Hub : Genes

NA

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000069034	0.3400	0.1500	0.0e+00	0.284	0.286	0.285	0.285	1.1e-31	7.1e-32	8.9e-32	8.5e-32
2	Adipose	intron excision ratio	chr7:7856802:7875052	0.0400	0.0298	1.3e-04	0.034	0.024	0.018	0.023	1.1e-04	1.0e-03	4.1e-03	1.2e-03
3	Adipose	intron excision ratio	chr7:7856802:7890874	0.0426	0.0315	7.7e-05	0.036	0.026	0.021	0.027	6.5e-05	6.4e-04	1.9e-03	4.6e-04
4	Adipose	mRNA stability	ENSRNOG00000069034	0.1630	0.0950	2.2e-16	0.138	0.134	0.138	0.137	4.1e-15	1.2e-14	4.9e-15	5.7e-15
5	BLA	gene expression	ENSRNOG00000069034	0.2787	0.1622	1.7e-13	0.240	0.249	0.254	0.249	4.4e-13	1.5e-13	7.4e-14	1.3e-13
6	Brain	gene expression	ENSRNOG00000069034	0.2400	0.1300	0.0e+00	0.192	0.201	0.200	0.203	1.5e-17	2.0e-18	2.9e-18	1.5e-18
7	Brain	intron excision ratio	chr7:7856802:7890874	0.0327	0.0259	1.8e-03	0.024	0.029	0.027	0.027	2.5e-03	1.0e-03	1.4e-03	1.4e-03
8	Brain	mRNA stability	ENSRNOG00000069034	0.0495	0.0385	8.7e-04	0.023	0.035	0.036	0.034	3.2e-03	3.0e-04	2.6e-04	3.9e-04
9	IL	gene expression	ENSRNOG00000069034	0.3100	0.1650	1.6e-05	0.187	0.082	0.139	0.153	3.0e-05	5.2e-03	3.3e-04	1.6e-04
10	LHb	gene expression	ENSRNOG00000069034	0.3078	0.1671	1.3e-05	0.202	0.207	0.177	0.163	1.5e-05	1.2e-05	5.4e-05	1.1e-04
11	Liver	gene expression	ENSRNOG00000069034	0.3100	0.1800	0.0e+00	0.245	0.246	0.240	0.248	5.7e-27	5.3e-27	2.7e-26	2.4e-27
12	Liver	intron excision ratio	chr7:7856802:7875052	0.0451	0.0330	3.0e-05	0.035	0.036	0.035	0.031	7.7e-05	6.8e-05	7.7e-05	1.8e-04
13	Liver	intron excision ratio	chr7:7856802:7890874	0.0572	0.0405	1.9e-06	0.047	0.049	0.044	0.044	5.9e-06	3.7e-06	1.2e-05	1.1e-05
14	NAcc	gene expression	ENSRNOG00000069034	0.2900	0.1400	0.0e+00	0.325	0.324	0.325	0.328	8.4e-25	1.0e-24	8.3e-25	4.6e-25
15	NAcc	intron excision ratio	chr7:7856802:7890874	0.0351	0.0277	2.1e-03	0.035	0.037	0.038	0.037	1.2e-03	8.5e-04	7.1e-04	9.2e-04
16	OFC	gene expression	ENSRNOG00000069034	0.2046	0.1300	1.0e-04	0.168	0.155	0.143	0.169	8.7e-05	1.6e-04	2.9e-04	8.1e-05
17	PL	gene expression	ENSRNOG00000069034	0.3039	0.1421	0.0e+00	0.321	0.327	0.325	0.332	5.7e-25	1.6e-25	2.6e-25	5.6e-26

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Social responses	9.3	12.0	13.4	3.5	3.7	-3.7	3.0	3.6	3.6	-3.5	-3.0	3.5	3.2	3.5	3.5	-3.5	3.6	-3.5	3.3	3.6
Soleus weight	8.3	24.2	29.2	-4.7	-5.0	5.0	-5.2	-5.0	-5.0	5.3	3.2	-5.1	-3.8	-5.0	-5.2	5.1	-5.1	5.2	-5.4	-4.9
Cocaine response after cond. not corrected	7.6	8.5	9.6	-3.1	-3.0	3.0	-2.1	-3.1	-3.1	2.9	2.8	-3.1	-3.0	-3.0	-2.9	3.0	-2.9	2.9	-2.5	-3.0
Conditioned locomotion	7.4	8.9	10.7	2.8	3.0	-3.0	3.2	3.0	3.0	-3.2	-1.9	3.0	2.2	3.1	3.1	-3.1	3.1	-3.2	3.3	3.0
Cocaine response after cond. corrected	7.0	7.8	8.8	-2.9	-2.9	2.9	-2.1	-3.0	-2.9	2.7	2.6	-2.9	-2.9	-2.9	-2.8	2.8	-2.8	2.8	-2.5	-2.9
BMI with tail	6.2	20.1	22.3	-4.3	-4.7	4.7	-4.6	-4.6	-4.6	4.7	3.0	-4.5	-3.5	-4.7	-4.7	4.6	-4.7	4.7	-4.7	-4.6
Seeking ratio, delayed vs. immediate footshock	5.7	6.6	7.4	2.6	2.6	-2.6	2.3	2.6	2.7	-2.6	-1.8	2.7	2.3	2.6	2.7	-2.7	2.6	-2.7	2.5	2.7
Locomotion velocity, session 2	5.6	6.5	7.9	2.8	2.6	-2.6	1.7	2.7	2.7	-2.4	-2.8	2.7	2.8	2.6	2.5	-2.6	2.5	-2.5	2.1	2.7
Locomotion velocity, session 3	5.5	6.3	7.8	2.4	2.6	-2.6	2.8	2.6	2.5	-2.7	-1.5	2.5	1.8	2.6	2.7	-2.6	2.7	-2.7	2.8	2.5
Light reinforcement 1	5.4	9.8	11.4	3.0	3.1	-3.1	3.1	3.2	3.2	-3.3	-2.1	3.3	2.5	3.3	3.3	-3.3	3.2	-3.3	3.4	3.2
Stereotopy head waving duration, day 3	5.4	6.6	7.2	2.5	2.6	-2.6	2.5	2.7	2.6	-2.7	-1.9	2.6	2.2	2.6	2.7	-2.7	2.7	-2.7	2.6	2.6
Extensor digitorum longus weight	5.2	20.8	22.9	-4.6	-4.7	4.7	-3.9	-4.8	-4.7	4.6	3.9	-4.8	-4.3	-4.7	-4.7	4.7	-4.7	4.6	-4.4	-4.7
Stereotopy head waving bouts, day 3	5.0	6.0	6.5	2.5	2.5	-2.5	2.2	2.6	2.5	-2.5	-2.0	2.5	2.2	2.5	2.5	-2.5	2.5	-2.5	2.4	2.5
Intermittent access intake day 1-15 change	4.9	4.9	7.5	2.0	2.2	-2.2	2.7	2.2	2.1	-2.5	-1.0	2.2	1.4	2.3	2.4	-2.3	2.3	-2.4	2.7	2.1
Intermittent access intake escalation 2	4.7	4.7	9.9	1.7	2.2	-2.2	3.2	2.0	2.0	-2.5	-0.3	2.1	0.9	2.1	2.4	-2.3	2.2	-2.4	2.9	2.0
Condit. Reinf. active responses	4.5	5.5	6.3	2.4	2.3	-2.3	2.0	2.5	2.5	-2.3	-2.1	2.4	2.3	2.4	2.4	-2.4	2.4	-2.4	2.1	2.5
Time in familiar zone, hab. session 2	4.3	4.5	8.0	1.8	2.1	-2.1	2.8	2.0	2.1	-2.4	-0.6	2.1	1.1	2.1	2.3	-2.2	2.3	-2.4	2.7	2.1
Locomotor activity	4.2	6.7	8.0	2.7	2.8	-2.8	2.0	2.7	2.7	-2.6	-2.3	2.7	2.5	2.8	2.6	-2.6	2.7	-2.6	2.3	2.7
Condit. Reinf. active minus inactive responses	4.1	4.5	5.1	2.1	2.1	-2.1	2.2	2.2	2.2	-2.2	-1.5	2.2	1.7	2.2	2.2	-2.2	2.3	-2.3	2.2	2.2
