Selenow

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000067799	0.34	0.17	7.3e-15	0.13	0.13	0.12	0.12	2.4e-14	8.1e-14	1.0e-12	8.9e-14
2	Brain	gene expression	ENSRNOG00000067799	0.07	0.05	3.4e-07	0.08	0.07	0.07	0.07	8.0e-08	4.3e-07	9.3e-07	5.3e-07
3	Liver	gene expression	ENSRNOG00000067799	0.66	0.12	0.0e+00	0.23	0.24	0.24	0.23	4.4e-25	2.1e-26	2.8e-26	7.3e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.8	2.7	4.0	2.0	-2.0	0.6
BMI without tail	1.8	3.7	5.2	2.3	-2.2	1.1
Body weight	1.3	5.7	7.2	2.7	-2.1	2.3
Epididymis fat weight	0.9	2.1	3.7	-1.1	1.2	-1.9
Glucose	1.9	2.9	3.9	-1.5	1.6	-2.0
Heart weight	0.8	1.1	2.1	0.5	-1.4	1.0
Left kidney weight	7.7	22.1	30.8	4.4	-4.0	5.5
Right kidney weight	4.9	13.9	17.2	3.5	-3.5	4.1
Tail length	0.5	1.4	2.5	1.1	-0.8	1.6
Length with tail	0.7	2.5	5.6	1.2	-0.7	2.4
Length without tail	0.3	0.8	1.8	0.6	-0.2	1.4
Liver weight, left	11.1	17.9	21.2	4.6	-4.2	3.9
Liver weight, right	3.1	5.1	6.7	2.3	-2.6	1.8
Parametrial fat weight	0.9	1.7	5.1	-0.3	-0.0	-2.3
Retroperitoneal fat weight	0.9	3.1	8.8	-0.5	0.6	-3.0
Intraocular pressure	0.2	0.3	0.6	-0.5	0.8	-0.3
Extensor digitorum longus weight	1.5	5.9	7.2	2.4	-2.1	2.7
Soleus weight	0.3	0.8	0.9	0.9	-0.9	0.8
Tibialis anterior weight	2.3	7.9	10.3	3.2	-3.1	1.9
Tibia length	2.0	5.7	11.3	1.7	-1.6	3.4
Number of licking bursts	2.3	2.7	3.2	1.7	-1.8	1.4
Food consumed during 24 hour testing period	3.1	3.8	5.6	-1.9	2.4	-1.5
Times rat made contact with spout	0.6	0.7	1.0	-0.7	1.0	-0.7
Mean time between licks in bursts	0.1	0.1	0.1	0.3	-0.3	-0.2
Mean num. licks in bursts	3.8	4.6	6.1	-2.1	2.5	-1.8
Std. dev. time between licks in bursts	0.8	1.0	1.2	1.0	-0.9	1.1
Water consumed over 24 hours	0.5	0.6	1.2	-0.7	1.1	-0.1
Indifference point 0 sec	0.0	0.1	0.1	0.2	-0.3	-0.3
Indifference point AUC	3.0	3.5	4.6	2.2	-1.8	1.7
Indifference point function ln k	2.1	3.0	5.2	-2.3	1.9	-0.6
Indifference point function log k	2.1	3.0	5.2	-2.3	1.9	-0.6
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.3	-0.4	-0.2
Delay discounting total patch changes 12 sec	1.3	1.7	2.5	1.6	-1.3	1.0
Delay discounting total patch changes 18 sec	1.4	1.8	2.7	1.6	-1.2	1.1
Delay discounting total patch changes 24 sec	1.7	2.2	2.8	1.7	-1.3	1.4
Delay discounting total patch changes 6 sec	1.0	1.5	2.5	1.6	-1.3	0.6
Delay discounting time to switch 0 sec	2.6	4.0	8.2	-1.2	1.5	-2.9
Delay discounting water rate 0 sec	2.0	3.2	5.1	1.5	-1.5	2.3
Delay discounting water rate 12 sec	0.2	0.3	0.7	-0.3	0.1	0.8
Delay discounting water rate 18 sec	0.1	0.1	0.1	-0.3	0.1	0.3
Delay discounting water rate 24 sec	0.2	0.2	0.4	-0.6	0.5	0.3
Delay discounting water rate 6 sec	2.9	4.2	8.9	1.3	-1.3	3.0
Locomotor activity	1.5	2.4	3.0	1.7	-1.7	1.2
Locomotor testing distance	0.7	1.1	1.4	1.1	-1.2	1.0
