Hub : Genes

ENSRNOG00000067450

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	ENSRNOG00000067450	0.05	0.05	2.2e-03	0.01	0.01	0	0.01	4.0e-02	2.7e-02	1.6e-01	3.1e-02
2	PL	gene expression	ENSRNOG00000067450	0.11	0.1	2.1e-03	0.03	0.02	0.03	0.03	2.6e-03	1.5e-02	2.5e-03	4.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.3	1.0	1.2	1.1	-0.9
BMI without tail	0.0	0.1	0.1	-0.4	-0.2
Body weight	2.8	11.9	12.7	-3.3	3.6
Epididymis fat weight	0.1	0.3	0.6	-0.1	0.8
Glucose	0.0	0.0	0.1	0.3	-0.1
Heart weight	0.1	0.2	0.3	-0.3	0.5
Left kidney weight	3.2	9.2	10.8	-2.8	3.3
Right kidney weight	5.4	15.5	16.1	-3.9	4.0
Tail length	5.1	15.4	17.4	-4.2	3.7
Length with tail	8.7	31.8	32.1	-5.7	5.6
Length without tail	5.9	13.0	15.4	-3.2	3.9
Liver weight, left	0.3	0.4	0.5	0.6	-0.7
Liver weight, right	0.2	0.3	0.6	0.1	-0.8
Parametrial fat weight	0.0	0.1	0.1	-0.2	-0.3
Retroperitoneal fat weight	1.0	3.2	3.6	1.9	-1.7
Intraocular pressure	0.0	0.0	0.0	0.2	-0.0
Extensor digitorum longus weight	0.0	0.1	0.2	0.5	-0.2
Soleus weight	0.1	0.2	0.2	0.5	-0.4
Tibialis anterior weight	0.0	0.1	0.2	-0.1	0.4
Tibia length	2.9	8.2	9.7	-2.6	3.1
Number of licking bursts	3.2	3.8	5.7	2.4	-1.4
Food consumed during 24 hour testing period	0.4	0.5	0.6	-0.7	0.8
Times rat made contact with spout	0.2	0.2	0.5	0.7	0.1
Mean time between licks in bursts	0.1	0.1	0.2	0.0	-0.5
Mean num. licks in bursts	1.7	2.1	2.5	-1.6	1.3
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.4	-0.7
Water consumed over 24 hours	0.5	0.6	0.8	-0.6	0.9
Indifference point 0 sec	0.0	0.0	0.1	-0.3	-0.1
Indifference point AUC	0.4	0.4	0.5	0.6	-0.7
Indifference point function ln k	0.4	0.5	0.7	-0.8	0.6
Indifference point function log k	0.4	0.5	0.7	-0.8	0.6
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	-0.4	0.1
Delay discounting total patch changes 12 sec	0.3	0.4	0.7	-0.2	-0.8
Delay discounting total patch changes 18 sec	0.1	0.1	0.1	0.4	0.2
Delay discounting total patch changes 24 sec	0.9	1.1	1.8	-0.7	1.3
Delay discounting total patch changes 6 sec	0.0	0.0	0.0	-0.1	-0.1
Delay discounting time to switch 0 sec	0.6	1.0	1.6	0.6	-1.3
Delay discounting water rate 0 sec	0.7	1.1	1.4	1.2	-0.9
Delay discounting water rate 12 sec	0.9	1.4	2.5	-0.6	1.6
Delay discounting water rate 18 sec	0.1	0.2	0.2	0.4	-0.4
Delay discounting water rate 24 sec	0.1	0.2	0.2	0.5	0.4
Delay discounting water rate 6 sec	1.1	1.5	2.6	-0.7	1.6
Locomotor activity	0.4	0.7	1.2	0.3	-1.1
Locomotor testing distance	0.2	0.3	0.4	0.5	-0.7
Locomotor testing rearing	1.2	1.9	2.9	1.7	-1.0
Light reinforcement 1	0.1	0.2	0.3	0.6	-0.3
Light reinforcement 2	3.1	4.1	4.6	1.9	-2.1
Reaction time number correct	0.0	0.1	0.1	0.2	0.3
Reaction time mean minus median	0.6	0.7	1.0	-0.7	1.0
Reaction time mean minus median AUC	1.4	1.8	2.7	-0.9	1.6
Reaction time num false alarms	0.8	1.1	1.7	1.3	-0.7
Reaction time num false alarms AUC	1.0	1.5	1.9	1.4	-1.0
Reaction time trials correct on left	0.0	0.1	0.1	0.2	0.3
Reaction time trials on left	0.1	0.1	0.1	0.2	0.3
Reaction time mean	0.4	0.6	1.2	-0.1	1.1
