Hub : Genes

ENSRNOG00000067131

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000067131	0.07	0.05	8.8e-07	0.04	0.02	0.02	0.03	1.5e-05	4.5e-03	2.0e-03	2.9e-04
2	PL	intron excision ratio	chr9:54876271:54928715	0.03	0.03	3.9e-03	0.03	0.03	0.03	0.03	1.2e-03	2.8e-03	4.0e-03	2.2e-03
3	PL	intron excision ratio	chr9:54911589:54928715	0.03	0.03	5.1e-03	0.03	0.03	0.02	0.02	5.2e-03	5.3e-03	6.5e-03	8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	4.6	14.9	16.0	-3.9	-4.0	3.7
BMI without tail	0.4	0.9	1.5	-1.0	-1.2	0.4
Body weight	1.0	4.1	4.9	1.9	1.9	-2.2
Epididymis fat weight	1.8	4.2	5.3	1.7	2.1	-2.3
Glucose	0.3	0.4	0.5	0.6	0.6	-0.7
Heart weight	0.0	0.1	0.1	-0.2	0.4	-0.0
Left kidney weight	0.1	0.4	0.6	0.6	0.7	-0.5
Right kidney weight	0.2	0.6	0.9	0.6	0.9	-0.7
Tail length	12.4	37.4	39.9	6.0	6.0	-6.3
Length with tail	11.5	42.2	43.8	6.4	6.5	-6.6
Length without tail	1.1	2.4	3.1	1.5	1.8	-1.4
Liver weight, left	0.0	0.1	0.2	-0.1	0.5	0.0
Liver weight, right	0.2	0.3	0.5	0.2	0.7	-0.6
Parametrial fat weight	0.0	0.1	0.1	-0.3	-0.1	0.4
Retroperitoneal fat weight	0.1	0.4	0.8	0.0	0.9	-0.7
Intraocular pressure	1.2	1.6	1.8	-1.3	-1.1	1.3
Extensor digitorum longus weight	1.6	6.6	7.6	-2.5	-2.7	2.5
Soleus weight	0.0	0.0	0.1	0.2	-0.3	-0.1
Tibialis anterior weight	0.7	2.4	3.0	-1.5	-1.7	1.4
Tibia length	5.7	16.1	17.1	3.8	4.1	-4.1
Number of licking bursts	0.2	0.3	0.4	-0.5	-0.6	0.5
Food consumed during 24 hour testing period	0.2	0.2	0.4	0.4	0.2	-0.6
Times rat made contact with spout	0.5	0.6	0.9	0.9	0.5	-0.9
Mean time between licks in bursts	0.1	0.1	0.2	-0.2	-0.3	0.4
Mean num. licks in bursts	0.4	0.5	0.7	0.8	0.6	-0.7
Std. dev. time between licks in bursts	1.3	1.5	1.6	-1.2	-1.3	1.3
Water consumed over 24 hours	0.4	0.5	1.2	-0.5	-1.1	0.3
Indifference point 0 sec	1.5	2.4	3.1	-1.5	-1.8	1.4
Indifference point AUC	0.0	0.0	0.1	0.0	-0.3	0.0
Indifference point function ln k	1.7	2.4	2.6	-1.6	-1.5	1.6
Indifference point function log k	1.7	2.4	2.6	-1.6	-1.5	1.6
Delay discounting total patch changes 0 sec	1.3	2.1	2.8	-1.4	-1.7	1.3
Delay discounting total patch changes 12 sec	0.0	0.1	0.2	-0.0	-0.4	-0.0
Delay discounting total patch changes 18 sec	2.7	3.5	4.3	-1.7	-2.1	1.9
Delay discounting total patch changes 24 sec	0.1	0.2	0.5	-0.2	-0.7	0.1
Delay discounting total patch changes 6 sec	1.7	2.6	3.8	-1.6	-1.9	1.2
Delay discounting time to switch 0 sec	0.6	0.8	1.2	0.8	0.9	-1.1
Delay discounting water rate 0 sec	0.1	0.2	0.3	-0.3	-0.4	0.5
Delay discounting water rate 12 sec	1.3	2.0	2.2	-1.5	-1.3	1.5
Delay discounting water rate 18 sec	0.0	0.0	0.0	-0.2	0.1	-0.1
Delay discounting water rate 24 sec	0.1	0.1	0.2	0.3	0.4	-0.1
Delay discounting water rate 6 sec	0.4	0.6	0.6	-0.8	-0.8	0.8
Locomotor activity	0.2	0.3	0.5	-0.4	-0.7	0.4
Locomotor testing distance	0.8	1.3	2.1	-1.0	-1.4	0.9
