Hub : Genes

Diras3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000068695 0.21 0.15 0.0e+00 0.12 0.13 0.13 0.13 1.6e-13 1.4e-14 3.1e-14 2.0e-14
2 Brain gene expression ENSRNOG00000068695 0.04 0.03 1.7e-03 0.03 0.03 0.01 0.02 1.1e-03 1.1e-03 1.5e-02 2.7e-03
3 NAcc gene expression ENSRNOG00000068695 0.08 0.07 1.4e-05 0.06 0.06 0.07 0.07 2.7e-05 2.1e-05 1.1e-05 1.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.27.38.92.7-3.0-2.3
BMI without tail0.20.50.80.7-0.9-0.3
Body weight0.10.61.1-0.60.51.1
Epididymis fat weight4.310.010.83.3-3.2-3.0
Glucose0.71.01.1-1.01.11.0
Heart weight0.00.00.10.2-0.2-0.2
Left kidney weight0.51.51.9-1.01.21.4
Right kidney weight0.30.91.4-0.70.91.2
Tail length3.510.611.8-3.13.23.4
Length with tail3.914.314.9-3.73.93.8
Length without tail1.12.42.8-1.51.71.4
Liver weight, left4.16.77.1-2.52.72.6
Liver weight, right0.00.10.2-0.00.10.4
Parametrial fat weight0.00.00.1-0.20.00.3
Retroperitoneal fat weight0.10.30.40.6-0.6-0.2
Intraocular pressure0.00.10.10.3-0.3-0.2
Extensor digitorum longus weight5.823.323.5-4.84.84.8
Soleus weight0.00.10.10.3-0.1-0.3
Tibialis anterior weight0.31.11.1-1.01.01.0
Tibia length0.71.92.1-1.51.31.4
Number of licking bursts0.20.20.2-0.50.50.5
Food consumed during 24 hour testing period0.10.20.2-0.50.50.3
Times rat made contact with spout0.20.20.3-0.50.40.5
Mean time between licks in bursts1.01.41.81.1-1.2-1.3
Mean num. licks in bursts0.00.00.10.2-0.2-0.2
Std. dev. time between licks in bursts0.70.81.00.8-0.8-1.0
Water consumed over 24 hours2.93.43.7-1.91.81.8
Indifference point 0 sec2.54.04.4-1.92.02.1
Indifference point AUC2.12.52.7-1.61.61.5
Indifference point function ln k0.60.81.0-0.90.81.0
Indifference point function log k0.60.81.0-0.90.81.0
Delay discounting total patch changes 0 sec2.64.24.6-1.92.12.2
Delay discounting total patch changes 12 sec2.33.03.2-1.71.81.8
Delay discounting total patch changes 18 sec0.40.60.6-0.80.80.7
Delay discounting total patch changes 24 sec0.00.00.1-0.10.20.3
Delay discounting total patch changes 6 sec1.42.22.6-1.31.51.6
Delay discounting time to switch 0 sec10.616.116.44.0-4.0-4.0
Delay discounting water rate 0 sec17.527.928.5-5.25.35.3
Delay discounting water rate 12 sec10.315.417.6-3.83.84.2
Delay discounting water rate 18 sec6.07.99.2-2.72.73.0
Delay discounting water rate 24 sec4.66.46.5-2.52.52.6
Delay discounting water rate 6 sec4.36.26.6-2.42.62.5
Locomotor activity0.00.00.1-0.10.3-0.0
Locomotor testing distance0.10.10.3-0.30.60.1
Locomotor testing rearing2.53.84.81.9-1.8-2.2
Light reinforcement 10.00.10.10.3-0.3-0.2
Light reinforcement 20.91.21.31.0-1.2-1.1
Reaction time number correct2.13.03.2-1.61.81.8
Reaction time mean minus median0.00.10.10.2-0.30.2
Reaction time mean minus median AUC0.00.00.10.1-0.30.2
Reaction time num false alarms0.50.81.0-0.71.00.9
Reaction time num false alarms AUC1.11.51.8-1.11.41.2
Reaction time trials correct on left2.13.03.2-1.61.81.8
Reaction time trials on left2.13.03.3-1.61.81.8
Reaction time mean0.70.91.11.0-1.0-0.8
