Hub : Genes

Atp5mc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000069121 0.33 0.11 0.0e+00 0.37 0.06 0.36 0.08 2.4e-43 1.7e-07 2.8e-42 6.7e-09
2 Liver intron excision ratio chr10:81026083:81026596 0.22 0.12 9.3e-15 0.13 -0 0.13 -0 1.2e-14 6.2e-01 1.7e-14 8.0e-01
3 Liver intron excision ratio chr10:81026083:81026666 0.17 0.1 1.7e-15 0.13 0 0.13 0.04 2.9e-14 1.2e-01 1.5e-14 4.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail18.860.961.47.87.8-7.7
BMI without tail0.91.92.01.41.4-1.3
Body weight1.25.25.32.32.3-2.2
Epididymis fat weight0.20.60.60.80.8-0.6
Glucose0.71.11.31.01.0-1.1
Heart weight1.72.42.51.61.6-1.5
Left kidney weight0.00.00.00.10.1-0.1
Right kidney weight0.51.51.51.21.2-1.2
Tail length17.252.152.2-7.2-7.27.2
Length with tail7.728.428.5-5.3-5.35.3
Length without tail0.10.10.10.30.3-0.3
Liver weight, left0.81.21.4-1.1-1.11.2
Liver weight, right0.20.40.5-0.6-0.60.7
Parametrial fat weight0.10.20.2-0.5-0.50.4
Retroperitoneal fat weight0.31.01.01.01.0-1.0
Intraocular pressure0.81.11.4-1.0-1.01.2
Extensor digitorum longus weight0.93.73.71.91.9-1.9
Soleus weight1.64.74.82.22.2-2.1
Tibialis anterior weight0.10.20.2-0.5-0.50.5
Tibia length0.71.92.01.41.4-1.3
Number of licking bursts0.81.01.0-1.0-1.01.0
Food consumed during 24 hour testing period2.32.82.9-1.7-1.71.6
Times rat made contact with spout0.91.11.1-1.1-1.11.0
Mean time between licks in bursts1.11.51.61.31.3-1.2
Mean num. licks in bursts0.00.00.00.10.1-0.2
Std. dev. time between licks in bursts0.70.80.80.90.9-0.9
Water consumed over 24 hours0.10.10.2-0.4-0.40.3
Indifference point 0 sec1.42.32.41.51.5-1.5
Indifference point AUC0.10.10.1-0.3-0.30.1
Indifference point function ln k0.00.00.0-0.1-0.10.2
Indifference point function log k0.00.00.0-0.1-0.10.2
Delay discounting total patch changes 0 sec1.72.72.81.61.6-1.7
Delay discounting total patch changes 12 sec0.10.20.20.40.4-0.4
Delay discounting total patch changes 18 sec2.53.33.61.81.8-1.9
Delay discounting total patch changes 24 sec1.21.51.61.21.2-1.3
Delay discounting total patch changes 6 sec1.21.81.91.31.3-1.4
Delay discounting time to switch 0 sec0.00.10.1-0.2-0.20.3
Delay discounting water rate 0 sec1.82.93.01.71.7-1.7
Delay discounting water rate 12 sec0.71.01.01.01.0-0.9
Delay discounting water rate 18 sec0.00.00.00.00.0-0.1
Delay discounting water rate 24 sec1.42.02.11.41.4-1.5
Delay discounting water rate 6 sec0.10.10.10.30.3-0.3
Locomotor activity0.20.30.30.60.6-0.5
Locomotor testing distance0.61.01.01.01.0-0.9
Locomotor testing rearing0.20.30.40.60.6-0.5
Light reinforcement 10.10.10.10.40.4-0.1
Light reinforcement 20.50.60.7-0.8-0.80.8
Reaction time number correct1.62.42.51.61.6-1.4
Reaction time mean minus median2.43.13.2-1.8-1.81.7
Reaction time mean minus median AUC3.24.14.2-2.0-2.02.0
Reaction time num false alarms1.11.61.6-1.2-1.21.3
Reaction time num false alarms AUC1.21.61.6-1.3-1.31.3
Reaction time trials correct on left1.62.42.51.61.6-1.4
Reaction time trials on left1.52.22.31.51.5-1.3
Reaction time mean1.42.02.0-1.4-1.41.4