Delay disc. indifference point, 0s delay	3.9	4.3	9.7	-1.5	-2.0	2.0	-3.1	-1.8	-1.9	2.4	0.0	-2.0	-0.6	-2.0	-2.3	2.1	-2.2	2.3	-2.8	-1.9
Delay disc. indifference point, 2s delay	3.8	4.3	7.3	-1.7	-2.1	2.1	-2.7	-2.1	-2.0	2.3	0.7	-2.0	-1.0	-2.1	-2.2	2.1	-2.2	2.3	-2.6	-2.0
Breakpoint value in progressive ratio session	3.7	4.1	6.4	1.8	2.1	-2.1	2.5	2.0	2.0	-2.2	-0.8	1.9	1.2	2.1	2.2	-2.1	2.2	-2.2	2.4	2.0
Bone: trabecular tissue density	3.6	5.0	5.8	-2.3	-2.2	2.2	-1.8	-2.4	-2.4	2.2	2.1	-2.4	-2.3	-2.2	-2.3	2.3	-2.3	2.2	-2.0	-2.4
Intermittent access intake escalation	3.3	3.3	8.1	1.4	1.7	-1.7	2.8	1.6	1.6	-2.1	-0.0	1.7	0.6	1.8	2.0	-1.9	1.9	-2.0	2.5	1.6
Active lever presses in extinction session 6	3.2	3.1	3.5	1.7	1.8	-1.8	1.7	1.7	1.8	-1.8	-1.4	1.8	1.5	1.8	1.8	-1.8	1.9	-1.9	1.8	1.8
Mn content in liver	3.2	3.7	8.1	2.2	1.9	-1.9	0.5	2.1	2.0	-1.6	-2.9	1.9	2.6	2.0	1.7	-1.8	1.8	-1.6	1.0	2.0
Mean time between licks in bursts	2.9	4.1	6.0	1.7	2.1	-2.1	2.5	2.0	2.0	-2.2	-0.8	2.0	1.2	2.1	2.1	-2.1	2.2	-2.2	2.4	2.0
Conditioned locomotion	2.9	3.5	4.5	-2.0	-2.0	2.0	-1.1	-2.0	-2.0	1.7	2.1	-2.0	-2.1	-2.0	-1.8	1.8	-1.8	1.8	-1.4	-1.9
Locomotion distance, session 2	2.9	4.1	6.4	2.3	2.0	-2.0	1.0	2.2	2.1	-1.8	-2.5	2.1	2.5	2.1	1.9	-2.0	2.0	-1.9	1.5	2.1
Incentive salience index mean	2.9	3.5	3.9	1.9	1.9	-1.9	1.5	2.0	2.0	-1.8	-1.8	1.9	1.9	1.9	1.9	-1.9	1.9	-1.9	1.7	2.0
Locomotion velocity, hab. session 1	2.9	4.2	6.2	2.3	2.1	-2.1	1.1	2.2	2.1	-1.9	-2.5	2.1	2.4	2.1	1.9	-2.0	2.0	-1.9	1.5	2.1
Conditioned reinforcement - actives	2.8	2.8	3.1	1.6	1.7	-1.7	1.6	1.8	1.7	-1.7	-1.3	1.7	1.4	1.6	1.7	-1.7	1.7	-1.8	1.7	1.7
Short access day 10 total locomotion	2.8	3.0	5.2	1.5	1.7	-1.7	2.3	1.7	1.7	-1.9	-0.7	1.7	0.9	1.9	1.9	-1.8	1.8	-1.9	2.2	1.6
Total locomotion distance, hab. session 1	2.8	4.0	7.6	2.3	2.0	-2.0	0.8	2.2	2.1	-1.7	-2.8	2.1	2.6	2.0	1.8	-1.9	1.9	-1.8	1.3	2.1
Time in novel zone, hab. session 2	2.8	2.8	5.9	-1.3	-1.6	1.6	-2.4	-1.5	-1.6	1.9	0.2	-1.6	-0.6	-1.6	-1.8	1.7	-1.8	1.9	-2.2	-1.6
Bone volume	2.8	4.7	13.4	2.6	2.2	-2.2	-0.2	2.3	2.3	-1.4	-3.7	2.3	3.3	2.2	1.6	-1.8	1.8	-1.6	0.6	2.3
Liver weight, left	2.7	4.4	4.9	-2.1	-2.2	2.2	-1.8	-2.2	-2.1	2.1	1.7	-2.2	-1.9	-2.2	-2.1	2.1	-2.1	2.1	-2.0	-2.1
Bone surface	2.7	4.7	13.5	2.5	2.2	-2.2	-0.2	2.3	2.2	-1.4	-3.7	2.2	3.3	2.2	1.6	-1.8	1.8	-1.6	0.6	2.2
BMI without tail	2.6	5.5	6.9	-2.3	-2.4	2.4	-2.0	-2.4	-2.4	2.4	2.0	-2.4	-2.1	-2.6	-2.4	2.4	-2.4	2.4	-2.2	-2.4
Fecal boli incidents, locomotor time 1	2.5	2.7	3.3	-1.8	-1.7	1.7	-1.0	-1.8	-1.7	1.6	1.6	-1.6	-1.8	-1.7	-1.7	1.7	-1.5	1.6	-1.5	-1.6
Tail length	2.3	7.1	10.7	2.3	2.7	-2.7	3.3	2.6	2.6	-2.9	-1.1	2.7	1.6	2.6	2.9	-2.8	2.8	-2.9	3.2	2.6
Delay discounting water rate 24 sec	2.3	3.2	8.6	-2.1	-1.8	1.8	0.1	-1.9	-1.8	1.2	2.9	-1.9	-2.7	-1.6	-1.4	1.5	-1.5	1.3	-0.6	-1.8
Locomotor testing distance	2.3	3.8	4.6	2.0	2.1	-2.1	1.6	2.0	2.0	-1.9	-1.6	1.9	1.8	2.1	2.0	-2.0	2.0	-2.0	1.8	2.0
Intermittent access day 15 total locomotion	2.2	2.4	4.0	1.3	1.5	-1.5	2.0	1.5	1.5	-1.7	-0.6	1.5	0.8	1.7	1.6	-1.6	1.6	-1.7	1.9	1.5
Intermittent access standard deviation	2.2	2.4	4.0	1.3	1.6	-1.6	2.0	1.5	1.5	-1.7	-0.7	1.5	0.8	1.5	1.7	-1.6	1.6	-1.7	1.9	1.5
Bone: trabecular spacing	2.2	2.9	6.9	-1.9	-1.7	1.7	-0.2	-1.8	-1.8	1.2	2.6	-1.8	-2.4	-1.7	-1.4	1.5	-1.5	1.4	-0.7	-1.8
Bone: trabecular thickness	2.2	2.7	9.7	1.9	1.6	-1.6	-0.6	1.7	1.6	-0.9	-3.1	1.6	2.7	1.6	1.1	-1.3	1.2	-1.0	0.1	1.6
Delta ambulatory time before/after self-admin	2.2	2.3	2.8	1.5	1.6	-1.6	1.3	1.7	1.6	-1.5	-1.3	1.6	1.4	1.6	1.6	-1.6	1.6	-1.5	1.5	1.6
Condit. Reinf. active responses	2.1	2.9	3.7	1.6	1.7	-1.7	1.9	1.7	1.7	-1.8	-0.9	1.8	1.2	1.7	1.8	-1.8	1.8	-1.8	1.9	1.7
Pavlov. Cond. magazine entry latency	2.1	2.7	3.7	1.5	1.7	-1.7	1.9	1.7	1.7	-1.8	-0.9	1.7	1.1	1.7	1.8	-1.7	1.7	-1.8	1.9	1.7
Delta time in closed arm before/after self-admin	2.1	2.1	5.2	-1.6	-1.5	1.5	-0.2	-1.5	-1.5	1.1	2.3	-1.4	-2.0	-1.6	-1.2	1.3	-1.2	1.1	-0.7	-1.5
Delay discounting water rate 12 sec	2.0	2.9	4.0	-1.9	-1.7	1.7	-1.0	-1.8	-2.0	1.5	1.9	-1.8	-2.0	-1.6	-1.6	1.7	-1.8	1.7	-1.2	-2.0
Bone: stiffness	2.0	3.2	5.5	-1.6	-1.8	1.8	-2.3	-1.7	-1.6	2.0	0.6	-1.7	-1.0	-1.8	-2.0	1.9	-1.8	1.9	-2.3	-1.6
Bone: trabecular number	2.0	3.1	4.8	2.0	1.8	-1.8	0.8	1.9	1.9	-1.5	-2.2	1.9	2.2	1.8	1.6	-1.7	1.7	-1.6	1.2	1.9
Total heroin consumption	2.0	2.4	2.8	1.5	1.7	-1.7	1.5	1.6	1.6	-1.6	-1.2	1.5	1.4	1.5	1.6	-1.6	1.6	-1.7	1.5	1.6
Run reversals in cocaine runway, males	2.0	1.9	2.6	1.4	1.5	-1.5	1.1	1.4	1.6	-1.3	-1.2	1.4	1.4	1.3	1.4	-1.4	1.6	-1.5	1.2	1.6
Novel to familiar place preference ratio	1.9	2.0	5.2	-1.0	-1.3	1.3	-2.3	-1.2	-1.3	1.7	-0.1	-1.3	-0.3	-1.3	-1.6	1.5	-1.5	1.6	-2.0	-1.3
