Hub : Genes

Rps13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	isoform ratio	ENSRNOT00000118821	0.06	0.06	7.1e-03	0.03	0.03	0.04	0.03	1.4e-02	1.3e-02	4.0e-03	1.4e-02
2	Brain	alternative polyA	ENSRNOT00000114376	0.03	0.03	1.7e-03	0.03	0.03	0.03	0.03	6.3e-04	1.9e-03	3.8e-04	5.7e-04
3	Brain	alternative polyA	ENSRNOT00000118821	0.03	0.03	1.7e-03	0.03	0.03	0.03	0.03	6.4e-04	1.9e-03	4.0e-04	6.0e-04
4	Brain	gene expression	ENSRNOG00000068955	0.06	0.04	2.4e-06	0.04	0.05	0.04	0.04	2.7e-04	1.0e-05	1.0e-04	1.1e-04
5	OFC	alternative polyA	ENSRNOT00000114376	0.17	0.16	4.5e-03	0.08	0.06	0.06	0.06	7.5e-03	1.8e-02	1.6e-02	1.4e-02
6	OFC	alternative polyA	ENSRNOT00000118821	0.17	0.16	4.4e-03	0.08	0.06	0.06	0.06	6.0e-03	1.7e-02	1.6e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	5.2	16.9	21.6	-4.7	2.7	-3.0	-4.5	-4.6	4.6
BMI without tail	9.2	19.2	25.1	-5.0	2.7	-3.0	-4.9	-5.0	5.0
Body weight	4.4	18.5	23.7	-4.9	3.0	-3.3	-4.7	-4.8	4.8
Epididymis fat weight	1.6	3.8	4.2	-2.1	1.7	-1.9	-2.0	-2.0	2.0
Glucose	0.0	0.0	0.0	0.2	-0.2	0.2	0.1	0.1	-0.1
Heart weight	0.2	0.3	0.6	-0.5	0.8	-0.8	-0.5	-0.4	0.4
Left kidney weight	6.0	17.2	23.9	-4.9	2.3	-2.7	-4.7	-4.7	4.7
Right kidney weight	6.7	19.0	26.5	-5.2	2.4	-2.7	-5.1	-5.0	5.0
Tail length	2.1	6.4	8.4	-2.9	1.6	-1.8	-2.8	-2.8	2.8
Length with tail	0.9	3.3	4.2	-2.1	1.4	-1.6	-1.9	-1.9	1.9
Length without tail	0.1	0.2	0.4	0.5	-0.0	0.0	0.6	0.6	-0.6
Liver weight, left	2.6	4.2	5.4	-2.3	1.5	-1.6	-2.1	-2.3	2.3
Liver weight, right	3.3	5.6	7.6	-2.8	1.5	-1.7	-2.5	-2.7	2.7
Parametrial fat weight	8.2	16.1	22.0	-4.7	2.3	-2.6	-4.6	-4.5	4.5
Retroperitoneal fat weight	2.3	7.6	9.6	-3.1	1.9	-2.1	-3.1	-3.0	3.0
Intraocular pressure	0.2	0.3	0.5	-0.6	-0.2	0.2	-0.7	-0.7	0.7
Extensor digitorum longus weight	1.8	7.2	11.1	-3.3	0.4	-0.6	-3.3	-3.2	3.2
Soleus weight	0.8	2.3	3.4	-1.8	0.6	-0.7	-1.8	-1.8	1.8
Tibialis anterior weight	3.2	11.2	15.8	-4.0	1.6	-1.8	-3.9	-3.9	3.9
Tibia length	0.0	0.1	0.2	-0.3	0.4	-0.4	-0.2	-0.4	0.4
Number of licking bursts	5.0	5.9	7.8	2.8	-1.7	1.9	2.7	2.6	-2.6
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.1	0.5	-0.5	0.0	-0.0	0.0
Times rat made contact with spout	0.4	0.4	0.7	0.8	-0.2	0.2	0.8	0.7	-0.7
Mean time between licks in bursts	1.2	1.7	2.1	-1.5	1.1	-1.2	-1.2	-1.5	1.5
Mean num. licks in bursts	2.7	3.3	4.0	-2.0	1.5	-1.6	-1.9	-1.9	1.9
Std. dev. time between licks in bursts	2.4	2.9	3.9	-2.0	1.2	-1.3	-1.8	-1.9	1.9
Water consumed over 24 hours	2.9	3.4	4.9	2.2	-0.9	1.1	2.2	2.1	-2.1
Indifference point 0 sec	0.1	0.2	0.4	-0.4	0.6	-0.6	-0.5	-0.2	0.2
Indifference point AUC	1.1	1.3	2.0	-1.3	0.6	-0.7	-1.2	-1.4	1.4
