Hub : Genes

ENSRNOG00000067232

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000067232	0.04	0.03	8.7e-03	0.03	0.04	0.02	0.03	1.1e-02	5.4e-03	2.1e-02	1.0e-02
2	Liver	gene expression	ENSRNOG00000067232	0.02	0.02	5.1e-03	0.01	0.01	0.01	0	4.0e-02	6.9e-02	5.0e-02	8.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.2	7.1	8.1	-2.5	2.8
BMI without tail	0.5	1.1	1.8	-0.7	1.3
Body weight	0.1	0.5	0.7	0.8	-0.6
Epididymis fat weight	4.5	10.5	10.9	-3.3	3.2
Glucose	0.8	1.2	1.5	1.0	-1.2
Heart weight	0.0	0.0	0.0	-0.2	-0.1
Left kidney weight	0.7	2.0	2.3	1.3	-1.5
Right kidney weight	0.3	0.9	1.1	0.9	-1.1
Tail length	3.1	9.4	10.0	3.2	-3.0
Length with tail	4.1	14.9	15.5	3.8	-3.9
Length without tail	1.8	3.9	4.8	1.7	-2.2
Liver weight, left	3.4	5.4	6.3	2.5	-2.1
Liver weight, right	0.0	0.0	0.0	0.1	-0.1
Parametrial fat weight	0.0	0.0	0.1	0.2	0.1
Retroperitoneal fat weight	0.2	0.6	0.8	-0.6	0.9
Intraocular pressure	0.1	0.1	0.1	-0.3	0.3
Extensor digitorum longus weight	5.9	23.8	25.0	5.0	-4.7
Soleus weight	0.0	0.1	0.1	-0.3	0.2
Tibialis anterior weight	0.3	1.1	1.2	1.1	-1.0
Tibia length	0.4	1.0	1.2	1.1	-0.9
Number of licking bursts	0.1	0.1	0.2	0.5	-0.2
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.3
Times rat made contact with spout	0.3	0.4	0.4	0.5	-0.7
Mean time between licks in bursts	1.0	1.3	1.4	-1.1	1.2
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	-0.1
Std. dev. time between licks in bursts	0.9	1.0	1.0	-1.0	1.0
Water consumed over 24 hours	3.3	3.9	3.9	2.0	-2.0
Indifference point 0 sec	3.3	5.2	6.1	2.1	-2.5
Indifference point AUC	2.7	3.2	3.4	1.8	-1.7
Indifference point function ln k	0.3	0.4	0.5	0.7	-0.6
Indifference point function log k	0.3	0.4	0.5	0.7	-0.6
Delay discounting total patch changes 0 sec	3.6	5.8	6.8	2.2	-2.6
Delay discounting total patch changes 12 sec	3.8	5.0	5.6	2.1	-2.4
Delay discounting total patch changes 18 sec	1.6	2.1	2.8	1.2	-1.7
Delay discounting total patch changes 24 sec	0.2	0.3	0.3	0.5	-0.5
Delay discounting total patch changes 6 sec	2.2	3.4	3.5	1.8	-1.9
Delay discounting time to switch 0 sec	10.9	16.6	17.1	-4.1	4.0
Delay discounting water rate 0 sec	18.9	30.1	30.5	5.5	-5.5
Delay discounting water rate 12 sec	9.6	14.3	15.9	4.0	-3.6
Delay discounting water rate 18 sec	4.7	6.2	6.6	2.6	-2.4
Delay discounting water rate 24 sec	3.8	5.2	5.9	2.4	-2.1
Delay discounting water rate 6 sec	4.4	6.4	6.5	2.5	-2.5
Locomotor activity	0.1	0.1	0.1	0.2	-0.4
Locomotor testing distance	0.2	0.3	0.5	0.4	-0.7
Locomotor testing rearing	1.4	2.3	2.9	-1.7	1.3
Light reinforcement 1	0.0	0.0	0.0	-0.2	0.2
Light reinforcement 2	1.8	2.4	2.8	-1.4	1.7
Reaction time number correct	3.0	4.2	4.9	1.9	-2.2
Reaction time mean minus median	0.1	0.1	0.1	-0.2	0.3
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.2	0.3
Reaction time num false alarms	0.7	1.0	1.3	0.9	-1.1
Reaction time num false alarms AUC	1.2	1.7	2.0	1.2	-1.4
Reaction time trials correct on left	3.0	4.2	4.9	1.9	-2.2
Reaction time trials on left	3.0	4.2	4.8	1.9	-2.2