Delay discount hyperbolic model param	1.9	2.0	3.2	1.2	1.5	-1.5	1.8	1.4	1.4	-1.6	-0.6	1.4	0.8	1.5	1.5	-1.5	1.5	-1.6	1.7	1.4
Latency to leave start box in cocaine runway	1.9	2.1	3.2	1.6	1.6	-1.6	0.6	1.6	1.5	-1.3	-1.8	1.6	1.8	1.5	1.3	-1.4	1.3	-1.3	0.9	1.5
Condit. Reinf. inactive responses	1.8	2.2	2.6	1.6	1.5	-1.5	1.1	1.5	1.6	-1.5	-1.4	1.6	1.5	1.5	1.5	-1.5	1.5	-1.5	1.3	1.6
Cocaine induced anxiety	1.8	2.0	2.9	1.6	1.6	-1.6	0.7	1.5	1.5	-1.3	-1.6	1.5	1.7	1.3	1.3	-1.4	1.4	-1.3	1.0	1.5
Post-drug Anxiety	1.8	2.0	3.7	1.6	1.6	-1.6	0.4	1.5	1.5	-1.2	-1.9	1.5	1.9	1.2	1.3	-1.3	1.4	-1.2	0.8	1.5
Locomotion velocity, hab. session 2	1.8	2.4	4.2	1.8	1.5	-1.5	0.7	1.7	1.7	-1.4	-2.0	1.7	2.0	1.5	1.5	-1.5	1.5	-1.4	1.1	1.7
Vertical activity count, locomotor time 2	1.8	1.9	2.9	-1.5	-1.4	1.4	-0.7	-1.4	-1.5	1.2	1.7	-1.5	-1.7	-1.3	-1.3	1.3	-1.4	1.3	-0.9	-1.5
Length with tail	1.7	6.4	7.6	2.4	2.7	-2.7	2.6	2.6	2.5	-2.6	-1.7	2.6	2.0	2.8	2.6	-2.6	2.6	-2.7	2.6	2.6
Total zone transitions, hab. session 1	1.7	2.4	3.6	1.7	1.6	-1.6	0.8	1.7	1.6	-1.4	-1.9	1.6	1.9	1.6	1.5	-1.5	1.5	-1.4	1.1	1.6
Right kidney weight	1.6	4.6	5.2	2.1	2.3	-2.3	1.9	2.2	2.2	-2.2	-1.8	2.2	1.9	2.1	2.2	-2.2	2.2	-2.2	2.1	2.2
Light reinforcement 2	1.6	2.1	2.5	1.4	1.5	-1.5	1.5	1.4	1.5	-1.5	-0.9	1.5	1.1	1.6	1.5	-1.5	1.5	-1.5	1.5	1.5
Condit. Reinf. lever presses	1.6	2.2	4.0	1.3	1.4	-1.4	2.0	1.4	1.5	-1.7	-0.3	1.5	0.7	1.4	1.6	-1.6	1.7	-1.7	1.9	1.5
Pavlov. Cond. response bias	1.6	2.2	3.0	1.3	1.5	-1.5	1.7	1.4	1.5	-1.6	-0.6	1.5	1.0	1.4	1.6	-1.5	1.6	-1.6	1.7	1.5
Condit. Reinf. inactive responses	1.6	1.9	2.9	1.6	1.3	-1.3	0.7	1.5	1.5	-1.2	-1.7	1.5	1.7	1.4	1.3	-1.4	1.4	-1.3	1.0	1.5
Time in familiar zone, hab. session 1	1.6	1.5	2.5	1.1	1.2	-1.2	1.6	1.2	1.2	-1.4	-0.4	1.2	0.7	1.2	1.3	-1.3	1.3	-1.3	1.5	1.2
Total locomotion distance, hab. session 2	1.6	2.2	3.1	1.6	1.4	-1.4	0.9	1.6	1.6	-1.4	-1.8	1.6	1.7	1.5	1.4	-1.5	1.4	-1.4	1.1	1.6
Time to tail flick, vehicle, before self-admin	1.6	1.6	3.0	1.5	1.3	-1.3	0.6	0.9	1.4	-1.2	-1.6	1.4	1.7	1.2	1.2	-1.3	1.3	-1.2	0.9	1.4
Time >=10cm from walls, locomotor time 2	1.6	1.7	2.0	-1.3	-1.3	1.3	-1.1	-1.4	-1.4	1.2	1.2	-1.4	-1.2	-1.3	-1.3	1.3	-1.3	1.3	-1.1	-1.4
Liver weight, right	1.5	2.5	3.1	-1.5	-1.6	1.6	-1.8	-1.6	-1.6	1.7	0.9	-1.6	-1.1	-1.6	-1.7	1.6	-1.7	1.7	-1.8	-1.6
Locomotion velocity, session 1	1.5	1.6	2.7	1.4	1.3	-1.3	0.6	1.4	1.3	-1.1	-1.6	1.3	1.6	1.3	1.2	-1.2	1.2	-1.2	0.9	1.3
Locomotion velocity, session 8	1.5	1.8	4.3	1.6	1.4	-1.4	0.2	1.5	1.4	-1.1	-2.1	1.4	1.9	1.4	1.1	-1.2	1.2	-1.1	0.6	1.4
Condit. Reinf. active-inactive response ratio	1.5	1.6	3.0	1.1	1.2	-1.2	1.7	1.2	1.3	-1.4	-0.4	1.2	0.6	1.2	1.4	-1.3	1.4	-1.4	1.6	1.3
Bone: tissue strength	1.5	1.5	2.5	-1.1	-1.1	1.1	-1.6	-1.2	-1.2	1.4	0.5	-1.3	-0.7	-1.1	-1.3	1.3	-1.3	1.3	-1.5	-1.2
Delta distance traveled before/after self-admin	1.5	1.6	2.1	1.2	1.3	-1.3	1.3	1.3	1.3	-1.4	-0.8	1.3	1.0	1.4	1.3	-1.3	1.3	-1.3	1.4	1.3
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.9	-1.5	-1.3	1.3	-0.3	-1.0	-1.3	1.0	1.7	-1.3	-1.7	-1.2	-1.1	1.2	-1.1	1.1	-0.7	-1.3
Latency to leave start box in cocaine runway, M	1.5	1.4	3.2	0.9	1.2	-1.2	1.8	1.2	1.0	-1.4	-0.1	1.2	0.4	1.2	1.4	-1.3	1.2	-1.3	1.6	1.0
Std. dev. time between licks in bursts	1.4	1.7	2.4	1.4	1.3	-1.3	0.7	1.4	1.3	-1.2	-1.5	1.3	1.5	1.4	1.2	-1.3	1.3	-1.2	1.0	1.3
Condit. Reinf. active minus inactive responses	1.4	1.7	3.8	1.0	1.2	-1.2	1.9	1.2	1.2	-1.5	-0.2	1.3	0.5	1.3	1.4	-1.4	1.4	-1.5	1.8	1.2
Condit. Reinf. lever reinforcers received	1.4	2.0	3.2	1.2	1.3	-1.3	1.8	1.4	1.4	-1.6	-0.6	1.5	0.8	1.4	1.5	-1.5	1.5	-1.5	1.7	1.4
Conditioned reinforcement - inactives	1.4	1.6	2.4	-1.4	-1.3	1.3	-0.6	-1.4	-1.4	1.2	1.5	-1.4	-1.6	-1.2	-1.2	1.3	-1.2	1.2	-0.9	-1.4
Area under the delay curve	1.4	1.5	2.5	-1.0	-1.3	1.3	-1.6	-1.2	-1.2	1.4	0.5	-1.2	-0.6	-1.3	-1.3	1.3	-1.3	1.4	-1.5	-1.2
Distance moved, locomotor task time 2	1.4	1.6	2.0	-1.3	-1.3	1.3	-0.9	-1.3	-1.4	1.2	1.3	-1.4	-1.3	-1.2	-1.2	1.2	-1.3	1.3	-1.0	-1.4
Run reversals in cocaine runway, females	1.4	1.4	1.8	1.3	1.1	-1.1	0.8	1.2	1.2	-1.1	-1.3	1.3	1.3	1.1	1.2	-1.2	1.1	-1.1	1.1	1.2
Bone: maximum diameter	1.3	2.4	4.0	1.7	1.7	-1.7	0.6	1.7	1.7	-1.3	-2.0	1.6	1.9	1.7	1.4	-1.5	1.5	-1.4	0.9	1.7
Diff in mean of infusions in LGA sessions	1.3	1.5	2.1	1.1	1.2	-1.2	1.4	1.4	1.2	-1.3	-0.7	1.2	0.9	1.3	1.3	-1.2	1.3	-1.3	1.3	1.2
Delay disc. indifference point, 8s delay	1.3	1.3	1.5	-1.2	-1.2	1.2	-0.9	-1.2	-1.2	1.1	1.0	-1.2	-1.1	-1.2	-1.2	1.2	-1.2	1.2	-1.0	-1.2
Delay discount exponential model param	1.3	1.4	2.2	1.0	1.2	-1.2	1.5	1.2	1.1	-1.3	-0.5	1.2	0.6	1.2	1.2	-1.2	1.2	-1.3	1.4	1.1