Locomotor testing rearing	0.1	0.2	0.4	-0.2	-0.7	-0.0
Light reinforcement 1	0.1	0.1	0.2	-0.4	-0.5	0.1
Light reinforcement 2	1.4	1.8	2.1	1.4	1.4	-1.2
Reaction time number correct	0.5	0.7	0.9	-0.8	-0.7	0.9
Reaction time mean minus median	5.5	7.2	8.2	2.9	2.6	-2.6
Reaction time mean minus median AUC	4.0	5.1	5.7	2.4	2.3	-2.0
Reaction time num false alarms	1.4	1.9	2.8	-1.3	-1.7	1.0
Reaction time num false alarms AUC	1.1	1.6	2.5	-1.2	-1.6	0.9
Reaction time trials correct on left	0.5	0.7	0.9	-0.8	-0.7	0.9
Reaction time trials on left	0.3	0.5	0.7	-0.7	-0.5	0.8
Reaction time mean	9.4	12.9	14.2	3.6	3.8	-3.4
Reaction time mean AUC	9.6	12.7	13.8	3.6	3.7	-3.4
Median of all reaction times	7.9	10.7	12.4	3.2	3.5	-3.1
Reaction time omissions	2.6	3.5	4.0	1.8	1.8	-2.0
Reaction time false alarm rate	0.5	0.7	1.3	-0.7	-1.1	0.4
Reaction time premature initiation rate	3.8	5.1	5.9	-2.4	-2.0	2.4
Reaction time premature initiations	4.5	6.4	7.7	-2.7	-2.1	2.8
Std. dev. reaction times	7.1	9.7	10.2	3.2	3.1	-3.0
Reaction time trials completed	0.3	0.5	0.7	-0.7	-0.5	0.8
Reaction time trials AUC	0.3	0.5	0.7	-0.7	-0.5	0.8
Social response proportion	2.3	2.5	3.0	1.4	1.7	-1.5
Social responses	0.5	0.7	1.0	0.6	1.0	-0.8
Social time	0.5	0.6	1.4	0.6	1.2	-0.5
Conditioned locomotion	3.8	4.5	4.9	2.0	2.2	-2.1
Cocaine response after cond. corrected	0.5	0.6	0.8	0.8	0.9	-0.6
Cocaine response after cond. not corrected	0.4	0.5	0.6	0.8	0.7	-0.6
Cocaine response before conditioning	0.3	0.4	0.6	-0.5	-0.8	0.6
Saline control response	0.1	0.1	0.2	0.5	-0.1	-0.3
Condit. Reinf. active minus inactive responses	2.3	2.9	3.5	1.6	1.9	-1.6
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.1	0.6	1.0	-0.6
Condit. Reinf. active responses	0.5	0.7	0.8	0.8	0.9	-0.9
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.6	-0.7	0.6
Condit. Reinf. lever presses	0.8	1.2	1.5	-0.9	-1.2	1.1
Condit. Reinf. lever reinforcers received	0.4	0.5	0.7	0.6	0.8	-0.7
Pavlov. Cond. lever latency	1.4	1.9	2.2	1.2	1.5	-1.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.5	-0.7	0.7
Pavlov. Cond. change in total contacts	0.6	0.8	1.1	-1.1	-0.4	1.1
Pavlov. Cond. index score	0.6	0.8	1.0	-0.8	-0.8	1.0
Pavlov. Cond. latency score	0.4	0.4	0.6	-0.6	-0.6	0.8
Pavlov. Cond. lever contacts	1.0	1.3	1.6	-1.0	-1.2	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	-0.4	-0.8	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.2	-0.9	-0.9	1.1
Pavlov. Cond. response bias	0.3	0.5	0.6	-0.5	-0.7	0.8
Conditioned reinforcement - actives	0.6	0.6	0.8	0.9	0.7	-0.7
Conditioned reinforcement - inactives	0.6	0.7	0.8	0.9	0.9	-0.6
Conditioned locomotion	0.0	0.0	0.1	-0.0	-0.2	0.0
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.4	-0.2	0.1
Intermittent access intake escalation	0.3	0.3	0.5	-0.7	-0.4	0.4