Indifference point function ln k	0.0	0.0	0.1	-0.3	-0.1	0.0	-0.3	-0.1	0.1
Indifference point function log k	0.0	0.0	0.1	-0.3	-0.1	0.0	-0.3	-0.1	0.1
Delay discounting total patch changes 0 sec	0.3	0.5	0.7	-0.7	0.8	-0.8	-0.8	-0.5	0.5
Delay discounting total patch changes 12 sec	0.0	0.1	0.1	0.2	-0.2	0.2	0.0	0.3	-0.3
Delay discounting total patch changes 18 sec	0.0	0.1	0.1	0.2	-0.3	0.3	0.1	0.2	-0.2
Delay discounting total patch changes 24 sec	0.6	0.8	1.1	-0.8	1.0	-1.0	-0.9	-0.8	0.8
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	0.5	0.4	-0.4	0.5	0.5	-0.5
Delay discounting time to switch 0 sec	3.7	5.6	6.9	2.6	-1.8	2.0	2.6	2.5	-2.5
Delay discounting water rate 0 sec	0.7	1.2	1.8	-1.3	0.6	-0.7	-1.3	-1.2	1.2
Delay discounting water rate 12 sec	4.4	6.6	8.8	-3.0	1.6	-1.8	-2.9	-2.9	2.9
Delay discounting water rate 18 sec	1.9	2.5	3.6	-1.9	1.0	-1.1	-1.8	-1.7	1.7
Delay discounting water rate 24 sec	0.2	0.3	0.6	-0.8	0.1	-0.1	-0.8	-0.6	0.6
Delay discounting water rate 6 sec	0.4	0.6	0.9	-0.9	0.4	-0.5	-0.9	-0.8	0.8
Locomotor activity	0.4	0.7	1.0	-0.8	0.9	-1.0	-0.8	-0.7	0.7
Locomotor testing distance	0.1	0.2	0.5	-0.3	0.6	-0.7	-0.5	-0.3	0.3
Locomotor testing rearing	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.4	-0.1	0.1
Light reinforcement 1	0.5	1.0	1.7	1.1	-0.2	0.3	1.0	1.3	-1.3
Light reinforcement 2	0.2	0.2	0.3	0.6	0.4	-0.3	0.6	0.5	-0.5
Reaction time number correct	0.2	0.2	0.4	-0.6	-0.1	0.0	-0.6	-0.5	0.5
Reaction time mean minus median	0.6	0.8	1.0	-1.0	0.7	-0.8	-0.9	-0.9	0.9
Reaction time mean minus median AUC	0.8	1.0	1.5	-1.2	0.7	-0.8	-1.0	-1.1	1.1
Reaction time num false alarms	0.3	0.5	0.9	0.5	-0.9	1.0	0.6	0.5	-0.5
Reaction time num false alarms AUC	0.1	0.1	0.4	0.1	-0.6	0.6	0.3	0.1	-0.1
Reaction time trials correct on left	0.2	0.2	0.4	-0.6	-0.1	0.0	-0.6	-0.5	0.5
Reaction time trials on left	0.2	0.2	0.5	-0.7	-0.0	-0.0	-0.7	-0.5	0.5
Reaction time mean	0.2	0.3	0.3	-0.4	0.5	-0.5	-0.5	-0.5	0.5
Reaction time mean AUC	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.3	-0.4	0.4
Median of all reaction times	0.0	0.0	0.1	-0.1	0.3	-0.3	-0.2	-0.2	0.2
Reaction time omissions	0.0	0.1	0.2	-0.1	0.3	-0.4	-0.2	-0.2	0.2
Reaction time false alarm rate	0.3	0.5	0.7	0.6	-0.8	0.9	0.8	0.5	-0.5
Reaction time premature initiation rate	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.2	-0.1	0.1
Reaction time premature initiations	0.1	0.2	0.4	-0.3	-0.7	0.6	-0.4	-0.3	0.3
Std. dev. reaction times	0.7	1.0	1.2	-1.1	0.8	-0.9	-1.1	-1.0	1.0
Reaction time trials completed	0.2	0.2	0.5	-0.7	-0.0	-0.0	-0.7	-0.5	0.5
Reaction time trials AUC	0.3	0.4	0.6	-0.8	0.0	-0.1	-0.8	-0.7	0.7