Reaction time mean AUC	0.3	0.4	0.7	-0.0	0.8
Median of all reaction times	0.2	0.3	0.5	0.1	0.7
Reaction time omissions	0.0	0.0	0.0	0.1	0.1
Reaction time false alarm rate	0.7	0.9	1.1	1.0	-0.9
Reaction time premature initiation rate	0.0	0.1	0.1	-0.0	-0.4
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.2
Std. dev. reaction times	1.0	1.4	2.5	-0.6	1.6
Reaction time trials completed	0.1	0.1	0.1	0.2	0.3
Reaction time trials AUC	0.0	0.1	0.1	0.3	0.2
Social response proportion	1.5	1.6	2.7	-1.6	0.7
Social responses	0.4	0.5	1.0	-1.0	-0.2
Social time	2.4	3.1	3.5	-1.6	1.9
Conditioned locomotion	0.8	1.0	1.4	0.8	-1.2
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.2	-0.5
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	-0.3
Cocaine response before conditioning	1.5	1.9	2.2	-1.2	1.5
Saline control response	0.0	0.0	0.1	-0.3	-0.0
Condit. Reinf. active minus inactive responses	1.3	1.6	2.6	-1.6	0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	-0.1
Condit. Reinf. active responses	3.0	4.2	5.3	-2.3	1.8
Condit. Reinf. inactive responses	3.2	3.9	4.4	-2.1	1.9
Condit. Reinf. lever presses	7.0	9.6	12.0	-3.5	2.7
Condit. Reinf. lever reinforcers received	3.2	4.5	5.2	-2.3	1.9
Pavlov. Cond. lever latency	4.5	6.2	6.5	2.5	-2.4
Pavlov. Cond. magazine entry latency	2.2	2.5	3.5	-1.9	1.2
Pavlov. Cond. change in total contacts	7.4	10.3	10.4	-3.2	3.2
Pavlov. Cond. index score	4.6	6.0	6.4	-2.5	2.4
Pavlov. Cond. latency score	4.1	5.2	5.8	-2.4	2.2
Pavlov. Cond. lever contacts	4.2	5.9	6.3	-2.4	2.5
Pavlov. Cond. magazine entry number	3.9	4.8	5.2	2.1	-2.3
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.6	1.3	-0.8
Pavlov. Cond. lever-magazine prob. diff.	4.6	6.0	6.4	-2.5	2.4
Pavlov. Cond. response bias	4.9	6.7	7.5	-2.4	2.7
Conditioned reinforcement - actives	0.1	0.1	0.1	0.3	-0.2
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.3	0.4
Conditioned locomotion	2.6	3.1	3.5	1.9	-1.6
Intermittent access intake day 1-15 change	3.1	3.0	4.2	-1.4	2.1
Intermittent access intake escalation	2.9	2.9	4.1	-1.3	2.0
Intermittent access intake escalation 2	1.9	1.9	2.0	-1.4	1.4
Intermitt. access day 1 inactive lever presses	2.2	2.3	3.5	-1.9	1.1
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.4	0.1
Intermitt. access escalation Index	0.1	0.1	0.2	0.5	-0.0
Intermittent access day 1 total infusions	2.4	2.7	3.8	2.0	-1.3
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.5	0.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.7	-0.3
Intermittent access total infusions	0.6	0.7	1.1	1.1	-0.5
Intermittent access day 1 locomotion	1.6	1.6	2.1	1.4	-1.1
Intermittent access day 15 total locomotion	0.2	0.2	0.4	0.6	0.3
Intermittent access total locomotion	1.5	1.7	2.2	1.5	-1.1
Intermittent access standard deviation	4.7	5.0	5.3	-2.2	2.3
Cocaine induced anxiety	0.4	0.4	0.7	-0.8	0.4
Post-drug Anxiety	0.4	0.4	0.8	-0.1	-0.9
Baseline Anxiety	1.6	1.7	1.8	1.3	-1.3
Lifetime Intake	0.7	0.8	1.3	1.1	-0.5
Incentive Sensitization - Responses	0.0	0.0	0.1	0.3	0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.3	0.1
