| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000068184 | 0.3700 | 0.1300 | 0.0e+00 | 0.246 | 0.245 | 0.241 | 0.246 | 4.2e-27 | 6.5e-27 | 1.9e-26 | 4.5e-27 |
| 2 | BLA | gene expression | ENSRNOG00000068184 | 0.4096 | 0.1434 | 0.0e+00 | 0.264 | 0.243 | 0.328 | 0.250 | 2.1e-14 | 2.9e-13 | 3.6e-18 | 1.3e-13 |
| 3 | BLA | mRNA stability | ENSRNOG00000068184 | 0.1700 | 0.0990 | 2.6e-06 | 0.092 | 0.065 | 0.062 | 0.081 | 1.3e-05 | 2.3e-04 | 3.1e-04 | 3.9e-05 |
| 4 | Brain | gene expression | ENSRNOG00000068184 | 0.0410 | 0.0320 | 3.0e-03 | 0.027 | 0.025 | 0.017 | 0.025 | 1.3e-03 | 2.0e-03 | 8.5e-03 | 1.9e-03 |
| 5 | Brain | mRNA stability | ENSRNOG00000068184 | 0.0575 | 0.0393 | 1.3e-04 | 0.060 | 0.042 | 0.044 | 0.051 | 3.1e-06 | 8.8e-05 | 5.6e-05 | 1.6e-05 |
| 6 | NAcc | gene expression | ENSRNOG00000068184 | 0.0700 | 0.0480 | 1.0e-04 | 0.044 | 0.052 | 0.060 | 0.055 | 3.0e-04 | 9.6e-05 | 3.0e-05 | 6.1e-05 |
| 7 | PL | gene expression | ENSRNOG00000068184 | 0.2532 | 0.1163 | 0.0e+00 | 0.209 | 0.220 | 0.217 | 0.219 | 7.9e-16 | 1.2e-16 | 1.8e-16 | 1.3e-16 |
| 8 | PL | mRNA stability | ENSRNOG00000068184 | 0.1055 | 0.0661 | 3.0e-06 | 0.071 | 0.068 | 0.071 | 0.072 | 4.7e-06 | 6.6e-06 | 4.4e-06 | 4.1e-06 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Locomotion distance, session 3 | 8.0 | 8.7 | 10.5 | -3.2 | 2.9 | -3.1 | 3.2 | -3.0 | 2.3 | 2.5 | -3.2 |
| Cocaine induced anxiety | 6.6 | 7.6 | 9.3 | 3.0 | -2.5 | 3.0 | -3.0 | 3.0 | -2.1 | -2.2 | 3.0 |
| Progressive ratio | 6.2 | 7.2 | 7.7 | 2.5 | -2.8 | 2.7 | -2.6 | 2.7 | -2.6 | -2.7 | 2.7 |
| Body weight | 5.8 | 24.7 | 28.0 | -4.7 | 5.0 | -5.3 | 5.2 | -4.6 | 4.7 | 4.8 | -5.3 |
| Seeking ratio, punishment vs. effort | 5.4 | 6.6 | 8.2 | -2.3 | 2.7 | -2.4 | 2.2 | -2.7 | 2.8 | 2.9 | -2.3 |
| Heart weight | 5.3 | 7.6 | 10.9 | -2.5 | 3.0 | -2.6 | 2.6 | -2.1 | 3.3 | 3.2 | -2.5 |
| Delay disc. indifference point, 0s delay | 5.2 | 5.7 | 6.9 | 2.5 | -2.6 | 2.4 | -2.3 | 1.9 | -2.6 | -2.5 | 2.3 |
| Locomotion distance, session 8 | 5.0 | 7.4 | 11.7 | -2.2 | 3.1 | -2.4 | 2.5 | -2.0 | 3.3 | 3.4 | -2.5 |
| Distance traveled before self-admin | 5.0 | 5.4 | 7.6 | -1.9 | 2.5 | -2.2 | 2.2 | -2.1 | 2.5 | 2.8 | -2.1 |
| Tail length | 4.7 | 14.2 | 18.1 | -3.6 | 3.8 | -4.3 | 4.2 | -3.2 | 3.1 | 3.6 | -4.2 |
| Delay discounting water rate 0 sec | 4.7 | 7.5 | 11.3 | -2.4 | 3.1 | -2.5 | 2.4 | -2.3 | 3.4 | 3.2 | -2.3 |
| Bouts of movement, locomotor time 1 | 4.7 | 5.2 | 6.2 | 2.0 | -2.5 | 2.4 | -2.4 | 1.7 | -2.3 | -2.5 | 2.3 |
| Weight adjusted by age | 4.5 | 5.0 | 7.4 | -2.0 | 2.6 | -2.0 | 2.2 | -1.5 | 2.7 | 2.7 | -2.1 |
| Saline control response | 4.3 | 5.7 | 6.3 | -2.2 | 2.4 | -2.5 | 2.5 | -2.5 | 2.1 | 2.5 | -2.4 |
| Condit. Reinf. active responses | 4.3 | 6.0 | 7.6 | -2.4 | 2.5 | -2.3 | 2.3 | -2.7 | 2.5 | 2.7 | -2.3 |
| BMI without tail | 4.2 | 8.7 | 11.6 | -2.8 | 2.9 | -3.4 | 3.4 | -2.5 | 2.5 | 2.6 | -3.3 |
| Condit. Reinf. active-inactive response ratio | 4.1 | 4.3 | 5.1 | -2.0 | 2.2 | -2.1 | 2.1 | -1.7 | 2.2 | 2.3 | -2.0 |
| Bone: maximum diameter | 4.0 | 7.3 | 8.8 | -2.4 | 2.9 | -2.6 | 2.6 | -2.5 | 2.8 | 3.0 | -2.8 |
| Total resting periods, locomotor time 1 | 4.0 | 4.4 | 5.7 | 1.8 | -2.3 | 2.2 | -2.2 | 1.5 | -2.2 | -2.4 | 2.1 |
| Ambulatory time before self-admin | 3.9 | 4.1 | 5.0 | -1.7 | 2.1 | -2.1 | 2.1 | -1.9 | 1.9 | 2.2 | -2.0 |
| Length with tail | 3.7 | 13.4 | 15.8 | -3.4 | 3.9 | -3.7 | 3.6 | -3.3 | 3.7 | 4.0 | -3.8 |
| Pavlov. Cond. response bias | 3.7 | 5.1 | 5.4 | -2.2 | 2.3 | -2.3 | 2.3 | -2.2 | 2.2 | 2.3 | -2.3 |
| Condit. Reinf. lever reinforcers received | 3.6 | 5.1 | 6.2 | -2.2 | 2.4 | -2.1 | 2.1 | -2.4 | 2.3 | 2.5 | -2.1 |
| Tibia length | 3.5 | 9.9 | 14.4 | -3.3 | 2.8 | -3.5 | 3.6 | -3.3 | 1.9 | 2.4 | -3.8 |
| Condit. Reinf. active minus inactive responses | 3.5 | 4.3 | 5.5 | -1.9 | 2.2 | -1.9 | 1.9 | -2.1 | 2.3 | 2.3 | -1.9 |
| Pavlov. Cond. lever latency | 3.5 | 4.9 | 5.1 | 2.1 | -2.2 | 2.2 | -2.3 | 2.2 | -2.2 | -2.2 | 2.2 |