Body weight	1.2	5.3	5.7	-2.2	-2.4	2.4	-2.2	-2.4	-2.4	2.4	1.7	-2.4	-1.9	-2.3	-2.4	2.4	-2.4	2.4	-2.4	-2.4
Reaction time number correct	1.2	1.7	2.5	-1.4	-1.4	1.4	-0.6	-1.4	-1.4	1.1	1.6	-1.4	-1.6	-1.3	-1.2	1.2	-1.3	1.2	-0.9	-1.5
Reaction time trials correct on left	1.2	1.7	2.5	-1.4	-1.4	1.4	-0.6	-1.4	-1.4	1.1	1.6	-1.4	-1.6	-1.3	-1.2	1.2	-1.3	1.2	-0.9	-1.5
Reaction time trials on left	1.2	1.6	2.2	-1.4	-1.3	1.3	-0.6	-1.3	-1.4	1.1	1.5	-1.3	-1.5	-1.3	-1.2	1.2	-1.3	1.2	-0.9	-1.4
Reaction time trials completed	1.2	1.6	2.2	-1.4	-1.3	1.3	-0.6	-1.3	-1.4	1.1	1.5	-1.3	-1.5	-1.3	-1.2	1.2	-1.3	1.2	-0.9	-1.4
Reaction time trials AUC	1.2	1.8	2.8	-1.5	-1.4	1.4	-0.6	-1.4	-1.5	1.1	1.7	-1.4	-1.6	-1.3	-1.2	1.3	-1.4	1.2	-0.8	-1.5
Time in novel zone, NPP test	1.2	1.3	3.5	-0.8	-1.0	1.0	-1.9	-1.0	-1.0	1.3	-0.2	-1.0	-0.2	-1.0	-1.2	1.2	-1.2	1.3	-1.6	-1.0
Glucose	1.1	1.7	2.0	-1.3	-1.4	1.4	-1.2	-1.4	-1.3	1.4	1.0	-1.3	-1.1	-1.4	-1.3	1.3	-1.4	1.4	-1.3	-1.3
Pavlov. Cond. magazine entry number	1.1	1.4	1.7	-1.2	-1.3	1.3	-0.9	-1.2	-1.2	1.2	1.0	-1.2	-1.2	-1.2	-1.2	1.2	-1.2	1.2	-1.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.7	1.2	1.3	-1.3	1.1	1.2	1.2	-1.2	-0.8	1.2	1.0	1.2	1.2	-1.2	1.3	-1.2	1.2	1.2
Bone: cortical apparent density	1.1	1.4	1.9	-1.2	-1.1	1.1	-1.3	-1.2	-1.2	1.3	0.8	-1.3	-1.0	-1.1	-1.3	1.3	-1.2	1.2	-1.4	-1.2
Distance traveled after self-admin	1.1	1.3	1.9	1.1	1.1	-1.1	1.0	1.4	1.1	-1.2	-0.8	1.3	1.0	1.1	1.2	-1.2	1.2	-1.1	1.1	1.1
Delta time in open arm before/after self-admin	1.1	1.0	1.7	-0.9	-1.0	1.0	-1.3	-0.8	-1.0	1.1	0.4	-1.0	-0.7	-0.9	-1.1	1.1	-1.1	1.1	-1.3	-1.0
Change in fecal boli incidents, locomotor task	1.1	1.0	2.3	1.2	1.1	-1.1	0.1	1.2	1.0	-0.8	-1.5	0.9	1.4	1.0	0.9	-0.9	0.8	-0.8	0.6	1.0
Reaction time mean minus median	1.0	1.2	1.6	1.1	1.3	-1.3	1.0	1.2	1.2	-1.1	-0.8	1.0	1.0	1.0	1.1	-1.1	1.2	-1.2	0.9	1.2
Pavlov. Cond. lever latency	1.0	1.3	1.5	-1.1	-1.2	1.2	-1.1	-1.2	-1.2	1.2	0.7	-1.2	-1.0	-1.1	-1.2	1.2	-1.2	1.2	-1.2	-1.2
Pavlov. Cond. index score	1.0	1.3	1.5	1.1	1.2	-1.2	1.1	1.1	1.1	-1.2	-0.6	1.1	0.9	1.1	1.2	-1.2	1.2	-1.2	1.2	1.2
Pavlov. Cond. latency score	1.0	1.3	1.5	1.1	1.2	-1.2	1.0	1.2	1.2	-1.2	-0.8	1.2	1.0	1.2	1.2	-1.2	1.2	-1.2	1.1	1.2
Locomotion velocity, session 7	1.0	1.1	1.2	1.1	1.0	-1.0	0.9	1.1	1.1	-1.0	-1.0	1.1	1.0	1.1	1.1	-1.1	1.1	-1.0	1.0	1.1
Novelty place preference	1.0	1.0	3.1	-0.6	-0.9	0.9	-1.8	-0.8	-0.9	1.2	-0.3	-0.9	-0.0	-0.9	-1.1	1.0	-1.1	1.2	-1.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.6	1.2	1.2	-1.2	0.8	1.2	1.2	-1.1	-1.2	1.2	1.2	1.2	1.1	-1.1	1.1	-1.1	0.9	1.2
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	1.1	-1.1	1.1	1.1	1.1	-1.2	-0.8	1.1	0.9	1.1	1.2	-1.1	1.2	-1.2	1.2	1.1
Bouts of movement, locomotor time 2	1.0	1.0	2.2	1.1	1.0	-1.0	0.4	1.2	1.1	-0.9	-1.5	1.0	1.3	1.1	0.9	-1.0	1.0	-0.9	0.6	1.1
Total resting periods, locomotor time 2	1.0	1.1	2.5	1.2	1.0	-1.0	0.4	1.2	1.1	-0.8	-1.6	1.1	1.4	1.1	0.9	-1.0	1.0	-0.9	0.5	1.1
Rest time, locomotor task time 2	1.0	1.1	1.5	1.1	1.1	-1.1	0.6	1.1	1.2	-0.9	-1.2	1.1	1.2	1.1	1.0	-1.0	1.1	-1.1	0.7	1.2
Indifference point AUC	0.9	1.1	1.4	1.0	1.0	-1.0	1.1	1.1	1.1	-1.1	-0.6	1.1	0.7	1.0	1.1	-1.1	1.1	-1.1	1.2	1.1
Social response proportion	0.9	1.0	1.2	1.0	1.0	-1.0	0.8	1.1	1.1	-1.0	-1.1	1.0	1.0	1.0	1.0	-1.0	1.0	-1.0	0.9	1.1
Social time	0.9	1.2	1.4	-1.1	-1.1	1.1	-1.0	-1.2	-1.2	1.1	0.9	-1.2	-1.0	-1.1	-1.1	1.1	-1.2	1.1	-1.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.5	-1.1	-1.2	1.2	-0.6	-1.1	-1.1	1.0	1.2	-1.1	-1.2	-1.1	-1.0	1.0	-1.1	1.0	-0.8	-1.1
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.2	0.9	1.1	-1.1	1.1	1.0	1.0	-1.0	-0.6	1.0	0.7	1.0	1.0	-1.0	1.0	-1.1	1.1	0.9
Short access day 1 locomotion	0.9	0.9	1.8	0.9	1.3	-1.3	0.7	0.9	0.9	-0.9	-0.9	0.9	0.9	1.2	0.9	-0.9	0.9	-0.9	0.8	0.9
Short access total locomotion	0.9	0.9	1.6	0.9	1.2	-1.2	0.8	0.9	0.9	-0.9	-0.8	1.0	0.8	1.1	1.0	-1.0	1.0	-1.0	0.9	0.9
Degree of sensitization stereotypy	0.9	1.0	2.7	-0.7	-0.9	0.9	-1.6	-0.9	-0.9	1.2	-0.1	-0.9	-0.2	-0.9	-1.1	1.0	-1.1	1.1	-1.4	-0.9
Pavlov. Cond. latency score	0.9	1.1	2.1	1.2	1.1	-1.1	0.4	1.1	1.1	-0.9	-1.4	1.1	1.4	1.1	0.9	-1.0	1.0	-0.9	0.6	1.1
Bone: apparent density	0.9	1.5	5.6	1.5	1.1	-1.1	-0.5	1.3	1.2	-0.7	-2.4	1.2	2.1	1.2	0.8	-0.9	0.9	-0.7	0.1	1.2
Bone: cortical porosity	0.9	0.9	1.2	1.0	1.0	-1.0	0.6	1.0	1.0	-0.9	-1.1	1.0	1.0	1.0	0.9	-0.9	1.0	-0.9	0.8	1.0
Time in open arm before self-admin	0.9	0.9	1.6	0.8	0.9	-0.9	1.3	0.9	1.0	-1.1	-0.4	1.0	0.5	0.9	1.1	-1.0	1.0	-1.1	1.3	1.0
Time in open arm after self-admin	0.9	1.0	1.4	-1.1	-1.0	1.0	-0.9	-0.9	-1.1	1.1	0.7	-1.2	-1.0	-0.9	-1.1	1.1	-1.1	1.0	-1.1	-1.1
