Hub : Genes

ENSRNOG00000067947

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000067947 0.06 0.05 1.1e-03 0.03 0.02 0.02 0.01 6.9e-03 4.3e-02 2.3e-02 8.5e-02
2 IL gene expression ENSRNOG00000067947 0.16 0.12 3.2e-03 0.01 0.08 0.04 -0 2.1e-01 5.8e-03 3.8e-02 4.2e-01
3 OFC gene expression ENSRNOG00000067947 0.15 0.12 6.9e-03 0.09 0.07 0.09 0.1 3.2e-03 1.2e-02 3.4e-03 2.9e-03
4 NAcc gene expression ENSRNOG00000067947 0.2 0.11 1.7e-16 0.2 0.2 0.2 0.2 1.6e-14 6.4e-15 7.6e-15 5.8e-15
5 Brain gene expression ENSRNOG00000067947 0.08 0.06 2.9e-08 0.08 0.09 0.08 0.08 4.7e-08 2.8e-08 3.2e-08 7.1e-08
6 PL gene expression ENSRNOG00000067947 0.14 0.07 1.2e-14 0.16 0.16 0.14 0.16 1.8e-12 5.5e-12 1.6e-10 2.7e-12
7 Adipose gene expression ENSRNOG00000067947 0.12 0.08 1.7e-14 0.09 0.1 0.11 0.09 2.1e-10 1.1e-10 4.1e-12 2.1e-10
8 Liver gene expression ENSRNOG00000067947 0.15 0.11 7.3e-14 0.09 0.08 0.1 0.09 3.9e-10 5.1e-09 8.0e-11 6.7e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.62.6-1.6-1.1-1.5-1.3-1.4-1.60.50.7
Area under the delay curve1.51.62.21.51.21.41.31.21.4-1.2-0.9
BMI with tail2.68.511.6-2.9-3.4-2.6-3.3-3.0-3.22.91.8
BMI without tail1.63.35.2-2.2-2.3-1.7-1.9-1.9-1.91.60.7
Body weight0.41.72.9-1.3-1.7-0.9-1.5-1.3-1.51.40.4
Weight adjusted by age1.51.72.3-1.5-1.5-1.3-1.4-1.5-1.40.90.8
Bone surface0.81.42.3-1.5-1.2-1.5-1.2-1.3-1.30.70.5
Bone volume1.32.33.4-1.8-1.5-1.7-1.5-1.6-1.80.80.8
Breakpoint value in progressive ratio session1.21.32.4-1.5-1.2-1.6-1.0-1.1-1.01.00.2
Number of licking bursts0.10.10.20.50.20.40.50.40.1-0.2-0.3
Context. condit. distance diff. score0.10.10.4-0.30.6-0.1-0.00.20.40.10.4
Locomotion velocity, session 10.00.00.10.40.10.10.1-0.1-0.2-0.30.1
Locomotion distance, session 11.01.41.91.21.11.31.21.21.4-0.9-0.9
Locomotion velocity, session 20.70.81.21.11.00.81.00.91.0-0.7-0.6
Locomotion distance, session 20.60.91.11.00.91.01.11.01.1-0.7-0.7
Locomotion velocity, session 30.00.00.1-0.3-0.1-0.3-0.2-0.2-0.10.20.1
Locomotion distance, session 30.10.10.30.60.20.10.30.30.6-0.1-0.4
Stereotopy head waving bouts, day 30.00.00.1-0.2-0.3-0.2-0.3-0.2-0.20.20.1
Stereotopy head waving duration, day 30.20.20.40.30.40.60.40.50.4-0.4-0.4
Locomotion velocity, session 72.72.93.61.61.61.81.81.91.9-1.3-1.8
Locomotion distance, session 73.24.05.12.12.12.22.22.32.2-1.4-1.4
Stereotopy head waving bouts, day 71.31.41.91.01.41.01.21.21.3-1.2-1.2
Stereotopy head waving duration, day 70.50.60.90.51.00.60.70.70.8-0.9-0.8
Locomotion velocity, session 80.50.51.10.90.60.60.70.61.0-0.5-0.8
Locomotion distance, session 81.01.52.80.91.71.21.31.41.6-0.8-0.3