| Pavlov. Cond. lever contacts | 3.4 | 4.7 | 5.0 | -2.0 | 2.2 | -2.2 | 2.2 | -2.2 | 2.1 | 2.2 | -2.2 |
| Locomotion distance, session 7 | 3.4 | 4.4 | 6.8 | -1.5 | 2.4 | -2.0 | 2.1 | -1.1 | 2.6 | 2.5 | -2.0 |
| Bone: final force | 3.4 | 5.6 | 6.3 | -2.3 | 2.5 | -2.3 | 2.3 | -2.1 | 2.4 | 2.5 | -2.4 |
| Intermittent access intake day 1-15 change | 3.1 | 3.1 | 3.8 | -1.9 | 1.8 | -2.0 | 1.6 | -1.3 | 1.9 | 1.8 | -1.6 |
| Distance traveled after self-admin | 3.1 | 3.4 | 4.0 | -1.7 | 2.0 | -2.0 | 2.0 | -1.4 | 1.8 | 2.0 | -1.9 |
| Rb content in liver | 3.1 | 3.8 | 5.3 | -1.9 | 1.9 | -1.9 | 1.8 | -2.3 | 1.9 | 2.1 | -1.8 |
| Delay discounting time to switch 0 sec | 3.0 | 4.6 | 7.3 | 1.7 | -2.4 | 1.9 | -1.8 | 1.9 | -2.7 | -2.6 | 1.8 |
| Progressive ratio test 1 breakpoint | 3.0 | 3.1 | 3.5 | -1.8 | 1.8 | -1.9 | 1.8 | -1.8 | 1.8 | 1.7 | -1.7 |
| Total zone transitions, hab. session 2 | 3.0 | 3.8 | 4.2 | -1.9 | 2.0 | -1.8 | 1.9 | -2.1 | 1.9 | 1.9 | -2.0 |
| Bone: trabecular number | 3.0 | 4.7 | 5.6 | -2.2 | 2.4 | -2.2 | 2.2 | -1.6 | 2.2 | 2.4 | -2.1 |
| Bone: cortical area | 2.9 | 4.4 | 4.8 | -2.1 | 2.2 | -2.0 | 2.0 | -2.1 | 2.1 | 2.2 | -2.2 |
| Post-drug Anxiety | 2.8 | 3.0 | 3.8 | 1.8 | -1.6 | 1.8 | -1.9 | 1.8 | -1.4 | -1.5 | 2.0 |
| Bone: final moment | 2.7 | 4.5 | 5.1 | -2.1 | 2.3 | -2.1 | 2.1 | -1.8 | 2.1 | 2.2 | -2.2 |
| Pavlov. Cond. index score | 2.6 | 3.4 | 3.7 | -1.8 | 1.9 | -1.9 | 1.9 | -1.9 | 1.7 | 1.8 | -1.9 |
| Progressive ratio test 1 active lever presses | 2.5 | 2.6 | 2.8 | -1.6 | 1.6 | -1.7 | 1.6 | -1.6 | 1.6 | 1.6 | -1.5 |
| Bone: periosteal perimeter | 2.5 | 4.1 | 5.2 | -1.8 | 2.2 | -2.0 | 2.0 | -1.9 | 2.1 | 2.3 | -2.0 |
| Latency to leave start box in cocaine runway, F | 2.5 | 2.8 | 3.8 | 1.4 | -1.8 | 1.8 | -1.8 | 1.0 | -1.8 | -1.9 | 1.5 |
| Conditioned reinforcement - inactives | 2.4 | 2.7 | 5.5 | -1.4 | 1.9 | -1.2 | 1.2 | -1.2 | 2.3 | 2.2 | -1.1 |
| Intermittent access intake escalation | 2.4 | 2.3 | 3.1 | -1.7 | 1.6 | -1.8 | 1.3 | -1.1 | 1.7 | 1.5 | -1.4 |
| Delta ambulatory time before/after self-admin | 2.4 | 2.7 | 4.0 | 1.4 | -1.8 | 1.4 | -1.4 | 1.7 | -1.9 | -2.0 | 1.3 |
| Reaction time num false alarms | 2.3 | 3.2 | 4.5 | -1.5 | 1.9 | -1.5 | 1.5 | -1.9 | 2.1 | 2.1 | -1.6 |
| Bone: periosteal estimation | 2.3 | 4.6 | 6.0 | -1.9 | 2.3 | -2.2 | 2.2 | -1.7 | 2.0 | 2.3 | -2.4 |
| Delay discounting water rate 6 sec | 2.2 | 3.1 | 3.6 | -1.7 | 1.9 | -1.7 | 1.7 | -1.6 | 1.9 | 1.9 | -1.7 |
| Social responses | 2.2 | 2.8 | 4.9 | -1.6 | 1.7 | -1.4 | 1.6 | -2.2 | 1.5 | 1.7 | -1.6 |
| Pavlov. Cond. change in total contacts | 2.2 | 3.1 | 3.8 | -1.7 | 1.7 | -1.8 | 1.8 | -2.0 | 1.5 | 1.6 | -1.8 |
| Reaction time num false alarms AUC | 2.1 | 2.9 | 3.7 | -1.6 | 1.8 | -1.5 | 1.5 | -1.9 | 1.8 | 1.9 | -1.7 |
| Locomotion distance, session 2 | 2.1 | 3.0 | 4.5 | -1.6 | 1.9 | -1.3 | 1.4 | -1.8 | 2.1 | 2.1 | -1.5 |
| Bone: apparent density | 2.1 | 3.5 | 4.6 | -1.9 | 2.1 | -1.8 | 1.8 | -1.4 | 2.1 | 2.1 | -1.7 |
| Bone: endosteal perimeter | 2.1 | 4.4 | 5.7 | -1.9 | 2.3 | -2.1 | 2.1 | -1.6 | 2.1 | 2.4 | -2.1 |
| Run reversals in cocaine runway, males | 2.1 | 2.0 | 3.7 | -1.3 | 1.4 | -1.2 | 1.1 | -1.9 | 1.5 | 1.4 | -1.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.0 | 2.6 | 2.9 | -1.6 | 1.6 | -1.6 | 1.7 | -1.7 | 1.4 | 1.5 | -1.7 |
| Se content in liver | 2.0 | 2.4 | 3.3 | -1.3 | 1.6 | -1.4 | 1.4 | -1.3 | 1.8 | 1.8 | -1.5 |
| Stereotopy head waving bouts, day 3 | 1.9 | 2.3 | 3.5 | 1.7 | -1.3 | 1.8 | -1.8 | 1.5 | -0.9 | -0.9 | 1.9 |
| Locomotion velocity, session 7 | 1.9 | 2.1 | 3.0 | -1.0 | 1.6 | -1.6 | 1.7 | -0.8 | 1.3 | 1.6 | -1.7 |
| Conditioned locomotion | 1.8 | 2.1 | 3.5 | -1.2 | 1.6 | -1.1 | 1.1 | -1.7 | 1.7 | 1.9 | -1.1 |
| Pavlov. Cond. latency score | 1.8 | 2.3 | 2.5 | -1.4 | 1.6 | -1.5 | 1.6 | -1.5 | 1.4 | 1.5 | -1.6 |
| Stereotopy head waving duration, day 3 | 1.8 | 2.2 | 3.0 | 1.5 | -1.5 | 1.7 | -1.6 | 1.3 | -1.3 | -1.2 | 1.7 |