Social response proportion	0.9	1.0	1.5	-1.0	1.1	-1.2	-1.0	-0.8	0.8
Social responses	0.3	0.3	0.6	0.7	0.1	-0.1	0.7	0.8	-0.8
Social time	0.3	0.4	0.6	0.7	-0.3	0.3	0.8	0.8	-0.8
Conditioned locomotion	0.2	0.2	0.3	0.5	-0.3	0.3	0.6	0.4	-0.4
Cocaine response after cond. corrected	0.5	0.6	0.7	0.7	-0.8	0.9	0.6	0.7	-0.7
Cocaine response after cond. not corrected	0.3	0.4	0.6	-0.7	-0.2	0.2	-0.8	-0.7	0.7
Cocaine response before conditioning	4.3	5.2	7.3	-2.7	1.1	-1.3	-2.6	-2.7	2.7
Saline control response	0.4	0.6	0.8	-0.8	0.6	-0.7	-0.9	-0.8	0.8
Condit. Reinf. active minus inactive responses	1.5	1.9	2.6	-1.3	1.5	-1.6	-1.2	-1.3	1.3
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.5	-0.9	1.2	-1.2	-0.9	-0.9	0.9
Condit. Reinf. active responses	1.2	1.7	1.9	-1.4	1.2	-1.3	-1.2	-1.3	1.3
Condit. Reinf. inactive responses	0.6	0.8	1.2	-1.1	0.2	-0.3	-1.0	-1.1	1.1
Condit. Reinf. lever presses	3.2	4.4	5.2	-2.3	1.6	-1.8	-2.3	-2.3	2.3
Condit. Reinf. lever reinforcers received	1.0	1.3	1.5	-1.2	1.0	-1.2	-1.1	-1.2	1.2
Pavlov. Cond. lever latency	1.9	2.6	2.8	1.6	-1.5	1.7	1.7	1.6	-1.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.3	0.3	-0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	0.8	1.1	1.8	-0.9	1.3	-1.4	-0.9	-0.9	0.9
Pavlov. Cond. index score	0.6	0.8	0.9	-0.9	0.7	-0.8	-0.9	-0.9	0.9
Pavlov. Cond. latency score	0.4	0.6	0.8	-0.8	0.4	-0.5	-0.9	-0.9	0.9
Pavlov. Cond. lever contacts	3.1	4.3	5.4	-2.2	1.6	-1.7	-2.3	-2.3	2.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.7	0.2	-0.3	-0.7	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	5.9	7.7	10.5	-3.2	1.5	-1.8	-3.1	-3.2	3.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.8	-0.8	0.7	-0.7	-0.9	-0.9	0.9
Pavlov. Cond. response bias	1.4	2.0	2.1	-1.4	1.3	-1.4	-1.4	-1.5	1.5
Conditioned reinforcement - actives	0.3	0.3	0.4	0.6	-0.3	0.3	0.7	0.6	-0.6
Conditioned reinforcement - inactives	0.7	0.7	1.5	1.0	-0.3	0.4	1.2	1.0	-1.0
Conditioned locomotion	1.0	1.2	1.5	1.2	-0.6	0.7	1.2	1.2	-1.2
Intermittent access intake day 1-15 change	0.8	0.8	1.0	0.9	-0.8	0.9	1.0	0.9	-0.9
Intermittent access intake escalation	0.5	0.5	0.6	0.7	-0.7	0.8	0.8	0.7	-0.7
Intermittent access intake escalation 2	0.3	0.3	0.5	0.3	-0.6	0.7	0.5	0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.1	0.2	0.4	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	0.8	-0.3	0.3	0.7	0.8	-0.8
Intermitt. access escalation Index	1.9	1.7	2.4	-1.5	0.5	-0.6	-1.5	-1.5	1.5
Intermittent access day 1 total infusions	0.2	0.3	0.4	-0.5	0.5	-0.6	-0.6	-0.4	0.4
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.2	-0.1	0.1