Degree of sensitization distance1.81.93.01.31.51.71.51.51.2-1.1-0.9
Degree of sensitization stereotypy1.41.62.11.01.41.01.31.31.4-1.2-1.2
Conditioned locomotion0.40.40.9-0.5-0.9-0.7-0.6-0.8-0.60.60.4
Cocaine response after cond. corrected0.10.10.40.40.50.40.20.20.1-0.60.1
Cocaine response after cond. not corrected0.00.00.20.10.2-0.0-0.1-0.1-0.3-0.40.1
Cocaine response before conditioning1.41.82.5-1.5-1.3-1.6-1.4-1.3-1.41.30.7
Saline control response0.10.20.4-0.3-0.3-0.6-0.3-0.4-0.40.40.6
Bone: connectivity density0.91.42.7-1.6-0.9-1.6-1.2-1.3-1.20.40.4
Bone: cortical apparent density0.40.51.41.20.11.20.70.60.3-0.0-0.1
Bone: cortical area3.55.37.1-2.7-2.5-2.6-2.4-2.4-2.12.01.5
Bone: cortical porosity0.70.71.1-1.0-1.0-1.0-0.8-0.9-0.50.90.5
Bone: cortical porosity0.91.01.6-1.3-1.1-1.2-0.9-1.0-0.61.00.7
Bone: cortical thickness2.64.25.7-2.4-2.3-2.4-2.1-2.2-1.91.81.3
Bone: cortical thickness0.30.30.5-0.5-0.6-0.7-0.7-0.7-0.70.10.3
Bone: cortical tissue density0.40.61.71.30.11.30.80.60.4-0.1-0.1
Condit. Reinf. active minus inactive responses0.20.20.5-0.7-0.6-0.5-0.2-0.4-0.40.2-0.2
Condit. Reinf. active-inactive response ratio0.20.20.4-0.6-0.6-0.3-0.3-0.4-0.50.30.1
Condit. Reinf. active responses0.60.81.4-1.2-1.1-1.0-0.7-1.0-0.80.60.2
Condit. Reinf. inactive responses0.40.40.6-0.8-0.8-0.7-0.6-0.8-0.60.50.4
Incentive salience index mean0.10.20.4-0.5-0.6-0.4-0.0-0.3-0.2-0.0-0.6
Condit. Reinf. lever presses0.10.10.3-0.2-0.5-0.6-0.1-0.4-0.4-0.2-0.5
Condit. Reinf. active minus inactive responses0.00.00.20.40.2-0.1-0.2-0.0-0.00.00.4
Condit. Reinf. active-inactive response ratio0.80.81.71.31.10.80.80.91.1-0.7-0.4
Condit. Reinf. active responses0.20.30.5-0.4-0.4-0.7-0.6-0.6-0.70.50.7
Condit. Reinf. inactive responses2.12.63.7-1.7-1.7-1.6-1.5-1.6-1.91.41.3
Condit. Reinf. lever presses0.40.60.9-0.9-0.8-0.8-0.7-0.7-0.71.00.4
Condit. Reinf. lever reinforcers received0.60.91.1-0.8-0.8-1.1-1.0-0.9-1.10.81.0
Conditioned reinforcement - actives1.21.22.0-0.7-1.1-0.5-1.3-1.0-1.41.11.2
Conditioned reinforcement - inactives0.40.50.8-0.7-0.5-0.3-0.9-0.6-0.90.60.7
Conditioned locomotion0.20.30.6-0.2-0.4-0.2-0.7-0.4-0.80.40.6
Patch foraging indifference point 0 sec0.10.10.50.20.40.4-0.10.2-0.40.20.7
Patch foraging indifference point AUC0.20.30.80.10.10.20.70.50.9-0.2-0.8
Delay disc. indifference point, 0s delay2.12.33.61.91.31.91.61.51.5-1.2-1.1
Delay disc. indifference point, 16s delay1.31.32.21.20.81.21.41.11.5-0.8-0.9
Delay disc. indifference point, 2s delay0.20.20.50.30.70.30.30.30.4-0.7-0.2
