 | -0.8 | -1.3 | 0.6 | -0.9 | 1.2 | -1.1 | 1.0 | 1.0 | -1.0 | 1.3 | -0.7 | 1.0 | -1.1 |
Reaction time trials AUC | 0.7 | 0.9 | 2.3 | 1.1 | -0.8 | -0.8 | 0.7 | 0.7 | -1.2 | 1.1 | -1.0 | 0.8 | -0.7 | -0.6 | 1.3 | -1.5 | 0.7 | -1.1 | 1.0 | 1.0 | -1.0 | 0.5 | -1.0 | 1.2 | -0.8 |
Lifetime Intake | 0.7 | 0.8 | 1.7 | -0.7 | 0.7 | 0.8 | -0.6 | -0.4 | 0.9 | -1.0 | 0.9 | -1.0 | 1.1 | 0.7 | -0.9 | 1.0 | -0.8 | 0.9 | -1.1 | -1.2 | 0.9 | -0.8 | 1.3 | -0.9 | 0.8 |
Short access day 10 total infusions | 0.7 | 0.8 | 1.5 | -1.0 | 1.2 | 0.7 | -0.6 | -0.6 | 0.9 | -0.9 | 0.8 | -0.9 | 0.7 | 0.6 | -1.0 | 0.9 | -0.9 | 1.0 | -0.9 | -1.2 | 0.8 | -0.7 | 1.1 | -0.9 | 0.7 |
Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.9 | 2.1 | 0.7 | -0.7 | -0.9 | 1.2 | 1.0 | -0.8 | 1.1 | -0.9 | 1.0 | -0.6 | -1.2 | 1.4 | -0.6 | 1.0 | -0.9 | 0.7 | 0.7 | -0.8 | 0.9 | -0.8 | 0.9 | -1.0 |
Bone: cortical apparent density | 0.7 | 0.9 | 1.4 | 0.8 | -1.0 | -0.9 | 0.9 | 1.0 | -1.0 | 1.0 | -0.9 | 0.9 | -0.3 | -0.9 | 1.1 | -1.0 | 0.9 | -1.2 | 0.8 | 0.9 | -1.0 | 0.7 | -0.8 | 1.1 | -0.8 |
Bone: minimum diameter | 0.7 | 1.3 | 2.3 | -0.7 | 1.0 | 1.2 | -1.5 | -1.2 | 1.2 | -1.5 | 1.1 | -1.2 | 0.9 | 1.2 | -0.8 | 1.0 | -1.1 | 1.0 | -1.0 | -1.1 | 1.5 | -1.2 | 1.0 | -1.4 | 1.2 |
Delta ambulatory time before/after self-admin | 0.7 | 0.7 | 3.4 | -0.6 | 0.3 | 0.6 | -1.2 | -0.0 | 0.7 | -1.4 | 0.8 | -0.8 | 1.8 | 0.8 | -0.5 | 0.6 | -0.2 | -0.2 | -1.0 | -0.4 | 1.0 | -1.0 | 0.5 | -0.3 | 1.1 |
Time to tail flick, vehicle, after self-admin | 0.7 | 0.8 | 1.8 | 0.4 | -1.0 | -0.6 | 0.4 | 0.5 | -0.9 | 0.8 | -0.8 | 0.8 | -1.0 | -0.4 | 1.2 | -1.3 | 0.8 | -0.9 | 1.1 | 1.2 | -0.7 | 0.6 | -1.3 | 0.9 | -0.7 |
Delay disc. indifference point, 8s delay | 0.7 | 0.7 | 1.6 | 0.8 | -0.7 | -0.7 | 1.0 | 0.7 | -0.9 | 1.3 | -0.9 | 0.8 | -0.6 | -0.9 | 1.2 | -0.7 | 0.8 | -0.9 | 0.8 | 0.9 | -1.0 | 0.6 | -0.7 | 1.0 | -0.9 |
Se content in liver | 0.7 | 0.8 | 1.2 | 0.8 | -1.0 | -0.8 | 0.7 | 0.7 | -1.0 | 1.0 | -0.9 | 1.0 | -0.8 | -0.7 | 0.9 | -1.1 | 0.8 | -1.0 | 1.0 | 0.9 | -0.8 | 0.8 | -1.1 | 1.0 | -0.8 |
Times rat made contact with spout | 0.6 | 0.7 | 1.7 | -1.0 | 1.0 | 0.8 | -0.8 | -0.5 | 0.9 | -0.8 | 0.9 | -0.8 | 1.3 | 0.8 | -0.9 | 1.0 | -0.7 | 0.6 | -1.1 | -0.9 | 0.8 | -0.9 | 0.8 | -0.6 | 0.9 |
Mean time between licks in bursts | 0.6 | 0.8 | 1.3 | 1.1 | -0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.9 | -1.0 | 0.9 | -1.2 | -0.8 | 1.0 | -0.8 | 0.9 | -0.5 | 1.0 | 0.8 | -1.0 | 1.0 | -0.8 | 0.7 | -1.1 |
Indifference point 0 sec | 0.6 | 0.9 | 1.7 | 1.0 | -1.1 | -1.2 | 1.0 | 1.3 | -0.9 | 0.5 | -0.9 | 1.0 | -0.7 | -1.2 | 0.5 | -0.7 | 1.2 | -1.0 | 0.8 | 0.9 | -0.8 | 1.2 | -0.5 | 0.9 | -0.9 |
Reaction time premature initiations | 0.6 | 0.8 | 1.7 | 0.8 | -0.7 | -1.1 | 0.9 | 1.2 | -1.0 | 0.5 | -0.9 | 0.8 | -0.3 | -1.1 | 1.0 | -1.0 | 1.0 | -1.3 | 0.8 | 0.8 | -0.9 | 0.9 | -0.9 | 1.1 | -0.7 |
Conditioned reinforcement - actives | 0.6 | 0.6 | 1.8 | -0.8 | 0.1 | 1.0 | -0.9 | -0.6 | 0.7 | -0.5 | 0.7 | -0.8 | 1.3 | 0.8 | -0.6 | 0.6 | -0.6 | 0.3 | -0.9 | -0.6 | 0.9 | -1.1 | 0.8 | -0.5 | 0.9 |
Cocaine induced anxiety | 0.6 | 0.7 | 2.2 | -1.2 | 1.5 | 0.5 | -0.4 | -0.7 | 0.7 | -0.9 | 0.8 | -0.9 | 0.5 | 0.4 | -0.6 | 0.6 | -1.0 | 1.0 | -0.7 | -1.2 | 0.5 | -0.4 | 0.9 | -0.7 | 0.7 |
Incentive salience index mean | 0.6 | 0.7 | 1.3 | 0.9 | -0.8 | -0.9 | 1.0 | 1.0 | -0.8 | 0.9 | -0.8 | 0.9 | -0.4 | -1.2 | 0.9 | -0.6 | 1.0 | -1.0 | 0.7 | 0.7 | -0.7 | 0.8 | -0.7 | 0.8 | -0.8 |
Time in novel zone, hab. session 1 | 0.6 | 0.5 | 1.4 | -0.8 | 0.6 | 0.5 | -0.8 | -0.7 | 0.9 | -1.0 | 0.7 | -0.5 | -0.2 | 0.8 | -1.2 | 0.7 | -0.6 | 1.1 | -0.5 | -0.5 | 0.9 | -0.2 | 0.4 | -1.1 | 0.5 |
Pavlov. Cond. magazine entry number | 0.6 | 0.8 | 1.8 | -0.8 | 0.6 | 0.9 | -1.1 | -0.9 | 0.8 | -1.1 | 0.9 | -1.0 | 0.5 | 1.0 | -1.4 | 0.6 | -0.9 | 0.8 | -0.7 | -0.7 | 0.9 | -0.8 | 0.8 | -1.0 | 0.9 |
Bone: cortical tissue density | 0.6 | 0.8 | 1.3 | 0.8 | -1.0 | -0.8 | 0.9 | 1.0 | -0.9 | 1.0 | -0.9 | 0.8 | -0.3 | -0.9 | 1.1 | -1.0 | 0.9 | -1.1 | 0.7 | 0.9 | -0.9 | 0.7 | -0.8 | 1.1 | -0.8 |