Reaction time mean	0.7	1.0	1.2	-0.9	1.1
Reaction time mean AUC	0.5	0.6	0.7	-0.7	0.8
Median of all reaction times	0.5	0.7	0.7	-0.8	0.8
Reaction time omissions	1.1	1.5	1.8	1.4	-1.1
Reaction time false alarm rate	0.1	0.1	0.1	0.3	-0.3
Reaction time premature initiation rate	0.9	1.2	1.3	1.0	-1.1
Reaction time premature initiations	2.6	3.6	4.1	1.8	-2.0
Std. dev. reaction times	0.2	0.3	0.5	-0.4	0.7
Reaction time trials completed	3.0	4.2	4.8	1.9	-2.2
Reaction time trials AUC	3.2	4.6	5.2	2.0	-2.3
Social response proportion	0.4	0.5	0.6	0.6	-0.7
Social responses	0.0	0.1	0.1	-0.3	0.1
Social time	0.9	1.2	1.2	1.1	-1.1
Conditioned locomotion	1.1	1.3	1.5	1.0	-1.2
Cocaine response after cond. corrected	0.5	0.6	0.7	-0.7	0.9
Cocaine response after cond. not corrected	1.8	2.0	2.3	-1.4	1.5
Cocaine response before conditioning	2.4	2.9	3.1	-1.8	1.6
Saline control response	0.3	0.4	0.5	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	0.8	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.7	0.7	-0.9
Condit. Reinf. active responses	0.0	0.0	0.0	0.0	-0.2
Condit. Reinf. inactive responses	0.6	0.8	0.8	-0.9	0.9
Condit. Reinf. lever presses	1.4	2.0	2.0	-1.4	1.4
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.0	-0.2
Pavlov. Cond. lever latency	2.1	2.9	3.0	1.7	-1.7
Pavlov. Cond. magazine entry latency	5.1	5.9	5.9	-2.4	2.4
Pavlov. Cond. change in total contacts	3.9	5.4	6.0	-2.4	2.2
Pavlov. Cond. index score	4.9	6.5	6.7	-2.6	2.5
Pavlov. Cond. latency score	4.8	6.1	6.4	-2.5	2.4
Pavlov. Cond. lever contacts	2.8	3.9	4.1	-1.9	2.0
Pavlov. Cond. magazine entry number	3.8	4.7	5.1	2.2	-2.1
Pavlov. Cond. intertrial magazine entries	5.2	6.7	7.6	2.4	-2.7
Pavlov. Cond. lever-magazine prob. diff.	5.5	7.1	7.6	-2.8	2.6
Pavlov. Cond. response bias	3.8	5.2	5.3	-2.3	2.3
Conditioned reinforcement - actives	2.0	1.9	2.1	1.3	-1.5
Conditioned reinforcement - inactives	0.3	0.4	0.4	0.6	-0.6
Conditioned locomotion	0.9	1.0	1.2	-1.1	0.9
Intermittent access intake day 1-15 change	1.6	1.6	1.7	-1.3	1.2
Intermittent access intake escalation	1.8	1.8	1.9	-1.4	1.3
Intermittent access intake escalation 2	0.2	0.2	0.2	-0.4	0.4
Intermitt. access day 1 inactive lever presses	2.6	2.8	3.1	1.6	-1.8
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.1	0.9	-1.0
Intermitt. access escalation Index	0.5	0.4	0.5	0.7	-0.5
Intermittent access day 1 total infusions	0.4	0.4	0.4	-0.6	0.7
Intermittent access day 15 total infusions	1.9	2.1	2.1	-1.5	1.5
Intermittent access terminal intake (last 3 days)	2.2	2.4	2.4	-1.6	1.5
Intermittent access total infusions	0.7	0.8	0.9	-0.9	0.9
Intermittent access day 1 locomotion	1.0	1.0	1.0	-1.0	1.0
Intermittent access day 15 total locomotion	0.4	0.5	0.5	-0.6	0.7
Intermittent access total locomotion	0.5	0.6	0.6	-0.8	0.7
Intermittent access standard deviation	3.8	4.0	4.2	-2.0	2.0
Cocaine induced anxiety	3.1	3.6	3.7	1.9	-1.9
Post-drug Anxiety	2.6	2.9	3.0	1.7	-1.7
Baseline Anxiety	1.6	1.7	1.7	-1.3	1.3
Lifetime Intake	0.4	0.4	0.5	-0.7	0.6