Progressive ratio test 1 active lever presses	0.3	0.4	0.7	-0.2	0.8
Progressive ratio test 1 breakpoint	0.6	0.6	0.9	-0.6	1.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.2	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.5	0.0
Total sessions with >9 infusions	1.0	1.1	1.6	1.3	-0.8
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	-0.1
Short access day 10 total inactive lever presses	0.9	1.0	1.6	-1.3	0.6
Short access day 1 total infusions	0.1	0.1	0.2	0.4	-0.1
Short access day 10 total infusions	0.4	0.5	0.8	0.9	-0.4
Short access total infusions	0.8	0.9	1.3	1.2	-0.6
Short access day 1 locomotion	0.5	0.5	1.0	1.0	-0.2
Short access day 10 total locomotion	0.2	0.2	0.2	-0.5	0.4
Short access total locomotion	1.2	1.2	1.3	1.1	-1.1
Compulsive drug intake	0.1	0.1	0.1	-0.4	0.2
One hour access (0.3 mA shock)	0.6	0.7	1.0	-0.7	1.0
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.1
Number of responses in last shaping day	0.1	0.1	0.1	0.2	-0.3
Context. condit. distance diff. score	0.1	0.1	0.1	0.3	0.1
Locomotion velocity, session 1	0.3	0.3	0.3	0.6	-0.5
Locomotion distance, session 1	0.5	0.7	1.0	-0.6	1.0
Locomotion velocity, session 2	0.7	0.9	1.4	0.6	-1.2
Locomotion distance, session 2	1.4	2.0	2.6	1.6	-1.2
Locomotion velocity, session 3	0.2	0.2	0.4	0.6	-0.3
Locomotion distance, session 3	1.8	1.9	1.9	-1.4	1.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	0.5	-1.1
Stereotopy head waving duration, day 3	1.3	1.6	2.4	0.9	-1.5
Locomotion velocity, session 7	0.2	0.3	0.4	-0.3	0.7
Locomotion distance, session 7	0.3	0.3	0.6	-0.3	0.8
Stereotopy head waving bouts, day 7	1.1	1.3	1.4	1.2	-1.1
Stereotopy head waving duration, day 7	2.5	3.0	3.1	1.7	-1.8
Locomotion velocity, session 8	4.2	5.0	5.9	2.4	-2.0
Locomotion distance, session 8	0.8	1.2	2.0	1.4	-0.6
Degree of sensitization distance	0.1	0.1	0.2	0.5	-0.2
Degree of sensitization stereotypy	1.5	1.6	2.0	1.4	-1.1
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.5	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	0.2	-1.0
Condit. Reinf. active responses	2.5	3.1	3.1	1.8	-1.7
Condit. Reinf. inactive responses	2.5	2.9	3.7	1.9	-1.4
Incentive salience index mean	0.4	0.5	0.7	0.5	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.3	0.1	-0.5
Time in familiar zone, hab. session 1	0.8	0.8	0.8	-0.8	0.9
Time in novel zone, hab. session 1	2.1	2.1	2.4	1.3	-1.5
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.2	-0.0
Total locomotion distance, hab. session 1	0.7	1.1	1.9	-1.4	0.5
Locomotion velocity, hab. session 1	0.5	0.7	1.3	-1.1	0.3
Time in familiar zone, hab. session 2	1.7	1.8	3.2	-1.8	0.6
Time in novel zone, hab. session 2	1.0	1.0	1.7	1.3	-0.6
Total zone transitions, hab. session 2	3.3	4.3	4.4	2.1	-2.1
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.4	-0.8
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.5	-0.8
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.2	0.3
Novelty place preference	0.1	0.1	0.1	-0.1	0.3
Time in novel zone, NPP test	0.0	0.0	0.0	0.1	0.2