Delay disc. indifference point, 24s delay1.61.53.31.70.91.81.11.21.1-0.8-0.6
Delay disc. indifference point, 4s delay0.70.81.31.10.81.10.90.80.9-0.8-0.5
Delay disc. indifference point, 8s delay0.10.10.20.30.40.20.20.20.3-0.4-0.1
Indifference point function ln k0.30.41.11.00.70.90.30.4-0.0-0.40.4
Indifference point function log k0.30.41.11.00.70.90.30.4-0.0-0.40.4
Patch foraging total patch changes 0 sec0.10.10.40.20.60.50.10.4-0.1-0.10.5
Patch foraging total patch changes 12 sec0.30.41.00.61.00.40.70.80.7-0.4-0.1
Patch foraging total patch changes 18 sec0.00.00.2-0.20.2-0.10.10.20.4-0.0-0.1
Patch foraging total patch changes 24 sec0.60.71.20.90.70.81.01.01.1-0.3-0.5
Patch foraging total patch changes 6 sec0.20.40.60.40.70.70.70.80.7-0.4-0.3
Patch foraging time to switch 0 sec0.10.20.8-0.40.2-0.9-0.4-0.4-0.3-0.20.2
Patch foraging water rate 0 sec0.20.30.60.80.10.80.40.50.5-0.1-0.3
Patch foraging water rate 12 sec0.10.10.40.2-0.60.2-0.2-0.3-0.10.4-0.0
Patch foraging water rate 18 sec0.20.31.00.4-1.00.1-0.3-0.4-0.40.7-0.1
Patch foraging water rate 24 sec0.20.30.80.90.10.80.60.50.6-0.1-0.5
Patch foraging water rate 6 sec0.20.31.0-0.0-1.0-0.3-0.4-0.4-0.40.7-0.4
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.3-0.6-0.1-0.0-0.30.0-0.0-0.4
Distance traveled before self-admin1.11.23.4-0.5-1.0-0.4-1.1-1.0-1.30.91.8
Distance traveled after self-admin0.00.00.20.2-0.40.0-0.1-0.3-0.3-0.1-0.1
Extensor digitorum longus weight0.52.14.0-1.6-2.0-1.5-1.3-1.5-1.11.60.8
Bone: elastic displacement0.20.20.7-0.5-0.8-0.1-0.0-0.2-0.10.6-0.5
Bone: elastic work0.91.22.6-1.5-1.6-0.9-0.8-1.0-0.81.20.0
Bone: endosteal estimation0.10.10.3-0.4-0.1-0.5-0.5-0.3-0.30.10.2
Bone: endosteal perimeter0.00.10.1-0.4-0.2-0.3-0.2-0.2-0.00.2-0.0
Epididymis fat weight0.10.30.6-0.4-0.8-0.2-0.7-0.6-0.70.40.3
Delta time in closed arm before/after self-admin1.00.91.9-0.8-1.4-0.6-1.0-1.0-1.00.80.9
Delta time in open arm before/after self-admin5.95.68.52.02.91.92.72.62.5-2.1-2.0
Diff in mean of infusions in LGA sessions0.00.00.20.0-0.20.1-0.10.00.10.50.2
Delay discount exponential model param1.31.42.0-1.4-1.2-1.4-1.2-1.1-1.21.10.8
Extinction: sum of active levers before priming0.10.10.2-0.3-0.2-0.20.10.00.20.50.0
Active lever presses in extinction session 60.40.40.9-0.7-0.9-0.7-0.4-0.6-0.21.00.4
Bone: final force1.52.43.3-1.7-1.8-1.5-1.7-1.6-1.41.41.0
Bone: final moment1.22.03.0-1.6-1.7-1.4-1.5-1.5-1.21.40.9
Food consumed during 24 hour testing period2.83.46.0-1.7-2.4-1.7-1.7-1.9-1.82.11.1
Glucose2.94.45.9-2.4-1.9-2.2-2.4-2.1-2.21.81.8
Heart weight0.70.91.6-1.3-1.3-1.1-0.7-1.0-0.51.00.5