Reaction time mean AUC1.82.42.4-1.5-1.51.5
Median of all reaction times0.50.70.8-0.8-0.80.9
Reaction time omissions1.41.81.9-1.4-1.41.3
Reaction time false alarm rate2.13.03.1-1.8-1.81.7
Reaction time premature initiation rate0.30.40.4-0.7-0.70.6
Reaction time premature initiations0.00.00.00.10.1-0.0
Std. dev. reaction times2.43.33.3-1.8-1.81.8
Reaction time trials completed1.52.22.31.51.5-1.3
Reaction time trials AUC1.62.32.51.61.6-1.4
Social response proportion2.93.13.2-1.8-1.81.7
Social responses0.00.10.1-0.2-0.20.2
Social time0.00.00.00.10.1-0.1
Conditioned locomotion1.82.12.51.41.4-1.6
Cocaine response after cond. corrected6.16.86.92.62.6-2.6
Cocaine response after cond. not corrected3.63.94.02.02.0-2.0
Cocaine response before conditioning2.83.43.4-1.8-1.81.8
Saline control response0.10.20.20.40.4-0.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.10.3
Condit. Reinf. active-inactive response ratio0.00.00.1-0.1-0.10.3
Condit. Reinf. active responses0.00.00.00.00.00.2
Condit. Reinf. inactive responses0.00.00.00.20.2-0.1
Condit. Reinf. lever presses0.30.50.5-0.7-0.70.7
Condit. Reinf. lever reinforcers received0.00.00.1-0.0-0.00.3
Pavlov. Cond. lever latency1.42.02.2-1.4-1.41.5
Pavlov. Cond. magazine entry latency0.91.11.2-1.1-1.10.9
Pavlov. Cond. change in total contacts0.30.40.50.50.5-0.7
Pavlov. Cond. index score0.20.20.30.40.4-0.5
Pavlov. Cond. latency score0.00.00.10.10.1-0.3
Pavlov. Cond. lever contacts0.91.31.41.11.1-1.2
Pavlov. Cond. magazine entry number0.00.00.00.10.10.0
Pavlov. Cond. intertrial magazine entries1.01.31.6-1.1-1.11.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.50.5-0.7
Pavlov. Cond. response bias0.60.80.90.90.9-1.0
Conditioned reinforcement - actives0.00.00.1-0.1-0.10.3
Conditioned reinforcement - inactives0.00.00.00.10.10.0
Conditioned locomotion0.10.20.20.40.4-0.3
Intermittent access intake day 1-15 change1.11.11.21.01.0-1.1
Intermittent access intake escalation0.50.50.60.70.7-0.7
Intermittent access intake escalation 20.60.60.80.80.8-0.9
Intermitt. access day 1 inactive lever presses0.00.00.00.10.1-0.0
Intermitt. access day 15 inactive lever presses1.71.92.01.31.3-1.4
Intermitt. access escalation Index0.20.20.2-0.4-0.40.4
Intermittent access day 1 total infusions0.91.11.2-1.0-1.01.1
Intermittent access day 15 total infusions0.40.40.4-0.7-0.70.6
Intermittent access terminal intake (last 3 days)0.10.10.1-0.2-0.20.3
Intermittent access total infusions0.10.10.1-0.2-0.20.3
Intermittent access day 1 locomotion2.32.42.7-1.5-1.51.7
Intermittent access day 15 total locomotion0.20.30.3-0.5-0.50.6
Intermittent access total locomotion0.40.40.6-0.6-0.60.8
Intermittent access standard deviation1.01.11.21.01.0-1.1
Cocaine induced anxiety0.10.10.10.30.3-0.2
Post-drug Anxiety0.60.70.8-0.8-0.80.9
Baseline Anxiety0.00.00.00.10.1-0.1
Lifetime Intake0.20.20.3-0.5-0.50.6
Incentive Sensitization - Responses0.10.10.10.40.4-0.1
Incentive Sensitization - Breakpoint0.30.30.40.60.6-0.3
Progressive ratio test 1 active lever presses1.01.01.1-1.0-1.01.1
