Hub : Genes

ENSRNOG00000067235

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000067235 0.2 0.11 0.0e+00 0.12 0.14 0.14 0.14 2.7e-13 3.3e-15 2.5e-15 2.7e-15
2 Adipose intron excision ratio chr2:110849487:110862003 0.11 0.06 1.1e-11 0.09 0.09 0.07 0.09 2.4e-10 1.0e-09 4.8e-08 7.3e-10
3 Adipose intron excision ratio chr2:110849831:110862003 0.11 0.06 9.1e-11 0.08 0.08 0.07 0.08 3.4e-09 5.4e-09 1.7e-08 5.2e-09
4 Adipose mRNA stability ENSRNOG00000067235 0.03 0.03 9.7e-03 0.01 0 0.01 0.01 7.9e-03 1.9e-01 4.3e-02 6.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.31.02.11.5-0.90.90.6
BMI without tail0.10.30.80.30.4-0.40.9
Body weight1.35.68.22.0-2.92.9-1.4
Epididymis fat weight0.61.42.20.3-1.31.3-1.5
Glucose0.50.82.0-0.90.5-0.5-1.4
Heart weight2.13.05.92.2-0.80.82.4
Left kidney weight0.61.62.41.2-1.61.6-0.6
Right kidney weight1.23.55.52.3-2.02.00.4
Tail length0.00.10.2-0.40.4-0.4-0.1
Length with tail0.51.92.60.5-1.61.6-1.5
Length without tail1.63.65.21.2-2.32.3-1.6
Liver weight, left1.72.83.60.8-1.81.8-1.9
Liver weight, right0.81.31.70.5-1.31.3-1.3
Parametrial fat weight1.12.12.8-1.71.6-1.6-0.8
Retroperitoneal fat weight0.92.93.81.2-2.02.0-1.6
Intraocular pressure0.00.10.1-0.3-0.10.1-0.3
Extensor digitorum longus weight0.20.61.4-0.10.8-0.81.2
Soleus weight3.08.727.71.71.4-1.45.3
Tibialis anterior weight0.10.20.40.6-0.00.00.6
Tibia length1.64.68.70.5-2.22.2-3.0
Number of licking bursts0.30.41.0-0.70.3-0.3-1.0
Food consumed during 24 hour testing period0.20.20.40.1-0.50.5-0.7
Times rat made contact with spout0.70.81.5-0.2-0.90.9-1.2
Mean time between licks in bursts2.94.07.5-2.71.9-1.9-1.2
Mean num. licks in bursts0.20.30.30.5-0.60.60.6
Std. dev. time between licks in bursts0.30.30.7-0.60.2-0.2-0.8
Water consumed over 24 hours0.70.81.20.9-1.11.1-0.2
Indifference point 0 sec0.50.81.71.3-0.30.31.2
Indifference point AUC8.19.513.43.7-3.53.50.6
Indifference point function ln k5.37.412.0-3.52.9-2.9-1.1
Indifference point function log k5.37.412.0-3.52.9-2.9-1.1
Delay discounting total patch changes 0 sec0.61.02.11.3-0.20.21.4
Delay discounting total patch changes 12 sec5.67.412.83.6-2.72.71.5
Delay discounting total patch changes 18 sec2.83.77.32.7-1.81.81.1
Delay discounting total patch changes 24 sec8.310.418.54.3-3.13.11.9
Delay discounting total patch changes 6 sec4.16.211.33.4-2.12.12.2
Delay discounting time to switch 0 sec3.65.58.7-2.92.4-2.4-1.2
Delay discounting water rate 0 sec1.52.34.42.1-1.01.01.7
Delay discounting water rate 12 sec0.10.10.1-0.10.4-0.40.1
Delay discounting water rate 18 sec0.20.30.40.3-0.60.6-0.6
Delay discounting water rate 24 sec1.21.63.51.5-0.50.51.9
Delay discounting water rate 6 sec0.30.40.5-0.30.7-0.70.7