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.0	0.2	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	0.0	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.1	-0.2	0.3
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	0.2	-0.4
Intermittent access day 1 total infusions	4.8	5.5	6.3	2.4	2.1	-2.5
Intermittent access day 15 total infusions	2.5	2.8	3.7	1.6	1.6	-1.9
Intermittent access terminal intake (last 3 days)	1.4	1.5	1.8	1.2	1.1	-1.4
Intermittent access total infusions	4.4	4.9	5.5	2.2	2.1	-2.4
Intermittent access day 1 locomotion	0.6	0.6	0.9	0.7	0.6	-0.9
Intermittent access day 15 total locomotion	0.7	0.7	1.2	0.8	0.7	-1.1
Intermittent access total locomotion	0.9	1.0	1.5	0.9	0.9	-1.2
Intermittent access standard deviation	0.2	0.2	0.2	0.4	0.4	-0.4
Cocaine induced anxiety	0.8	0.9	1.3	-0.9	-1.1	0.8
Post-drug Anxiety	1.0	1.1	1.4	-0.9	-1.2	1.0
Baseline Anxiety	0.2	0.2	0.4	0.5	0.6	-0.4
Lifetime Intake	3.4	3.8	4.2	2.0	1.9	-2.0
Incentive Sensitization - Responses	1.4	1.4	1.4	1.2	1.1	-1.1
Incentive Sensitization - Breakpoint	1.2	1.2	1.3	1.1	1.1	-1.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.2	0.6	0.7	-1.1
Progressive ratio test 1 breakpoint	0.6	0.6	1.2	0.6	0.6	-1.1
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	0.6	0.6	-0.9
Progressive ratio test 2 active lever presses	1.9	2.0	2.2	1.3	1.5	-1.5
Progressive ratio test 2 breakpoint	1.1	1.2	1.3	1.0	1.1	-1.1
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.2	1.1	0.9	-0.9
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	-0.0	-0.2
Short access day 1 total inactive lever presses	0.4	0.4	0.5	0.7	0.6	-0.7
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	0.1	0.1
Short access day 1 total infusions	0.3	0.3	0.4	0.5	0.6	-0.7
Short access day 10 total infusions	5.5	6.1	6.3	2.5	2.4	-2.5
Short access total infusions	1.1	1.3	1.4	1.1	1.1	-1.2
Short access day 1 locomotion	0.6	0.7	0.9	0.6	0.8	-1.0
Short access day 10 total locomotion	0.0	0.0	0.0	-0.2	-0.1	0.1
Short access total locomotion	0.6	0.6	1.0	0.6	0.6	-1.0
Compulsive drug intake	0.9	0.9	1.1	-0.8	-1.0	1.0
One hour access (0.3 mA shock)	2.5	2.9	3.4	1.8	1.7	-1.6
One hour access (shock baseline)	5.3	6.1	6.7	2.6	2.4	-2.4
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	-0.2	0.4
Context. condit. distance diff. score	1.4	1.7	1.9	-1.2	-1.4	1.3
Locomotion velocity, session 1	2.8	3.0	4.1	-1.7	-1.4	2.0
Locomotion distance, session 1	0.3	0.4	0.6	-0.6	-0.8	0.6
Locomotion velocity, session 2	2.7	3.1	3.6	-1.7	-1.7	1.9
Locomotion distance, session 2	0.0	0.0	0.0	0.2	0.1	0.2
Locomotion velocity, session 3	0.3	0.4	0.4	0.6	0.6	-0.7
Locomotion distance, session 3	0.1	0.1	0.1	-0.1	0.4	0.1
Stereotopy head waving bouts, day 3	0.4	0.4	0.6	-0.7	-0.4	0.8
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.2	-0.0	0.1