Delay discount hyperbolic model param1.21.21.6-1.3-1.2-1.2-1.1-1.1-1.11.10.7
Intermittent access intake day 1-15 change0.10.10.40.4-0.10.6-0.1-0.0-0.10.00.4
Intermittent access intake escalation0.00.00.20.3-0.20.50.00.00.00.00.1
Intermittent access intake escalation 20.10.10.30.50.30.60.10.10.1-0.30.3
Intermitt. access day 1 inactive lever presses0.40.51.01.00.31.00.70.50.7-0.5-0.5
Intermitt. access day 15 inactive lever presses0.00.00.10.10.10.10.20.00.2-0.4-0.0
Intermitt. access escalation Index1.81.64.5-2.1-0.3-2.1-1.3-1.0-1.10.40.2
Intermittent access day 1 total infusions0.10.10.50.30.20.10.20.40.1-0.0-0.7
Intermittent access day 15 total infusions0.10.20.40.60.20.60.30.40.2-0.2-0.4
Intermittent access terminal intake (last 3 days)0.00.00.10.2-0.10.1-0.00.1-0.1-0.0-0.2
Intermittent access total infusions0.10.20.4-0.2-0.6-0.3-0.3-0.2-0.40.4-0.5
Intermittent access day 1 locomotion0.00.00.1-0.0-0.1-0.1-0.10.0-0.20.0-0.4
Intermittent access day 15 total locomotion0.70.81.6-0.4-1.2-0.4-1.0-1.0-1.30.60.6
Intermittent access total locomotion0.10.10.50.0-0.70.1-0.2-0.3-0.40.2-0.1
Intermittent access standard deviation0.10.10.2-0.1-0.5-0.1-0.3-0.3-0.20.30.3
Left kidney weight0.10.30.5-0.7-0.1-0.7-0.6-0.5-0.60.40.5
Right kidney weight0.00.00.1-0.20.4-0.1-0.00.10.10.10.2
Cocaine induced anxiety4.95.77.12.12.71.92.52.42.6-2.6-2.3
Post-drug Anxiety2.73.04.31.31.91.21.71.61.8-2.1-2.1
Baseline Anxiety1.01.11.7-1.0-1.3-1.1-1.1-1.1-1.11.10.4
Tail length1.13.44.31.22.11.72.02.02.0-1.8-1.8
Length with tail0.41.51.71.11.31.21.31.31.3-1.1-1.1
Length without tail0.10.10.30.50.20.40.20.30.4-0.1-0.4
Times rat made contact with spout0.40.50.70.40.80.30.80.70.7-0.7-0.8
Lifetime Intake0.20.20.4-0.2-0.6-0.4-0.3-0.2-0.40.4-0.6
Liver weight, left1.72.83.7-1.7-1.9-1.5-1.9-1.8-1.91.31.2
Liver weight, right1.62.73.4-1.2-1.7-1.4-1.8-1.7-1.81.51.6
Locomotor activity1.11.84.0-1.4-2.0-0.9-1.2-1.5-1.41.21.0
Locomotor testing distance0.91.43.4-1.2-1.8-0.9-1.0-1.3-1.11.10.7
Locomotor testing rearing0.20.30.5-0.6-0.7-0.4-0.3-0.5-0.50.40.6
Locomotion in novel chamber0.20.30.50.5-0.70.30.70.00.7-0.0-0.6
Locomotion in novel chamber post-restriction0.00.10.2-0.30.3-0.4-0.0-0.00.0-0.3-0.1
Fecal boli incidents, locomotor time 10.91.01.70.51.00.51.01.01.2-1.1-1.3
Change in fecal boli incidents, locomotor task0.20.20.5-0.1-0.50.0-0.1-0.2-0.20.70.7
Time >=10cm from walls, locomotor time 10.20.20.8-0.5-0.0-0.9-0.1-0.2-0.0-0.1-0.7
Bouts of movement, locomotor time 10.40.41.30.41.20.20.60.60.6-0.9-0.2
Total resting periods, locomotor time 10.50.51.70.31.30.20.70.70.7-1.0-0.3