Locomotor activity3.45.37.91.9-2.82.8-1.4
Locomotor testing distance2.74.56.62.2-2.62.6-0.2
Locomotor testing rearing3.45.47.32.6-2.72.70.3
Light reinforcement 10.91.62.31.4-1.51.5-0.3
Light reinforcement 20.70.91.21.1-1.11.10.3
Reaction time number correct0.30.51.20.0-0.60.6-1.1
Reaction time mean minus median3.34.35.9-2.42.3-2.3-0.8
Reaction time mean minus median AUC1.51.92.7-1.51.6-1.6-0.2
Reaction time num false alarms1.52.03.51.9-1.51.50.6
Reaction time num false alarms AUC1.11.52.51.6-1.31.30.4
Reaction time trials correct on left0.30.51.20.0-0.60.6-1.1
Reaction time trials on left0.30.51.3-0.1-0.50.5-1.2
Reaction time mean3.75.18.2-2.92.1-2.1-1.9
Reaction time mean AUC3.64.87.6-2.82.1-2.1-1.6
Median of all reaction times3.04.16.7-2.61.8-1.8-1.7
Reaction time omissions2.73.65.1-2.22.1-2.1-0.6
Reaction time false alarm rate0.91.32.31.5-0.80.81.1
Reaction time premature initiation rate0.30.30.50.5-0.70.70.3
Reaction time premature initiations0.40.61.00.4-1.01.0-0.4
Std. dev. reaction times3.54.86.6-2.62.4-2.4-0.9
Reaction time trials completed0.30.51.3-0.1-0.50.5-1.2
Reaction time trials AUC0.30.41.3-0.2-0.40.4-1.1
Social response proportion1.51.72.2-1.51.4-1.4-0.8
Social responses0.20.30.70.30.4-0.40.8
Social time1.21.64.7-1.3-0.00.0-2.2
Conditioned locomotion1.61.92.9-1.01.7-1.70.8
Cocaine response after cond. corrected1.21.32.0-1.41.3-1.3-0.3
Cocaine response after cond. not corrected0.70.81.5-1.20.7-0.7-0.9
Cocaine response before conditioning1.11.42.01.2-1.41.4-0.2
Saline control response0.10.10.10.3-0.30.3-0.4
Condit. Reinf. active minus inactive responses0.50.60.80.3-0.90.9-0.9
Condit. Reinf. active-inactive response ratio0.10.10.3-0.2-0.20.2-0.6
Condit. Reinf. active responses2.23.15.10.6-1.91.9-2.3
Condit. Reinf. inactive responses3.13.85.40.9-2.12.1-2.3
Condit. Reinf. lever presses0.60.91.21.0-1.11.10.1
Condit. Reinf. lever reinforcers received1.82.63.70.7-1.81.8-1.9
Pavlov. Cond. lever latency0.91.21.7-1.31.2-1.2-0.5
Pavlov. Cond. magazine entry latency0.20.20.30.1-0.50.5-0.4
Pavlov. Cond. change in total contacts1.21.72.50.8-1.61.6-1.1
Pavlov. Cond. index score0.40.50.80.7-0.90.9-0.2
Pavlov. Cond. latency score0.20.30.50.4-0.70.7-0.3
Pavlov. Cond. lever contacts0.71.01.61.3-0.90.90.9
Pavlov. Cond. magazine entry number0.30.30.5-0.40.7-0.70.2
Pavlov. Cond. intertrial magazine entries0.40.50.60.7-0.80.8-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.6-1.01.0-0.4
Pavlov. Cond. response bias0.40.50.70.9-0.80.80.3
Conditioned reinforcement - actives1.51.53.1-1.80.9-0.9-1.1
Conditioned reinforcement - inactives0.40.51.2-1.10.6-0.6-0.3
Conditioned locomotion0.10.10.2-0.40.2-0.20.1
Intermittent access intake day 1-15 change0.10.10.1-0.20.2-0.2-0.4