Time to tail flick, test, before self-admin	0.9	0.9	2.6	1.1	1.1	-1.1	0.1	0.7	1.0	-0.7	-1.6	0.9	1.4	0.9	0.8	-0.9	0.9	-0.8	0.4	1.0
Tibialis anterior weight	0.8	2.8	3.4	-1.6	-1.7	1.7	-1.8	-1.7	-1.7	1.8	1.1	-1.7	-1.3	-1.7	-1.8	1.7	-1.8	1.8	-1.8	-1.7
Delay discounting total patch changes 18 sec	0.8	1.0	1.3	1.0	1.1	-1.1	1.0	1.0	1.0	-1.1	-0.6	1.1	0.8	1.0	1.1	-1.1	1.1	-1.1	1.1	1.0
Delay discounting time to switch 0 sec	0.8	1.2	2.9	-0.8	-1.1	1.1	-1.7	-1.0	-0.9	1.3	-0.0	-1.0	-0.2	-1.1	-1.2	1.1	-1.1	1.2	-1.5	-0.9
Pavlov. Cond. change in total contacts	0.8	1.2	1.5	1.0	1.1	-1.1	1.2	1.1	1.1	-1.2	-0.5	1.1	0.8	1.0	1.2	-1.1	1.2	-1.2	1.2	1.1
Intermittent access day 15 total infusions	0.8	0.9	2.2	0.7	0.9	-0.9	1.5	0.8	0.9	-1.1	-0.1	0.9	0.3	1.0	1.1	-1.0	1.0	-1.1	1.3	0.9
Locomotion distance, session 1	0.8	1.0	2.9	1.2	0.9	-0.9	-0.0	1.1	1.0	-0.7	-1.7	1.0	1.6	1.0	0.8	-0.9	0.8	-0.7	0.3	1.0
Bone: cortical tissue density	0.8	1.1	1.4	-1.0	-0.9	0.9	-1.1	-1.1	-1.1	1.1	0.7	-1.1	-0.9	-1.0	-1.1	1.1	-1.1	1.1	-1.2	-1.1
Latency to leave start box in cocaine runway, F	0.8	0.9	3.2	1.1	1.0	-1.0	-0.5	0.9	0.9	-0.4	-1.8	0.9	1.6	0.8	0.6	-0.7	0.6	-0.6	-0.1	0.9
Zn content in liver	0.8	0.9	3.5	0.4	0.6	-0.6	1.9	0.6	0.6	-1.1	0.7	0.6	-0.3	0.7	1.0	-0.9	0.9	-1.0	1.6	0.7
Retroperitoneal fat weight	0.7	2.5	3.0	-1.7	-1.5	1.5	-1.1	-1.7	-1.7	1.6	1.6	-1.7	-1.6	-1.4	-1.6	1.6	-1.6	1.5	-1.4	-1.7
Tibia length	0.7	1.9	2.9	1.2	1.5	-1.5	1.7	1.4	1.3	-1.5	-0.7	1.4	0.8	1.5	1.5	-1.4	1.4	-1.5	1.6	1.3
Delay discounting water rate 18 sec	0.7	0.9	4.3	-1.1	-0.8	0.8	0.9	-0.8	-0.8	0.3	2.1	-0.8	-1.7	-0.8	-0.4	0.5	-0.5	0.4	0.3	-0.8
Cocaine response before conditioning	0.7	0.8	1.0	0.9	1.0	-1.0	0.7	0.9	0.9	-0.9	-0.7	0.9	0.9	0.9	0.9	-0.9	0.9	-0.9	0.8	0.9
Pavlov. Cond. magazine entry latency	0.7	0.8	1.1	0.9	1.0	-1.0	0.6	0.9	0.9	-0.9	-0.8	0.9	0.9	1.0	0.9	-0.9	0.9	-0.9	0.7	0.9
Pavlov. Cond. lever contacts	0.7	0.9	1.3	0.9	0.9	-0.9	1.2	0.9	1.0	-1.1	-0.3	1.0	0.6	0.9	1.0	-1.0	1.1	-1.1	1.1	1.0
Intermittent access total locomotion	0.7	0.8	1.1	0.8	1.0	-1.0	1.0	0.8	0.9	-1.0	-0.5	0.9	0.6	1.0	0.9	-0.9	0.9	-1.0	1.0	0.9
Stereotopy head waving duration, day 7	0.7	0.9	2.4	1.1	1.0	-1.0	0.0	1.0	0.9	-0.7	-1.5	0.9	1.4	1.0	0.8	-0.8	0.8	-0.7	0.3	0.9
Condit. Reinf. lever presses	0.7	1.0	3.4	1.2	0.9	-0.9	-0.2	1.0	1.0	-0.6	-1.9	0.9	1.6	0.9	0.7	-0.8	0.8	-0.7	0.1	1.0
Pavlov. Cond. index score	0.7	0.9	1.3	1.0	0.9	-0.9	0.5	1.0	1.0	-0.8	-1.1	1.0	1.1	1.0	0.9	-0.9	0.9	-0.9	0.7	1.0
Bone: cortical thickness	0.7	1.1	2.3	-0.9	-1.0	1.0	-1.5	-1.0	-0.9	1.3	0.2	-1.1	-0.5	-1.0	-1.2	1.1	-1.1	1.1	-1.5	-0.9
Reaction time mean minus median AUC	0.6	0.7	2.2	1.0	1.0	-1.0	-0.2	0.9	0.9	-0.5	-1.5	0.7	1.4	0.7	0.6	-0.6	0.7	-0.6	-0.0	0.9
Std. dev. reaction times	0.6	0.8	1.2	1.0	1.0	-1.0	0.4	1.0	1.0	-0.8	-1.0	0.8	1.1	0.8	0.8	-0.8	0.9	-0.9	0.5	1.0
Compulsive drug intake	0.6	0.6	0.9	-0.6	-0.8	0.8	-1.0	-0.7	-0.7	0.8	0.4	-0.7	-0.4	-0.8	-0.8	0.8	-0.8	0.9	-0.9	-0.7
Pavlov. Cond. lever contacts	0.6	0.7	2.3	1.0	0.8	-0.8	-0.1	0.9	0.8	-0.6	-1.5	0.8	1.3	0.8	0.6	-0.7	0.7	-0.6	0.2	0.8
Bone: endosteal perimeter	0.6	1.3	2.6	1.3	1.2	-1.2	0.3	1.2	1.2	-0.9	-1.6	1.1	1.5	1.2	1.0	-1.0	1.0	-1.0	0.6	1.2
Bone: maximum force	0.6	1.0	2.8	-0.7	-0.9	0.9	-1.7	-0.9	-0.8	1.2	-0.1	-0.9	-0.2	-0.9	-1.2	1.1	-1.0	1.1	-1.5	-0.8
Bone: post-yield work	0.6	0.8	1.1	-0.9	-0.9	0.9	-0.9	-1.0	-0.9	1.0	0.6	-0.9	-0.7	-0.9	-1.0	1.0	-0.9	0.9	-1.0	-0.9
Ambulatory time after self-admin	0.6	0.7	1.1	0.8	0.8	-0.8	0.7	1.1	0.8	-0.8	-0.6	1.0	0.7	0.9	0.8	-0.8	0.9	-0.8	0.8	0.8
Locomotion in novel chamber post-restriction	0.6	0.8	0.9	0.9	0.9	-0.9	0.8	0.9	0.9	-0.9	-0.5	0.9	0.8	0.8	0.9	-0.9	0.9	-1.0	1.0	0.9
Number of licking bursts	0.5	0.6	1.5	-0.9	-0.8	0.8	-0.0	-0.8	-0.8	0.6	1.2	-0.8	-1.2	-0.7	-0.6	0.7	-0.7	0.6	-0.3	-0.8
Food consumed during 24 hour testing period	0.5	0.6	0.7	-0.7	-0.8	0.8	-0.8	-0.8	-0.8	0.8	0.5	-0.7	-0.6	-0.8	-0.8	0.8	-0.8	0.8	-0.8	-0.8
Delay discounting total patch changes 12 sec	0.5	0.7	1.1	-0.9	-1.0	1.0	-0.3	-0.9	-0.8	0.7	1.1	-0.9	-1.0	-1.0	-0.8	0.8	-0.7	0.7	-0.6	-0.8
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	-0.8	-0.8	0.8	-0.8	-0.8	-0.8	0.9	0.6	-0.8	-0.7	-0.8	-0.9	0.9	-0.8	0.9	-0.9	-0.8
Bone: maximum moment	0.5	0.9	2.4	-0.7	-0.8	0.8	-1.6	-0.8	-0.7	1.1	-0.2	-0.9	-0.2	-0.8	-1.1	1.0	-0.9	1.0	-1.4	-0.7
Bone: periosteal perimeter	0.5	0.8	2.6	1.0	1.0	-1.0	-0.2	1.0	0.9	-0.5	-1.6	0.8	1.4	1.0	0.6	-0.7	0.8	-0.7	0.1	0.9
Extinction: sum of active levers before priming	0.5	0.5	1.7	0.3	0.6	-0.6	1.3	0.7	0.5	-0.8	0.3	0.6	-0.1	0.6	0.7	-0.7	0.8	-0.8	1.1	0.5