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	-0.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	0.3
Progressive ratio test 1 inactive lever presses	2.7	2.8	3.1	1.6	-1.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.0
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.2	0.9	-1.1
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	0.2
Short access day 10 total inactive lever presses	0.4	0.4	0.5	0.7	-0.6
Short access day 1 total infusions	0.2	0.2	0.3	0.4	-0.5
Short access day 10 total infusions	0.4	0.5	0.6	-0.8	0.6
Short access total infusions	0.2	0.3	0.3	-0.6	0.4
Short access day 1 locomotion	0.8	0.8	1.0	-1.0	0.7
Short access day 10 total locomotion	0.7	0.7	0.8	-0.9	0.8
Short access total locomotion	0.1	0.1	0.1	-0.4	0.2
Compulsive drug intake	0.0	0.0	0.0	-0.1	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.2	-0.3
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	0.1
Number of responses in last shaping day	0.4	0.4	0.7	-0.4	0.8
Context. condit. distance diff. score	1.7	2.1	2.3	1.4	-1.5
Locomotion velocity, session 1	0.3	0.3	0.4	0.6	-0.4
Locomotion distance, session 1	0.3	0.4	0.6	-0.5	0.8
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	-0.2
Locomotion distance, session 2	0.3	0.4	0.5	-0.6	0.7
Locomotion velocity, session 3	0.2	0.3	0.4	-0.6	0.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	-0.0
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.4	-0.3
Stereotopy head waving duration, day 3	0.2	0.2	0.2	0.5	-0.4
Locomotion velocity, session 7	0.4	0.5	0.8	-0.9	0.3
Locomotion distance, session 7	0.9	1.2	1.5	-1.2	0.9
Stereotopy head waving bouts, day 7	0.8	0.9	1.1	0.9	-1.1
Stereotopy head waving duration, day 7	0.3	0.4	0.4	0.5	-0.7
Locomotion velocity, session 8	0.2	0.2	0.3	0.4	-0.5
Locomotion distance, session 8	0.0	0.0	0.0	-0.2	0.2
Degree of sensitization distance	0.1	0.1	0.2	-0.4	0.2
Degree of sensitization stereotypy	0.2	0.2	0.2	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	-0.8	0.9
Condit. Reinf. active-inactive response ratio	2.7	2.9	3.1	-1.6	1.8
Condit. Reinf. active responses	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. inactive responses	2.0	2.4	2.6	1.5	-1.6
Incentive salience index mean	0.5	0.6	0.7	-0.7	0.9
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	0.3
Time in familiar zone, hab. session 1	0.6	0.6	1.0	-1.0	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.1	0.4
Total zone transitions, hab. session 1	0.7	1.0	1.2	-0.9	1.1
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.0	-0.0
Locomotion velocity, hab. session 1	0.3	0.4	0.4	0.6	-0.6
Time in familiar zone, hab. session 2	0.7	0.7	1.1	-1.0	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	0.3
Total zone transitions, hab. session 2	0.7	0.9	1.2	-0.8	1.1
Total locomotion distance, hab. session 2	0.3	0.5	0.6	0.8	-0.5
Locomotion velocity, hab. session 2	0.5	0.7	0.8	0.9	-0.7
Novel to familiar place preference ratio	0.3	0.3	0.4	-0.5	0.6