Delta distance traveled before/after self-admin | 0.6 | 0.6 | 2.5 | -0.7 | 0.3 | 0.6 | -1.2 | -0.1 | 0.6 | -1.2 | 0.7 | -0.8 | 1.6 | 0.8 | -0.6 | 0.5 | -0.3 | -0.1 | -0.9 | -0.4 | 0.9 | -1.0 | 0.4 | -0.4 | 1.0 |
Distance moved, locomotor task time 1 | 0.6 | 0.7 | 1.1 | -0.3 | 0.4 | 0.9 | -1.0 | -1.0 | 0.8 | -0.9 | 0.8 | -0.8 | 0.4 | 1.0 | -1.0 | 0.9 | -0.8 | 0.9 | -0.7 | -0.5 | 1.0 | -0.8 | 0.5 | -1.1 | 0.9 |
Glucose | 0.5 | 0.7 | 1.5 | 0.9 | -0.9 | -1.0 | 1.0 | 0.9 | -0.7 | 0.7 | -0.9 | 0.9 | -1.2 | -1.0 | 0.5 | -0.6 | 0.9 | -0.5 | 0.9 | 0.7 | -0.8 | 1.1 | -0.8 | 0.4 | -1.0 |
Number of licking bursts | 0.5 | 0.5 | 1.1 | 0.8 | -0.8 | -0.6 | 0.6 | 0.9 | -0.7 | 0.7 | -0.7 | 0.8 | -0.1 | -0.7 | 0.8 | -0.8 | 0.8 | -1.1 | 0.6 | 0.8 | -0.7 | 0.5 | -0.7 | 1.0 | -0.6 |
Condit. Reinf. active responses | 0.5 | 0.7 | 2.7 | -0.6 | 0.5 | 0.7 | -0.8 | -0.4 | 0.6 | -0.8 | 0.8 | -0.8 | 1.7 | 0.6 | -1.1 | 0.9 | -0.5 | 0.1 | -1.0 | -0.7 | 0.8 | -0.9 | 0.7 | -0.4 | 1.0 |
Intermittent access intake escalation | 0.5 | 0.5 | 1.0 | 0.6 | -1.0 | -0.7 | 0.7 | 0.6 | -0.8 | 0.8 | -0.7 | 0.7 | -0.5 | -0.7 | 0.7 | -0.5 | 0.7 | -0.7 | 0.7 | 0.7 | -1.0 | 0.7 | -0.6 | 0.7 | -0.7 |
Intermittent access standard deviation | 0.5 | 0.5 | 1.1 | -0.5 | 0.4 | 0.6 | -0.5 | -0.6 | 0.7 | -0.8 | 0.7 | -0.8 | 0.5 | 0.6 | -0.9 | 0.9 | -0.8 | 1.0 | -0.7 | -0.9 | 0.6 | -0.5 | 1.0 | -1.0 | 0.5 |
Short access day 10 total inactive lever presses | 0.5 | 0.5 | 1.3 | -0.4 | 0.3 | 0.7 | -0.8 | -0.5 | 0.8 | -1.0 | 0.7 | -0.7 | 0.8 | 0.9 | -1.1 | 0.6 | -0.6 | 0.6 | -0.8 | -0.7 | 0.8 | -0.7 | 0.7 | -0.8 | 0.8 |
Pavlov. Cond. index score | 0.5 | 0.6 | 1.5 | 0.5 | -0.6 | -0.8 | 1.1 | 1.0 | -0.6 | 0.9 | -0.8 | 0.9 | -0.4 | -1.1 | 1.2 | -0.4 | 0.9 | -0.7 | 0.6 | 0.6 | -0.7 | 0.9 | -0.6 | 0.8 | -0.9 |
Pavlov. Cond. latency score | 0.5 | 0.6 | 1.3 | 0.5 | -0.6 | -0.8 | 1.0 | 0.9 | -0.6 | 0.9 | -0.7 | 0.9 | -0.5 | -1.0 | 1.1 | -0.3 | 0.8 | -0.7 | 0.6 | 0.6 | -0.6 | 0.9 | -0.6 | 0.7 | -0.8 |
Bone: cortical porosity | 0.5 | 0.5 | 1.4 | -0.6 | 0.6 | 0.6 | -0.8 | -0.8 | 0.9 | -0.9 | 0.7 | -0.6 | 0.0 | 0.6 | -0.6 | 0.8 | -0.6 | 1.0 | -0.6 | -0.7 | 1.0 | -0.5 | 0.5 | -1.2 | 0.6 |
Ambulatory time after self-admin | 0.5 | 0.6 | 2.0 | 0.8 | -1.1 | -0.8 | 0.6 | 1.4 | -0.6 | 0.2 | -0.7 | 0.6 | 0.3 | -0.8 | 0.7 | -0.6 | 1.1 | -1.2 | 0.4 | 0.8 | -0.5 | 0.6 | -0.6 | 0.9 | -0.5 |
Locomotion in novel chamber | 0.5 | 0.6 | 4.1 | 1.1 | -2.0 | -0.3 | 0.0 | 0.5 | -0.5 | 0.4 | -0.7 | 0.5 | -0.9 | 0.0 | 0.5 | -0.8 | 0.8 | -0.4 | 0.8 | 1.2 | -0.3 | 0.3 | -0.7 | 0.1 | -0.7 |
Run reversals in cocaine runway, females | 0.5 | 0.5 | 1.4 | 1.0 | -1.2 | -0.4 | 0.3 | 0.5 | -0.6 | 0.7 | -0.7 | 0.6 | -0.6 | -0.4 | 0.8 | -0.8 | 0.8 | -0.7 | 0.7 | 0.9 | -0.5 | 0.3 | -0.9 | 0.5 | -0.6 |
Length with tail | 0.4 | 1.3 | 2.1 | -0.8 | 1.4 | 1.1 | -1.3 | -1.1 | 1.0 | -1.4 | 1.2 | -1.3 | 1.3 | 1.2 | -1.1 | 0.8 | -1.2 | 0.8 | -1.2 | -1.2 | 1.1 | -1.3 | 1.0 | -0.9 | 1.3 |
Intraocular pressure | 0.4 | 0.6 | 1.1 | -0.8 | 0.6 | 1.0 | -0.8 | -1.0 | 0.7 | -0.5 | 0.8 | -0.9 | 0.8 | 0.9 | -0.5 | 0.5 | -0.9 | 0.6 | -0.7 | -0.8 | 0.8 | -1.0 | 0.8 | -0.6 | 0.9 |
Delay discounting total patch changes 6 sec | 0.4 | 0.6 | 1.6 | 0.9 | -1.0 | -0.9 | 0.7 | 1.3 | -0.6 | 0.3 | -0.6 | 0.8 | 0.3 | -1.0 | 0.2 | -0.4 | 1.1 | -1.2 | 0.4 | 0.8 | -0.4 | 0.8 | -0.5 | 1.0 | -0.5 |
Delay discounting water rate 12 sec | 0.4 | 0.6 | 1.1 | 0.8 | -0.8 | -0.8 | 0.6 | 0.9 | -0.7 | 0.5 | -0.7 | 0.7 | -0.6 | -0.5 | 0.8 | -1.0 | 0.7 | -0.8 | 0.8 | 0.8 | -0.7 | 0.8 | -0.7 | 0.9 | -0.6 |
Median of all reaction times | 0.4 | 0.5 | 0.9 | 0.9 | -0.5 | -0.8 | 0.8 | 0.7 | -0.6 | 0.6 | -0.7 | 0.7 | -0.9 | -0.6 | 0.9 | -0.8 | 0.5 | -0.4 | 0.8 | 0.6 | -0.7 | 0.9 | -0.5 | 0.5 | -0.8 |
Reaction time premature initiation rate | 0.4 | 0.5 | 1.2 | 0.5 | -0.6 | -1.0 | 0.7 | 1.1 | -0.6 | 0.1 | -0.6 | 0.6 | -0.1 | -1.1 | 0.6 | -0.5 | 1.0 | -1.1 | 0.5 | 0.5 | -0.5 | 0.9 | -0.6 | 0.7 | -0.5 |