Intermittent access intake escalation0.30.30.4-0.60.6-0.6-0.5
Intermittent access intake escalation 20.10.10.4-0.2-0.10.1-0.7
Intermitt. access day 1 inactive lever presses0.10.10.3-0.50.4-0.40.1
Intermitt. access day 15 inactive lever presses1.41.53.1-0.1-1.21.2-1.8
Intermitt. access escalation Index2.52.23.01.7-1.71.7-0.1
Intermittent access day 1 total infusions1.41.63.2-1.80.2-0.2-1.8
Intermittent access day 15 total infusions0.80.92.2-1.20.3-0.3-1.5
Intermittent access terminal intake (last 3 days)2.12.36.1-1.80.2-0.2-2.5
Intermittent access total infusions1.31.43.8-1.3-0.20.2-2.0
Intermittent access day 1 locomotion0.30.30.7-0.80.1-0.1-0.7
Intermittent access day 15 total locomotion1.21.31.8-1.11.3-1.30.6
Intermittent access total locomotion1.21.42.5-1.61.2-1.2-0.6
Intermittent access standard deviation0.70.70.9-1.01.0-1.0-0.3
Cocaine induced anxiety0.10.10.20.4-0.30.3-0.1
Post-drug Anxiety1.11.21.5-1.21.1-1.1-0.7
Baseline Anxiety1.01.01.4-1.21.2-1.2-0.2
Lifetime Intake1.51.74.3-1.5-0.30.3-2.1
Incentive Sensitization - Responses1.21.23.9-0.9-0.10.1-2.0
Incentive Sensitization - Breakpoint1.31.44.3-1.0-0.10.1-2.1
Progressive ratio test 1 active lever presses0.50.50.70.0-0.90.9-0.7
Progressive ratio test 1 breakpoint0.40.40.9-0.4-0.60.6-0.9
Progressive ratio test 1 inactive lever presses0.70.71.10.2-1.11.1-0.8
Progressive ratio test 2 active lever presses1.41.44.0-0.5-0.90.9-2.0
Progressive ratio test 2 breakpoint1.31.53.8-0.2-1.01.0-2.0
Progressive ratio test 2 inactive lever presses0.70.82.2-0.9-0.30.3-1.5
Total sessions with >9 infusions1.01.12.5-1.61.0-1.0-0.2
Short access day 1 total inactive lever presses0.10.10.4-0.1-0.20.2-0.6
Short access day 10 total inactive lever presses0.40.51.40.70.2-0.21.2
Short access day 1 total infusions0.70.71.7-1.0-0.30.3-1.3
Short access day 10 total infusions0.60.61.4-0.9-0.40.4-1.2
Short access total infusions1.21.33.2-1.3-0.40.4-1.8
Short access day 1 locomotion1.11.21.61.0-1.31.30.7
Short access day 10 total locomotion1.21.31.7-0.91.3-1.31.0
Short access total locomotion0.10.10.1-0.2-0.40.40.1
Compulsive drug intake0.00.00.00.10.2-0.20.1
One hour access (0.3 mA shock)1.01.13.2-0.9-0.50.5-1.8
One hour access (shock baseline)0.91.13.0-1.1-0.40.4-1.7
Number of responses in last shaping day0.70.71.00.6-1.01.0-0.7
Context. condit. distance diff. score1.72.05.31.6-0.40.42.3
Locomotion velocity, session 13.13.35.01.4-2.22.2-1.2
Locomotion distance, session 12.12.74.11.4-2.02.0-0.8
Locomotion velocity, session 21.11.32.60.2-1.11.1-1.6
Locomotion distance, session 21.21.72.30.8-1.51.5-1.2
Locomotion velocity, session 30.00.10.10.0-0.20.2-0.4
Locomotion distance, session 30.40.40.60.4-0.80.8-0.5