Locomotion velocity, session 7	4.0	4.4	4.8	-2.1	-2.0	2.2
Locomotion distance, session 7	0.2	0.2	0.4	-0.3	-0.6	0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.5	0.3	0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.8	-0.0	0.5
Locomotion velocity, session 8	4.0	4.8	5.0	-2.2	-2.1	2.2
Locomotion distance, session 8	0.8	1.2	1.4	-1.0	-1.1	1.2
Degree of sensitization distance	0.1	0.1	0.4	0.1	-0.6	0.1
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.7	0.1	0.3
Condit. Reinf. active minus inactive responses	0.9	1.0	1.3	1.0	1.1	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	0.6	0.7	-0.5
Condit. Reinf. active responses	1.0	1.3	1.3	1.2	1.2	-1.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	0.2	-0.3
Incentive salience index mean	0.6	0.7	0.8	0.8	0.9	-0.8
Condit. Reinf. lever presses	0.3	0.4	0.4	0.6	0.5	-0.6
Time in familiar zone, hab. session 1	0.5	0.5	0.6	-0.8	-0.8	0.5
Time in novel zone, hab. session 1	0.8	0.8	1.7	0.8	1.3	-0.3
Total zone transitions, hab. session 1	0.6	0.8	1.2	-0.9	-0.6	1.1
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.7	0.8	-0.3
Locomotion velocity, hab. session 1	0.9	1.2	1.6	1.3	1.2	-0.8
Time in familiar zone, hab. session 2	0.3	0.3	0.5	-0.3	-0.7	0.6
Time in novel zone, hab. session 2	0.7	0.7	1.1	0.6	1.1	-0.7
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.3	0.2	-0.1
Total locomotion distance, hab. session 2	2.5	3.3	4.3	2.1	1.7	-1.6
Locomotion velocity, hab. session 2	2.3	3.1	4.1	2.0	1.6	-1.6
Novel to familiar place preference ratio	8.7	9.1	10.6	2.9	3.3	-2.9
Novelty place preference	8.3	8.6	10.1	2.8	3.2	-2.7
Time in novel zone, NPP test	7.9	8.3	10.6	2.8	3.3	-2.6
Total zone transitions, NPP test	0.2	0.2	0.4	-0.4	-0.3	0.7
Total locomotion distance, NPP test	0.4	0.6	1.0	0.8	1.0	-0.4
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	0.7	-0.5
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.3	-0.2	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.4	0.3	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	-0.2	-0.1
Pavlov. Cond. index score	0.3	0.3	0.4	0.6	0.5	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.4	0.5	0.5	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.5	0.5	0.4	-0.7
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	-0.8	-0.9	0.8
Pavlov. Cond. intertrial magazine entries	1.4	1.6	2.2	1.5	1.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	0.2	-0.4
Pavlov. Cond. response bias	0.5	0.6	0.7	0.8	0.8	-0.8
Bone: apparent density	3.6	5.9	8.1	2.5	1.9	-2.8
Bone surface	3.6	6.4	7.8	2.6	2.1	-2.8
Bone volume	3.8	6.5	8.9	2.5	2.1	-3.0
Bone: connectivity density	1.2	1.9	2.7	1.5	0.9	-1.6
Bone: cortical apparent density	5.1	6.7	8.4	-2.4	-2.9	2.4
Bone: cortical area	0.2	0.3	0.4	0.3	0.6	-0.6
Bone: cortical porosity	4.5	4.9	5.1	2.2	2.3	-2.1