| Cu content in liver | 1.7 | 2.1 | 3.1 | -1.8 | 1.3 | -1.5 | 1.4 | -1.7 | 1.1 | 1.2 | -1.4 |
| Condit. Reinf. lever presses | 1.6 | 2.2 | 2.5 | -1.5 | 1.5 | -1.5 | 1.5 | -1.6 | 1.4 | 1.4 | -1.5 |
| Time in closed arm after self-admin | 1.6 | 1.7 | 3.0 | 1.2 | -1.4 | 1.1 | -1.0 | 1.4 | -1.7 | -1.5 | 0.8 |
| Delta time to tail flick, vehicle, before/after SA | 1.6 | 1.6 | 2.2 | -1.4 | 1.2 | -1.3 | 1.5 | -1.3 | 1.0 | 1.1 | -1.3 |
| Total heroin consumption | 1.6 | 1.9 | 4.2 | -1.2 | 1.3 | -1.1 | 1.2 | -2.1 | 1.4 | 1.5 | -1.1 |
| Mn content in liver | 1.6 | 1.9 | 2.9 | -1.5 | 1.4 | -1.2 | 1.3 | -1.7 | 1.1 | 1.2 | -1.4 |
| Progressive ratio test 2 inactive lever presses | 1.5 | 1.7 | 3.4 | -1.1 | 1.5 | -1.0 | 1.1 | -0.9 | 1.8 | 1.7 | -0.9 |
| Delta time in open arm before/after self-admin | 1.5 | 1.4 | 2.0 | -1.0 | 1.2 | -1.1 | 1.1 | -1.3 | 1.3 | 1.4 | -1.0 |
| Delay disc. indifference point, 24s delay | 1.5 | 1.5 | 1.9 | 1.4 | -1.3 | 1.2 | -1.1 | 1.0 | -1.3 | -1.1 | 1.1 |
| Latency to leave start box in cocaine runway | 1.5 | 1.6 | 2.2 | 1.2 | -1.3 | 1.5 | -1.4 | 0.8 | -1.4 | -1.3 | 1.2 |
| Tibialis anterior weight | 1.4 | 5.0 | 6.0 | -2.2 | 2.2 | -2.4 | 2.4 | -1.9 | 2.1 | 2.1 | -2.4 |
| Intermitt. access day 1 inactive lever presses | 1.4 | 1.5 | 2.4 | -1.1 | 1.4 | -0.9 | 1.1 | -0.9 | 1.6 | 1.5 | -1.1 |
| Total locomotion distance, hab. session 2 | 1.4 | 1.8 | 4.4 | -1.0 | 1.5 | -0.7 | 0.8 | -1.2 | 2.1 | 1.9 | -0.8 |
| Bone volume | 1.4 | 2.4 | 3.5 | -1.4 | 1.7 | -1.4 | 1.4 | -1.2 | 1.8 | 1.9 | -1.4 |
| Time to tail flick, test, after self-admin | 1.4 | 1.5 | 2.2 | 1.5 | -1.1 | 1.3 | -1.4 | 1.3 | -0.9 | -0.8 | 1.2 |
| Ambulatory time after self-admin | 1.4 | 1.6 | 2.2 | -1.2 | 1.2 | -1.5 | 1.5 | -1.0 | 1.0 | 1.2 | -1.4 |
| BMI with tail | 1.3 | 4.1 | 5.0 | -1.9 | 2.0 | -2.2 | 2.2 | -2.0 | 1.7 | 1.7 | -2.2 |
| Reaction time false alarm rate | 1.3 | 1.9 | 2.6 | -1.3 | 1.4 | -1.1 | 1.2 | -1.6 | 1.5 | 1.4 | -1.3 |
| Baseline Anxiety | 1.3 | 1.4 | 1.8 | -1.3 | 1.1 | -1.4 | 1.2 | -1.3 | 0.9 | 0.9 | -1.2 |
| Total locomotion distance, NPP test | 1.3 | 1.8 | 4.4 | -0.9 | 1.6 | -0.8 | 0.9 | -0.8 | 2.1 | 1.9 | -0.9 |
| Short access day 10 total locomotion | 1.2 | 1.3 | 1.6 | -1.2 | 1.2 | -1.1 | 1.2 | -1.0 | 1.1 | 1.0 | -1.2 |
| Time in novel zone, hab. session 2 | 1.2 | 1.2 | 1.6 | -1.1 | 1.1 | -1.1 | 1.1 | -1.0 | 1.0 | 1.0 | -1.3 |
| Bone surface | 1.2 | 2.2 | 3.2 | -1.4 | 1.7 | -1.4 | 1.3 | -1.1 | 1.7 | 1.8 | -1.3 |
| Locomotion in novel chamber post-restriction | 1.2 | 1.4 | 2.3 | -1.2 | 1.1 | -1.3 | 1.3 | -1.3 | 0.7 | 1.0 | -1.5 |
| Mg content in liver | 1.2 | 1.3 | 2.3 | -1.2 | 1.1 | -0.9 | 1.0 | -1.5 | 1.0 | 1.1 | -1.2 |
| Reaction time mean minus median | 1.1 | 1.4 | 2.2 | 1.1 | -1.1 | 1.2 | -1.3 | 1.5 | -0.8 | -1.1 | 1.4 |
| Progressive ratio test 1 inactive lever presses | 1.1 | 1.2 | 2.1 | -0.9 | 1.2 | -0.8 | 0.9 | -1.0 | 1.5 | 1.4 | -0.8 |
| Context. condit. distance diff. score | 1.1 | 1.4 | 2.7 | -0.5 | 1.3 | -1.1 | 1.1 | -0.2 | 1.6 | 1.6 | -1.1 |
| Time in familiar zone, hab. session 2 | 1.1 | 1.2 | 1.5 | 1.1 | -1.1 | 1.2 | -1.1 | 1.0 | -1.0 | -1.0 | 1.2 |
| Bone: connectivity density | 1.1 | 1.8 | 2.2 | -1.5 | 1.5 | -1.3 | 1.3 | -1.0 | 1.5 | 1.5 | -1.2 |
| Bone: minimum diameter | 1.1 | 2.1 | 2.6 | -1.4 | 1.6 | -1.4 | 1.4 | -1.4 | 1.4 | 1.5 | -1.6 |
| Bone: trabecular tissue density | 1.1 | 1.5 | 2.6 | -1.0 | 1.3 | -1.0 | 1.0 | -1.4 | 1.6 | 1.4 | -0.8 |
| Diff in mean of infusions in LGA sessions | 1.1 | 1.2 | 1.7 | 1.1 | -1.2 | 1.0 | -0.8 | 1.1 | -1.3 | -1.2 | 1.0 |
| Delta time to tail flick, test, before/after SA | 1.1 | 1.0 | 1.9 | 1.4 | -0.8 | 1.1 | -1.1 | 1.3 | -0.5 | -0.5 | 1.0 |
| Run reversals in cocaine runway, females | 1.1 | 1.1 | 1.5 | -0.8 | 1.2 | -0.9 | 1.2 | -0.4 | 1.2 | 1.2 | -1.1 |
| Co content in liver | 1.1 | 1.3 | 1.8 | -1.0 | 1.1 | -1.1 | 1.1 | -1.4 | 0.9 | 1.2 | -1.1 |
| Sr content in liver | 1.1 | 1.0 | 1.6 | -0.6 | 1.0 | -1.2 | 1.3 | -0.5 | 0.7 | 1.0 | -1.2 |