Reaction time mean AUC0.40.50.60.8-0.8-0.6
Median of all reaction times0.60.80.80.9-0.9-0.8
Reaction time omissions1.31.72.4-1.21.11.6
Reaction time false alarm rate0.10.20.2-0.30.50.4
Reaction time premature initiation rate0.50.70.8-0.90.80.8
Reaction time premature initiations1.62.32.4-1.51.51.5
Std. dev. reaction times0.10.10.30.3-0.50.0
Reaction time trials completed2.13.03.3-1.61.81.8
Reaction time trials AUC2.23.23.5-1.71.81.9
Social response proportion0.10.20.2-0.30.30.5
Social responses0.10.10.10.3-0.3-0.4
Social time0.91.21.5-1.01.11.2
Conditioned locomotion0.91.11.2-1.01.01.1
Cocaine response after cond. corrected0.30.30.40.7-0.6-0.5
Cocaine response after cond. not corrected1.61.81.91.4-1.3-1.3
Cocaine response before conditioning2.93.54.11.8-1.8-2.0
Saline control response0.20.30.40.5-0.5-0.6
Condit. Reinf. active minus inactive responses0.20.20.3-0.50.40.5
Condit. Reinf. active-inactive response ratio0.40.40.5-0.60.50.7
Condit. Reinf. active responses0.00.10.10.2-0.3-0.2
Condit. Reinf. inactive responses0.70.90.91.0-0.9-1.0
Condit. Reinf. lever presses1.92.62.71.6-1.6-1.6
Condit. Reinf. lever reinforcers received0.10.10.10.3-0.3-0.2
Pavlov. Cond. lever latency2.33.13.6-1.71.71.9
Pavlov. Cond. magazine entry latency4.85.55.92.4-2.4-2.2
Pavlov. Cond. change in total contacts4.56.26.52.5-2.5-2.4
Pavlov. Cond. index score5.36.97.12.6-2.7-2.6
Pavlov. Cond. latency score5.26.56.72.6-2.6-2.5
Pavlov. Cond. lever contacts2.94.14.51.9-2.0-2.1
Pavlov. Cond. magazine entry number4.45.45.8-2.42.42.2
Pavlov. Cond. intertrial magazine entries4.15.35.7-2.32.42.2
Pavlov. Cond. lever-magazine prob. diff.6.07.88.02.8-2.8-2.7
Pavlov. Cond. response bias4.25.85.92.4-2.4-2.4
Conditioned reinforcement - actives1.91.81.9-1.31.41.4
Conditioned reinforcement - inactives0.30.40.4-0.50.70.6
Conditioned locomotion1.01.21.81.0-0.9-1.3
Intermittent access intake day 1-15 change1.71.72.31.2-1.1-1.5
Intermittent access intake escalation2.01.92.91.3-1.1-1.7
Intermittent access intake escalation 20.20.20.40.3-0.2-0.6
Intermitt. access day 1 inactive lever presses2.42.62.7-1.61.61.6
Intermitt. access day 15 inactive lever presses1.01.11.4-0.81.21.1
Intermitt. access escalation Index0.30.30.5-0.50.40.7
Intermittent access day 1 total infusions0.40.40.60.7-0.8-0.5
Intermittent access day 15 total infusions2.12.32.51.5-1.5-1.6
Intermittent access terminal intake (last 3 days)2.32.52.71.6-1.6-1.5
Intermittent access total infusions0.91.01.11.1-1.0-0.9
Intermittent access day 1 locomotion1.11.21.31.1-1.1-1.0
Intermittent access day 15 total locomotion0.50.50.80.6-0.6-0.9
Intermittent access total locomotion0.70.81.10.8-0.8-1.0
Intermittent access standard deviation3.94.24.71.9-2.0-2.2
Cocaine induced anxiety3.33.74.3-1.91.92.1
Post-drug Anxiety2.73.03.2-1.71.71.8
Baseline Anxiety1.71.82.01.3-1.3-1.4
Lifetime Intake0.50.60.60.8-0.8-0.7
Incentive Sensitization - Responses0.00.00.00.20.0-0.0
Incentive Sensitization - Breakpoint0.00.00.00.10.10.1