Std. dev. reaction times | 0.4 | 0.5 | 1.1 | -0.4 | 0.5 | 0.8 | -0.8 | -0.7 | 1.0 | -0.8 | 0.7 | -0.6 | 0.2 | 1.0 | -0.6 | 0.7 | -0.6 | 1.0 | -0.6 | -0.5 | 0.9 | -0.5 | 0.7 | -1.0 | 0.6 |
Condit. Reinf. lever presses | 0.4 | 0.5 | 1.2 | 0.6 | -0.7 | -0.8 | 0.7 | 0.9 | -0.8 | 0.6 | -0.6 | 0.7 | -0.0 | -1.0 | -0.1 | -0.4 | 0.8 | -1.1 | 0.5 | 0.6 | -0.7 | 0.7 | -0.7 | 0.8 | -0.5 |
Intermittent access intake day 1-15 change | 0.4 | 0.4 | 0.9 | 0.4 | -0.9 | -0.6 | 0.7 | 0.6 | -0.8 | 0.7 | -0.6 | 0.6 | -0.4 | -0.7 | 0.6 | -0.4 | 0.6 | -0.7 | 0.6 | 0.6 | -0.9 | 0.5 | -0.5 | 0.7 | -0.6 |
Intermitt. access day 15 inactive lever presses | 0.4 | 0.4 | 1.5 | -0.4 | 0.4 | 0.5 | -0.2 | -0.1 | 0.7 | -0.5 | 0.6 | -0.5 | 1.2 | 0.3 | -1.2 | 1.1 | -0.4 | 0.4 | -0.9 | -0.7 | 0.4 | -0.3 | 0.9 | -0.4 | 0.6 |
Intermittent access day 1 locomotion | 0.4 | 0.4 | 0.8 | -0.6 | 0.3 | 0.5 | -0.4 | -0.2 | 0.6 | -0.7 | 0.5 | -0.7 | 0.6 | 0.5 | -0.9 | 0.8 | -0.5 | 0.7 | -0.7 | -0.7 | 0.6 | -0.5 | 0.9 | -0.7 | 0.5 |
Intermittent access total locomotion | 0.4 | 0.5 | 0.9 | -0.8 | 0.7 | 0.6 | -0.4 | -0.3 | 0.6 | -0.8 | 0.6 | -0.8 | 0.8 | 0.5 | -0.7 | 0.6 | -0.7 | 0.7 | -0.7 | -0.9 | 0.6 | -0.6 | 1.0 | -0.6 | 0.6 |
Progressive ratio test 1 active lever presses | 0.4 | 0.4 | 0.9 | -0.6 | 0.7 | 0.6 | -0.3 | -0.5 | 0.6 | -0.5 | 0.6 | -0.7 | 0.9 | 0.5 | -0.7 | 0.8 | -0.7 | 0.6 | -0.8 | -0.9 | 0.4 | -0.6 | 1.0 | -0.5 | 0.6 |
Progressive ratio test 2 inactive lever presses | 0.4 | 0.5 | 1.2 | 0.8 | -1.1 | -0.7 | 1.1 | 0.8 | -0.6 | 0.9 | -0.6 | 0.7 | -0.1 | -0.9 | 0.3 | -0.2 | 0.5 | -0.6 | 0.5 | 0.5 | -0.9 | 0.8 | -0.2 | 0.8 | -0.6 |
Time in closed arm after self-admin | 0.4 | 0.5 | 1.2 | -0.4 | 0.6 | 0.6 | -0.6 | -0.6 | 0.9 | -0.6 | 0.6 | -0.4 | 0.1 | 0.5 | -1.1 | 1.1 | -0.4 | 1.0 | -0.6 | -0.6 | 0.7 | -0.4 | 0.5 | -1.1 | 0.4 |
Fecal boli incidents, locomotor time 1 | 0.4 | 0.4 | 0.7 | 0.4 | -0.5 | -0.7 | 0.7 | 0.7 | -0.6 | 0.7 | -0.6 | 0.7 | -0.4 | -0.7 | 0.5 | -0.6 | 0.8 | -0.8 | 0.6 | 0.7 | -0.7 | 0.6 | -0.7 | 0.8 | -0.6 |
Vertical activity count, locomotor time 2 | 0.4 | 0.5 | 0.9 | -0.4 | 0.3 | 0.7 | -0.8 | -0.8 | 0.7 | -0.8 | 0.7 | -0.7 | 0.3 | 0.9 | -0.6 | 0.9 | -0.6 | 0.8 | -0.6 | -0.5 | 0.7 | -0.6 | 0.5 | -0.9 | 0.6 |
Delay discounting total patch changes 24 sec | 0.3 | 0.4 | 1.1 | 0.6 | -1.0 | -0.6 | 0.6 | 0.6 | -0.7 | 0.6 | -0.6 | 0.6 | -0.2 | -0.7 | 0.7 | -0.6 | 0.6 | -0.8 | 0.5 | 0.6 | -0.6 | 0.5 | -0.3 | 0.8 | -0.5 |
Intermittent access total infusions | 0.3 | 0.3 | 0.6 | -0.5 | 0.4 | 0.5 | -0.4 | -0.3 | 0.5 | -0.6 | 0.5 | -0.7 | 0.7 | 0.5 | -0.4 | 0.5 | -0.5 | 0.5 | -0.6 | -0.7 | 0.5 | -0.5 | 0.8 | -0.5 | 0.5 |
Incentive Sensitization - Responses | 0.3 | 0.3 | 0.7 | 0.5 | -0.6 | -0.5 | 0.7 | 0.6 | -0.4 | 0.6 | -0.5 | 0.5 | 0.1 | -0.7 | 0.6 | -0.4 | 0.5 | -0.7 | 0.3 | 0.4 | -0.4 | 0.5 | -0.4 | 0.8 | -0.4 |
Progressive ratio test 1 breakpoint | 0.3 | 0.3 | 0.6 | -0.5 | 0.7 | 0.6 | -0.3 | -0.5 | 0.4 | -0.3 | 0.5 | -0.6 | 0.7 | 0.4 | -0.5 | 0.6 | -0.7 | 0.5 | -0.6 | -0.8 | 0.3 | -0.6 | 0.8 | -0.4 | 0.5 |
One hour access (0.3 mA shock) | 0.3 | 0.3 | 1.2 | 0.6 | -1.1 | -0.4 | 0.7 | 0.4 | -0.5 | 0.8 | -0.6 | 0.5 | -0.5 | -0.4 | 0.9 | -0.6 | 0.4 | -0.4 | 0.5 | 0.4 | -0.5 | 0.4 | -0.3 | 0.5 | -0.6 |
Locomotion velocity, session 2 | 0.3 | 0.3 | 0.8 | -0.6 | 0.4 | 0.5 | -0.7 | -0.4 | 0.6 | -0.7 | 0.5 | -0.4 | 0.6 | 0.5 | -0.4 | 0.6 | -0.3 | 0.2 | -0.6 | -0.3 | 0.9 | -0.6 | 0.3 | -0.6 | 0.6 |
Locomotion velocity, session 3 | 0.3 | 0.4 | 0.8 | -0.7 | 0.5 | 0.8 | -0.9 | -0.8 | 0.5 | -0.4 | 0.6 | -0.5 | 0.6 | 0.6 | -0.3 | 0.3 | -0.6 | 0.3 | -0.5 | -0.4 | 0.9 | -0.9 | 0.3 | -0.5 | 0.7 |
Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 | 0.6 | -0.5 | 0.7 | 0.4 | -0.4 | 0.5 | -0.5 | 0.2 | -0.6 | -0.6 | 0.7 | -0.6 | 0.5 | -0.4 | 0.7 |
Bone: apparent density | 0.3 | 0.5 | 0.8 | 0.3 | -0.6 | -0.9 | 0.8 | 0.9 | -0.8 | 0.6 | -0.8 | 0.7 | -0.7 | -0.7 | 0.7 | -0.9 | 0.7 | -0.7 | 0.8 | 0.7 | -0.8 | 0.8 | -0.7 | 0.7 | -0.8 |