| Delay discounting total patch changes 24 sec | 1.0 | 1.2 | 3.1 | 1.4 | -0.6 | 1.2 | -1.3 | 1.8 | -0.0 | -0.3 | 1.1 |
| Intermittent access day 15 total infusions | 1.0 | 1.1 | 1.7 | -1.2 | 1.1 | -1.1 | 0.9 | -0.6 | 1.3 | 1.0 | -0.8 |
| Compulsive drug intake | 1.0 | 1.0 | 1.7 | 1.0 | -1.0 | 0.9 | -0.9 | 0.8 | -1.3 | -1.1 | 0.6 |
| Degree of sensitization distance | 1.0 | 1.0 | 2.5 | 1.4 | -0.5 | 1.0 | -0.9 | 1.6 | 0.0 | -0.1 | 1.1 |
| Bone: post-yield work | 1.0 | 1.3 | 1.9 | 1.3 | -1.1 | 1.2 | -1.1 | 1.4 | -1.2 | -0.9 | 1.0 |
| Bone: stiffness | 1.0 | 1.6 | 2.4 | -1.0 | 1.4 | -1.0 | 1.0 | -1.3 | 1.5 | 1.6 | -1.2 |
| Breakpoint value in progressive ratio session | 1.0 | 1.1 | 1.9 | -1.0 | 0.9 | -1.1 | 1.2 | -1.4 | 0.7 | 0.9 | -1.0 |
| Std. dev. time between licks in bursts | 0.9 | 1.0 | 1.4 | -0.8 | 1.0 | -1.2 | 1.2 | -0.7 | 0.9 | 1.1 | -1.1 |
| Delay discounting water rate 12 sec | 0.9 | 1.4 | 2.5 | -1.0 | 1.4 | -1.0 | 1.0 | -0.7 | 1.6 | 1.5 | -1.1 |
| Delay discounting water rate 24 sec | 0.9 | 1.2 | 1.4 | -1.2 | 1.2 | -1.0 | 1.1 | -1.1 | 1.1 | 1.0 | -1.2 |
| Conditioned reinforcement - actives | 0.9 | 0.8 | 1.1 | -1.0 | 0.9 | -1.1 | 1.0 | -0.8 | 0.9 | 0.9 | -0.7 |
| Intermittent access day 15 total locomotion | 0.9 | 1.0 | 2.3 | -0.9 | 1.1 | -0.7 | 0.7 | -0.8 | 1.5 | 1.3 | -0.4 |
| Intermittent access total locomotion | 0.9 | 1.0 | 1.9 | -1.0 | 1.1 | -0.9 | 0.9 | -0.4 | 1.4 | 1.1 | -0.7 |
| One hour access (0.3 mA shock) | 0.9 | 1.0 | 1.7 | -1.0 | 1.1 | -1.0 | 0.8 | -0.8 | 1.3 | 1.1 | -0.8 |
| Locomotion velocity, session 3 | 0.9 | 1.1 | 2.0 | -1.1 | 0.9 | -1.1 | 1.2 | -1.2 | 0.4 | 0.6 | -1.4 |
| Degree of sensitization stereotypy | 0.9 | 1.0 | 1.8 | -1.1 | 0.7 | -1.1 | 1.1 | -1.3 | 0.4 | 0.4 | -1.3 |
| Condit. Reinf. active-inactive response ratio | 0.9 | 1.0 | 1.6 | -1.1 | 1.0 | -0.8 | 0.7 | -1.1 | 1.3 | 1.0 | -0.6 |
| Length without tail | 0.8 | 1.8 | 2.6 | -1.2 | 1.5 | -1.0 | 1.0 | -1.5 | 1.6 | 1.6 | -1.2 |
| Locomotion velocity, hab. session 2 | 0.8 | 1.0 | 3.1 | -0.6 | 1.2 | -0.3 | 0.3 | -0.8 | 1.8 | 1.6 | -0.4 |
| Locomotion velocity, NPP test | 0.8 | 1.1 | 3.0 | -0.6 | 1.3 | -0.6 | 0.6 | -0.4 | 1.7 | 1.6 | -0.6 |
| Bone: cortical thickness | 0.8 | 1.3 | 2.7 | -1.3 | 1.1 | -0.9 | 0.9 | -1.6 | 1.1 | 1.0 | -1.0 |
| Bone: endosteal estimation | 0.8 | 1.7 | 2.7 | -0.9 | 1.5 | -1.4 | 1.4 | -0.4 | 1.2 | 1.6 | -1.6 |
| Bone: marrow area | 0.8 | 1.6 | 2.5 | -0.9 | 1.5 | -1.4 | 1.4 | -0.4 | 1.2 | 1.6 | -1.6 |
| Epididymis fat weight | 0.7 | 1.6 | 2.0 | -1.1 | 1.2 | -1.4 | 1.4 | -1.2 | 1.2 | 1.2 | -1.3 |
| Left kidney weight | 0.7 | 2.1 | 4.2 | -1.0 | 1.7 | -1.2 | 1.2 | -1.0 | 1.9 | 2.1 | -1.2 |
| Delay discounting total patch changes 18 sec | 0.7 | 1.0 | 2.1 | 1.2 | -0.7 | 1.1 | -1.2 | 1.4 | -0.3 | -0.5 | 1.0 |
| Light reinforcement 1 | 0.7 | 1.3 | 1.8 | -1.0 | 1.1 | -1.2 | 1.2 | -1.1 | 1.0 | 1.2 | -1.3 |
| Pavlov. Cond. magazine entry number | 0.7 | 0.9 | 1.1 | 1.0 | -1.0 | 1.0 | -1.0 | 0.8 | -0.8 | -0.9 | 1.0 |
| Short access day 10 total inactive lever presses | 0.7 | 0.8 | 1.5 | 1.0 | -0.4 | 1.2 | -1.1 | 1.2 | 0.0 | -0.1 | 1.1 |
| Time in familiar zone, hab. session 1 | 0.7 | 0.7 | 1.2 | 0.9 | -0.9 | 0.7 | -0.6 | 0.9 | -1.1 | -0.9 | 0.5 |
| Locomotion velocity, hab. session 1 | 0.7 | 1.0 | 2.3 | -0.6 | 1.2 | -0.5 | 0.5 | -0.6 | 1.4 | 1.5 | -0.8 |
| Total zone transitions, NPP test | 0.7 | 0.9 | 1.2 | -0.9 | 1.0 | -0.9 | 1.0 | -0.8 | 1.1 | 1.0 | -1.0 |
| Bone: trabecular thickness | 0.7 | 0.8 | 1.1 | -0.9 | 1.0 | -0.9 | 0.8 | -1.0 | 1.0 | 1.0 | -0.8 |
| Time in closed arm before self-admin | 0.7 | 0.7 | 1.1 | 1.0 | -0.9 | 0.7 | -0.7 | 1.0 | -1.0 | -0.8 | 0.6 |
| Right kidney weight | 0.6 | 1.7 | 3.6 | -0.9 | 1.6 | -1.0 | 1.1 | -0.8 | 1.7 | 1.9 | -1.1 |
| Delay discounting water rate 18 sec | 0.6 | 0.8 | 1.1 | -0.9 | 0.9 | -0.9 | 1.0 | -1.0 | 0.7 | 0.9 | -0.8 |
| Locomotor activity | 0.6 | 0.9 | 1.3 | -1.1 | 1.0 | -1.0 | 0.9 | -0.9 | 0.8 | 1.0 | -1.2 |