Progressive ratio test 1 active lever presses0.10.10.10.3-0.3-0.1
Progressive ratio test 1 breakpoint0.20.20.20.5-0.5-0.4
Progressive ratio test 1 inactive lever presses2.52.73.1-1.61.81.6
Progressive ratio test 2 active lever presses0.00.00.10.3-0.1-0.2
Progressive ratio test 2 breakpoint0.00.00.10.2-0.1-0.2
Progressive ratio test 2 inactive lever presses0.70.80.9-0.80.90.9
Total sessions with >9 infusions0.40.40.60.5-0.6-0.8
Short access day 1 total inactive lever presses0.10.10.20.4-0.2-0.4
Short access day 10 total inactive lever presses0.50.50.6-0.60.80.8
Short access day 1 total infusions0.10.10.1-0.30.30.4
Short access day 10 total infusions0.50.50.70.8-0.8-0.5
Short access total infusions0.30.40.40.6-0.7-0.5
Short access day 1 locomotion1.11.11.21.1-1.1-1.0
Short access day 10 total locomotion1.01.01.40.9-1.0-1.2
Short access total locomotion0.30.30.40.4-0.5-0.6
Compulsive drug intake0.00.00.00.10.00.0
One hour access (0.3 mA shock)0.00.00.1-0.10.30.1
One hour access (shock baseline)0.10.10.20.2-0.2-0.5
Number of responses in last shaping day0.20.20.20.4-0.4-0.5
Context. condit. distance diff. score1.41.72.0-1.41.41.1
Locomotion velocity, session 10.40.50.6-0.70.50.7
Locomotion distance, session 10.30.40.70.5-0.7-0.8
Locomotion velocity, session 20.20.20.20.5-0.4-0.5
Locomotion distance, session 20.30.40.60.6-0.6-0.8
Locomotion velocity, session 30.40.50.70.6-0.6-0.9
Locomotion distance, session 30.00.00.1-0.20.30.0
Stereotopy head waving bouts, day 30.10.10.1-0.40.30.2
Stereotopy head waving duration, day 30.10.10.2-0.40.40.3
Locomotion velocity, session 70.70.81.10.9-0.8-1.0
Locomotion distance, session 71.01.31.51.1-1.1-1.2
Stereotopy head waving bouts, day 70.81.01.1-0.91.01.1
Stereotopy head waving duration, day 70.20.30.4-0.50.50.6
Locomotion velocity, session 80.10.10.1-0.30.30.1
Locomotion distance, session 80.10.10.30.0-0.1-0.5
Degree of sensitization distance0.20.20.30.5-0.5-0.4
Degree of sensitization stereotypy0.20.30.3-0.40.50.6
Condit. Reinf. active minus inactive responses0.40.50.50.6-0.7-0.7
Condit. Reinf. active-inactive response ratio2.22.42.51.5-1.6-1.5
Condit. Reinf. active responses0.20.30.30.5-0.5-0.5
Condit. Reinf. inactive responses1.51.81.9-1.41.41.3
Incentive salience index mean0.40.50.60.6-0.8-0.7
Condit. Reinf. lever presses0.20.20.30.4-0.6-0.5
Time in familiar zone, hab. session 11.41.31.51.2-1.0-1.2
Time in novel zone, hab. session 10.10.10.3-0.30.10.6
Total zone transitions, hab. session 10.50.81.10.7-0.8-1.0
Total locomotion distance, hab. session 10.00.00.1-0.10.3-0.0
Locomotion velocity, hab. session 10.30.50.7-0.70.80.5
Time in familiar zone, hab. session 21.41.51.81.2-1.1-1.3
Time in novel zone, hab. session 20.10.10.2-0.30.20.5
Total zone transitions, hab. session 20.60.71.20.7-0.8-1.1
Total locomotion distance, hab. session 20.50.70.9-0.91.00.5
Locomotion velocity, hab. session 20.70.91.2-1.01.10.7
Novel to familiar place preference ratio0.10.10.20.3-0.4-0.4
Novelty place preference0.10.10.10.3-0.3-0.3
Time in novel zone, NPP test0.00.00.10.2-0.2-0.2