Bone: cortical porosity	5.8	6.3	6.4	2.5	2.5	-2.5
Bone: cortical thickness	1.0	1.7	2.4	-1.6	-1.1	1.2
Bone: cortical thickness	2.1	2.5	3.1	-1.8	-1.2	1.7
Bone: cortical tissue density	5.2	6.8	8.5	-2.4	-2.9	2.4
Bone: elastic displacement	0.2	0.2	0.3	-0.5	-0.4	0.5
Bone: elastic work	1.2	1.5	2.0	1.2	1.0	-1.4
Bone: endosteal estimation	5.3	11.4	11.9	3.4	3.2	-3.4
Bone: endosteal perimeter	3.7	7.6	8.1	2.8	2.6	-2.8
Bone: final force	3.9	6.3	7.2	2.4	2.4	-2.7
Bone: final moment	3.1	5.1	6.1	2.2	2.2	-2.5
Bone: marrow area	5.0	10.8	11.3	3.4	3.2	-3.3
Bone: maximum diameter	0.4	0.8	0.9	0.9	1.0	-0.8
Bone: maximum force	5.1	8.8	10.2	2.9	2.8	-3.2
Bone: maximum moment	4.3	7.5	8.9	2.6	2.6	-3.0
Bone: minimum diameter	1.2	2.3	2.3	1.5	1.5	-1.5
Bone: periosteal estimation	3.4	7.0	7.4	2.6	2.6	-2.7
Bone: periosteal perimeter	2.6	4.3	4.5	2.0	2.1	-2.1
Bone: post-yield work	2.4	3.3	4.0	1.7	1.8	-2.0
Bone: stiffness	5.0	7.8	8.6	2.8	2.7	-2.9
Bone: tissue strength	1.9	1.9	2.4	1.3	1.3	-1.5
Bone: trabecular number	1.9	2.9	4.8	1.6	1.2	-2.2
Bone: trabecular spacing	1.1	1.4	2.4	-1.2	-0.8	1.6
Bone: trabecular thickness	1.2	1.4	2.3	1.1	0.8	-1.5
Bone: trabecular tissue density	0.2	0.2	0.4	0.7	0.3	-0.5
Breakpoint value in progressive ratio session	1.2	1.4	1.6	1.1	1.3	-1.1
Distance traveled before self-admin	2.7	2.9	3.6	1.6	1.9	-1.6
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	0.0	0.2
Delta time in closed arm before/after self-admin	0.5	0.5	0.6	-0.7	-0.6	0.8
Delta time in open arm before/after self-admin	3.9	3.7	3.9	2.0	1.8	-2.0
Diff in mean of infusions in LGA sessions	0.3	0.4	0.4	0.6	0.6	-0.7
Extinction: sum of active levers before priming	2.9	2.9	3.5	1.7	1.9	-1.5
Active lever presses in extinction session 6	2.1	2.0	2.4	1.3	1.3	-1.5
Delta distance traveled before/after self-admin	0.7	0.8	0.9	-0.9	-0.9	0.8
Delta ambulatory time before/after self-admin	0.3	0.4	0.5	-0.5	-0.7	0.5
Time in closed arm before self-admin	2.0	2.3	2.6	1.6	1.5	-1.5
Time in closed arm after self-admin	0.2	0.2	0.3	-0.4	-0.4	0.5
Time in open arm before self-admin	1.4	1.5	1.9	-1.4	-1.1	1.2
Time in open arm after self-admin	1.9	2.1	2.1	1.4	1.4	-1.4
Sum of active levers in priming session hrs 5-6	3.3	3.2	3.5	1.6	1.9	-1.9
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.7	-0.8	-0.6	0.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.3	0.6	0.5	-0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.2	-0.3	0.3
Time to tail flick, test, after self-admin	1.0	1.1	1.3	-1.1	-1.0	1.0
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.2	1.1	0.9	-0.8
Delta time to tail flick, test, before/after SA	0.5	0.4	0.6	-0.8	-0.6	0.6
Ambulatory time before self-admin	1.4	1.5	2.1	1.1	1.4	-1.1
Ambulatory time after self-admin	0.2	0.2	0.2	-0.5	-0.4	0.4
Total heroin consumption	1.1	1.4	1.7	1.2	1.3	-1.0