| Intermittent access intake escalation 2 | 0.6 | 0.6 | 0.9 | -1.0 | 0.8 | -0.9 | 0.6 | -0.5 | 0.9 | 0.8 | -0.6 |
| Intermitt. access escalation Index | 0.6 | 0.5 | 1.1 | 0.5 | -0.8 | 0.5 | -0.7 | 0.4 | -1.0 | -1.0 | 0.3 |
| Intermittent access terminal intake (last 3 days) | 0.6 | 0.7 | 1.5 | -0.9 | 0.9 | -0.8 | 0.5 | -0.4 | 1.2 | 0.9 | -0.4 |
| Locomotion distance, session 1 | 0.6 | 0.8 | 1.7 | -0.6 | 1.1 | -0.6 | 0.6 | -0.8 | 1.2 | 1.3 | -0.7 |
| Locomotion velocity, session 8 | 0.6 | 0.7 | 1.2 | -0.7 | 1.0 | -0.7 | 0.7 | -0.7 | 1.0 | 1.1 | -0.8 |
| Total zone transitions, hab. session 1 | 0.6 | 0.8 | 1.5 | -0.6 | 1.0 | -0.6 | 0.7 | -0.9 | 1.2 | 1.2 | -0.8 |
| Total locomotion distance, hab. session 1 | 0.6 | 0.8 | 2.2 | -0.3 | 1.1 | -0.4 | 0.5 | -0.5 | 1.4 | 1.5 | -0.7 |
| Bone: cortical porosity | 0.6 | 0.6 | 2.0 | 0.3 | -0.9 | 0.4 | -0.4 | 0.1 | -1.4 | -1.3 | 0.2 |
| Bone: trabecular spacing | 0.6 | 0.7 | 1.1 | 0.8 | -0.9 | 1.0 | -1.0 | 0.5 | -0.5 | -0.9 | 1.0 |
| Time in open arm after self-admin | 0.6 | 0.7 | 1.4 | -0.5 | 1.0 | -0.7 | 0.7 | -0.7 | 1.2 | 1.2 | -0.5 |
| Time to tail flick, test, before self-admin | 0.6 | 0.5 | 0.9 | -0.9 | 0.6 | -0.8 | 0.8 | -0.8 | 0.5 | 0.5 | -0.8 |
| Food consumed during 24 hour testing period | 0.5 | 0.6 | 1.3 | 0.8 | -0.6 | 0.8 | -0.8 | 1.1 | -0.5 | -0.5 | 0.9 |
| Locomotor testing rearing | 0.5 | 0.8 | 1.7 | -0.8 | 1.1 | -0.6 | 0.6 | -0.8 | 1.1 | 1.3 | -0.8 |
| Reaction time omissions | 0.5 | 0.7 | 1.2 | -0.8 | 0.8 | -0.6 | 0.5 | -1.1 | 1.0 | 0.9 | -0.4 |
| Condit. Reinf. inactive responses | 0.5 | 0.6 | 1.3 | -0.7 | 0.8 | -0.6 | 0.6 | -1.1 | 0.8 | 0.9 | -0.7 |
| Intermitt. access day 15 inactive lever presses | 0.5 | 0.5 | 1.7 | -0.2 | 0.9 | -0.2 | 0.4 | -0.0 | 1.3 | 1.2 | -0.3 |
| Short access total locomotion | 0.5 | 0.5 | 0.8 | -0.7 | 0.8 | -0.7 | 0.7 | -0.4 | 0.9 | 0.8 | -0.5 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 1.2 | -1.1 | 0.7 | -0.7 | 0.6 | -1.1 | 0.9 | 0.5 | -0.5 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.7 | 0.8 | 0.9 | -0.8 | 0.8 | -0.8 | 0.8 | -0.9 | -0.6 | 0.8 |
| Pavlov. Cond. response bias | 0.5 | 0.6 | 1.0 | -0.8 | 0.9 | -0.7 | 0.7 | -0.6 | 1.0 | 0.8 | -0.6 |
| Bone: maximum force | 0.5 | 0.9 | 1.3 | -0.8 | 1.1 | -0.8 | 0.8 | -0.7 | 1.1 | 1.1 | -1.0 |
| Time to tail flick, vehicle, before self-admin | 0.5 | 0.5 | 1.7 | 0.8 | -0.4 | 0.7 | -0.8 | 1.3 | -0.0 | -0.2 | 0.6 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 0.8 | -0.8 | 0.6 | -0.7 | 0.9 | -0.7 | 0.3 | 0.4 | -0.8 |
| Rest time, locomotor task time 1 | 0.5 | 0.6 | 0.8 | 0.7 | -0.9 | 0.7 | -0.7 | 0.6 | -0.9 | -0.9 | 0.6 |
| Mean num. licks in bursts | 0.4 | 0.5 | 1.1 | 0.3 | -0.5 | 1.1 | -1.1 | -0.3 | -0.5 | -0.3 | 1.0 |
| Delay discounting total patch changes 6 sec | 0.4 | 0.6 | 1.6 | -0.7 | 1.0 | -0.4 | 0.4 | -0.4 | 1.3 | 1.1 | -0.5 |
| Light reinforcement 2 | 0.4 | 0.5 | 0.6 | -0.7 | 0.7 | -0.7 | 0.8 | -0.5 | 0.8 | 0.7 | -0.7 |
| Reaction time mean minus median AUC | 0.4 | 0.6 | 1.0 | 0.7 | -0.7 | 0.8 | -0.8 | 0.9 | -0.4 | -0.6 | 1.0 |
| Conditioned locomotion | 0.4 | 0.5 | 0.7 | -0.7 | 0.8 | -0.8 | 0.9 | -0.4 | 0.7 | 0.7 | -0.7 |
| Intermittent access standard deviation | 0.4 | 0.5 | 0.9 | -0.9 | 0.7 | -0.8 | 0.5 | -0.3 | 0.9 | 0.6 | -0.5 |
| Time in novel zone, hab. session 1 | 0.4 | 0.4 | 1.4 | -0.3 | 0.6 | -0.4 | 0.3 | -0.5 | 1.2 | 0.8 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.4 | 0.5 | 1.5 | -0.6 | 0.9 | -0.4 | 0.4 | -0.5 | 1.2 | 0.8 | -0.4 |
| Area under the delay curve | 0.4 | 0.4 | 0.7 | 0.8 | -0.7 | 0.6 | -0.4 | 0.3 | -0.8 | -0.6 | 0.5 |
| Delay disc. indifference point, 16s delay | 0.4 | 0.4 | 0.5 | 0.7 | -0.7 | 0.7 | -0.6 | 0.6 | -0.6 | -0.7 | 0.7 |
| Delay discount exponential model param | 0.4 | 0.4 | 0.7 | -0.8 | 0.7 | -0.6 | 0.4 | -0.3 | 0.8 | 0.6 | -0.5 |
| Bouts of movement, locomotor time 2 | 0.4 | 0.5 | 1.2 | 0.3 | -0.8 | 0.5 | -0.4 | 0.7 | -0.9 | -1.1 | 0.4 |