Novelty place preference	0.2	0.2	0.2	-0.3	0.5
Time in novel zone, NPP test	0.1	0.1	0.2	-0.3	0.4
Total zone transitions, NPP test	0.1	0.2	0.4	-0.2	0.6
Total locomotion distance, NPP test	0.0	0.0	0.1	0.2	0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.3	-0.0
Pavlov. Cond. lever latency	0.8	1.0	1.1	0.9	-1.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	-1.0	0.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.6	0.5
Pavlov. Cond. index score	1.0	1.3	1.4	-1.1	1.2
Pavlov. Cond. latency score	0.7	0.9	1.0	-0.9	1.0
Pavlov. Cond. lever contacts	0.9	1.1	1.2	-1.0	1.1
Pavlov. Cond. magazine entry number	1.3	1.6	1.6	1.3	-1.2
Pavlov. Cond. intertrial magazine entries	5.3	6.4	6.5	2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.1	-0.9	1.0
Pavlov. Cond. response bias	1.5	1.8	1.9	-1.4	1.3
Bone: apparent density	0.1	0.1	0.1	-0.4	0.2
Bone surface	0.0	0.0	0.1	-0.1	0.2
Bone volume	0.0	0.1	0.1	-0.3	0.2
Bone: connectivity density	0.0	0.1	0.1	0.2	-0.3
Bone: cortical apparent density	8.9	11.5	12.0	3.3	-3.5
Bone: cortical area	0.9	1.3	1.5	1.2	-1.1
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.0
Bone: cortical porosity	0.4	0.4	0.5	-0.7	0.6
Bone: cortical thickness	0.8	1.3	1.3	1.1	-1.1
Bone: cortical thickness	0.5	0.6	0.7	0.8	-0.7
Bone: cortical tissue density	9.1	11.8	12.2	3.4	-3.5
Bone: elastic displacement	0.5	0.6	0.7	0.7	-0.8
Bone: elastic work	0.1	0.1	0.1	0.4	-0.4
Bone: endosteal estimation	0.2	0.4	0.5	-0.4	0.7
Bone: endosteal perimeter	0.0	0.0	0.0	0.2	0.2
Bone: final force	0.2	0.4	0.4	0.6	-0.6
Bone: final moment	0.3	0.5	0.5	0.7	-0.6
Bone: marrow area	0.1	0.3	0.5	-0.3	0.7
Bone: maximum diameter	0.1	0.1	0.3	0.5	-0.0
Bone: maximum force	0.3	0.5	0.5	0.7	-0.7
Bone: maximum moment	0.2	0.4	0.4	0.6	-0.6
Bone: minimum diameter	0.7	1.2	1.3	1.1	-1.1
Bone: periosteal estimation	0.1	0.2	0.4	0.6	-0.2
Bone: periosteal perimeter	0.1	0.1	0.2	0.5	-0.1
Bone: post-yield work	1.1	1.4	1.5	1.2	-1.2
Bone: stiffness	1.5	2.3	2.5	1.6	-1.4
Bone: tissue strength	0.1	0.1	0.1	0.3	-0.2
Bone: trabecular number	0.0	0.0	0.1	0.1	-0.3
Bone: trabecular spacing	0.1	0.1	0.2	-0.1	0.5
Bone: trabecular thickness	0.1	0.1	0.2	0.4	-0.4
Bone: trabecular tissue density	0.3	0.4	0.5	0.4	-0.7
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	0.1
Distance traveled before self-admin	0.0	0.0	0.0	-0.1	0.2
Distance traveled after self-admin	0.4	0.5	0.5	0.7	-0.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.3
Delta time in open arm before/after self-admin	0.6	0.6	0.6	0.8	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	0.0
Active lever presses in extinction session 6	1.3	1.2	1.2	1.1	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	-0.2
Delta ambulatory time before/after self-admin	0.4	0.5	0.6	0.6	-0.8
Time in closed arm before self-admin	3.0	3.4	3.6	-1.8	1.9
Time in closed arm after self-admin	1.7	1.8	1.9	-1.3	1.4
Time in open arm before self-admin	5.3	5.6	5.7	2.4	-2.4
Time in open arm after self-admin	3.5	3.8	3.8	2.0	-1.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.3