Stereotopy head waving bouts, day 30.10.20.20.4-0.50.5-0.1
Stereotopy head waving duration, day 30.20.30.90.20.2-0.21.0
Locomotion velocity, session 70.10.10.10.1-0.30.3-0.3
Locomotion distance, session 70.91.11.7-1.31.2-1.2-0.1
Stereotopy head waving bouts, day 70.80.91.51.2-1.01.00.3
Stereotopy head waving duration, day 71.01.22.31.5-0.90.90.8
Locomotion velocity, session 80.80.91.71.3-0.90.90.5
Locomotion distance, session 80.71.11.81.4-1.01.00.7
Degree of sensitization distance1.91.92.9-1.71.5-1.5-0.3
Degree of sensitization stereotypy0.70.81.61.3-0.60.60.9
Condit. Reinf. active minus inactive responses1.41.52.9-1.50.7-0.7-1.7
Condit. Reinf. active-inactive response ratio1.61.72.9-1.71.1-1.1-1.3
Condit. Reinf. active responses1.11.42.4-1.50.7-0.7-1.5
Condit. Reinf. inactive responses0.00.00.1-0.3-0.00.0-0.3
Incentive salience index mean1.82.13.6-1.91.0-1.0-1.8
Condit. Reinf. lever presses0.81.11.9-1.40.8-0.8-1.0
Time in familiar zone, hab. session 10.10.10.1-0.20.4-0.40.2
Time in novel zone, hab. session 11.01.02.91.00.0-0.01.7
Total zone transitions, hab. session 10.30.41.40.50.2-0.21.2
Total locomotion distance, hab. session 10.60.92.50.50.6-0.61.6
Locomotion velocity, hab. session 10.30.51.40.20.5-0.51.2
Time in familiar zone, hab. session 20.30.30.8-0.5-0.10.1-0.9
Time in novel zone, hab. session 22.82.95.02.2-1.01.02.1
Total zone transitions, hab. session 22.53.24.71.8-2.22.2-0.3
Total locomotion distance, hab. session 21.21.62.31.5-1.41.40.2
Locomotion velocity, hab. session 20.71.01.31.2-1.11.10.1
Novel to familiar place preference ratio3.53.710.72.0-0.00.03.3
Novelty place preference4.34.512.72.3-0.20.23.6
Time in novel zone, NPP test5.25.514.32.7-0.50.53.8
Total zone transitions, NPP test1.42.02.81.1-1.71.7-1.2
Total locomotion distance, NPP test0.60.81.00.8-1.01.0-0.7
Locomotion velocity, NPP test0.50.71.00.5-0.90.9-1.0
Pavlov. Cond. lever latency1.41.72.91.7-0.70.71.7
Pavlov. Cond. magazine entry latency1.21.52.5-1.61.3-1.3-0.5
Pavlov. Cond. change in total contacts2.02.13.5-1.91.4-1.4-1.1
Pavlov. Cond. index score1.31.72.8-1.70.9-0.9-1.6
Pavlov. Cond. latency score1.41.83.0-1.70.8-0.8-1.7
Pavlov. Cond. lever contacts1.82.13.6-1.91.0-1.0-1.7
Pavlov. Cond. magazine entry number1.51.93.01.7-1.41.40.8
Pavlov. Cond. intertrial magazine entries1.31.62.10.8-1.51.5-1.2
Pavlov. Cond. lever-magazine prob. diff.1.41.83.0-1.71.1-1.1-1.4
Pavlov. Cond. response bias1.11.32.0-1.41.1-1.1-0.8
Bone: apparent density0.60.92.90.40.6-0.61.7
Bone surface0.30.60.80.8-0.90.9-0.1
Bone volume0.00.00.0-0.00.1-0.10.1
Bone: connectivity density0.60.92.01.2-0.40.41.4
Bone: cortical apparent density0.30.40.5-0.30.7-0.70.7
Bone: cortical area0.30.50.80.9-0.70.70.6