Progressive ratio test 1 breakpoint1.11.21.3-1.1-1.11.1
Progressive ratio test 1 inactive lever presses0.20.20.20.50.5-0.4
Progressive ratio test 2 active lever presses0.50.60.8-0.7-0.70.9
Progressive ratio test 2 breakpoint0.20.20.3-0.3-0.30.6
Progressive ratio test 2 inactive lever presses0.00.00.00.10.1-0.1
Total sessions with >9 infusions1.21.31.3-1.1-1.11.1
Short access day 1 total inactive lever presses0.10.10.1-0.3-0.30.4
Short access day 10 total inactive lever presses0.50.60.60.70.7-0.8
Short access day 1 total infusions0.10.10.1-0.2-0.20.3
Short access day 10 total infusions0.10.10.1-0.2-0.20.3
Short access total infusions0.00.00.0-0.1-0.10.2
Short access day 1 locomotion0.00.00.0-0.2-0.20.1
Short access day 10 total locomotion1.21.31.5-1.1-1.11.2
Short access total locomotion0.30.30.4-0.5-0.50.6
Compulsive drug intake6.96.97.2-2.6-2.62.7
One hour access (0.3 mA shock)0.50.50.7-0.7-0.70.8
One hour access (shock baseline)1.41.71.71.31.3-1.3
Number of responses in last shaping day2.42.42.41.51.5-1.6
Context. condit. distance diff. score1.31.61.61.31.3-1.2
Locomotion velocity, session 10.00.00.0-0.1-0.10.2
Locomotion distance, session 14.86.26.4-2.5-2.52.5
Locomotion velocity, session 21.41.61.6-1.3-1.31.2
Locomotion distance, session 26.79.69.6-3.1-3.13.1
Locomotion velocity, session 30.30.30.40.60.6-0.6
Locomotion distance, session 31.31.41.5-1.2-1.21.2
Stereotopy head waving bouts, day 34.04.74.82.22.2-2.2
Stereotopy head waving duration, day 33.03.73.91.91.9-2.0
Locomotion velocity, session 70.91.01.1-0.9-0.91.1
Locomotion distance, session 75.16.57.2-2.5-2.52.7
Stereotopy head waving bouts, day 70.30.30.30.60.6-0.6
Stereotopy head waving duration, day 70.10.10.20.40.4-0.4
Locomotion velocity, session 80.30.40.50.60.6-0.7
Locomotion distance, session 80.40.60.7-0.8-0.80.8
Degree of sensitization distance0.00.00.1-0.1-0.10.3
Degree of sensitization stereotypy0.30.40.4-0.6-0.60.6
Condit. Reinf. active minus inactive responses1.21.31.3-1.2-1.21.2
Condit. Reinf. active-inactive response ratio0.00.00.00.00.0-0.1
Condit. Reinf. active responses1.31.61.7-1.3-1.31.3
Condit. Reinf. inactive responses1.11.31.4-1.1-1.11.2
Incentive salience index mean2.22.62.7-1.6-1.61.6
Condit. Reinf. lever presses2.73.63.7-1.9-1.91.9
Time in familiar zone, hab. session 10.00.00.0-0.1-0.10.1
Time in novel zone, hab. session 11.61.61.71.21.2-1.3
Total zone transitions, hab. session 16.49.19.6-3.0-3.03.1
Total locomotion distance, hab. session 13.75.35.6-2.3-2.32.4
Locomotion velocity, hab. session 14.66.67.0-2.5-2.52.6
Time in familiar zone, hab. session 21.21.31.31.11.1-1.1
Time in novel zone, hab. session 20.10.10.1-0.3-0.30.3
Total zone transitions, hab. session 24.66.06.2-2.4-2.42.5
Total locomotion distance, hab. session 21.01.31.4-1.1-1.11.2
Locomotion velocity, hab. session 21.31.71.8-1.3-1.31.3
Novel to familiar place preference ratio0.10.10.1-0.3-0.30.3
Novelty place preference0.10.10.1-0.3-0.30.3
Time in novel zone, NPP test0.00.00.0-0.1-0.10.1