Total zone transitions, NPP test	0.0	0.0	0.1	0.3	-0.1
Total locomotion distance, NPP test	2.3	3.2	3.8	-2.0	1.6
Locomotion velocity, NPP test	2.3	3.3	4.3	-2.1	1.5
Pavlov. Cond. lever latency	0.4	0.5	0.7	-0.5	0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.6	-0.8
Pavlov. Cond. change in total contacts	0.6	0.6	0.7	0.7	-0.8
Pavlov. Cond. index score	0.8	1.0	1.4	0.8	-1.2
Pavlov. Cond. latency score	0.5	0.6	0.9	0.6	-1.0
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.1	-0.6
Pavlov. Cond. magazine entry number	0.6	0.8	0.9	-0.8	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.8	0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.7	0.9	-1.3
Pavlov. Cond. response bias	0.3	0.3	0.6	0.2	-0.8
Bone: apparent density	0.8	1.4	1.8	-1.0	1.3
Bone surface	1.7	3.0	3.8	-1.5	2.0
Bone volume	1.9	3.2	4.4	-1.5	2.1
Bone: connectivity density	0.2	0.4	0.5	-0.5	0.7
Bone: cortical apparent density	1.8	2.3	3.3	1.8	-1.2
Bone: cortical area	1.3	2.0	2.3	-1.5	1.3
Bone: cortical porosity	2.4	2.5	2.7	1.6	-1.6
Bone: cortical porosity	2.9	3.1	3.5	1.9	-1.6
Bone: cortical thickness	0.3	0.5	0.8	-0.9	0.5
Bone: cortical thickness	0.6	0.7	0.7	0.8	-0.8
Bone: cortical tissue density	2.1	2.8	3.8	2.0	-1.3
Bone: elastic displacement	0.0	0.0	0.0	-0.2	-0.1
Bone: elastic work	1.7	2.2	2.7	-1.6	1.3
Bone: endosteal estimation	1.5	3.3	3.5	-1.9	1.7
Bone: endosteal perimeter	1.3	2.7	2.9	-1.7	1.5
Bone: final force	1.4	2.2	2.4	-1.5	1.4
Bone: final moment	1.9	3.1	3.3	-1.8	1.7
Bone: marrow area	1.6	3.4	3.8	-1.9	1.7
Bone: maximum diameter	1.3	2.3	2.6	-1.6	1.4
Bone: maximum force	2.4	4.1	4.1	-2.0	2.0
Bone: maximum moment	2.9	5.0	5.1	-2.3	2.2
Bone: minimum diameter	2.7	4.9	5.4	-2.3	2.1
Bone: periosteal estimation	2.0	4.1	4.5	-2.1	1.9
Bone: periosteal perimeter	1.3	2.1	3.1	-1.7	1.1
Bone: post-yield work	1.2	1.7	1.9	-1.2	1.4
Bone: stiffness	1.2	1.9	1.9	-1.4	1.4
Bone: tissue strength	2.7	2.6	2.9	-1.5	1.7
Bone: trabecular number	1.5	2.4	3.1	-1.3	1.8
Bone: trabecular spacing	0.3	0.3	0.7	-0.8	-0.1
Bone: trabecular thickness	0.2	0.3	0.3	0.4	0.6
Bone: trabecular tissue density	1.2	1.7	1.8	1.3	-1.3
Breakpoint value in progressive ratio session	0.9	1.0	1.9	-1.4	0.2
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.1
Distance traveled after self-admin	3.7	4.1	4.6	-2.2	1.9
Delta time in closed arm before/after self-admin	2.8	2.7	2.9	-1.6	1.7
Delta time in open arm before/after self-admin	0.6	0.6	0.7	0.9	-0.6
Diff in mean of infusions in LGA sessions	0.9	1.0	1.8	0.4	-1.3
Extinction: sum of active levers before priming	3.4	3.4	3.8	-2.0	1.7
Active lever presses in extinction session 6	3.1	3.0	4.8	-2.2	1.1
Delta distance traveled before/after self-admin	4.4	4.7	5.3	-2.0	2.3
Delta ambulatory time before/after self-admin	5.0	5.4	6.7	-2.0	2.6
Time in closed arm before self-admin	2.4	2.8	3.2	1.8	-1.5
Time in closed arm after self-admin	0.1	0.1	0.1	-0.3	-0.3
Time in open arm before self-admin	4.3	4.6	5.6	-2.4	1.9
Time in open arm after self-admin	1.3	1.4	1.9	-0.9	1.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.4	0.3