Time to tail flick, test, after self-admin	0.5	0.5	1.1	0.9	0.9	-0.9	0.3	0.6	0.8	-0.6	-1.1	0.7	1.0	0.7	0.7	-0.7	0.6	-0.7	0.5	0.7
Weight adjusted by age	0.5	0.5	0.8	-0.8	-0.7	0.7	-0.4	-0.7	-0.7	0.7	0.8	-0.8	-0.9	-0.9	-0.7	0.7	-0.7	0.6	-0.6	-0.8
Na content in liver	0.5	0.5	1.4	-0.5	-0.7	0.7	-1.2	-0.7	-0.7	0.9	-0.1	-0.7	-0.2	-0.6	-0.8	0.8	-0.8	0.8	-1.1	-0.7
Times rat made contact with spout	0.4	0.5	0.8	-0.8	-0.8	0.8	-0.2	-0.7	-0.7	0.6	0.9	-0.6	-0.9	-0.7	-0.6	0.6	-0.6	0.6	-0.4	-0.7
Reaction time premature initiation rate	0.4	0.5	1.7	0.4	0.5	-0.5	1.3	0.6	0.6	-0.8	0.3	0.5	-0.1	0.7	0.8	-0.7	0.8	-0.8	1.1	0.6
Short access day 1 total infusions	0.4	0.5	1.0	0.8	0.9	-0.9	-0.0	0.7	0.7	-0.5	-1.0	0.7	1.0	0.6	0.5	-0.6	0.6	-0.5	0.2	0.7
Context. condit. distance diff. score	0.4	0.5	0.5	-0.7	-0.6	0.6	-0.7	-0.7	-0.7	0.7	0.5	-0.7	-0.6	-0.7	-0.7	0.7	-0.7	0.7	-0.7	-0.7
Degree of sensitization distance	0.4	0.4	0.5	-0.6	-0.6	0.6	-0.7	-0.6	-0.6	0.6	0.4	-0.6	-0.4	-0.6	-0.6	0.6	-0.6	0.6	-0.7	-0.6
Time in novel zone, hab. session 1	0.4	0.4	1.5	-0.2	-0.5	0.5	-1.2	-0.4	-0.5	0.7	-0.5	-0.5	0.2	-0.5	-0.6	0.6	-0.6	0.7	-1.0	-0.5
Bone: final force	0.4	0.7	2.5	-0.5	-0.7	0.7	-1.6	-0.7	-0.6	1.0	-0.4	-0.7	0.1	-0.7	-1.0	0.9	-0.8	0.9	-1.4	-0.6
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	-0.5	-0.7	0.7	-0.7	-0.6	-0.6	0.6	0.5	-0.6	-0.4	-0.7	-0.6	0.6	-0.6	0.6	-0.7	-0.6
Delay disc. indifference point, 4s delay	0.4	0.4	1.5	-0.3	-0.6	0.6	-1.2	-0.5	-0.5	0.7	-0.4	-0.5	0.2	-0.6	-0.7	0.6	-0.6	0.7	-1.0	-0.5
Locomotion in novel chamber	0.4	0.4	0.7	0.6	0.5	-0.5	0.8	0.6	0.7	-0.8	-0.1	0.7	0.4	0.5	0.8	-0.7	0.8	-0.8	0.9	0.7
Mg content in liver	0.4	0.4	1.7	0.8	0.6	-0.6	-0.2	0.7	0.6	-0.4	-1.3	0.6	1.1	0.6	0.5	-0.5	0.5	-0.4	0.0	0.6
Parametrial fat weight	0.3	0.5	1.0	0.6	0.8	-0.8	1.0	0.7	0.7	-0.8	-0.1	0.7	0.3	0.8	0.8	-0.7	0.8	-0.8	0.9	0.7
Indifference point function ln k	0.3	0.4	0.6	-0.7	-0.7	0.7	-0.6	-0.7	-0.7	0.7	0.5	-0.8	-0.6	-0.5	-0.7	0.7	-0.7	0.7	-0.7	-0.7
Indifference point function log k	0.3	0.4	0.6	-0.7	-0.7	0.7	-0.6	-0.7	-0.7	0.7	0.5	-0.8	-0.6	-0.5	-0.7	0.7	-0.7	0.7	-0.7	-0.7
Reaction time omissions	0.3	0.4	0.6	0.7	0.8	-0.8	0.4	0.7	0.7	-0.6	-0.6	0.7	0.7	0.6	0.6	-0.6	0.7	-0.7	0.5	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.4	-0.6	-0.4	0.4	0.7	-0.4	-0.4	0.0	1.2	-0.4	-1.0	-0.4	-0.1	0.2	-0.2	0.1	0.4	-0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.5	0.4	-0.4	0.8	0.6	0.6	-0.6	-0.3	0.6	0.3	0.4	0.6	-0.6	0.6	-0.7	0.7	0.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.7	-0.5	0.5	-0.3	-0.7	-0.7	0.6	0.7	-0.7	-0.7	-0.6	-0.6	0.6	-0.5	0.5	-0.5	-0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.6	-0.5	0.5	-0.5	-0.7	-0.7	0.6	0.6	-0.7	-0.6	-0.6	-0.6	0.6	-0.5	0.6	-0.5	-0.6
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	0.5	0.6	-0.6	0.6	0.6	0.6	-0.6	-0.5	0.6	0.4	0.5	0.6	-0.6	0.6	-0.6	0.6	0.6
Total sessions with >9 infusions	0.3	0.3	0.9	0.6	0.7	-0.7	-0.2	0.5	0.5	-0.3	-1.0	0.5	0.8	0.4	0.3	-0.4	0.4	-0.3	0.0	0.5
One hour access (0.3 mA shock)	0.3	0.4	0.5	-0.6	-0.6	0.6	-0.5	-0.7	-0.7	0.6	0.5	-0.7	-0.6	-0.6	-0.6	0.7	-0.6	0.6	-0.6	-0.7
Stereotopy head waving bouts, day 7	0.3	0.3	1.4	0.7	0.6	-0.6	-0.3	0.6	0.5	-0.3	-1.2	0.5	1.0	0.6	0.4	-0.4	0.4	-0.3	-0.0	0.5
Locomotion velocity, NPP test	0.3	0.5	1.6	0.9	0.6	-0.6	-0.0	0.7	0.7	-0.5	-1.3	0.7	1.1	0.6	0.6	-0.6	0.6	-0.5	0.2	0.7
Bone: connectivity density	0.3	0.5	2.6	0.8	0.5	-0.5	-0.8	0.6	0.5	-0.1	-1.6	0.6	1.3	0.5	0.2	-0.3	0.3	-0.2	-0.4	0.5
Bone: cortical porosity	0.3	0.4	1.2	0.7	0.6	-0.6	-0.1	0.7	0.6	-0.4	-1.1	0.6	1.0	0.6	0.4	-0.5	0.5	-0.4	0.1	0.6
Bone: elastic displacement	0.3	0.4	0.4	0.6	0.6	-0.6	0.5	0.6	0.6	-0.6	-0.5	0.5	0.5	0.6	0.6	-0.6	0.6	-0.6	0.6	0.6
Bone: final moment	0.3	0.6	2.1	-0.4	-0.6	0.6	-1.4	-0.6	-0.5	0.9	-0.4	-0.6	0.1	-0.6	-0.8	0.8	-0.7	0.8	-1.3	-0.5
Time in closed arm before self-admin	0.3	0.4	1.4	-0.3	-0.5	0.5	-1.2	-0.6	-0.4	0.7	-0.4	-0.5	0.1	-0.3	-0.7	0.6	-0.7	0.7	-1.0	-0.5
Rest time, locomotor task time 1	0.3	0.3	0.4	0.5	0.6	-0.6	0.3	0.6	0.6	-0.5	-0.5	0.6	0.6	0.6	0.5	-0.5	0.5	-0.5	0.3	0.6
Co content in liver	0.3	0.4	0.9	0.4	0.6	-0.6	0.9	0.5	0.5	-0.7	0.1	0.5	0.1	0.6	0.7	-0.6	0.7	-0.7	0.9	0.5
K content in liver	0.3	0.3	1.1	0.7	0.5	-0.5	-0.2	0.6	0.5	-0.3	-1.0	0.5	0.9	0.5	0.4	-0.4	0.4	-0.3	0.0	0.5
Se content in liver	0.3	0.3	0.4	0.6	0.5	-0.5	0.4	0.6	0.6	-0.6	-0.6	0.6	0.6	0.6	0.6	-0.6	0.6	-0.5	0.6	0.6
Sr content in liver	0.3	0.3	1.2	-0.6	-0.5	0.5	0.3	-0.5	-0.5	0.2	1.1	-0.5	-0.9	-0.5	-0.3	0.4	-0.3	0.3	0.1	-0.5
Heart weight	0.2	0.2	0.7	0.3	0.5	-0.5	0.8	0.4	0.3	-0.6	0.1	0.4	-0.0	0.4	0.5	-0.5	0.4	-0.5	0.8	0.3