Total zone transitions, NPP test6.08.68.7-2.9-2.93.0
Total locomotion distance, NPP test1.72.42.4-1.5-1.51.6
Locomotion velocity, NPP test2.33.33.3-1.8-1.81.8
Pavlov. Cond. lever latency1.31.61.81.31.3-1.3
Pavlov. Cond. magazine entry latency0.20.20.2-0.5-0.50.5
Pavlov. Cond. change in total contacts3.73.94.1-2.0-2.02.0
Pavlov. Cond. index score0.91.11.2-1.0-1.01.1
Pavlov. Cond. latency score0.91.11.3-1.0-1.01.1
Pavlov. Cond. lever contacts2.42.92.9-1.7-1.71.7
Pavlov. Cond. magazine entry number0.50.60.60.80.8-0.8
Pavlov. Cond. intertrial magazine entries0.91.01.1-1.0-1.01.1
Pavlov. Cond. lever-magazine prob. diff.0.81.01.1-1.0-1.01.0
Pavlov. Cond. response bias0.70.80.8-0.9-0.90.9
Bone: apparent density1.42.42.41.51.5-1.5
Bone surface0.50.90.90.90.9-1.0
Bone volume1.11.91.91.41.4-1.4
Bone: connectivity density0.40.70.70.80.8-0.8
Bone: cortical apparent density5.57.27.2-2.7-2.72.7
Bone: cortical area0.50.70.80.80.8-0.9
Bone: cortical porosity0.40.40.40.70.7-0.7
Bone: cortical porosity0.30.30.30.50.5-0.5
Bone: cortical thickness0.10.20.30.40.4-0.5
Bone: cortical thickness0.40.40.4-0.6-0.60.6
Bone: cortical tissue density6.18.08.0-2.8-2.82.8
Bone: elastic displacement0.00.00.00.10.1-0.2
Bone: elastic work0.00.00.00.10.1-0.1
Bone: endosteal estimation0.10.20.20.50.5-0.4
Bone: endosteal perimeter0.20.40.50.70.7-0.6
Bone: final force0.20.30.40.60.6-0.5
Bone: final moment0.30.50.50.70.7-0.7
Bone: marrow area0.00.10.10.40.4-0.2
Bone: maximum diameter0.30.60.60.80.8-0.8
Bone: maximum force0.81.41.41.21.2-1.2
Bone: maximum moment0.91.61.71.31.3-1.3
Bone: minimum diameter0.00.00.00.20.2-0.1
Bone: periosteal estimation0.40.91.01.01.0-0.9
Bone: periosteal perimeter1.11.81.81.31.3-1.3
Bone: post-yield work0.71.01.01.01.0-1.0
Bone: stiffness0.10.20.20.50.5-0.5
Bone: tissue strength1.21.21.21.11.1-1.1
Bone: trabecular number0.20.20.30.50.5-0.5
Bone: trabecular spacing0.00.00.00.00.0-0.0
Bone: trabecular thickness3.54.24.32.02.0-2.1
Bone: trabecular tissue density0.00.00.0-0.1-0.10.1
Breakpoint value in progressive ratio session3.43.83.8-1.9-1.92.0
Distance traveled before self-admin1.71.81.9-1.3-1.31.4
Distance traveled after self-admin0.20.30.30.50.5-0.5
Delta time in closed arm before/after self-admin0.10.00.10.20.2-0.3
Delta time in open arm before/after self-admin0.00.00.00.10.1-0.0
Diff in mean of infusions in LGA sessions1.71.91.9-1.4-1.41.4
Extinction: sum of active levers before priming0.60.70.7-0.8-0.80.8
Active lever presses in extinction session 60.00.00.00.10.1-0.1
Delta distance traveled before/after self-admin2.83.03.01.71.7-1.7
Delta ambulatory time before/after self-admin2.62.92.91.71.7-1.7
Time in closed arm before self-admin3.13.63.61.91.9-1.9
Time in closed arm after self-admin3.03.23.31.81.8-1.8
Time in open arm before self-admin0.40.40.4-0.6-0.60.7
Time in open arm after self-admin0.20.20.3-0.5-0.50.5
Sum of active levers in priming session hrs 5-65.85.75.7-2.4-2.42.4
Time to tail flick, vehicle, before self-admin1.61.61.6-1.3-1.31.3