Delta time in open arm before/after self-admin | 0.3 | 0.3 | 0.8 | 0.2 | -0.8 | -0.4 | 0.3 | 0.3 | -0.4 | 0.4 | -0.5 | 0.3 | -0.9 | -0.3 | 0.7 | -0.8 | 0.4 | -0.3 | 0.7 | 0.7 | -0.3 | 0.5 | -0.6 | 0.3 | -0.5 |
Diff in mean of infusions in LGA sessions | 0.3 | 0.4 | 0.9 | 0.3 | -0.1 | -0.7 | 0.7 | 0.8 | -0.7 | 0.8 | -0.6 | 0.7 | -0.1 | -0.7 | 0.5 | -0.5 | 0.5 | -0.9 | 0.4 | 0.4 | -0.7 | 0.4 | -0.5 | 1.0 | -0.6 |
Bouts of movement, locomotor time 1 | 0.3 | 0.4 | 1.4 | -1.0 | 1.2 | 0.6 | -0.4 | -0.8 | 0.4 | -0.2 | 0.6 | -0.6 | 0.5 | 0.5 | 0.0 | 0.2 | -0.9 | 0.5 | -0.5 | -0.8 | 0.3 | -0.7 | 0.6 | -0.2 | 0.6 |
Rest time, locomotor task time 1 | 0.3 | 0.3 | 1.2 | -1.0 | 1.1 | 0.3 | -0.0 | -0.3 | 0.6 | -0.2 | 0.4 | -0.5 | 0.2 | 0.2 | -0.4 | 0.7 | -0.5 | 0.7 | -0.5 | -0.8 | 0.3 | -0.3 | 0.7 | -0.5 | 0.2 |
Latency to leave start box in cocaine runway, F | 0.3 | 0.3 | 0.6 | 0.3 | -0.4 | -0.5 | 0.5 | 0.3 | -0.5 | 0.6 | -0.5 | 0.6 | -0.8 | -0.5 | 0.8 | -0.5 | 0.5 | -0.4 | 0.6 | 0.6 | -0.6 | 0.6 | -0.7 | 0.5 | -0.5 |
Co content in liver | 0.3 | 0.3 | 0.7 | -0.6 | 0.5 | 0.5 | -0.5 | -0.3 | 0.8 | -0.7 | 0.6 | -0.5 | 0.5 | 0.5 | -0.7 | 0.8 | -0.4 | 0.7 | -0.7 | -0.6 | 0.7 | -0.4 | 0.5 | -0.6 | 0.5 |
Mn content in liver | 0.3 | 0.3 | 0.9 | -0.4 | 0.2 | 0.7 | -0.7 | -0.6 | 0.5 | -0.3 | 0.5 | -0.4 | 0.6 | 0.6 | -0.9 | 0.5 | -0.4 | 0.4 | -0.5 | -0.3 | 0.7 | -0.7 | 0.4 | -0.5 | 0.5 |
Tail length | 0.2 | 0.5 | 1.1 | 1.1 | -0.8 | -0.6 | 0.5 | 0.4 | -0.7 | 0.6 | -0.7 | 0.6 | -1.0 | -0.3 | 0.8 | -0.9 | 0.5 | -0.5 | 0.8 | 0.8 | -0.7 | 0.6 | -0.9 | 0.6 | -0.6 |
Extensor digitorum longus weight | 0.2 | 0.8 | 1.5 | 1.0 | -1.1 | -0.9 | 0.7 | 0.7 | -0.7 | 0.7 | -0.8 | 1.0 | -1.2 | -0.8 | 0.8 | -0.6 | 1.0 | -0.6 | 1.0 | 1.0 | -0.8 | 1.1 | -1.0 | 0.6 | -0.9 |
Soleus weight | 0.2 | 0.5 | 1.2 | 0.9 | -0.8 | -0.6 | 0.6 | 1.0 | -0.5 | 0.6 | -0.5 | 0.7 | 0.4 | -0.8 | -0.2 | -0.4 | 0.9 | -1.1 | 0.3 | 0.7 | -0.6 | 0.5 | -0.6 | 0.9 | -0.4 |
Indifference point AUC | 0.2 | 0.2 | 1.0 | 0.2 | -0.4 | -0.2 | 0.2 | 0.4 | -0.5 | 0.5 | -0.2 | 0.3 | 0.8 | -0.3 | 0.5 | -0.4 | 0.2 | -1.0 | 0.0 | 0.4 | -0.3 | -0.1 | -0.2 | 0.9 | 0.1 |
Delay discounting total patch changes 18 sec | 0.2 | 0.3 | 0.7 | 0.6 | -0.9 | -0.6 | 0.6 | 0.8 | -0.5 | 0.2 | -0.4 | 0.3 | 0.2 | -0.7 | 0.0 | -0.2 | 0.6 | -0.7 | 0.3 | 0.4 | -0.5 | 0.5 | -0.1 | 0.6 | -0.4 |
Delay discounting water rate 0 sec | 0.2 | 0.3 | 0.7 | 0.7 | -0.5 | -0.7 | 0.5 | 0.9 | -0.5 | 0.2 | -0.4 | 0.7 | 0.1 | -0.5 | -0.1 | -0.4 | 0.6 | -0.8 | 0.3 | 0.5 | -0.4 | 0.7 | -0.5 | 0.8 | -0.3 |
Reaction time mean minus median | 0.2 | 0.2 | 0.6 | -0.2 | 0.3 | 0.5 | -0.6 | -0.6 | 0.8 | -0.5 | 0.4 | -0.3 | -0.2 | 0.7 | -0.4 | 0.5 | -0.3 | 0.8 | -0.3 | -0.2 | 0.7 | -0.3 | 0.3 | -0.7 | 0.3 |
Reaction time omissions | 0.2 | 0.3 | 0.9 | 0.9 | -0.9 | -0.3 | 0.3 | 0.3 | -0.4 | 0.6 | -0.5 | 0.5 | -0.6 | -0.3 | 0.4 | -0.6 | 0.4 | -0.4 | 0.6 | 0.7 | -0.5 | 0.4 | -0.6 | 0.5 | -0.5 |
Reaction time false alarm rate | 0.2 | 0.2 | 0.7 | 0.1 | -0.3 | 0.5 | -0.6 | -0.6 | 0.7 | -0.5 | 0.4 | -0.2 | -0.1 | 0.4 | -0.5 | 0.6 | -0.3 | 0.7 | -0.3 | -0.2 | 0.7 | -0.2 | 0.2 | -0.8 | 0.3 |
Condit. Reinf. lever reinforcers received | 0.2 | 0.3 | 1.7 | -0.3 | 0.3 | 0.4 | -0.4 | -0.1 | 0.3 | -0.5 | 0.5 | -0.5 | 1.3 | 0.2 | -0.8 | 0.6 | -0.2 | -0.2 | -0.7 | -0.4 | 0.5 | -0.6 | 0.5 | -0.2 | 0.7 |
Intermittent access intake escalation 2 | 0.2 | 0.2 | 0.6 | 0.5 | -0.7 | -0.4 | 0.4 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | -0.5 | -0.4 | 0.4 | -0.2 | 0.4 | -0.3 | 0.4 | 0.5 | -0.5 | 0.4 | -0.4 | 0.3 | -0.4 |
Intermitt. access day 1 inactive lever presses | 0.2 | 0.2 | 1.2 | 0.0 | 0.2 | 0.1 | -0.1 | 0.2 | 0.5 | -0.7 | 0.3 | -0.3 | 0.5 | 0.1 | -1.1 | 0.7 | -0.1 | 0.3 | -0.5 | -0.5 | 0.3 | 0.1 | 0.5 | -0.4 | 0.3 |
Progressive ratio test 1 inactive lever presses | 0.2 | 0.2 | 0.9 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | 0.6 | -0.4 | 0.4 | -0.3 | 0.1 | 0.1 | -0.9 | 0.9 | -0.4 | 0.8 | -0.5 | -0.7 | 0.3 | 0.1 | 0.8 | -0.7 | 0.1 |