| Total resting periods, locomotor time 2 | 0.4 | 0.4 | 1.1 | 0.2 | -0.7 | 0.4 | -0.3 | 0.5 | -0.9 | -1.1 | 0.3 |
| Locomotion in novel chamber | 0.4 | 0.5 | 0.9 | -0.6 | 0.8 | -0.7 | 0.9 | -0.3 | 0.5 | 0.7 | -0.9 |
| Glucose | 0.3 | 0.4 | 0.5 | -0.7 | 0.7 | -0.6 | 0.6 | -0.3 | 0.7 | 0.7 | -0.7 |
| Number of licking bursts | 0.3 | 0.3 | 0.7 | -0.1 | 0.4 | -0.9 | 0.9 | 0.6 | 0.4 | 0.2 | -0.7 |
| Indifference point AUC | 0.3 | 0.4 | 0.7 | -0.7 | 0.7 | -0.6 | 0.5 | -0.4 | 0.8 | 0.6 | -0.6 |
| Indifference point function ln k | 0.3 | 0.4 | 0.8 | -0.4 | 0.7 | -0.5 | 0.5 | -0.6 | 0.8 | 0.9 | -0.6 |
| Indifference point function log k | 0.3 | 0.4 | 0.8 | -0.4 | 0.7 | -0.5 | 0.5 | -0.6 | 0.8 | 0.9 | -0.6 |
| Median of all reaction times | 0.3 | 0.4 | 0.6 | -0.6 | 0.6 | -0.8 | 0.7 | -0.4 | 0.7 | 0.6 | -0.7 |
| Reaction time premature initiation rate | 0.3 | 0.4 | 0.7 | -0.4 | 0.5 | -0.8 | 0.8 | -0.3 | 0.4 | 0.4 | -0.8 |
| Social response proportion | 0.3 | 0.4 | 0.7 | -0.4 | 0.7 | -0.3 | 0.4 | -0.7 | 0.8 | 0.9 | -0.4 |
| Cocaine response after cond. not corrected | 0.3 | 0.3 | 0.6 | 0.6 | -0.5 | 0.8 | -0.8 | 0.3 | -0.3 | -0.4 | 0.6 |
| Intermittent access day 1 total infusions | 0.3 | 0.3 | 0.4 | 0.5 | -0.6 | 0.6 | -0.4 | 0.6 | -0.5 | -0.6 | 0.6 |
| Progressive ratio test 2 active lever presses | 0.3 | 0.4 | 0.8 | -0.5 | 0.7 | -0.5 | 0.4 | -0.4 | 0.9 | 0.8 | -0.3 |
| Short access day 1 total inactive lever presses | 0.3 | 0.3 | 0.5 | -0.7 | 0.6 | -0.4 | 0.5 | -0.3 | 0.7 | 0.5 | -0.4 |
| One hour access (shock baseline) | 0.3 | 0.3 | 0.8 | -0.7 | 0.6 | -0.5 | 0.4 | -0.4 | 0.9 | 0.6 | -0.3 |
| Stereotopy head waving duration, day 7 | 0.3 | 0.3 | 0.9 | 0.3 | -0.7 | 0.4 | -0.4 | -0.1 | -0.9 | -0.8 | 0.3 |
| Incentive salience index mean | 0.3 | 0.4 | 0.8 | -0.7 | 0.6 | -0.5 | 0.4 | -0.7 | 0.9 | 0.6 | -0.3 |
| Novelty place preference | 0.3 | 0.3 | 0.7 | 0.6 | -0.4 | 0.5 | -0.6 | 0.8 | -0.2 | -0.3 | 0.5 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.4 | 0.7 | -0.9 | 0.6 | -0.7 | 0.7 | -0.6 | 0.4 | 0.6 | -0.7 |
| Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 0.4 | 0.6 | -0.5 | 0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.4 |
| Active lever presses in extinction session 6 | 0.3 | 0.3 | 0.6 | 0.8 | -0.5 | 0.7 | -0.5 | 0.2 | -0.5 | -0.3 | 0.7 |
| Sum of active levers in priming session hrs 5-6 | 0.3 | 0.3 | 0.5 | -0.3 | 0.6 | -0.3 | 0.5 | -0.6 | 0.6 | 0.7 | -0.4 |
| Delay discount hyperbolic model param | 0.3 | 0.3 | 0.7 | -0.8 | 0.7 | -0.5 | 0.4 | -0.3 | 0.8 | 0.6 | -0.4 |
| Rest time, locomotor task time 2 | 0.3 | 0.3 | 0.7 | 0.3 | -0.8 | 0.4 | -0.4 | -0.0 | -0.8 | -0.9 | 0.4 |
| Food seeking constrained by brief footshock | 0.3 | 0.4 | 1.2 | -0.2 | 0.7 | -0.1 | -0.1 | -0.5 | 1.1 | 1.0 | -0.0 |
| Cd content in liver | 0.3 | 0.4 | 0.8 | -0.9 | 0.5 | -0.6 | 0.5 | -0.6 | 0.7 | 0.5 | -0.4 |
| Liver weight, left | 0.2 | 0.3 | 0.8 | 0.1 | 0.6 | -0.0 | 0.1 | 0.5 | 0.9 | 0.8 | -0.1 |
| Parametrial fat weight | 0.2 | 0.5 | 0.9 | 0.5 | -0.6 | 0.6 | -0.6 | 0.9 | -0.5 | -0.8 | 0.7 |
| Soleus weight | 0.2 | 0.6 | 1.1 | -0.4 | 0.9 | -0.9 | 0.9 | -0.2 | 0.7 | 1.0 | -0.8 |
| Mean time between licks in bursts | 0.2 | 0.2 | 0.9 | 0.5 | -0.5 | 0.2 | -0.2 | 0.2 | -0.9 | -0.5 | 0.1 |
| Std. dev. reaction times | 0.2 | 0.2 | 0.4 | -0.6 | 0.5 | -0.5 | 0.4 | -0.2 | 0.6 | 0.3 | -0.4 |
| Social time | 0.2 | 0.2 | 1.1 | -0.4 | 0.2 | -0.3 | 0.3 | -1.1 | 0.2 | 0.3 | -0.3 |
| Cocaine response after cond. corrected | 0.2 | 0.2 | 0.4 | 0.6 | -0.3 | 0.5 | -0.6 | 0.3 | -0.2 | -0.2 | 0.4 |
| Cocaine response before conditioning | 0.2 | 0.2 | 0.3 | 0.0 | -0.5 | 0.5 | -0.5 | 0.0 | -0.4 | -0.6 | 0.6 |
| Pavlov. Cond. intertrial magazine entries | 0.2 | 0.2 | 0.9 | 0.7 | -0.4 | 0.3 | -0.3 | 0.9 | -0.1 | -0.2 | 0.4 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 0.4 | -0.4 | 0.5 | -0.4 | 0.6 | -0.1 | 0.6 | 0.5 | -0.4 |