Left kidney weight	0.2	0.6	1.6	0.9	0.8	-0.8	-0.0	0.9	0.8	-0.6	-1.3	0.9	1.2	0.6	0.6	-0.7	0.7	-0.6	0.3	0.8
Length without tail	0.2	0.4	1.2	0.8	0.7	-0.7	0.0	0.7	0.7	-0.5	-1.1	0.6	1.0	0.9	0.5	-0.6	0.6	-0.5	0.2	0.7
Intraocular pressure	0.2	0.2	1.4	-0.5	-0.5	0.5	0.6	-0.4	-0.3	0.1	1.2	-0.3	-0.9	-0.5	-0.1	0.2	-0.1	0.1	0.3	-0.3
Water consumed over 24 hours	0.2	0.2	1.0	-0.1	-0.3	0.3	-1.0	-0.2	-0.3	0.5	-0.5	-0.2	0.3	-0.3	-0.4	0.4	-0.4	0.5	-0.7	-0.3
Delay discounting water rate 0 sec	0.2	0.3	1.2	-0.6	-0.4	0.4	0.6	-0.4	-0.4	0.1	1.1	-0.5	-1.0	-0.3	-0.2	0.3	-0.3	0.2	0.1	-0.4
Delay discounting water rate 6 sec	0.2	0.3	1.4	-0.3	-0.1	0.1	1.0	-0.1	-0.2	-0.3	1.2	-0.0	-0.9	-0.1	0.2	-0.1	0.0	-0.1	0.8	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.6	-0.7	-0.6	0.6	-0.1	-0.6	-0.6	0.5	0.8	-0.5	-0.8	-0.7	-0.5	0.5	-0.5	0.5	-0.3	-0.6
Reaction time mean	0.2	0.3	1.0	0.6	0.6	-0.6	-0.3	0.5	0.6	-0.2	-1.0	0.4	1.0	0.4	0.3	-0.4	0.4	-0.4	-0.1	0.6
Reaction time premature initiations	0.2	0.3	1.3	-0.3	-0.2	0.2	1.1	-0.1	-0.1	-0.3	1.1	-0.1	-0.9	0.1	0.2	-0.1	0.2	-0.2	0.7	-0.1
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.9	0.1	0.3	-0.3	0.9	0.3	0.3	-0.5	0.4	0.3	-0.2	0.4	0.4	-0.4	0.4	-0.5	0.7	0.3
Intermitt. access escalation Index	0.2	0.2	1.0	0.4	0.4	-0.4	-0.8	0.3	0.2	0.1	-1.0	0.2	0.8	0.2	-0.0	-0.1	0.1	0.0	-0.4	0.2
Incentive Sensitization - Responses	0.2	0.2	0.5	0.3	0.2	-0.2	0.7	0.4	0.4	-0.5	-0.0	0.4	0.1	0.3	0.5	-0.5	0.5	-0.5	0.6	0.4
Number of responses in last shaping day	0.2	0.2	0.3	0.4	0.6	-0.6	0.3	0.4	0.4	-0.4	-0.3	0.4	0.4	0.4	0.4	-0.4	0.4	-0.4	0.4	0.4
Locomotion distance, session 7	0.2	0.3	0.6	-0.6	-0.5	0.5	-0.0	-0.5	-0.5	0.4	0.8	-0.5	-0.8	-0.5	-0.4	0.5	-0.4	0.4	-0.2	-0.5
Locomotion distance, session 8	0.2	0.3	0.6	0.6	0.5	-0.5	0.2	0.6	0.6	-0.4	-0.8	0.6	0.7	0.5	0.5	-0.5	0.5	-0.5	0.3	0.6
Total zone transitions, hab. session 2	0.2	0.3	1.9	0.6	0.2	-0.2	-0.7	0.4	0.4	-0.0	-1.4	0.4	1.1	0.3	0.1	-0.2	0.1	-0.0	-0.4	0.4
Total locomotion distance, NPP test	0.2	0.3	1.3	0.6	0.3	-0.3	-0.3	0.5	0.5	-0.2	-1.1	0.5	1.0	0.4	0.3	-0.4	0.3	-0.2	-0.1	0.5
Pavlov. Cond. lever latency	0.2	0.3	1.3	-0.6	-0.5	0.5	0.3	-0.5	-0.5	0.2	1.1	-0.5	-1.0	-0.5	-0.3	0.4	-0.3	0.3	0.0	-0.5
Bone: cortical area	0.2	0.3	1.4	0.0	-0.2	0.2	-1.2	-0.1	-0.1	0.6	-0.8	-0.2	0.5	-0.2	-0.5	0.4	-0.3	0.4	-1.0	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.4	0.4	0.6	-0.6	0.6	0.5	0.5	-0.5	-0.4	0.5	0.4	0.6	0.5	-0.5	0.6	-0.6	0.4	0.6
Progressive ratio	0.2	0.3	0.5	-0.6	-0.7	0.7	-0.2	-0.5	-0.5	0.5	0.5	-0.5	-0.6	-0.7	-0.5	0.5	-0.4	0.5	-0.3	-0.5
Epididymis fat weight	0.1	0.1	0.7	0.1	0.2	-0.2	0.8	0.3	0.3	-0.4	0.3	0.2	-0.1	0.1	0.4	-0.3	0.4	-0.5	0.6	0.3
Indifference point 0 sec	0.1	0.2	0.3	-0.4	-0.5	0.5	-0.5	-0.5	-0.4	0.5	0.2	-0.5	-0.3	-0.4	-0.5	0.5	-0.4	0.4	-0.6	-0.4
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	-0.4	-0.5	0.5	-0.4	-0.5	-0.4	0.5	0.3	-0.5	-0.4	-0.4	-0.5	0.5	-0.4	0.4	-0.5	-0.4
Delay discounting total patch changes 24 sec	0.1	0.2	0.3	0.5	0.4	-0.4	0.2	0.4	0.4	-0.4	-0.3	0.5	0.5	0.2	0.4	-0.5	0.4	-0.4	0.4	0.4
Delay discounting total patch changes 6 sec	0.1	0.2	0.4	0.4	0.3	-0.3	0.6	0.4	0.5	-0.4	-0.2	0.4	0.2	0.5	0.4	-0.4	0.6	-0.5	0.4	0.6
Reaction time num false alarms	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.1	-0.3	-0.3	0.2	0.4	-0.2	-0.4	-0.4	-0.3	0.3	-0.2	0.3	-0.1	-0.3
Reaction time mean AUC	0.1	0.2	0.8	0.5	0.5	-0.5	-0.4	0.4	0.4	-0.1	-0.9	0.3	0.8	0.3	0.2	-0.2	0.3	-0.2	-0.3	0.4
Median of all reaction times	0.1	0.1	0.8	0.1	0.0	-0.0	-0.9	-0.0	-0.0	0.3	-0.6	-0.1	0.5	-0.1	-0.3	0.2	-0.2	0.3	-0.7	-0.0
Saline control response	0.1	0.2	0.4	-0.4	-0.5	0.5	-0.1	-0.4	-0.4	0.3	0.6	-0.3	-0.5	-0.4	-0.3	0.4	-0.3	0.3	-0.2	-0.4
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.6	0.2	0.4	-0.4	0.7	0.3	0.3	-0.4	0.0	0.2	-0.1	0.5	0.4	-0.3	0.5	-0.5	0.6	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.4	-0.3	-0.3	0.3	0.1	-0.3	-0.1	-0.2	-0.3	0.3	-0.2	0.3	-0.4	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.1	0.3	-0.3	0.5	0.2	0.2	-0.3	0.1	0.2	-0.0	0.4	0.3	-0.3	0.4	-0.4	0.4	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.1	0.2	-0.2	0.6	0.2	0.2	-0.3	0.1	0.2	-0.1	0.2	0.3	-0.3	0.3	-0.3	0.4	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	0.3	-0.3	0.2	0.3	0.3	-0.2	-0.3	0.2	0.3	0.3	0.2	-0.2	0.3	-0.3	0.2	0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.3	0.0	-0.0	0.4	-0.2	-0.2	-0.0	0.6	-0.2	-0.5	-0.0	-0.0	0.1	-0.0	0.0	0.2	-0.2
Short access total infusions	0.1	0.1	0.4	0.4	0.5	-0.5	-0.2	0.3	0.3	-0.1	-0.6	0.3	0.5	0.2	0.2	-0.2	0.3	-0.2	-0.1	0.3
One hour access (shock baseline)	0.1	0.1	0.3	-0.4	-0.2	0.2	0.2	-0.3	-0.3	0.1	0.5	-0.3	-0.6	-0.2	-0.2	0.2	-0.2	0.1	0.0	-0.3