Time to tail flick, vehicle, before self-admin	0.6	0.7	0.8	0.9	-0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	-0.6	0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.2	-0.3
Time to tail flick, test, after self-admin	1.8	1.8	1.8	1.3	-1.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.5	0.2
Delta time to tail flick, test, before/after SA	1.0	0.9	0.9	1.0	-0.9
Ambulatory time before self-admin	0.0	0.1	0.1	-0.2	0.3
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	0.1
Total heroin consumption	1.0	1.2	1.4	1.2	-1.1
Area under the delay curve	0.0	0.0	0.1	-0.1	0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.3	-0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.0	0.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.1	0.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.0	0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.4	0.4
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.2
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	-0.2
Fecal boli incidents, locomotor time 1	1.7	1.8	2.6	-1.0	1.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.3	-0.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.5	-0.7	0.7
Bouts of movement, locomotor time 1	1.1	1.3	1.5	-1.0	1.2
Total resting periods, locomotor time 1	1.2	1.3	1.5	-1.0	1.2
Rest time, locomotor task time 1	0.3	0.3	0.5	0.7	-0.5
Distance moved, locomotor task time 1	0.4	0.5	0.8	-0.9	0.4
Vertical activity count, locomotor time 1	0.5	0.5	0.8	0.6	-0.9
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.6	0.6	-0.8
Bouts of movement, locomotor time 2	2.1	2.3	2.7	1.7	-1.3
Total resting periods, locomotor time 2	1.7	1.8	2.2	1.5	-1.2
Rest time, locomotor task time 2	0.4	0.5	0.6	0.8	-0.6
Distance moved, locomotor task time 2	0.4	0.4	0.7	-0.8	0.3
Vertical activity count, locomotor time 2	0.4	0.4	0.6	0.5	-0.8
Weight adjusted by age	0.0	0.0	0.0	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.4	0.7	-0.4
Locomotion in novel chamber	5.5	6.8	7.2	2.7	-2.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.0	0.5
Progressive ratio	0.4	0.5	0.6	0.8	-0.6
Food seeking constrained by brief footshock	1.6	1.9	2.1	1.4	-1.3
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	-0.3
Run reversals in cocaine runway, females	1.0	1.0	1.2	-1.1	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.0	0.9	-1.0
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.5	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.4	0.3
Cd content in liver	0.5	0.5	0.8	0.9	-0.5
Co content in liver	0.8	1.0	1.0	1.0	-1.0
Cu content in liver	0.9	1.1	1.3	-1.0	1.1
Fe content in liver	0.1	0.1	0.1	-0.3	0.3
K content in liver	0.1	0.1	0.1	0.3	-0.4
Mg content in liver	0.1	0.1	0.1	0.3	-0.4
Mn content in liver	0.0	0.0	0.0	-0.2	-0.1
Na content in liver	0.0	0.0	0.0	-0.1	0.1
Rb content in liver	0.7	0.9	1.1	0.9	-1.0
Se content in liver	0.1	0.1	0.2	0.1	0.5
Sr content in liver	0.4	0.3	0.5	0.7	-0.4
Zn content in liver	0.2	0.3	0.4	0.6	-0.4