Short access day 1 locomotion | 0.2 | 0.2 | 0.5 | -0.0 | 0.3 | 0.3 | -0.1 | -0.1 | 0.5 | -0.4 | 0.3 | -0.3 | 0.2 | 0.1 | -0.7 | 0.7 | -0.2 | 0.6 | -0.4 | -0.6 | 0.4 | -0.1 | 0.6 | -0.6 | 0.1 |
One hour access (shock baseline) | 0.2 | 0.2 | 0.7 | -0.4 | 0.3 | 0.4 | -0.2 | -0.5 | 0.4 | -0.2 | 0.3 | -0.5 | -0.3 | 0.3 | -0.1 | 0.4 | -0.5 | 0.8 | -0.2 | -0.6 | 0.4 | -0.3 | 0.5 | -0.7 | 0.1 |
Locomotion velocity, session 1 | 0.2 | 0.2 | 1.3 | 0.3 | -0.1 | 0.3 | -0.6 | 0.0 | -0.1 | -0.3 | 0.2 | -0.2 | 1.1 | 0.2 | 0.1 | -0.1 | 0.0 | -0.7 | -0.3 | 0.1 | 0.3 | -0.7 | -0.0 | 0.3 | 0.5 |
Locomotion velocity, session 7 | 0.2 | 0.3 | 0.7 | -0.8 | 0.7 | 0.6 | -0.5 | -0.7 | 0.4 | -0.2 | 0.4 | -0.5 | 0.3 | 0.6 | 0.0 | 0.3 | -0.6 | 0.5 | -0.4 | -0.6 | 0.5 | -0.7 | 0.5 | -0.5 | 0.4 |
Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.5 | 0.4 | -0.3 | -0.5 | 0.6 | 0.7 | -0.5 | 0.5 | -0.4 | 0.5 | 0.0 | -0.7 | 0.6 | -0.3 | 0.6 | -0.7 | 0.3 | 0.3 | -0.3 | 0.4 | -0.3 | 0.5 | -0.4 |
Bone: cortical thickness | 0.2 | 0.3 | 0.8 | -0.4 | 0.5 | 0.4 | -0.2 | -0.1 | 0.6 | -0.5 | 0.5 | -0.5 | 0.9 | 0.4 | -0.6 | 0.7 | -0.4 | 0.5 | -0.7 | -0.7 | 0.4 | -0.4 | 0.9 | -0.3 | 0.4 |
Bone: post-yield work | 0.2 | 0.3 | 1.2 | -0.4 | 0.3 | 0.3 | -0.4 | 0.0 | 0.6 | -0.7 | 0.5 | -0.4 | 0.9 | 0.2 | -1.1 | 0.7 | -0.2 | 0.2 | -0.7 | -0.5 | 0.6 | -0.4 | 0.6 | -0.4 | 0.5 |
Bone: trabecular thickness | 0.2 | 0.2 | 0.9 | 0.4 | -0.6 | -0.5 | 0.5 | 0.2 | -0.4 | 0.4 | -0.5 | 0.5 | -1.0 | -0.4 | 0.3 | -0.4 | 0.4 | -0.1 | 0.6 | 0.5 | -0.4 | 0.7 | -0.5 | 0.2 | -0.6 |
Time in open arm before self-admin | 0.2 | 0.2 | 0.7 | -0.3 | 0.2 | 0.5 | -0.5 | -0.8 | 0.2 | -0.1 | 0.4 | -0.4 | 0.4 | 0.6 | -0.2 | -0.0 | -0.5 | 0.2 | -0.3 | -0.3 | 0.4 | -0.7 | 0.2 | -0.1 | 0.5 |
Time in open arm after self-admin | 0.2 | 0.3 | 0.9 | -0.1 | -0.7 | -0.3 | 0.2 | 0.0 | -0.6 | 0.5 | -0.5 | 0.2 | -0.9 | -0.1 | 0.8 | -1.0 | 0.2 | -0.3 | 0.7 | 0.6 | -0.3 | 0.3 | -0.5 | 0.4 | -0.4 |
Time to tail flick, test, before self-admin | 0.2 | 0.2 | 0.6 | 0.0 | 0.1 | 0.6 | -0.6 | -0.8 | 0.4 | -0.1 | 0.4 | -0.2 | 0.2 | 0.6 | -0.2 | 0.2 | -0.4 | 0.2 | -0.3 | -0.1 | 0.5 | -0.7 | 0.0 | -0.3 | 0.4 |
Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.6 | -0.2 | -0.4 | -0.5 | 0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 0.3 | -0.7 | -0.3 | 0.8 | -0.6 | 0.3 | -0.1 | 0.5 | 0.3 | -0.5 | 0.6 | -0.3 | 0.3 | -0.5 |
Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 1.0 | -0.1 | 0.3 | 0.1 | -0.1 | 0.3 | -0.4 | 0.3 | -0.1 | -0.2 | 1.0 | -0.0 | 0.6 | -0.7 | 0.1 | -0.9 | -0.1 | 0.1 | -0.1 | -0.6 | -0.1 | 0.8 | 0.2 |
Delay discount exponential model param | 0.2 | 0.2 | 0.6 | -0.5 | 0.3 | 0.2 | -0.5 | -0.4 | 0.4 | -0.8 | 0.4 | -0.4 | -0.1 | 0.5 | -0.7 | 0.2 | -0.4 | 0.6 | -0.3 | -0.4 | 0.5 | -0.2 | 0.3 | -0.6 | 0.4 |
Bouts of movement, locomotor time 2 | 0.2 | 0.2 | 0.8 | -0.9 | 0.6 | 0.4 | -0.1 | -0.2 | 0.5 | -0.3 | 0.4 | -0.5 | 0.3 | 0.4 | -0.5 | 0.5 | -0.5 | 0.7 | -0.5 | -0.7 | 0.2 | -0.3 | 0.7 | -0.5 | 0.3 |
Progressive ratio | 0.2 | 0.2 | 0.5 | 0.4 | -0.5 | -0.5 | 0.6 | 0.4 | -0.5 | 0.4 | -0.4 | 0.5 | -0.6 | -0.6 | 0.2 | -0.3 | 0.4 | -0.3 | 0.5 | 0.4 | -0.5 | 0.7 | -0.5 | 0.4 | -0.4 |
Latency to leave start box in cocaine runway | 0.2 | 0.3 | 0.6 | -0.8 | 0.8 | 0.4 | -0.4 | -0.8 | 0.4 | -0.3 | 0.5 | -0.5 | -0.0 | 0.4 | -0.5 | 0.6 | -0.6 | 0.7 | -0.3 | -0.5 | 0.3 | -0.3 | 0.4 | -0.6 | 0.4 |
Parametrial fat weight | 0.1 | 0.2 | 0.5 | -0.7 | 0.5 | 0.4 | -0.2 | -0.5 | 0.5 | -0.2 | 0.4 | -0.3 | 0.2 | 0.4 | -0.6 | 0.7 | -0.5 | 0.6 | -0.4 | -0.5 | 0.5 | -0.3 | 0.5 | -0.5 | 0.3 |
Delay discounting time to switch 0 sec | 0.1 | 0.1 | 1.1 | 0.0 | -0.1 | -0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.2 | 0.1 | -1.1 | -0.3 | 0.4 | -0.1 | 0.2 | 0.3 | 0.4 | 0.0 | -0.1 | 0.4 | -0.3 | -0.4 | -0.4 |