Total zone transitions, NPP test	0.1	0.1	0.6	0.4	0.2	-0.2	-0.2	0.3	0.3	-0.1	-0.8	0.3	0.7	0.2	0.2	-0.2	0.2	-0.1	-0.0	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.3	0.3	-0.3	-0.3	0.3	0.3	0.3	0.3	-0.3	0.3	-0.3	0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	-0.3	-0.2	0.2	0.6	-0.2	-0.0	-0.1	0.7	-0.1	-0.5	-0.1	0.0	0.0	0.1	-0.1	0.3	-0.0
Bone: cortical thickness	0.1	0.1	0.5	-0.4	-0.3	0.3	0.3	-0.3	-0.2	0.1	0.7	-0.3	-0.6	-0.3	-0.1	0.2	-0.1	0.1	0.1	-0.2
Bone: elastic work	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.5	-0.1	-0.1	0.3	-0.3	-0.2	0.2	-0.1	-0.3	0.2	-0.2	0.2	-0.5	-0.1
Bone: endosteal estimation	0.1	0.2	0.8	-0.1	-0.2	0.2	-0.9	-0.2	-0.3	0.5	-0.4	-0.3	0.2	-0.2	-0.4	0.4	-0.4	0.4	-0.7	-0.2
Bone: marrow area	0.1	0.2	0.9	-0.2	-0.2	0.2	-0.9	-0.3	-0.3	0.5	-0.4	-0.3	0.1	-0.2	-0.5	0.4	-0.4	0.5	-0.7	-0.3
Bone: minimum diameter	0.1	0.2	0.9	0.5	0.4	-0.4	-0.3	0.4	0.4	-0.1	-1.0	0.3	0.8	0.4	0.2	-0.2	0.3	-0.2	-0.2	0.4
Bone: periosteal estimation	0.1	0.3	1.5	0.1	-0.0	0.0	-1.2	-0.0	-0.0	0.5	-1.0	-0.1	0.7	-0.0	-0.4	0.3	-0.2	0.3	-0.9	-0.0
Distance traveled before self-admin	0.1	0.1	0.4	-0.2	-0.3	0.3	-0.6	-0.2	-0.3	0.3	-0.1	-0.1	0.0	-0.4	-0.3	0.3	-0.3	0.4	-0.5	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.2	-0.2	0.2	0.6	-0.2	-0.1	-0.1	0.6	-0.0	-0.5	-0.2	0.1	-0.0	0.1	-0.1	0.4	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.6	-0.3	-0.1	0.1	0.5	-0.2	-0.2	-0.1	0.7	-0.2	-0.6	-0.1	0.0	0.1	-0.1	-0.0	0.3	-0.2
Ambulatory time before self-admin	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.5	-0.3	-0.4	0.4	0.1	-0.3	-0.2	-0.4	-0.4	0.4	-0.4	0.4	-0.5	-0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.4	-0.3	-0.3	0.3	0.1	-0.3	-0.1	-0.3	-0.3	0.3	-0.2	0.3	-0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.5	0.0	-0.2	0.2	-0.7	-0.1	-0.2	0.4	-0.6	-0.1	0.4	-0.1	-0.3	0.2	-0.2	0.3	-0.6	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.3	0.4	-0.4	0.5	0.3	0.3	-0.3	-0.2	0.4	0.1	0.4	0.3	-0.3	0.5	-0.4	0.3	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.7	0.0	-0.2	0.2	-0.9	-0.1	-0.2	0.3	-0.6	-0.2	0.4	-0.2	-0.3	0.2	-0.4	0.4	-0.5	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.0	-0.3	-0.3	0.2	0.4	-0.3	-0.4	-0.3	-0.2	0.3	-0.3	0.3	-0.1	-0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.4	0.3	-0.3	0.3	0.3	0.3	-0.4	-0.3	0.4	0.3	0.3	0.4	-0.4	0.3	-0.3	0.5	0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	0.4	-0.4	0.2	0.3	0.3	-0.3	-0.2	0.3	0.4	0.5	0.3	-0.3	0.3	-0.3	0.3	0.3
Cd content in liver	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.5	-0.4	-0.4	0.4	0.2	-0.3	-0.2	-0.4	-0.4	0.4	-0.4	0.4	-0.4	-0.4
Cu content in liver	0.1	0.1	0.8	0.4	0.3	-0.3	-0.5	0.3	0.2	-0.0	-0.9	0.3	0.7	0.3	0.1	-0.1	0.1	-0.0	-0.2	0.2
Rb content in liver	0.1	0.2	0.8	0.2	-0.0	0.0	-0.9	0.0	0.0	0.3	-0.8	-0.1	0.7	-0.0	-0.2	0.1	-0.1	0.2	-0.7	0.1
Mean num. licks in bursts	0.0	0.1	0.2	0.3	0.1	-0.1	-0.1	0.2	0.3	-0.1	-0.5	0.3	0.4	0.1	0.2	-0.2	0.2	-0.2	0.1	0.3
Locomotor testing rearing	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.0	-0.1	-0.1	0.2	-0.1	-0.1	-0.0	0.0	-0.0	0.1	-0.0	0.1	-0.0
Reaction time false alarm rate	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.1	-0.0	-0.2	0.1	0.1	-0.1	0.0	-0.0	0.1	-0.1	-0.0	0.1
Intermittent access total infusions	0.0	0.0	0.2	0.0	0.2	-0.2	0.4	0.1	0.1	-0.2	0.1	0.1	-0.1	0.2	0.2	-0.1	0.2	-0.2	0.3	0.1
Baseline Anxiety	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	-0.2	-0.2	0.1	0.4	-0.2	-0.4	-0.1	-0.1	0.1	-0.0	0.0	0.0	-0.2
Lifetime Intake	0.0	0.0	0.1	0.1	0.3	-0.3	0.1	0.1	0.1	-0.1	-0.1	0.1	0.1	0.2	0.1	-0.1	0.2	-0.2	0.1	0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	-0.0	-0.0	0.0	0.0	0.1	0.0	-0.0	0.1	-0.1	-0.0	0.1
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.1	0.2	-0.2	0.2	0.1	0.1	-0.1	0.0	0.1	0.1	0.1	0.1	-0.1	0.1	-0.2	0.2	0.1
Short access day 10 total infusions	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.1	-0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	-0.0	0.0	0.1	-0.1	-0.0	0.0
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	0.0	-0.0	0.2	0.0	0.0	-0.1	0.1	0.0	-0.1	0.1	0.1	-0.1	0.1	-0.1	0.1	0.0
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	-0.0	0.0	0.3	-0.0	0.2	-0.2	0.2	0.2	0.1	-0.1	0.2	-0.2	0.1	-0.1	0.3	0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.0	0.0	-0.2	0.1	0.3	-0.1	-0.2	-0.2	-0.1	0.1	-0.1	0.1	-0.1	-0.1
Fe content in liver	0.0	0.1	0.2	-0.3	-0.2	0.2	0.2	-0.2	-0.2	0.1	0.5	-0.2	-0.4	-0.2	-0.1	0.1	-0.1	0.1	0.1	-0.2

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.