Total zone transitions, NPP test0.10.10.20.2-0.2-0.4
Total locomotion distance, NPP test0.10.20.3-0.50.50.2
Locomotion velocity, NPP test0.20.20.3-0.50.60.3
Pavlov. Cond. lever latency0.70.80.9-0.90.91.0
Pavlov. Cond. magazine entry latency0.70.81.10.9-0.9-1.0
Pavlov. Cond. change in total contacts0.60.60.70.8-0.7-0.8
Pavlov. Cond. index score0.91.11.31.0-1.1-1.1
Pavlov. Cond. latency score0.60.70.90.8-0.8-0.9
Pavlov. Cond. lever contacts0.91.01.11.0-1.0-1.0
Pavlov. Cond. magazine entry number1.21.51.7-1.21.21.3
Pavlov. Cond. intertrial magazine entries5.46.56.6-2.62.52.5
Pavlov. Cond. lever-magazine prob. diff.0.60.70.80.8-0.8-0.9
Pavlov. Cond. response bias1.41.71.91.2-1.2-1.4
Bone: apparent density0.00.10.10.2-0.2-0.4
Bone surface0.00.00.0-0.0-0.1-0.1
Bone volume0.00.00.10.1-0.1-0.3
Bone: connectivity density0.00.00.0-0.10.20.1
Bone: cortical apparent density7.69.910.6-3.13.33.1
Bone: cortical area1.82.73.0-1.71.71.5
Bone: cortical porosity0.00.00.10.10.0-0.3
Bone: cortical porosity0.30.30.50.5-0.4-0.7
Bone: cortical thickness1.42.33.0-1.61.71.1
Bone: cortical thickness1.21.41.8-1.31.40.9
Bone: cortical tissue density7.710.110.6-3.23.33.1
Bone: elastic displacement0.70.81.0-1.01.00.7
Bone: elastic work0.30.40.5-0.70.70.3
Bone: endosteal estimation0.10.20.50.4-0.7-0.1
Bone: endosteal perimeter0.10.20.4-0.40.10.6
Bone: final force0.61.01.2-1.11.00.8
Bone: final moment0.71.21.5-1.21.11.0
Bone: marrow area0.10.20.40.3-0.6-0.1
Bone: maximum diameter0.30.50.6-0.70.60.8
Bone: maximum force0.61.01.2-1.11.00.9
Bone: maximum moment0.61.01.2-1.11.00.9
Bone: minimum diameter0.91.62.0-1.21.11.4
Bone: periosteal estimation0.40.80.9-0.90.70.9
Bone: periosteal perimeter0.40.60.8-0.80.60.9
Bone: post-yield work1.11.51.6-1.21.21.2
Bone: stiffness2.33.73.8-2.01.91.9
Bone: tissue strength0.40.40.4-0.60.60.6
Bone: trabecular number0.00.00.00.00.1-0.1
Bone: trabecular spacing0.00.00.0-0.10.00.0
Bone: trabecular thickness0.10.10.1-0.30.30.2
Bone: trabecular tissue density0.00.10.1-0.20.30.2
Breakpoint value in progressive ratio session0.00.00.1-0.00.1-0.3
Distance traveled before self-admin0.00.00.00.2-0.1-0.0
Distance traveled after self-admin0.50.60.7-0.80.80.6
Delta time in closed arm before/after self-admin0.00.00.00.2-0.1-0.1
Delta time in open arm before/after self-admin0.60.60.8-0.70.70.9
Diff in mean of infusions in LGA sessions0.00.00.1-0.10.2-0.1
Extinction: sum of active levers before priming0.10.10.20.10.1-0.4
Active lever presses in extinction session 61.31.21.5-1.11.21.0
Delta distance traveled before/after self-admin0.00.00.1-0.10.2-0.3
Delta ambulatory time before/after self-admin0.40.40.6-0.80.80.3
Time in closed arm before self-admin2.73.03.31.7-1.8-1.7
Time in closed arm after self-admin1.41.51.81.3-1.3-1.0
Time in open arm before self-admin4.64.95.1-2.22.22.3
Time in open arm after self-admin3.03.33.7-1.81.81.9
Sum of active levers in priming session hrs 5-60.40.40.90.4-0.4-0.9
Time to tail flick, vehicle, before self-admin0.80.80.9-0.90.90.9