Intermittent access total infusions	0.1	0.1	0.3	-0.4	0.3	-0.3	-0.5	-0.4	0.4
Intermittent access day 1 locomotion	0.6	0.7	0.9	-0.8	0.7	-0.8	-0.9	-0.8	0.8
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.5	0.7	-0.8	-0.5	-0.5	0.5
Intermittent access total locomotion	0.8	0.9	1.2	-0.9	1.0	-1.1	-0.9	-0.8	0.8
Intermittent access standard deviation	0.3	0.3	0.5	-0.7	0.2	-0.2	-0.6	-0.7	0.7
Cocaine induced anxiety	1.1	1.2	1.6	-1.3	0.8	-0.9	-1.2	-1.2	1.2
Post-drug Anxiety	0.3	0.3	0.5	-0.7	0.3	-0.3	-0.6	-0.7	0.7
Baseline Anxiety	1.6	1.7	1.8	1.3	-1.2	1.3	1.3	1.3	-1.3
Lifetime Intake	0.4	0.5	0.7	-0.7	0.5	-0.6	-0.9	-0.7	0.7
Incentive Sensitization - Responses	0.4	0.4	0.6	0.8	-0.1	0.2	0.7	0.8	-0.8
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	0.8	-0.1	0.1	0.7	0.8	-0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	-0.4	0.4
Progressive ratio test 1 breakpoint	0.4	0.4	0.5	-0.7	0.5	-0.6	-0.7	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.7	0.7	1.3	-0.7	1.1	-1.1	-0.6	-0.7	0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.0	0.3	-0.3	-0.1	0.0	-0.0
Progressive ratio test 2 breakpoint	0.0	0.1	0.1	-0.1	0.4	-0.4	-0.2	-0.0	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.2	0.4	-0.4	0.2	0.2	-0.2
Total sessions with >9 infusions	0.5	0.5	0.8	-0.8	0.5	-0.6	-0.9	-0.8	0.8
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.3	-0.3
Short access day 10 total inactive lever presses	0.5	0.5	0.8	0.9	-0.2	0.3	0.9	0.8	-0.8
Short access day 1 total infusions	0.4	0.4	0.5	-0.6	0.6	-0.7	-0.7	-0.6	0.6
Short access day 10 total infusions	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.4	-0.3	0.3
Short access total infusions	1.0	1.1	1.5	-1.1	0.9	-0.9	-1.2	-1.1	1.1
Short access day 1 locomotion	0.1	0.1	0.1	0.3	0.1	-0.1	0.2	0.3	-0.3
Short access day 10 total locomotion	1.8	1.9	2.2	-1.5	1.2	-1.3	-1.4	-1.4	1.4
Short access total locomotion	1.8	1.8	2.2	-1.4	1.2	-1.3	-1.5	-1.4	1.4
Compulsive drug intake	1.3	1.3	1.7	-1.3	0.6	-0.7	-1.3	-1.3	1.3
One hour access (0.3 mA shock)	1.1	1.2	1.7	-1.3	0.6	-0.7	-1.2	-1.3	1.3
One hour access (shock baseline)	0.1	0.1	0.2	0.4	-0.2	0.3	0.5	0.4	-0.4
Number of responses in last shaping day	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2	-0.1	0.1
Context. condit. distance diff. score	0.6	0.7	1.0	1.0	-0.5	0.5	1.0	1.0	-1.0
Locomotion velocity, session 1	2.2	2.4	3.6	1.9	-0.4	0.6	1.9	1.8	-1.8
Locomotion distance, session 1	0.1	0.2	0.4	0.2	0.6	-0.6	0.3	0.2	-0.2
Locomotion velocity, session 2	2.8	3.2	4.8	2.2	-0.5	0.7	2.2	2.1	-2.1
Locomotion distance, session 2	0.1	0.1	0.1	0.2	0.4	-0.4	0.3	0.2	-0.2