| Lifetime Intake | 0.2 | 0.2 | 0.6 | -0.5 | 0.5 | -0.5 | 0.4 | -0.2 | 0.7 | 0.6 | -0.3 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.2 | 0.5 | -0.5 | 0.5 | -0.5 | 0.3 | -0.3 | 0.7 | 0.6 | -0.2 |
| Short access day 1 locomotion | 0.2 | 0.2 | 0.4 | 0.4 | -0.4 | 0.5 | -0.5 | 0.5 | -0.2 | -0.3 | 0.7 |
| Locomotion velocity, session 1 | 0.2 | 0.2 | 0.4 | 0.1 | -0.3 | 0.7 | -0.6 | -0.4 | -0.2 | -0.3 | 0.5 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.5 | -0.7 | 0.4 | -0.4 | 0.3 | -0.7 | 0.6 | 0.3 | -0.4 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.5 | 0.5 | -0.3 | 0.4 | -0.5 | 0.7 | -0.1 | -0.1 | 0.4 |
| Pavlov. Cond. lever latency | 0.2 | 0.2 | 0.4 | -0.3 | 0.1 | -0.6 | 0.7 | -0.4 | -0.3 | 0.0 | -0.7 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.8 | -0.2 | -0.4 | -0.1 | 0.2 | -0.4 | -0.9 | -0.8 | -0.3 |
| Bone: cortical thickness | 0.2 | 0.2 | 0.5 | -0.6 | 0.4 | -0.4 | 0.5 | -0.7 | 0.2 | 0.3 | -0.5 |
| Bone: maximum moment | 0.2 | 0.4 | 0.7 | -0.5 | 0.8 | -0.5 | 0.5 | -0.3 | 0.7 | 0.8 | -0.7 |
| Bone: tissue strength | 0.2 | 0.2 | 0.6 | -0.3 | 0.5 | -0.2 | 0.1 | -0.2 | 0.7 | 0.5 | -0.2 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | 0.6 | -0.4 | 0.4 | -0.2 | 0.4 | -0.6 | -0.3 | 0.3 |
| Delay disc. indifference point, 8s delay | 0.2 | 0.2 | 0.5 | 0.5 | -0.5 | 0.2 | -0.1 | 0.2 | -0.7 | -0.5 | 0.2 |
| Vertical activity count, locomotor time 1 | 0.2 | 0.2 | 0.3 | -0.4 | 0.6 | -0.4 | 0.5 | -0.2 | 0.5 | 0.5 | -0.4 |
| Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.5 | -0.4 | 0.5 | -0.6 | 0.7 | -0.1 | 0.3 | 0.4 | -0.6 |
| Seeking ratio, delayed vs. immediate footshock | 0.2 | 0.2 | 0.5 | 0.2 | -0.4 | 0.4 | -0.7 | 0.6 | -0.3 | -0.4 | 0.5 |
| Fe content in liver | 0.2 | 0.2 | 0.4 | -0.0 | 0.4 | -0.5 | 0.5 | -0.2 | 0.5 | 0.6 | -0.5 |
| K content in liver | 0.2 | 0.2 | 0.6 | -0.5 | 0.4 | -0.1 | 0.2 | -0.8 | 0.2 | 0.3 | -0.4 |
| Na content in liver | 0.2 | 0.2 | 0.4 | 0.5 | -0.3 | 0.7 | -0.5 | 0.4 | -0.2 | -0.2 | 0.3 |
| Intraocular pressure | 0.1 | 0.2 | 0.6 | -0.2 | 0.3 | -0.6 | 0.7 | -0.2 | -0.1 | 0.2 | -0.8 |
| Extensor digitorum longus weight | 0.1 | 0.6 | 1.3 | -0.7 | 0.7 | -1.1 | 1.0 | -0.2 | 0.5 | 0.5 | -1.0 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.5 | -0.1 | 0.5 | 0.1 | -0.2 | -0.0 | 0.7 | 0.7 | -0.0 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.2 | 0.5 | -0.1 | 0.5 | 0.1 | -0.2 | -0.0 | 0.7 | 0.7 | -0.0 |
| Reaction time trials on left | 0.1 | 0.1 | 0.3 | -0.1 | 0.4 | -0.2 | 0.1 | -0.2 | 0.3 | 0.6 | -0.2 |
| Reaction time mean | 0.1 | 0.1 | 0.2 | -0.3 | 0.2 | -0.4 | 0.3 | 0.0 | 0.4 | 0.2 | -0.2 |
| Reaction time premature initiations | 0.1 | 0.2 | 0.3 | -0.2 | 0.4 | -0.6 | 0.6 | -0.2 | 0.2 | 0.5 | -0.5 |
| Reaction time trials completed | 0.1 | 0.1 | 0.3 | -0.1 | 0.4 | -0.2 | 0.1 | -0.2 | 0.3 | 0.6 | -0.2 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | -0.2 | 0.3 | -0.1 | 0.4 | 0.4 | -0.3 |
| Intermittent access total infusions | 0.1 | 0.1 | 0.4 | -0.2 | 0.4 | -0.3 | 0.1 | 0.0 | 0.6 | 0.5 | -0.0 |
| Locomotion velocity, session 2 | 0.1 | 0.1 | 0.2 | 0.3 | -0.2 | 0.5 | -0.4 | -0.0 | -0.4 | -0.3 | 0.1 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | -0.3 | 0.3 | -0.1 | 0.5 | 0.4 | -0.3 |
| Novel to familiar place preference ratio | 0.1 | 0.1 | 0.4 | 0.5 | -0.2 | 0.4 | -0.4 | 0.6 | 0.1 | -0.0 | 0.3 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.2 | 0.6 | -0.2 | 0.5 | -0.2 | 0.2 | -0.1 | 0.8 | 0.5 | -0.1 |
| Pavlov. Cond. index score | 0.1 | 0.1 | 0.4 | -0.1 | 0.3 | 0.2 | -0.2 | -0.0 | 0.6 | 0.3 | 0.2 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.3 | 0.1 | 0.1 | 0.4 | -0.5 | 0.2 | 0.6 | 0.2 | 0.5 |
| Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.4 | -0.3 | 0.3 | 0.1 | -0.1 | -0.1 | 0.7 | 0.4 | 0.2 |
| Bone: cortical apparent density | 0.1 | 0.2 | 0.8 | -0.6 | 0.0 | -0.2 | 0.2 | -0.9 | 0.1 | -0.1 | -0.1 |
| Bone: cortical tissue density | 0.1 | 0.1 | 0.5 | -0.5 | -0.1 | -0.1 | 0.1 | -0.7 | -0.1 | -0.2 | 0.0 |