Rest time, locomotor task time 10.10.10.4-0.50.1-0.7-0.1-0.1-0.10.2-0.0
Distance moved, locomotor task time 10.91.02.31.40.51.51.00.91.0-0.7-0.7
Vertical activity count, locomotor time 11.11.21.91.30.91.41.11.01.1-1.0-0.8
Time >=10cm from walls, locomotor time 20.50.60.90.60.90.30.80.81.0-0.6-0.8
Bouts of movement, locomotor time 22.22.43.21.81.81.81.51.81.4-1.2-0.8
Total resting periods, locomotor time 21.21.32.41.31.51.30.91.30.9-0.9-0.3
Rest time, locomotor task time 20.10.10.60.30.8-0.10.10.30.1-0.5-0.1
Distance moved, locomotor task time 20.20.20.40.5-0.30.50.50.20.50.1-0.6
Vertical activity count, locomotor time 20.30.30.60.70.30.80.60.50.5-0.3-0.5
Light reinforcement 10.10.20.50.20.20.20.40.40.7-0.3-0.5
Light reinforcement 20.50.61.40.71.20.60.70.80.8-0.9-0.6
Bone: marrow area0.10.20.4-0.6-0.3-0.7-0.6-0.5-0.40.20.3
Bone: maximum diameter4.88.711.3-3.2-2.9-3.4-3.2-3.1-3.02.52.1
Bone: maximum force1.12.02.7-1.6-1.6-1.4-1.5-1.4-1.21.30.9
Bone: maximum moment1.01.72.5-1.5-1.6-1.3-1.4-1.3-1.01.30.8
Mean time between licks in bursts0.20.30.80.70.70.90.50.60.4-0.30.1
Mean num. licks in bursts0.10.10.2-0.10.4-0.10.20.20.5-0.4-0.4
Cd content in liver1.31.42.0-1.1-0.8-1.4-1.4-1.3-1.30.81.4
Co content in liver5.26.17.62.62.82.62.42.62.6-2.3-1.7
Cu content in liver0.10.10.30.2-0.50.30.2-0.00.20.4-0.2
Fe content in liver0.00.10.1-0.2-0.2-0.3-0.3-0.3-0.20.00.2
K content in liver1.01.02.00.90.70.91.01.01.2-0.9-1.4
Mg content in liver1.01.01.40.90.61.21.01.01.1-0.8-1.2
Mn content in liver1.41.62.51.10.91.21.41.21.4-1.0-1.6
Na content in liver0.20.21.10.3-0.30.10.30.10.4-0.2-1.1
Rb content in liver1.11.43.1-1.0-1.8-1.0-1.2-1.3-1.21.20.6
Se content in liver1.72.02.41.51.31.61.51.51.5-1.3-1.2
Sr content in liver0.10.10.20.30.40.20.20.30.3-0.3-0.0
Zn content in liver0.70.81.2-0.7-0.6-0.7-1.0-0.8-0.90.91.1
Bone: minimum diameter0.20.40.7-0.8-0.5-0.7-0.6-0.6-0.40.60.6
Time in familiar zone, hab. session 11.31.21.81.30.71.21.31.11.0-0.7-1.1
Time in novel zone, hab. session 11.71.62.5-1.6-0.9-1.6-1.5-1.3-1.10.81.1
Total zone transitions, hab. session 12.23.14.61.91.21.82.01.81.7-1.4-2.1
Total locomotion distance, hab. session 10.71.01.51.20.71.21.11.00.8-0.8-1.0
Locomotion velocity, hab. session 10.60.91.31.10.61.21.01.00.8-0.7-1.0
Time in familiar zone, hab. session 20.20.20.40.60.60.70.40.60.4-0.2-0.0
Time in novel zone, hab. session 20.20.20.5-0.7-0.4-0.4-0.3-0.5-0.30.10.0
Total zone transitions, hab. session 20.30.40.91.00.40.60.90.60.7-0.3-0.5
Total locomotion distance, hab. session 20.30.40.70.60.40.70.80.60.8-0.3-0.5