Locomotion velocity, session 3	0.1	0.1	0.2	0.0	0.5	-0.4	0.1	0.0	-0.0
Locomotion distance, session 3	0.2	0.2	0.8	0.0	-0.9	0.8	0.1	0.0	-0.0
Stereotopy head waving bouts, day 3	1.0	1.1	1.8	1.3	0.4	-0.3	1.2	1.3	-1.3
Stereotopy head waving duration, day 3	1.1	1.4	2.2	1.5	0.4	-0.2	1.3	1.4	-1.4
Locomotion velocity, session 7	0.3	0.3	0.6	0.4	-0.7	0.7	0.3	0.4	-0.4
Locomotion distance, session 7	1.1	1.4	2.1	1.1	-1.4	1.5	1.0	1.1	-1.1
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	0.7	0.3	-0.2	0.7	0.8	-0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.4	0.7	-0.8	-0.5	-0.4	0.4
Locomotion velocity, session 8	1.5	1.8	2.5	1.5	-0.9	1.0	1.6	1.5	-1.5
Locomotion distance, session 8	0.7	1.0	1.5	1.2	-0.2	0.3	1.2	1.2	-1.2
Degree of sensitization distance	0.4	0.4	0.6	0.8	-0.5	0.5	0.6	0.8	-0.8
Degree of sensitization stereotypy	0.1	0.1	0.1	0.2	0.3	-0.3	0.2	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.4	0.5	-0.6	-0.4	-0.4	0.4
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.1	-1.1	0.9	-1.0	-1.0	-1.1	1.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.3	-0.3	-0.1	-0.2	0.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.1	-0.2	0.2
Incentive salience index mean	0.2	0.3	0.5	-0.7	0.1	-0.1	-0.6	-0.7	0.7
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.1	-0.6	0.6	0.0	-0.1	0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.5	-0.2	0.2	0.6	0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.2	-0.4	0.4	-0.4	-0.4	-0.4	0.4
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.4	0.5	-0.6	-0.3	-0.4	0.4
Total locomotion distance, hab. session 1	0.6	0.8	1.5	-0.8	1.1	-1.2	-0.7	-0.8	0.8
Locomotion velocity, hab. session 1	0.7	0.9	1.6	-0.9	1.2	-1.3	-0.8	-0.8	0.8
Time in familiar zone, hab. session 2	0.4	0.4	0.5	-0.7	0.4	-0.5	-0.7	-0.7	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.1
Total zone transitions, hab. session 2	0.4	0.5	1.1	-0.6	1.0	-1.1	-0.4	-0.5	0.5
Total locomotion distance, hab. session 2	0.2	0.2	0.6	-0.2	0.7	-0.8	-0.0	-0.2	0.2
Locomotion velocity, hab. session 2	0.2	0.2	0.6	-0.2	0.7	-0.8	-0.1	-0.2	0.2
Novel to familiar place preference ratio	0.2	0.3	0.4	0.5	0.4	-0.4	0.6	0.5	-0.5
Novelty place preference	0.4	0.4	0.8	0.7	0.2	-0.2	0.9	0.7	-0.7
Time in novel zone, NPP test	0.3	0.3	0.5	0.6	0.5	-0.4	0.7	0.6	-0.6
Total zone transitions, NPP test	0.1	0.1	0.2	-0.2	0.5	-0.5	-0.2	-0.2	0.2
Total locomotion distance, NPP test	0.0	0.0	0.1	0.2	0.1	-0.1	0.3	0.3	-0.3
Locomotion velocity, NPP test	0.0	0.0	0.0	0.2	-0.1	0.1	0.2	0.2	-0.2
Pavlov. Cond. lever latency	1.1	1.4	2.3	1.5	0.1	0.0	1.5	1.4	-1.4