| Bone: elastic displacement | 0.1 | 0.1 | 0.4 | -0.4 | -0.2 | -0.3 | 0.2 | -0.2 | -0.7 | -0.5 | -0.3 |
| Extinction: sum of active levers before priming | 0.1 | 0.1 | 0.4 | -0.2 | -0.0 | -0.1 | 0.1 | -0.6 | -0.1 | -0.1 | -0.0 |
| Delta distance traveled before/after self-admin | 0.1 | 0.1 | 0.3 | 0.0 | -0.3 | -0.0 | -0.0 | 0.3 | -0.5 | -0.5 | -0.0 |
| Time in open arm before self-admin | 0.1 | 0.1 | 0.2 | 0.2 | -0.3 | 0.2 | -0.2 | 0.5 | -0.3 | -0.4 | 0.2 |
| Delay disc. indifference point, 4s delay | 0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.0 | 0.1 | -0.2 | -0.5 | -0.3 | -0.1 |
| Distance moved, locomotor task time 2 | 0.1 | 0.2 | 0.4 | 0.6 | -0.1 | 0.5 | -0.5 | 0.5 | -0.1 | 0.0 | 0.5 |
| Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.3 | 0.2 | 0.4 | 0.1 | 0.1 | 0.1 | 0.3 | 0.5 | 0.0 |
| Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.3 | 0.5 | 0.1 | 0.2 | -0.1 | 0.2 | 0.0 | 0.4 | 0.1 |
| Zn content in liver | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | 0.0 | -0.1 | -0.5 | 0.5 | 0.5 | 0.0 |
| Liver weight, right | 0.0 | 0.1 | 0.2 | -0.0 | -0.2 | 0.2 | -0.2 | 0.2 | -0.1 | -0.2 | 0.4 |
| Retroperitoneal fat weight | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.0 | 0.0 | 0.3 | 0.3 | 0.2 | -0.1 |
| Times rat made contact with spout | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.2 | -0.2 | 0.3 | -0.2 | -0.2 | 0.3 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.1 | -0.2 | -0.0 | -0.1 | 0.1 | 0.3 | -0.1 | -0.2 | 0.0 |
| Delay discounting total patch changes 12 sec | 0.0 | 0.0 | 0.0 | -0.1 | -0.0 | 0.1 | -0.2 | -0.1 | -0.1 | -0.0 | -0.0 |
| Locomotor testing distance | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | 0.0 | -0.1 | 0.1 | 0.2 | 0.2 | -0.1 |
| Reaction time number correct | 0.0 | 0.1 | 0.2 | -0.0 | 0.3 | -0.1 | 0.0 | -0.2 | 0.2 | 0.5 | -0.1 |
| Reaction time trials correct on left | 0.0 | 0.1 | 0.2 | -0.0 | 0.3 | -0.1 | 0.0 | -0.2 | 0.2 | 0.5 | -0.1 |
| Reaction time mean AUC | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | -0.3 | 0.3 | 0.0 | 0.3 | 0.2 | -0.2 |
| Reaction time trials AUC | 0.0 | 0.1 | 0.3 | -0.1 | 0.3 | -0.2 | 0.1 | -0.2 | 0.2 | 0.5 | -0.2 |
| Incentive Sensitization - Responses | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 | 0.0 | 0.0 | -0.1 |
| Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 | 0.2 | -0.0 | -0.1 | 0.1 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | -0.3 | 0.0 | -0.3 | 0.2 | 0.0 | 0.1 | -0.1 | 0.0 |
| Short access day 1 total infusions | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 | 0.1 | 0.1 | -0.0 | 0.1 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.1 | -0.1 | 0.3 | -0.1 | -0.2 | 0.2 |
| Short access total infusions | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | -0.2 | 0.1 | 0.0 | 0.2 | 0.0 | -0.0 |
| Number of responses in last shaping day | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | -0.2 | 0.4 | -0.2 | -0.2 | 0.1 |
| Stereotopy head waving bouts, day 7 | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | -0.1 | 0.1 | -0.4 | -0.3 | -0.2 | -0.2 |
| Condit. Reinf. inactive responses | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.4 | -0.3 | 0.2 | 0.0 | -0.1 | 0.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.1 | 0.3 | -0.1 | 0.2 | 0.1 | -0.1 | -0.0 | 0.5 | 0.2 | 0.2 |
| Bone: elastic work | 0.0 | 0.1 | 0.1 | -0.4 | 0.0 | -0.3 | 0.2 | -0.3 | -0.2 | -0.2 | -0.3 |
| Time to tail flick, vehicle, after self-admin | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.2 | 0.3 | 0.3 | -0.1 | -0.0 | -0.2 |
| Fecal boli incidents, locomotor time 1 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | -0.1 | 0.2 | -0.2 | -0.3 | -0.3 | -0.1 |
| Change in fecal boli incidents, locomotor task | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 | 0.2 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.0 | -0.2 | 0.2 | -0.1 | 0.1 | -0.1 | 0.2 | 0.1 | -0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.