Locomotor testing rearing	5.6	8.8	9.0	2.9	-3.0	3.0
Light reinforcement 1	0.6	1.0	1.5	0.8	-1.0	1.2
Light reinforcement 2	1.1	1.4	2.4	1.2	-1.6	0.6
Reaction time number correct	1.7	2.5	2.6	1.6	-1.5	1.6
Reaction time mean minus median	0.6	0.8	1.3	-0.8	1.2	-0.7
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.2	0.6	0.0
Reaction time num false alarms	4.8	6.5	7.9	2.8	-2.6	2.3
Reaction time num false alarms AUC	3.7	5.2	6.5	2.5	-2.3	2.0
Reaction time trials correct on left	1.7	2.5	2.6	1.6	-1.5	1.6
Reaction time trials on left	1.8	2.5	2.7	1.6	-1.6	1.6
Reaction time mean	1.3	1.8	2.1	-1.5	1.2	-1.3
Reaction time mean AUC	1.2	1.6	2.0	-1.3	1.1	-1.4
Median of all reaction times	1.1	1.5	1.8	-1.3	1.0	-1.3
Reaction time omissions	0.3	0.3	0.8	0.5	-0.9	0.1
Reaction time false alarm rate	0.6	0.8	1.2	1.1	-0.9	0.6
Reaction time premature initiation rate	1.8	2.4	3.1	-1.7	1.1	-1.8
Reaction time premature initiations	0.4	0.5	0.9	-0.8	0.3	-1.0
Std. dev. reaction times	0.8	1.0	1.2	-1.0	1.1	-0.9
Reaction time trials completed	1.8	2.5	2.7	1.6	-1.6	1.6
Reaction time trials AUC	2.3	3.3	3.5	1.8	-1.9	1.7
Social response proportion	1.0	1.1	1.5	1.0	-1.2	0.9
Social responses	2.4	3.2	4.7	1.5	-1.6	2.2
Social time	0.6	0.8	1.3	-0.7	1.1	0.8
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.4	0.3
Cocaine response after cond. corrected	0.2	0.3	0.4	0.3	-0.6	-0.6
Cocaine response after cond. not corrected	0.6	0.7	1.2	0.7	-1.1	0.6
Cocaine response before conditioning	3.2	3.9	8.2	1.4	-1.3	2.9
Saline control response	1.0	1.4	2.5	0.9	-0.9	1.6
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	-0.3	0.3	1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.2	-0.2	0.1	1.1
Condit. Reinf. active responses	0.4	0.5	1.2	-0.4	0.5	1.1
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.5	0.7	-0.0
Condit. Reinf. lever presses	0.6	0.8	1.1	0.8	-0.8	1.1
Condit. Reinf. lever reinforcers received	0.5	0.7	1.9	-0.3	0.4	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	0.4	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.2	-0.5
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.7	0.7	-0.1
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.2	0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	-0.0	-0.4
Pavlov. Cond. lever contacts	0.3	0.4	0.5	0.7	-0.6	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.4	-0.4	0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.7	-0.1	0.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	-0.3	0.2
Pavlov. Cond. response bias	0.2	0.2	0.4	0.4	-0.3	0.7
Conditioned reinforcement - actives	1.1	1.1	1.6	1.3	-1.2	0.4
Conditioned reinforcement - inactives	1.5	1.7	2.3	0.9	-1.4	1.5
Conditioned locomotion	0.8	0.9	1.4	1.2	-1.1	0.4
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.4	0.1	0.5
Intermittent access intake escalation	0.0	0.0	0.1	0.3	0.2	0.2