Pavlov. Cond. magazine entry latency	4.9	6.3	9.2	-3.0	0.9	-1.2	-3.0	-3.0	3.0
Pavlov. Cond. change in total contacts	1.8	1.9	2.9	-1.7	-0.5	0.4	-1.7	-1.7	1.7
Pavlov. Cond. index score	3.5	4.5	6.9	-2.6	0.4	-0.6	-2.6	-2.5	2.5
Pavlov. Cond. latency score	3.4	4.3	6.6	-2.6	0.5	-0.6	-2.5	-2.5	2.5
Pavlov. Cond. lever contacts	2.2	2.5	4.1	-2.0	0.0	-0.1	-2.0	-1.9	1.9
Pavlov. Cond. magazine entry number	3.0	3.7	5.7	2.4	-0.5	0.6	2.3	2.3	-2.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	0.7	0.0	0.0	0.6	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	4.0	5.0	7.6	-2.8	0.5	-0.7	-2.7	-2.7	2.7
Pavlov. Cond. response bias	2.3	2.9	4.5	-2.1	0.1	-0.3	-2.0	-2.1	2.1
Bone: apparent density	0.4	0.6	0.8	-0.9	0.7	-0.7	-0.8	-0.8	0.8
Bone surface	0.5	1.0	1.3	-1.1	0.6	-0.7	-1.1	-1.1	1.1
Bone volume	0.7	1.2	1.4	-1.2	0.8	-0.9	-1.2	-1.1	1.1
Bone: connectivity density	0.5	0.9	1.3	-1.1	0.5	-0.5	-1.1	-1.0	1.0
Bone: cortical apparent density	1.9	2.5	3.5	1.9	-1.0	1.2	1.7	1.7	-1.7
Bone: cortical area	1.4	2.1	2.8	-1.6	0.9	-1.0	-1.7	-1.6	1.6
Bone: cortical porosity	1.7	1.8	2.5	-1.6	0.7	-0.8	-1.5	-1.6	1.6
Bone: cortical porosity	0.9	1.0	1.2	-1.1	0.7	-0.8	-1.0	-1.1	1.1
Bone: cortical thickness	0.0	0.1	0.1	-0.3	0.0	-0.0	-0.4	-0.3	0.3
Bone: cortical thickness	0.2	0.3	0.6	0.4	-0.8	0.8	0.3	0.4	-0.4
Bone: cortical tissue density	1.9	2.5	3.5	1.9	-1.0	1.2	1.7	1.7	-1.7
Bone: elastic displacement	2.8	3.2	4.6	2.1	-0.8	1.0	2.1	2.1	-2.1
Bone: elastic work	0.3	0.4	0.5	0.7	-0.1	0.2	0.7	0.7	-0.7
Bone: endosteal estimation	1.4	3.0	3.8	-2.0	1.4	-1.5	-1.8	-1.8	1.8
Bone: endosteal perimeter	0.7	1.5	2.1	-1.5	0.8	-0.8	-1.3	-1.4	1.4
Bone: final force	1.6	2.5	2.9	-1.7	1.4	-1.5	-1.6	-1.6	1.6
Bone: final moment	1.3	2.2	2.4	-1.5	1.5	-1.6	-1.5	-1.5	1.5
Bone: marrow area	1.3	2.7	3.6	-1.9	1.3	-1.4	-1.8	-1.8	1.8
Bone: maximum diameter	1.9	3.5	4.6	-2.1	1.2	-1.3	-2.1	-2.1	2.1
Bone: maximum force	1.3	2.2	2.4	-1.6	1.4	-1.5	-1.5	-1.5	1.5
Bone: maximum moment	1.1	1.9	2.3	-1.4	1.4	-1.5	-1.3	-1.3	1.3
Bone: minimum diameter	0.5	1.0	1.3	-1.1	0.8	-0.9	-1.1	-1.0	1.0
Bone: periosteal estimation	1.7	3.5	4.6	-2.2	1.3	-1.4	-2.1	-2.0	2.0
Bone: periosteal perimeter	2.0	3.2	4.1	-2.0	1.3	-1.4	-2.0	-1.9	1.9
Bone: post-yield work	4.4	6.0	6.8	-2.6	2.2	-2.4	-2.5	-2.5	2.5
Bone: stiffness	0.7	1.2	1.4	-1.2	0.9	-1.0	-1.1	-1.2	1.2
Bone: tissue strength	0.2	0.2	0.3	0.3	0.6	-0.5	0.4	0.3	-0.3
Bone: trabecular number	0.0	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	-0.0
Bone: trabecular spacing	0.2	0.3	0.5	-0.7	0.1	-0.1	-0.7	-0.7	0.7
Bone: trabecular thickness	0.9	1.1	1.7	-1.0	1.2	-1.3	-0.9	-0.9	0.9
Bone: trabecular tissue density	0.2	0.3	0.4	0.7	-0.2	0.3	0.6	0.6	-0.6