Locomotion velocity, hab. session 20.30.40.80.70.40.70.80.70.9-0.4-0.5
Novel to familiar place preference ratio0.40.40.9-0.10.50.50.90.60.7-0.5-0.8
Novelty place preference0.30.30.6-0.30.40.30.80.50.7-0.4-0.7
Time in novel zone, NPP test0.10.10.3-0.60.10.10.60.20.4-0.2-0.5
Total zone transitions, NPP test0.20.31.01.00.10.60.80.50.5-0.2-0.5
Total locomotion distance, NPP test0.70.91.61.00.71.11.31.01.1-0.7-0.7
Locomotion velocity, NPP test1.01.42.31.30.91.41.51.21.3-0.9-0.9
Intraocular pressure1.52.12.91.51.51.71.61.51.4-1.4-1.0
Delta distance traveled before/after self-admin0.20.21.40.10.0-0.00.30.10.4-0.4-1.2
Delta ambulatory time before/after self-admin0.30.31.80.20.3-0.10.20.30.3-0.5-1.3
Parametrial fat weight1.12.23.0-1.5-1.6-1.7-1.7-1.7-1.51.20.8
Pavlov. Cond. lever latency0.50.61.0-0.7-0.5-0.6-0.9-0.8-1.00.60.9
Pavlov. Cond. magazine entry latency0.70.91.21.00.91.01.11.01.1-0.7-0.8
Pavlov. Cond. change in total contacts1.31.42.11.30.81.21.31.21.3-0.9-1.4
Pavlov. Cond. index score0.50.70.90.90.50.70.90.81.0-0.6-1.0
Pavlov. Cond. latency score0.60.71.10.80.60.71.00.81.0-0.7-0.9
Pavlov. Cond. lever contacts0.10.10.20.3-0.10.00.30.10.4-0.2-0.5
Pavlov. Cond. magazine entry number0.00.10.1-0.30.0-0.1-0.2-0.2-0.30.00.4
Pavlov. Cond. intertrial magazine entries2.22.73.9-2.0-1.8-1.8-1.6-1.8-1.51.31.1
Pavlov. Cond. lever-magazine prob. diff.0.60.71.11.00.40.81.00.81.0-0.6-1.0
Pavlov. Cond. response bias0.00.00.10.1-0.1-0.10.1-0.00.2-0.0-0.3
Pavlov. Cond. lever latency0.30.50.80.60.60.80.70.60.5-0.9-0.6
Pavlov. Cond. magazine entry latency0.10.10.3-0.3-0.6-0.1-0.4-0.3-0.20.50.1
Pavlov. Cond. change in total contacts0.40.61.2-0.5-1.1-0.7-0.8-0.8-0.81.00.5
Pavlov. Cond. index score0.20.20.5-0.3-0.6-0.4-0.5-0.4-0.30.70.3
Pavlov. Cond. latency score0.20.30.6-0.4-0.7-0.5-0.6-0.5-0.40.80.3
Pavlov. Cond. lever contacts0.20.20.6-0.5-0.5-0.5-0.4-0.3-0.30.80.4
Pavlov. Cond. magazine entry number0.30.30.90.30.90.40.50.60.5-0.7-0.1
Pavlov. Cond. intertrial magazine entries0.40.50.8-0.6-0.6-0.9-0.7-0.8-0.80.50.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.1-0.5-0.2-0.3-0.2-0.10.50.0
Pavlov. Cond. response bias0.00.10.3-0.1-0.3-0.1-0.1-0.1-0.10.50.2
Time in closed arm before self-admin1.61.92.61.61.11.41.61.31.5-1.2-1.2
Time in closed arm after self-admin0.30.31.2-0.3-1.1-0.4-0.4-0.8-0.50.30.3
Time in open arm before self-admin2.42.54.0-1.5-1.6-1.3-2.0-1.6-1.81.41.3
Time in open arm after self-admin0.80.91.60.71.30.81.11.11.0-0.6-0.8
Bone: periosteal estimation1.32.73.8-1.9-1.6-2.0-1.8-1.7-1.51.31.1