Time to tail flick, vehicle, before self-admin	1.0	1.1	1.1	1.0	-1.0
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.6	-0.4	-0.8
Time to tail flick, test, before self-admin	0.7	0.7	1.2	1.1	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	-0.9	0.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.1	-0.7
Ambulatory time before self-admin	0.1	0.1	0.2	-0.2	-0.4
Ambulatory time after self-admin	6.4	7.1	7.4	-2.7	2.6
Total heroin consumption	0.1	0.2	0.4	-0.6	0.0
Area under the delay curve	0.1	0.1	0.2	-0.5	-0.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.0	0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	-0.9	-0.3
Delay disc. indifference point, 2s delay	0.7	0.7	0.9	-0.8	0.9
Delay disc. indifference point, 24s delay	1.5	1.5	1.8	-1.3	1.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.2	-0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	0.2
Delay discount exponential model param	0.2	0.2	0.3	0.6	0.0
Delay discount hyperbolic model param	0.1	0.1	0.2	0.5	0.0
Fecal boli incidents, locomotor time 1	3.1	3.3	5.4	1.1	-2.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.5	0.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	-0.3
Bouts of movement, locomotor time 1	0.3	0.3	0.5	-0.7	0.4
Total resting periods, locomotor time 1	0.2	0.3	0.5	-0.7	0.2
Rest time, locomotor task time 1	1.8	2.0	3.5	0.7	-1.9
Distance moved, locomotor task time 1	0.4	0.5	0.9	0.1	1.0
Vertical activity count, locomotor time 1	2.1	2.2	3.2	-1.1	1.8
Time >=10cm from walls, locomotor time 2	2.2	2.3	3.2	1.2	-1.8
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	-0.2
Rest time, locomotor task time 2	0.8	0.9	1.6	0.4	-1.3
Distance moved, locomotor task time 2	0.3	0.3	0.4	0.6	0.5
Vertical activity count, locomotor time 2	1.0	1.1	1.8	-0.6	1.3
Weight adjusted by age	0.2	0.2	0.3	0.1	0.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	1.9	-0.8	1.4
Locomotion in novel chamber	0.7	0.8	1.6	0.1	-1.3
Locomotion in novel chamber post-restriction	0.2	0.3	0.3	-0.5	-0.5
Progressive ratio	0.1	0.2	0.3	-0.1	-0.6
Food seeking constrained by brief footshock	2.6	3.2	4.4	-2.1	1.4
Seeking ratio, punishment vs. effort	0.7	0.8	1.0	-0.8	1.0
Run reversals in cocaine runway, females	0.9	0.9	1.7	-0.3	1.3
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.1	-0.3
Latency to leave start box in cocaine runway	0.5	0.5	1.0	0.1	1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	0.5	0.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	-0.1	0.7
Cd content in liver	0.2	0.2	0.4	-0.2	0.6
Co content in liver	0.5	0.6	0.7	0.7	-0.8
Cu content in liver	0.5	0.6	0.8	-0.6	0.9
Fe content in liver	0.0	0.1	0.1	0.2	-0.3
K content in liver	0.1	0.1	0.1	-0.1	-0.4
Mg content in liver	1.0	1.1	1.8	0.6	-1.3
Mn content in liver	1.2	1.4	2.2	0.7	-1.5
Na content in liver	1.4	1.4	1.5	-1.2	1.2
Rb content in liver	0.2	0.3	0.4	0.4	-0.6
Se content in liver	7.8	9.4	9.9	3.0	-3.1
Sr content in liver	0.9	0.8	1.1	0.7	-1.0
Zn content in liver	0.2	0.2	0.2	0.4	-0.5