Intermittent access intake escalation 2	0.1	0.1	0.2	0.2	0.3	0.5
Intermitt. access day 1 inactive lever presses	0.9	1.0	2.2	0.7	-1.5	0.5
Intermitt. access day 15 inactive lever presses	2.9	3.2	3.2	1.8	-1.8	1.8
Intermitt. access escalation Index	0.1	0.1	0.2	0.4	-0.1	-0.5
Intermittent access day 1 total infusions	0.9	1.0	1.2	0.9	-1.1	0.9
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.6	-0.5	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	-0.3	0.2
Intermittent access total infusions	0.6	0.6	0.8	0.8	-0.9	0.6
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.6	0.0	-0.6
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.4	0.2	-0.8
Intermittent access total locomotion	0.1	0.1	0.2	-0.0	-0.4	-0.1
Intermittent access standard deviation	1.0	1.1	2.4	1.6	-0.7	0.6
Cocaine induced anxiety	1.4	1.6	3.4	-1.8	1.2	-0.4
Post-drug Anxiety	0.1	0.1	0.3	-0.5	-0.0	-0.1
Baseline Anxiety	0.2	0.3	0.4	0.6	-0.5	-0.3
Lifetime Intake	0.6	0.6	0.9	0.8	-1.0	0.5
Incentive Sensitization - Responses	0.3	0.3	0.4	0.5	-0.6	0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.6	-0.7	0.3
Progressive ratio test 1 active lever presses	0.4	0.4	0.9	0.1	-0.5	1.0
Progressive ratio test 1 breakpoint	0.3	0.3	0.7	0.1	-0.4	0.8
Progressive ratio test 1 inactive lever presses	2.6	2.8	4.3	1.2	-1.6	2.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.8	0.6	-0.9	0.4
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	0.6	-0.9	0.4
Progressive ratio test 2 inactive lever presses	0.9	1.1	1.5	0.9	-0.9	1.2
Total sessions with >9 infusions	2.4	2.7	3.2	1.4	-1.8	1.7
Short access day 1 total inactive lever presses	1.5	1.7	2.3	1.3	-1.5	1.1
Short access day 10 total inactive lever presses	0.4	0.5	0.7	-0.9	0.4	-0.7
Short access day 1 total infusions	0.3	0.4	0.5	0.4	-0.7	0.6
Short access day 10 total infusions	2.2	2.4	3.0	1.7	-1.6	1.2
Short access total infusions	0.3	0.4	0.8	0.6	-0.9	0.2
Short access day 1 locomotion	0.3	0.4	0.7	0.3	-0.8	0.5
Short access day 10 total locomotion	0.8	0.9	1.3	-1.1	0.7	-0.9
Short access total locomotion	0.2	0.2	0.3	-0.4	-0.0	-0.6
Compulsive drug intake	0.1	0.1	0.3	-0.5	0.2	-0.2
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.3	0.1	-0.1
One hour access (shock baseline)	0.9	1.1	1.8	1.3	-0.9	0.7
Number of responses in last shaping day	0.7	0.7	1.1	0.9	-1.1	0.4
Context. condit. distance diff. score	0.1	0.1	0.2	0.3	0.1	0.4
Locomotion velocity, session 1	0.7	0.7	1.0	-1.0	1.0	-0.3
Locomotion distance, session 1	0.3	0.4	0.9	-0.4	0.5	0.9
Locomotion velocity, session 2	1.0	1.1	1.5	0.9	-1.0	1.2
Locomotion distance, session 2	1.2	1.7	3.5	0.9	-0.8	1.9
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	-0.2	0.4