Breakpoint value in progressive ratio session	3.6	4.0	6.2	2.5	-0.5	0.7	2.5	2.3	-2.3
Distance traveled before self-admin	1.0	1.0	1.3	1.1	-0.9	0.9	1.0	1.1	-1.1
Distance traveled after self-admin	0.1	0.1	0.2	0.0	-0.4	0.5	0.0	0.0	-0.0
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	0.5	-0.3	0.3	0.4	0.4	-0.4
Delta time in open arm before/after self-admin	2.7	2.6	3.4	-1.8	1.2	-1.3	-1.9	-1.7	1.7
Diff in mean of infusions in LGA sessions	0.4	0.4	0.7	0.8	0.4	-0.4	0.8	0.8	-0.8
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.6	0.0	0.0	0.7	0.6	-0.6
Active lever presses in extinction session 6	0.4	0.4	0.9	-0.4	0.9	-1.0	-0.3	-0.4	0.4
Delta distance traveled before/after self-admin	0.7	0.8	1.3	-1.1	0.4	-0.5	-1.0	-1.0	1.0
Delta ambulatory time before/after self-admin	0.4	0.4	0.7	-0.9	0.2	-0.3	-0.7	-0.7	0.7
Time in closed arm before self-admin	0.7	0.7	1.0	-1.0	0.6	-0.7	-1.0	-0.9	0.9
Time in closed arm after self-admin	0.5	0.6	0.8	0.9	-0.5	0.6	0.8	0.8	-0.8
Time in open arm before self-admin	0.5	0.6	0.9	0.9	-0.5	0.6	0.9	0.8	-0.8
Time in open arm after self-admin	1.8	2.0	2.7	-1.6	0.9	-1.0	-1.5	-1.6	1.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.1	0.6	-0.6	-0.0	-0.1	0.1
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.9	-1.0	0.9	-1.0	-0.8	-0.8	0.8
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.8	0.8	-0.5	0.5	0.9	0.9	-0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.0	0.2	-0.2	0.1	0.1	-0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.2	-0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.3	-0.3	0.4	0.2	0.3	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.4	0.2	-0.3	-0.6	-0.5	0.5
Ambulatory time before self-admin	1.9	1.9	2.4	1.6	-1.1	1.2	1.4	1.5	-1.5
Ambulatory time after self-admin	0.4	0.4	0.9	0.4	-0.9	1.0	0.4	0.5	-0.5
Total heroin consumption	1.2	1.5	2.5	1.5	0.0	0.1	1.6	1.4	-1.4
Area under the delay curve	0.3	0.3	0.5	0.7	-0.3	0.3	0.7	0.7	-0.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.3	-0.2	0.3	0.3	0.3	-0.3
Delay disc. indifference point, 16s delay	3.5	3.5	5.1	2.2	-0.7	0.9	2.3	2.2	-2.2
Delay disc. indifference point, 2s delay	0.4	0.4	0.6	-0.8	0.4	-0.4	-0.8	-0.8	0.8
Delay disc. indifference point, 24s delay	1.6	1.6	2.3	1.5	-0.5	0.6	1.5	1.5	-1.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.7	-0.2	0.3	0.7	0.7	-0.7
Delay disc. indifference point, 8s delay	1.0	1.0	1.3	1.1	-0.6	0.7	1.1	1.1	-1.1
Delay discount exponential model param	0.3	0.3	0.4	-0.6	0.2	-0.3	-0.6	-0.6	0.6