Bone: cortical porosity0.10.10.1-0.30.3-0.30.3
Bone: cortical porosity0.20.20.3-0.30.5-0.50.5
Bone: cortical thickness0.40.72.30.70.2-0.21.5
Bone: cortical thickness0.40.40.91.0-0.60.60.3
Bone: cortical tissue density0.40.50.6-0.30.8-0.80.8
Bone: elastic displacement0.10.10.50.30.2-0.20.7
Bone: elastic work0.20.30.40.6-0.60.6-0.1
Bone: endosteal estimation0.92.06.1-0.5-1.01.0-2.5
Bone: endosteal perimeter0.71.43.5-0.4-1.01.0-1.9
Bone: final force0.50.81.20.7-1.11.1-0.5
Bone: final moment0.50.91.30.9-1.11.1-0.2
Bone: marrow area0.81.85.4-0.4-0.90.9-2.3
Bone: maximum diameter0.61.11.61.1-1.31.30.0
Bone: maximum force0.50.91.30.6-1.11.1-0.9
Bone: maximum moment0.71.21.70.9-1.31.3-0.7
Bone: minimum diameter0.40.72.0-0.8-0.20.2-1.4
Bone: periosteal estimation0.30.61.4-0.0-0.70.7-1.2
Bone: periosteal perimeter0.50.81.30.6-1.11.1-0.3
Bone: post-yield work0.81.13.5-0.4-0.60.6-1.9
Bone: stiffness0.50.71.00.4-0.90.9-1.0
Bone: tissue strength0.10.10.10.1-0.30.3-0.2
Bone: trabecular number1.11.75.41.00.4-0.42.3
Bone: trabecular spacing2.33.06.00.3-1.71.7-2.5
Bone: trabecular thickness2.42.94.3-1.52.1-2.10.9
Bone: trabecular tissue density1.21.72.9-1.71.2-1.2-1.0
Breakpoint value in progressive ratio session0.30.40.4-0.40.6-0.60.7
Distance traveled before self-admin3.13.34.52.0-2.12.10.1
Distance traveled after self-admin1.11.21.71.3-1.21.2-0.0
Delta time in closed arm before/after self-admin1.81.84.91.4-0.10.12.2
Delta time in open arm before/after self-admin1.91.85.3-0.9-0.70.7-2.3
Diff in mean of infusions in LGA sessions0.30.41.10.10.4-0.41.0
Extinction: sum of active levers before priming0.20.20.30.5-0.50.50.4
Active lever presses in extinction session 60.20.20.3-0.40.5-0.50.2
Delta distance traveled before/after self-admin0.20.20.4-0.50.4-0.4-0.6
Delta ambulatory time before/after self-admin1.51.62.6-1.11.6-1.60.2
Time in closed arm before self-admin1.51.82.8-1.71.4-1.4-0.7
Time in closed arm after self-admin0.60.62.20.30.4-0.41.5
Time in open arm before self-admin0.80.82.50.70.3-0.31.6
Time in open arm after self-admin0.60.71.00.6-1.01.0-0.6
Sum of active levers in priming session hrs 5-60.10.10.3-0.50.2-0.2-0.2
Time to tail flick, vehicle, before self-admin0.90.92.7-0.90.2-0.2-1.6
Time to tail flick, vehicle, after self-admin0.80.92.0-0.1-0.90.9-1.4
Time to tail flick, test, before self-admin1.91.93.40.01.5-1.51.8
Time to tail flick, test, after self-admin2.52.55.70.31.5-1.52.4
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.3-0.20.2-0.5
Delta time to tail flick, test, before/after SA0.60.50.91.0-0.40.40.9
Ambulatory time before self-admin4.54.77.12.1-2.72.7-0.6
Ambulatory time after self-admin0.20.30.40.5-0.60.6-0.2
Total heroin consumption0.20.31.00.20.2-0.21.0