Locomotion distance, session 3	0.4	0.4	0.8	-0.5	0.9	0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.5	-0.6	-0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	-0.3	-0.5
Locomotion velocity, session 7	1.2	1.3	1.6	-1.3	1.3	-0.9
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	0.4	-0.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.3	-0.3	0.6
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.6	-0.6	0.7
Locomotion velocity, session 8	0.1	0.1	0.3	-0.3	0.5	-0.0
Locomotion distance, session 8	0.3	0.4	1.0	0.4	-0.0	1.0
Degree of sensitization distance	0.1	0.1	0.2	0.1	-0.4	-0.4
Degree of sensitization stereotypy	1.0	1.1	1.8	0.9	-0.8	1.3
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	1.0	-1.0	0.4
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.3	1.1	-1.1	0.2
Condit. Reinf. active responses	0.4	0.5	0.7	0.6	-0.8	0.6
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.7	0.4	0.4
Incentive salience index mean	0.7	0.8	0.9	0.9	-0.9	0.8
Condit. Reinf. lever presses	0.3	0.4	0.6	0.5	-0.6	0.8
Time in familiar zone, hab. session 1	0.4	0.4	1.0	-0.3	0.3	1.0
Time in novel zone, hab. session 1	1.1	1.0	1.6	1.3	-1.2	0.2
Total zone transitions, hab. session 1	0.3	0.4	1.1	-0.1	0.2	1.1
Total locomotion distance, hab. session 1	0.4	0.6	1.2	-0.8	1.1	-0.0
Locomotion velocity, hab. session 1	1.0	1.5	2.3	-1.3	1.5	-0.6
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	0.2	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.6	-0.3	0.2
Total zone transitions, hab. session 2	0.8	1.1	2.8	0.4	-0.4	1.7
Total locomotion distance, hab. session 2	0.5	0.6	1.2	-0.8	1.1	-0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.6	0.9	-0.1
Novel to familiar place preference ratio	0.7	0.8	0.8	0.9	-0.8	0.9
Novelty place preference	0.6	0.7	0.9	0.8	-0.7	0.9
Time in novel zone, NPP test	0.7	0.7	1.0	0.8	-0.7	1.0
Total zone transitions, NPP test	0.2	0.3	0.6	0.5	-0.3	0.8
Total locomotion distance, NPP test	0.1	0.1	0.2	0.3	0.1	0.5
Locomotion velocity, NPP test	0.1	0.2	0.4	0.3	0.1	0.6
Pavlov. Cond. lever latency	0.6	0.8	1.1	-0.9	1.0	-0.8
Pavlov. Cond. magazine entry latency	1.0	1.3	1.9	1.3	-1.4	0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	-0.1	-0.3
Pavlov. Cond. index score	1.2	1.6	2.0	1.4	-1.4	0.9
Pavlov. Cond. latency score	0.6	0.8	1.1	1.0	-1.1	0.5
Pavlov. Cond. lever contacts	1.0	1.2	1.5	1.1	-1.2	0.9
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	-1.1	1.0	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.7	0.6	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	2.4	1.5	-1.6	1.0
Pavlov. Cond. response bias	3.0	3.6	4.2	2.0	-2.0	1.6
Bone: apparent density	0.4	0.6	1.1	-0.8	1.1	-0.3
Bone surface	0.4	0.7	2.2	-0.1	0.1	1.5
Bone volume	0.3	0.5	1.1	-0.4	0.6	1.0
Bone: connectivity density	0.1	0.2	0.2	-0.5	0.5	-0.1
Bone: cortical apparent density	0.1	0.2	0.5	-0.1	0.1	-0.7