Bone: periosteal perimeter0.30.61.0-1.0-0.8-1.0-0.7-0.8-0.50.80.3
Bone: post-yield work0.30.40.7-0.80.1-0.7-0.7-0.4-0.50.30.8
Progressive ratio test 1 active lever presses0.80.81.61.20.61.10.81.00.7-0.6-1.3
Progressive ratio test 1 breakpoint0.80.91.61.20.61.00.70.90.6-0.7-1.3
Progressive ratio test 1 inactive lever presses0.70.71.31.10.51.20.60.90.7-0.7-1.0
Progressive ratio test 2 active lever presses0.30.30.60.80.40.70.30.50.2-0.4-0.8
Progressive ratio test 2 breakpoint0.20.20.60.80.30.70.20.50.1-0.4-0.7
Progressive ratio test 2 inactive lever presses0.60.71.30.80.31.00.80.80.9-0.6-1.1
Incentive Sensitization - Responses1.11.12.01.41.01.40.81.10.8-1.0-0.7
Incentive Sensitization - Breakpoint0.70.71.41.10.81.20.60.80.5-0.8-0.6
Sum of active levers in priming session hrs 5-60.70.71.3-1.1-0.5-1.2-0.7-0.8-0.70.80.6
Progressive ratio0.70.81.6-1.1-1.3-1.0-0.7-1.1-0.70.70.3
Food seeking constrained by brief footshock0.81.02.0-1.3-0.5-1.4-1.0-0.9-0.90.80.7
Seeking ratio, punishment vs. effort0.10.10.60.30.80.20.10.40.1-0.20.3
Retroperitoneal fat weight0.93.14.6-2.0-1.9-2.1-1.9-1.9-1.61.50.8
Reaction time number correct0.71.01.6-1.1-0.7-1.2-1.1-1.1-1.00.61.0
Reaction time mean minus median2.43.14.12.01.81.91.82.01.9-1.2-1.1
Reaction time mean minus median AUC1.21.52.51.61.31.41.31.41.3-0.7-0.5
Reaction time num false alarms0.00.00.1-0.1-0.10.0-0.20.00.10.1-0.1
Reaction time num false alarms AUC0.10.10.3-0.4-0.4-0.3-0.6-0.3-0.30.40.3
Reaction time trials correct on left0.71.01.6-1.1-0.7-1.2-1.1-1.1-1.00.61.0
Reaction time trials on left0.71.01.6-1.1-0.8-1.3-1.1-1.1-1.00.61.0
Reaction time mean1.11.52.31.41.31.51.31.41.2-0.9-0.8
Reaction time mean AUC0.81.11.61.31.11.31.11.20.9-0.8-0.7
Median of all reaction times1.01.32.11.31.11.51.21.21.0-0.9-0.8
Reaction time omissions0.10.20.80.90.20.60.20.40.20.0-0.2
Reaction time false alarm rate0.10.10.20.20.00.40.20.30.30.0-0.4
Reaction time premature initiation rate0.20.30.60.70.50.50.80.50.6-0.2-0.1
Reaction time premature initiations0.00.00.10.30.3-0.00.30.10.2-0.10.3
Std. dev. reaction times3.24.45.92.42.42.22.22.42.2-1.4-1.2
Reaction time trials completed0.71.01.6-1.1-0.8-1.3-1.1-1.1-1.00.61.0
Reaction time trials AUC0.71.01.5-1.1-0.7-1.2-1.1-1.0-1.00.60.9
Run reversals in cocaine runway, females0.90.91.11.10.70.91.00.81.0-0.9-1.0
Run reversals in cocaine runway, males0.90.91.6-0.7-1.2-0.6-0.9-1.1-0.80.91.1
Latency to leave start box in cocaine runway0.10.10.6-0.7-0.0-0.7-0.3-0.2-0.20.10.0
Latency to leave start box in cocaine runway, F0.10.10.7-0.10.80.00.10.40.1-0.5-0.2