Delay discount hyperbolic model param	0.2	0.2	0.3	-0.5	0.1	-0.2	-0.5	-0.5	0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.1	-0.2	0.3	0.2	0.3	-0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.1	0.4	-0.4	0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.9	1.0	-0.2	0.3	0.9	0.8	-0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.3	0.4	0.6	0.7	-0.5	0.5	0.8	0.6	-0.6
Rest time, locomotor task time 1	4.1	4.5	5.1	2.3	-2.0	2.1	2.2	2.0	-2.0
Distance moved, locomotor task time 1	2.4	2.6	3.2	-1.6	1.6	-1.8	-1.6	-1.5	1.5
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.4	0.7	-0.7	-0.4	-0.3	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.2	-0.5	0.5
Bouts of movement, locomotor time 2	0.4	0.4	0.5	-0.7	0.4	-0.5	-0.7	-0.7	0.7
Total resting periods, locomotor time 2	0.5	0.6	0.8	-0.8	0.4	-0.5	-0.9	-0.9	0.9
Rest time, locomotor task time 2	0.9	1.0	1.4	1.2	-0.7	0.8	1.2	1.1	-1.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	-0.2	0.3	0.2	0.1	-0.1
Vertical activity count, locomotor time 2	0.6	0.7	0.9	0.9	-0.4	0.5	1.0	0.9	-0.9
Weight adjusted by age	1.0	1.1	1.3	-1.1	0.9	-1.0	-1.1	-1.1	1.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1	-0.1	0.1
Locomotion in novel chamber	4.2	5.2	7.0	-2.6	1.3	-1.5	-2.6	-2.6	2.6
Locomotion in novel chamber post-restriction	0.5	0.6	1.3	-0.6	1.1	-1.1	-0.6	-0.6	0.6
Progressive ratio	0.1	0.1	0.4	-0.1	0.6	-0.7	0.1	-0.0	0.0
Food seeking constrained by brief footshock	0.4	0.5	0.9	0.8	-0.3	0.3	0.9	0.9	-0.9
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.1	-0.4	0.4	-0.1	-0.0	0.0
Run reversals in cocaine runway, females	1.3	1.3	1.9	-1.4	0.6	-0.6	-1.4	-1.3	1.3
Run reversals in cocaine runway, males	2.0	1.9	2.7	1.5	-0.8	0.9	1.6	1.6	-1.6
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.5	-0.3	0.3	0.3	0.3	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.1	-0.2	0.1	-0.3	-0.3	0.3
Latency to leave start box in cocaine runway, M	1.7	1.6	2.4	1.5	-0.7	0.8	1.4	1.5	-1.5
Cd content in liver	0.7	0.8	1.1	1.1	-0.3	0.3	1.0	1.1	-1.1
Co content in liver	1.1	1.3	2.1	1.4	-0.2	0.3	1.4	1.4	-1.4
Cu content in liver	0.3	0.4	0.8	-0.5	0.8	-0.9	-0.4	-0.4	0.4
Fe content in liver	1.5	1.7	2.1	1.4	-1.1	1.2	1.4	1.4	-1.4
K content in liver	1.3	1.3	1.7	-1.3	0.8	-0.9	-1.0	-1.3	1.3
Mg content in liver	0.8	0.9	1.2	-0.9	1.0	-1.1	-0.7	-0.9	0.9
Mn content in liver	0.6	0.7	1.2	-1.1	0.1	-0.2	-1.0	-1.0	1.0
Na content in liver	1.2	1.3	1.8	-1.3	0.7	-0.8	-1.2	-1.3	1.3
Rb content in liver	0.3	0.3	0.9	-0.3	0.9	-0.9	-0.3	-0.3	0.3
Se content in liver	0.3	0.3	0.5	-0.7	0.2	-0.2	-0.6	-0.7	0.7
Sr content in liver	1.8	1.7	2.3	-1.5	0.6	-0.7	-1.5	-1.5	1.5
Zn content in liver	1.2	1.3	1.5	-1.2	1.1	-1.2	-1.1	-1.1	1.1