Time to tail flick, vehicle, after self-admin0.30.30.40.6-0.5-0.6
Time to tail flick, test, before self-admin0.00.00.0-0.10.10.0
Time to tail flick, test, after self-admin1.91.92.2-1.31.31.5
Delta time to tail flick, vehicle, before/after SA0.30.30.40.5-0.6-0.6
Delta time to tail flick, test, before/after SA1.51.31.4-1.11.21.2
Ambulatory time before self-admin0.00.10.10.3-0.20.1
Ambulatory time after self-admin0.00.00.10.10.0-0.2
Total heroin consumption1.11.31.6-1.31.20.9
Area under the delay curve0.10.10.20.4-0.5-0.1
Delay disc. indifference point, 0s delay0.00.00.1-0.20.10.3
Delay disc. indifference point, 16s delay0.10.10.10.3-0.3-0.0
Delay disc. indifference point, 2s delay0.00.00.10.2-0.2-0.2
Delay disc. indifference point, 24s delay0.00.00.1-0.0-0.00.3
Delay disc. indifference point, 4s delay0.10.10.2-0.20.10.5
Delay disc. indifference point, 8s delay0.30.30.60.6-0.8-0.2
Delay discount exponential model param0.10.10.1-0.30.40.0
Delay discount hyperbolic model param0.10.10.2-0.30.40.1
Fecal boli incidents, locomotor time 11.11.21.50.9-1.2-1.1
Change in fecal boli incidents, locomotor task0.10.10.1-0.10.20.3
Time >=10cm from walls, locomotor time 10.40.40.50.6-0.7-0.6
Bouts of movement, locomotor time 10.91.01.30.8-1.0-1.2
Total resting periods, locomotor time 10.91.01.30.9-1.0-1.1
Rest time, locomotor task time 10.50.60.9-0.70.71.0
Distance moved, locomotor task time 11.01.11.81.0-0.7-1.3
Vertical activity count, locomotor time 10.30.30.5-0.50.70.2
Time >=10cm from walls, locomotor time 20.50.50.6-0.80.70.7
Bouts of movement, locomotor time 22.72.93.2-1.81.81.6
Total resting periods, locomotor time 22.22.32.4-1.51.51.5
Rest time, locomotor task time 20.91.11.4-0.91.11.2
Distance moved, locomotor task time 20.91.01.70.9-0.8-1.3
Vertical activity count, locomotor time 20.20.20.4-0.50.60.1
Weight adjusted by age0.00.00.1-0.20.00.3
Seeking ratio, delayed vs. immediate footshock0.30.30.4-0.60.50.5
Locomotion in novel chamber5.66.97.4-2.52.62.7
Locomotion in novel chamber post-restriction0.00.00.0-0.1-0.00.2
Progressive ratio0.50.50.6-0.80.80.6
Food seeking constrained by brief footshock2.32.82.8-1.71.71.6
Seeking ratio, punishment vs. effort0.10.10.1-0.30.30.4
Run reversals in cocaine runway, females1.01.01.31.1-1.0-0.9
Run reversals in cocaine runway, males1.00.91.1-0.91.01.0
Latency to leave start box in cocaine runway0.30.40.40.6-0.6-0.5
Latency to leave start box in cocaine runway, F0.40.50.50.7-0.7-0.7
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.3-0.2
Cd content in liver0.60.70.8-0.90.90.8
Co content in liver0.60.70.8-0.90.90.8
Cu content in liver0.80.91.11.0-1.0-0.9
Fe content in liver0.00.10.10.3-0.3-0.1
K content in liver0.00.00.0-0.20.20.1
Mg content in liver0.00.00.0-0.0-0.0-0.1
Mn content in liver0.10.10.20.1-0.1-0.4
Na content in liver0.00.00.10.1-0.0-0.3
Rb content in liver0.40.50.8-0.70.60.9
Se content in liver0.10.10.2-0.20.10.4
Sr content in liver0.70.60.7-0.80.70.9
Zn content in liver0.30.30.3-0.60.50.5