Bone: cortical area	0.6	1.0	1.8	0.8	-0.6	1.4
Bone: cortical porosity	0.1	0.1	0.2	0.1	0.1	-0.5
Bone: cortical porosity	0.2	0.2	0.4	0.6	-0.4	0.2
Bone: cortical thickness	0.0	0.1	0.2	0.1	0.1	-0.5
Bone: cortical thickness	0.2	0.2	0.4	0.4	-0.2	0.7
Bone: cortical tissue density	0.1	0.2	0.5	-0.1	0.1	-0.7
Bone: elastic displacement	2.8	3.1	4.1	-1.7	1.5	-2.0
Bone: elastic work	0.2	0.2	0.4	-0.6	0.5	-0.2
Bone: endosteal estimation	0.4	0.9	2.7	-0.0	0.0	1.6
Bone: endosteal perimeter	0.2	0.5	1.5	0.0	-0.0	1.2
Bone: final force	1.0	1.6	3.4	0.9	-0.7	1.9
Bone: final moment	1.2	1.9	4.4	0.9	-0.7	2.1
Bone: marrow area	0.5	1.0	2.9	0.0	-0.0	1.7
Bone: maximum diameter	2.5	4.7	6.4	2.0	-1.9	2.5
Bone: maximum force	0.6	1.1	2.6	0.6	-0.5	1.6
Bone: maximum moment	0.7	1.3	3.2	0.6	-0.4	1.8
Bone: minimum diameter	0.9	1.6	4.5	0.4	-0.2	2.1
Bone: periosteal estimation	0.7	1.4	3.7	0.5	-0.4	1.9
Bone: periosteal perimeter	0.6	1.0	2.7	0.3	-0.2	1.6
Bone: post-yield work	0.2	0.2	0.6	-0.1	0.3	0.8
Bone: stiffness	1.9	2.9	5.1	1.5	-1.2	2.3
Bone: tissue strength	0.1	0.1	0.1	-0.2	0.3	-0.3
Bone: trabecular number	0.5	0.7	1.2	-0.9	1.1	-0.4
Bone: trabecular spacing	0.3	0.3	0.6	0.5	-0.8	0.4
Bone: trabecular thickness	0.1	0.2	0.3	0.5	-0.2	0.5
Bone: trabecular tissue density	0.5	0.6	0.8	0.9	-0.9	-0.7
Breakpoint value in progressive ratio session	3.5	3.9	7.6	-1.6	1.2	-2.8
Distance traveled before self-admin	0.3	0.3	0.9	-0.1	-0.1	1.0
Distance traveled after self-admin	0.6	0.7	1.1	-1.1	0.9	-0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	0.4	0.3	0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.1	-0.5	0.4
Diff in mean of infusions in LGA sessions	1.6	1.8	2.1	-1.3	1.5	-1.3
Extinction: sum of active levers before priming	0.8	0.8	1.0	-1.0	1.0	-0.7
Active lever presses in extinction session 6	1.3	1.3	2.0	1.4	-1.2	0.7
Delta distance traveled before/after self-admin	0.7	0.7	1.0	-0.7	1.0	-0.9
Delta ambulatory time before/after self-admin	0.8	0.8	1.0	-0.7	1.0	-1.0
Time in closed arm before self-admin	0.2	0.2	0.4	0.4	-0.6	0.2
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.2	0.1
Time in open arm before self-admin	0.1	0.1	0.2	-0.5	0.3	-0.1
Time in open arm after self-admin	0.0	0.0	0.1	-0.3	-0.2	0.1
Sum of active levers in priming session hrs 5-6	1.9	1.9	2.7	-1.3	1.1	-1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.3	-0.6	0.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	-0.3	0.6	-0.4
Time to tail flick, test, before self-admin	1.9	1.9	2.8	-1.7	1.6	-0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.3	0.6	-0.1
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	1.0	-1.0	0.2
Ambulatory time before self-admin	0.2	0.3	0.7	-0.3	0.0	0.8
Ambulatory time after self-admin	1.1	1.2	2.0	-1.4	1.3	-0.4
Total heroin consumption	0.1	0.2	0.4	-0.0	-0.3	-0.7