Light reinforcement 1 | 0.1 | 0.2 | 0.5 | 0.4 | -0.4 | 0.4 | -0.7 | -0.2 | 0.4 | -0.7 | 0.3 | -0.3 | 0.5 | 0.4 | -0.2 | 0.4 | -0.1 | 0.1 | -0.3 | -0.0 | 0.7 | -0.5 | 0.2 | -0.6 | 0.4 |
Reaction time num false alarms | 0.1 | 0.1 | 0.5 | 0.5 | -0.7 | 0.2 | -0.4 | -0.3 | 0.2 | -0.2 | 0.0 | 0.1 | -0.5 | 0.2 | 0.2 | -0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.4 | -0.1 | -0.2 | -0.4 | -0.0 |
Reaction time num false alarms AUC | 0.1 | 0.1 | 0.9 | 0.7 | -0.9 | 0.1 | -0.3 | -0.2 | 0.0 | -0.0 | -0.1 | 0.2 | -0.4 | 0.1 | 0.3 | -0.3 | 0.2 | -0.0 | 0.3 | 0.4 | 0.3 | -0.0 | -0.4 | -0.1 | -0.1 |
Reaction time mean | 0.1 | 0.2 | 0.7 | 0.7 | -0.3 | -0.5 | 0.4 | 0.4 | -0.2 | 0.3 | -0.4 | 0.4 | -0.8 | -0.2 | 0.6 | -0.5 | 0.3 | -0.0 | 0.5 | 0.4 | -0.3 | 0.6 | -0.3 | 0.2 | -0.5 |
Reaction time mean AUC | 0.1 | 0.2 | 0.5 | 0.5 | -0.2 | -0.4 | 0.4 | 0.3 | -0.2 | 0.3 | -0.4 | 0.4 | -0.7 | -0.2 | 0.6 | -0.5 | 0.3 | -0.0 | 0.5 | 0.4 | -0.3 | 0.5 | -0.3 | 0.2 | -0.5 |
Social response proportion | 0.1 | 0.1 | 0.6 | -0.1 | 0.4 | -0.2 | 0.2 | 0.1 | 0.2 | -0.4 | 0.0 | 0.1 | -0.6 | -0.1 | -0.8 | 0.5 | 0.0 | 0.6 | 0.0 | -0.2 | -0.0 | 0.5 | 0.1 | -0.5 | -0.2 |
Cocaine response before conditioning | 0.1 | 0.2 | 0.5 | 0.5 | -0.7 | -0.3 | 0.3 | 0.2 | -0.1 | 0.4 | -0.4 | 0.5 | -0.7 | -0.4 | 0.3 | 0.0 | 0.6 | -0.2 | 0.4 | 0.5 | 0.0 | 0.5 | -0.6 | -0.0 | -0.4 |
Saline control response | 0.1 | 0.2 | 0.6 | 0.2 | -0.4 | 0.5 | -0.7 | -0.7 | 0.5 | -0.2 | 0.3 | 0.1 | -0.2 | 0.5 | -0.3 | 0.5 | -0.1 | 0.3 | -0.1 | 0.3 | 0.7 | -0.2 | -0.4 | -0.5 | 0.3 |
Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 1.1 | 0.0 | -0.0 | -0.1 | 0.2 | 0.5 | -0.2 | -0.0 | 0.0 | -0.1 | 1.0 | -0.3 | -0.3 | 0.1 | 0.2 | -0.7 | -0.3 | -0.1 | -0.2 | -0.1 | 0.1 | 0.5 | 0.2 |
Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 1.0 | -0.4 | 0.4 | -0.2 | 0.2 | 0.5 | -0.1 | -0.3 | 0.1 | -0.3 | 1.0 | -0.3 | -0.2 | 0.1 | 0.0 | -0.5 | -0.4 | -0.3 | -0.2 | -0.0 | 0.3 | 0.3 | 0.3 |
Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.5 | 0.6 | -0.6 | -0.3 | 0.4 | 0.7 | -0.2 | 0.2 | -0.3 | 0.3 | 0.2 | -0.4 | -0.0 | 0.1 | 0.5 | -0.4 | 0.1 | 0.2 | -0.2 | 0.4 | 0.0 | 0.3 | -0.3 |
Intermitt. access escalation Index | 0.1 | 0.1 | 0.5 | 0.5 | -0.0 | -0.3 | 0.3 | 0.7 | -0.3 | -0.1 | -0.2 | 0.1 | 0.2 | -0.2 | 0.2 | 0.0 | 0.3 | -0.3 | 0.0 | -0.0 | -0.3 | 0.3 | 0.2 | 0.2 | -0.3 |
Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | -0.2 | -0.2 | 0.3 | -0.2 | -0.2 | 0.2 | -0.2 | 0.3 | -0.3 | 0.4 | 0.2 | -0.1 | 0.3 | -0.3 | 0.2 | -0.3 | -0.3 | 0.2 | -0.4 | 0.4 | -0.2 | 0.3 |
Intermittent access day 15 total locomotion | 0.1 | 0.2 | 0.4 | -0.6 | 0.4 | 0.3 | -0.3 | -0.2 | 0.2 | -0.4 | 0.3 | -0.5 | 0.5 | 0.3 | -0.4 | 0.3 | -0.4 | 0.3 | -0.4 | -0.5 | 0.3 | -0.4 | 0.5 | -0.3 | 0.4 |
Post-drug Anxiety | 0.1 | 0.1 | 0.7 | -0.5 | 0.8 | 0.0 | -0.1 | 0.1 | 0.2 | -0.7 | 0.3 | -0.5 | 0.4 | 0.1 | -0.3 | 0.2 | -0.3 | 0.2 | -0.4 | -0.6 | 0.1 | -0.1 | 0.4 | -0.2 | 0.3 |
Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.4 | 0.3 | -0.4 | -0.4 | 0.6 | 0.5 | -0.2 | 0.4 | -0.3 | 0.3 | 0.3 | -0.6 | 0.3 | -0.2 | 0.3 | -0.6 | 0.1 | 0.2 | -0.3 | 0.3 | -0.1 | 0.6 | -0.2 |
Progressive ratio test 2 active lever presses | 0.1 | 0.1 | 0.5 | 0.0 | -0.2 | -0.0 | 0.4 | 0.3 | -0.1 | 0.4 | -0.0 | -0.0 | 0.7 | -0.3 | 0.2 | -0.0 | -0.0 | -0.4 | -0.2 | -0.1 | -0.2 | -0.1 | 0.2 | 0.5 | 0.1 |
Progressive ratio test 2 breakpoint | 0.1 | 0.1 | 0.6 | -0.2 | 0.0 | 0.0 | 0.3 | 0.2 | 0.1 | 0.1 | 0.1 | -0.1 | 0.8 | -0.2 | 0.0 | 0.2 | -0.1 | -0.2 | -0.3 | -0.3 | 0.0 | -0.1 | 0.4 | 0.3 | 0.2 |
Short access day 10 total locomotion | 0.1 | 0.1 | 0.7 | 0.2 | -0.4 | -0.1 | 0.3 | 0.2 | 0.2 | -0.0 | -0.2 | 0.1 | -0.8 | -0.1 | -0.3 | 0.2 | 0.1 | 0.6 | 0.2 | 0.0 | 0.2 | 0.4 | 0.3 | -0.6 | -0.5 |
Locomotion distance, session 7 | 0.1 | 0.1 | 0.6 | -0.4 | 0.3 | -0.1 | 0.5 | 0.0 | -0.3 | 0.8 | -0.2 | 0.2 | -0.2 | -0.3 | 0.7 | -0.2 | -0.0 | -0.1 | 0.2 | -0.1 | -0.5 | 0.1 | 0.0 | 0.4 | -0.3 |
Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.7 | 0.1 | 0.2 | 0.4 | -0.4 | -0.2 | 0.2 | -0.2 | 0.3 | -0.4 | 0.8 | 0.4 | 0.0 | 0.2 | -0.2 | -0.0 | -0.4 | -0.3 | 0.2 | -0.7 | 0.4 | -0.0 | 0.4 |
Time in familiar zone, hab. session 2 | 0.1 | 0.1 | 0.4 | 0.3 | -0.0 | 0.5 | -0.5 | -0.6 | 0.2 | -0.1 | 0.1 | -0.2 | -0.4 | 0.4 | 0.4 | 0.0 | -0.3 | 0.6 | 0.0 | -0.1 | 0.3 | -0.4 | 0.1 | -0.5 | 0.1 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.6 | -0.3 | 0.0 | -0.2 | 0.1 | 0.3 | 0.1 | -0.3 | 0.1 | 0.1 | 0.6 | -0.1 | -0.8 | 0.2 | 0.1 | -0.3 | -0.2 | -0.0 | 0.0 | 0.2 | 0.0 | 0.3 | 0.2 |
Bone surface | 0.1 | 0.2 | 1.1 | 0.2 | -0.4 | -0.4 | 0.1 | 0.6 | -0.5 | 0.1 | -0.3 | 0.4 | 0.3 | -0.4 | 0.3 | -0.7 | 0.6 | -1.1 | 0.3 | 0.5 | -0.2 | 0.2 | -0.6 | 0.7 | -0.1 |
Bone: connectivity density | 0.1 | 0.2 | 0.4 | -0.2 | -0.2 | -0.6 | 0.5 | 0.6 | -0.6 | 0.3 | -0.4 | 0.4 | -0.3 | -0.5 | 0.4 | -0.7 | 0.4 | -0.6 | 0.4 | 0.4 | -0.6 | 0.5 | -0.4 | 0.6 | -0.4 |
Bone: cortical thickness | 0.1 | 0.2 | 0.6 | -0.7 | 0.6 | 0.2 | -0.1 | 0.0 | 0.4 | -0.5 | 0.4 | -0.5 | 0.7 | 0.2 | -0.0 | 0.6 | -0.3 | 0.4 | -0.6 | -0.7 | 0.3 | -0.2 | 0.8 | -0.3 | 0.4 |
Bone: elastic displacement | 0.1 | 0.1 | 0.4 | -0.2 | 0.1 | 0.3 | -0.6 | -0.2 | 0.2 | -0.5 | 0.3 | -0.2 | 0.5 | 0.5 | -0.3 | -0.0 | -0.2 | -0.1 | -0.2 | -0.0 | 0.4 | -0.4 | 0.0 | -0.1 | 0.5 |
Bone: tissue strength | 0.1 | 0.1 | 0.4 | -0.3 | 0.4 | 0.2 | -0.3 | -0.0 | 0.2 | -0.6 | 0.3 | -0.4 | 0.6 | 0.2 | -0.2 | 0.1 | -0.3 | -0.0 | -0.4 | -0.4 | 0.3 | -0.3 | 0.4 | -0.1 | 0.4 |
Breakpoint value in progressive ratio session | 0.1 | 0.1 | 0.4 | 0.0 | -0.5 | -0.5 | 0.5 | 0.6 | -0.2 | 0.1 | -0.4 | 0.4 | -0.4 | -0.4 | 0.2 | -0.4 | 0.3 | -0.2 | 0.3 | 0.3 | -0.2 | 0.6 | -0.2 | 0.2 | -0.4 |
Distance traveled before self-admin | 0.1 | 0.1 | 0.4 | 0.6 | -0.1 | -0.2 | 0.6 | 0.2 | 0.0 | 0.4 | -0.2 | 0.2 | -0.4 | -0.4 | -0.2 | 0.2 | 0.1 | 0.3 | 0.1 | -0.0 | -0.3 | 0.4 | 0.1 | -0.1 | -0.4 |
Distance traveled after self-admin | 0.1 | 0.1 | 0.7 | 0.2 | -0.2 | -0.2 | 0.1 | 0.8 | 0.2 | -0.5 | -0.0 | -0.1 | 0.7 | -0.2 | -0.2 | 0.3 | 0.3 | -0.2 | -0.3 | -0.1 | 0.2 | 0.1 | 0.2 | -0.0 | -0.0 |
Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.6 | -0.8 | -0.0 | 0.2 | -0.2 | -0.2 | 0.4 | -0.3 | 0.3 | -0.1 | 0.1 | 0.2 | -0.3 | 0.4 | -0.2 | 0.4 | -0.3 | -0.2 | 0.3 | -0.0 | 0.2 | -0.3 | 0.2 |
Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.3 | -0.0 | -0.2 | -0.3 | 0.3 | 0.1 | -0.2 | 0.2 | -0.2 | 0.3 | -0.5 | -0.2 | -0.1 | -0.1 | 0.2 | -0.0 | 0.3 | 0.2 | -0.2 | 0.4 | -0.3 | 0.1 | -0.3 |
Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.3 | 0.1 | 0.3 | 0.2 | -0.4 | -0.2 | 0.1 | -0.2 | 0.2 | 0.1 | 0.5 | 0.2 | -0.5 | 0.1 | -0.0 | -0.3 | -0.2 | 0.1 | 0.3 | -0.3 | -0.2 | 0.1 | 0.4 |
Ambulatory time before self-admin | 0.1 | 0.1 | 0.6 | 0.8 | -0.5 | -0.1 | 0.6 | 0.3 | -0.0 | 0.5 | -0.2 | 0.2 | -0.2 | -0.3 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | 0.1 | -0.0 | -0.4 |
Area under the delay curve | 0.1 | 0.1 | 0.5 | 0.4 | -0.2 | -0.2 | 0.4 | 0.3 | -0.3 | 0.7 | -0.4 | 0.4 | 0.0 | -0.5 | 0.6 | -0.2 | 0.4 | -0.5 | 0.2 | 0.3 | -0.4 | 0.1 | -0.2 | 0.5 | -0.4 |
Delay disc. indifference point, 2s delay | 0.1 | 0.1 | 0.4 | -0.3 | 0.4 | 0.5 | -0.3 | -0.4 | 0.5 | -0.0 | 0.3 | -0.2 | 0.4 | 0.3 | -0.2 | 0.6 | -0.3 | 0.5 | -0.5 | -0.4 | 0.3 | -0.5 | 0.5 | -0.5 | 0.2 |
Delay discount hyperbolic model param | 0.1 | 0.1 | 0.3 | -0.3 | 0.2 | 0.1 | -0.3 | -0.2 | 0.2 | -0.6 | 0.2 | -0.3 | -0.2 | 0.3 | -0.5 | -0.0 | -0.3 | 0.3 | -0.1 | -0.2 | 0.3 | -0.0 | 0.1 | -0.3 | 0.2 |
Time >=10cm from walls, locomotor time 1 | 0.1 | 0.1 | 0.2 | -0.3 | 0.4 | 0.1 | -0.2 | -0.1 | 0.2 | -0.3 | 0.2 | -0.3 | 0.2 | 0.1 | -0.0 | 0.1 | -0.1 | 0.1 | -0.2 | -0.3 | 0.4 | -0.2 | 0.3 | -0.2 | 0.2 |
Total resting periods, locomotor time 1 | 0.1 | 0.1 | 0.9 | -0.8 | 0.9 | 0.2 | 0.1 | -0.3 | 0.2 | 0.1 | 0.2 | -0.3 | 0.2 | 0.1 | 0.3 | 0.0 | -0.5 | 0.3 | -0.2 | -0.6 | -0.0 | -0.3 | 0.4 | 0.0 | 0.2 |
Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.5 | 0.6 | -0.4 | -0.4 | 0.2 | 0.7 | -0.3 | 0.0 | -0.4 | 0.3 | -0.2 | -0.3 | 0.5 | -0.3 | 0.6 | -0.4 | 0.2 | 0.3 | -0.2 | 0.3 | -0.3 | 0.2 | -0.4 |
Total resting periods, locomotor time 2 | 0.1 | 0.2 | 0.7 | -0.8 | 0.6 | 0.2 | 0.0 | -0.1 | 0.3 | -0.2 | 0.3 | -0.3 | 0.4 | 0.2 | -0.4 | 0.4 | -0.4 | 0.5 | -0.4 | -0.6 | 0.0 | -0.2 | 0.6 | -0.3 | 0.2 |
Rest time, locomotor task time 2 | 0.1 | 0.1 | 0.4 | -0.0 | -0.1 | -0.3 | 0.5 | 0.5 | -0.3 | 0.5 | -0.3 | 0.3 | 0.1 | -0.5 | 0.4 | -0.3 | 0.4 | -0.6 | 0.2 | 0.2 | -0.4 | 0.2 | -0.2 | 0.6 | -0.3 |
Weight adjusted by age | 0.1 | 0.1 | 0.3 | 0.4 | -0.0 | 0.2 | -0.5 | -0.1 | 0.0 | -0.4 | 0.2 | -0.1 | 0.6 | 0.4 | -0.1 | -0.2 | -0.0 | -0.3 | -0.2 | 0.0 | 0.2 | -0.5 | -0.1 | 0.0 | 0.3 |
BMI without tail | 0.0 | 0.1 | 0.4 | 0.0 | -0.2 | 0.0 | -0.1 | -0.0 | 0.3 | -0.4 | 0.1 | -0.0 | -0.6 | 0.4 | 0.1 | 0.1 | -0.1 | 0.6 | 0.0 | -0.1 | 0.2 | 0.2 | 0.1 | -0.6 | -0.1 |
Delay discounting total patch changes 12 sec | 0.0 | 0.1 | 0.3 | 0.0 | -0.3 | -0.2 | 0.2 | 0.4 | -0.2 | -0.0 | -0.1 | 0.2 | 0.5 | -0.5 | 0.1 | 0.0 | 0.3 | -0.5 | -0.0 | 0.1 | 0.0 | 0.2 | 0.1 | 0.3 | 0.0 |
Delay discounting water rate 24 sec | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.2 | 0.1 | 0.3 | -0.1 | -0.4 | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | -0.2 | 0.0 | -0.2 | -0.0 | -0.1 | -0.1 | 0.2 | 0.0 | 0.3 | 0.2 |
Locomotor testing distance | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | -0.0 | 0.0 | 0.3 | -0.2 | 0.0 | -0.2 | 0.1 | 0.1 | -0.0 | 0.0 | -0.1 | 0.2 | -0.1 |
Social responses | 0.0 | 0.0 | 0.2 | 0.3 | -0.2 | -0.1 | -0.0 | 0.2 | -0.2 | 0.1 | -0.2 | 0.3 | 0.0 | -0.2 | 0.3 | -0.0 | 0.3 | -0.4 | 0.1 | 0.4 | -0.0 | 0.1 | -0.4 | 0.2 | -0.1 |
Cocaine response after cond. corrected | 0.0 | 0.0 | 0.2 | -0.4 | 0.3 | 0.2 | -0.3 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.1 | 0.2 | 0.0 | 0.1 | -0.2 | 0.2 | -0.2 | -0.2 | 0.3 | -0.3 | 0.1 | -0.2 | 0.2 |
Cocaine response after cond. not corrected | 0.0 | 0.0 | 0.2 | -0.2 | 0.0 | 0.1 | -0.3 | -0.2 | 0.2 | -0.2 | 0.1 | 0.0 | -0.2 | 0.1 | 0.0 | 0.2 | 0.0 | 0.2 | -0.0 | -0.0 | 0.4 | -0.1 | -0.1 | -0.3 | 0.1 |
Intermittent access day 15 total infusions | 0.0 | 0.0 | 0.3 | 0.1 | -0.5 | -0.0 | 0.2 | 0.3 | -0.1 | 0.0 | -0.0 | -0.1 | 0.4 | -0.1 | 0.1 | 0.1 | 0.1 | -0.2 | -0.1 | -0.1 | -0.2 | 0.0 | 0.3 | 0.2 | -0.0 |
Bone volume | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | -0.2 | -0.0 | 0.2 | -0.2 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.0 | -0.3 | 0.2 | -0.4 | 0.1 | 0.2 | -0.0 | 0.1 | -0.3 | 0.2 | 0.0 |
Bone: trabecular number | 0.0 | 0.0 | 0.2 | -0.5 | 0.2 | 0.2 | -0.2 | -0.3 | 0.0 | -0.0 | 0.1 | -0.3 | -0.1 | 0.3 | 0.3 | -0.2 | -0.3 | 0.2 | -0.0 | -0.1 | 0.0 | -0.3 | 0.1 | -0.2 | 0.1 |
Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | -0.1 | 0.1 | 0.1 | -0.0 | 0.1 | -0.0 | 0.1 | 0.1 | -0.1 | 0.1 | -0.0 | 0.1 | -0.1 | -0.0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 |
Total heroin consumption | 0.0 | 0.0 | 0.3 | -0.3 | -0.1 | -0.0 | 0.0 | 0.2 | 0.1 | -0.1 | 0.1 | 0.1 | 0.5 | -0.1 | -0.2 | 0.0 | 0.0 | -0.2 | -0.2 | -0.0 | 0.1 | -0.1 | -0.0 | 0.2 | 0.2 |
Delay disc. indifference point, 4s delay | 0.0 | 0.1 | 0.2 | 0.3 | -0.2 | -0.1 | 0.3 | 0.4 | 0.0 | 0.1 | -0.0 | 0.2 | 0.5 | -0.3 | -0.0 | 0.4 | 0.2 | -0.3 | -0.1 | -0.0 | -0.2 | 0.2 | 0.2 | 0.2 | -0.0 |
Vertical activity count, locomotor time 1 | 0.0 | 0.0 | 0.1 | 0.3 | -0.3 | -0.0 | -0.1 | -0.1 | -0.1 | -0.2 | 0.0 | -0.1 | -0.1 | 0.0 | -0.2 | 0.1 | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | 0.1 | -0.1 | -0.1 | 0.1 |
Fe content in liver | 0.0 | 0.0 | 0.2 | 0.1 | -0.1 | 0.0 | -0.3 | -0.2 | 0.2 | -0.5 | 0.1 | -0.0 | -0.3 | 0.2 | -0.2 | 0.2 | -0.0 | 0.2 | 0.0 | 0.0 | 0.5 | 0.1 | -0.2 | -0.4 | 0.2 |
Rb content in liver | 0.0 | 0.0 | 0.2 | 0.4 | -0.1 | -0.1 | 0.1 | 0.2 | -0.1 | 0.0 | -0.0 | 0.0 | 0.3 | -0.2 | -0.0 | 0.1 | 0.1 | -0.3 | -0.0 | 0.0 | 0.0 | 0.1 | -0.0 | 0.2 | 0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.