Time to tail flick, vehicle, after self-admin0.80.90.90.90.9-1.0
Time to tail flick, test, before self-admin0.30.30.30.50.5-0.6
Time to tail flick, test, after self-admin0.40.40.40.60.6-0.6
Delta time to tail flick, vehicle, before/after SA3.43.33.51.81.8-1.9
Delta time to tail flick, test, before/after SA0.30.20.3-0.5-0.50.5
Ambulatory time before self-admin0.80.80.9-0.9-0.90.9
Ambulatory time after self-admin0.60.70.70.80.8-0.8
Total heroin consumption0.60.80.8-0.9-0.90.8
Area under the delay curve0.00.00.00.10.1-0.1
Delay disc. indifference point, 0s delay0.10.10.10.20.2-0.2
Delay disc. indifference point, 16s delay1.31.31.31.11.1-1.1
Delay disc. indifference point, 2s delay0.00.00.0-0.0-0.00.1
Delay disc. indifference point, 24s delay0.60.60.6-0.8-0.80.8
Delay disc. indifference point, 4s delay0.70.70.8-0.8-0.80.9
Delay disc. indifference point, 8s delay0.00.00.0-0.1-0.10.2
Delay discount exponential model param0.00.00.00.00.0-0.1
Delay discount hyperbolic model param0.00.00.00.10.1-0.1
Fecal boli incidents, locomotor time 12.42.62.71.61.6-1.6
Change in fecal boli incidents, locomotor task1.41.31.5-1.1-1.11.2
Time >=10cm from walls, locomotor time 10.00.00.0-0.0-0.00.0
Bouts of movement, locomotor time 10.30.40.40.60.6-0.5
Total resting periods, locomotor time 10.70.80.80.90.9-0.8
Rest time, locomotor task time 10.00.00.10.20.2-0.3
Distance moved, locomotor task time 12.22.42.6-1.5-1.51.6
Vertical activity count, locomotor time 10.30.30.4-0.5-0.50.6
Time >=10cm from walls, locomotor time 20.30.40.4-0.6-0.60.5
Bouts of movement, locomotor time 20.10.10.10.30.3-0.3
Total resting periods, locomotor time 20.20.20.20.40.4-0.4
Rest time, locomotor task time 20.60.70.7-0.9-0.90.8
Distance moved, locomotor task time 20.10.10.2-0.4-0.40.4
Vertical activity count, locomotor time 20.00.00.0-0.1-0.10.1
Weight adjusted by age0.00.10.1-0.3-0.30.2
Seeking ratio, delayed vs. immediate footshock2.22.62.71.71.7-1.5
Locomotion in novel chamber0.00.00.0-0.2-0.20.1
Locomotion in novel chamber post-restriction2.12.52.61.61.6-1.6
Progressive ratio0.20.20.20.40.4-0.4
Food seeking constrained by brief footshock0.00.00.0-0.0-0.0-0.0
Seeking ratio, punishment vs. effort0.70.90.9-0.9-0.90.9
Run reversals in cocaine runway, females0.20.20.2-0.4-0.40.5
Run reversals in cocaine runway, males1.91.91.91.41.4-1.4
Latency to leave start box in cocaine runway5.76.26.52.52.5-2.5
Latency to leave start box in cocaine runway, F8.59.39.63.03.0-3.1
Latency to leave start box in cocaine runway, M0.10.10.10.30.3-0.4
Cd content in liver0.10.10.1-0.3-0.30.3
Co content in liver0.00.00.00.10.1-0.1
Cu content in liver9.711.712.0-3.4-3.43.5
Fe content in liver1.51.71.9-1.3-1.31.4
K content in liver0.50.50.6-0.7-0.70.8
Mg content in liver2.12.22.4-1.4-1.41.5
Mn content in liver4.04.64.7-2.2-2.22.1
Na content in liver0.50.50.6-0.7-0.70.8
Rb content in liver0.10.10.3-0.3-0.30.5
Se content in liver0.20.20.30.40.4-0.5
Sr content in liver0.80.70.9-0.9-0.90.7
Zn content in liver0.00.00.0-0.0-0.00.1