Latency to leave start box in cocaine runway, M0.80.71.3-0.8-1.1-0.8-0.7-0.8-0.71.00.8
Std. dev. time between licks in bursts1.31.52.41.31.31.51.51.31.1-1.0-0.6
Total sessions with >9 infusions0.40.40.90.9-0.21.00.60.50.4-0.2-1.0
Short access day 1 total inactive lever presses0.10.10.40.40.20.20.30.50.4-0.0-0.6
Short access day 10 total inactive lever presses0.30.41.0-0.5-1.0-0.7-0.4-0.7-0.50.50.1
Short access day 1 total infusions0.30.30.6-0.5-0.8-0.6-0.4-0.5-0.50.5-0.1
Short access day 10 total infusions0.20.20.4-0.2-0.7-0.3-0.4-0.3-0.40.4-0.5
Short access total infusions0.10.10.60.0-0.5-0.1-0.00.0-0.10.3-0.8
Short access day 1 locomotion0.30.31.3-0.1-1.1-0.1-0.3-0.6-0.40.50.2
Short access day 10 total locomotion0.10.10.6-0.0-0.8-0.1-0.3-0.5-0.30.10.2
Short access total locomotion0.10.10.70.2-0.80.3-0.0-0.3-0.20.0-0.4
One hour access (0.3 mA shock)0.20.20.7-0.1-0.2-0.2-0.7-0.4-0.80.00.1
Compulsive drug intake1.11.11.7-1.3-0.6-1.2-1.2-1.1-1.20.41.0
One hour access (shock baseline)0.10.20.4-0.1-0.6-0.2-0.5-0.4-0.60.3-0.1
Social response proportion0.70.81.9-1.4-0.7-0.8-0.9-0.9-1.10.60.5
Social responses1.52.02.5-1.5-1.6-1.3-1.4-1.5-1.61.21.1
Social time0.10.10.4-0.50.2-0.2-0.2-0.1-0.1-0.00.6
Soleus weight1.54.46.8-2.6-2.4-2.3-2.2-2.3-1.91.61.1
Bone: stiffness0.81.31.6-1.2-1.2-1.2-1.3-1.2-0.91.01.0
Tibialis anterior weight1.65.68.6-2.3-2.9-2.5-2.4-2.6-2.22.21.5
Time to tail flick, vehicle, before self-admin3.23.34.1-1.9-1.4-1.9-2.0-1.9-2.01.21.9
Time to tail flick, vehicle, after self-admin0.00.00.10.0-0.00.20.20.20.40.30.1
Time to tail flick, test, before self-admin0.90.91.11.01.01.11.00.80.9-1.1-0.6
Time to tail flick, test, after self-admin0.20.20.5-0.1-0.70.20.1-0.3-0.20.60.4
Delta time to tail flick, vehicle, before/after SA2.62.63.81.61.31.71.81.81.9-0.9-1.4
Delta time to tail flick, test, before/after SA2.72.43.3-1.7-1.8-1.5-1.4-1.5-1.51.81.1
Tibia length3.510.012.93.03.43.13.33.43.6-2.6-2.6
Ambulatory time before self-admin1.81.94.3-1.0-1.2-0.9-1.5-1.4-1.51.12.1
Ambulatory time after self-admin0.20.30.6-0.2-0.8-0.4-0.5-0.7-0.70.0-0.1
Bone: tissue strength0.80.71.4-1.0-1.2-0.8-0.8-0.7-0.61.20.2
Total heroin consumption0.50.61.3-1.1-0.0-1.1-0.7-0.7-0.60.51.0
Bone: trabecular number0.61.01.6-1.1-1.0-1.3-1.0-1.1-1.30.40.5
Bone: trabecular spacing0.00.00.1-0.4-0.0-0.10.0-0.1-0.00.10.3
Bone: trabecular thickness1.41.62.4-1.5-0.9-1.6-1.5-1.3-1.40.71.0
Bone: trabecular tissue density0.10.10.40.1-0.60.0-0.2-0.3-0.00.3-0.1
Water consumed over 24 hours0.10.10.2-0.1-0.40.10.30.00.00.3-0.4
Number of responses in last shaping day1.51.53.31.80.81.81.21.21.0-0.8-0.8