Area under the delay curve	0.6	0.6	1.3	-0.6	0.2	-1.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.6	0.6	-0.0
Delay disc. indifference point, 16s delay	0.7	0.7	1.8	-0.5	-0.1	-1.3
Delay disc. indifference point, 2s delay	0.5	0.6	0.8	-0.7	0.6	-0.9
Delay disc. indifference point, 24s delay	0.4	0.4	0.9	0.3	-0.9	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	-0.4	0.4
Delay disc. indifference point, 8s delay	1.0	1.0	1.6	-1.0	0.7	-1.3
Delay discount exponential model param	0.4	0.4	1.0	0.5	-0.1	1.0
Delay discount hyperbolic model param	0.2	0.2	0.6	0.4	-0.1	0.8
Fecal boli incidents, locomotor time 1	0.2	0.3	0.6	-0.4	0.8	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.4	-0.5	0.3	-1.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	-0.4	0.0	-0.8
Bouts of movement, locomotor time 1	1.0	1.2	1.7	-1.2	1.3	-0.5
Total resting periods, locomotor time 1	2.0	2.2	2.7	-1.6	1.6	-1.2
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	0.7	0.2
Distance moved, locomotor task time 1	0.4	0.5	0.8	0.7	-0.9	0.1
Vertical activity count, locomotor time 1	0.1	0.2	0.2	0.2	-0.5	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	0.4	-0.2
Bouts of movement, locomotor time 2	1.5	1.6	2.3	-1.5	1.1	-1.2
Total resting periods, locomotor time 2	2.0	2.1	3.1	-1.7	1.3	-1.3
Rest time, locomotor task time 2	1.4	1.7	2.3	-1.5	1.2	-1.1
Distance moved, locomotor task time 2	1.6	1.8	2.2	1.5	-1.1	1.4
Vertical activity count, locomotor time 2	0.8	0.8	1.0	1.0	-0.7	1.0
Weight adjusted by age	1.0	1.2	2.1	0.9	-0.8	1.4
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	2.9	-1.6	1.7	-0.8
Locomotion in novel chamber	3.2	4.0	5.7	-2.1	1.4	-2.4
Locomotion in novel chamber post-restriction	0.9	1.0	1.2	-0.8	1.1	-1.1
Progressive ratio	0.1	0.1	0.3	-0.3	0.5	-0.1
Food seeking constrained by brief footshock	3.1	3.8	5.3	-2.3	2.3	-0.9
Seeking ratio, punishment vs. effort	0.8	0.9	1.4	-1.2	1.1	-0.5
Run reversals in cocaine runway, females	1.1	1.1	2.0	-1.0	0.5	-1.4
Run reversals in cocaine runway, males	0.8	0.8	1.2	0.9	-0.5	1.1
Latency to leave start box in cocaine runway	0.4	0.5	0.5	-0.6	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.4	0.3	-0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.3	-0.1	0.6
Cd content in liver	0.1	0.1	0.3	-0.3	0.6	0.1
Co content in liver	1.3	1.5	2.4	-1.1	1.6	-1.0
Cu content in liver	0.7	0.8	1.7	0.7	-0.6	1.3
Fe content in liver	0.3	0.3	0.5	0.7	-0.2	0.6
K content in liver	1.8	1.8	2.4	1.3	-1.2	1.6
Mg content in liver	1.5	1.5	2.1	1.3	-1.4	1.0
Mn content in liver	1.1	1.3	1.7	1.3	-1.3	0.8
Na content in liver	0.1	0.1	0.2	0.2	0.1	-0.4
Rb content in liver	0.4	0.5	1.1	0.6	-0.4	1.0
Se content in liver	5.0	6.1	7.9	2.8	-2.8	1.6
Sr content in liver	0.4	0.3	0.8	0.2	-0.4	-0.9
Zn content in liver	1.1	1.2	2.1	1.0	-1.5	0.6