Area under the delay curve1.61.72.3-0.41.5-1.51.4
Delay disc. indifference point, 0s delay0.91.01.51.0-1.21.2-0.2
Delay disc. indifference point, 16s delay3.73.75.2-0.62.3-2.32.0
Delay disc. indifference point, 2s delay0.91.01.4-0.61.2-1.20.8
Delay disc. indifference point, 24s delay1.01.02.60.50.8-0.81.6
Delay disc. indifference point, 4s delay1.11.21.9-0.21.2-1.21.4
Delay disc. indifference point, 8s delay0.20.20.3-0.10.5-0.50.5
Delay discount exponential model param1.71.82.40.4-1.51.5-1.5
Delay discount hyperbolic model param1.71.82.40.4-1.61.6-1.5
Fecal boli incidents, locomotor time 10.80.91.10.7-1.01.0-1.0
Change in fecal boli incidents, locomotor task2.42.33.81.9-1.21.21.6
Time >=10cm from walls, locomotor time 10.80.81.01.0-1.01.00.3
Bouts of movement, locomotor time 10.20.20.3-0.60.5-0.5-0.1
Total resting periods, locomotor time 10.20.20.4-0.60.5-0.5-0.3
Rest time, locomotor task time 10.00.00.10.1-0.10.1-0.2
Distance moved, locomotor task time 10.60.60.91.0-0.70.70.7
Vertical activity count, locomotor time 10.00.00.0-0.0-0.10.10.1
Time >=10cm from walls, locomotor time 22.52.63.91.6-2.02.0-0.6
Bouts of movement, locomotor time 20.10.10.10.3-0.30.30.2
Total resting periods, locomotor time 20.20.20.30.5-0.50.50.3
Rest time, locomotor task time 20.81.01.61.2-0.80.81.0
Distance moved, locomotor task time 20.40.50.7-0.80.6-0.6-0.7
Vertical activity count, locomotor time 21.51.72.8-1.71.1-1.1-1.2
Weight adjusted by age0.80.92.6-0.7-0.50.5-1.6
Seeking ratio, delayed vs. immediate footshock1.61.83.21.6-0.80.81.8
Locomotion in novel chamber1.11.41.81.4-1.31.30.1
Locomotion in novel chamber post-restriction0.50.50.80.6-0.90.9-0.4
Progressive ratio1.01.22.41.5-0.90.90.8
Food seeking constrained by brief footshock2.02.43.3-1.21.8-1.81.2
Seeking ratio, punishment vs. effort2.73.44.8-2.22.1-2.10.1
Run reversals in cocaine runway, females0.80.81.6-0.20.9-0.91.3
Run reversals in cocaine runway, males4.54.37.1-2.72.2-2.2-0.7
Latency to leave start box in cocaine runway1.51.62.6-1.61.3-1.3-0.6
Latency to leave start box in cocaine runway, F0.40.50.8-0.80.5-0.5-0.9
Latency to leave start box in cocaine runway, M2.12.02.9-1.71.6-1.60.1
Cd content in liver0.40.41.00.2-0.60.6-1.0
Co content in liver1.01.13.0-0.0-0.90.9-1.7
Cu content in liver2.53.04.11.2-2.02.0-1.6
Fe content in liver0.20.20.50.1-0.40.4-0.7
K content in liver1.61.62.21.3-1.51.50.3
Mg content in liver2.72.73.91.8-2.02.00.0
Mn content in liver0.00.00.1-0.20.2-0.20.3
Na content in liver1.11.21.81.3-1.11.10.8
Rb content in liver0.30.41.30.6-0.00.01.2
Se content in liver2.63.14.01.1-2.02.0-1.8
Sr content in liver0.20.10.30.5-0.20.20.5
Zn content in liver0.40.40.5-0.70.7-0.70.1