Area under the delay curve	0.6	0.6	0.7	-0.7	-0.9	0.7
Delay disc. indifference point, 0s delay	1.0	1.1	1.1	-1.1	-1.1	1.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	-0.4	-0.7	0.5
Delay disc. indifference point, 2s delay	0.6	0.7	0.7	-0.9	-0.7	0.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.5	-0.5	0.4
Delay disc. indifference point, 4s delay	2.3	2.4	2.7	-1.5	-1.6	1.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.0	-0.2	0.1
Delay discount exponential model param	0.4	0.4	0.5	0.6	0.7	-0.6
Delay discount hyperbolic model param	0.7	0.8	0.9	0.8	1.0	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.3	-0.5	-0.6	0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.2	0.3	-0.1
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.3	-1.0	-0.9	1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.3	-0.4	0.2
Total resting periods, locomotor time 1	0.6	0.7	1.0	-0.8	-1.0	0.6
Rest time, locomotor task time 1	0.4	0.5	0.5	0.7	0.7	-0.7
Distance moved, locomotor task time 1	0.4	0.4	0.5	-0.7	-0.6	0.6
Vertical activity count, locomotor time 1	0.8	0.9	1.0	-0.9	-0.9	1.0
Time >=10cm from walls, locomotor time 2	0.6	0.6	0.8	0.8	0.9	-0.6
Bouts of movement, locomotor time 2	1.9	2.0	2.4	-1.5	-1.5	1.2
Total resting periods, locomotor time 2	1.9	2.1	2.3	-1.5	-1.5	1.3
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	0.2	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.3	-0.3	0.3
Vertical activity count, locomotor time 2	0.3	0.3	0.4	-0.6	-0.6	0.5
Weight adjusted by age	0.0	0.0	0.1	-0.2	-0.1	-0.0
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	1.9	1.4	1.3	-1.3
Locomotion in novel chamber	1.2	1.5	1.6	-1.3	-1.3	1.1
Locomotion in novel chamber post-restriction	0.9	1.0	1.1	-1.0	-1.0	1.0
Progressive ratio	0.1	0.1	0.2	-0.3	-0.4	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.1	-0.2	0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.3	0.2	-0.2
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.0	-0.1	-0.1
Run reversals in cocaine runway, males	0.4	0.4	0.5	-0.7	-0.7	0.6
Latency to leave start box in cocaine runway	3.9	4.3	5.0	-2.0	-2.0	2.2
Latency to leave start box in cocaine runway, F	2.6	2.9	3.6	-1.6	-1.5	1.9
Latency to leave start box in cocaine runway, M	1.4	1.3	1.4	-1.1	-1.2	1.2
Cd content in liver	0.5	0.6	0.8	0.8	0.6	-0.9
Co content in liver	0.1	0.2	0.2	-0.4	-0.3	0.5
Cu content in liver	0.2	0.2	0.3	0.5	0.4	-0.6
Fe content in liver	2.7	3.2	3.9	2.0	1.4	-1.9
K content in liver	0.1	0.1	0.1	-0.3	-0.2	0.0
Mg content in liver	0.1	0.1	0.2	0.1	0.3	-0.5
Mn content in liver	2.3	2.6	3.2	-1.7	-1.8	1.3
Na content in liver	0.2	0.2	0.3	-0.5	-0.5	0.3
Rb content in liver	0.5	0.6	0.8	-0.9	-0.9	0.5
Se content in liver	0.2	0.2	0.3	0.5	0.1	-0.6
Sr content in liver	2.1	1.9	2.2	1.3	1.3	-1.5
Zn content in liver	0.1	0.1	0.2	0.3	0.0	-0.5